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https://www.readbyqxmd.com/read/27885340/acute-kidney-injury-in-hematopoietic-stem-cell-transplantation-a-review
#1
REVIEW
Vinod Krishnappa, Mohit Gupta, Gurusidda Manu, Shivani Kwatra, Osei-Tutu Owusu, Rupesh Raina
Hematopoietic stem cell transplantation (HSCT) is a highly effective treatment strategy for lymphoproliferative disorders and bone marrow failure states including aplastic anemia and thalassemia. However, its use has been limited by the increased treatment related complications, including acute kidney injury (AKI) with an incidence ranging from 20% to 73%. AKI after HSCT has been associated with an increased risk of mortality. The incidence of AKI reported in recipients of myeloablative allogeneic transplant is considerably higher in comparison to other subclasses mainly due to use of cyclosporine and development of graft-versus-host disease (GVHD) in allogeneic groups...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27882238/large-uterine-pyomyoma-in-a-perimenopausal-female-a-case-report-and-review-of-50-reported-cases-in-the-literature
#2
Naoyuki Iwahashi, Yasushi Mabuchi, Michihisa Shiro, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino
Pyomyoma is a rare complication, which withoug antibiotics or surgical intervention, may cause sepsis and mortality. The present study reported a case of large uterine pyomyoma in a perimenopausal female. A 53-year-old multigravida woman was referred to the Department of Obstetrics and Gynecology (Wakayama Medical University, Wakayama, Japan) due to progressive abdominal distension. The patient presented with anemia gravis, severe inflammatory reaction and cachexia. Computed tomography revealed a large unilocular mass, 50 cm in size, with an irregular surface and thickened wall, occupying the entire abdomen...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27882237/autologous-tumor-immunizing-devascularization-of-an-invasive-colorectal-cancer-a-case-report-and-literature-review
#3
Pavel Vašek, Josef Krajnik, David J Kopsky, Vladimir Kalina, Marek Frydrych
Colorectal cancer is the third most common cancer. Approximately 20% of patients have at the time of presentation metastasized colorectal cancer, which is incurable in ~80% of cases. The present case report describes a typical case diagnosed with an advanced invasive colorectal adenocarcinoma, with two suspect hypodense lesions in the liver, as revealed by sonography. Judged inoperable for a curative outcome by radical resection, the patient was treated with a novel surgical technique based on stimulating the immune system, termed 'autologous tumor immunizing devascularization' (ATID)...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27879679/hydrostatin-tl1-an-anti-inflammatory-active-peptide-from-the-venom-gland-of-hydrophis-cyanocinctus-in-the-south-china-sea
#4
Ningyuan Wang, Yan Huang, An Li, Hailong Jiang, Jie Wang, Jianzhong Li, Lei Qiu, Ka Li, Yiming Lu
Tumor necrosis factor (TNF)-α is a pleiotropic cytokine with intense pro-inflammatory and immunomodulatory properties, and anti-TNF-α biologics are effective therapies for various inflammatory diseases such as inflammatory bowel disease (IBD) and sepsis. Snake venom, as a traditional Chinese medicine, has been used in the treatment of inflammatory diseases in China for centuries. In this research, we constructed a venom gland T7 phage display library of the sea snake Hydrophis cyanocinctus to screen bioactive compounds that antagonize TNF-α and identified a novel nine-amino-acid peptide, termed hydrostatin-TL1 (H-TL1)...
November 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27878281/etomidate-inhibits-nuclear-factor-%C3%AE%C2%BAb-through-decreased-expression-of-glucocorticoid-receptor-in-septic-rats
#5
Yu Zhang, Ruo-Meng Li, Chun Wang, Na Liu, Shen Lv, Jun-Yu Xiong
The present study aimed to investigate the effect of etomidate administered prior to or following cecal ligation and puncture (CLP) on the expression of glucocorticoid receptor (GR) and lymphocyte apoptosis in septic rats. Right jugular vein catheterization was performed on female Sprague‑Dawley rats under isoflurane anesthesia, and CLP surgery was performed to induce sepsis 3 days following catheterization. The rats were randomly divided into five groups. All groups were infused with 2 ml of either etomidate or 5‰ dimethyl sulfoxide (DMSO) at 1 ml/h for 2 h from 6 h post‑surgery...
November 16, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27878240/sirt1-activator-represses-the-transcription-of-tnf%C3%A2-%C3%AE-in-thp%C3%A2-1-cells-of-a-sepsis-model-via-deacetylation-of-h4k16
#6
Guo-Dong Chen, Wei-Dong Yu, Xiao-Ping Chen
Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, comprising lipopolysaccharide (LPS)‑tolerant THP‑1 cells, was used to investigate whether the SirT1 activator, resveratrol, repressed the transcription of TNF‑α. Chromatin immunoprecipitation and real‑time PCR were used to determine the transcription of the TNF‑α promoter...
November 15, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27859276/urological-complications-after-cystectomy-as-part-of-pelvic-exenteration-are-higher-than-that-after-cystectomy-for-primary-bladder-malignancy
#7
Kilian G M Brown, Michael J Solomon, Edward R Latif, Cherry E Koh, Arthur Vasilaras, David Eisinger, Paul Sved
BACKGROUND: Total cystectomy and subsequent reconstruction of the urinary tract may be required for primary malignancy of the bladder, or in the context of multi-visceral resection for more advanced pelvic tumors. Complications following urinary diversion are a major source of morbidity, particularly in pelvic exenteration (PE) patients. METHODS: All patients who underwent radical cystectomy alone or during PE at a single tertiary referral centre between 2008 and 2014 were reviewed...
November 18, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27855671/giant-duodenal-ulcers-after-neurosurgery-for-brainstem-tumors-that-required-reoperation-for-gastric-disconnection-a-report-of-two-cases
#8
Chihoko Nobori, Kenjiro Kimura, Go Ohira, Ryosuke Amano, Sadaaki Yamazoe, Hiroaki Tanaka, Kentaro Naito, Toshihiro Takami, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Despite the efficacy of pharmacotherapy for gastrointestinal ulcers, severe cases of bleeding or perforation due to gastrointestinal ulcers still occur. Giant duodenal ulcer perforation is an uncommon but difficult-to-manage pathology with a high mortality rate. We report two cases of giant duodenal ulcer perforation after neurosurgery for brainstem tumors that needed reoperation for gastric disconnection because of postoperative leakage and bleeding. CASE PRESENTATION: Both cases had undergone neurosurgery for brainstem tumors, and the patients were in a shock state for several days with peritonitis due to giant duodenal perforation...
November 17, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27843456/a-huge-cystic-retroperitoneal-lymphangioma-presenting-with-back-pain
#9
Mahir Gachabayov, Kubach Kubachev, Elbrus Abdullaev, Valentin Babyshin, Dmitriy Neronov, Abakar Abdullaev
Retroperitoneal lymphangioma is a rare location and type of benign abdominal tumors. The clinical presentation of this rare disease is nonspecific, ranging from abdominal distention to sepsis. Here we present a 73-year-old female patient with 3-month history of back pain. USG and CT revealed a huge cystic mass which was surgically excised and appeared to be lymphangioma on histopathology.
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27837177/protection-of-resveratrol-on-acute-kidney-injury-in-septic-rats
#10
Y Gan, S Tao, D Cao, H Xie, Q Zeng
AIM: The aim of the study is to investigate protective effect of resveratrol (Res) on acute kidney injury (AKI) in sepsis. METHODS: Rats in sham group received sham operation; in sham + Res received sham operation and Res (3 mg/kg); in cecal ligation and puncture (CLP) established as sepsis; in CLP + Res (3 mg/kg) with sepsis and Res (3 mg/kg); and in CLP + Res (10 mg/kg) with sepsis and Res (10 mg/kg). Survival rate, serum indexes, inflammatory factors, NF-κB-P65, and SIRT1 were detected...
November 11, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27822733/-cutaneous-manifestations-in-renal-diseases
#11
M Schmid-Simbeck, A Udvardi, B Volc-Platzer
In addition to general skin changes like pallor or dryness and the frequent, often excruciating nephrogenic pruritus, specific diseases in patients with renal failure may occur. Acquired perforating dermatoses are usually also highly pruritic. Calciphylaxis is a severe disease with poor prognosis. Nonhealing wounds with superinfection and progression to sepsis are characteristic. Bullous lesions can be caused by disturbances in porphyrin metabolism. Nephrogenic systemic fibrosis is a disease which was first described in 2000...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27807512/lipopolysaccharide-induces-human-pulmonary-micro-vascular-endothelial-apoptosis-via-the-yap-signaling-pathway
#12
Lei Yi, Xiaoqin Huang, Feng Guo, Zengding Zhou, Mengling Chang, Jiajun Tang, Jingning Huan
Gram-negative bacterial lipopolysaccharide (LPS) induces a pathologic increase in lung vascular leakage under septic conditions. LPS-induced human pulmonary micro-vascular endothelial cell (HPMEC) apoptosis launches and aggravates micro-vascular hyper-permeability and acute lung injury (ALI). Previous studies show that the activation of intrinsic apoptotic pathway is vital for LPS-induced EC apoptosis. Yes-associated protein (YAP) has been reported to positively regulate intrinsic apoptotic pathway in tumor cells apoptosis...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27801365/oxidative-stress-parameters-and-inflammatory-and-immune-mediators-as-markers-of-the-severity-of-sepsis
#13
Isil Bavunoglu, Habibe Genc, Dildar Konukoglu, Hayriye Cicekci, Volkan Sozer, Remise Gelisgen, Hafize Uzun
INTRODUCTION: Sepsis is a complex inflammatory syndrome with diverse etiology and wide spectrum of severity. The aim of this study was to investigate whether inflammatory mediators, in comparison with oxidative parameters, are associated with severity of sepsis. METHODOLOGY: Plasma neopterin, adenosine deaminase (ADA), vascular cell adhesion molecule (VCAM), intracellular adhesion molecule (ICAM), interleukin (IL)-1, IL-6, and tumor necrosis factor alpha (TNF-α), as inflammatory mediators, and serum nitric oxide (NOx), nitrotyrosine (NT), oxidized LDL (oxLDL) levels, serum paraoxonase 1 (PON1) activity, and erythrocyte glutathione (GSH) levels as oxidative stress parameters of 12 patients with mild sepsis, 25 patients with severe sepsis, and 20 healthy control subjects were evaluated...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27795864/histiocytic-sarcoma-in-a-kidney-transplant-patient-a-case-report-and-review-of-the-literature
#14
Maressa Pollen, Siraj El Jamal, Jack Lewin, Varsha Manucha
Objective. Histiocytic sarcoma (HS) is an aggressive neoplasm with only limited number of reported series of cases and rare case reports of occurrence as a posttransplant neoplastic disorder. The etiology and pathogenesis of the disease is unknown and the optimal treatment is still under investigation. We describe an unusual case of HS in a patient with a remote history of kidney transplant. Method and Results. A 54-year-old male with a remote history of renal transplantation under maintenance immunosuppression presented with features of sepsis...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27788614/study-of-the-role-of-tumor-necrosis-factor-%C3%AE-%C3%A2-308%C3%A2-g-a-and-interleukin-10-1082-g-a-polymorphisms-as-potential-risk-factors-to-acute-kidney-injury-in-patients-with-severe-sepsis-using-high-resolution-melting-curve-analysis
#15
Doaa I Hashad, Eman T Elsayed, Tamer A Helmy, Samier M Elawady
RATIONAL: Septic acute kidney injury (AKI) is a prevalent complication in intensive care units with an increased incidence of complications. OBJECTIVE: The aim of the present study was to assess the use of high-resolution melting curve (HRM) analysis in investigating whether the genetic polymorphisms; -308 G/A of tumor necrosis factor-α (TNF-α), and -1082 G /A of Interleukin-10 (IL-10) genes may predispose patients diagnosed with severe sepsis to the development of AKI...
October 27, 2016: Renal Failure
https://www.readbyqxmd.com/read/27787388/hydrocephalus-secondary-to-chemotherapy-in-a-case-of-prenatally-diagnosed-giant-immature-grade-3-sacrococcygeal-teratoma-a-case-report-and-literature-review
#16
Ioan Sarbu, Demetra Socolov, Razvan Socolov, Ingrith Miron, Mioara Trandafirescu, Smaranda Diaconescu, Carmen Iulia Ciongradi
INTRODUCTION: Sacrococcygeal teratoma (SCT) is a rare tumor in the general population, arising from multipotent stem cells. Whereas most of the cases diagnosed postnatally have good prognosis, the rate of mortality and morbidities associated with prenatally diagnosed SCT remain high, with a reported mortality rate of 30% to 50%. The outcome of fetal SCT can be unpredictable, with some cases with slow growth during fetal life, whereas others grow rapidly, causing multiple complications; also, some of these tumor will develop triggering fetal (preterm delivery, high-output cardiac failure, hydrops fetalis, intrauterine death) or maternal complications (distocia, placentomegaly, maternal mirror syndrome-preeclampsia)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27785087/adiponectin-treatment-attenuates-inflammatory-response-during-early-sepsis-in-obese-mice
#17
XianFeng Wang, Nancy L Buechler, Barbara K Yoza, Charles E McCall, Vidula Vachharajani
BACKGROUND: Morbid obesity increases the cost of care in critically ill patients. Sepsis is the leading cause of death in noncoronary intensive care units. Circulating cell-endothelial cell interactions in microcirculation are the rate-determining factors in any inflammation; obesity increases these interactions further. Adiponectin deficiency is implicated in increased cardiovascular risk in obese patients. We have shown that adiponectin deficiency increases microvascular dysfunction in early sepsis...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27783140/lower-limb-reconstruction-in-tumor-patients-using-modular-silver-coated-megaprostheses-with-regard-to-perimegaprosthetic-joint-infection-a-case-series-including-100-patients-and-review-of-the-literature
#18
J Schmolders, S Koob, P Schepers, P H Pennekamp, S Gravius, D C Wirtz, R Placzek, A C Strauss
PURPOSE AND OBJECTIVE: Bone resection regarding adequate surgical margins is the treatment of choice for malignant bone tumors. In the case of metastasis-related complications, so-called skeletal-related events, it is highly important to achieve pain relief and a stable joint situation to re-mobilize the patients immediately following surgery. To bridge the often large osseous defect zones after tumor resection, both cemented and uncemented modular endoprosthetic systems are widely used...
October 25, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27779675/resveratrol-alleviates-sepsis%C3%A2-induced-myocardial-injury-in-rats-by-suppressing-neutrophil-accumulation-the-induction-of-tnf%C3%A2-%C3%AE-and-myocardial-apoptosis-via-activation-of-sirt1
#19
Rui An, Lei Zhao, Jian Xu, Cong Xi, Haixun Li, Guohong Shen, Wei Zhang, Shumiao Zhang, Lijun Sun
Sepsis is a severe inflammatory response to systemic infection that frequently affects the myocardium. Previous studies have suggested that resveratrol (RESV) is protective in sepsis. The present study aimed to investigate the role of sirtuin 1 (Sirt1) signaling in the protective effect of intraperitoneally administered RESV against sepsis‑induced myocardial injury. Cecal ligation and puncture, or a sham operation, were performed in male Sprague‑Dawley rats, and the levels of tumor necrosis factor (TNF)‑α and myeloperoxidase (MPO) were assessed by ELISA and an MPO activity kit, respectively...
October 19, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27778275/anti-septic-effects-of-pelargonidin-on-hmgb1-induced-responses-in-vitro-and-in-vivo
#20
Gahee Min, Sae-Kwang Ku, Mi Seon Park, Tae-Joo Park, Hyun-Shik Lee, Jong-Sup Bae
A certain nucleosomal protein-high mobility group box-1 (HMGB1)-has recently been established as a late mediator of sepsis, with a relatively wide therapeutic window for pharmacological intervention. Pelargonidin (PEL) is a well-known red pigment found in plants; it has important biological activities that are potentially beneficial for human health. In the present study, we investigated whether PEL can modulate HMGB1-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice...
October 24, 2016: Archives of Pharmacal Research
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