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https://www.readbyqxmd.com/read/28529867/efficacy-of-antibiotic-suppressive-therapy-in-patients-with-a-prosthetic-joint-infection
#1
Marjan Wouthuyzen-Bakker, Jasperina M Nijman, Greetje A Kampinga, Sander van Assen, Paul C Jutte
Introduction: For chronic prosthetic joint infections (PJI), complete removal of the infected prosthesis is necessary in order to cure the infection. Unfortunately, a subgroup of patients is not able to undergo a revision surgery due to high surgical risk. Alternatively, these patients can be treated with antibiotic suppressive therapy (AST) to suppress the infection. Aim: To evaluate the efficacy and tolerability of AST. Methods: We retrospectively collected data (period 2009-2015) from patients with a PJI (of hip, knee or shoulder) who were treated with AST at the University Medical Center Groningen, the Netherlands...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28526023/high-incidence-of-periprosthetic-joint-infection-with-propionibacterium-acnes-after-the-use-of-a-stemless-shoulder-prosthesis-with-metaphyseal-screw-fixation-a-retrospective-cohort-study-of-241-patients-propionibacter-infections-after-eclipse-tsa
#2
Lisa Johansson, Nils P Hailer, Hans Rahme
BACKGROUND: A stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (Eclipse®). The aim of this study was to analyze whether the risk of infection is different with this implant compared to conventional shoulder prosthesis. METHODS: Two hundred and forty-one patients (54.8% females) were operated with a shoulder arthroplasty and followed for median 2.0 (0...
May 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28525629/the-association-of-perceived-memory-loss-with-osteoarthritis-and-related-joint-pain-in-a-large-appalachian-population
#3
Kim E Innes, Usha Sambamoorthi
Objective. : Previous studies have documented memory impairment in several chronic pain syndromes. However, the potential link between memory loss and osteoarthritis (OA), the second most common cause of chronic pain, remains little explored. In this cross-sectional study, we examine the association of perceived memory loss to OA and assess the potential mediating influence of sleep and mood disturbance in a large Appalachian population. Design.:  Cross-sectional...
May 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28523978/closed-loop-neuromodulation-systems-next-generation-treatments-for-psychiatric-illness
#4
Meng-Chen Lo, Alik S Widge
Despite deep brain stimulation's positive early results in psychiatric disorders, well-designed clinical trials have yielded inconsistent clinical outcomes. One path to more reliable benefit is closed-loop therapy: stimulation that is automatically adjusted by a device or algorithm in response to changes in the patient's electrical brain activity. These interventions may provide more precise and patient-specific treatments. This article first introduces the available closed-loop neuromodulation platforms, which have shown clinical efficacy in epilepsy and strong early results in movement disorders...
April 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28522282/quality-indicators-for-the-use-of-systemic-antibiotics-in-dentistry
#5
Rugzan Jameel Hussein, Robert Krohn, Petra Kaufmann-Kolle, Gerald Willms
BACKGROUND: Risks resulted from using systemic antibiotics such as increasing rates of bacterial resistance, allergy and side effects should be always weighed individually for each patient against any potential benefits. Routine antibiotic prescribing must be therefore discouraged. The Federal Joint Committee ("Gemeinsamer Bundesauschuss", G-BA) commissioned the AQUA-Institute with the development of an external quality assurance procedure, examining systemic antibiotic use in periodontal, conservative and surgical treatments in ambulatory dental health care...
May 15, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28521834/incidence-of-total-hip-or-knee-replacement-due-to-osteoarthritis-in-relation-to-thyroid-function-a-prospective-cohort-study-the-nord-tr%C3%A3-ndelag-health-study
#6
Alf Inge Hellevik, Marianne Bakke Johnsen, Arnulf Langhammer, Anne Marie Fenstad, Ove Furnes, Kjersti Storheim, John Anker Zwart, Gunnar Flugsrud, Lars Nordsletten
BACKGROUND: To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. METHODS: In a prospective cohort study, data from the second and third survey of the Nord-Trøndelag Health Study were linked to the Norwegian Arthroplasty Register in order to identify total hip or knee replacement as a result of primary osteoarthritis. RESULTS: Among 37 891 participants without previously known thyroid disease we recorded 978 total hip replacements (THRs) and 538 total knee replacements (TKRs) during a median follow-up time of 15...
May 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28512340/using-an-event-history-with-risk-free-model-to-study-the-genetics-of-alcoholism
#7
Hsin-Chou Yang, I-Chen Chen, Yuh-Chyuan Tsay, Zheng-Rong Li, Chun-Houh Chen, Hai-Gwo Hwu, Chen-Hsin Chen
Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously characterize alcoholism susceptibility and onset age in 65 independent non-Hispanic Caucasian males in the Collaborative Study on the Genetics of Alcoholism. Following data quality control, we analysed 22 single nucleotide polymorphisms (SNPs) on 12 candidate genes...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511081/a-novel-ultrasonic-surface-machining-tool-utilizing-elastic-traveling-waves
#8
Ruinan Ji, Jiamei Jin, Liang Wang, Jianhui Zhang
With the rapid development of modern industrial technology and high performance technology products, ultra-precision machining technology becomes increasingly important. However, joint clearance of kinematic pairs, lack of feeding accuracy and overlarge contact stress still limit the further improvement of ultra-precision machining technology. In this study, a novel surface machining method utilizing structural elastic waves was proposed, and a machining tool using the piezoelectric actuating principle was presented for verifying the proposed method...
May 4, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28510594/long-term-type-1-diabetes-is-associated-with-hand-pain-disability-and-stiffness-but-not-with-structural-hand-osteoarthritis-features-the-dialong-hand-study
#9
Karin Magnusson, Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kåre Birger Hagen, Ida Kristin Haugen, Tore Julsrud Berg
OBJECTIVE: To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness. METHODS: In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included (mean [SD] age: 62.2 [7.4], mean [SD] HbA1c: 7.43 [0.80] and N = 49 [51%] men). Regular measurements of their HbA1c were obtained till 2015. We included N = 69 healthy controls without any diabetes (mean [SD] age: 63...
2017: PloS One
https://www.readbyqxmd.com/read/28509584/the-influence-of-the-crutch-setup-on-stability-and-weight-bearing-parameters-in-post-total-hip-replacement-surgery-patients-during-quiet-standing
#10
Francesco Esposito, Marco Freddolini, Leonardo Latella, Palmina Braccio, Massimiliano Marcucci, Andrea Corvi
PURPOSE: The purpose of this study is to evaluate the influence of the crutch setup on standing, in post total hip replacement (THR) surgery patients. MATERIALS AND METHODS: Thirty patients after THR were randomly assigned to walking with the elbow flexed (EF) or elbow straight (ES) crutch setup. Subjects were asked to stand on a force platform in a comfortable position with the crutch positioned on the unaffected side, facing forward for 10 seconds. Centre of pressure total path and maximal excursion were evaluated in both medio-lateral and anterior-posterior planes...
May 16, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28506843/longitudinal-association-between-foot-and-ankle-symptoms-and-worsening-of-symptomatic-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#11
Kade L Paterson, Jessica Kasza, David J Hunter, Rana S Hinman, Hylton B Menz, George Peat, Kim L Bennell
OBJECTIVE: To assess whether foot and/or ankle symptoms are associated with an increased risk of worsening of knee pain and radiographic change in people with knee osteoarthritis (OA). METHODS: The presence and laterality of foot/ankle symptoms were recorded at baseline in 1368 participants from the Osteoarthritis Initiative with symptomatic radiographic knee OA. Knee pain severity (measured using the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale) and minimum medial tibiofemoral joint space (minJSW) width measured on x-ray were assessed yearly over the subsequent four years...
May 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28504931/robust-real-time-musculoskeletal-modeling-driven-by-electromyograms
#12
Guillaume Durandau, Dario Farina, Massimo Sartori
OBJECTIVE: Current clinical biomechanics involves lengthy data acquisition and time-consuming offline analyses and current biomechanical models cannot be used for real-time control in man-machine interfaces. We developed a method that enables online analysis of neuromusculoskeletal function in vivo in the intact human. METHODS: We used electromyography (EMG)-driven musculoskeletal modeling to simulate all transformations from muscle excitation onset (EMGs) to mechanical moment production around multiple lower-limb degrees of freedom (DOFs)...
May 12, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28504051/modeling-qrt-pcr-dynamics-with-application-to-cancer-biomarker-quantification
#13
Inna Chervoneva, Boris Freydin, Terry Hyslop, Scott A Waldman
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) is widely used for molecular diagnostics and evaluating prognosis in cancer. The utility of mRNA expression biomarkers relies heavily on the accuracy and precision of quantification, which is still challenging for low abundance transcripts. The critical step for quantification is accurate estimation of efficiency needed for computing a relative qRT-PCR expression. We propose a new approach to estimating qRT-PCR efficiency based on modeling dynamics of polymerase chain reaction amplification...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28503144/rigid-ankle-foot-orthosis-deteriorates-mediolateral-balance-control-and-vertical-braking-during-gait-initiation
#14
Arnaud Delafontaine, Olivier Gagey, Silvia Colnaghi, Manh-Cuong Do, Jean-Louis Honeine
Rigid ankle-foot orthoses (AFO) are commonly used for impeding foot drop during the swing phase of gait. They also reduce pain and improve gait kinematics in patients with weakness or loss of integrity of ankle-foot complex structures due to various pathological conditions. However, this comes at the price of constraining ankle joint mobility, which might affect propulsive force generation and balance control. The present study examined the effects of wearing an AFO on biomechanical variables and electromyographic activity of tibialis anterior (TA) and soleus muscles during gait initiation (GI)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28502884/quantifying-sex-race-and-age-specific-differences-in-bone-microstructure-requires-measurement-of-anatomically-equivalent-regions
#15
Ali Ghasem-Zadeh, Andrew Burghardt, Xiao-Fang Wang, Sandra Iuliano, Serena Bonaretti, Minh Bui, Roger Zebaze, Ego Seeman
INTRODUCTION: Individuals differ in forearm length. As microstructure differs along the radius, we hypothesized that errors may occur when sexual and racial dimorphisms are quantified at a fixed distance from the radio-carpal joint. METHODS: Microstructure was quantified ex vivo in 18 cadaveric radii using high resolution peripheral quantitative computed tomography and in vivo in 158 Asian and Caucasian women and men at a fixed region of interest (ROI), a corrected ROI positioned at 4...
May 11, 2017: Bone
https://www.readbyqxmd.com/read/28502778/the-joint-association-of-insulin-sensitivity-and-physical-activity-on-the-skeletal-muscle-mass-and-performance-in-community-dwelling-older-adults
#16
Chuan-Wei Yang, Chia-Ing Li, Tsai-Chung Li, Chiu-Shong Liu, Chih-Hsueh Lin, Wen-Yuan Lin, Cheng-Chieh Lin
BACKGROUND: Many well-known risk factors that may lead to sarcopenia are already discovered. However, their combined effects on sarcopenia components remain unclear. This study aims to explore the joint association of physical activity and insulin sensitivity on skeletal muscle mass and performance of Taiwanese elder people from a metropolitan community. METHODS: The study sample involved 844 elders who were examined through dual energy X-ray absorptiometry and who underwent tests for fasting blood glucose and serum insulin level...
May 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28501732/asymmetrical-stabilization-and-mobilization-exploited-during-static-single-leg-stance-and-goal-directed-kicking
#17
Adam C King, Zheng Wang
The motor control properties of the right and left legs are dependent on the stabilization and mobilization features of the motor tasks. The current investigation examined the right and left leg control differences - interlateral asymmetries - during static single leg stance and dynamic goal directed kicking with an emphasis of the asymmetrical stabilization and mobilization components of movements. Ten young, healthy, right-leg preferred individuals with minimal kicking experience completed both tests on each limb...
May 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28500919/kinetics-of-circulating-fetuin-a-may-predict-mortality-independently-from-adiponectin-high-molecular-weight-adiponectin-and-prognostic-factors-in-critically-ill-patients-with-sepsis-a-prospective-study
#18
Irene Karampela, Evangelia Kandri, Georgios Antonakos, Evangelos Vogiatzakis, Gerasimos Socrates Christodoulatos, Athina Nikolaidou, George Dimopoulos, Apostolos Armaganidis, Maria Dalamaga
PURPOSE: Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis. MATERIALS AND METHODS: In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender...
May 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28497531/exposure-enriched-outcome-dependent-designs-for-longitudinal-studies-of-gene-environment-interaction
#19
Zhichao Sun, Bhramar Mukherjee, Jason P Estes, Pantel S Vokonas, Sung Kyun Park
Joint effects of genetic and environmental factors have been increasingly recognized in the development of many complex human diseases. Despite the popularity of case-control and case-only designs, longitudinal cohort studies that can capture time-varying outcome and exposure information have long been recommended for gene-environment (G × E) interactions. To date, literature on sampling designs for longitudinal studies of G × E interaction is quite limited. We therefore consider designs that can prioritize a subsample of the existing cohort for retrospective genotyping on the basis of currently available outcome, exposure, and covariate data...
May 11, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28496296/a-systematic-review-of-the-literature-on-parenting-of-young-children-with-visual-impairments-and-the-adaptions-for-video-feedback-intervention-to-promote-positive-parenting-vipp
#20
REVIEW
Ellen G C van den Broek, Ans J P M van Eijden, Mathilde M Overbeek, Sabina Kef, Paula S Sterkenburg, Carlo Schuengel
Secure parent-child attachment may help children to overcome the challenges of growing up with a visual or visual-and-intellectual impairment. A large literature exists that provides a blueprint for interventions that promote parental sensitivity and secure attachment. The Video-feedback Intervention to promote Positive Parenting (VIPP) is based on that blueprint. While it has been adapted to several specific at risk populations, children with visual impairment may require additional adjustments. This study aimed to identify the themes that should be addressed in adapting VIPP and similar interventions...
2017: Journal of Developmental and Physical Disabilities
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