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https://www.readbyqxmd.com/read/28336800/the-ethics-of-big-data-as-a-public-good-which-public-whose-good
#1
Linnet Taylor
International development and humanitarian organizations are increasingly calling for digital data to be treated as a public good because of its value in supplementing scarce national statistics and informing interventions, including in emergencies. In response to this claim, a 'responsible data' movement has evolved to discuss guidelines and frameworks that will establish ethical principles for data sharing. However, this movement is not gaining traction with those who hold the highest-value data, particularly mobile network operators who are proving reluctant to make data collected in low- and middle-income countries accessible through intermediaries...
December 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28336792/data-philanthropy-and-the-design-of-the-infraethics-for-information-societies
#2
Mariarosaria Taddeo
In mature information societies, sharing data is increasingly recognized as a crucial means to foster their development. However, competing tensions on data control and ownership, limited technical understanding, and the lack of an adequate governance framework pose serious challenges to attempts to share data among different actors. Data philanthropy, understood as the donation of data from both individuals and private companies, has been proposed as means to meet these challenges. While at first sight data philanthropy may seem an uncontroversial phenomenon, a closer analysis reveals a bewildering network of problems...
December 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28334748/the-shifting-dynamics-of-social-roles-and-project-ownership-over-the-lifecycle-of-a-community-based-participatory-research-project
#3
Jon Salsberg, Soultana Macridis, Enrique Garcia Bengoechea, Ann C Macaulay, Spencer Moore
Background: . Community based participatory research (CBPR) is often initiated by academic researchers, yet relies on meaningful community engagement and ownership to have lasting impact. Little is understood about how ownership shifts from academic to community partners. Objectives: . We examined a CBPR project over its life course and asked: what does the evolution of ownership look like from project initiation by an academic (non-community) champion (T1); to maturation-when the intervention is ready to be deployed (T2); to independence-the time when the original champion steps aside (T3); and finally, to its maintenance-when the community has had an opportunity to function independently of the original academic champion (T4)? Methods: ...
February 21, 2017: Family Practice
https://www.readbyqxmd.com/read/28327150/research-impact-of-systems-level-long-term-care-research-a-multiple-case-study
#4
Anita Kothari, Nedra Peter, Melissa Donskov, Tracy Luciani
BACKGROUND: Traditional reporting of research outcomes and impacts, which tends to focus on research product publications and grant success, does not capture the value, some contributions, or the complexity of research projects. The purpose of this study was to understand the contributions of five systems-level research projects as they were unfolding at the Bruyère Centre for Learning, Research and Innovation (CLRI) in long-term care (LTC) in Ottawa, Ontario, Canada. The research questions were, (1) How are partnerships with research end-users (policymakers, administrators and other public/private organisations) characterised? (2) How have interactions with the CLRI Management Committee and Steering Committee influenced the development of research products? (3) In what way have other activities, processes, unlinked actors or organisations been influenced by the research project activities? METHODS: The study was guided by Kok and Schuit's concept of research impacts, using a multiple case study design...
March 21, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28326307/p75-neurotrophin-receptor-in-the-skin-beyond-its-neurotrophic-function
#5
REVIEW
Carlo Pincelli
p75 neurotrophin receptor (p75(NTR)), also known as CD271, is the low-affinity receptor that, together with the tyrosine kinase receptor tropomyosin-receptor kinase (Trk), mediate neurotrophin (NT) functions. Beside their classic role in skin innervation, NT and their receptors constitute a complex cutaneous network associated with a number of autocrine and paracrine activities. In this context, the role of p75(NTR) is becoming more and more important. This review will focus on the intriguing functions of p75(NTR) in healthy and diseased skin...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28298209/implementation-of-evidence-informed-practice-through-central-network-actors-a-case-study-of-three-public-health-units-in-canada
#6
Reza Yousefi Nooraie, Alexandra Marin, Robert Hanneman, Lynne Lohfeld, Maureen Dobbins
BACKGROUND: Workforce development is an important aspect of evidence-informed decision making (EIDM) interventions. The social position of individuals in formal and informal social networks, and the relevance of formal roles in relation to EIDM are important factors identifying key EIDM players in public health organizations. We assessed the role of central actors in information sharing networks in promoting the adoption of EIDM by the staff of three public health units in Canada, over a two-year period during which an organization-wide intervention was implemented...
March 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28289044/exploiting-social-influence-to-magnify-population-level-behaviour-change-in-maternal-and-child-health-study-protocol-for-a-randomised-controlled-trial-of-network-targeting-algorithms-in-rural-honduras
#7
Holly B Shakya, Derek Stafford, D Alex Hughes, Thomas Keegan, Rennie Negron, Jai Broome, Mark McKnight, Liza Nicoll, Jennifer Nelson, Emma Iriarte, Maria Ordonez, Edo Airoldi, James H Fowler, Nicholas A Christakis
INTRODUCTION: Despite global progress on many measures of child health, rates of neonatal mortality remain high in the developing world. Evidence suggests that substantial improvements can be achieved with simple, low-cost interventions within family and community settings, particularly those designed to change knowledge and behaviour at the community level. Using social network analysis to identify structurally influential community members and then targeting them for intervention shows promise for the implementation of sustainable community-wide behaviour change...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28277703/network-behavior-dynamics-of-adolescent-friendships-alcohol-use-and-physical-activity
#8
Emily Long, Tyson S Barrett, Ginger Lockhart
OBJECTIVE: The coevolution of adolescent social networks, alcohol use, and physical activity is studied. Previous research has independently evaluated each behavior, overlooking the potential power of examining their development within a shared social context. The current study extends previous research by examining the dynamics of friendship networks, alcohol use, and physical activity in conjunction, including the concurrent engagement in both behaviors, with a nationally representative sample of U...
March 9, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28275850/analysis-of-swedish-forest-owners-information-and-knowledge-sharing-networks-for-decision-making-insights-for-climate-change-communication-and-adaptation
#9
Karin André, Julia Baird, Åsa Gerger Swartling, Gregor Vulturius, Ryan Plummer
To further the understanding of climate change adaptation processes, more attention needs to be paid to the various contextual factors that shape whether and how climate-related knowledge and information is received and acted upon by actors involved. This study sets out to examine the characteristics of forest owners' in Sweden, the information and knowledge-sharing networks they draw upon for decision-making, and their perceptions of climate risks, their forests' resilience, the need for adaptation, and perceived adaptive capacity...
March 8, 2017: Environmental Management
https://www.readbyqxmd.com/read/28254507/primary-somatosensory-cortex-necessary-for-the-perception-of-weight-from-other-people-s-action-a-continuous-theta-burst-tms-experiment
#10
Nikola Valchev, Emmanuele Tidoni, Antonia F de C Hamilton, Valeria Gazzola, Alessio Avenanti
The presence of a network of areas in the parietal and premotor cortices, which are active both during action execution and observation, suggests that we might understand the actions of other people by activating those motor programs for making similar actions. Although neurophysiological and imaging studies show an involvement of the somatosensory cortex (SI) during action observation and execution, it is unclear whether SI is essential for understanding the somatosensory aspects of observed actions. To address this issue, we used off-line transcranial magnetic continuous theta-burst stimulation (cTBS) just before a weight judgment task...
February 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/28238198/the-social-historical-and-institutional-contingencies-of-dam-removal
#11
F J Magilligan, C S Sneddon, C A Fox
Environmental managers in the United States and elsewhere are increasingly perceiving dam removal as a critical tool for river restoration and enhancing watershed resilience. In New England, over 125 dams have been dismantled for ecological and economic rationales. A surprising number of these removals, including many that are ongoing, have generated heated conflicts between restoration proponents and local communities who value their dammed landscapes. Using a comparative case study approach, we examine the environmental conflict around efforts to remove six dams in New England...
February 25, 2017: Environmental Management
https://www.readbyqxmd.com/read/28226043/support-to-woman-nourisher-in-the-advertising-pieces-of-the-world-breastfeeding-week
#12
Luciana Alves Moreira, Nina Velasco E Cruz, Francisca Marcia Pereira Linhares, Tatiane Gomes Guedes, Fernanda Demutti Pimpão Martins, Cleide Maria Pontes
Objective: to unveil the support to woman/nourisher in the advertisements of the World Breastfeeding Week. Method: This is a descriptive, exploratory, documentary, qualitative study. Since the collection until the analyses of these advertisements, we adopted the methodological steps of Gemma Penn, based on the semiology of Roland Barthes. The results were interpreted by the theory of Social Network of Sanícola and of the five types of support: companionship, emotional, instrumental, informational, and self-supportive...
January 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28213340/demographic-and-indication-specific-characteristics-have-limited-association-with-social-network-engagement-evidence-from-24-954-members-of-four-health-care-support-groups
#13
Trevor van Mierlo, Xinlong Li, Douglas Hyatt, Andrew T Ching
BACKGROUND: Digital health social networks (DHSNs) are widespread, and the consensus is that they contribute to wellness by offering social support and knowledge sharing. The success of a DHSN is based on the number of participants and their consistent creation of externalities through the generation of new content. To promote network growth, it would be helpful to identify characteristics of superusers or actors who create value by generating positive network externalities. OBJECTIVE: The aim of the study was to investigate the feasibility of developing predictive models that identify potential superusers in real time...
February 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28208755/micrornas-new-insight-in-modulating-follicular-atresia-a-review
#14
REVIEW
Tesfaye Worku, Zia Ur Rehman, Hira Sajjad Talpur, Dinesh Bhattarai, Farman Ullah, Ngabu Malobi, Tesfaye Kebede, Liguo Yang
Our understanding of the post-transcriptional mechanisms involved in follicular atresia is limited; however, an important development has been made in understanding the biological regulatory networks responsible for mediating follicular atresia. MicroRNAs have come to be seen as a key regulatory actor in determining cell fate in a wide range of tissues in normal and pathological processes. Profiling studies of miRNAs during follicular atresia and development have identified several putative miRNAs enriched in apoptosis signaling pathways...
February 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28208447/influence-of-trust-in-the-spreading-of-information
#15
Hongrun Wu, Alex Arenas, Sergio Gómez
The understanding and prediction of information diffusion processes on networks is a major challenge in network theory with many implications in social sciences. Many theoretical advances occurred due to stochastic spreading models. Nevertheless, these stochastic models overlooked the influence of rational decisions on the outcome of the process. For instance, different levels of trust in acquaintances do play a role in information spreading, and actors may change their spreading decisions during the information diffusion process accordingly...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28187158/role-of-the-long-non-coding-rna-pvt1-in-the-dysregulation-of-the-cerna-cerna-network-in-human-breast-cancer
#16
Federica Conte, Giulia Fiscon, Matteo Chiara, Teresa Colombo, Lorenzo Farina, Paola Paci
Recent findings have identified competing endogenous RNAs (ceRNAs) as the drivers in many disease conditions, including cancers. The ceRNAs indirectly regulate each other by reducing the amount of microRNAs (miRNAs) available to target messenger RNAs (mRNAs). The ceRNA interactions mediated by miRNAs are modulated by a titration mechanism, i.e. large changes in the ceRNA expression levels either overcome, or relieve, the miRNA repression on competing RNAs; similarly, a very large miRNA overexpression may abolish competition...
2017: PloS One
https://www.readbyqxmd.com/read/28166508/quantization-based-adaptive-actor-critic-tracking-control-with-tracking-error-constraints
#17
Quan-Yong Fan, Guang-Hong Yang, Dan Ye
In this paper, the problem of adaptive actor-critic (AC) tracking control is investigated for a class of continuous-time nonlinear systems with unknown nonlinearities and quantized inputs. Different from the existing results based on reinforcement learning, the tracking error constraints are considered and new critic functions are constructed to improve the performance further. To ensure that the tracking errors keep within the predefined time-varying boundaries, a tracking error transformation technique is used to constitute an augmented error system...
February 1, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28166226/social-network-analysis-of-multi-stakeholder-platforms-in-agricultural-research-for-development-opportunities-and-constraints-for-innovation-and-scaling
#18
Frans Hermans, Murat Sartas, Boudy van Schagen, Piet van Asten, Marc Schut
Multi-stakeholder platforms (MSPs) are seen as a promising vehicle to achieve agricultural development impacts. By increasing collaboration, exchange of knowledge and influence mediation among farmers, researchers and other stakeholders, MSPs supposedly enhance their 'capacity to innovate' and contribute to the 'scaling of innovations'. The objective of this paper is to explore the capacity to innovate and scaling potential of three MSPs in Burundi, Rwanda and the South Kivu province located in the eastern part of Democratic Republic of Congo (DRC)...
2017: PloS One
https://www.readbyqxmd.com/read/28152422/street-level-diplomacy-communicative-and-adaptive-work-at-the-front-line-of-implementing-public-health-policies-in-primary-care
#19
Nicola Gale, George Dowswell, Sheila Greenfield, Tom Marshall
Public services are increasingly operating through network governance, requiring those at all levels of the system to build collaborations and adapt their practice. Agent-focused implementation theories, such as 'street-level bureaucracy', tend to focus on decision-making and the potential of actors to subvert national policy at a local level. While it is acknowledged that network leaders need to be adaptable and to build trust, much less consideration has been given to the requirement for skills of 'diplomacy' needed by those at the front line of delivering public services...
January 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28134793/trm112-a-protein-activator-of-methyltransferases-modifying-actors-of-the-eukaryotic-translational-apparatus
#20
REVIEW
Gabrielle Bourgeois, Juliette Létoquart, Nhan van Tran, Marc Graille
Post-transcriptional and post-translational modifications are very important for the control and optimal efficiency of messenger RNA (mRNA) translation. Among these, methylation is the most widespread modification, as it is found in all domains of life. These methyl groups can be grafted either on nucleic acids (transfer RNA (tRNA), ribosomal RNA (rRNA), mRNA, etc.) or on protein translation factors. This review focuses on Trm112, a small protein interacting with and activating at least four different eukaryotic methyltransferase (MTase) enzymes modifying factors involved in translation...
January 27, 2017: Biomolecules
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