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https://www.readbyqxmd.com/read/27908811/decreased-serum-levels-of-high-mobility-group-box-1-hmgb-1-after-graft-replacement-or-stenting-of-abdominal-aortic-aneurysm
#1
Daiki Ousaka, Yasuhiro Fujii, Susumu Oozawa, Masahiro Nishibori, Yosuke Kuroko, Zenichi Masuda, Shunji Sano
OBJECTIVES: High-mobility group box 1 (HMGB-1) is a key substance mediating inflammation and development of atherosclerotic lesions (AL), including abdominal aortic aneurysms (AAA). Serum levels of HMGB-1 are increased in patients with AAA than in normal controls because the ALs in AAAs secrete HMGB-1. We therefore postulate that the serum HMGB-1 level should decrease after endovascular aortic repair (EVAR) or open aortic repair (OAR). However, there is no evidence of this in the literature...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27903656/yeast-hmo1-linker-histone-reinvented
#2
REVIEW
Arvind Panday, Anne Grove
Eukaryotic genomes are packaged in chromatin. The higher-order organization of nucleosome core particles is controlled by the association of the intervening linker DNA with either the linker histone H1 or high mobility group box (HMGB) proteins. While H1 is thought to stabilize the nucleosome by preventing DNA unwrapping, the DNA bending imposed by HMGB may propagate to the nucleosome to destabilize chromatin. For metazoan H1, chromatin compaction requires its lysine-rich C-terminal domain, a domain that is buried between globular domains in the previously characterized yeast Saccharomyces cerevisiae linker histone Hho1p...
March 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/27872202/genome-wide-overexpression-screen-identifies-genes-able-to-bypass-p16-mediated-senescence-in-melanoma
#3
Won Jae Lee, Dubravka Škalamera, Mareike Dahmer-Heath, Konstanin Shakhbazov, Max V Ranall, Carly Fox, Duncan Lambie, Alexander J Stevenson, Paul Yaswen, Thomas J Gonda, Brian Gabrielli
Malignant melanomas often arise from nevi, which result from initial oncogene-induced hyperproliferation of melanocytes that are maintained in a CDKN2A/p16-mediated senescent state. Thus, genes that can bypass this senescence barrier are likely to contribute to melanoma development. We have performed a gain-of-function screen of 17,030 lentivirally expressed human open reading frames (ORFs) in a melanoma cell line containing an inducible p16 construct to identify such genes. Genes known to bypass p16-induced senescence arrest, including the human papilloma virus 18 E7 gene (HPV18E7), and genes such as the p16-binding CDK6 with expected functions, as well as panel of novel genes, were identified, including high-mobility group box (HMGB) proteins...
November 21, 2016: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/27869797/the-receptor-for-advanced-glycation-end-products-impairs-collateral-formation-in-both-diabetic-and-non-diabetic-mice
#4
Laura M Hansen, Divya Gupta, Giji Joseph, Daiana Weiss, W Robert Taylor
Diabetics often have poor perfusion in their limbs as a result of peripheral artery disease and an impaired ability to generate collateral vessels. The receptor for advanced glycation end products (RAGE) is one protein that is thought to play a detrimental role in collateral development in diabetics due to increased levels of advanced glycation end products (AGE), one of its ligands, in diabetes. Thus, the aim of this study was to investigate the role of RAGE in both diabetic and non-diabetic settings in a model of collateral formation in mice...
November 21, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27860296/impact-of-subnormothermic-machine-perfusion-preservation-in-severely-steatotic-rat-livers-a-detailed-assessment-in-an-isolated-setting
#5
Y Okamura, K Hata, H Tanaka, H Hirao, T Kubota, O Inamoto, S Kageyama, I Tamaki, N Yermek, J Yoshikawa, S Uemoto
Current drastic shortage of donor organs has led to acceptance of extended-criteria donors for transplantation, despite higher risk of primary non-function. Here, we report the impact of subnormothermic machine perfusion (SMP) preservation on the protection of >50% macro-steatotic livers. Dietary hepatic steatosis was induced in Wistar rats via 2-day fasting and subsequent 3-day re-feeding with a fat-free, carbohydrate-rich diet. This protocol induces 50-60% macrovesicular steatosis, which should be discarded when preserved via cold storage (CS)...
November 10, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27860073/oligomerization-of-hmo1-mediated-by-box-a-is-essential-for-dna-binding-in%C3%A2-vitro-and-in%C3%A2-vivo
#6
Koji Kasahara, Ayako Higashino, Satoru Unzai, Hirofumi Yoshikawa, Tetsuro Kokubo
Hmo1, a member of HMGB family proteins in Saccharomyces cerevisiae, binds to and regulates the transcription of genes encoding ribosomal RNA and ribosomal proteins. The functional motifs of Hmo1 include two HMG-like motifs, box A and box B, and a C-terminal tail. To elucidate the molecular roles of the HMG-like boxes in DNA binding in vivo, we analyzed the DNA-binding activity of various Hmo1 mutants using ChIP or reporter assays that enabled us to conveniently detect Hmo1 binding to the promoter of RPS5, a major target gene of Hmo1...
November 15, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27847406/high-mobility-group-box-1-a-missing-link-between-diabetes-and-its-complications
#7
REVIEW
Han Wu, Zheng Chen, Jun Xie, Li-Na Kang, Lian Wang, Biao Xu
High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflammation, in addition to its role in progression of diabetes, also promotes initiation and development of diabetic complications. In this review, we focus on the role of HMGB-1 in diabetes-related complications and the therapeutic strategies targeting HMGB-1 in diabetic complications...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27833703/reduced-hmgb-1-mediated-pathway-and-oxidative-stress-in-resveratrol-treated-diabetic-mice-a-possible-mechanism-of-cardioprotection-of-resveratrol-in-diabetes-mellitus
#8
Han Wu, Zhen-Qiang Sheng, Jun Xie, Ran Li, Liang Chen, Guan-Nan Li, Lian Wang, Biao Xu
Myocardial fibrosis and inflammation are intricately linked in diabetic cardiomyopathy (DCM), and resveratrol has been shown to attenuate oxidative stress, inflammation, and fibrosis in several cell types or animal models. High mobility group box 1 (HMGB 1), a proinflammatory cytokine, has been reported to regulate fibrosis and inflammation in various organs. Then the present study aimed to reveal the expression of HMGB 1-mediated signaling pathway and oxidative stress in resveratrol-treated diabetic mice. The significant increase in serum HMGB 1 concentration in diabetic mice was attenuated by treatment with resveratrol...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27804999/overexpression-of-soluble-rage-in-mesenchymal-stem-cells-enhances-their-immunoregulatory-potential-for-cellular-therapy-in-autoimmune-arthritis
#9
Min-Jung Park, Seung Hoon Lee, Su-Jin Moon, Jung-Ah Lee, Eun-Jung Lee, Eun-Kyung Kim, Jin-Sil Park, Jennifer Lee, Jun-Ki Min, Seok Jung Kim, Sung-Hwan Park, Mi-La Cho
Mesenchymal stem cells (MSCs) are attractive agents for cellular therapy in rheumatoid arthritis (RA). The receptor for advanced glycation end products (RAGE) serves as a pattern recognition receptor for endogenous inflammatory ligands. Soluble RAGE (sRAGE) is a truncated form of RAGE that functions as a decoy and acts as an anti-inflammatory molecule. The aim of this study was to determine whether sRAGE has therapeutic effects and the mechanisms active in sRAGE-overexpressing MSCs (sRAGE-MSCs) in an experimental model of RA...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27796342/single-multiplex-detection-of-organ-injury-biomarkers-using-spri-based-nano-immunosensor
#10
Effat Zeidan, Siqi Li, Zhiguo Zhou, Jennifer Miller, Marinella G Sandros
The clinical assessment of multiple organ dysfunctions at early stages is recognized to be an important factor in prompting definitive treatment decisions that prevent irreversible organ damage. In this article, we propose a real-time, label-free, and multiplex nanoenhanced SPRi platform to quantitatively assess two biomarkers, kidney injury molecule (KIM-1) and high mobility group box-1 (HMGB-1) simultaneously in buffer. Our work involves three major contributions in the design of the immunosensor: (1) we applied site-specific immobilization of antibodies to the solid surface that avoids loss of biological activity caused by covalent attachment; (2) we constructed a well-blocked sensor surface that exhibits minimal non-specific adsorption for singleplex measurements of each biomarker in buffer; and (3) we adopted a sandwich assay that implements functionalized quantum dots (NanoEnhancers) as signal amplifiers to achieve a sensitivity level of 5 pg/mL for KIM-1 and HMGB-1 in buffer...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27792788/trem-1-hmgb1-and-rage-in-the-shoulder-tendon-dual-mechanisms-for-inflammation-based-on-the-coincidence-of-glenohumeral-arthritis
#11
Finosh G Thankam, Matthew F Dilisio, Nicholas E Dietz, Devendra K Agrawal
Rotator cuff injury (RCI) is a major musculoskeletal disorder in the adult population where inflammation and pain are major contributing factors. Coincidence of other clinical conditions like glenohumeral arthritis aggravates inflammation and delays the healing response. The mechanism and signaling factors underlying the sustenance of inflammation in the rotator cuff joint are largely unknown. The present article aims to elucidate the involvement of inflammatory molecule, TREM-1 (Triggering Receptors Expressed on Myeloid cells-1), and danger-associated molecular patterns (DAMPs), including high mobility group protein 1 (HMGB-1) and RAGE (receptor for advanced glycation end products), in the setting of RCI with respect to the severity of glenohumeral arthritis...
2016: PloS One
https://www.readbyqxmd.com/read/27738641/plasma-c1q-tnf-related-protein-3-ctrp-3-and-high-mobility-group-box-1-hmgb-1-concentrations-in-subjects-with-prediabetes-and-type-2-diabetes
#12
Huili Wei, Hua Qu, Hang Wang, Huacong Deng
Aims. To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM). Methods. 224 eligible participants were included. The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured. All participants were divided into three groups: normal glucose tolerance (NGT, n = 62), pre-DM (n = 111), and nT2DM group (n = 56). Results...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27725858/microrna-218-modulates-activities-of-glioma-cells-by-targeting-hmgb1
#13
Jianjun Gu, Rong Xu, Yaxing Li, Jianhe Zhang, Shousen Wang
To explore the effects of microRNA-218 (miR-218) on glioma cell lines and the related mechanism. U251 and U87 cells were transfected with negative control, miR-218 mimic or miR-218 inhibitor using lipofectamine 2000. The expressions of mRNA and proteins were detected with qRT-PCR and Western blotting. The cell proliferation, apoptosis, migration and invasion were studied using MTT, flow cytometry, Transwell assay and scratch-wound assay, respectively. The targeting effect of HMGB1 by miR-218 was measured with luciferase reporter assay...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27682500/-the-wle-of-high-mobility-group-protein-b1-hmgb-1-on-inflammatony-responese-and-pulmonary-fibrosis-induced-by-silica-dusty
#14
J X Ma, M Zhou, L L Xiao
No abstract text is available yet for this article.
July 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27676640/ethanol-and-high-cholesterol-diet-causes-severe-steatohepatitis-and-early-liver-fibrosis-in-mice
#15
Yasodha Krishnasamy, Venkat K Ramshesh, Monika Gooz, Rick G Schnellmann, John J Lemasters, Zhi Zhong
BACKGROUND AND AIM: Because ethanol consumption is commonly associated with a high cholesterol diet, we examined whether combined consumption of ethanol and high cholesterol increases liver injury and fibrosis. METHODS: Male C57BL/6J mice were fed diets containing: 1) 35% of calories from corn oil (CTR), 2) CTR plus 0.5% (w/v) cholesterol (Chol), 3) CTR plus ethanol (27% of calories) (EtOH), or 4) EtOH+Chol for 3 months. RESULTS: In mice fed Chol or EtOH alone, ALT increased to ~160 U/L, moderate hepatic steatosis occurred, and leukocyte infiltration, necrosis, and apoptosis increased modestly, but no observable fibrosis developed...
2016: PloS One
https://www.readbyqxmd.com/read/27647532/ds-hmgb1-and-fr-hmgb-induce-depressive-behavior-through-neuroinflammation-in-contrast-to-nonoxid-hmgb1
#16
Yong-Jie Lian, Hong Gong, Teng-Yun Wu, Wen-Jun Su, Yi Zhang, Yuan-Yuan Yang, Wei Peng, Ting Zhang, Jiang-Rui Zhou, Chun-Lei Jiang, Yun-Xia Wang
High mobility group box 1 (HMGB1) has been implicated as a key factor in several neuroinflammatory conditions. Our previous study suggested that the release of central HMGB1 acts as a late-phase mediator in lipopolysaccharide (LPS)-induced depression. Recent findings indicate that the redox state of HMGB1 is a critical determinant of its immunomodulatory properties. Here, we aimed to investigate the potential mechanisms that link the redox states of HMGB1 to depression in mice. Distinct redox forms of recombinant HMGB1 (rHMGB1) were used that included fully reduced HMGB (fr-HMGB1), which acted as a chemokine, and disulfide-HMGB1 (ds-HMGB1), which possessed cytokine activity...
September 16, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27608812/hmgb4-is-expressed-by-neuronal-cells-and-affects-the-expression-of-genes-involved-in-neural-differentiation
#17
Ari Rouhiainen, Xiang Zhao, Päivi Vanttola, Kui Qian, Evgeny Kulesskiy, Juha Kuja-Panula, Kathleen Gransalke, Mikaela Grönholm, Emmanual Unni, Marvin Meistrich, Li Tian, Petri Auvinen, Heikki Rauvala
HMGB4 is a new member in the family of HMGB proteins that has been characterized in sperm cells, but little is known about its functions in somatic cells. Here we show that HMGB4 and the highly similar rat Transition Protein 4 (HMGB4L1) are expressed in neuronal cells. Both proteins had slow mobility in nucleus of living NIH-3T3 cells. They interacted with histones and their differential expression in transformed cells of the nervous system altered the post-translational modification statuses of histones in vitro...
September 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27591276/effect-of-alpha-lipoic-acid-on-relieving-ammonia-stress-and-hepatic-proteomic-analyses-of-broilers
#18
M Lu, J Bai, B Xu, Q Y Sun, F X Wei, X F Tang, H F Zhang, J Li, G L Wang, Q Q Yin, S Y Li
Ammonia in poultry houses not only affects worker health but also induces a variety of poultry diseases. Alpha-lipoic acid (LA) is an effective antioxidant that protects cells against oxidative injury during various toxic and pathological processes. This study was designed to evaluate the mitigating effects of LA supplementation on ammonia stress and hepatic proteome changes in broilers. Male broilers (22 d old) were allocated to 3 groups: (1) a control group without ammonia stress (CTRL); (2) exposure to 70 ppm ammonia (AM); and (3) exposure to 70 ppm ammonia and dietary administration of 300 mg/kg LA (AM+LA)...
September 2, 2016: Poultry Science
https://www.readbyqxmd.com/read/27567422/effects-of-insulin-combined-with-ethyl-pyruvate-on-inflammatory-response-and-oxidative-stress-in-multiple-organ-dysfunction-syndrome-rats-with-severe-burns
#19
Zhanke Wang, Rongjian Chen, Zhongzhen Zhu, Xiaoyun Zhang, Shiliang Wang
BACKGROUND: Inflammation response and oxidative stress promote the occurrence and development of multiple-organ dysfunction syndrome (MODS). METHODS: Eighty MODS rats with third-degree burns were divided randomly into 4 groups: insulin, ethyl pyruvate (EP), insulin combined with EP, and control. Blood levels of glucose, alanine aminotransferase (ALT), creatine (CRE), creatine kinase (CK), tumor necrosis factor α (TNF-α), high-mobility group box 1 (HMGB-1), malondialdehyde (MDA), and total antioxidant capacity (TAC) before as well as 1, 3, 5, and 7 days after burns were measured...
August 9, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27562050/-protective-effects-of-oxycodone-on-lipopolysaccharide-induced-acute-lung-injury-in-rats
#20
B Yang, W D Zhang, Y M Xia, Z P Zhang, L Li, L Zhang, W C Wang, Z D Wang, X P Li
OBJECTIVE: To analyze the role of oxycodone in acute lung injury(ALI) induced by lipopolysaccharide (LPS) in rats. METHODS: Male SD rats were randomly allocated into 4 groups: control group, oxycodone group, LPS group, LPS+ oxycodone group. The effects of oxycodone on LPS-induced neutrophils influx, inflammatory cytokines release, pulmonary edema, apoptotic cell were examined. In addition, the toll-like receptor 4 (TLR4) in lung tissues was detected by Western blotting...
August 16, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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