keyword
https://read.qxmd.com/read/38525111/dickkopf-1-drives-perineural-invasion-via-pi3k-akt-signaling-pathway-in-head-and-neck-squamous-cancer
#1
JOURNAL ARTICLE
Jingyi Wang, Qianying Li, Faya Liang, Xin Du, Pan Song, Taowei Wu, Renhui Chen, Xiaorong Lin, Qinglian Liu, Hai Hu, Ping Han, Xiaoming Huang
Perineural invasion (PNI) leads to the poor prognosis of head and neck squamous cancer (HNSCC) patients, but the mechanism of PNI remains unclear. Dickkopf-1 (DKK1), a secretory protein in the Wnt signaling pathway, was found indeed upregulated in HNSCC cells and tissues. Higher expression of DKK1 was statistically relevant to T stage, N stage, PNI, and poor prognosis of HNSCC. DKK1 overexpression enhanced the migration abilities of cancer cells. Moreover, DKK1-overexpressing cancer cells promoted cancer cells invasion of peripheral nerves in vitro and in vivo...
April 2024: MedComm
https://read.qxmd.com/read/38514441/first-report-of-expansion-of-virulence-in-puccinia-striiformis-f-sp-tritici-to-wheat-resistance-genes-yr10-and-yr24-in-the-middle-east
#2
JOURNAL ARTICLE
Kumarse Nazari, Ezgi Kurtulus, Handan Kavaz, Rola El Amil, Tina Thach, Hakan Hekiman, Gurkan Basbagci, Emine Burcu Turgay, Doaa R El-Naggar, Walid El-Orabey, Reda I Omara, Kholoud M Alananbeh, Ayed Al-Abdallat, Monther M Tahat, Khaled Heimoun, Ghias Mhairy, Samer Abau Ghorrah
Over the last decade, field assessments of the yellow rust differential lines for resistance genes Yr10 and Yr24 and race analysis in the Middle East have demonstrated efficient yellow rust control by Yr10 and Yr24 (=Yr26). Yellow rust samples collected during 2018-21 in Central West Asia & North and sub-Saharan Africa underwent race analysis at the Regional Cereal Rust Research Center in Izmir, Türkiye. The infected leaf segments were subjected to rehydration at 20°C for three hours. Subsequently, the leaf segments were rubbed on the first leaves of seedlings of susceptible cultivar Morocco...
March 21, 2024: Plant Disease
https://read.qxmd.com/read/38499638/close-negative-correlation-of-local-and-circulating-dickkopf-1-and-sclerostin-levels-during-human-fracture-healing
#3
JOURNAL ARTICLE
Julia Starlinger, Jonas Santol, Georg Kaiser, Kambiz Sarahrudi
Wnt signaling is critically involved in fracture healing. Existing data predominantly relies on rodent models. Here, we explored local and circulating Dickkopf-1 (DKK1) levels in patients with respect to fracture healing and explore its association to sclerostin (SOST). 69 patients after surgical stabilization of long bone fractures of which six patients had impaired fracture healing were included in this study. Life-style and patient related factors with a known effect on DKK1 and SOST were recorded. DKK1 and SOST concentrations were measured using enzyme-linked immunosorbent assay (ELISA) at the fracture site and in circulation...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38476861/prognostic-biomarkers-and-aki-potential-to-enhance-the-identification-of-post-operative-patients-at-risk-of-loss-of-renal-function
#4
REVIEW
Rishabh Singh, James C Watchorn, Alexander Zarbock, Lui G Forni
Acute kidney injury (AKI) is a common complication after surgery and the more complex the surgery, the greater the risk. During surgery, patients are exposed to a combination of factors all of which are associated with the development of AKI. These include hypotension and hypovolaemia, sepsis, systemic inflammation, the use of nephrotoxic agents, tissue injury, the infusion of blood or blood products, ischaemia, oxidative stress and reperfusion injury. Given the risks of AKI, it would seem logical to conclude that early identification of patients at risk of AKI would translate into benefit...
2024: Research and Reports in Urology
https://read.qxmd.com/read/38472351/current-and-developing-pharmacologic-agents-for-improving-skeletal-health-in-adults-with-osteogenesis-imperfecta
#5
REVIEW
Winnie Liu, Lindsey Nicol, Eric Orwoll
Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility largely caused by defects in structure, synthesis, or post-translational processing of type I collagen. Drugs currently used to improve skeletal health in OI were initially developed to treat osteoporosis and clinical trials are ongoing to study their effectiveness in OI adults. Additionally, novel bone-protective agents are in preclinical studies and various phases of OI clinical trials. This review summarizes current knowledge on available pharmacologic agents and current drug trials involving OI participants...
March 12, 2024: Calcified Tissue International
https://read.qxmd.com/read/38472135/association-of-urinary-dickkopf-3-levels-with-cardiovascular-events-and-kidney-disease-progression-in-systolic-blood-pressure-intervention-trial
#6
JOURNAL ARTICLE
Vanessa-Giselle Peschard, Rebecca Scherzer, Ronit Katz, Teresa K Chen, Alexander L Bullen, Kasey Campos, Michelle M Estrella, Joachim H Ix, Michael G Shlipak
BACKGROUND: Urinary Dickkopf-3 (uDKK3) is a tubular epithelial-derived profibrotic protein secreted into the urine under tubular stress. It is associated with kidney disease progression in persons with chronic kidney disease (CKD) and diabetes, and post-operative and contrast-associated acute kidney injury (AKI). We explored associations of uDKK3 with cardiovascular disease (CVD), kidney and mortality outcomes within the subset of Systolic Blood Pressure Intervention Trial (SPRINT) participants with non-diabetic CKD...
March 13, 2024: Kidney360
https://read.qxmd.com/read/38431439/acquired-curved-hair-is-caused-by-fusion-of-multiple-hair-matrix-cells
#7
JOURNAL ARTICLE
Ippei Horibe, Sara Izumi, Yuru Ke, Nanami Tanahashi, Yusuke Takagi, Ryoji Ishihara, Takaya Nakano, Takaaki Sumiyoshi, Yasuo Nagaoka
BACKGROUND: "Curved hair" caused by acquired factors is considered to have adverse cosmetic effects, but the detailed mechanism behind curved hair remains obscure. OBJECTIVE: We attempted to clarify the causes of curved hair that appeared to have occurred via acquired factors. METHODS: Outer root sheath cells (ORSC) isolated from plucked human hair follicles were used to evaluate the expression of type IV collagen. Straight and curved hairs with hair follicle tissue attached were also collected from the same individuals and subjected to morphological, immunohistochemical, and gene expression analyses...
February 12, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38401687/icbp90-an-epigenetic-regulator-induces-dkk3-promoter-methylation-promotes-glioma-progression-and-reduces-sensitivity-to-cis-platinum
#8
JOURNAL ARTICLE
Qinchen Cao, Xinxin Wang, Jie Liu, Yang Dong, Xiaolong Wu, Yin Mi, Ke Liu, Mingzhi Zhang, Yonggang Shi, Ruitai Fan
Glioma is the most common brain malignancy, characterized by high morbidity, high mortality, and treatment-resistance. Inverted CCAAT box Binding Protein of 90 kDa (ICBP90) has been reported to be involved in tumor progression and the maintenance of DNA methylation. Herein, we constructed ICBP90 over-expression and knockdown glioma cell lines, and found that ICBP90 knockdown inhibited glioma cell proliferation, migration, and invasion. ICBP90 silencing potentially enhanced cellular sensitivity to cis-platinum (DDP) and exacerbated DDP-induced pyroptosis, manifested by the elevated levels of gasdermin D-N-terminal and cleaved caspase 1; whereas, ICBP90 over-expression exhibited the opposite effects...
February 22, 2024: Experimental Cell Research
https://read.qxmd.com/read/38400523/icariin-ameliorates-glycolytic-dysfunction-in-alzheimer-s-disease-models-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway
#9
JOURNAL ARTICLE
Ju Liu, Ai-Hong Wei, Ting-Ting Liu, Xin-Hao Ji, Ying Zhang, Fei Yan, Mei-Xiang Chen, Jin-Bo Hu, Shao-Yu Zhou, Jing-Shan Shi, Hai Jin, Feng Jin
It was reported that the Wnt/β-catenin pathway is involved in the regulation of aerobic glycolysis and that brain glycolytic dysfunction results in the development of Alzheimer's disease (AD). Icariin (ICA), an active component extracted from Epimedii Folium, has been reported to produce neuroprotective effects in multiple models of AD, but its underlying mechanism remains to be fully described. We aimed to investigate the protective effects of ICA on animal and cell models of AD and confirm whether the Wnt/β-catenin pathway has functions in the neuroprotective function of ICA...
February 23, 2024: FEBS Journal
https://read.qxmd.com/read/38398550/-%C3%AE-nicotinamide-mononucleotide-promotes-cell-proliferation-and-hair-growth-by-reducing-oxidative-stress
#10
JOURNAL ARTICLE
Chuntao Xu, Jiawei Dai, Hongxia Ai, Weian Du, Hongbing Ji
β-Nicotinamide mononucleotide (NMN) has shown promising effects on intestinal health, and it is extensively applied as an anti-aging and Alzheimer's disease therapeutic, due to its medicinal properties. The effects of NMN on the growth of mouse hair were observed after hair removal. The results indicated that NMN can reverse the state of hair follicle atrophy, hair thinning, and hair sparsity induced by dihydrotestosterone (DHT), compared to that of minoxidil. In addition, the action mechanisms of NMN promoting hair growth in cultured human dermal papilla cells (HDPCs) treated with DHT were investigated in detail...
February 8, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38397048/deciphering-early-stage-molecular-mechanisms-of-negative-pressure-wound-therapy-in-a-murine-model
#11
JOURNAL ARTICLE
Yu-Chiau Shyu, Ting-Shuo Huang, Hua-Sheng Chiu, Pavel Sumazin, Xin-Yu Lin, Po-Cheng Liao, Cai-Cin Liou, Fang-Chia Hsu, Jyuan-Siou Lin, Chih-Chin Hsu, Pang-Hung Hsu, Chi-Chin Sun, Chien-Tzung Chen
Negative Pressure Wound Therapy (NPWT) is a commonly employed clinical strategy for wound healing, yet its early-stage mechanisms remain poorly understood. To address this knowledge gap and overcome the limitations of human trials, we establish an NPWT C57BL/6JNarl mouse model to investigate the molecular mechanisms involved in NPWT. In this study, we investigate the intricate molecular mechanisms through which NPWT expedites wound healing. Our focus is on NPWT's modulation of inflammatory immune responses and the concurrent orchestration of multiple signal transduction pathways, resulting in shortened coagulation time and reduced inflammation...
February 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38387686/uptake-of-ox-ldl-by-binding-to-lrp6-mediates-oxidative-stress-induced-bmscs-senescence-promoting-obesity-related-bone-loss
#12
JOURNAL ARTICLE
Senxiong Meng, Zhuan Wang, Xiaonan Liu, Ke Shen, Yuan Gu, Bin Yu, Lei Wang
Obesity has long been thought to a main cause of hyperlipidemia. As a systemic disease, the impact of obesity on organs, tissues and cells are almost all negative. However, the relationship between obesity and bone loss is most controversial. On the one hand, obesity has long been thought to a positive effect on bone due to increased mechanical loading on the skeleton, conducive to increase bone mass to accommodate the extra weight. On the other hand, obesity-related metabolic oxidative modification of low-density lipoprotein (LDL) in vivo caused the gradual increase of oxidized LDL (ox-LDL) in the bone marrow microenvironment...
February 20, 2024: Cellular Signalling
https://read.qxmd.com/read/38382851/the-predictive-value-of-serum-dickkopf-1-dickkopf-3-level-to-coronary-artery-disease-and-acute-coronary-syndrome
#13
JOURNAL ARTICLE
Panpan Xu, Yu Cao, Shuai Zhang, Xiaoling Liu, Meng Zhang, Cheng Zhang
BACKGROUND: Previous studies have already confirmed the association between Dickkopf (Dkk) protein and the occurrence and progression of atherosclerosis. However, there is limited clinical evidence regarding the serum levels of Dickkopf-1 (Dkk1) and Dickkopf-3 (Dkk3) in relation to atherosclerotic cardiovascular disease (ASCVD), particularly acute coronary syndrome (ACS). MATERIALS AND METHODS: A total of 88 healthy volunteers and 280 patients with coronary artery disease (CAD) undergoing coronary angiography for angina between October 2021 and October 2022, including 96 cases of stable angina (SA), 96 of unstable angina (UA) and 88 of acute myocardial infarction (AMI) were included finally...
February 19, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38376441/dickkopf-1-is-an-immune-infiltration-related-prognostic-biomarker-of-head-and-neck-squamous-cell-carcinoma
#14
JOURNAL ARTICLE
Chaofen Zhao, Lina Liu, Qianyong He, Yuanyuan Li, Jianglong Feng, Yue Chen, Yuxin Li, Xinyu Xu, Shaoyuan Zhu, Yuanmei Ye, Yajing Wen, Zhirui Zeng, Ding'an Zhou, Feng Jin
Immunotherapy is currently one of the most viable therapies for head and neck squamous cell carcinoma (HNSCC), characterized by high immune cell infiltration. The Wnt-signaling inhibitor and immune activation mediator, Dickkopf-1 (DKK1), has a strong correlation with tumor growth, tumor microenvironment, and, consequently, disease prognosis. Nevertheless, it is still unclear how DKK1 expression, HNSCC prognosis, and tumor-infiltrating lymphocytes are related. To better understand these associations, we examined how DKK1 expression varies across different tumor and normal tissues...
February 19, 2024: Aging
https://read.qxmd.com/read/38362044/sars-cov-2-triggers-dickkopf-1-dkk-1-modulation-of-t-helper-cells-and-lung-pathology-in-mice
#15
EDITORIAL
Yifan Wu, Freedom M Green, Stephen A Shaw, Lauren J Bonilla, Shannon E Ronca, Maria Elena Bottazzi, Farrah Kheradmand, Jill E Weatherhead
No abstract text is available yet for this article.
July 2024: Genes & Diseases
https://read.qxmd.com/read/38347292/aberrant-dna-methylation-profile-of-dickkopf-1-in-ankylosing-spondylitis
#16
JOURNAL ARTICLE
Xiaoya Sun, Yujie Deng, Man Ni, Tao Zhang, Xinqi Wang, Ye Wu, Zongwen Shuai, Faming Pan
In recent years, the impact of methylation modifications on Dickkopf-1 (DKK1) in relation to ankylosing spondylitis (AS) has remained elusive. Our objective was to investigate the potential link between DKK1 methylation patterns and transcript levels and AS susceptibility. DNA methylation level of DKK1 was measured in 82 AS and 82 healthy controls (HCs) using targeted bisulfite sequencing. In addition, the transcript level of DKK1 in peripheral blood mononuclear cells from 35 AS patients and 35 HCs was detected using real-time quantitative transcription-polymerase chain reaction...
February 12, 2024: Biochemical Genetics
https://read.qxmd.com/read/38341461/a-phase-1-2-multicenter-trial-of-dkn-01-as-monotherapy-or-in-combination-with-docetaxel-for-the-treatment-of-metastatic-castration-resistant-prostate-cancer-mcrpc
#17
JOURNAL ARTICLE
David R Wise, Russell K Pachynski, Samuel R Denmeade, Rahul R Aggarwal, Jiehui Deng, Victor Adorno Febles, Arjun V Balar, Minas P Economides, Cynthia Loomis, Shanmugapriya Selvaraj, Michael Haas, Michael H Kagey, Walter Newman, Jason Baum, Andrea B Troxel, Sarah Griglun, Dayna Leis, Nina Yang, Viktoriya Aranchiy, Sabrina Machado, Erika Waalkes, Gabrielle Gargano, Nadia Soamchand, Amrutesh Puranik, Pratip Chattopadhyay, Ezeddin Fedal, Fang-Ming Deng, Qinghu Ren, Luis Chiriboga, Jonathan Melamed, Cynthia A Sirard, Kwok-Kin Wong
BACKGROUND: Dickkopf-related protein 1 (DKK1) is a Wingless-related integrate site (Wnt) signaling modulator that is upregulated in prostate cancers (PCa) with low androgen receptor expression. DKN-01, an IgG4 that neutralizes DKK1, delays PCa growth in pre-clinical DKK1-expressing models. These data provided the rationale for a clinical trial testing DKN-01 in patients with metastatic castration-resistant PCa (mCRPC). METHODS: This was an investigator-initiated parallel-arm phase 1/2 clinical trial testing DKN-01 alone (monotherapy) or in combination with docetaxel 75 mg/m2 (combination) for men with mCRPC who progressed on ≥1 AR signaling inhibitors...
February 10, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38334454/dickkopf-1-is-expressed-in-normal-fibroblasts-during-early-stages-of-colorectal-tumorigenesis
#18
JOURNAL ARTICLE
Yushi Inomata, Masatake Kuroha, Yusuke Shimoyama, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Yoichi Kakuta, Hideaki Karasawa, Shinobu Onuma, Yoshitaka Kinouchi, Atsushi Masamune
BACKGROUND AND PURPOSE: Colorectal cancer progression from adenoma to cancer is a time-intensive process; however, the interaction between normal fibroblasts (NFs) with early colorectal tumors, such as adenomas, remains unclear. Here, we analyzed the response of the microenvironment during early tumorigenesis using co-cultures of organoids and NFs. MATERIALS AND METHODS: Colon normal epithelium, adenoma, cancer organoid, and NFs were established and co-cultured using Transwell inserts...
January 2024: Cancer Medicine
https://read.qxmd.com/read/38332694/potential-role-of-bone-metabolism-markers-in-kidney-transplant-recipients
#19
JOURNAL ARTICLE
Flávia Maria Borges Vigil, Pedro Alves Soares Vaz de Castro, Ursula Gramiscelli Hasparyk, Victória Soares Bartolomei, Ana Cristina Simões E Silva
BACKGROUND: The impact of treatments, suppressing the immune system, persistent hyperparathyroidism, and other risk factors on mineral and bone disorder (MBD) after kidney transplantation is well-known. However, there is limited knowledge about their effect on bone metabolism biomarkers. This study aimed to investigate the influence of kidney transplant on these markers, comparing them to patients undergoing hemodialysis and healthy individuals. METHODS: In this cross-sectional study, three groups were included: kidney transplant patients (n = 57), hemodialysis patients (n = 26), and healthy controls (n = 31)...
February 7, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38322254/spatial-gene-expression-profile-of-wnt-signaling-components-in-the-murine-enteric-nervous-system
#20
JOURNAL ARTICLE
Melanie Scharr, Bernhard Hirt, Peter H Neckel
INTRODUCTION: Wnt-signaling is a key regulator of stem cell homeostasis, extensively studied in the intestinal crypt and other metazoan tissues. Yet, there is hardly any data available on the presence of Wnt-signaling components in the adult enteric nervous system (ENS) in vivo . METHODS: Therefore, we employed RNAscope HiPlex-assay, a novel and more sensitive in situ hybridization technology. By amplifying target specific signals, this technique enables the detection of low abundance, tightly regulated RNA content as is the case for Wnt-signaling components...
2024: Frontiers in Immunology
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