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https://www.readbyqxmd.com/read/29782820/onchocerciasis-prevalence-human-migration-and-risks-for-onchocerciasis-elimination-in-the-upper-mouhoun-nakamb%C3%A3-and-nazinon-river-basins-in-burkina-faso
#1
Achille S Nikièma, Lassane Koala, Rory J Post, Alain B Paré, Claude Montant Kafando, François Drabo, Adrien M G Belem, Roch K Dabiré, Soungalo Traoré
Historically, the whole of Burkina Faso was considered to be endemic for onchocerciasis (except a small area in the far north of the country) with prevalence rates 60-80%, but all endemic areas were included in the World Health Organisation Onchocerciasis Control Programme, which operated a system of vector control by larviciding beginning in 1974. In Burkina Faso larviciding had been phased out by 1989 when it was considered that onchocerciasis had been reduced to levels below the transmission breakpoint (and any residual infections would disappear without further intervention)...
May 18, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29781934/absolute-reliability-and-concurrent-validity-of-the-stryd-system-for-the-assessment-of-running-stride-kinematics-at-different-velocities
#2
Felipe García-Pinillos, Luis E Roche-Seruendo, Noel Marcén-Cinca, Luis A Marco-Contreras, Pedro A Latorre-Román
García-Pinillos, F, Roche-Seruendo, LE, Marcen-Cinca, N, Marco-Contreras, LA, and Latorre-Román, PA. Absolute reliability and concurrent validity of the Stryd system for the assessment of running stride kinematics at different velocities. J Strength Cond Res XX(X): 000-000, 2018-This study aimed to determine the absolute reliability and to evaluate the concurrent validity of the Stryd system for measuring spatiotemporal variables during running at different velocities (8-20 km·h) by comparing data with another widely used device (the OptoGait system)...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29780871/computer-based-evaluation-of-alzheimer-s-disease-and-mild-cognitive-impairment-patients-during-a-picture-description-task
#3
Laura Hernández-Domínguez, Sylvie Ratté, Gerardo Sierra-Martínez, Andrés Roche-Bergua
Introduction: We present a methodology to automatically evaluate the performance of patients during picture description tasks. Methods: Transcriptions and audio recordings of the Cookie Theft picture description task were used. With 25 healthy elderly control (HC) samples and an information coverage measure, we automatically generated a population-specific referent. We then assessed 517 transcriptions (257 Alzheimer's disease [AD], 217 HC, and 43 mild cognitively impaired samples) according to their informativeness and pertinence against this referent...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780527/experimental-and-theoretical-evidence-of-a-supercritical-like-transition-in-an-organic-semiconductor-presenting-colossal-uniaxial-negative-thermal-expansion
#4
Arie van der Lee, Gilles H Roche, Guillaume Wantz, Joël J E Moreau, Olivier J Dautel, Jean-Sébastien Filhol
Thermal expansion coefficients of most materials are usually small, typically up to 50 parts per million per kelvin, and positive, i.e. materials expand when heated. Some materials show an atypical shrinking behavior in one or more crystallographic directions when heated. Here we show that a high mobility thiophene-based organic semiconductor, BHH-BTBT , has an exceptionally large negative expansion between 95 and 295 K (-216 < α 2 = α b < -333 MK-1 ), being compensated by an even larger positive expansion in the perpendicular direction (287 < α 1 < 634 MK-1 )...
April 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29777770/construction-and-feasibility-study-of-the-sofmer-activity-score-sas-a-new-assessment-of-physical-and-cognitive-activity
#5
M D Morard, S Gonzalez-Monge, P Rippert, S Roche, J C Bernard, D Lagauche, C Delvert, J Luauté, S Jacquin Courtois, F Caillet, J Di Marco, F Ghelfi, S Otmani, P Calmels, M Royet, P A Joseph, R Ecochard, G Rode, C Vuillerot
OBJECTIVES: For hospitalizations in rehabilitation centers (RCs) in France, the quantification of healthcare givers' activity is based on the dependency of the patients, defined as a total or partial inability to perform activities required for daily living without help. The tools currently used to quantify dependency are not sufficiently precise. Here we describe the construction of a new tool, the SOFMER Activity Score (SAS scoring), which allows for a good description of the level of activity of patients hospitalized in RCs, and a feasibility study of the tool...
May 16, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29774561/the-relationship-between-differential-stimulus-relatedness-and-implicit-measure-effect-sizes
#6
Jamie Cummins, Bryan Roche, Ian Tyndall, Aoife Cartwright
Implicit measures have been hypothesized to allow researchers to ascertain the existence and strength of relations between stimuli, often in the context of research on attitudes. However, little controlled behavioral research has focused on whether stimulus relations, and the degree of relatedness within such relations, are indexed by implicit measures. The current study eamined this issue using a behavior-analytic implicit-style stimulus relation indexing procedure known as the Function Acquisition Speed Test (FAST)...
May 17, 2018: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/29774230/early-vocal-development-in-autism-spectrum-disorder-rett-syndrome-and-fragile-x-syndrome-insights-from-studies-using-retrospective-video-analysis
#7
Laura Roche, Dajie Zhang, Katrin D Bartl-Pokorny, Florian B Pokorny, Björn W Schuller, Gianluca Esposito, Sven Bölte, Herbert Roeyers, Luise Poustka, Markus Gugatschka, Hannah Waddington, Ralf Vollmann, Christa Einspieler, Peter B Marschik
This article provides an overview of studies assessing the early vocalisations of children with autism spectrum disorder (ASD), Rett syndrome (RTT), and fragile X syndrome (FXS) using retrospective video analysis (RVA) during the first two years of life. Electronic databases were systematically searched and a total of 23 studies were selected. These studies were then categorised according to whether children were later diagnosed with ASD (13 studies), RTT (8 studies), or FXS (2 studies), and then described in terms of (a) participant characteristics, (b) control group characteristics, (c) video footage, (d) behaviours analysed, and (e) main findings...
March 2018: Advances in neurodevelopmental disorders
https://www.readbyqxmd.com/read/29773535/should-patients-with-ductal-carcinoma-in-situ-be-treated-with-adjuvant-whole-breast-radiotherapy-after-breast-conservation-surgery
#8
Jessamy Bagenal, Nicola Roche, Gill Ross, Anna Kirby, David Dodwell
No abstract text is available yet for this article.
May 17, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29767684/ultrasensitive-hiv-1-viral-load-as-a-marker-of-treatment-choice-for-simplification-strategies
#9
Sidonie Lambert-Niclot, Maxime Grude, Jean-Luc Meynard, Anne-Geneviève Marcelin, Marc-Antoine Valantin, Philippe Flandre, Jacques Izopet, Laetitia Moinot, Vincent Bouteloup, Vincent Calvez, Christine Katlama, Pierre-Marie Girard, Laurence Morand-Joubert
Background: We pooled the results of three randomized trials that compared the efficacy of PI/r monotherapy and standard triple therapy as maintenance therapy and evaluated: 1) the distribution of ultrasensitive viral load (USVL) at week 96 (W96), 2) factors associated with virological success (VL<50 copy/mL) at W96, and 3) factors associated with USVL<1 copy/ml (c/ml) at W96. Methods: Virological failure was defined as two consecutive measurements of HIV-1 RNA viral load >50 copies/mL and was analyzed in intention-to-treat...
May 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29766347/towards-alternative-approaches-for-coupling-of-a-soft-robotic-sleeve-to-the-heart
#10
Markus A Horvath, Claudia E Varela, Eimear B Dolan, William Whyte, David S Monahan, Christopher J Payne, Isaac A Wamala, Nikolay V Vasilyev, Frank A Pigula, David J Mooney, Conor J Walsh, Garry P Duffy, Ellen T Roche
Efficient coupling of soft robotic cardiac assist devices to the external surface of the heart is crucial to augment cardiac function and represents a hurdle to translation of this technology. In this work, we compare various fixation strategies for local and global coupling of a direct cardiac compression sleeve to the heart. For basal fixation, we find that a sutured Velcro band adheres the strongest to the epicardium. Next, we demonstrate that a mesh-based sleeve coupled to the myocardium improves function in an acute porcine heart failure model...
May 15, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29765020/changes-in-genome-organization-of-parasite-specific-gene-families-during-the-plasmodium-transmission-stages
#11
Evelien M Bunnik, Kate B Cook, Nelle Varoquaux, Gayani Batugedara, Jacques Prudhomme, Anthony Cort, Lirong Shi, Chiara Andolina, Leila S Ross, Declan Brady, David A Fidock, Francois Nosten, Rita Tewari, Photini Sinnis, Ferhat Ay, Jean-Philippe Vert, William Stafford Noble, Karine G Le Roch
The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29764220/wide-range-crp-versus-high-sensitivity-crp-on-roche-analyzers-focus-on-low-grade-inflammation-ranges-and-high-sensitivity-cardiac-troponin-t-levels
#12
Denis Monneret, Fouzi Mestari, Shaedah Djiavoudine, Guillaume Bachelot, Maxime Cloison, Françoise Imbert-Bismut, Maguy Bernard, Pierre Hausfater, Jean-Marc Lacorte, Dominique Bonnefont-Rousselot
Wide-range C-reactive protein (wr-CRP) has been proposed as an economical alternative to high-sensitivity C-reactive protein (hs-CRP) for the evaluation of low-grade inflammation-associated cardiovascular risk (LGI-CVR). Concomitant values of serum hs-CRP and plasma wr-CRP ≤5 mg/L, and high-sensitivity cardiac troponin T (hs-cTnT), all assayed on Roche Diagnostics analyzers over a 1.8-year period, were extracted from a hospital laboratory database. Hs-CRP and wr-CRP values were compared (Bland-Altman method; Deming's correlation), then separately classified into low (<1 mg/L), moderate (1-3 mg/L) and high (>3 mg/L) LGI-CVR ranges for agreement test (κ), assessed before and after Deming's regression-based adjustment of wr-CRP (Adj-wr-CRP)...
May 15, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29763574/how-low-can-you-go-analytical-performance-of-five-automated-testosterone-immunoassays
#13
Sonia L La'ulu, Kimberly J Kalp, Joely A Straseski
BACKGROUND: Testosterone is commonly measured using immunoassays, yet concerns with the accuracy and quality of testing by these methods exist, particularly for low testosterone concentrations. Study objectives were to evaluate selective performance characteristics, including functional sensitivity (FS), of 5 automated immunoassays for total testosterone. METHODS: FS, imprecision, assay interference, limit of blank, linearity, and accuracy were assessed using the Abbott ARCHITECT i2000SR , SIEMENS ADVIA Centaur and IMMULITE 2000, Beckman Coulter DxI 800, and Roche MODULAR E170...
May 12, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29762342/humeral-stem-loosening-following-reverse-shoulder-arthroplasty-a-systematic-review-and-meta-analysis
#14
Ben Grey, Reitze N Rodseth, Stephen J Roche
BACKGROUND: Aseptic stem loosening following reverse shoulder arthroplasty (RSA) is an uncommon complication. The timing and the factors contributing to aseptic stem loosening remain poorly understood. METHODS: We performed a systematic review that identified 75 articles; 65 of the included articles were case series (Level-IV evidence), 8 were cohort studies (7 Level III, 1 Level II), and 2 were prospective randomized controlled trials (Level I). A meta-analysis of 1,660 cemented and 805 uncemented RSA stems was performed...
May 15, 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29761346/ethical-dilemmas-in-global-anesthesia-and-surgery
#15
EDITORIAL
Gregory Klar, Julie Zalan, Anthony M Roche, Rachel Phelan
No abstract text is available yet for this article.
May 14, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#16
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29756512/profile-of-roche-s-elecsys-troponin-t-gen-5-stat-blood-test-a-high-sensitivity-cardiac-troponin-assay-for-diagnosing-myocardial-infarction-in-the-emergency-department
#17
Peter A Kavsak, James E Andruchow, Andrew D McRae, Andrew Worster
The Elecsys Troponin T Gen 5 STAT test (distributed in the United States (US) by Roche Diagnostics, Indianapolis, IN) is the first high-sensitivity cardiac troponin test approved for use by the FDA in the US (2017). Areas covered: The test offers clinicians the opportunity for more rapid decision-making for diagnosing myocardial infarction (MI) in the emergency department (ED). The Troponin T Gen 5 STAT test (labeled as TNT-G5ST on the reagent pack) is similar to the Troponin T hs STAT (TNT-HSST) and Troponin T hs (TNT-HS) tests that have been available outside the US since 2009...
May 12, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29753681/quality-of-plasma-samples-and-bd-vacutainer-barricor-tubes-effects-of-centrifugation
#18
Andrea Padoan, Martina Zaninotto, Elisa Piva, Laura Sciacovelli, Ada Aita, Adriano Tasinato, Mario Plebani
BACKGROUNDS: The BD Vacutainer ® Barricor™ Plasma collection tube (BD Barricors) uses an innovative non-gel separation method. This study compared the plasma residual cell count (PRCC) obtained from BD Barricor and from BD PST II plasma tubes. METHODS: Four BD Barricors and one BD PST II were collected from 40 donors. BD PST II was centrifuged at 1300g/10 min, while the BD Barricors were centrifuged at 1800g/10 min, 4000g/3 min, 4000g/7 min and 4000g/15 min...
May 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29753124/translation-of-innovative-chemistry-into-screening-libraries-an-exemplar-partnership-from-the-european-lead-factory
#19
Remy Morgentin, Mark Dow, Anthony Aimon, George Karageorgis, Tuomo Kalliokoski, Didier Roche, Stephen Marsden, Adam S Nelson
The identification of high-quality starting points for drug discovery is an enduring challenge in medicinal chemistry. Yet, the chemical space explored in discovery programmes tends be limited by the narrow toolkit of robust methods that are exploited in discovery workflows. The European Lead Factory (ELF) was established in 2013 to boost early-stage drug discovery within Europe. In this Feature, we describe an exemplar partnership that has led to the addition of 21 119 distinctive screening compounds to the ELF Joint European Compound Library...
May 9, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29752705/risk-associated-with-cumulative-oral-glucocorticoid-use-in-patients-with-giant-cell-arteritis-in-real-world-databases-from-the-usa-and-uk
#20
Sara Gale, Jessica C Wilson, Jenny Chia, Huong Trinh, Katie Tuckwell, Neil Collinson, Sophie Dimonaco, Susan Jick, Christoph Meier, Shalini V Mohan, Khaled Sarsour
INTRODUCTION: Treatment of giant cell arteritis (GCA) involves immediate initiation of high-dose glucocorticoid therapy with slow tapering of the dose over many months. Chronic exposure to glucocorticoids is associated with serious comorbidities. The objective of this analysis was to determine the glucocorticoid exposure and risk of glucocorticoid-related adverse events (AEs) in real-world patients with GCA. METHODS: Data from the Truven Healthcare MarketScan® database (from January 1, 2000, to June 30, 2015) and the Clinical Practice Research Datalink (CPRD; from January 1, 1995, to August 31, 2013) were used to retrospectively analyze patients aged ≥ 50 years with GCA in the USA and UK, respectively...
May 11, 2018: Rheumatology and Therapy
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