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https://www.readbyqxmd.com/read/29679471/long-lived-15n-hyperpolarization-and-rapid-relaxation-as-a-potential-basis-for-repeated-first-pass-perfusion-imaging-marked-effects-of-deuteration-and-temperature
#1
Talia Harris, Ayelet Gamliel, Sivaranjan Uppala, Atara Nardi-Schreiber, Jacob Sosna, J Moshe Gomori, Rachel Katz-Brull
Deuteration of the exchangeable hydrogens of [15N2]urea was found here to prolong the T1 of the 15N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [15N2]urea, compared to [13C]urea - a pre-clinically proven perfusion agent, makes [15N2]urea a promising perfusion agent. The molecular parameters that may lead to this profound effect were assessed by investigating small molecules with different molecular structures containing 15N sites bound to labile protons and determining the hyperpolarized 15N T1 in H2O and D2O...
April 21, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29679349/timeline-bioavailability-of-magnesium-compounds-in-hours-which-magnesium-compound-works-best
#2
Nazan Uysal, Servet Kizildag, Zeynep Yuce, Guven Guvendi, Sevim Kandis, Basar Koc, Aslı Karakilic, Ulas M Camsari, Mehmet Ates
Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues...
April 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29678732/improving-feeding-powder-distribution-to-the-compaction-zone-in-the-roller-compaction
#3
Mingzhe Yu, Chalak Omar, Alexander Schmidt, James D Litster, Agba D Salman
In the roller compaction process, powder flow properties have a significant influence on the uniformity of the ribbon properties. The objective of this work was to improve the powder flow in the feeding zone by developing novel feeding guiders which are located in the feeding zone close to the rollers in the roller compactor (side sealing system). Three novel feeding guiders were designed by 3D printing and used in the roller compactor, aiming to control the amount of powder passing across the roller width...
April 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29676591/a-retrospective-observational-study-on-biological-drug-treatment-in-a-daily-practice-serving-patients-with-psoriasis-in-japan
#4
Chika Ohata, Bungo Ohyama, Aya Nanri, Takako Shintani, Takekuni Nakama
BACKGROUND: In Japan, more than 5 years have passed since emergence of the first 3 biologics, infliximab, adalimumab, and ustekinumab, became available in daily practice; however, no data for drug survival was reported from Japan. OBJECTIVE: To study the long-term drug survival of infliximab, adalimumab, and ustekinumab used for Japanese psoriatic patients. METHODS: We retrieved data on all patients treated with biological agents and calculated the long-term drug survival for infliximab, adalimumab, and ustekinumab using our psoriasis registry (Kurume Psoriasis Registry: KURUPR) consisted of 343 patients by the end of March 2017...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676463/evaluation-of-machine-log-files-mc-based-treatment-planning-and-delivery-qa-as-compared-to-arccheck-qa
#5
Carl W Stanhope, Douglas G Drake, Jian Liang, Markus Alber, Matthias Söhn, Charbel Habib, Virgil Willcut, Di Yan
PURPOSE: A treatment planning/delivery QA tool using linac log files (LF) and Monte Carlo (MC) dose calculation is investigated as a standalone alternative to phantom-based patient-specific QA (ArcCHECK (AC)). METHODS: Delivering a variety of fields onto MapCHECK2 and ArcCHECK, diode sensitivity dependence on dose rate (in-field) and energy (primarily out-of-field) was quantified. AC and LF QAs were analyzed w.r.t. delivery complexity by delivering 12x12cm static fields/arcs comprised of varying numbers of abutting sub-fields onto ArcCHECK...
April 20, 2018: Medical Physics
https://www.readbyqxmd.com/read/29676425/mechanistic-insights-into-the-interaction-between-energetic-oxygen-ions-and-nanosized-znfe-2-o-4-xas-xmcd-investigations
#6
Jitendra Pal Singh, Baljeet Kaur, Aditya Sharma, So Hee Kim, Sanjeev Gautam, Ramesh Chandra Srivastava, Navdeep Goyal, Weol Cheol Lim, H-J Lin, J M Chen, K Asokan, D Kanjilal, Sung Ok Won, Ik-Jae Lee, Keun Hwa Chae
The interactions of energetic ions with multi-cation compounds and their consequences in terms of changes in the local electronic structure, which may facilitate intriguing hybridization between O 2p and metal d orbitals and magnetic ordering, are the subject of debate and require a deep understanding of energy transfer processes and magnetic exchange mechanisms. In this study, nanocrystals of ZnFe2O4 were exposed to O7+ ions with an energy of 100 MeV to understand, qualitatively and quantitatively, the metal-ligand field interactions, cation migration and magnetic exchange interactions by employing X-ray absorption fine structure measurements and X-ray magnetic circular dichroism to get deeper mechanistic insights...
April 20, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29676235/current-and-promising-therapies-in-autosomal-recessive-ataxias
#7
Vincent Picher-Martel, Nicolas Dupre
BACKGROUND & OBJECTIVE: Ataxia is clinically characterized by unsteady gait and imbalance. Cerebellar disorders may arise from many causes such as metabolic diseases, stroke or genetic mutations. The genetic causes are classified by mode of inheritance and include autosomal dominant, X-linked and autosomal recessive ataxias. Many years have passed since the description of Friedreich's ataxia, the most common autosomal recessive ataxia, and mutations in many other genes have now been described...
April 18, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29676222/clustering-performances-in-the-nba-according-to-players-anthropometric-attributes-and-playing-experience
#8
Shaoliang Zhang, Alberto Lorenzo, Miguel-Angel Gómez, Nuno Mateus, Bruno Gonçalves, Jaime Sampaio
The aim of this study was: (i) to group basketball players into similar clusters based on a combination of anthropometric characteristics and playing experience; and (ii) explore the distribution of players (included starters and non-starters) from different levels of teams within the obtained clusters. The game-related statistics from 699 regular season balanced games were analyzed using a two-step cluster model and a discriminant analysis. The clustering process allowed identifying five different player profiles: Top height and weight (HW) with low experience, TopHW-LowE; Middle HW with middle experience, MiddleHW-MiddleE; Middle HW with top experience, MiddleHW-TopE; Low HW with low experience, LowHW-LowE; Low HW with middle experience, LowHW-MiddleE...
April 20, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29675983/the-natural-history-of-asymptomatic-calyceal-stones
#9
Maitrey Padmasambhav Darrad, Sachin Yallappa, John Metcalfe, Kesavapillai Subramonian
OBJECTIVES: To evaluate the outcomes of patients with incidentally detected asymptomatic calyceal stones on active surveillance, and to identify risk factors for stone-related adverse events. SUBJECTS & METHODS: In this retrospective case series, we identified all renal units with non-contrast CT diagnosed asymptomatic calyceal stones in a single reference centre between August 2005 and August 2016. Primary endpoints were spontaneous stone passage and need for stone-related surgical intervention...
April 19, 2018: BJU International
https://www.readbyqxmd.com/read/29675895/at-vessel-mortality-of-skates-rajidae-taken-in-coastal-fisheries-and-evidence-of-longer-term-survival
#10
J R Ellis, G J Burt, G Grilli, S R McCully Phillips, T L Catchpole, D L Maxwell
Data on the vigour and at-vessel mortality (AVM) of 6798 skates (comprising Raja clavata n = 6295; R. brachyura n = 208; R. undulata n = 185, R. montagui n = 98 and R. microocellata n = 12) captured by commercial fishing vessels in the inshore waters of the southern North Sea and English Channel were recorded. AVM in longline fisheries averaged 0·44% across five vessels (0-1·47%), although skates were usually unhooked manually and did not usually pass through a bait-stripper. AVM in otter trawls averaged 0·76% (0-2·35%), from four vessels fishing with tow durations of <1·5 h (southern North Sea) or 1-4 h (English Channel)...
April 19, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29675327/observation-of-laser-induced-elastic-waves-in-agar-skin-phantoms-using-a-high-speed-camera-and-a-laser-beam-deflection-probe
#11
Jernej Laloš, Peter Gregorčič, Matija Jezeršek
We present an optical study of elastic wave propagation inside skin phantoms consisting of agar gel as induced by an Er:YAG (wavelength of 2.94 μm) laser pulse. A laser-beam-deflection probe is used to measure ultrasonic propagation and a high-speed camera is used to record displacements in ablation-induced elastic transients. These measurements are further analyzed with a custom developed image recognition algorithm utilizing the methods of particle image velocimetry and spline interpolation to determine point trajectories, material displacement and strain during the passing of the transients...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29674998/distributions-and-abundances-of-sublineages-of-the-n-2-fixing-cyanobacterium-candidatus-atelocyanobacterium-thalassa-ucyn-a-in-the-new-caledonian-coral-lagoon
#12
Britt A Henke, Kendra A Turk-Kubo, Sophie Bonnet, Jonathan P Zehr
Nitrogen (N2 ) fixation is a major source of nitrogen that supports primary production in the vast oligotrophic areas of the world's oceans. The Western Tropical South Pacific has recently been identified as a hotspot for N2 fixation. In the Noumea lagoon (New Caledonia), high abundances of the unicellular N2 -fixing cyanobacteria group A (UCYN-A), coupled with daytime N2 fixation rates associated with the <10 μm size fraction, suggest UCYN-A may be an important diazotroph (N2 -fixer) in this region. However, little is known about the seasonal variability and diversity of UCYN-A there...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674961/unsupervised-feature-learning-with-winner-takes-all-based-stdp
#13
Paul Ferré, Franck Mamalet, Simon J Thorpe
We present a novel strategy for unsupervised feature learning in image applications inspired by the Spike-Timing-Dependent-Plasticity (STDP) biological learning rule. We show equivalence between rank order coding Leaky-Integrate-and-Fire neurons and ReLU artificial neurons when applied to non-temporal data. We apply this to images using rank-order coding, which allows us to perform a full network simulation with a single feed-forward pass using GPU hardware. Next we introduce a binary STDP learning rule compatible with training on batches of images...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29674365/protocol-of-a-multicenter-international-randomized-controlled-manikin-study-on-different-protocols-of-cardiopulmonary-resuscitation-for-laypeople-mani-cpr
#14
Enrico Baldi, Enrico Contri, Roman Burkart, Paola Borrelli, Ottavia Eleonora Ferraro, Michela Tonani, Amedeo Cutuli, Daniele Bertaia, Pasquale Iozzo, Caroline Tinguely, Daniel Lopez, Susi Boldarin, Claudio Deiuri, Sandrine Dénéréaz, Yves Dénéréaz, Michael Terrapon, Christian Tami, Cinzia Cereda, Alberto Somaschini, Stefano Cornara, Andrea Cortegiani
INTRODUCTION: Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674258/does-the-public-s-negative-perception-towards-wood-in-rivers-relate-to-recent-impact-of-flooding-experiencing
#15
Virginia Ruiz-Villanueva, Andrés Díez-Herrero, Juan Antonio García, Alfredo Ollero, Hervé Piégay, Markus Stoffel
Instream large wood (LW) is widely perceived as a source of hazard that should be avoided. This is also the case of Spain, where wood has been systematically removed from rivers for decades. Consequently, people are accustomed to rivers with minimal or no LW at all. However, the presence and transport of wood is natural and has positive ecological effects. Previous studies reported that the general negative perception towards LW in rivers is related to the lack of background knowledge about stream ecology or fluvial dynamics...
April 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29674251/outpatient-transition-to-extended-release-injectable-naltrexone-for-patients-with-opioid-use-disorder-a-phase-3-randomized-trial
#16
Adam Bisaga, Paolo Mannelli, Miao Yu, Narinder Nangia, Christine E Graham, D Andrew Tompkins, Thomas R Kosten, Sarah C Akerman, Bernard L Silverman, Maria A Sullivan
BACKGROUND: Injectable extended-release naltrexone (XR-NTX), approved to prevent relapse to opioid dependence, requires initial abstinence. This multisite outpatient clinical trial examined the efficacy and safety of low-dose oral naltrexone (NTX), combined with a brief buprenorphine (BUP) taper and standing ancillary medications, for detoxification and induction onto XR-NTX. METHODS: Patients (N = 378) were randomized, stratified by primary short-acting opioid-of-use, to one of three regimens: NTX + BUP; NTX + placebo BUP (PBO-B); placebo NTX (PBO-N) + PBO-B...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29674096/kinetic-analysis-of-retention-of-so-2-using-waste-ulexite-ore-in-an-aqueous-medium
#17
Özlem Karagöz, Mehmet Çopur, M Muhtar Kocakerim
This study was carried out under atmospheric pressure and examined the kinetics of retention of SO2 , a toxic gas, by waste ulexite ore (WUO) from a boron concentration plant, as well as the kinetics of passing B2 O3 content of WUO to solution. The parameters of temperature, solid-to-liquid ratio, particle size, gas flow rate, and stirring speed were selected for the experiments carried out in a jacketted cylindirical glass reactor. The data on retention-dissolution and an XRD graph showed that SO2 had been captured as CaSO3 ·0...
April 4, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29674084/development-of-a-plug-type-ims-ms-instrument-and-its-applications-in-resolving-problems-existing-in-in-situ-detection-of-illicit-drugs-and-explosives-by-ims
#18
Zhenxia Du, Tangqiang Sun, Jianan Zhao, Di Wang, Zhongxia Zhang, Wenlian Yu
Ion mobility spectrometry (IMS) which acts as a rapid analysis technique is widely used in the field detection of illicit drugs and explosives. Due to limited separation abilities of the pint-sized IMS challenges and problems still exist regarding high false positive and false negative responses due to the interference of the matrix. In addition, the gas-phase ion chemistry and special phenomena in the IMS spectra, such one substance showing two peaks, were not identified unambiguously. In order to explain or resolve these questions, in this paper, an ion mobility spectrometry was coupled to a mass spectrometry (IMS-MS)...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673249/tracing-the-fate-of-atmospheric-nitrate-in-a-subalpine-watershed-using-%C3%AE-17-o
#19
Ilann Bourgeois, Joël Savarino, Nicolas Caillon, Helene Angot, Albane Barbero, Franck Delbart, Didier Voisin, Jean-Christophe Clement
Nitrogen is an essential nutrient for life on Earth, but in excess, it can lead to environmental issues (e.g., N saturation, loss of biodiversity, acidification of lakes, etc.). Understanding the nitrogen budget (i.e., inputs and outputs) is essential to evaluate the prospective decay of the ecosystem services (e.g., freshwater quality, erosion control, loss of high patrimonial-value plant species, etc.) that subalpine headwater catchments provide, especially as these ecosystems experience high atmospheric nitrogen deposition...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29672147/suicide-prevention-training-policies-for-health-care-professionals-across-the-united-states-as-of-october-2017
#20
Janessa M Graves, Jessica L Mackelprang, Sara E Van Natta, Carrie Holliday
OBJECTIVES: To identify and compare state policies for suicide prevention training among health care professionals across the United States and benchmark state plan updates against national recommendations set by the surgeon general and the National Action Alliance for Suicide Prevention in 2012. METHODS: We searched state legislation databases to identify policies, which we described and characterized by date of adoption, target audience, and duration and frequency of the training...
April 19, 2018: American Journal of Public Health
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