Grace Hahm, Frenio A Redeker, Kaveh Jorabchi
Prevalence of F, Cl, S, P, Br, and I in pharmaceuticals and environmental contaminants has promoted standard-free quantitation using analyte-independent heteroatom responses in inductively coupled plasma (ICP)-MS. However, in-plasma ionization challenges and element-dependent isobaric interference removal methods have hampered the multielement nonmetal detection in ICP-MS. Here, we examine an alternative approach to enhance multielement detection capabilities. Analytes are introduced into an ICP leading to post-plasma formation of HF, HCl, H3 PO3 , H2 SO4 , HBr, and HI, which are then chemically ionized to BaF+ , BaCl+ , BaH2 PO3 + , BaHSO4 + , BaBr+ , and BaI+ via reactions with barium-containing ions supplied by a nanospray...
April 22, 2024: Journal of the American Society for Mass Spectrometry