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https://www.readbyqxmd.com/read/28214332/comparison-of-several-white-matter-tracts-in-feline-and-canine-brain-by-using-magnetic-resonance-diffusion-tensor-imaging
#1
Olivier Jacqmot, Bert Van Thielen, Alex Michotte, Inneke Willekens, Filip Verhelle, Peter Goossens, Filip De Ridder, Jan Pieter Clarys, Anne Vanbinst, Cindy Peleman, Johan de Mey
Recently, we published a first anatomical Diffusion Tensor Imaging (DTI) atlas regarding white matter tracts in the canine brain. The purpose of this study was to show the significance of DTI in the revelation of the white matter fibres in the feline brain (i.e. to obtain an anatomical DTI atlas of images) and to descriptively compare these to previously obtained white matter fibre images of the canine brain. DTI MR Images of 4 cats euthanised for reasons other than neurological disorders were obtained with a 3 T system...
February 18, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28214288/an-accelerator-mass-spectrometry-enabled-microtracer-study-to-evaluate-the-first-pass-effect-on-the-absorption-of-yh4808
#2
Anhye Kim, Byung-Yong Yu, Stephen R Dueker, Kwang-Hee Shin, Hwa Suk Kim, Hyungmi Ahn, Joo-Youn Cho, Kyung-Sang Yu, In-Jin Jang, Howard Lee
(14) C-labeled YH4808, a novel potassium-competitive acid blocker, was intravenously administered as a microtracer at 80 μg (11.8 kBq or 320 nCi) concomitantly with the non-radiolabeled oral drug at 200 mg to determine the absolute bioavailability and to assess the effect of pharmacogenomics on the oral absorption of YH4808. The absolute bioavailability was low and highly variable (mean, 10.1%; range, 2.3-19.3%), and M3 and M8, active metabolites of YH4808, were formed 22.6- and 38.5-fold higher after oral administration than intravenous administration, respectively...
February 18, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28213512/27-hydroxycholesterol-impairs-neuronal-glucose-uptake-through-an-irap-glut4-system-dysregulation
#3
Muhammad-Al-Mustafa Ismail, Laura Mateos, Silvia Maioli, Paula Merino-Serrais, Zeina Ali, Maria Lodeiro, Eric Westman, Eran Leitersdorf, Balázs Gulyás, Lars Olof-Wahlund, Bengt Winblad, Irina Savitcheva, Ingemar Björkhem, Angel Cedazo-Mínguez
Hypercholesterolemia is associated with cognitively deteriorated states. Here, we show that excess 27-hydroxycholesterol (27-OH), a cholesterol metabolite passing from the circulation into the brain, reduced in vivo brain glucose uptake, GLUT4 expression, and spatial memory. Furthermore, patients exhibiting higher 27-OH levels had reduced (18)F-fluorodeoxyglucose uptake. This interplay between 27-OH and glucose uptake revealed the engagement of the insulin-regulated aminopeptidase (IRAP). 27-OH increased the levels and activity of IRAP, countered the IRAP antagonist angiotensin IV (AngIV)-mediated glucose uptake, and enhanced the levels of the AngIV-degrading enzyme aminopeptidase N (AP-N)...
February 17, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28213263/determination-of-n-nitrosodiethanolamine-in-cosmetic-products-by-reversed-phase-dispersive-liquid-liquid-microextraction-followed-by-liquid-chromatography
#4
Alberto Chisvert, Juan L Benedé, María Peiró, Isabel Pedrón, Amparo Salvador
A new analytical method for the determination of N-nitrosodiethanolamine (NDELA), a very harmful compound not allowed in cosmetic products, is presented. The method is based on a new approach of dispersive liquid-liquid microextraction (DLLME) useful for extraction of highly polar compounds, called reversed-phase DLLME (RP-DLLME), followed by liquid chromatography-ultraviolet/visible (LC-UV/Vis) determination. The variables involved in the RP-DLLME process were studied to provide the best enrichment factors...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213256/carbon-polydimethylsiloxane-based-integratable-optical-technology-for-spectroscopic-analysis
#5
Hiroaki Nomada, Kinichi Morita, Hirokazu Higuchi, Hiroaki Yoshioka, Yuji Oki
A polydimethylsiloxane (PDMS)-based optical system has been demonstrated. To suppress intense background radiation due to multiple internal scatting in a transparent material, a composite structure of a carbon-PDMS compound and PDMS was proposed. The index matching of the real part of the refractive index can suppress internal scattering, and an absorption of 99-99.7% was attained by using carbon micro particles and carbon nano tubes. The black-PDMS light channel functions as a light filter for straight pass, and an optical density of 5 was obtained by bending the filter...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213244/a-novel-pyrogallol-red-based-assay-to-assess-catalase-activity-optimization-by-response-surface-methodology
#6
Mohamed Abderrahim, Silvia M Arribas, Luis Condezo-Hoyos
Pyrogallol red (PGR) was identified as a novel optical probe for the detection of hydrogen peroxide (H2O2) based on horseradish peroxidase (HRP)-catalyzed oxidation. Response surface methodology (RSM) was applied as a tool to optimize the concentrations of PGR (100µmolL(-1)), HRP (1UmL(-1)) and H2O2 (250µmolL(-1)) and used to develop a sensitive PGR-based catalase (CAT) activity assay (PGR-CAT assay). N-ethylmaleimide -NEM- (102mmolL(-1)) was used to avoid interference produced by thiol groups while protecting CAT activity...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213200/validation-of-a-quantitative-method-to-measure-neural-respiratory-drive-in-children-during-sleep
#7
Sandra Ya-Chu Chuang, Arthur Teng, Jane Elizabeth Butler, Simon Charles Gandevia, Hiran Selvadurai, Adam Jaffe
AIMS: Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep. METHOD: Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-investigator reproducibility. Effects of different band pass filter settings (20-100Hz vs 10-1000Hz) on sEMGdi amplitude were evaluated. RESULTS: Mean sEMGdi from 45 children aged 4...
February 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28213114/hierarchical-control-of-procedural-and-declarative-category-learning-systems
#8
Benjamin O Turner, Matthew J Crossley, F Gregory Ashby
Substantial evidence suggests that human category learning is governed by the interaction of multiple qualitatively distinct neural systems. In this view, procedural memory is used to learn stimulus-response associations, and declarative memory is used to apply explicit rules and test hypotheses about category membership. However, much less is known about the interaction between these systems: how is control passed between systems as they interact to influence motor resources? Here, we used fMRI to elucidate the neural correlates of switching between procedural and declarative categorization systems...
February 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28212900/basic-educational-needs-of-midwifery-students-for-taking-the-role-of-an-assistance-in-disaster-situations-a-cross-sectional-study-in-iran
#9
Z Taghizadeh, M Khoshnam Rad, A Montazeri
BACKGROUND: After disasters, the disaster medical assistance team composed of skilful healthcare staff should be available at the disaster site for providing care to disaster's victims. It is believed that midwives are at the front line of the disaster management team and should be prepared for providing care to mothers and children. OBJECTIVES: To investigate the midwifery students' basic educational needs for taking the role of an assistant in disaster situations...
January 22, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28212848/major-vectors-and-vector-borne-diseases-in-small-ruminants-in-ethiopia-a-systematic-review
#10
REVIEW
Kassahun Asmare, Takele Abayneh, Berhanu Sibhat, Dessie Shiferaw, Barbara Szonyi, Randi I Krontveit, Eystein Skjerve, Barbara Wieland
Vector-borne diseases are among major health constraints of small ruminant in Ethiopia. While various studies on single vector-borne diseases or presence of vectors have been conducted, no summarized evidence is available on the occurrence of these diseases and the related vectors. This systematic literature review provides a comprehensive summary on major vectors and vector-borne diseases in small ruminants in Ethiopia. Search for published and unpublished literature was conducted between 8th of January and 25th of June 2015...
February 14, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28212087/dual-deep-network-for-visual-tracking
#11
Zhizhen Chi, Hongyang Li, Huchuan Lu, Minghsuan Yang
Visual tracking addresses the problem of identifying and localizing an unknown target in a video given the target specified by a bounding box in the first frame. In this paper, we propose a dual network to better utilize features among layers for visual tracking. It is observed that features in higher layers encode semantic context while its counterparts in lower layers are sensitive to discriminative appearance. Thus we exploit the hierarchical features in different layers of a deep model and design a dual structure to obtain better feature representation from various streams, which is rarely investigated in previous work...
February 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28212081/a-comparative-analysis-of-cmut-receiving-architectures-for-design-optimization-of-integrated-transceiver-front-ends
#12
Marco Sautto, Alessandro Stuart Savoia, Fabio Quaglia, Giosue Caliano, Andrea Mazzanti
A formal comparison between fundamental RX amplifier configurations for Capacitive Micromachined Ultrasonic Transducers (CMUT) is proposed in this paper. The impact on both RX and the pulse-echo frequency response and on the output SNR are thoroughly analysed and discussed. It is shown that the resistive-feedback amplifier yields a band-pass RX frequency response, while both open-loop voltage and capacitivefeedback amplifiers exhibit a low-pass frequency response. For a given power dissipation, it is formally proved that a capacitivefeedback amplifier provides a remarkable SNR improvement against the commonly adopted resistive feedback stage, achieved at the expense of a reduced pulse-echo center frequency, making its use convenient in low and mid-frequency ultrasound imaging applications...
February 13, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28211943/a-general-statistical-framework-for-subgroup-identification-and-comparative-treatment-scoring
#13
Shuai Chen, Lu Tian, Tianxi Cai, Menggang Yu
Many statistical methods have recently been developed for identifying subgroups of patients who may benefit from different available treatments. Compared with the traditional outcome-modeling approaches, these methods focus on modeling interactions between the treatments and covariates while by-pass or minimize modeling the main effects of covariates because the subgroup identification only depends on the sign of the interaction. However, these methods are scattered and often narrow in scope. In this article, we propose a general framework, by weighting and A-learning, for subgroup identification in both randomized clinical trials and observational studies...
February 17, 2017: Biometrics
https://www.readbyqxmd.com/read/28211518/limited-options-for-low-global-warming-potential-refrigerants
#14
Mark O McLinden, J Steven Brown, Riccardo Brignoli, Andrei F Kazakov, Piotr A Domanski
Hydrofluorocarbons, currently used as refrigerants in air-conditioning systems, are potent greenhouse gases, and their contribution to climate change is projected to increase. Future use of the hydrofluorocarbons will be phased down and, thus replacement fluids must be found. Here we show that only a few pure fluids possess the combination of chemical, environmental, thermodynamic, and safety properties necessary for a refrigerant and that these fluids are at least slightly flammable. We search for replacements by applying screening criteria to a comprehensive chemical database...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28211367/high-quality-four-dimensional-cone-beam-ct-reconstruction-using-motion-compensated-total-variation-regularization
#15
Hua Zhang, Jianhua Ma, Zhaoying Bian, Dong Zeng, Qianjin Feng, Wufan Chen
Four dimensional cone-beam computed tomography (4D-CBCT) has great potential clinical value because its ability to describe tumor and organ motion. But the challenge in 4D-CBCT reconstruction is the limited number of projections at each phase, which resulting in the reconstruction full of noise and streak artifacts with the conventional analytical algorithms. To address this problem, in this paper, we propose a motion compensated total variation regularization approach which tries to maximum explore the temporal coherence of the spatial structures among 4D-CBCT phases...
February 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28211116/ac-dielectrophoretic-manipulation-and-electroporation-of-vaccinia-virus-using-carbon-nanoelectrode-arrays
#16
Foram Ranjeet Madiyar, Sherry Basset, Omer Farooq, Stefan Rothenburg, Christopher Culbertson, Jun Li
This paper reports the capture and detection of vaccinia virus particles based on AC dielectrophoresis (DEP) and electrochemical impedance measurements employing an embedded vertically aligned carbon nanofiber (VACNF) nanoelectrode array (NEA) versus a macroscopic indium-tin-oxide (ITO) transparent electrode in a "points-and-lid" configuration. The nano-DEP device was fabricated by bonding two SU-8 covered electrodes patterned using photolithography. The bottom electrode contains a 200 × 200 μm(2) active region on a randomly distributed NEA and the top electrode contains a microfluidic channel in SU-8 spin-coated on ITO to guide the flow of the virus solution...
February 17, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28210889/correlation-between-physicochemical-properties-of-modified-clinoptilolite-and-its-performance-in-the-removal-of-ammonia-nitrogen
#17
Yingbo Dong, Hai Lin, Yinhai He
The physicochemical properties of the 24 modified clinoptilolite samples and their ammonia-nitrogen removal rates were measured to investigate the correlation between them. The modified clinoptilolites obtained by acid modification, alkali modification, salt modification, and thermal modification were used to adsorb ammonia-nitrogen. The surface area, average pore width, macropore volume, mecropore volume, micropore volume, cation exchange capacity (CEC), zeta potential, silicon-aluminum ratios, and ammonia-nitrogen removal rate of the 24 modified clinoptilolite samples were measured...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28210796/optogenetic-switches-for-light-controlled-gene-expression-in-yeast
#18
REVIEW
Francisco Salinas, Vicente Rojas, Verónica Delgado, Eduardo Agosin, Luis F Larrondo
Light is increasingly recognized as an efficient means of controlling diverse biological processes with high spatiotemporal resolution. Optogenetic switches are molecular devices for regulating light-controlled gene expression, protein localization, signal transduction and protein-protein interactions. Such molecular components have been mainly developed through the use of photoreceptors, which upon light stimulation undergo conformational changes passing to an active state. The current repertoires of optogenetic switches include red, blue and UV-B light photoreceptors and have been implemented in a broad spectrum of biological platforms...
February 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28210786/females-younger-patients-and-patients-with-high-bmi-have-the-highest-pre-operative-knee-awareness-measured-using-the-forgotten-joint-score
#19
Dana Li, A Troelsen, L Ingelsrud, H Husted, K Gromov
PURPOSE: The Forgotten Joint Score (FJS) is a novel measurement for patients' awareness of their knee in daily life. By identifying factors that could explain pre-operative FJS levels, the clinician could better prioritize and single out patients who would benefit most from TKA. The aim of this study was to identify possible factors that may explain the variance of pre-operative FJS levels and evaluate the relationship between pre-operative FJS and pre-operative Oxford Knee Score (OKS)...
February 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28209314/connection-between-bilateral-temporal-regions-tractography-using-human-connectome-data-and-diffusion-spectrum-imaging
#20
Peng-Hu Wei, Zhi-Qi Mao, Fei Cong, Bo Wang, Zhi-Pei Ling, Shu-Li Liang, Xin-Guang Yu
Temporal lobe epilepsy often propagates inter-hemispherically. Although the pathway of the propagation was verified by electrophysiology, the trajectory remains poorly defined. DTI can depict fiber trajectory but it has limited angular resolution and cannot adequately assess cortical regions. We visualized potential pathways of bitemporal epilepsy propagation using diffusion spectrum imaging (DSI) with data consisting of 8 groups of 514 directions and diffusion templates of 842 subjects from the human connectome project (HCP)...
February 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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