keyword
MENU ▼
Read by QxMD icon Read
search

Hearing impairment

keyword
https://www.readbyqxmd.com/read/27913721/application-based-hearing-screening-in-the-elderly-population
#1
Leonid Livshitz, Reem Ghanayim, Carmi Kraus, Raymond Farah, Ella Even-Tov, Yaniv Avraham, Adi Sharabi-Nov, Peter Gilbey
OBJECTIVES: The effects of age-related hearing loss are severe. Early detection is essential for maximum benefit. However, most hearing-impaired adults delay obtaining treatment. Diagnostic hearing testing at an appropriate facility is impractical, and new methods for screening audiometry aim to provide easy access for patients and reliable outcomes. The purpose of this study was to examine the accuracy of application-based hearing screening in an elderly population. METHODS: The uHear application was downloaded to an iPad...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913098/succinyl-coa-synthetase-sucla2-deficiency-in-two-siblings-with-impaired-activity-of-other-mitochondrial-oxidative-enzymes-in-skeletal-muscle-without-mitochondrial-dna-depletion
#2
Xiaoping Huang, Jirair K Bedoyan, Didem Demirbas, David J Harris, Alexander Miron, Simone Edelheit, George Grahame, Suzanne D DeBrosse, Lee-Jun Wong, Charles L Hoppel, Douglas S Kerr, Irina Anselm, Gerard T Berry
Mutations in SUCLA2 result in succinyl-CoA ligase (ATP-forming) or succinyl-CoA synthetase (ADP-forming) (A-SCS) deficiency, a mitochondrial tricarboxylic acid cycle disorder. The phenotype associated with this gene defect is largely encephalomyopathy. We describe two siblings compound heterozygous for SUCLA2 mutations, c.985A>G (p.M329V) and c.920C>T (p.A307V), with parents confirmed as carriers of each mutation. We developed a new LC-MS/MS based enzyme assay to demonstrate the decreased SCS activity in the siblings with this unique genotype...
November 12, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27908066/discrimination-of-amplitude-modulation-depth-by-subjects-with-normal-and-impaired-hearing
#3
Josef Schlittenlacher, Brian C J Moore
The loudness recruitment associated with cochlear hearing loss increases the perceived amount of amplitude modulation (AM), called "fluctuation strength." For normal-hearing (NH) subjects, fluctuation strength "saturates" when the AM depth is high. If such saturation occurs for hearing-impaired (HI) subjects, they may show poorer AM depth discrimination than NH subjects when the reference AM depth is high. To test this hypothesis, AM depth discrimination of a 4-kHz sinusoidal carrier, modulated at a rate of 4 or 16 Hz, was measured in a two-alternative forced-choice task for reference modulation depths, mref, of 0...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27908030/influences-of-noise-interruption-and-information-bearing-acoustic-changes-on-understanding-simulated-electric-acoustic-speech
#4
Christian Stilp, Gail Donaldson, Soohee Oh, Ying-Yee Kong
In simulations of electrical-acoustic stimulation (EAS), vocoded speech intelligibility is aided by preservation of low-frequency acoustic cues. However, the speech signal is often interrupted in everyday listening conditions, and effects of interruption on hybrid speech intelligibility are poorly understood. Additionally, listeners rely on information-bearing acoustic changes to understand full-spectrum speech (as measured by cochlea-scaled entropy [CSE]) and vocoded speech (CSECI), but how listeners utilize these informational changes to understand EAS speech is unclear...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27900753/-issues-related-to-screening-and-caring-for-newborns-with-hearing-impairments
#5
Mei-Show Liou, Ying Tsao
The critical period for auditory development in humans begins at around the 20th gestational week and continues until 3 years of age. Both genetic and environmental factors are known to cause impaired hearing. Without early identification and intervention, hearing-impaired children face a high risk of experiencing significant difficulties with speech and language development, social behavior, and emotional functioning. Two types of commonly used hearing screening technologies include transient evoked otoacoustic emission (TEOAE) and automated auditory brainstem response (aABR)...
December 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27897126/recognition-of-deep-band-modulated-consonants-in-quiet-and-noise-in-older-individuals-with-and-without-hearing-loss
#6
Hemanth Narayan Shetty, Vishal Kooknoor
OBJECTIVE: The purpose of the present study was to investigate the effects of temporal envelope enhancement using deep band modulation (DBM) on consonant identification scores (CIS) and transfer of features such as place of articulation, manner of articulation, and voicing. MATERIALS AND METHODS: Data were collected from four groups of ten participants each. These were grouped into younger (YNH) and older adult (ONH) individuals with normal hearing and younger (YHI) and older adult (OHI) individuals with hearing impairment who had mild to moderate sensorineural hearing loss...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27897125/a-comparison-of-thresholds-of-auditory-steady-state-response-and-auditory-brainstem-response-in-healthy-term-babies
#7
Onur Çelik, Görkem Eskiizmir, Uzdan Uz
OBJECTIVE: The goal of this study was to assess the effectiveness of auditory steady-state response (ASSR), determine the cut-off values for each frequency, and detect the best correlated frequencies when compared with the auditory brainstem response (ABR) thresholds in term babies under the age of 12 months. MATERIALS AND METHODS: In total, 88 term babies with a mean age of 2.98 (1-11) months (174 ears) underwent ASSR and ABR tests. The ASSR thresholds for the frequencies of 500, 1000, 2000, and 4000 Hz were compared with the hearing level of the ABR thresholds...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27896493/hearing-impairment-and-risk-of-alzheimer-s-disease-a-meta-analysis-of-prospective-cohort-studies
#8
REVIEW
Yuqiu Zheng, Shengnuo Fan, Wang Liao, Wenli Fang, Songhua Xiao, Jun Liu
Observational studies suggested an association between hearing impairment and cognitive disorders. However, whether hearing impairment is an independent risk factor or a harbinger of Alzheimer's disease remains controversial. Our goal was to assess the association between hearing impairment (HI) and the risk of Alzheimer's disease (AD) by conducting a meta-analysis of prospective cohort studies. We comprehensively searched the PubMed, Embase, Web of Science and Cochrane Library databases on January 19, 2016 to incorporate all the prospective cohort studies meeting the inclusion criteria to perform a systematic review and meta-analysis...
November 28, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27896132/divergent-clinical-outcomes-of-alpha-glucosidase-enzyme-replacement-therapy-in-two-siblings-with-infantile-onset-pompe-disease-treated-in-the-symptomatic-or-pre-symptomatic-state
#9
Takashi Matsuoka, Yoshiyuki Miwa, Makiko Tajika, Madoka Sawada, Koichiro Fujimaki, Takashi Soga, Hideshi Tomita, Shigeru Uemura, Ichizo Nishino, Tokiko Fukuda, Hideo Sugie, Motomichi Kosuga, Torayuki Okuyama, Yoh Umeda
Pompe disease is an autosomal recessive, lysosomal glycogen storage disease caused by acid α-glucosidase deficiency. Infantile-onset Pompe disease (IOPD) is the most severe form and is characterized by cardiomyopathy, respiratory distress, hepatomegaly, and skeletal muscle weakness. Untreated, IOPD generally results in death within the first year of life. Enzyme replacement therapy (ERT) with recombinant human acid alpha glucosidase (rhGAA) has been shown to markedly improve the life expectancy of patients with IOPD...
December 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27895549/the-repeatable-battery-for-the-assessment-of-neuropsychological-status-for-hearing-impaired-individuals-rbans-h-before-and-after-cochlear-implantation-a-protocol-for-a-prospective-longitudinal-cohort-study
#10
Annes J Claes, Griet Mertens, Annick Gilles, Anouk Hofkens-Van den Brandt, Erik Fransen, Vincent Van Rompaey, Paul Van de Heyning
Background: Currently, an independent relationship between hearing loss and cognitive decline in older adults is suggested by large prospective studies. In general, cochlear implants improve hearing and the quality of life in severely to profoundly hearing impaired older persons. However, little is known about the effects of cochlear implantation on the cognitive evolution in this population. Aim of the study: The primary goal of this prospective, longitudinal cohort study is to explore the cognitive profile of severely to profoundly postlingually hearing impaired subjects before and after cochlear implantation...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27895002/impression-material-in-the-external-and-middle-ear-an-overview-of-the-literature-and-a-stepwise-approach-for-removal
#11
Froukje Verdam, Rinze Tange, Hans Thomeer
Here, we provide a literature overview of cases with protruding molding material for earplugs or hearing aids and subsequent required treatment, including our own cases. Patients at risk are those with impaired tympanic membranes or who previously underwent otologic surgery. Symptoms such as otalgia, tinnitus, and vertigo are alarming but do not always arise. In case of doubt, a CT scan is of additive value to prepare for adequate surgical removal and to limit potential damage. A stepwise approach for the clinician on how to address these challenging cases is presented, based upon the literature and our own experience...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27894440/when-autistic-behavior-suggests-a-disease-other-than-classic-autism
#12
REVIEW
Mark D Simms
Most neurodevelopmental disorders are defined by their clinical symptoms and many disorders share common features. Recently there has been an increase in the number of children diagnosed with autism spectrum disorder, although concerns have been raised about the accuracy of the reported prevalence rates. This article reviews the essential features of autism spectrum disorder and describes other conditions that may include similar symptoms that may be misdiagnosed as autism spectrum disorder (primary communication disorders, anxiety disorders, attachment disorders, intellectual disability, vision and hearing impairment, and normal variations)...
February 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/27893791/toward-a-nonspeech-test-of-auditory-cognition-semantic-context-effects-in-environmental-sound-identification-in-adults-of-varying-age-and-hearing-abilities
#13
Valeriy Shafiro, Stanley Sheft, Molly Norris, George Spanos, Katherine Radasevich, Paige Formsma, Brian Gygi
OBJECTIVE: Sounds in everyday environments tend to follow one another as events unfold over time. The tacit knowledge of contextual relationships among environmental sounds can influence their perception. We examined the effect of semantic context on the identification of sequences of environmental sounds by adults of varying age and hearing abilities, with an aim to develop a nonspeech test of auditory cognition. METHOD: The familiar environmental sound test (FEST) consisted of 25 individual sounds arranged into ten five-sound sequences: five contextually coherent and five incoherent...
2016: PloS One
https://www.readbyqxmd.com/read/27891689/deficit-in-acoustic-signal-in-noise-detection-in-glycine-receptor-%C3%AE-3-subunit-knockout-mice
#14
Konstantin Tziridis, Stefanie Buerbank, Volker Eulenburg, Julia Dlugaiczyk, Holger Schulze
Hearing is an essential sense for communication in animals and humans. Normal function of the cochlea of higher vertebrates relies on a fine-tuned interplay of afferent and efferent innervation of both inner and outer hair cells. Efferent inhibition is controlled via olivocochlear feedback loops, mediated mainly by acetylcholine, γ-aminobutyric acid (GABA) and glycine, and is one of the first sites affected by synapto- and neuropathy in the development of hearing loss. While the functions of acetylcholine, GABA, and other inhibitory transmitters within these feedback loops are at least partially understood, especially the function of glycine still remains elusive...
November 27, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27891585/novel-mutations-in-kars-cause-hypertrophic-cardiomyopathy-and-combined-mitochondrial-respiratory-chain-defect
#15
Daniela Verrigni, Daria Diodato, Michela Di Nottia, Alessandra Torraco, Emanuele Bellacchio, Teresa Rizza, Giulia Tozzi, Margherita Verardo, Fiorella Piemonte, Giorgio Tasca, Adele D'Amico, Enrico Bertini, Rosalba Carrozzo
Mutations in KARS, which encodes for both mitochondrial and cytoplasmic lysyl-tRNA synthethase, have been so far associated with three different phenotypes: the recessive form of Charcot Mary-Tooth polyneuropathy, the autosomal recessive non-syndromic hearing loss and the last recently described condition related to congenital visual impairment and progressive microcephaly. Here we report the case of a 14-years-old-girl with severe cardiomyopathy associated to mild psychomotor delay and mild myopathy; moreover, a diffuse reduction of cytochrome C oxidase (COX, complex IV) and a combined enzymatic defect of complex I (CI) and IV (CIV) was evident in muscle biopsy...
November 28, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27891365/visual-function-and-ocular-status-in-children-with-disabilities-in-special-schools-of-northern-india
#16
Gurvinder Kaur, Satish Thomas, Mahesh Jindal, S M Bhatti
INTRODUCTION: Children with disabilities (other than visual impairment) are at a higher risk of visual impairment as compared to normal population. Majority of the ocular disorders, like refractive errors and strabismus, are easily treatable. As these children depend on their visual inputs for social and academic activities, an early detection and prompt treatment of even a minor visual problem is of utmost importance for them. AIM: To assess the visual function and ocular status of children with disabilities other than visual impairment and to identify the preventable and treatable causes of visual impairment...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890673/functional-validation-of-abhd12-mutations-in-the-neurodegenerative-disease-pharc
#17
Angèle Tingaud-Sequeira, Demetrio Raldúa, Julie Lavie, Guilaine Mathieu, Magali Bordier, Anja Knoll-Gellida, Pierre Rambeau, Isabelle Coupry, Michèle André, Eva Malm, Claes Möller, Sten Andreasson, Nanna D Rendtorff, Lisbeth Tranebjærg, Michel Koenig, Didier Lacombe, Cyril Goizet, Patrick J Babin
ABHD12 mutations have been linked to neurodegenerative PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and early-onset cataract), a rare, progressive, autosomal, recessive disease. Although ABHD12 is suspected to play a role in the lysophosphatidylserine and/or endocannabinoid pathways, its precise functional role(s) leading to PHARC disease had not previously been characterized. Cell and zebrafish models were designed to demonstrate the causal link between an identified new missense mutation p...
November 23, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27888324/learning-to-echolocate-in-sighted-people-a-correlational-study-on-attention-working-memory-and-spatial-abilities
#18
M R Ekkel, R van Lier, B Steenbergen
Echolocation can be beneficial for the orientation and mobility of visually impaired people. Research has shown considerable individual differences for acquiring this skill. However, individual characteristics that affect the learning of echolocation are largely unknown. In the present study, we examined individual factors that are likely to affect learning to echolocate: sustained and divided attention, working memory, and spatial abilities. To that aim, sighted participants with normal hearing performed an echolocation task that was adapted from a previously reported size-discrimination task...
November 25, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27888040/evidence-that-hidden-hearing-loss-underlies-amplitude-modulation-encoding-deficits-in-individuals-with-and-without-tinnitus
#19
Brandon T Paul, Ian C Bruce, Larry E Roberts
Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden from the audiogram has been proposed to underlie deficits in temporal coding ability observed among individuals with otherwise normal hearing, and to be present in individuals experiencing chronic tinnitus with clinically normal audiograms. We tested whether these individuals may have hidden synaptic losses on auditory nerve fibers with low spontaneous rates of firing (low-SR fibers) that are important for coding suprathreshold sounds in noise while high-SR fibers determining threshold responses in quiet remain relatively unaffected...
November 22, 2016: Hearing Research
https://www.readbyqxmd.com/read/27882946/er-stress-inhibitor-attenuates-hearing-loss-and-hair-cell-death-in-cdh23-erl-erl-mutant-mice
#20
Juan Hu, Bo Li, Luke Apisa, Heping Yu, Shami Entenman, Min Xu, Ruben Stepanyan, Bo-Jhih Guan, Ulrich Müller, Maria Hatzoglou, Qing Yin Zheng
Hearing loss is one of the most common sensory impairments in humans. Mouse mutant models helped us to better understand the mechanisms of hearing loss. Recently, we have discovered that the erlong (erl) mutation of the cadherin23 (Cdh23) gene leads to hearing loss due to hair cell apoptosis. In this study, we aimed to reveal the molecular pathways upstream to apoptosis in hair cells to exploit more effective therapeutics than an anti-apoptosis strategy. Our results suggest that endoplasmic reticulum (ER) stress is the earliest molecular event leading to the apoptosis of hair cells and hearing loss in erl mice...
November 24, 2016: Cell Death & Disease
keyword
keyword
11266
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"