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https://www.readbyqxmd.com/read/28922758/the-role-of-arabidopsis-aldehyde-dehydrogenase-genes-in-response-to-high-temperature-and-stress-combinations
#1
Junyi Zhao, Tagnon D Missihoun, Dorothea Bartels
Aldehyde dehydrogenases (ALDH) are a family of enzymes that are involved in plant metabolism and contribute to aldehyde homeostasis to eliminate toxic aldehydes. The ALDH enzymes produce NADPH and NADH in their enzymatic reactions and thus contribute to balancing redox equivalents. Previous studies showed that Arabidopsis ALDH genes are expressed in response to high salinity, dehydration, oxidative stress, or heavy metals, suggesting important roles in environmental adaptation. However, the role of ALDH genes in high temperature and stress combinations (heat stress combined with dehydration, wounding, or salt stress) is unclear...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922729/lithium-induced-oxidative-damage-and-inflammation-in-the-rat-s-heart-protective-effect-of-grape-seed-and-skin-extract
#2
Ali Mezni, Hanène Aoua, Olfa Khazri, Ferid Limam, Ezzeddine Aouani
Lithium (Li) is a relevant mood stabilizer metal for the treatment of bipolar disorder (BD), as it protects from both depression and mania and reduces the risk of suicide. However, Lihas some clinical concerns as a narrow therapeutic index requiring routine monitoring of the serum level. The present study was designed to analyze the cardio-toxic side effect of Li and the ability of grape seed and skin extract (GSSE) to protect the heart against such toxicity. After 30days of exposure to Li (0, 2, 5 and 100mg/kg bw) and prevention with GSSE (4000mg/kg bw), rats were killed by decapitation and their heart processed for Li-induced oxidative stress...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28922724/oyster-ostrea-plicatula-gmelin-polysaccharides-intervention-ameliorates-cyclophosphamide-induced-genotoxicity-and-hepatotoxicity-in-mice-via-the-nrf2-are-pathway
#3
Shuting Lin, Gengxin Hao, Min Long, Fei Lai, Qingqin Li, Yongmei Xiong, Yan Tian, Dong Lai
In this study, we explored the protective effects of oyster (Ostrea plicatula Gmelin) polysaccharides (OPS) against genotoxicity and liver injury induced by cyclophosphamide (CP) in BALB/c mice. OPS was administered to mice at doses of 100 and 200mg/kg for 7 consecutive days, then 50mg/kg CP was injected via abdomen. Then mice were sacrificed and samples were collected. Bone marrow micronuclei (MN) and polychromatic erythrocytes (PCE): normochromatic erythrocytes (NCE) ratio were calculated to evaluate CP induced genetic toxicity...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28922497/mutual-independence-of-alkaline-and-calcium-mediated-signalling-in-aspergillus-fumigatus-refutes-the-existence-of-a-conserved-druggable-signalling-nexus
#4
Omar Loss, Margherita Bertuzzi, Yu Yan, Natalie Fedorova, Bethany L McCann, Darius Armstrong-James, Eduardo A Espeso, Nick D Read, William C Nierman, Elaine M Bignell
Functional coupling of calcium- and alkaline responsive signalling occurs in multiple fungi to afford efficient cation homeostasis. Host microenvironments exert alkaline stress and potentially toxic concentrations of Ca(2+) , such that highly conserved regulators of both calcium- (Crz) and pH- (PacC/Rim) responsive signalling are crucial for fungal pathogenicity. Drugs targeting calcineurin are potent antifungal agents but also perturb human immunity thereby negating their use as anti-infectives, abrogation of alkaline signalling has therefore been postulated as an adjunctive antifungal strategy...
September 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28922384/effects-of-salinity-and-drought-on-growth-ionic-relations-compatible-solutes-and-activation-of-antioxidant-systems-in-oleander-nerium-oleander-l
#5
Dinesh Kumar, Mohamad Al Hassan, Miguel A Naranjo, Veena Agrawal, Monica Boscaiu, Oscar Vicente
Nerium oleander is an ornamental species of high aesthetic value, grown in arid and semi-arid regions because of its drought tolerance, which is also considered as relatively resistant to salt; yet the biochemical and molecular mechanisms underlying oleander's stress tolerance remain largely unknown. To investigate these mechanisms, one-year-old oleander seedlings were exposed to 15 and 30 days of treatment with increasing salt concentrations, up to 800 mM NaCl, and to complete withholding of irrigation; growth parameters and biochemical markers characteristic of conserved stress-response pathways were then determined in stressed and control plants...
2017: PloS One
https://www.readbyqxmd.com/read/28920707/in-vitro-and-in-vivo-studies-of-allium-sativum-extract-against-deltamethrin-induced-oxidative-stress-in-rats-brain-and-kidney
#6
Marwa Ncir, Mongi Saoudi, Hanen Sellami, Fatma Rahmouni, Amina Lahyani, Fatma Makni Ayadi, Abdelfattah El Feki, Mohamed Salah Allagui
The present study investigated the in vitro and the in vivo antioxidant capacities of Allium sativum (garlic) extract against deltamethrin-induced oxidative damage in rat's brain and kidney. The in vitro result showed that highest extraction yield was achieved with methanol (20.08%). Among the tested extracts, the methanol extract exhibited the highest total phenolic, flavonoids contents and antioxidant activity. The in vivo results showed that deltamethrin treatment caused an increase of the acetylcholinesterase level (AChE) in brain and plasma, the brain and kidney conjugated dienes and lipid peroxidation (LPO) levels as compared to control group...
September 18, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28920632/acute-cardiotoxicity-induced-by-doxorubicin-in-right-ventricle-is-associated-with-increase-of-oxidative-stress-and-apoptosis-in-rats
#7
N Anghel, H Herman, C Balta, M Rosu, M S Stan, D Nita, A Ivan, Z Galajda, A Ardelean, A Dinischiotu, A Hermenean
Doxorubicin (DOX) is one of the most effective chemotherapeutic agents, but its efficiency is seriously limited by the risk of developing cardiomyopathy. The most recognized cardiotoxic effect is left ventricular (LF) dysfunction, but MRI and echocardiography data demonstrated significant right ventricle (RV) function impairment. In order to clarify this aspect, the present study investigated the potential of DOX to induce acute RV cardiotoxicity at the same time as LV impairment. Rats were intraperitoneally (i...
September 18, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28920150/molecular-basis-of-cd-2-stress-response-in-candida-tropicalis
#8
Zaman Khan, Abdul Rehman, Muhammad Atif Nisar, Saima Zafar, Syed Zajif Hussain, Inga Zerr, Irshad Hussain, Muhammad Waseem, Muhammad Arif
This study examines the bioremediation potential and cadmium-induced cellular response on a molecular level in Candida tropicalis 3Aer. Spectroscopic analysis clearly illustrated the involvement of yeast cell wall components in biosorption. Cadmium bioaccumulation was confirmed by TEM, SEM, and EDX examination. TEM images revealed extracellular as well as cytoplasmic and vacuolar cadmium nanoparticle formation, further validated by presence of ycf1 gene and increased biosynthesis of GSH under cadmium stress...
September 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28919881/genomic-and-transcriptomic-analysis-of-growth-supporting-dehalogenation-of-chlorinated-methanes-in-methylobacterium
#9
Pauline Chaignaud, Bruno Maucourt, Marion Weiman, Adriana Alberti, Steffen Kolb, Stéphane Cruveiller, Stéphane Vuilleumier, Françoise Bringel
Bacterial adaptation to growth with toxic halogenated chemicals was explored in the context of methylotrophic metabolism of Methylobacterium extorquens, by comparing strains CM4 and DM4, which show robust growth with chloromethane and dichloromethane, respectively. Dehalogenation of chlorinated methanes initiates growth-supporting degradation, with intracellular release of protons and chloride ions in both cases. The core, variable and strain-specific genomes of strains CM4 and DM4 were defined by comparison with genomes of non-dechlorinating strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28919745/dose-and-time-effect-of-cdte-quantum-dots-on-antioxidant-capacities-of-the-liver-and-kidneys-in-mice
#10
Jilong Wang, Hubo Sun, Peijun Meng, Mengmeng Wang, Mi Tian, Yamin Xiong, Xueying Zhang, Peili Huang
Although quantum dot (QD)-induced toxicity occurs due to free radicals, generation of oxidative stress mediated by reactive oxygen species (ROS) formation is considered an important mechanism. However, free radical mechanisms are essentially difficult to elucidate at the molecular level because most biologically relevant free radicals are highly reactive and short-lived, making them difficult to directly detect, especially in vivo. Antioxidants play an important role in preventing or, in most cases, limiting the damage caused by ROS...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919690/subchronic-toxicity-of-nile-tilapia-with-different-exposure-routes-to-microcystis-aeruginosa-histopathology-liver-functions-and-oxidative-stress-biomarkers
#11
H M R Abdel-Latif, A M Abou Khashaba
BACKGROUND: Toxic cyanobacterial blooms (Microcystis aeruginosa contains microcystins [MCs]) have been reported to induce clinicopathological alterations as well as different oxidative stress in aquatic biota. AIM: Three-week subchronic exposure experiment was carried out on Nile tilapia, to determine their effects on fish behavior, tissues, liver functions, antioxidant enzymes, and lipid peroxidation. MATERIALS AND METHODS: Fish were exposed to four main treatments; orally fed diet plus toxic cells of M...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28919516/time-dependent-effects-of-perfluorinated-compounds-on-viability-in-cerebellar-granule-neurons-dependence-on-carbon-chain-length-and-functional-group-attached
#12
Hanne Friis Berntsen, Cesilie Granum Bjørklund, Jean-Nicolas Audinot, Tim Hofer, Steven Verhaegen, Esther Lentzen, Arno Christian Gutleb, Erik Ropstad
The toxicity of long chained perfluoroalkyl acids (PFAAs) has previously been reported to be related to the length of the perfluorinated carbon chain and functional group attached. In the present study, we compared the cytotoxicity of six PFAAs, using primary cultures of rat cerebellar granule neurons (CGNs). Two perfluoroalkyl sulfonic acids (PFSAs, chain length C6 and C8) and four perfluoroalkyl carboxylic acids (PFCAs, chain length C8-C11) were studied. These PFAAs have been detected in human blood and the brain tissue of mammals...
September 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28919410/tetrabromobisphenol-a-disturbs-zinc-homeostasis-in-cultured-cerebellar-granule-cells-a-dual-role-in-neurotoxicity
#13
Elzbieta Zieminska, Anna Ruszczynska, Jerzy W Lazarewicz
The brominated flame retardant tetrabromobisphenol A (TBBPA) has recognized neurotoxic properties mediated by intracellular Ca(2+) imbalance and oxidative stress. Although these factors are known to trigger the release of Zn(2+) from intracellular stores, the effects of TBBPA on Zn(2+) homeostasis in neurons and the role of Zn(2+)in TBBPA neurotoxicity have not yet been studied. Therefore, we investigated zinc transients in primary cultures of rat cerebellar granule cells and assessed their involvement in TBBPA neurotoxicity...
September 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28918453/furan-induced-ovarian-damage-in-non-diabetic-and-diabetic-rats-and-cellular-protective-role-of-lycopene
#14
Semra Uçar, Dilek Pandir
PURPOSE: In our work, furan, lycopene, and furan + lycopene treatments were applied to non-diabetic and diabetic female rats via gavage. METHODS: Ovarian tissue alterations with histopathology, immunohistochemistry, malondialdehyde levels, oxidative stress parameters such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and harmful effect on ovarian tissue DNA were evaluated in all groups for 28 days. RESULTS: Furan caused the changes histological, ovarian cell's DNA structure, malondialdehyde levels, antioxidant enzymes activities as in a statistically significant manner in each group...
September 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28918354/indium-iii-induces-isolated-mitochondrial-permeability-transition-by-inhibiting-proton-influx-and-triggering-oxidative-stress
#15
Lian Yuan, Jiaqi Zhang, Yujiao Liu, Jie Zhao, Fenglei Jiang, Yi Liu
While Indium's toxicity to organs is realized, its effects on mitochondria are still under investigation. Mitochondrial permeability transition (MPT) is widely accepted in mitochondrial dysfunction approaches and its importance in metal-induced mitochondrial degradation has been proposed. Since mitochondria are respiratory organelles, their interaction with free In(3+) is analyzed to access structural and functional changes. Spectral methods and multimode plate reader was used to detect mitochondrial swelling, membrane potential, membrane fluidity, and inner membrane permeability...
September 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28918124/polyphenols-reported-to-shift-apap-induced-changes-in-mapk-signaling-and-toxicity-outcomes
#16
REVIEW
Ngoc Uy Nguyen, Brendan David Stamper
Due to its widespread availability, acetaminophen (APAP) is the leading cause for drug-induced liver injury in many countries including United States and United Kingdom. When used as recommended, APAP is relatively safe. However, in overdose cases, increased metabolism of APAP to N-acetyl-para-benzoquinoneimine (NAPQI), a reactive metabolite, leads to glutathione (GSH) depletion, oxidative stress, and cellular injury. Throughout this process, a variety of factors play important roles in propagating toxicity, including c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family...
September 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28917945/toxic-responses-of-perna-viridis-hepatopancreas-exposed-to-ddt-benzo-a-pyrene-and-their-mixture-uncovered-by-itraq-based-proteomics-and-nmr-based-metabolomics
#17
Qinqin Song, Hailong Zhou, Qian Han, Xiaoping Diao
Dichlorodiphenyltrichloroethane (DDT) and benzo(a)pyrene (BaP) are environmental estrogens (EEs) that are ubiquitous in the marine environment. In the present study, we integrated isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic and nuclear magnetic resonance (NMR)-based metabolomic approaches to explore the toxic responses of green mussel hepatopancreas exposed to DDT (10μg/L), BaP (10μg/L) and their mixture. The metabolic responses indicated that BaP primarily disturbed energy metabolism and osmotic regulation in the hepatopancreas of the male green mussel P...
September 11, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28917816/crystalline-phase-dependent-eco-toxicity-of-titania-nanoparticles-to%C3%A2-freshwater-biofilms
#18
Kun Li, Jin Qian, Peifang Wang, Chao Wang, Jingjing Liu, Xin Tian, Bianhe Lu, Mengmeng Shen
The potential toxic impacts of different crystal phases of titania nanoparticles (TNPs) on freshwater biofilms, especially under ultraviolet C irradiation (UVC), are unknown. Here, adverse impacts of three phases (anatase, rutile, and P25, 50 mg L(-1) respectively) with UVC irradiation (An-UV, Ru-UV, and P25-UV) on freshwater biofilms were conducted. Characterization experiments revealed that rutile TNPs had a higher water environment stability than anatase and P25 TNPs, possessing a stronger photocatalytic activity under UVC irradiation...
September 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28917143/glutathione-induced-alleviation-of-cadmium-toxicity-in-zea-mays
#19
Mei Li, Pengfei Hao, Fangbin Cao
Glutathione (GSH) is known to alleviate cadmium (Cd) stress in many plant species. However, the comprehensive mechanisms responsible for this effect in maize are still need more investigation. Here, a combination of physiological and molecular approaches was utilized in GSH-Cd treated maize seedlings, which revealed that GSH reversed the adverse effects of Cd, as reflected by plant growth, plant hormones, vacuole, stoma development, gene expression, etc. Plant growth, root cell viability, photosynthetic capacity, redox equilibrium, and cell ultrastructure recovery following GSH treatment, coupled with the strong up-regulation of Cd tolerance-related genes (e...
September 8, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28917102/performance-evaluation-and-microbial-community-shift-of-a-sequencing-batch-reactor-under-silica-nanoparticles-stress
#20
Shanshan Li, Shijiang Gao, Sen Wang, Bingrui Ma, Liang Guo, Zhiwei Li, Qiaoyan Xu, Zonglian She, Mengchun Gao, Yangguo Zhao, Feng Gao, Chunji Jin
The performance, microbial community and enzymatic activity of a sequencing batch reactor (SBR) were evaluated at different silica nanoparticles (SiO2 NPs) concentrations. SiO2 NPs concentration at 5-30mg/L had a slight inhibitory impact on the nitrogen and COD removals, whereas the phosphorus removal was obviously inhibited at 30mg/L SiO2 NPs. The rates of nitrification, nitrite reduction and phosphorus removal decreased with the increase of SiO2 NPs concentration. The nitrate reduction rate decreased at less than 5mg/L SiO2 NPs and subsequently showed an increase at 10-30mg/L SiO2 NPs...
September 6, 2017: Bioresource Technology
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