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https://www.readbyqxmd.com/read/28104242/preconception-stress-and-the-secondary-sex-ratio-in-a-population-based-preconception-cohort
#1
Jisuk Bae, Courtney D Lynch, Sungduk Kim, Rajeshwari Sundaram, Katherine J Sapra, Germaine M Buck Louis
OBJECTIVE: To examine the association between preconception parental stress and the secondary sex ratio, defined as the ratio of males to females at birth. DESIGN: A population-based preconception cohort. SETTING: Not applicable. PATIENT(S): A total of 235 couples who were enrolled before conception in Michigan and Texas between 2005 and 2009 and who had a singleton birth during the follow-up period. Couples were interviewed separately at baseline to obtain information on perceived stress (Cohen's Perceived Stress Scale) and lifetime history of physician-diagnosed anxiety and/or mood disorders...
January 16, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28096200/family-history-of-breast-cancer-breast-density-and-breast-cancer-risk-in-a-u-s-breast-cancer-screening-population
#2
Thomas P Ahern, Brian L Sprague, Michael C S Bissell, Diana L Miglioretti, Diana S M Buist, Dejana Braithwaite, Karla Kerlikowske
BACKGROUND: The utility of incorporating detailed family history into breast cancer risk prediction hinges on its independent contribution to breast cancer risk. We evaluated associations between detailed family history and breast cancer risk while accounting for breast density. METHODS: We followed 222,019 participants aged 35-74 in the Breast Cancer Surveillance Consortium, of whom 2,456 developed invasive breast cancer. We calculated standardized breast cancer risks within joint strata of breast density and simple (1st-degree female relative) or detailed (1st-degree, 2nd-degree, or 1st- and 2nd-degree female relative) breast cancer family history...
January 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28095095/joint-association-of-complement-component-3-and-cc-cytokine-ligand2-ccl2-or-complement-component-3-and-cfh-polymorphisms-in-age-related-macular-degeneration
#3
Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Tahereh Mohammadian, Nikou Fotouhi, Alireza Javadzadeh, Masoud Soheilian
BACKGROUND: To determine the joint effect of complement component 3(C3 R102G) with CC-cytokine ligand2 (CCL2-2518) or complement factor H (CFH) Y402H polymorphisms on advanced age-related macular degeneration (AMD). METHODS: In this case-control study, 233 patients with advanced AMD and 159 unrelated healthy controls enrolled for evaluation. Selected polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: A combination of AA CCL2 (rs1024611) and GG C3 (R102G) genotypes resulted in a super-additivity of the risks: OR = 10...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28094189/medicaid-payer-status-is-linked-to-increased-rates-of-complications-after-treatment-of-proximal-humerus-fractures
#4
Vani J Sabesan, Graysen Petersen-Fitts, Daniel Lombardo, Daniel Briggs, James Whaley
BACKGROUND: Low socioeconomic status and Medicaid insurance as a primary payer have been associated with major disparities in resource utilization and risk-adjusted outcomes for patients undergoing total joint arthroplasty. With the expansion of Medicaid through the Affordable Care Act in 2014, examination of these disparities has become increasingly relevant for the treatment of proximal humerus fracture (PHF). METHODS: The Healthcare Cost and Utilization Project Nationwide Inpatient Sample database was used to identify patients who were treated for PHF from 2002 to 2012...
January 13, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28089978/rituximab-retreatment-in-rheumatoid-arthritis-in-a-real-life-cohort-data-from-the-cererra-collaboration
#5
Katerina Chatzidionysiou, Elisabeth Lie, Galina Lukina, Merete L Hetland, Ellen-Margrethe Hauge, Karel Pavelka, Cem Gabay, Almut Scherer, Dan Nordström, Helena Canhao, Maria José Santos, Matija Tomsic, Ziga Rotar, M Victoria Hernández, Juan Gomez-Reino, Ioan Ancuta, Tore K Kvien, Ronald van Vollenhoven
OBJECTIVE: Several aspects of rituximab (RTX) retreatment in rheumatoid arthritis (RA) need to be further elucidated. The aim of this study was to describe the effect of repeated courses of RTX on disease activity and to compare 2 retreatment strategies, fixed-interval versus on-flare retreatment, in a large international, observational, collaborative study. METHODS: In the first analysis, patients with RA who received at least 4 cycles with RTX were included. In the second analysis, patients who received at least 1 RTX retreatment and for whom information about the strategy for retreatment was available were identified...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089467/the-evolution-of-implant-design-decreases-the-incidence-of-lateral-release-in-primary-total-knee-arthroplasty
#6
Jonathan E Webb, Heidi Y Yang, Jamie E Collins, Elena Losina, Thomas S Thornhill, Jeffrey N Katz
BACKGROUND: Appropriate balancing of the patellofemoral joint (PFJ) using a lateral release can help to prevent patellar instability in total knee arthroplasty (TKA). Contemporary total knee implant designs are characterized by enhanced trochlear geometry more similar to native knee anatomy to minimize instability and reduce utilization of a lateral release. METHODS: We retrospectively reviewed consecutive TKA cases from a single senior surgeon's practice with 3 successive total knee designs: the Press-Fit Condylar (PFC), the Sigma, and the ATTUNE (DePuy, Warsaw, IN)...
December 14, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28086960/the-relationship-between-synovitis-quantified-by-an-ultrasound-7-joint-inflammation-score-and-physical-disability-in-rheumatoid-arthritis-a-cohort-study
#7
Jakub Závada, Petra Hánová, Jana Hurňáková, Lenka Szczuková, Michal Uher, Šárka Forejtová, Martin Klein, Herman Mann, Marta Olejárová, Olga Růžičková, Olga Šléglová, Karel Hejduk, Karel Pavelka
BACKGROUND: Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It is unknown, whether the extent of synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for physical functioning. To answer this question we investigated the longitudinal relationship between physical function assessed by the health assessment questionnaire (HAQ) and the German 7-joint ultrasound score (US7S) in a prospective cohort of patients with RA...
January 13, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28079030/neuromusculoskeletal-model-self-calibration-for-on-line-sequential-bayesian-moment-estimation
#8
Diana Ruiz Bueno, Luis Montano
OBJECTIVE: Neuromusculoskeletal models involve many subject-specific physiological parameters that need to be adjusted to adequately represent muscle properties. Traditionally, neuromusculoskeletal models have been calibrated with a forward-inverse dynamic optimization which is time-consuming and unfeasible for rehabilitation therapy. Non self-calibration algorithms have been applied to these models. To the best of our knowledge, the algorithm proposed in this work is the first on-line calibration algorithm for muscle models that allows a generic model to be adjusted to different subjects in a few steps...
January 12, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28075368/critical-windows-of-prenatal-exposure-to-cadmium-and-size-at-birth
#9
Lu Cheng, Bin Zhang, Tongzhang Zheng, Jie Hu, Aifen Zhou, Bryan A Bassig, Wei Xia, David A Savitz, Stephen Buka, Chao Xiong, Joseph M Braun, Yaqi Zhang, Yanqiu Zhou, Xinyun Pan, Chuansha Wu, Youjie Wang, Zhengmin Qian, Aimin Yang, Megan E Romano, Kunchong Shi, Shunqing Xu, Yuanyuan Li
Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. We measured Cd concentrations in urine samples at or near 13, 24, and 35 gestational weeks from 282 women in Wuhan, China. We used generalized estimating equation models to assess the associations between maternal creatinine adjusted urinary Cd concentrations at each trimester and birth size. A significant inverse association was observed between higher maternal Cd levels measured during the 1st trimester and birth size in girls...
January 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28074600/analyzing-multiple-endpoints-in-a-confirmatory-randomized-clinical-trial-an-approach-that-addresses-stratification-missing-values-baseline-imbalance-and-multiplicity-for-strictly-ordinal-outcomes
#10
Hengrui Sun, Atsushi Kawaguchi, Gary Koch
Confirmatory randomized clinical trials with a stratified design may have ordinal response outcomes, ie, either ordered categories or continuous determinations that are not compatible with an interval scale. Also, multiple endpoints are often collected when 1 single endpoint does not represent the overall efficacy of the treatment. In addition, random baseline imbalances and missing values can add another layer of difficulty in the analysis plan. Therefore, the development of an approach that provides a consolidated strategy to all issues collectively is essential...
January 11, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28072630/bracing-of-the-reconstructed-and-osteoarthritic-knee-during-high-dynamic-load-tasks
#11
Harvi F Hart, Kay M Crossley, Natalie J Collins, David C Ackland
PURPOSE: Lateral compartment osteoarthritis accompanied by abnormal knee biomechanics are frequently reported in individuals with knee osteoarthritis after anterior cruciate ligament reconstruction (ACLR). The aim of this study was to evaluate changes in knee biomechanics produced by an adjusted and unadjusted varus knee brace during high dynamic loading activities in individuals with lateral knee osteoarthritis after ACLR and valgus malalignment. METHODS: Nineteen participants who had undergone ACLR 5 to 20 years previously and had symptomatic and radiographic lateral knee osteoarthritis with valgus malalignment were assessed...
January 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28069970/lung-cancer-risk-in-welders-and-foundry-workers-with-a-history-of-heavy-smoking-in-the-usa-the-national-lung-screening-trial
#12
Jason Y Y Wong, Bryan A Bassig, Wei Jie Seow, Wei Hu, Bu-Tian Ji, Aaron Blair, Debra T Silverman, Qing Lan
OBJECTIVES: Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer risk in heavy smokers. METHODS: We analysed data from the National Lung Screening Trial, a prospective randomised trial of 53 454 heavy smokers (>30 pack-years) in the USA...
January 9, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28068972/an-underlying-diagnosis-of-osteonecrosis-of-bone-is-associated-with-worse-outcomes-than-osteoarthritis-after-total-hip-arthroplasty
#13
Jasvinder A Singh, Jason Chen, Maria C S Inacio, Robert S Namba, Elizabeth W Paxton
BACKGROUND: Well-designed studies of complications and readmission rates in patients undergoing total hip arthroplasty (THA) with osteonecrosis are lacking. Our objective was to examine if a diagnosis of osteonecrosis was associated with complications, mortality and readmission rates after THA. METHODS: We analyzed prospectively collected data from an integrated healthcare system's Total Joint Replacement Registry of adults with osteonecrosis vs. osteoarthritis (OA) undergoing unilateral primary THA during 2001-2012, in an observational cohort study...
January 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28068293/a-hybrid-bmi-based-exoskeleton-for-paresis-emg-control-for-assisting-arm-movements
#14
Toshihiro Kawase, Takeshi Sakurada, Yasuharu Koike, Kenji Kansaku
OBJECTIVE: Brain-machine interface (BMI) technologies have succeeded in controlling robotic exoskeletons, enabling some paralyzed people to control their own arms and hands. We have developed an exoskeleton asynchronously controlled by EEG signals. In this study, to enable real-time control of the exoskeleton for paresis, we developed a hybrid system with EEG and EMG signals, and the EMG signals were used to estimate its joint angles. APPROACH: Eleven able-bodied subjects and two patients with upper cervical spinal cord injuries (SCIs) performed hand and arm movements, and the angles of the metacarpophalangeal (MP) joint of the index finger, wrist, and elbow were estimated from EMG signals using a formula that we derived to calculate joint angles from EMG signals, based on a musculoskeletal model...
January 9, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28065381/the-contribution-of-3d-quantitative-meniscal-and-cartilage-measures-to-variation-in-normal-radiographic-joint-space-width-data-from-the-osteoarthritis-initiative-healthy-reference-cohort
#15
Melanie Roth, Wolfgang Wirth, Katja Emmanuel, Adam G Culvenor, Felix Eckstein
OBJECTIVE: To explore to what extent three-dimensional measures of the meniscus and femorotibial cartilage explain the variation in medial and lateral femorotibial radiographic joint space width (JSW), in healthy men and women. METHODS: The right knees of 87 Osteoarthritis Initiative healthy reference participants (no symptoms, radiographic signs or risk factors of osteoarthritis; 37 men, 50 women; age 55.0±7.6; BMI 24.4±3.1) were assessed. Quantitative measures of subregional femorotibial cartilage thickness and meniscal position and morphology were computed from segmented magnetic resonance images...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28063976/effect-of-jaw-opening-exercise-on-prevention-of-temporomandibular-disorders-pain-associated-with-oral-appliance-therapy-in-obstructive-sleep-apnea-patients-a-randomized-double-blind-placebo-controlled-trial
#16
Hiroyuki Ishiyama, Shusuke Inukai, Akira Nishiyama, Masayuki Hideshima, Shuhei Nakamura, Meiyo Tamaoka, Yasunari Miyazaki, Kenji Fueki, Noriyuki Wakabayashi
PURPOSE: There are no studies on the prevention of temporomandibular joint and/or masticatory muscle pain (TMD pain) associated with oral appliance (OA) therapy in patients with obstructive sleep apnea (OSA). The aim of this study was to determine the effect of jaw-opening exercise on TMD pain associated with OA therapy in OSA patients. METHODS: Twenty-five OSA patients without pain-related TMD were consecutively enrolled into a two-arm, randomized, double-blind, placebo-controlled trial...
January 4, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28062627/association-of-repeatedly-measured-high-sensitivity-assayed-troponin-i-with-cardiovascular-disease-events-in-a-general-population-from-the-morgam-biomarcare-study
#17
Maria F Hughes, Francisco Ojeda, Olli Saarela, Torben Jørgensen, Tanja Zeller, Tarja Palosaari, Mark G O'Doherty, Anders Borglykke, Kari Kuulasmaa, Stefan Blankenberg, Frank Kee
BACKGROUND: High-sensitivity troponin I (hs-cTnI) concentrations reflect myocardial stress. The role of hs-cTnI in predicting long-term changes in the risk of cardiovascular disease (CVD) in general populations is not clearly defined. METHODS: We investigated whether the change in 3 repeated measures of hs-cTnI collected 5 years apart in a prospective Danish study (3875 participants, initially aged 30-60 years, 51% female, disease free at baseline) improves 10-year prediction of incident CVD compared to using a single most recent hs-cTnI measurement...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28061494/prevalence-and-risk-factors-for-lumbar-spondylosis-and-its-association-with-low-back-pain-among-rural-korean-residents
#18
Sung Yeon Lee, Nam H Cho, Young Ok Jung, Young Il Seo, Hyun Ah Kim
OBJECTIVE: The purpose of this study was to investigate the prevalence of and the relevant risk factors for lumbar spondylosis (LS) among middle-aged and elderly rural Korean residents and to explore the association between radiographic LS and lower back pain (LBP) in relation to age and gender. METHODS: This community-based, cross-sectional study evaluated 1512 subjects with available radiograph. The prevalence of LBP was obtained using a questionnaire and disability resulting from LBP was measured using a validated Korean version of the Oswestry disability index (ODI)...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28060994/joint-association-of-multimorbidity-and-work-ability-with-risk-of-long-term-sickness-absence-a-prospective-cohort-study-with-register-follow-up
#19
Emil Sundstrup, Markus Due Jakobsen, Ole Steen Mortensen, Lars Louis Andersen
Objectives The aim of this study was to determine the joint association of multimorbidity and work ability with the risk of long-term sickness absence (LTSA) in the general working population. Methods Cox regression analysis censoring for competing events (statutory retirement, early retirement, disability pension, immigration, or death) was performed to estimate the joint association of chronic diseases and work ability in relation to physical and mental demands of the job with the prospective risk for LTSA (defined as ≥6 consecutive weeks during 2-year follow-up) among 10 427 wage earners from the general working population (2010 Danish Work Environment Cohort Study)...
January 6, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28060228/risk-adjusted-hospital-outcomes-in-medicare-total-joint-replacement-surgical-procedures
#20
Donald E Fry, Michael Pine, Susan M Nedza, David G Locke, Agnes M Reband, Gregory Pine
BACKGROUND: Comparative measurement of hospital outcomes can define opportunities for care improvement and will assume great importance as alternative payment models for inpatient total joint replacement surgical procedures are introduced. The purpose of this study was to develop risk-adjusted models for Medicare inpatient and post-discharge adverse outcomes in elective lower-extremity total joint replacement and to apply these models for hospital comparison. METHODS: Hospitals with ≥50 qualifying cases of elective total hip replacement and total knee replacement from the Medicare Limited Data Set database of 2010 to 2012 were studied...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
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