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https://www.readbyqxmd.com/read/28721199/evidence-informed-capacity-building-for-setting-health-priorities-in-low-and-middle-income-countries-a-framework-and-recommendations-for-further-research
#1
Ryan Li, Francis Ruiz, Anthony J Culyer, Kalipso Chalkidou, Karen J Hofman
Priority-setting in health is risky and challenging, particularly in resource-constrained settings. It is not simply a narrow technical exercise, and involves the mobilisation of a wide range of capacities among stakeholders - not only the technical capacity to "do" research in economic evaluations. Using the Individuals, Nodes, Networks and Environment (INNE) framework, we identify those stakeholders, whose capacity needs will vary along the evidence-to-policy continuum. Policymakers and healthcare managers require the capacity to commission and use relevant evidence (including evidence of clinical and cost-effectiveness, and of social values); academics need to understand and respond to decision-makers' needs to produce relevant research...
2017: F1000Research
https://www.readbyqxmd.com/read/28718405/rna-binding-proteins-in-cancer-old-players-and-new-actors
#2
REVIEW
Bruno Pereira, Marc Billaud, Raquel Almeida
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The combination of versatility of their RNA-binding domains with structural flexibility enables RBPs to control the metabolism of a large array of transcripts. Perturbations in RBP-RNA networks activity have been causally associated with cancer development, but the rational framework describing these contributions remains fragmented. We review here the evidence that RBPs modulate multiple cancer traits, emphasize their functional diversity, and assess future trends in the study of RBPs in cancer...
July 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28715673/activity-level-dna-evidence-evaluation-on-propositions-addressing-the-actor-or-the-activity
#3
Bas Kokshoorn, Bart J Blankers, Jacob de Zoete, Charles E H Berger
More often than not, the source of DNA traces found at a crime scene is not disputed, but the activity or timing of events that resulted in their transfer is. As a consequence, practitioners are increasingly asked to assign a value to DNA evidence given propositions about activities provided by prosecution and defense counsel. Given that the dispute concerns the nature of the activity that took place or the identity of the actor that carried out the activity, several factors will determine how to formulate the propositions...
July 3, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28714325/actor-network-theory-and-micro-learning-networks
#4
Alex Harding
No abstract text is available yet for this article.
July 16, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28687532/studying-scale-up-and-spread-as-social-practice-theoretical-introduction-and-empirical-case-study
#5
James Shaw, Sara Shaw, Joseph Wherton, Gemma Hughes, Trisha Greenhalgh
BACKGROUND: Health and care technologies often succeed on a small scale but fail to achieve widespread use (scale-up) or become routine practice in other settings (spread). One reason for this is under-theorization of the process of scale-up and spread, for which a potentially fruitful theoretical approach is to consider the adoption and use of technologies as social practices. OBJECTIVE: This study aimed to use an in-depth case study of assisted living to explore the feasibility and usefulness of a social practice approach to explaining the scale-up of an assisted-living technology across a local system of health and social care...
July 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28685669/understanding-how-domestic-health-policy-is-integrated-into-foreign-policy-in-south-africa-a-case-for-accelerating-access-to-antiretroviral-medicines
#6
Simon Moeketsi Modisenyane, Stephen James Heinrich Hendricks, Harvey Fineberg
BACKGROUND: South Africa, as an emerging middle-income country, is becoming increasingly influential in global health diplomacy (GHD). However, little empirical research has been conducted to inform arguments for the integration of domestic health into foreign policy by state and non-state actors. This study seeks to address this knowledge gap. It takes the form of an empirical case study which analyses how South Africa integrates domestic health into its foreign policy, using the lens of access to antiretroviral (ARV) medicines...
2017: Global Health Action
https://www.readbyqxmd.com/read/28675136/policy-content-and-stakeholder-network-analysis-for-infant-and-young-child-feeding-in-india
#7
Seema Puri, Sylvia Fernandez, Amrita Puranik, Deepika Anand, Abhay Gaidhane, Zahiruddin Quazi Syed, Archana Patel, Shahadat Uddin, Anne Marie Thow
BACKGROUND: Over the last decade, infant and young child feeding (IYCF) indicators in India have improved. However, poor IYCF practices are still apparent, associated with pervasive high rates of child under-nutrition. Interventions to improve IYCF need augmentation by appropriate policy support to consolidate gains. The aim of this study was to identify opportunities to strengthen and support IYCF policies through a policy content and stakeholder network analysis. METHODS: IYCF policies and guidelines were systematically mapped and coded using predetermined themes...
June 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28675134/overview-of-the-infant-and-young-child-feeding-policy-environment-in-pakistan-federal-sindh-and-punjab-context
#8
Hana Mahmood, Yasmeen Suleman, Tabish Hazir, Durre Samin Akram, Shahadat Uddin, Michael J Dibley, Saleem Abassi, Amara Shakeel, Narjis Kazmi, Anne Marie Thow
BACKGROUND: Appropriate infant and young child feeding (IYCF) practices have been identified as important for appropriate child growth and development. (Ministry of Planning and Development, Ministry of National Health Services, Regulations and Coordination (2012)) Children in Pakistan still experience high rates of malnutrition, indicating a likely need for stronger IYCF policy. The purpose of this study was to identify major stakeholders who shape the IYCF policy environment and analyze which policies protect, promote and support IYCF practices, either directly or indirectly...
June 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28675133/policy-content-and-stakeholder-network-analysis-for-infant-and-young-child-feeding-in-nepal
#9
Sumit Karn, Madhu Dixit Devkota, Shahadat Uddin, Anne Marie Thow
BACKGROUND: Despite concerted effort from government and partners, Nepal continues to have a high burden of under nutrition among children. Identifying opportunities to strengthen policy support for infant and young child feeding (IYCF) is a key component to improve child survival, growth and development. This study aims to explore policy support for IYCF and to identify the influential stakeholders for IYCF for effective future policy development and programmatic action. METHODS: Policies relevant to IYCF were identified through web searches and direct approaches to relevant government ministries...
June 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28675132/policy-and-stakeholder-analysis-of-infant-and-young-child-feeding-programmes-in-sri-lanka
#10
Sanjeeva S P Godakandage, Upul Senarath, Hiranya S Jayawickrama, Indika Siriwardena, S W A D A Wickramasinghe, Prasantha Arumapperuma, Sathyajith Ihalagama, Srisothinathan Nimalan, Ramanathan Archchuna, Claudio Umesh, Shahadat Uddin, Anne Marie Thow
BACKGROUND: Infant and young child feeding practices (IYCF) play a critical role in growth and development of children. A favourable environment supported by appropriate policies and positive contributions from all stakeholders are prerequisites for achieving optimal IYCF practices. This study aimed to assess the IYCF-related policy environment and role of stakeholders in policy making in Sri Lanka, in order to identify opportunities to strengthen the policy environment to better support appropriate IYCF and reduce childhood malnutrition...
June 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28675131/changes-in-the-policy-environment-for-infant-and-young-child-feeding-in-vietnam-bangladesh-and-ethiopia-and-the-role-of-targeted-advocacy
#11
Jody Harris, Edward A Frongillo, Phuong H Nguyen, Sunny S Kim, Purnima Menon
BACKGROUND: There is limited literature examining shifts in policy environments for nutrition and infant and young child feeding (IYCF) over time, and on the potential contribution of targeted advocacy to improved policy environments in low- and middle-income countries. This study tracked changes in the policy environment over a four-year period in three countries, and examined the role of targeted nutrition and IYCF advocacy strategies by a global initiative. METHODS: Qualitative methods, including key informant interviews, social network mapping, document and literature review, and event tracking, were used to gather data on nutrition and IYCF policies and programs, actor networks, and perceptions and salience of nutrition as an issue in 2010 and 2014 in Bangladesh, Ethiopia, and Vietnam...
June 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28675130/analysis-of-stakeholders-networks-of-infant-and-young-child-nutrition-programmes-in-sri-lanka-india-nepal-bangladesh-and-pakistan
#12
Shahadat Uddin, Hana Mahmood, Upul Senarath, Quazi Zahiruddin, Sumit Karn, Sabrina Rasheed, Michael Dibley
BACKGROUND: Effective public policies are needed to support appropriate infant and young child feeding (IYCF) to ensure adequate child growth and development, especially in low and middle income countries. The aim of this study was to: (i) capture stakeholder networks in relation to funding and technical support for IYCF policy across five countries in South Asia (i.e. Sri Lanka, India, Nepal, Bangladesh and Pakistan); and (ii) understand how stakeholder networks differed between countries, and identify common actors and their patterns in network engagement across the region...
June 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28674005/spontaneous-fine-tuning-to-environment-in-many-species-chemical-reaction-networks
#13
Jordan M Horowitz, Jeremy L England
A chemical mixture that continually absorbs work from its environment may exhibit steady-state chemical concentrations that deviate from their equilibrium values. Such behavior is particularly interesting in a scenario where the environmental work sources are relatively difficult to access, so that only the proper orchestration of many distinct catalytic actors can power the dissipative flux required to maintain a stable, far-from-equilibrium steady state. In this article, we study the dynamics of an in silico chemical network with random connectivity in an environment that makes strong thermodynamic forcing available only to rare combinations of chemical concentrations...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28666809/bio-based-industries-joint-undertaking-the-catalyst-for-sustainable-bio-based-economic-growth-in-europe
#14
REVIEW
Philippe Mengal, Marcel Wubbolts, Eleni Zika, Ana Ruiz, Dieter Brigitta, Agata Pieniadz, Sarah Black
This article discusses the preparation, structure and objectives of the Bio-based Industries Joint Undertaking (BBI JU). BBI JU is a public-private partnership (PPP) between the European Commission (EC) and the Bio-based Industries Consortium (BIC), the industry-led private not-for-profit organisation representing the private sectors across the bio-based industries. The model of the public-private partnership has been successful as a new approach to supporting research and innovation and de-risking investment in Europe...
June 27, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28662685/policy-entrepreneurship-and-policy-networks-in-healthcare-systems-the-case-of-israel-s-pediatric-dentistry-reform
#15
Nissim Cohen, Tuvia Horev
BACKGROUND: Can the entry of a policy entrepreneur challenge the equilibrium of a policy network and promote changes that might clash with the goals of powerful civil-servants and/or interest groups and, if so, why and how? Our goal is to examine two sides of the same coin: how does an in-depth analysis of Israel's dental care reform enrich our understanding of policy networks and policy entrepreneurship? Second, how does the literature on policy networks and policy entrepreneurship help us understand this reform? Based on a theoretical framework that appears in the literature of policy entrepreneurship and policy networks, we analyze the motivations, goals and strategies of the main actors involved in the process of reforming pediatric dental care in Israel...
April 21, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28662121/cascades-of-emotional-support-in-friendship-networks-and-adolescent-smoking
#16
Cynthia M Lakon, Cheng Wang, Carter T Butts, Rupa Jose, John R Hipp
Social support from peers and parents provides a key socialization function during adolescence. We examine adolescent friendship networks using a Stochastic Actor-Based modeling approach to observe the flow of emotional support provision to peers and the effect of support from parents, while simultaneously modeling smoking behavior. We utilized one school (n = 976) from The National Longitudinal Study of Adolescent to Adult Health (AddHealth) Study. Our findings suggest that emotional support is transacted through an interdependent contextual system, comprised of both peer and parental effects, with the latter also having distal indirect effects from youths' friends' parents...
2017: PloS One
https://www.readbyqxmd.com/read/28655403/yuan-longping-hybrid-rice-and-the-meaning-of-science-in-the-cultural-revolution-and-beyond
#17
Sigrid Schmalzer
This paper uses the case of hybrid rice to chart changes in the meanings science has carried in China from the Mao era to today. It begins by using Chinese journal articles to reconstruct the 1970s development of hybrid rice technology by a network of diverse historical actors. It then documents the emergence during the Hua Guofeng era (1976-1978) of a historical narrative of hybrid rice centered on the figures of Yuan Longping and Hua Guofeng. Finally, it surveys post-1978 biographies of Yuan Longping to identify changes and continuities in scientific values...
June 24, 2017: Endeavour
https://www.readbyqxmd.com/read/28649120/must-we-embody-context
#18
Barbara Hahn
The essays in this forum brace this meditation on the historiography of technology. Understanding devices incorporates the context of any particular hardware, as John Staudenmaier showed by quantifying the contents of the first decades of Technology and Culture. As contextualist approaches have widened from systems theory through social construction and into the assemblages of actor-network theory, the discipline has kept artifacts at the analytical center: it is the history of technology that scholars seek to understand...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28647433/targeted-release-of-transcription-factors-for-human-cell-reprogramming-by-zebra-cell-penetrating-peptide
#19
Benjamin Caulier, Lionel Berthoin, Helène Coradin, Frédéric Garban, Marie Claire Dagher, Benoît Polack, Bertrand Toussaint, Jean Luc Lenormand, David Laurin
Transcription factors (TFs) are key actors of the control of gene expression and consequently of every major process within cells, ranging from cell fate determination, cell cycle control and response to environment. Their ectopic expression has proven high potential in reprogramming cells for regenerative medicine; ontogenesis studies and cell based modelling. Direct delivery of proteins could represent an alternative to current reprogramming methods using gene transfer but still needs technological improvements...
June 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28642272/networks-underpinning-symbiosis-revealed-through-cross-species-eqtl-mapping
#20
Yuelong Guo, Sylwia Fudali, Jacinta Gimeno, Peter DiGennaro, Stella Chang, Valerie M Williamson, David McK Bird, Dahlia M Nielsen
Organisms engage in extensive cross-species molecular dialogue, yet the underlying molecular actors are known for only a few interactions. Many techniques have been designed to uncover genes involved in signaling between organisms. Typically, these focus on only one of the partners. We developed an expression quantitative trait locus (eQTL) mapping-based approach to identify cause-and-effect relationships between genes from two partners engaged in an interspecific interaction. We demonstrated the approach by assaying expression of ninety-eight isogenic plants (Medicago truncatula), each inoculated with a genetically distinct line of the diploid parasitic nematode Meloidogyne hapla With this design, systematic differences in gene expression across host plants could be mapped to genetic polymorphisms of their infecting parasites...
June 22, 2017: Genetics
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