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https://www.readbyqxmd.com/read/28454160/spectral-selectivity-in-optical-fiber-capillary-dye-lasers
#1
Esmaeil Mobini, Behnam Abaie, Mostafa Peysokhan, Arash Mafi
We explore the spectral properties of a capillary dye laser in the highly multimode regime. Our experiments indicate that the spectral behavior of the laser does not conform to a simple Fabry-Perot (FP) analysis; rather, it is strongly dictated by a Vernier resonant mechanism involving multiple modes, which propagate with different group velocities. The laser operates over a very broad spectral range and the Vernier effect gives rise to a free spectral range, which is orders of magnitude larger than that expected from a simple FP mechanism...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28448065/construction-of-a-map-based-reference-genome-sequence-for-barley-hordeum-vulgare-l
#2
Sebastian Beier, Axel Himmelbach, Christian Colmsee, Xiao-Qi Zhang, Roberto A Barrero, Qisen Zhang, Lin Li, Micha Bayer, Daniel Bolser, Stefan Taudien, Marco Groth, Marius Felder, Alex Hastie, Hana Šimková, Helena Staňková, Jan Vrána, Saki Chan, María Muñoz-Amatriaín, Rachid Ounit, Steve Wanamaker, Thomas Schmutzer, Lala Aliyeva-Schnorr, Stefano Grasso, Jaakko Tanskanen, Dharanya Sampath, Darren Heavens, Sujie Cao, Brett Chapman, Fei Dai, Yong Han, Hua Li, Xuan Li, Chongyun Lin, John K McCooke, Cong Tan, Songbo Wang, Shuya Yin, Gaofeng Zhou, Jesse A Poland, Matthew I Bellgard, Andreas Houben, Jaroslav Doležel, Sarah Ayling, Stefano Lonardi, Peter Langridge, Gary J Muehlbauer, Paul Kersey, Matthew D Clark, Mario Caccamo, Alan H Schulman, Matthias Platzer, Timothy J Close, Mats Hansson, Guoping Zhang, Ilka Braumann, Chengdao Li, Robbie Waugh, Uwe Scholz, Nils Stein, Martin Mascher
Barley (Hordeum vulgare L.) is a cereal grass mainly used as animal fodder and raw material for the malting industry. The map-based reference genome sequence of barley cv. 'Morex' was constructed by the International Barley Genome Sequencing Consortium (IBSC) using hierarchical shotgun sequencing. Here, we report the experimental and computational procedures to (i) sequence and assemble more than 80,000 bacterial artificial chromosome (BAC) clones along the minimum tiling path of a genome-wide physical map, (ii) find and validate overlaps between adjacent BACs, (iii) construct 4,265 non-redundant sequence scaffolds representing clusters of overlapping BACs, and (iv) order and orient these BAC clusters along the seven barley chromosomes using positional information provided by dense genetic maps, an optical map and chromosome conformation capture sequencing (Hi-C)...
April 27, 2017: Scientific Data
https://www.readbyqxmd.com/read/28445214/teaching-the-social-determinants-of-health-a-path-to-equity-or-a-road-to-nowhere
#3
Malika Sharma, Andrew D Pinto, Arno K Kumagai
Medical schools are increasingly called to include social responsibility in their mandates. As such, they are focusing their attention on the social determinants of health (SDOH) as key drivers in the health of the patients and communities they serve. However, underlying this emphasis on SDOH is the assumption that teaching medical students about SDOH will lead future physicians to take action to help achieve health equity. There is little evidence to support this belief. In many ways, the current approach to SDOH within medical education positions the SDOH as "facts to be known" rather than as "conditions to be challenged and changed...
April 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441484/fully-quantum-description-of-the-zundel-ion-combining-variational-quantum-monte-carlo-with-path-integral-langevin-dynamics
#4
Félix Mouhat, Sandro Sorella, Rodolphe Vuilleumier, Antonino Marco Saitta, Michele Casula
We introduce a novel approach for a fully quantum description of coupled electron-ion systems from first principles. It combines the variational quantum Monte Carlo solution of the electronic part with the path integral formalism for the quantum nuclear dynamics. On the one hand, the path integral molecular dynamics includes nuclear quantum effects by adding a set of fictitious classical particles (beads) aimed at reproducing nuclear quantum fluctuations via a harmonic kinetic term. On the other hand, variational quantum Monte Carlo can provide Born-Oppenheimer potential energy surfaces with a precision comparable to the most advanced post Hartree-Fock approaches, and with a favorable scaling with the system size...
April 25, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28441425/role-of-route-previewing-strategies-on-climbing-fluency-and-exploratory-movements
#5
Ludovic Seifert, Romain Cordier, Dominic Orth, Yoan Courtine, James L Croft
This study examined the role of route previewing strategies on climbing fluency and on exploratory movements of the limbs, in order to understand whether previewing helps people to perceive and to realize affordances. Eight inexperienced and ten experienced climbers previewed a 10 m high route of 5b difficulty on French scale, then climbed it with a top-rope as fluently as possible. Gaze behavior was collected from an eye tracking system during the preview and allowed us to determine the number of times they scanned the route, and which of four route previewing strategies (fragmentary, ascending, zigzagging, and sequence-of-blocks) they used...
2017: PloS One
https://www.readbyqxmd.com/read/28438183/semaphorin-plexin-signaling-influences-early-ventral-telencephalic-development-and-thalamocortical-axon-guidance
#6
Manuela D Mitsogiannis, Graham E Little, Kevin J Mitchell
BACKGROUND: Sensory processing relies on projections from the thalamus to the neocortex being established during development. Information from different sensory modalities reaching the thalamus is segregated into specialized nuclei, whose neurons then send inputs to cognate cortical areas through topographically defined axonal connections. Developing thalamocortical axons (TCAs) normally approach the cortex by extending through the subpallium; here, axonal navigation is aided by distributed guidance cues and discrete cell populations, such as the corridor neurons and the internal capsule (IC) guidepost cells...
April 24, 2017: Neural Development
https://www.readbyqxmd.com/read/28437935/terahertz-artificial-material-based-on-integrated-metal-rod-array-for-phase-sensitive-fluid-detection
#7
Borwen You, Ching-Yu Chen, Chin-Ping Yu, Tze-An Liu, Toshiaki Hattori, Ja-Yu Lu
A terahertz artificial material composed of metal rod array is experimentally investigated on its transmission spectral property and successfully incorporated into microfluidics as a miniaturized terahertz waveguide with an extended optical-path-length for label-free fluidic sensing. Theoretical and experimental characterizations of terahertz transmission spectra show that the wave guidance along the metal rod array originates from the resonance of transverse-electric-polarized waves within the metal rod slits...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437028/esut-educational-video-on-fluoroscopic-guided-puncture-in-pcnl-all-techniques-step-by-step
#8
Iason Kyriazis, Evangelos Liatsikos, Odysseas Sopilidis, Panagiotis Kallidonis, Andreas Skolarikos
OBJECTIVE: Kidney puncture during percutaneous nephrolithotomy (PCNL) is regarded as one of the most demanding aspects of the procedure and only a minority of urologists perform this step without assistance by a radiologist. Currently a wide variation of fluoroscopic guided techniques is available in clinical practice. In this work we describe the most common fluoroscopic guided access techniques in a step-by-step manner aiming to assist on the standardization of their technique and terminology...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28436162/the-path-forward-2015-international-children-s-tumor-foundation-conference-on-neurofibromatosis-type-1-type-2-and-schwannomatosis
#9
Jaishri O Blakeley, Annette Bakker, Anne Barker, Wade Clapp, Rosalie Ferner, Michael J Fisher, Marco Giovannini, David H Gutmann, Matthias A Karajannis, Joseph L Kissil, Eric Legius, Alison C Lloyd, Roger J Packer, Vijaya Ramesh, Vincent M Riccardi, David A Stevenson, Nicole J Ullrich, Meena Upadhyaya, Anat Stemmer-Rachamimov
The Annual Children's Tumor Foundation International Neurofibromatosis Meeting is the premier venue for connecting discovery, translational and clinical scientists who are focused on neurofibromatosis types 1 and 2 (NF1 and NF2) and schwannomatosis (SWN). The meeting also features rare tumors such as glioma, meningioma, sarcoma, and neuroblastoma that occur both within these syndromes and spontaneously; associated with somatic mutations in NF1, NF2, and SWN. The meeting addresses both state of the field for current clinical care as well as emerging preclinical models fueling discovery of new therapeutic targets and discovery science initiatives investigating mechanisms of tumorigenesis...
April 24, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28435773/giant-faraday-rotation-through-ultrasmall-fe-0-n-clusters-in-superparamagnetic-feo-sio2-vitreous-films
#10
Yuko Nakatsuka, Kilian Pollok, Torsten Wieduwilt, Falko Langenhorst, Markus A Schmidt, Koji Fujita, Shunsuke Murai, Katsuhisa Tanaka, Lothar Wondraczek
Magnetooptical (MO) glasses and, in particular, Faraday rotators are becoming key components in lasers and optical information processing, light switching, coding, filtering, and sensing. The common design of such Faraday rotator materials follows a simple path: high Faraday rotation is achieved by maximizing the concentration of paramagnetic ion species in a given matrix material. However, this approach has reached its limits in terms of MO performance; hence, glass-based materials can presently not be used efficiently in thin film MO applications...
April 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28435754/establishing-successful-patient-centered-medical-homes-in-rural-hawai-i-three-strategies-to-consider
#11
Melissa Nelson Scribner, Kasey Kehoe
The challenges to healthcare delivery posed by Hawai'i's unique geography, physician shortages, and dispersed population are of particular importance in light of implementing the Affordable Care Act (ACA). This study draws on central goals laid out in the ACA - to decrease costs, increase access, and improve patient outcomes. The use of the Patient-Centered Medical Homes (PCMHs) is a care model that has the potential to meet all three goals. How to identify the most effective way to develop PCMHs in the specific context of Hawai'i is the focus of this study...
March 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28434935/solid-nanofoams-based-on-cellulose-nanofibers-and-indomethacin-the-effect-of-processing-parameters-and-drug-content-on-material-structure
#12
J Bannow, J-W Benjamins, J Wohlert, K Löbmann, A J Svagan
The unique colloidal properties of cellulose nanofibers (CNF), makes it a very interesting new excipient in pharmaceutical formulations, as CNF in combination with some poorly-soluble drug can create nanofoams with closed cells. Previous nanofoams, created with the model drug indomethacin, demonstrated a prolonged release compared to films, owing to the tortuous diffusion path that the drug needs to take around the intact air-bubbles. However, the nanofoam was only obtained at a relatively low drug content of 21wt% using fixed processing parameters...
April 20, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28433018/atomistic-insight-into-the-non-classical-nucleation-mechanism-during-solidification-in-ni
#13
Grisell Díaz Leines, Ralf Drautz, Jutta Rogal
Nucleation is a key step during crystallization, but a complete understanding of the fundamental atomistic processes remains elusive. We investigate the mechanism of nucleation during solidification in nickel for various undercoolings using transition path sampling simulations. The temperature dependence of the free energy barriers and rate constants that we obtain is consistent with the predictions of classical nucleation theory and experiments. However, our analysis of the transition path ensemble reveals a mechanism that deviates from the classical picture of nucleation: the growing solid clusters have predominantly non-spherical shapes and consist of face-centered-cubic and random hexagonal-close-packed coordinated atoms surrounded by a cloud of prestructured liquid...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28426080/c-reactive-protein-and-interleukin-6-microfluidic-immunoassays-with-on-chip-pre-stored-reagents-and-centrifugo-pneumatic-liquid-control
#14
Y Zhao, G Czilwik, V Klein, K Mitsakakis, R Zengerle, N Paust
We present a fully automated centrifugal microfluidic method for particle based protein immunoassays. Stick-pack technology is employed for pre-storage and release of liquid reagents. Quantitative layout of centrifugo-pneumatic particle handling, including timed valving, switching and pumping is assisted by network simulations. The automation is exclusively controlled by the spinning frequency and does not require any additional means. New centrifugal microfluidic process chains are developed in order to sequentially supply wash buffer based on frequency dependent stick-pack opening and pneumatic pumping to perform two washing steps from one stored wash buffer; pre-store and re-suspend functionalized microparticles on a disk; and switch between the path of the waste fluid and the path of the substrate reaction product with 100% efficiency...
April 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28425680/adaptation-to-health-states-sick-yet-better-off
#15
Patricia Cubí-Mollá, Mireia Jofre-Bonet, Victoria Serra-Sastre
Healthcare funding decisions in the UK rely on health state valuations of the general public. However, it has been shown that there is disparity between the valuation of the impact of hypothetical conditions on health and the reported health by those experiencing them. Patients' adaptation to health states is among the most common explanations for this discrepancy. Being diagnosed with a disease appears to affect individual perception of health over time so that better subjective health may be reported over a disease trajectory...
April 20, 2017: Health Economics
https://www.readbyqxmd.com/read/28424653/disentangling-stigma-from-functional-neurological-disorders-conference-report-and-roadmap-for-the-future
#16
Karen S Rommelfanger, Stewart A Factor, Suzette LaRoche, Phyllis Rosen, Raymond Young, Mark H Rapaport
A multidisciplinary expert review of key issues and future directions from the conference "Controversial labels and clinical uncertainties: psychogenic disorders, conversion disorder, and functional symptoms." On October 9 and 10, 2015, a conference entitled "Controversial labels and clinical uncertainties: psychogenic disorders, conversion disorder, and functional symptoms" was held at the Center for Ethics, Emory University, Atlanta, GA, USA. This conference brought together a select group of 30 distinguished thought leaders and practitioners, including ethicists, researchers, clinicians, humanities scholars, and advocates to discuss the unique challenges and controversies related to the diagnosis, treatment, and stigma for patients with what is currently recognized as functional ("psychogenic") neurological disorders...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28424634/when-the-second-language-takes-the-lead-neurocognitive-processing-changes-in-the-first-language-of-adult-attriters
#17
Kristina Kasparian, Karsten Steinhauer
Although research on multilingualism has revealed continued neuroplasticity for language-learning beyond what was previously expected, it remains controversial whether and to what extent a second language (L2) acquired in adulthood may induce changes in the neurocognitive processing of a first language (L1). First language (L1) attrition in adulthood offers new insight on neuroplasticity and the factors that modulate neurocognitive responses to language. To date, investigations of the neurocognitive correlates of L1 attrition and of factors influencing these mechanisms are still scarce...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28424626/a-rat-immobilization-model-based-on-cage-volume-reduction-a-physiological-model-for-bed-rest
#18
Enrica Marmonti, Sílvia Busquets, Míriam Toledo, Marina Ricci, Marc Beltrà, Victòria Gudiño, Francesc Oliva, José M López-Pedrosa, Manuel Manzano, Ricardo Rueda, Francisco J López-Soriano, Josep M Argilés
Bed rest has been an established treatment in the past prescribed for critically illness or convalescing patients, in order to preserve their body metabolic resource, to prevent serious complications and to support their rapid path to recovery. However, it has been reported that prolonged bed rest can have detrimental consequences that may delay or prevent the recovery from clinical illness. In order to study disuse-induced changes in muscle and bone, as observed during prolonged bed rest in humans, an innovative new model of muscle disuse for rodents is presented...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28422426/dinosaurs-chameleons-humans-and-evo-devo-path-linking-%C3%A3-tienne-geoffroy-s-teratology-waddington-s-homeorhesis-alberch-s-logic-of-monsters-and-goldschmidt-hopeful-monsters
#19
REVIEW
Rui Diogo, Geoffrey Guinard, Raul E Diaz
Since the rise of evo-devo (evolutionary developmental biology) in the 1980s, few authors have attempted to combine the increasing knowledge obtained from the study of model organisms and human medicine with data from comparative anatomy and evolutionary biology in order to investigate the links between development, pathology, and macroevolution. Fortunately, this situation is slowly changing, with a renewed interest in evolutionary developmental pathology (evo-devo-path) in the past decades, as evidenced by the idea to publish this special, and very timely, issue on "Developmental Evolution in Biomedical Research...
May 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28421474/social-safeness-and-disordered-eating-exploring-underlying-mechanisms-of-body-appreciation-and-inflexible-eating
#20
Catarina Pinto, Cláudia Ferreira, Ana Laura Mendes, Inês A Trindade
Feelings of social safeness and connectedness have been associated with adaptive emotion regulation processes and well-being indicators. Further, literature has demonstrated that interpersonal experiences play an important role in the etiology and maintenance of body and eating psychopathology. However, the study of the role of social variables and emotion regulation processes in the engagement in inflexible eating rules and eating psychopathology is still in its early stages. The current study aims to fill some gaps within the literature and explore the mediator role of body appreciation and inflexible eating rules in the link between social safeness and disordered eating...
April 18, 2017: Eating and Weight Disorders: EWD
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