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https://www.readbyqxmd.com/read/29441834/speech-processing-to-improve-the-perception-of-speech-in-background-noise-for-children-with-auditory-processing-disorder-and-typically-developing-peers
#1
Sheila Flanagan, Tudor-Cătălin Zorilă, Yannis Stylianou, Brian C J Moore
Auditory processing disorder (APD) may be diagnosed when a child has listening difficulties but has normal audiometric thresholds. For adults with normal hearing and with mild-to-moderate hearing impairment, an algorithm called spectral shaping with dynamic range compression (SSDRC) has been shown to increase the intelligibility of speech when background noise is added after the processing. Here, we assessed the effect of such processing using 8 children with APD and 10 age-matched control children. The loudness of the processed and unprocessed sentences was matched using a loudness model...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29438391/hearing-impairment-increases-the-risk-of-distal-radius-hip-and-spine-fractures-a-longitudinal-follow-up-study-using-a-national-sample-cohort
#2
So Young Kim, Joon Kyu Lee, Songyong Sim, Hyo Geun Choi
OBJECTIVE: Hearing impairment has been suggested to increase the risk of falls. However, most previous studies were conducted in an older population without classification of the fracture regions. This study aimed to delineate the risk of each fracture type in all age populations. METHODS: The Korean National Health Insurance Service-National Sample Cohort was collected from 2002 to 2013. A total of 4,854 severe hearing-impaired and 1,354 profound hearing-impaired participants were matched for age, group, sex, income group, and region of residence with 19,416 and 5,416 control participants, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29434063/mutations-in-otof-cldn14-slc26a4-genes-as-major-causes-of-hearing-impairment-in-dhadkai-village-jammu-kashmir-india
#3
Nishtha Pandey, Tabassum Rashid, Rajeev Jalvi, Meenakshi Sharma, Raghunath Rangasayee, Khurshid Iqbal Andrabi, Anuranjan Anand
Background & objectives: A high incidence of hearing impairment is reported from the village of Dhadkai in the State of Jammu and Kashmir, India. Prevalence of endogamy in this community suggested a common genetic basis for the disorder. A genetic study was undertaken to ascertain the basis for the high incidence of hearing impairment in this region. Methods: In a two-step approach to identify the causative mutation/s, a whole-genome-based linkage analysis of an extended family of 45 members was carried out, which included 23 affected and 22 unaffected members...
October 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29433858/hearing-loss-in-type-2-diabetes-in-association-with-diabetic-neuropathy
#4
Huihui Ren, Zhenggang Wang, Zhongyao Mao, Ping Zhang, Chunfang Wang, Aiguo Liu, Gang Yuan
BACKGROUND: Reports assessing hearing abnormalities in diabetes are debated. We aimed to evaluated auditory alterations and their possible associations with vascular and neurological dysfunction in 160 Type 2 diabetes mellitus individuals and 100 age and sex-matched healthy controls. METHODS: Participants underwent pure tone audiometry (PTA). Associations with demographic, metabolic and neuropathic variables were assessed. RESULTS: Compared with healthy controls, diabetic patients had higher mean hearing thresholds at each frequency, with statistical significance at 2-8 kHz (p <0...
February 9, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29433734/foxo-in-neural-cells-and-diseases-of-the-nervous-system
#5
Evan E Santo, Jihye Paik
The evolutionarily conserved FOXO family of transcription factors has emerged as a significant arbiter of neural cell fate and function in mammals. From the neural stem cell (NSC) state through mature neurons under both physiological and pathological conditions, they have been found to modulate neural cell survival, stress responses, lineage commitment, and neuronal signaling. Lineage-specific FOXO knockout mice have provided an invaluable tool for the dissection of FOXO biology in the nervous system. Within the NSC compartments of the brain, FOXOs are required for the maintenance of NSC quiescence and for the clearance of reactive oxygen species...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29430246/hearing-impairment-mild-cognitive-impairment-and-dementia-a-meta-analysis-of-cohort-studies
#6
REVIEW
Jingkai Wei, Yirui Hu, Li Zhang, Qiang Hao, Ruowei Yang, Haidong Lu, Xuan Zhang, Eeshwar K Chandrasekar
Background: To estimate a pooled association between hearing impairment and risk of mild cognitive impairment and dementia. Methods: PubMed, Embase, and Web of Science were searched for prospective cohort studies that examined the association between hearing impairment and risk of mild cognitive impairment and/or dementia. Random-effects models were fitted to estimate the summary risk ratios (RRs) and 95% confidence interval (CIs), which represents the pooled association between hearing impairment with risk of mild cognitive impairment and dementia, compared to subjects free of hearing impairment...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29429850/the-first-report-of-human-meningitis-and-pyogenic-ventriculitis-caused-by-streptococcus-suis-a-case-report
#7
Tomonobu Yanase, Daiichi Morii, Satoshi Kamio, Ayako Nishimura, Eri Fukao, Yuri Inose, Yutaka Honma, Nobuo Kitahara, Takayuki Yokozawa, Bin Chang, Toshimi Oda
Streptococcus suis, a gram-positive facultative anaerobe commonly found in pigs, is an emerging zoonotic pathogen. Herein, we describe a case of a 45-year-old male Japanese meat wholesaler with S. suis meningitis and pyogenic ventriculitis. S. suis was isolated from his blood and cerebrospinal fluid culture, and sequence type (ST) and serotype were confirmed to be ST1 and serotype 2, respectively, by multilocus sequence typing and the Quellung reaction. Magnetic resonance imaging (MRI) revealed right labyrinthitis and pyogenic ventriculitis...
February 8, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29429820/direct-bone-conduction-stimulation-ipsilateral-effect-of-different-transducer-attachments-in-active-transcutaneous-devices
#8
Cristina Rigato, Sabine Reinfeldt, Bo Håkansson, Karl-Johan Fredén Jansson, Erik Renvall, Måns Eeg-Olofsson
Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the contact to bone has not been addressed yet. The aim of this study is therefore to compare how different attachment methods of the transducer to the bone for direct stimulation affect the ear canal sound pressure and vibration transmission to the ipsilateral cochlea...
January 31, 2018: Hearing Research
https://www.readbyqxmd.com/read/29429769/neurodevelopmental-outcomes-of-infants-with-esophageal-atresia-and-tracheoesophageal-fistula
#9
Wegdan Mawlana, Paul Zamiara, Hilary Lane, Margaret Marcon, Eveline Lapidus-Krol, Priscilla Pl Chiu, Aideen M Moore
BACKGROUND: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is a complex disorder, and most outcome data are confined to mortality and feeding-related morbidities. Our objective was to examine mortality, growth and neurodevelopmental outcomes in a large recent cohort of infants with EA/TEF. METHODS: Single center study of EA/TEF infants referred from January 2000 to December 2015. Data collected included associated defects, neonatal morbidity and mortality and growth and neurodevelopmental outcomes at age 12-36months...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29429573/loss-of-function-mutations-in-unc45a-cause-a-syndrome-associating-cholestasis-diarrhea-impaired-hearing-and-bone-fragility
#10
Clothilde Esteve, Ludmila Francescatto, Perciliz L Tan, Aurélie Bourchany, Cécile De Leusse, Evelyne Marinier, Arnaud Blanchard, Patrice Bourgeois, Céline Brochier-Armanet, Ange-Line Bruel, Arnauld Delarue, Yannis Duffourd, Emmanuelle Ecochard-Dugelay, Géraldine Hery, Frédéric Huet, Philippe Gauchez, Emmanuel Gonzales, Catherine Guettier-Bouttier, Mina Komuta, Caroline Lacoste, Raphaelle Maudinas, Karin Mazodier, Yves Rimet, Jean-Baptiste Rivière, Bertrand Roquelaure, Sabine Sigaudy, Xavier Stephenne, Christel Thauvin-Robinet, Julien Thevenon, Jacques Sarles, Nicolas Levy, Catherine Badens, Olivier Goulet, Jean-Pierre Hugot, Nicholas Katsanis, Laurence Faivre, Alexandre Fabre
Despite the rapid discovery of genes for rare genetic disorders, we continue to encounter individuals presenting with syndromic manifestations. Here, we have studied four affected people in three families presenting with cholestasis, congenital diarrhea, impaired hearing, and bone fragility. Whole-exome sequencing of all affected individuals and their parents identified biallelic mutations in Unc-45 Myosin Chaperone A (UNC45A) as a likely driver for this disorder. Subsequent in vitro and in vivo functional studies of the candidate gene indicated a loss-of-function paradigm, wherein mutations attenuated or abolished protein activity with concomitant defects in gut development and function...
February 1, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29429119/the-development-of-a-new-tool-for-the-evaluation-of-handicap-in-elderly-the-geriatric-handicap-scale-ghs
#11
Walter Verrusio, Alessia Renzi, Giulia Spallacci, Maria Tecla Pecci, Maria Antonella Pappadà, Mauro Cacciafesta
BACKGROUND: To date, the comprehensive geriatric assessment (CGA) does not include an evaluation tool for handicap. AIM: To develop a new instrument for assessing handicap in the elderly: the Geriatric Handicap Scale (GHS). METHODS: 656 community-dwelling elderly were enrolled in this study. We identified the thematic areas investigated by the CGA which showed a significant correlation with the handicap condition (handicap yes/not) to be included in our scale (Phase 1)...
February 10, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29427525/frailty-versus-stopping-elderly-accidents-deaths-and-injuries-initiative-fall-risk-score-ability-to-predict-future-falls
#12
Rebecca S Crow, Matthew C Lohman, Dawna Pidgeon, Martha L Bruce, Stephen J Bartels, John A Batsis
OBJECTIVES: To compare the ability of frailty status to predict fall risk with that of community fall risk screening tools. DESIGN: Analysis of cross-sectional and longitudinal data from NHATS. SETTING: National Health and Aging Trend Study (NHATS) 2011-2015. PARTICIPANTS: Individuals aged 65 and older (N = 7,392). MEASUREMENTS: Fall risk was defined according to the Stopping Elderly Accidents, Deaths and Injuries (STEADI) initiative...
February 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29427504/chronic-physical-conditions-multimorbidity-and-mild-cognitive-impairment-in-low-and-middle-income-countries
#13
Ai Koyanagi, Elvira Lara, Brendon Stubbs, Andre F Carvalho, Hans Oh, Andrew Stickley, Nicola Veronese, Davy Vancampfort
OBJECTIVES: To assess the association between chronic physical conditions and multimorbidity and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). DESIGN: Nationally representative, cross-sectional, community-based study. SETTING: Six countries that participated in the World Health Organization Study on Global Ageing and Adult Health. PARTICIPANTS: Individuals aged 50 and older (N=32,715; mean age 62...
February 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29425343/prevalence-and-causes-of-musculoskeletal-impairment-in-mahabubnagar-district-telangana-state-india-results-of-a-population-based-survey
#14
Tracey Smythe, Islay Mactaggart, Hannah Kuper, G V S Murthy, Christopher Lavy, Sarah Polack
Background: Musculoskeletal impairments (MSI) are the leading contributor to global years lived with disability. Comparable epidemiological data on MSI is lacking, and are needed to inform health and rehabilitative services. This study aimed to estimate the prevalence and causes of MSI in Telangana State, India. Method: A population-based survey used probability proportionate to size and compact-segment sampling to select 51 clusters of 80 individuals (all ages)...
February 7, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29421162/the-tip-link-protein-cadherin-23-from-hearing-loss-to-cancer
#15
REVIEW
Paridhy Vanniya S, C R Srikumari Srisailapathy, Ramkumar Kunka Mohanram
Cadherin-23 is an atypical member of the cadherin superfamily, with a particularly long extracellular domain. It has been known to be a part of the tip links of the inner ear mechanosensory hair cells. Several studies have been carried out to understand the role of Cadherin-23 in the hearing mechanism and defects in the CDH23 have been associated with hearing impairment resulting from defective or absence of tip links. Recently, studies have reported the role of Cadherin-23 in several pathological conditions, including cancer, suggesting the presence of several unknown functions...
February 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29415786/effects-of-self-reported-hearing-or-vision-impairment-on-depressive-symptoms-a-population-based-longitudinal-study
#16
J H Han, H J Lee, J Jung, E-C Park
AIMS: The aims of this study were to investigate the effects of either hearing, vision or dual sensory impairment on depressive symptoms and to identify subgroups that are vulnerable and significantly affected. METHODS: Data from the 2006-2014 Korean Longitudinal Study of Aging (KLoSA) were used and a total of 5832 individuals were included in this study. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D10) scale. Sensory impairment was assessed according to the levels of self-reported hearing or vision, which were categorised as either good (excellent, very good or good) or poor (fair or poor)...
February 8, 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29415585/semantic-context-improves-speech-intelligibility-and-reduces-listening-effort-for-listeners-with-hearing-impairment
#17
Emma Holmes, Paula Folkeard, Ingrid S Johnsrude, Susan Scollie
OBJECTIVE: We investigated whether speech intelligibility and listening effort for hearing-aid users is affected by semantic context and hearing-aid setting. DESIGN: Participants heard target sentences spoken in a reverberant background of cafeteria noise and competing speech. Participants reported each sentence verbally. Eight participants also rated listening effort after each sentence. Sentence topic was either the same as, or different from, the previous target sentence...
February 7, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29408186/physical-activity-correlates-in-people-with-mild-cognitive-impairment-findings-from-six-low-and-middle-income-countries
#18
D Vancampfort, E Lara, B Stubbs, N Swinnen, M Probst, A Koyanagi
OBJECTIVES: Despite promising research showing that physical activity (PA) might improve cognitive functioning in people with mild cognitive impairment (MCI), people with MCI are less physically active compared with the general population. Therefore, the aim of this study was to assess PA correlates among community-dwelling older people with MCI in six low- and middle-income countries. DESIGN: Cross-sectional data from the World Health Organization's Study on Global Ageing and Adult Health were analysed...
February 1, 2018: Public Health
https://www.readbyqxmd.com/read/29404924/quality-of-life-in-older-adults-with-sensory-impairments-a-systematic-review
#19
REVIEW
Ya-Chuan Tseng, Sara Hsin-Yi Liu, Meei-Fang Lou, Guey-Shiun Huang
PURPOSE: Sensory impairments are common in older adults. Hearing and visual impairments affect their physical and mental health and quality of life adversely. However, systematic reviews of the relationship between hearing impairment, visual impairment, dual sensory impairment, and quality of life are scarce. The purpose of this systematic review was to determine the relationship between hearing impairment, visual impairment, dual sensory impairment, and quality of life. METHODS: Searches of EMBASE, PubMed, CINAHL, MEDLINE, Cochrane Library, and Airiti Library were conducted between January 2006 and December 2017 using the keywords "quality of life," "life satisfaction," "well-being," "hearing impairment," and "visual impairment...
February 5, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29404299/long-term-follow-up-of-retinoblastoma-survivors-experience-from-india
#20
Rachna Seth, Amitabh Singh, Vijay Guru, Bhavna Chawla, Sushmita Pathy, Savita Sapra
Background: Retinoblastoma (Rb) is the most common primary intraocular tumor of infancy and childhood. Survivors' ocular and visual problems and increased risk for subsequent malignancy are well documented, but data on long-term health status of Rb survivors are limited, this being particularly true for India. Methodology: Children who had completed treatment for Rb at least 2 years ago before and were under follow-up at the after cancer treatment clinic were evaluated...
October 2017: South Asian Journal of Cancer
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