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Mathilde Guibert, Adeline Gasser, Hervé Kempf, Arnaud Bianchi
OBJECTIVES: Fibroblast Growth Factor 23 (FGF23) is well documented as a crucial player in the systemic regulation of phosphate homeostasis. Moreover, loss-of-function experiments have revealed that FGF23 also has a phosphate-independent and local impact on skeletogenesis. Here, we used ATDC5 cell line to investigate the expression of FGF23 and the role it may play locally during the differentiation of these cells. METHODS: ATDC5 cells were differentiated in the presence of insulin, and treated with recombinant FGF23 (rFGF23), inorganic phosphate (Pi) and/or PD173074, an inhibitor of FGF receptors (FGFRs)...
2017: PloS One
Ashley Chin, Jeffrey S Healey, Carlos S Ribas, Girish M Nair
Defibrillation testing is no longer routinely performed after automatic implantable cardioverter-defibrillator (AICD) implantation. However, certain subjects undergoing AICD implantation may be at higher risk of undersensing of ventricular arrhythmias resulting in potentially fatal outcomes. We present the case of a 30-year-old woman with hypertrophic cardiomyopathy (HCM; 'asymmetric septal hypertophy' morphologic variant) and prophylactic AICD who experienced an out of hospital cardiac arrest. AICD interrogation revealed undersensing as a result of intermittent high amplitude electrograms during an episode of ventricular fibrillation (VF)...
March 2015: Indian Pacing and Electrophysiology Journal
Efstathios T Detorakis, George Kymionis, Michael Tsatsos, Demetrios A Spandidos
In the present study, we aimed to evaluate the co-existence of ophthalmic pterygium with other ocular surface lesions in a cohort of patients from the Cretan population. This is a retrospective evaluation of all pterygia in patients examined and treated at the Department of Ophthalmology of the University Hospital of Heraklion, Greece during an 8-year period (from June 2006 to June 2014). A total of 158 cases was examined. Ocular surface images and medical history were evaluated in order to detect concomitant ocular surface pathological conditions...
January 2016: Experimental and Therapeutic Medicine
Bekir Serhat Yildiz, Murat Bilgin, Yusuf Izzettin Alihanoglu, Harun Evrengul
A coronary artery fistula consists of a communication between a coronary artery and a cardiac chamber, a great artery or the vena cava. It is the most common congenital anomaly that can affect coronary perfusion. However, coronary fistulas to one of the cardiac chambers and coexisting apical myocardial hypertophy are infrequent anomalies, and usually are found unexpectedly. Herein, we report a case in which all three major coronary arteries emptied into the left ventricle with apical hypertrophy, through multiple microfistulas...
July 2013: Journal of the Saudi Heart Association
Ioannis Angomachalelis, George Kyriazis, Nestor Angomachalelis
SESSION TYPE: ILD PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: :Nearly 21% of pulmonary and/or systemic Sarcoidosis (S) patients (pts) appeared developing pericardial involvement in their initial Hospital admission.This study investigates evaluation of the total ,multi stage,pericardial effusion frequency (P.Ef),not well established and reported in the literature.METHODS: 178/278 biopsy-proven ,pulmonary and/or systemic Sarcoidosis Pts,56 males and 122 females,mean age 47,8 yrs,were free of other clinical cardiovascular pathology and investigated for the possible development of the multi-stage,symptomatic or latent,pericardial granulomatosis...
October 1, 2012: Chest
Marko Spasić, Dragce Radovanović, Dragan Canović, Goran Azanjac, Predrag Djurdjević, Slobodanka Mitrović
INTRODUCTION: Klippel-Trenaunay syndrome (KTS) is a very rare congenital anomaly of blood vessels, characterized by the following clinical triad: varicose superficial veins, port-wine stain and usually bony and soft tissue hypertophy of extremities, most often located in the lower extremities. It is often accompanied by visceral manifestations, and rarely combined with splenomegaly. CASE OUTLINE: A 30-year-old female patient came to the Surgery Clinic because of occasional left hypochondrial pain...
November 2012: Srpski Arhiv za Celokupno Lekarstvo
Fabrisia Ambrosio, G Kelley Fitzgerald, Ricardo Ferrari, Giovanna Distefano, George Carvell
Neuromuscular electrical stimulation (NMES) is a common clinical modality that is widely used to restore (1), maintain (2) or enhance (3-5) muscle functional capacity. Transcutaneous surface stimulation of skeletal muscle involves a current flow between a cathode and an anode, thereby inducing excitement of the motor unit and the surrounding muscle fibers. NMES is an attractive modality to evaluate skeletal muscle adaptive responses for several reasons. First, it provides a reproducible experimental model in which physiological adaptations, such as myofiber hypertophy and muscle strengthening (6), angiogenesis (7-9), growth factor secretion (9-11), and muscle precursor cell activation (12) are well documented...
2012: Journal of Visualized Experiments: JoVE
Marielle Doyon, Taben Mary Hale, Julie-Emilie Huot-Marchand, Rong Wu, Jacques de Champlain, Denis DeBlois
It has been reported that HMG-CoA reductase inhibitors such as atorvastatin induce vascular smooth muscle cell (SMC) apoptosis in vitro. However, this effect remains to be demonstrated in vivo. The present studies were designed to test the ability of atorvastatin to induce SMC apoptosis in vivo, using the spontaneously hypertensive rat (SHR) as a well-known reference model of SMC apoptosis induction in vivo by cardiovascular drugs including the calcium channel blocker amlodipine. Atorvastatin was administered to SHR for 3 or 6 weeks either alone or together with amlodipine, a drug combination clinically available to patients...
January 2011: Vascular Pharmacology
Lukasz A Małek, Lidia Chojnowska, Mateusz Spiewak, Mariusz Kłopotowski, Jolanta Miśko, Joanna Petryka, Barbara Miłosz, Witold Ruzyłło
Fabry's disease (FD) is a rare hereditary disorder caused by the loss of alpha galactosidase A activity leading to accumulation of glycosphingolipids in various organs including hypertrophy of the heart. Most reports on cardiac involvement in FD focus on the left ventricular hypertrophy (LVH) and its relation to diastolic function. However, recent studies demonstrated large subset of patients with FD and right ventricle (RV) hypertophy. The accurate depiction of RV volumes, function and mass is possible with cardiovascular magnetic resonance (CMR)...
August 2010: Kardiologia Polska
Dejan Rasić, Aleksandar Perić, Biserka Vukomanović-Durdević
The purpose of this report was to present an unusual case of an unilateral tonsillar hypertophy caused by actinomycosis. It is an infrequent bacterial infection nowadays. Only five such cases have been reported up to now. Diagnosis is difficult, because there are not specific diagnostic procedures. Medical treatment consists of surgical excision of tonsils and postoperative antibiotic therapy.
2010: Acta Medica (Hradec Králové)
Athanasios G Kaditis, Efthimia Kalampouka, Souzana Hatzinikolaou, Loukia Lianou, Maria Papaefthimiou, Polytimi Gartagani-Panagiotopoulou, Elias Zintzaras, George Chrousos
BACKGROUND: Reports in adults and children have correlated history of wheezing or asthma with the presence of obstructive sleep-disordered breathing but the mechanism of this epidemiologic association is unknown. The goal of the present study was to examine whether tonsillar hypertophy can explain this association. METHODS: Children were recruited from the Emergency Department and the Pediatric Pulmonology Clinic. History of wheezing requiring treatment (explanatory variable) and snoring > or = 1 night/week (outcome) were recorded and presence of tonsillar hypertrophy (outcome) was assessed...
March 2010: Pediatric Pulmonology
Carole Rosenberg, Stéphanie Arrestier, Fabien Etchepare, Bruno Fautrel, Sylvie Rozenberg, Pierre Bourgeois
OBJECTIVE: To describe echographic abnormalities on the proximal (PIP) and distal (DIP) interphalangeal joints of healthy subjects. METHODS: Healthy asymptomatic volunteers under forty were enrolled. Ultrasonography was performed on PIP and DIP 2-5 in the presence of two operators. In B mode, synovial hypertophy and effusion were defined with the OMERACT criteria. In power Doppler mode, the inflammatory activity was evaluated. RESULTS: 46 subjects were enrolled: mean age 25...
May 2009: Joint, Bone, Spine: Revue du Rhumatisme
L A Begley, S Kasina, J MacDonald, J A Macoska
Benign Prostatic Hypertrophy (BPH, also known as benign prostatic hyperplasia or benign prostatic enlargement), is one of the most common benign proliferative conditions associated with aging in men and is pathologically characterized by the proliferation of fibroblast/myofibroblast and epithelial cell types in the prostate. Previous studies from our laboratory have shown that the CXC-type chemokines, CXCL5 and CXCL12, are secreted by aging prostate stroma and promote both proliferative and transcriptional responses from prostate epithelial cells...
August 2008: Cytokine
B Pereira, O Morel, C Blondet, L Grunebaum, B Goichot, N Merrien, L Jesel, A Faure, A Trinh, S Vinzio, A Constantinesco, P Bareiss
BACKGROUND: Accelerated atherothrombosis is a common feature in diabetes mellitus patients (DM), which can be related to abnormalities in vascular cell apoptosis and activation leading to the release of procoagulant microparticles (MPs). In DM patients, we hypothesized that circulating levels of biomarkers involved in atherothrombosis processes as well as cardiac and carotid echocardiography variables could be useful in the detection of silent myocardial diagnosed by myocardial perfusion imaging...
August 2008: Annales de Cardiologie et D'angéiologie
Fausto Bogazzi, Massimo Lombardi, Elisabetta Strata, Giovanni Aquaro, Vitantonio Di Bello, Chiara Cosci, Chiara Sardella, Enrica Talini, Enio Martino
OBJECTIVE: Left ventricular (LV) hypertrophy and myocardial fibrosis are considered the main pathological features of acromegalic cardiomyopathy. The aim of the study was to evaluate the proportion of LV hypertrophy and the presence of fibrosis in acromegalic cardiomyopathy in vivo using cardiac magnetic resonance (CMR). DESIGN AND PATIENTS: Fourteen consecutive patients (eight women, mean age 46 +/- 10 years) with untreated active acromegaly were submitted to two-dimensional (2D) colour Doppler and integrated backscatter (IBS) echocardiography and CMR...
March 2008: Clinical Endocrinology
Bruce M Carlson
This article presents some general principles underlying regenerative phenomena in vertebrates, starting with the epimorphic regeneration of the amphibian limb and continuing with tissue and organ regeneration in mammals. Epimorphic regeneration following limb amputation involves wound healing, followed shortly by a phase of dedifferentiation that leads to the formation of a regeneration blastema. Up to the point of blastema formation, dedifferentiation is guided by unique regenerative pathways, but the overall developmental controls underlying limb formation from the blastema generally recapitulate those of embryonic limb development...
November 2005: Anatomical Record. Part B, the New Anatomist
Beata Zielnik-Jurkiewicz, Magdalena Rakowska
Hypertophy of pharyngeal tonsil and palatine tonsils is the most common cause of nasal obstruction in children. When the obstruction of the nasopharynx causes recurrent infections of upper respiratory tract, chronic otitis media secretoria or sleep apnoea, then adenoidectomy with or without tonsillectomy is indicated. The purpose of the study was analysis of postoperative hemorrhage after adenoidectomy with or without tonsillectomy. The influent of frequent infections of upper respiratory tract, disorders of blood clotting, chronic diseases, seasons of the year, operation time and general anesthesia on postoperative hemorrhage was estimated...
2005: Otolaryngologia Polska
Kazuko Itoh, Motoko Tanaka, Kazutaka Matsushita, Nobuhiro Miyamura, Kenroh Nishida, Eiichi Araki, Hiroshi Nonoguchi, Kimio Tomita
Fabry disease is an X-linked recessive disease resulting from a deficiency of the lysosomal hydrolase alpha-galactosidase A. In male patients with the classic hemizygous form, acroparesthesias, hypohidrosis, corneal opacities, and dysfunction of the heart, brain, and kidney are observed. Recently, it was reported that 0.5-1.2% of male chronic hemodialysis (HD) patients were diagnosed as having Fabry disease based on the measurement of alpha-galactosidase A activity. Fabry disease is thought to be an important cause of end-stage renal disease...
2005: Nihon Jinzo Gakkai Shi
C Pellnitz, C Geier, A Perrot, R Dietz, K J Osterziel, W Haverkamp
Hypertrophic cardiomyopathy (HCM) is a relatively frequent, genetically determined primary cardiomyopathy, characterized by most often asymmetric hypertrophy of the ventricular septum with or without systolic obstruction of the left ventricular outflow tract. HCM is a genetically heterogeneous disease, with 12 different disease-causing genes beeing indentified to date. Histologically the disease is characterized by hypertophy and disarray of myofibrils as well as by an increase in myocardial fibrosis. Clinically, these changes may lead to palpitations, dyspnoe on exertion, and/or angina pectoris...
May 6, 2005: Deutsche Medizinische Wochenschrift
Senija Rasić, Indira Kulenović, Azra Haracić, Amra Catović
UNLABELLED: Cardiovascular diseases are the major cause of mortality in uraemic patients treated by hemodialysis. Left ventricular hypertrophy (LVH) is considered to be a major cardiac risk factor. AIM: To investigate the presence of some potential adverse risk factors in hemodialysis patients with developed LVH echocardiography verified and determine their relative contribution to the LVH in comparison with patients with normal LV. METHOD: The study included 50 patients with end-stage renal disease in the first 2 years of hemodialysis treatment, who were followed up during one year...
February 2004: Bosnian Journal of Basic Medical Sciences
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