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https://www.readbyqxmd.com/read/28431220/contribution-of-ankle-foot-orthosis-moment-in-regulating-ankle-and-knee-motions-during-gait-in-individuals-post-stroke
#1
Toshiki Kobayashi, Michael S Orendurff, Madeline L Singer, Fan Gao, K Bo Foreman
BACKGROUND: Ankle-foot orthosis moment resisting plantarflexion has systematic effects on ankle and knee joint motion in individuals post-stroke. However, it is not known how much ankle-foot orthosis moment is generated to regulate their motion. The aim of this study was to quantify the contribution of an articulated ankle-foot orthosis moment to regulate ankle and knee joint motion during gait in individuals post-stroke. METHODS: Gait data were collected from 10 individuals post-stroke using a Bertec split-belt instrumented treadmill and a Vicon 3-dimensional motion analysis system...
April 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28430901/synergistic-effect-between-ischaemic-heart-disease-and-common-mental-disorders-and-the-risk-of-premature-exit-from-the-labour-market-a-nationwide-register-based-study-from-sweden
#2
Ellenor Mittendorfer-Rutz, Torbjörn Ivert, Marjan Vaez, Thomas Ernst Dorner
Aims: Common mental disorders i.e. depressive and anxiety disorders (CMD) are frequent comorbid conditions in individuals with ischaemic heart disease (IHD). Still, their effect on preterm exit from the labour market [i.e. disability pension (DP)] in individuals with IHD has to date not been scrutinized. The aim of this study was to investigate the separate and joint effect of IHD and CMD on the risk of DP for women and men of working age. Material and methods: This population-based cohort study included all non-pensioned 4 823 069 individuals, registered as living in Sweden 31 December 2004 and then 16-64 years of age...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28430847/invited-commentary-bias-attenuation-and-identification-of-causal-effects-with-multiple-negative-controls
#3
Wang Miao, Eric Tchetgen Tchetgen
In this commentary, we describe several extensions to the interesting and important negative control exposure approach for partial confounding adjustment in time-series analysis proposed by Flanders et al. (Am J Epidemiol. 2012;000(0):000-000). Specifically, by leveraging the availability of exposure time series, we show that under certain additional fairly reasonable assumptions, one can incorporate both past and future exposures as multiple negative control exposures to further attenuate confounding bias...
April 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28430825/discovery-and-fine-mapping-of-adiposity-loci-using-high-density-imputation-of-genome-wide-association-studies-in-individuals-of-african-ancestry-african-ancestry-anthropometry-genetics-consortium
#4
Maggie C Y Ng, Mariaelisa Graff, Yingchang Lu, Anne E Justice, Poorva Mudgal, Ching-Ti Liu, Kristin Young, Lisa R Yanek, Mary F Feitosa, Mary K Wojczynski, Kristin Rand, Jennifer A Brody, Brian E Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, Leslie A Lange, Michael A Nalls, Hayrettin Okut, Salman M Tajuddin, Bamidele O Tayo, Sailaja Vedantam, Jonathan P Bradfield, Guanjie Chen, Wei-Min Chen, Alessandra Chesi, Marguerite R Irvin, Badri Padhukasahasram, Jennifer A Smith, Wei Zheng, Matthew A Allison, Christine B Ambrosone, Elisa V Bandera, Traci M Bartz, Sonja I Berndt, Leslie Bernstein, William J Blot, Erwin P Bottinger, John Carpten, Stephen J Chanock, Yii-Der Ida Chen, David V Conti, Richard S Cooper, Myriam Fornage, Barry I Freedman, Melissa Garcia, Phyllis J Goodman, Yu-Han H Hsu, Jennifer Hu, Chad D Huff, Sue A Ingles, Esther M John, Rick Kittles, Eric Klein, Jin Li, Barbara McKnight, Uma Nayak, Barbara Nemesure, Adesola Ogunniyi, Andrew Olshan, Michael F Press, Rebecca Rohde, Benjamin A Rybicki, Babatunde Salako, Maureen Sanderson, Yaming Shao, David S Siscovick, Janet L Stanford, Victoria L Stevens, Alex Stram, Sara S Strom, Dhananjay Vaidya, John S Witte, Jie Yao, Xiaofeng Zhu, Regina G Ziegler, Alan B Zonderman, Adebowale Adeyemo, Stefan Ambs, Mary Cushman, Jessica D Faul, Hakon Hakonarson, Albert M Levin, Katherine L Nathanson, Erin B Ware, David R Weir, Wei Zhao, Degui Zhi, Donna K Arnett, Struan F A Grant, Sharon L R Kardia, Olufunmilayo I Oloapde, D C Rao, Charles N Rotimi, Michele M Sale, L Keoki Williams, Babette S Zemel, Diane M Becker, Ingrid B Borecki, Michele K Evans, Tamara B Harris, Joel N Hirschhorn, Yun Li, Sanjay R Patel, Bruce M Psaty, Jerome I Rotter, James G Wilson, Donald W Bowden, L Adrienne Cupples, Christopher A Haiman, Ruth J F Loos, Kari E North
Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified through screening of the African ancestry genomes. We performed large scale meta-analyses and replications in up to 52,895 individuals for BMI and up to 23,095 individuals for WHRadjBMI from the African Ancestry Anthropometry Genetics Consortium (AAAGC) using 1000 Genomes phase 1 imputed GWAS to improve coverage of both common and low frequency variants in the low linkage disequilibrium African ancestry genomes...
April 21, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28427313/sensitivity-of-a-juvenile-subject-specific-musculoskeletal-model-of-the-ankle-joint-to-the-variability-of-operator-dependent-input
#5
Iain Hannah, Erica Montefiori, Luca Modenese, Joe Prinold, Marco Viceconti, Claudia Mazzà
Subject-specific musculoskeletal modelling is especially useful in the study of juvenile and pathological subjects. However, such methodologies typically require a human operator to identify key landmarks from medical imaging data and are thus affected by unavoidable variability in the parameters defined and subsequent model predictions. The aim of this study was to thus quantify the inter- and intra-operator repeatability of a subject-specific modelling methodology developed for the analysis of subjects with juvenile idiopathic arthritis...
May 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28423061/muscle-contributions-to-medial-tibiofemoral-compartment-contact-loading-following-acl-reconstruction-using-semitendinosus-and-gracilis-tendon-grafts
#6
Jason M Konrath, David J Saxby, Bryce A Killen, Claudio Pizzolato, Christopher J Vertullo, Rod S Barrett, David G Lloyd
BACKGROUND: The muscle-tendon properties of the semitendinosus (ST) and gracilis (GR) are substantially altered following tendon harvest for the purpose of anterior cruciate ligament reconstruction (ACLR). This study adopted a musculoskeletal modelling approach to determine how the changes to the ST and GR muscle-tendon properties alter their contribution to medial compartment contact loading within the tibiofemoral joint in post ACLR patients, and the extent to which other muscles compensate under the same external loading conditions during walking, running and sidestep cutting...
2017: PloS One
https://www.readbyqxmd.com/read/28420718/sex-bmi-and-age-differences-in-metabolic-syndrome-the-dutch-lifelines-cohort-study
#7
Sandra Nicole Slagter, Robert P van Waateringe, André P van Beek, Melanie M van der Klauw, Bruce H R Wolffenbuttel, Jana V van Vliet-Ostaptchouk
INTRODUCTION: To evaluate the prevalence of metabolic syndrome (MetS) and its individual components within sex-, body mass index (BMI)- and age combined clusters. In addition, we used the diagnostic age-adjusted blood pressure thresholds to demonstrate the effect on the prevalence of MetS and elevated blood pressure. SUBJECTS AND METHODS: Cross-sectional data from 74,531 western European participants, aged 18-79 years, was used from the Dutch Lifelines Cohort Study...
April 18, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28420579/clustering-of-cardio-metabolic-risk-factors-in-iranian-adult-population-a-growing-problem-in-the-north-of-iran
#8
K Hajian-Tilaki, B Heidari, A R Firouzjahi
INTRODUCTION: The clustering of components of metabolic syndrome (MetS) is a major concern in a transition population because of dramatic changing toward modern life styles. The objective of this study was to determine the prevalence of clustering of various combinations of MetS and its association with obesity. METHODS AND SUBJECTS: In a population- based cross-sectional study, a representative samples of 1000 adults were recruited in Babol, the north of Iran. The demographic data, blood pressure, body mass index and waist circumference (WC) were measured with standard method...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28419629/motivational-and-behavioural-models-of-change-a-longitudinal-analysis-of-change-among-men-with-chronic-haemophilia-related-joint-pain
#9
J Elander, C Richardson, J Morris, G Robinson, M B Schofield
BACKGROUND: Motivational and behavioural models of adjustment to chronic pain make different predictions about change processes, which can be tested in longitudinal analyses. METHODS: We examined changes in motivation, coping and acceptance among 78 men with chronic haemophilia-related joint pain. Using cross-lagged regression analyses of changes from baseline to 6 months as predictors of changes from 6 to 12 months, with supplementary structural equation modelling, we tested two models in which motivational changes influence behavioural changes, and one in which behavioural changes influence motivational changes...
April 17, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28418898/plce1-polymorphisms-and-expression-combined-with-serum-afp-level-predicts-survival-of-hbv-related-hepatocellular-carcinoma-patients-after-hepatectomy
#10
Xiwen Liao, Chuangye Han, Wei Qin, Xiaoguang Liu, Long Yu, Guangzhi Zhu, Tingdong Yu, Sicong Lu, Hao Su, Zhen Liu, Zhiwei Chen, Chengkun Yang, Ketuan Huang, Zhengtao Liu, Yu Liang, Jianlu Huang, Jiahong Dong, Lequn Li, Xue Qin, Xinping Ye, Kaiyin Xiao, Minhao Peng, Tao Peng
Polymorphisms in the phospholipase C epsilon (PLCE) 1 gene play a crucial role in the development and progression of several types of cancer. The present study investigated the prognostic significance of PLCE1 gene polymorphisms and expression combined with serum α-fetoprotein (AFP) level in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Single nucleotide polymorphisms were genotyped by sequencing DNA isolated from surgically resected tumor samples of 421 HBV-related HCC patients, and expression profiles were generated based on the GSE14520 dataset...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418893/locoregionally-recurrent-head-and-neck-squamous-cell-carcinoma-incidence-survival-prognostic-factors-and-treatment-outcomes
#11
Jer-Hwa Chang, Chia-Che Wu, Kevin Sheng-Po Yuan, Alexander T H Wu, Szu-Yuan Wu
PURPOSE: For locoregionally recurrent head and neck squamous cell carcinoma (HNSCC), appropriate therapeutic decisions remain unclear. We examined the treatment outcomes of a national cohort to determine suitable treatments for and prognostic factors in patients with locoregionally recurrent HNSCCs at different stages and sites. PATIENTS AND METHODS: We analyzed data of >20-year-old patients with HNSCC at American Joint Committee on Cancer clinical stages I-IV without metastasis from Taiwan National Health Insurance and cancer registry databases...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418810/relationship-of-trochlear-morphology-and-patellofemoral-joint-alignment-to-superolateral-hoffa-fat-pad-edema-on-mr-images-in-individuals-with-or-at-risk-for-osteoarthritis-of-the-knee-the-most-study
#12
Rafael Widjajahakim, Michael Roux, Mohamed Jarraya, Frank W Roemer, Tuhina Neogi, John A Lynch, Cora E Lewis, James C Torner, David T Felson, Ali Guermazi, Joshua J Stefanik
Purpose To determine the relationship of patellofemoral joint alignment and trochlear morphology to superolateral Hoffa fat pad (SHFP) edema on magnetic resonance (MR) images in older adults with or at risk for osteoarthritis of the knee. Materials and Methods Institutional review board approval and written informed consent were obtained from all subjects. The Multicenter Osteoarthritis Study is a prospective cohort study of older adults with or at risk for osteoarthritis of the knee. Subjects were recruited from Birmingham, Alabama, and Iowa City, Iowa...
April 17, 2017: Radiology
https://www.readbyqxmd.com/read/28417944/variable-admittance-control-based-on-fuzzy-reinforcement-learning-for-minimally-invasive-surgery-manipulator
#13
Zhijiang Du, Wei Wang, Zhiyuan Yan, Wei Dong, Weidong Wang
In order to get natural and intuitive physical interaction in the pose adjustment of the minimally invasive surgery manipulator, a hybrid variable admittance model based on Fuzzy Sarsa(λ)-learning is proposed in this paper. The proposed model provides continuous variable virtual damping to the admittance controller to respond to human intentions, and it effectively enhances the comfort level during the task execution by modifying the generated virtual damping dynamically. A fuzzy partition defined over the state space is used to capture the characteristics of the operator in physical human-robot interaction...
April 12, 2017: Sensors
https://www.readbyqxmd.com/read/28416838/-clinical-research-on-robot-assisted-percutaneous-pelvic-and-acetabular-screws-surgery
#14
C P Zhao, J Q Wang, Y G Su, W Han, L Zhou, M Y Wang
OBJECTIVE: To evaluate the security and efficiency of a surgical robotic assisted percutaneous screw fixation for the treatment of pelvic and acetabular fractures. METHODS: In the study, 12 patients with pelvic and acetabular fractures who were treated in Beijing Jishuitan Hospital from January to April in 2016 were involved in this research. The research subjects were randomly divided into two groups: the experimental group and the control group. Robotic-assisted percutaneous sacroiliac screw internal fixations were performed under the guidance of fluoroscopy navigation in the experimental group; in the control group, doctors operated manually guided by fluoroscopy...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28412954/does-a-quality-improvement-campaign-accelerate-take-up-of-new-evidence-a-ten-state-cluster-randomized-controlled-trial-of-the-institute-for-health-improvement-s-project-joints
#15
Eric C Schneider, Melony E Sorbero, Ann Haas, M Susan Ridgely, Dmitry Khodyakov, Claude M Setodji, Gareth Parry, Susan S Huang, Deborah S Yokoe, Don Goldmann
BACKGROUND: A decade ago, the Institute for Healthcare Improvement pioneered a quality improvement (QI) campaign, leveraging organizational and personal social networks to disseminate new practices. There have been few rigorous studies of the QI campaign approach. METHODS: Project JOINTS (Joining Organizations IN Tackling SSIs) engaged a network of state-based organizations and professionals in a 6-month QI campaign promoting adherence to three new evidence-based practices known to reduce the risk of infection after joint replacement...
April 17, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28411552/reliability-of-four-models-for-clinical-gait-analysis
#16
Hans Kainz, David Graham, Julie Edwards, Henry P J Walsh, Sheanna Maine, Roslyn N Boyd, David G Lloyd, Luca Modenese, Christopher P Carty
Three-dimensional gait analysis (3DGA) has become a common clinical tool for treatment planning in children with cerebral palsy (CP). Many clinical gait laboratories use the conventional gait analysis model (e.g. Plug-in-Gait model), which uses Direct Kinematics (DK) for joint kinematic calculations, whereas, musculoskeletal models, mainly used for research, use Inverse Kinematics (IK). Musculoskeletal IK models have the advantage of enabling additional analyses which might improve the clinical decision-making in children with CP...
April 3, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28411488/inter-joint-coordination-of-posture-on-a-seesaw-device
#17
Frédéric Noé, Xavier García-Massó, Thierry Paillard
Even though specific adjustments of the multi-joint control of posture have been observed when posture is challenged, multi-joint coordination on a seesaw device has never been accurately assessed. The current study was conducted in order to investigate the multi-joint coordination when subjects were standing on either a seesaw device or on a stable surface, with the eyes open or closed. Eighteen healthy active subjects were recruited. A principal component analysis and a Self-Organizing Maps analysis were performed on the joint angles in order to detect and characterize dominant coordination patterns...
April 8, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28410971/the-association-between-parity-and-inflammation-among-mexican-american-women-of-reproductive-age-varies-by-acculturation-level-results-of-the-national-health-and-nutrition-examination-survey-1999-2006
#18
Natalya Rosenberg, Martha L Daviglus, Holli A DeVon, Chang Gi Park, Kamal Eldeirawi
INTRODUCTION: Parity and acculturation are linked with cardiometabolic risk. Their joint association with cardiometabolic health among Mexican-American women is less established, even though immigrant Mexican-American women have the highest fertility rate in the United States. We examined the modifying role of acculturation on the association of parity with a cardiometabolic risk biomarker, C-reactive protein (CRP). METHODS: Participants (n = 1,002) were women of Mexican background, ages 16 to 39 years, in the National Health and Nutrition Examination Survey (NHANES) from 1999 through 2006...
April 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28409100/arthroscopic-technique-for-treatment-of-schatzker-type-iii-tibia-plateau-fractures-without-fluoroscopy
#19
Afsar T Ozkut, Oguz S Poyanli, Ersin Ercin, Kaya Akan, Irfan Esenkaya
Accurate reduction and maintenance of the stability with correct implant positioning is critical for surgical treatment of tibial plateau fractures. Our technique includes an arthroscopic reduction and fixation of Schatzker type III tibial plateau fractures with a bulls-eye screw placement without fluoroscopy control. With the arthroscopic guidance, an anterior cruciate ligament drill guide is placed and a K-wire sent to the midpoint of the depressed fragment through the guide at a 40° angle to the coronal axis of the tibia...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28405377/modulation-of-leg-joint-function-to-produce-emulated-acceleration-during-walking-and-running-in-humans
#20
Dominic James Farris, Brent J Raiteri
Understanding how humans adapt gait mechanics for a wide variety of locomotor tasks is important for inspiring the design of robotic, prosthetic and wearable assistive devices. We aimed to elicit the mechanical adjustments made to leg joint functions that are required to generate accelerative walking and running, using metrics with direct relevance to device design. Twelve healthy male participants completed constant speed (CS) walking and running and emulated acceleration (ACC) trials on an instrumented treadmill...
March 2017: Royal Society Open Science
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