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https://www.readbyqxmd.com/read/29786184/-protein-carbamylation-what-it-is-and-why-it-concerns-nephrologists
#1
Emanuele De Simone, Lucia Di Micco, Gaetano La Manna, Biagio Di Iorio
Spontaneous urea dissociation in water solution is a prominent source of protein carbamylation in our body. Protein carbamylation is a well-known phenomenon since early seventies. Some years ago, much interest in the diagnostic power of carbamylated protein arouse. Recently the target of the researches focused on its potential cardiovascular pathogenicity. Some authors claimed that this could be a reason for higher cardiovascular mortality in uremic patients. Nutritional therapy, amino acids supplementation and intensive dialysis regimen are some of the therapeutic tools tested to lower the carbamylation burst in this population...
May 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29781336/advances-in-the-treatment-of-severe-alcoholic-hepatitis
#2
Wenjun Wang, Ying Xu, Chang Jiang, Yanhang Gao
Severe alcoholic hepatitis (SAH) is a costly and worldwide public health issue with high morbidity and mortality. Specific effective treatments for SAH have yet to be established. The aim of the present article is to review the current knowledge of the pathogenesis, assessment, and treatment options in patients with SAH. To date, alcohol abstinence and enteral nutrition are the recommended first-line treatments. Although corticosteroids remain the preferred therapy for certain patients with a modified Maddrey discriminant function level greater than 54, they only improve short-term survival rates...
May 21, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29779821/clinical-efficacy-and-feasibility-of-whey-protein-isolates-supplementation-in-malnourished-peritoneal-dialysis-patients-a-multicenter-parallel-open-label-randomized-controlled-trial
#3
Sharmela Sahathevan, Chee-Hee Se, SeeHoe Ng, Ban-Hock Khor, Karuthan Chinna, Bak Leong Goh, Halim A Gafor, Sunita Bavanandan, Ghazali Ahmad, Tilakavati Karupaiah
BACKGROUND AND AIMS: Poor dietary intake is commonly associated with malnutrition in the dialysis population and oral nutritional supplementation is strategized to redress dietary inadequacy. Knowledge on clinical efficacy of whey protein supplementation (WPS) as an option to treat malnutrition in continuous ambulatory peritoneal dialysis (CAPD) patients is limited. METHODS: This multicenter, parallel, open-label, randomized controlled trial investigated the clinical efficacy of WPS in 126 malnourished CAPD patients with serum albumin <40 g/L and body mass index (BMI) <24 kg/m2 ...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29759796/factors-associated-with-anthropometric-indicators-of-nutritional-status-in-children-with-chronic-kidney-disease-undergoing-peritoneal-dialysis-hemodialysis-and-after-kidney-transplant
#4
Julieta García De Alba Verduzco, Erika Fabiola Hurtado López, Consuelo Pontón Vázquez, Adriana de la Torre Serrano, Enrique Romero Velarde, Edgar Manuel Vásquez Garibay
OBJECTIVE: The objective of the study was to demonstrate that there are differences in the factors associated with anthropometric indicators of nutritional status, with particular emphasis on arm indicators, in children with end-stage kidney disease undergoing peritoneal dialysis (PD), hemodialysis (HD), and after kidney transplant (KT). METHODS: An analytical cross-sectional study of consecutive cases included 130 children and adolescents with end-stage kidney disease undergoing substitutive treatment: 49 patients who underwent KT, 33 undergoing PD, and 47 undergoing HD...
May 11, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29737013/incremental-dialysis-for-preserving-residual-kidney-function-does-one-size-fit-all-when-initiating-dialysis
#5
Anna T Mathew, Yoshitsugu Obi, Connie M Rhee, Jason A Chou, Kamyar Kalantar-Zadeh
While many patients have substantial residual kidney function (RKF) when initiating hemodialysis (HD), most patients with end stage renal disease in the United States are initiated on 3-times per week conventional HD regimen, with little regard to RKF or patient preference. RKF is associated with many benefits including survival, volume control, solute clearance, and reduced inflammation. Several strategies have been recommended to preserve RKF after HD initiation, including an incremental approach to HD initiation...
May 7, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29734150/association-between-increases-in-normalized-protein-catabolic-rate-and-increases-in-creatinine-generation-rate-in-dialysis-patients
#6
Norio Hanafusa, Daigo Kamei, Misao Tsukada, Naoko Miwa, Mizuki Komatsu, Shunji Shiohira, Masayuki Okazaki, Ryota Watanabe, Hiroshi Kawaguchi, Ken Tsuchiya, Kosaku Nitta
The older dialysis population is growing, and malnutrition and wasting syndrome are great concerns in this population. The management of these syndromes includes appropriate nutritional intake and physical activity. However, whether management in the form of an increase in protein intake has a beneficial effect on muscle mass has not been demonstrated. In this study, we investigated an association between changes of normalized protein catabolic rate (nPCR), as a proxy for protein intake and percent creatinine generation rate (%CGR), as a proxy for muscle mass in patients receiving hemodialysis...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29731493/current-practice-and-outcomes-of-peritoneal-dialysis-in-the-nippon-medical-school-musashi-kosugi-hospital
#7
Yuichiro Sumi, Yukinao Sakai, Koji Mugishima, Anna Suzuki, Yusuke Otsuka, Tomoyuki Otsuka, Shuichi Tsuruoka
INTRODUCTION: Various innovations for preventing complications and improving a patient's quality of life have been implemented for peritoneal dialysis (PD), which was established in Japan approximately 35 years ago and introduced at our hospital in 1999. Herein, we investigate the outcomes of patients undergoing PD to identify approaches for improving their long-term prognosis. METHODS: This retrospective study included 114 patients who underwent PD between September 1999 and August 2017 and included various parameters such as patient survival rate, technical survival rate, cause (s) of PD withdrawal, incidence of peritonitis, dialysis duration, and change in residual renal function (RRF)...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29731235/assessment-of-nutritional-status-in-children-with-chronic-kidney-disease-using-hand-grip-strength-tool
#8
Ashraf Mohamed Abd El Basset Bakr, Bothina Mohamed Hasaneen, Dina AbdelRasoul Helal Bassiouni
OBJECTIVE: Muscle status assessment is crucial for diagnosis of protein energy wasting PEW/cachexia in chronic kidney disease (CKD) population. Hand grip strength (HGS) has been used in muscle power assessment in adult CKD. However, no data is available about its usefulness in children with CKD. Hence, we aimed to study the reliability of HGS in reflecting the muscle power and thus, nutritional status in children with CKD. DESIGN AND METHODS: In this Observational cross sectional study we enrolled 73 CKD children; 45 had end stage kidney disease (ESKD) on hemodialysis (HD) and 28 had CKD but not on dialysis yet...
May 3, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29725741/-metabolic-management-and-nutrition-in-critically-ill-patients-with-renal-dysfunction-recommendations-from-the-renal-section-of-the-dgiin-%C3%A3-giain-and-divi
#9
W Druml, M Joannidis, S John, A Jörres, M Schmitz, J Kielstein, D Kindgen-Milles, M Oppert, V Schwenger, C Willam, A Zarbock
BACKGROUND: Intensive care patients with renal failure or insufficiency comprise a heterogeneous group of subjects with widely differing metabolic patterns and nutritional requirements. They include subjects with various stages of acute kidney injury (AKI), acute-on-chronic renal failure (A-CKD), without/with renal replacement therapy (RRT), chronic kidney disease (CKD), and subjects on regular hemodialysis or peritoneal dialysis therapy (HD/PD). GOALS: Development of recommendations by the renal section of DGIIN (Deutsche Gesellschaft für Internistische Intensivmedizin und Notfallmedizin), ÖGIAIN (Österreichische Gesellschaft für Internistische und Allgemeine Intensivmedizin und Notfallmedizin) and DIVI (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin) for the metabolic management and the planning, indication, implementation, and monitoring of nutrition therapy in this heterogeneous group of patients...
May 3, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29709365/protein-losses-and-urea-nitrogen-underestimate-total-nitrogen-losses-in-peritoneal-dialysis-and-hemodialysis-patients
#10
Clara Salame, Simon Eaton, George Grimble, Andrew Davenport
OBJECTIVE: Muscle wasting is associated with increased mortality and is commonly reported in dialysis patients. Hemodialysis (HD) and peritoneal dialysis (PD) treatments lead to protein losses in effluent dialysate. We wished to determine whether changes in current dialysis practice had increased therapy-associated nitrogen losses. DESIGN: Cross-sectional cohort study. METHODS: Measurement of total protein, urea and total nitrogen in effluent dialysate from 24-hour collections from PD patients, and during haemodiafiltration (HDF) and haemodialysis (HD) sessions...
April 28, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29694445/survival-predictors-in-anuric-patients-on-peritoneal-dialysis-a-prospective-multicenter-propensity-score-matched-cohort-study
#11
Ja-Yong Park, Jang-Hee Cho, Hye Min Jang, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim
Prevalent anuric peritoneal dialysis (PD) patients usually have higher mortality than PD patients with residual urine volume. We aimed to evaluate the predictors of survival in anuric PD patients. Anuric PD patients (n = 505, <100 mL of daily urine) enrolled in Korean nationwide prospective cohort were analyzed. Survived and non-survived anuric PD patients were compared by propensity score matching analysis with a ratio of two to one. The propensity method was used to adjust for patient age, dialysis duration, and presence of diabetes...
2018: PloS One
https://www.readbyqxmd.com/read/29694310/superior-vena-cava-syndrome-due-to-central-port-catheter-thrombosis-a-real-life-threatening-condition
#12
G D Lianos, N Hasemaki, E Tzima, G Vangelis, A Tselios, I Mpailis, E Lekkas
Superior vena cava syndrome (SVCS) represents undoubtedly a rare life-threatening condition. Herein, we present a rare case of a 69-year-old woman, with a history of hepatic flexure tumor and an indwelling central venous port, presenting with acute signs and symptoms of SVCS due to thrombosis of the catheter. The patient was treated with intravenous anticoagulation and fibrinolytic therapy and showed regression of symptoms. It is reported that central venous catheters are routinely used in clinical practice mainly in oncological cases for chemotherapy, parenteral nutrition or dialysis...
March 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29682387/surgical-management-of-encapsulating-peritoneal-sclerosis-a-case-report-in-kidney-transplant-patient
#13
R Shahbazov, M Talanian, J L Alejo, F Azari, A Agarwal, K L Brayman
Introduction: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome of progressive fibrotic change in response to prolonged, repetitive, and typically severe insult to the peritoneal mesothelium, often occurring in the setting of peritoneal dialysis (PD). Clear guidelines for successful management remain elusive. We describe the successful surgical management of EPS in a 28-year-old male s/p deceased donor kidney transplant for end-stage renal disease (ESRD) secondary to focal segmental glomerulosclerosis (FSGS)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29673501/association-of-sarcopenia-with-nutritional-parameters-quality-of-life-hospitalization-and-mortality-rates-of-elderly-patients-on-hemodialysis
#14
Juliana Giglio, Maria Ayako Kamimura, Fernando Lamarca, Juliana Rodrigues, Fernanda Santin, Carla Maria Avesani
OBJECTIVE: This study aimed to assess whether diminished muscle mass, diminished muscle strength, or both conditions (sarcopenia) are associated with worse nutritional status, poor quality of life (QoL), and hard outcomes, such as hospitalization and mortality, in elderly patients on maintenance hemodialysis (MHD). DESIGN AND SUBJECTS: This is a multicenter observational longitudinal study that included 170 patients on MHD (age 70 ± 7 years, 65% male) from 6 dialysis centers...
May 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29665795/design-and-methods-of-the-removal-hd-study-a-trial-evaluating-mid-cut-off-value-membrane-clearance-of-albumin-and-light-chains-in-haemodialysis-patients
#15
R Krishnasamy, C M Hawley, M J Jardine, M A Roberts, Y J Cho, M G Wong, A Heath, C L Nelson, S Sen, P F Mount, E M Pascoe, D Darssan, L A Vergara, P A Paul-Brent, N D Toussaint, D W Johnson, C A Hutchison
BACKGROUND: Removal of uraemic toxins is inadequate using current dialysis strategies. A new class of dialysis membranes have been developed that allow clearance of larger middle molecules. The REMOVAL-HD study (a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients) will address safety, efficacy and the impact on patient-centred outcomes with the use of a mid cut-off (MCO) dialyser in a chronic haemodialysis (HD) population. METHODS: REMOVAL-HD is an open label, prospective, non-randomised, single-arm, multi-centre device study in 85 chronic HD participants...
April 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29664189/hydration-and-nutritional-status-in-patients-on-home-dialysis-a-single-centre-study
#16
Janet S C Li, John Y H Chan, Mandy M Y Tai, So M Wong, S M Pang, Fanny Y F Lam, Carmen H M Chu, Chris S Y Ching, Joseph H S Wong, W L Chak
BACKGROUND: Over-hydration (OH) and malnutrition are prevalent among patients on dialysis therapy. The prevalence of OH and malnutrition as well as the risk factors associated with OH and malnutrition in our patients on home peritoneal dialysis (PD) and home haemodialysis (HD) are examined. DESIGN AND METHODS: This was a cross-sectional study. The hydration and nutritional status of the study groups were assessed by a Body Composition Monitor. Patients who were stable on home dialysis therapy for over one year were invited to participate...
April 17, 2018: Journal of Renal Care
https://www.readbyqxmd.com/read/29657203/the-development-of-malnutrition-is-not-dependent-on-its-traditional-contributing-factors-in-patients-on-maintenance-hemodialysis-in-developing-countries
#17
Syed Rizwan Ali Bokhari, Mirza Ameer Faizan Ali, Syed Arsalan Khalid, Bushra Iftikhar, Hafiz Ijaz Ahmad, Ahlam Safdar Hussain, Usman Yaqoob
Malnutrition in dialysis population is associated with significant morbidity and mortality. Nutritional assessment is a neglected area in hemodialysis (HD) patients in developing countries. The aim of the study was to find out whether any traditional parameters have statistically significant correlation with malnutrition. All 58 end-stage renal disease patients on maintenance HD in our dialysis unit were enrolled in this cross-sectional study. The nutritional status was assessed by a predesigned questionnaire including subjective global assessment (SGA)...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29644065/frailty-and-chronic-kidney-disease-current-evidence-and-continuing-uncertainties
#18
Andrew C Nixon, Theodoros M Bampouras, Neil Pendleton, Alexander Woywodt, Sandip Mitra, Ajay Dhaygude
Frailty, the state of increased vulnerability to physical stressors as a result of progressive and sustained degeneration in multiple physiological systems, is common in those with chronic kidney disease (CKD). In fact, the prevalence of frailty in the older adult population is reported to be 11%, whereas the prevalence of frailty has been reported to be greater than 60% in dialysis-dependent CKD patients. Frailty is independently linked with adverse clinical outcomes in all stages of CKD and has been repeatedly shown to be associated with an increased risk of mortality and hospitalization...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29629982/end-of-life-care-in-icus-in-east-asia-a-comparison-among-china-korea-and-japan
#19
So Young Park, Jason Phua, Masaji Nishimura, Yiyun Deng, Yan Kang, Keiichi Tada, Younsuck Koh
OBJECTIVES: To compare physicians' perceptions and practice of end-of-life care in the ICU in three East Asian countries cultures similarly rooted in Confucianism. DESIGN: A structured and scenario-based survey of physicians who managed ICU patients from May 2012 to December 2012. SETTING: ICUs in China, Korea, and Japan. SUBJECTS: Specialists who are either intensivists or nonintensivist primary attending physicians in charge of patients (195 in China, 186 in Korea, 224 in Japan)...
April 6, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29620449/low-lean-tissue-mass-can-be-a-predictor-of-one-year-survival-in-hemodialysis-patients
#20
Aleksandra Rymarz, Julia Gibińska, Maria Zajbt, Wiesław Piechota, Stanisław Niemczyk
PURPOSE: Nutritional status has a significant impact on the outcomes in the dialysis population. The aim of this study was to evaluate the association between body composition and a one-year survival of hemodialysis patients. METHODS: Forty-eight patients with chronic kidney disease stage V treated with hemodialysis for more than three months were included. Body composition was assessed by bioimpedance spectroscopy (Body Composition Monitor, Fresenius Medical Care)...
November 2018: Renal Failure
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