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https://www.readbyqxmd.com/read/27903985/the-tissue-inhibitor-of-metalloproteinases-1-timp-1-promotes-survival-and-migration-of-acute-myeloid-leukemia-cells-through-cd63-pi3k-akt-p21-signaling
#1
Dorian Forte, Valentina Salvestrini, Giulia Corradi, Lara Rossi, Lucia Catani, Roberto M Lemoli, Michele Cavo, Antonio Curti
We and others have shown that the Tissue Inhibitor of Metalloproteinases-1 (TIMP-1), a member of the inflammatory network exerting pleiotropic effects in the bone marrow (BM) microenvironment, regulates the survival and proliferation of different cell types, including normal hematopoietic progenitor cells. Moreover, TIMP-1 has been shown to be involved in cancer progression. However, its role in leukemic microenvironment has not been addressed. Here, we investigated the activity of TIMP-1 on Acute Myelogenous Leukemia (AML) cell functions...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898689/the-spatial-properties-of-radical-environmental-organizations-in-the-uk-do-or-die
#2
Zack W Almquist, Benjamin E Bagozzi
Radical environmental groups and their members have a wide and varied agenda which often encompasses both local and global issues. In their efforts to call attention to environmental problems, communicate with like-minded groups, and mobilize support for their activities, radical environmental organizations also produce an enormous amount of text, which can be used to estimate the complex communications and task-based networks that underlie these organizations. Moreover, the tactics employed to garnish attention for these groups' agenda can range from peaceful activities such as information dissemination to violent activities such as fire-bombing buildings...
2016: PloS One
https://www.readbyqxmd.com/read/27893217/multi-relational-measurement-for-latent-construct-networks
#3
Laura M Koehly, Christopher Steven Marcum
Multiple item scales have long been used to measure latent constructs on individual-level data. This is appropriate when an otherwise unobserved construct is indirectly measured by combining observable correlated characteristics that are thought to measure slightly different dimensions of that construct. Network data, which consist of observations on the relationships between a set of actors, however, are typically drawn from single-relation measurements. While this approach is sufficient for learning about discrete relations (communication, coauthorship, etc...
November 28, 2016: Psychological Methods
https://www.readbyqxmd.com/read/27873413/six-degrees-of-separation-the-small-world-of-medical-education
#4
Wolf E Hautz, Gert Krummrey, Aristomenis Exadaktylos, Stefanie C Hautz
CONTEXT: Conventional wisdom has it that everyone on earth is on average only six steps away from knowing any other person through 'a friend of a friend'. On a local level, however, many people experience that most of their acquaintances know each other. It is thus hard to imagine how such a highly clustered group could be so well connected to the rest of the world. In this paper, we investigate how co-authorship connects scholars in medical education and whether the six degrees of separation hypothesis also applies to the network of authors in the field...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27865132/a-network-approach-to-policy-framing-a-case-study-of-the-national-aboriginal-and-torres-strait-islander-health-plan
#5
Jennifer Browne, Evelyne de Leeuw, Deborah Gleeson, Karen Adams, Petah Atkinson, Rick Hayes
Aboriginal health policy in Australia represents a unique policy subsystem comprising a diverse network of Aboriginal-specific and "mainstream" organisations, often with competing interests. This paper describes the network structure of organisations attempting to influence national Aboriginal health policy and examines how the different subgroups within the network approached the policy discourse. Public submissions made as part of a policy development process for the National Aboriginal and Torres Strait Islander Health Plan were analysed using a novel combination of network analysis and qualitative framing analysis...
November 9, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27859864/l-dopa-induced-dyskinesia-and-neuroinflammation-do-microglia-and-astrocytes-play-a-role
#6
Anna R Carta, Giovanna Mulas, Mariza Bortolanza, Terence Duarte, Elisabetta Pillai, Gilberto Fisone, Rita Vozari Raisman, Elaine Del Bel
In Parkinson's disease (PD), L-DOPA therapy leads to the emergence of motor complications including L-DOPA-induced dyskinesia (LID). LID relies on a sequence of pre- and postsynaptic neuronal events, leading to abnormal corticostriatal neurotransmission and maladaptive changes in striatal projection neurons. In recent years, additional non-neuronal mechanisms have been proposed to contribute to LID. Among these mechanisms considerable attention has been focused on L-DOPA-induced inflammatory responses. Microglia and astrocytes are the main actors in neuroinflammatory responses, and their double role at the interface between immune and neurophysiological responses is starting to be elucidated...
November 17, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27854462/friend-influence-on-early-adolescent-disruptive-behavior-in-the-classroom-teacher-emotional-support-matters
#7
Huiyoung Shin, Allison M Ryan
This research investigated how the level of disruptive behavior and friend influence on disruptive behavior varies across classrooms in relation to teacher emotional support. Data were collected from 48 fifth- and sixth-grade classrooms (N = 879 students) and included classroom observations at Wave 1 and student reports of their disruptive behavior and peer nominations of their friends at Waves 1 and 2 (fall and spring of the school year, about 6 months apart). In the fall, there were no differences in the level of disruptive behavior between classes that were low versus high in teacher emotional support...
November 17, 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27836258/adaptive-nearly-optimal-control-for-a-class-of-continuous-time-nonaffine-nonlinear-systems-with-inequality-constraints
#8
Quan-Yong Fan, Guang-Hong Yang
The state inequality constraints have been hardly considered in the literature on solving the nonlinear optimal control problem based the adaptive dynamic programming (ADP) method. In this paper, an actor-critic (AC) algorithm is developed to solve the optimal control problem with a discounted cost function for a class of state-constrained nonaffine nonlinear systems. To overcome the difficulties resulting from the inequality constraints and the nonaffine nonlinearities of the controlled systems, a novel transformation technique with redesigned slack functions and a pre-compensator method are introduced to convert the constrained optimal control problem into an unconstrained one for affine nonlinear systems...
November 8, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27833252/the-double-standard-at-sexual-debut-gender-sexual-behavior-and-adolescent-peer-acceptance
#9
Derek A Kreager, Jeremy Staff, Robin Gauthier, Eva S Lefkowitz, Mark E Feinberg
A sexual double standard in adolescence has important implications for sexual development and gender inequality. The present study uses longitudinal social network data (N = 914; 11-16 years of age) to test if gender moderates associations between adolescents' sexual behaviors and peer acceptance. Consistent with a traditional sexual double standard, female adolescents who reported having sex had significant decreases in peer acceptance over time, whereas male adolescents reporting the same behavior had significant increases in peer acceptance...
October 2016: Sex Roles
https://www.readbyqxmd.com/read/27832929/who-collaborates-and-why-assessment-and-diagnostic-of-governance-network-integration-for-salmon-restoration-in-puget-sound-usa
#10
Jesse S Sayles, Jacopo A Baggio
Governance silos are settings in which different organizations work in isolation and avoid sharing information and strategies. Siloes are a fundamental challenge for environmental planning and problem solving, which generally requires collaboration. Siloes can be overcome by creating governance networks. Studying the structure and function of these networks is important for understanding how to create institutional arrangements that can respond to the biophysical dynamics of a specific natural resource system (i...
November 7, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27831897/actor-critic-off-policy-learning-for-optimal-control-of-multiple-model-discrete-time-systems
#11
Jan Skach, Bahare Kiumarsi, Frank L Lewis, Ondrej Straka
In this paper, motivated by human neurocognitive experiments, a model-free off-policy reinforcement learning algorithm is developed to solve the optimal tracking control of multiple-model linear discrete-time systems. First, an adaptive self-organizing map neural network is used to determine the system behavior from measured data and to assign a responsibility signal to each of system possible behaviors. A new model is added if a sudden change of system behavior is detected from the measured data and the behavior has not been previously detected...
November 2, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27828594/-rural-endemic-diseases-health-and-development-emmanuel-dias-and-the-construction-of-a-network-of-allies-against-chagas-disease
#12
Simone Petraglia Kropf
The scope of this article is to analyze the trajectory of Emmanuel Dias (1908-1962), a researcher at the Oswaldo Cruz Institute (OCI) and director of the Center for Studies and Prophylaxis of Chagas Disease (OCI outpost established in 1943 in the city of Bambuí, Minas Gerais), as a key actor in the acknowledgement of Chagas disease as a public health problem in Brazil and the Americas. It seeks to show that the conquest of this acknowledgement, the cornerstone of which was the staging of the first campaign to combat the disease in Brazil in 1950, was made possible by the intense political mobilization of Dias together with the various social groups, such as physicians, politicians and residents of rural areas, public health officials, governments and international organizations...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27810766/contextual-and-interdependent-causes-of-climate-change-adaptation-barriers-insights-from-water-management-institutions-in-himachal-pradesh-india
#13
Adani Azhoni, Ian Holman, Simon Jude
Research on adaptation barriers is increasing as the need for climate change adaptation becomes evident. However, empirical studies regarding the emergence, causes and sustenance of adaptation barriers remain limited. This research identifies key contextual causes of adaptation barriers in water institutions in the mountainous Himalayan state of Himachal Pradesh in northern India. Semi-structured interviews were carried out with representatives from twenty-six key governmental, non-governmental, academic and research institutions in the State with responsibilities spanning domestic water supply, irrigation and hydropower generation, environmental monitoring and research...
October 31, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27790382/resilience-and-disaster-trends-in-the-philippines-opportunities-for-national-and-local-capacity-building
#14
Tilly Alcayna, Vincenzo Bollettino, Philip Dy, Patrick Vinck
INTRODUCTION:  The Philippines is one of the top countries in the world at risk of climate-related disasters. For populations subsisting at the poverty line in particular, but also the nation as a whole, daily lives and wellbeing are routinely challenged. The Philippines government takes disaster risk seriously and has devoted significant resources to build disaster capacity and reduce population exposure and vulnerability, nationally and locally. This paper explores the policy and institutional mechanisms for disaster risk reduction management and research which have been conducted in the Philippines related to disaster preparedness, management and resilience...
September 14, 2016: PLoS Currents
https://www.readbyqxmd.com/read/27789102/nps-and-the-methadone-queue-spillages-of-space-and-time
#15
Liviu Alexandrescu
BACKGROUND: Between 2008 and 2013, powder-stimulants sold by 'head shops' as novel psychoactive substances (NPS) or 'legal highs' have displaced heroin among groups of injecting substance users in Bucharest, Romania. Rising HIV-infection rates and other medical or social harms have been reported to follow this trend. METHODS: The study builds on two sets of original (N=30) and existing (N=20) interview data and on observations collected mainly at the site of a methadone substitution treatment facility...
October 24, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27782972/professional-networks-and-the-alignment-of-individual-perceptions-about-medical-innovation
#16
Valentina Iacopino, Daniele Mascia, Americo Cicchetti
BACKGROUND: In recent decades, the role of technology in health care organizations has become increasingly relevant because it enhances health care outcomes and the achievement of clinical goals. Extant research demonstrates that the effectiveness of a medical innovation depends largely on health care professionals' perceptions of its usefulness and impact on their activities and practices. We also know that interaction among social actors contributes to the shaping of their judgments and opinions regarding innovation...
October 25, 2016: Health Care Management Review
https://www.readbyqxmd.com/read/27768995/non-medical-use-of-prescription-drugs-among-illicit-drug-users-a-case-study-on-an-online-drug-forum
#17
Sanna Rönkä, Anu Katainen
BACKGROUND: The non-medical use of prescription drugs is a growing phenomenon associated with increasing health-related harms. However, little is known about the drivers of this process among illicit drug users. Our aim is to show how the qualities of pharmaceutical drugs, pharmaceutical related knowledge, online communities sharing this knowledge and medical professionals mediate and transform the consumption behaviour related to pharmaceutical drugs. METHODS: The data consist of discussion threads from an online drug use forum...
October 18, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27767241/a-roadmap-for-knowledge-exchange-and-mobilization-research-in-conservation-and-natural-resource-management
#18
Vivian M Nguyen, Nathan Young, Steven J Cooke
Scholars across all disciplines have long been interested in how knowledge moves within and beyond their community of peers. In conservation and natural resource management, however, we are lagging behind. Rapid environmental changes and calls for sustainable management practices mean that we urgently need to be using the best knowledge possible in forming decisions, policies, and practices to protect biodiversity and sustainably manage vulnerable natural resources. While the conservation literature on knowledge exchange (KE) and knowledge mobilization (KMb) has grown in recent years, much of it is based on context-specific case studies...
October 21, 2016: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/27766087/co-evolution-of-friendships-and-antipathies-a-longitudinal-study-of-preschool-peer-groups
#19
João R Daniel, António J Santos, Marta Antunes, Marília Fernandes, Brian E Vaughn
We used stochastic actor-based models to test whether the developmental dynamics of friendships and antipathies in preschool peer groups (followed throughout three school years) were co-dependent. We combined choices from three sociometric tasks of 142 children to identify friendship and antipathy ties and used SIENA to model network dynamics. Our results show that different social processes drive the development of friendship and antipathy ties, and that they do not develop in association (i.e., friendship ties are not dependent on existing antipathies, and vice-versa)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27756447/the-reach-and-flow-of-health-information-in-two-aboriginal-communities-a-social-network-analysis
#20
Scott Winch, Nageen Ahmed, Christopher Rissel, Michelle Maxwell, Joanna Coutts, Kerri Lucas
The aim of the present paper was to explore how social networks enable dissemination of health information within two Aboriginal communities in New South Wales. The study design was modelled on a social network analysis socio-centric model. Data collection was conducted primarily by Aboriginal community members who were trained as community researchers. Participants reported on their patterns of interaction and who they provided or received health information from, and awareness of the Aboriginal Enhancement of the Get Healthy Information and Coaching Service...
October 19, 2016: Australian Journal of Primary Health
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