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Cucurmin

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https://www.readbyqxmd.com/read/27874279/cucurmin-anticancer-and-antitumor-perspectives-a-comprehensive-review
#1
Muhammad Imran, Farhan Saeed, Muhammad Nadeem, Muhammad Umair Arshad, Azmat Ullah, Hafiz Ansar Rasul Suleria
Cucurmin, a naturally yellow component isolated from turmeric, ability to prevent various life-style related disorders. The current review article mainly emphasizes on different anticancer perspectives of cucurmin i.e. colon, cervical, uterine, ovarian, prostate head and neck, breast, pulmonary, stomach and gastric, pancreatic, bladder oral, oesophageal and bone cancer. It holds a mixture of strong bioactive molecule known as cucurminoids that has ability to reduce cancer/tumor at initial, promotion and progression stages of tumor development...
November 22, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27866299/localization-and-dynamics-of-the-anticarcinogenic-curcumin-with-gm1-and-other-miceller-assemblies
#2
Malay Patra, Manoj Mandal, Abhijit Chakrabarti, Chaitali Mukhopadhyay
Structural transitions involving shape changes play an important role in cellular physiology and enhance the bioavailability of the natural food like curcumin in surfactant aggregates. In this work, we have studied the localization, dynamics and stability of curcumin in various miceller assemblies using a combination of absorbance and fluorescence spectroscopic approaches. The measurements of absorption and fluorescence spectra of curcumin revealed that the nature of interactions of ionic and nonionic surfactants and the glycosphingolipid, GM1 with curcumin is significantly different with surfactant concentrations...
November 19, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27072713/antioxidant-therapy-against-trypanosome-infections-a-review-update
#3
REVIEW
Mohammed Auwal Ibrahim, Murtala Bindawa Isah, Abdulmalik Abdullahi Salman
Trypanosomiasis is a serious parasitic disease that affects humans and animals resulting in heavy health and economic burdens. Disturbance of redox equilibrium represents a classical challenge for both the host and the parasite during infections with either extracellular African or intracellular American trypanosomes species. This is in spite of existing detoxification mechanisms in both the host and the parasite for maintaining oxidative balance. However, oxidative stress still plays vital roles in the induction of numerous host-associated pathological damages such as anemia, hepatic and renal damages as well as cardiomyopathy while on the other hand, drugs that specifically induce oxidative stress to the parasite have been effective...
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/26456563/curcumin-induces-brown-fat-like-phenotype-in-3t3-l1-and-primary-white-adipocytes
#4
Jameel Lone, Jae Heon Choi, Sang Woo Kim, Jong Won Yun
Recent advances have been made in the understanding of pharmacological and dietary agents that contribute to browning of white adipose tissue in order to combat obesity by promoting energy expenditure. Here, we show that curcumin induces browning of 3T3-L1 and primary white adipocytes via enhanced expression of brown fat-specific genes. Curcumin-induced browning in white adipocytes was investigated by determining expression levels of brown adipocyte-specific genes/proteins by real-time reverse transcriptase polymerase chain reaction, immunoblot analysis and immunocytochemical staining...
January 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/25082512/design-synthesis-and-evaluation-of-rivastigmine-and-curcumin-hybrids-as-site-activated-multitarget-directed-ligands-for-alzheimer-s-disease-therapy
#5
Yujie Li, Peng Peng, Li Tang, Yunzhen Hu, Yongzhou Hu, Rong Sheng
A series of novel 2-methoxy-phenyl dimethyl-carbamate derivatives were designed, synthesized and evaluated as site-activated MTDLs based on rivastigmine and curcumin. Most of them exhibited good to excellent AChE and BuChE inhibitory activities with sub-micromolar IC50 values. Among all the compounds, 6a demonstrated the most potent AChE inhibition with IC50 value of 0.097μM, which is about 20-fold than that of rivastigmine. In addition, the three selected compounds 5a, 6a and 6e demonstrated inhibitory activity against Aβ self-aggregation similar to cucurmin in TEM assay, which is obviously different from the weak activity of rivastigmine...
September 1, 2014: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/23347386/curcumin-alleviates-immune-complex-mediated-glomerulonephritis-in-factor-h-deficient-mice
#6
Alexander Jacob, Lee Chaves, Michael T Eadon, Anthony Chang, Richard J Quigg, Jessy J Alexander
Complement factor H (Cfh) is a key regulator of the complement cascade and protects C57BL/6 mice from immune complex-mediated complement-dependent glomerulonephritis. In chronic serum sickness (CSS) there are increased deposits of immune complexes in the glomeruli with inflammation and a scarring phenotype. As cucurmin is an effective anti-inflammatory agent and reduces complement activation, we hypothesized that it should alleviate renal disease in this setting. To determine the effectiveness of curcumin, an apoferritin-induced CSS model in Cfh-deficient (Cfh(-/-)) mice was used...
July 2013: Immunology
https://www.readbyqxmd.com/read/22472046/inhibition-of-cholinesterase-activity-and-amyloid-aggregation-by-berberine-phenyl-benzoheterocyclic-and-tacrine-phenyl-benzoheterocyclic-hybrids
#7
Ling Huang, Tao Su, Wenjun Shan, Zonghua Luo, Yang Sun, Feng He, Xingshu Li
A series of berberine-phenyl-benzoheterocyclic (26-29) and tacrine-phenyl-benzoheterocyclic hybrids (44-46) were synthesised and evaluated as multifunctional anti-Alzheimer's disease agents. Compound 44b, tacrine linked with phenyl-benzothiazole by 3-carbon spacers, was the most potent AChE inhibitor with an IC(50) value of 0.017 μM. This compound demonstrated similar Aβ aggregation inhibitory activity with cucurmin (51.8% vs 52.1% at 20 μM, respectively), indicating that this hybrid is an excellent multifunctional drug candidate for AD...
May 1, 2012: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/21461234/involvement-of-ros-in-curcumin-induced-autophagic-cell-death
#8
Youn Ju Lee, Nam-Yi Kim, Young-Ah Suh, Chuhee Lee
Many anticancer agents as well as ionizing radiation have been shown to induce autophagy which is originally described as a protein recycling process and recently reported to play a crucial role in various disorders. In HCT116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and degradation of sequestome-1 (SQSTM1) which is a marker of autophagosome degradation...
February 2011: Korean Journal of Physiology & Pharmacology
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