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JOURNAL ARTICLE
Arshad Islam, Bruno Rodrigues do Prado, Dalton Dittz, Bernardo Lages Rodrigues, Sydnei Magno da Silva, Rubens L do Monte-Neto, Muhammad Shabeer, Frédéric Frézard, Cynthia Demicheli
The aim the present study was to investigate the impact of novel pentavalent organobismuth and organoantimony complexes on membrane integrity and their interaction with DNA, activity against Sb(III)-sensitive and -resistant Leishmania strains and toxicity in mammalian peritoneal macrophages. Ph3 M(L)2 type complexes were synthesized, where M = Sb(V) or Bi(V) and L = deprotonated 3-(dimethylamino)benzoic acid or 2-acetylbenzoic acid. Both organobismuth(V) and organoantimony(V) complexes exhibited efficacy at micromolar concentrations against Leishmania amazonensis and L...
May 2024: Drug Development Research
#22
JOURNAL ARTICLE
Neelam Bodhale, Saptaparnee Saha, Dhiraj Gurjar, Nicolas Grandchamp, Arup Sarkar, Bhaskar Saha
Leishmaniasis, a major globally re-emerging neglected tropical disease, has a restricted repertoire of chemotherapeutic options due to a narrow therapeutic index, drug resistance, or patient non-compliance due to toxicity. The disease is caused by the parasite Leishmania that resides in two different forms in two different environments: as sessile intracellular amastigotes within mammalian macrophages and as motile promastigotes in sandfly gut. As mitogen-activated protein kinases (MAPKs) play important roles in cellular differentiation and survival, we studied the expression of Leishmania donovani MAPKs (LdMAPKs)...
May 3, 2024: Cytokine
#23
JOURNAL ARTICLE
Diksha Kumari, Parampreet Kour, Chetan Paul Singh, Rinku Choudhary, Syed Mudassir Ali, Sagar Bhayye, Yogesh P Bharitkar, Kuljit Singh
Parthenium hysterophorus plant has a diverse chemical profile and immense bioactive potential. It exhibits excellent pharmacological properties such as anti-cancer, anti-inflammatory, anti-malarial, microbicidal, and anti-trypanosomal. The present study aims to evaluate the anti-leishmanial potential and toxicological safety of anhydroparthenin isolated from P. hysterophorus. Anydroparthenin was extracted from the leaves of P. hysterophorus and characterized through detailed analysis of 1 H, 13 C NMR, and HRMS...
May 1, 2024: International Journal of Biological Macromolecules
#24
REVIEW
Julia Walter-Weingärtner, Michèle Bergmann, Katrin Hartmann
For detection of infectious diseases, several point-of-care (POC) tests are on the market in addition to methods performed in commercial laboratories. These POC tests are based on enzyme-linked immunosorbent assay (ELISA) or other immunochromatographic technologies and present results within few minutes in veterinary practice. This article gives an overview of the utility of numerous POC tests of different manufacturers for detection of parvovirus antigen in feces, Dirofilaria (D.) immitis antigen in blood as well as antibodies against Borrelia ( B ...
April 2024: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
#25
JOURNAL ARTICLE
Luciana Polaco Covre, Carlos Henrique Fantecelle, Ariadne Mendes Queiroz, Julia Miranda Fardin, Pedro Henrique Miranda, Sian Henson, Alessandra Marcia da Fonseca-Martins, Herbert Leonel de Matos Guedes, David Mosser, Aloisio Falqueto, Arne Akbar, Daniel Claudio Oliveira Gomes
Natural killer (NK) cells include different subsets with diverse effector capacities that are poorly understood in the context of parasitic diseases. Here, we investigated inhibitory and activating receptor expression on NK cells in patients with cutaneous leishmaniasis (CL) and explored their phenotypic and functional heterogeneity based on CD57 and NKG2C expression. The expression of CD57 identified NK cells that accumulated in CL patients and exhibited features of senescence. The CD57+ cells exhibited heightened levels of the activating receptor NKG2C and diminished expression of the inhibitory receptor NKG2A...
May 3, 2024: Clinical and Experimental Immunology
#26
JOURNAL ARTICLE
Joaquina Martín-Sánchez, Victoriano Díaz-Sáez, Francisco Morillas-Márquez, Victoriano Corpas-López, Patricia Ibáñez-De Haro, Andrés Torres-Llamas, Manuel Morales-Yuste
OBJECTIVE: We contribute to the understanding of the transmission dynamics of Leishmania infantum suggesting the involvement of rabbits as wild reservoirs. RESULTS: The prevalence of infection was 86.0% (270/314 wild rabbits) ranging from 18.2% to 100% in natural geographical regions. The estimated average parasite load was 324.8 [CI 95% 95.3-554.3] parasites per mg of ear lobe ranging from 0 to 91,597 parasites/mg per tissue section. CONCLUSIONS: A positive correlation was found between skin parasite load in wild rabbits and human incidence with evidence of the presence of the same L...
May 1, 2024: Zoonoses and Public Health
#27
REVIEW
Filipe Dantas-Torres
Canine leishmaniasis is a widespread disease on the American continent, with cases reported from Uruguay to the USA and Canada. While numerous Leishmania spp. have been reported in dogs in this region, Leishmania infantum and Leishmania braziliensis are the most common etiological agents of canine leishmaniasis from a continental perspective. Nonetheless, other species may predominate locally in some countries. The participation of dogs in the transmission cycle of various Leishmania spp. has long been speculated, but evidence indicates that their role as reservoirs of species other than L...
April 30, 2024: Parasites & Vectors
#28
JOURNAL ARTICLE
Naianda Rezende Ribeiro, Lucas Magno Oliveira Santos, Scarleth Silva Costa, Carolina Kei Myasaki, Daniela Pagliara Lage, Vivian Tamietti Martins, Rory Cristiane Fortes De Brito, Larissa Chaves Freire, Ana Maria Ravena Severino Carvalho, Bryan Victor Serafim Brigido, Ricardo José Alves, Eduardo Antonio Ferraz Coelho, Bruno Mendes Roatt, Daniel Menezes-Souza, Mariana Costa Duarte
In the context of neglected diseases, tegumentary leishmaniasis (TL) presents an emerging and re-emerging character in the national territory and in the world. The treatment of TL has limitations, such as intravenous administration route, high toxicity, and high treatment costs. Thus, several researchers work on new therapeutic strategies to improve the effectiveness of the treatment of leishmaniasis. In this light, the present study used a topical formulation, containing 8-hydroquinoline (8-HQN), for the treatment of Balb/c mice infected with L...
April 26, 2024: European Journal of Pharmaceutics and Biopharmaceutics
#29
JOURNAL ARTICLE
Guilherme Freitas de Lima Hercos, Mariza Gabriela Faleiro de Moura Lodi Cruz, Ana Clara Cassiano Martinho, Daniela de Melo Resende, Danilo Farago Nascimento, Paula Derksen Macruz, Eduardo Jorge Pilau, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior
Leishmaniasis and Chagas disease are neglected tropical diseases caused by Trypanosomatidae parasites. Given the numerous limitations associated with current treatments, such as extended treatment duration, variable efficacy, and severe side effects, there is an urgent imperative to explore novel therapeutic options. This study details the early stages of hit-to-lead optimization for a benzenesulfonyl derivative, denoted as initial hit, against Trypanossoma cruzi (T. cruzi), Leishmania infantum (L. infantum) and Leishmania braziliensis (L...
April 24, 2024: Bioorganic & Medicinal Chemistry
#30
JOURNAL ARTICLE
Trong-Nhat Phan, Kyu-Ho Paul Park, David Shum, Joo Hwan No
Leishmaniasis, an infectious disease caused by pathogenic Leishmania parasites, affects millions of people in developing countries, and its re-emergence in developed countries, particularly in Europe, poses a growing public health concern. The limitations of current treatments and the absence of effective vaccines necessitate the development of novel therapeutics. In this study, we focused on identifying small molecule inhibitors which prevents the interaction between peroxin 5 (PEX5) and peroxisomal targeting signal 1 (PTS1), pivotal for kinetoplastid parasite survival...
April 17, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#31
JOURNAL ARTICLE
Imen Abid, Wassim Moslah, Sandrine Cojean, Nicolas Imbert, Philippe M Loiseau, Alain Chamayou, Najet Srairi-Abid, Rachel Calvet, Michel Baltas
Chalcones are polyphenols that belong to the flavonoids family, known for their broad pharmacological properties. They have thus attracted the attention of chemists for their obtention and potential activities. In our study, a library of compounds from 2'-hydroxychalcone's family was first synthesized. A one-step mechanochemical synthesis via Claisen-Schmidt condensation reaction under ball mill conditions was studied, first in a model reaction between a 5'-fluoro-2'-hydroxyacetophenone and 3,4-dimethoxybenzaldehyde...
April 17, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#32
JOURNAL ARTICLE
Raphaela Ariany Silva, Danielle Soter Damasio, Larissa Dutra Coelho, Eliane de Morais-Teixeira, Celso M Queiroz-Junior, Paulo Eduardo Souza, Ricardo Bentes Azevedo, Antônio Tedesco, Lucas Antônio Ferreira, Mônica Cristina Oliveira, Marta Gontijo Aguiar
Cutaneous leishmaniasis (CL) is a neglected tropical disease. The treatment is restricted to drugs, such as meglumine antimoniate and amphotericin B, that exhibit toxic effects, high cost, long-term treatment, and limited efficacy. The development of new alternative therapies, including the identification of effective drugs for the topical and oral treatment of CL, is of great interest. In this sense, a combination of topical photodynamic therapy (PDT) with chloroaluminum phthalocyanine liposomes (Lip-ClAlPc) and the oral administration of a self-emulsifying drug delivery system containing fexinidazole (SEDDS-FEX) emerges as a new strategy...
April 7, 2024: Pharmaceutics
#33
JOURNAL ARTICLE
Alice P Borges, Malu M S Obata, Silvia H Libardi, Rafael O Trevisan, Victor M Deflon, Ulrich Abram, Francis B Ferreira, Luiz Antônio S Costa, Antonio O T Patrocínio, Marcos V da Silva, Júlio C Borges, Pedro I S Maia
Leishmaniasis is a group of parasitic diseases with the potential to infect more than 1 billion people; however, its treatment is still old and inadequate. In order to contribute to changing this view, this work consisted of the development of complexes derived from MI metal ions with thioureas, aiming to obtain potential leishmanicidal agents. The thiourea ligands (HLR ) were obtained by reactions of p -toluenesulfohydrazide with R-isothiocyanates and were used in complexation reactions with AgI and AuI , leading to the formation of complexes of composition [M(HLR )2 ]X (M = Ag or Au; X = NO3 - or Cl- )...
March 25, 2024: Pharmaceutics
#34
REVIEW
Eileen Uribe-Querol, Carlos Rosales
Neutrophils are the most abundant polymorphonuclear granular leukocytes in human blood and are an essential part of the innate immune system. Neutrophils are efficient cells that eliminate pathogenic bacteria and fungi, but their role in dealing with protozoan parasitic infections remains controversial. At sites of protozoan parasite infections, a large number of infiltrating neutrophils is observed, suggesting that neutrophils are important cells for controlling the infection. Yet, in most cases, there is also a strong inflammatory response that can provoke tissue damage...
April 19, 2024: Microorganisms
#35
JOURNAL ARTICLE
Rafael Rocha, Cláudia Conceição, Luzia Gonçalves, Ana Cláudia Carvalho, André Maia, André Martins, António Carujo, António Maio, Catarina Forra, Catarina Melita, Daniela Couto, Diana Fernandes, Dulce Pereira, Ema Leal, Helena Sarmento, Inês Sousa, Jean-Pierre Gonçalves, Joana Marinho, Joana Vasconcelos, João Cunha, João Rodrigues, José Miguel Silva, Lídia Caley, Luís Malheiro, Luís Santos, Margarida Garcia, Maria Cunha, Maria Lima, Maria Margarida Andrade, Marta Marques, Miguel Alpalhão, Mónica Silva, Rita Ferraz, Rui Soares, Salomão Fernandes, Samuel Llobet, Sofia Cruz, Teresa Guimarães, Tiago Branco, Tomás Robalo-Nunes, Vasco Almeida, Carla Maia
Leishmania infantum , a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Health System. Cases were screened through a search of diagnostic discharge codes or positive laboratory results for Leishmania infection...
April 18, 2024: Microorganisms
#36
JOURNAL ARTICLE
Yetsenia Del Valle Sánchez Uzcátegui, Fernando Tobias Silveira, Thais Gouvea de Morais, Rodrigo Ribeiro Furtado, Thiago Vasconcelos Dos Santos, Marinete Marins Póvoa
The present work assessed the experimental susceptibility of Nyssomyia antunesi and Lutzomyia longipalpis to Leishmania ( Viannia ) lainsoni and L. ( V .) lindenbergi . A L. ( Leishmania ) chagasi - Lu. longipalpis combination was used as a susceptible control. Wild-caught Ny. antunesi and laboratory-bred Lu. longipalpis were membrane-fed on blood with a 5 × 106 /mL log-phase promastigote culture suspension and dissected on days 2 and 8 post-blood meal (pbm) for analysis focused on the assessment of parasitoses, as well as placement and promastigote morphotyping...
April 17, 2024: Microorganisms
#37
REVIEW
Gustavo Benaim, Alberto Paniz-Mondolfi
Originally developed as a chemotherapeutic agent, miltefosine (hexadecylphosphocholine) is an inhibitor of phosphatidylcholine synthesis with proven antiparasitic effects. It is the only oral drug approved for the treatment of Leishmaniasis and American Trypanosomiasis (Chagas disease). Although its precise mechanisms are not yet fully understood, miltefosine exhibits broad-spectrum anti-parasitic effects primarily by disrupting the intracellular Ca2+ homeostasis of the parasites while sparing the human hosts...
March 27, 2024: Biomolecules
#38
REVIEW
Isha Saini, Jyoti Joshi, Sukhbir Kaur
Infectious diseases like leishmaniasis, malaria, HIV, tuberculosis, leprosy and filariasis are responsible for an immense burden on public health systems. Among these, leishmaniasis is under the category I diseases as it is selected by WHO (World Health Organization) on the ground of diversity and complexity. High cost, resistance and toxic effects of Leishmania traditional drugs entail identification and development of therapeutic alternative. Since the natural infection elicits robust immunity, consistence efforts are going on to develop a successful vaccine...
April 23, 2024: Cellular Immunology
#39
JOURNAL ARTICLE
Lucas G Azevedo, Ezequiel Sosa, Artur T L de Queiroz, Aldina Barral, Richard J Wheeler, Marisa F Nicolás, Leonardo P Farias, Dario Fernández Do Porto, Pablo Ivan P Ramos
Leishmaniasis, a vector-borne disease, is caused by the infection of Leishmania spp., obligate intracellular protozoan parasites. Presently, human vaccines are unavailable, and the primary treatment relies heavily on systemic drugs, often presenting with suboptimal formulations and substantial toxicity, making new drugs a high priority for LMIC countries burdened by the disease, but a low priority in the agenda of most pharmaceutical companies due to unattractive profit margins. New ways to accelerate the discovery of new, or the repositioning of existing drugs, are needed...
April 16, 2024: International Journal for Parasitology, Drugs and Drug Resistance
#40
REVIEW
Sara Rossi, Valeria Tudino, Gabriele Carullo, Stefania Butini, Giuseppe Campiani, Sandra Gemma
The term "zoonosis" denotes diseases transmissible among vertebrate animals and humans. These diseases constitute a significant public health challenge, comprising 61% of human pathogens and causing an estimated 2.7 million deaths annually. Zoonoses not only affect human health but also impact animal welfare and economic stability, particularly in low- and middle-income nations. Leishmaniasis and schistosomiasis are two important neglected tropical diseases with a high prevalence in tropical and subtropical areas, imposing significant burdens on affected regions...
April 26, 2024: ACS Infectious Diseases
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