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JOURNAL ARTICLE
Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ances
BACKGROUND: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. Studies including these cohorts could, therefore, improve our understanding of the early pathogenesis of Alzheimer's disease and be useful when designing preventive interventions targeted at disease pathology or when planning clinical trials...
May 2024: Lancet Neurology
#2
JOURNAL ARTICLE
Agneta Nordberg
No abstract text is available yet for this article.
May 2024: Lancet Neurology
#3
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: The burden of neurological conditions in north Africa and the Middle East is increasing. We aimed to assess the changes in the burden of neurological conditions in this super-region to aid with future decision making. METHODS: In this analysis of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 data, we examined temporal trends of disability-adjusted life-years (DALYs; deaths and disabilities combined), deaths, incident cases, and prevalent cases of 14 major neurological conditions and eight subtypes in 21 countries in the north Africa and the Middle East super-region...
April 8, 2024: Lancet Global Health
#4
JOURNAL ARTICLE
Shahram Oveisgharan, Tianhao Wang, Lisa L Barnes, Julie A Schneider, David A Bennett, Aron S Buchman
BACKGROUND: Many studies have reported that impaired gait precedes cognitive impairment in older people. We aimed to characterise the time course of cognitive and motor decline in older individuals and the association of these declines with the pathologies of Alzheimer's disease and related dementias. METHODS: This multicohort study used data from three community-based cohort studies (Religious Orders Study, Rush Memory and Aging Project, and Minority Aging Research Study, all in the USA)...
April 3, 2024: The Lancet. Healthy longevity
#5
JOURNAL ARTICLE
Irene Cumplido-Mayoral, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Armand González-Escalante, Federica Anastasi, Marta Milà-Alomà, David López-Martos, Muge Akinci, Carles Falcón, Mahnaz Shekari, Raffaele Cacciaglia, Eider M Arenaza-Urquijo, Carolina Minguillón, Karine Fauria, José Luis Molinuevo, Marc Suárez-Calvet, Oriol Grau-Rivera, Verónica Vilaplana, Juan Domingo Gispert
BACKGROUND: Neuroimaging-based brain-age delta has been shown to be a mediator linking cardiovascular risk factors to cognitive function. We aimed to assess the mediating role of brain-age delta in the association between modifiable risk factors of dementia and longitudinal cognitive decline in middle-aged and older individuals who are asymptomatic, stratified by Alzheimer's disease pathology. We also explored whether the mediation effect is specific to cognitive domain. METHODS: In this cohort study, we included participants from the ALFA+ cohort aged between 45 years and 65 years who were cognitively unimpaired and who had available structural MRI, cerebrospinal fluid β-amyloid (Aβ)42 and Aβ40 measurements obtained within 1 year of each other, modifiable risk factors assessment, and cognitive evaluation over 3 years...
April 2024: The Lancet. Healthy longevity
#6
JOURNAL ARTICLE
Richard G Booth, Monidipa Dasgupta, Cheryl Forchuk, Salimah Z Shariff
BACKGROUND: Cognitive decline in people experiencing homelessness is an increasingly recognised issue. We compared the prevalence of dementia among people experiencing homelessness to housed individuals in the general population and those living in low-income neighbourhoods. METHODS: We conducted a population-based, cross-sectional, comparative analysis using linked health-care administrative data from Ontario, Canada. We included individuals aged 45 years or older on Jan 1, 2019, who visited hospital-based ambulatory care (eg, emergency department), were hospitalised, or visited a community health centre in 2019; and identified people experiencing homelessness if they had one or more health-care records with an indication of homelessness or unstable housing...
April 2024: Lancet. Public Health
#7
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage...
March 5, 2024: Lancet Neurology
#8
JOURNAL ARTICLE
Aaron Reuben, Leah S Richmond-Rakerd, Barry Milne, Devesh Shah, Amber Pearson, Sean Hogan, David Ireland, Ross Keenan, Annchen R Knodt, Tracy Melzer, Richie Poulton, Sandhya Ramrakha, Ethan T Whitman, Ahmad R Hariri, Terrie E Moffitt, Avshalom Caspi
INTRODUCTION: Dementia risk may be elevated in socioeconomically disadvantaged neighborhoods. Reasons for this remain unclear, and this elevation has yet to be shown at a national population level. METHODS: We tested whether dementia was more prevalent in disadvantaged neighborhoods across the New Zealand population (N = 1.41 million analytic sample) over a 20-year observation. We then tested whether premorbid dementia risk factors and MRI-measured brain-structure antecedents were more prevalent among midlife residents of disadvantaged neighborhoods in a population-representative NZ-birth-cohort (N = 938 analytic sample)...
March 14, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#9
JOURNAL ARTICLE
Scott T Chiesa, Tom Norris, Victoria Garfield, Marcus Richards, Alun D Hughes
BACKGROUND: Excess bodyweight (BMI >25 kg/m2 ) in midlife (age 40-65 years) has been linked to future cognitive decline and an increased risk of dementia. Whether chronic exposure to excess bodyweight in the early decades of life (<40 years) is associated with compromised cognitive function by midlife, however, remains unclear. This study therefore aimed to test potential bidirectional direct and indirect pathways linking cumulative exposure to excess bodyweight and cognitive function in the early decades of life...
March 2024: The Lancet. Healthy longevity
#10
JOURNAL ARTICLE
Jose A Adams, Arkady Uryash, Jose R Lopez
Alzheimer's disease (AD) affects more than 40 million people worldwide and is the leading cause of dementia. This disease is a challenge for both patients and caregivers and puts a significant strain on the global healthcare system. To address this issue, the Lancet Commission recommends focusing on reducing modifiable lifestyle risk factors such as hypertension, diabetes, and physical inactivity. Passive pulsatile shear stress (PPSS) interventions, which use devices like whole-body periodic acceleration, periodic acceleration along the Z-axis (pGz), and the Jogging Device, have shown significant systemic and cellular effects in preclinical and clinical models which address these modifiable risks factors...
February 22, 2024: Journal of Alzheimer's Disease: JAD
#11
REVIEW
Giovanni B Frisoni, Cristina Festari, Federico Massa, Matteo Cotta Ramusino, Stefania Orini, Dag Aarsland, Federica Agosta, Claudio Babiloni, Barbara Borroni, Stefano F Cappa, Kristian S Frederiksen, Lutz Froelich, Valentina Garibotto, Alexander Haliassos, Frank Jessen, Anita Kamondi, Roy Pc Kessels, Silvia D Morbelli, John T O'Brien, Markus Otto, Armand Perret-Liaudet, Francesca B Pizzini, Mathieu Vandenbulcke, Ritva Vanninen, Frans Verhey, Meike W Vernooij, Tarek Yousry, Mercè Boada Rovira, Bruno Dubois, Jean Georges, Oskar Hansson, Craig W Ritchie, Philip Scheltens, Wiesje M van der Flier, Flavio Nobili
The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease emphasises the need for consensus recommendations on the rational use of biomarkers to diagnose people with suspected neurocognitive disorders in memory clinics. Most available recommendations and guidelines are either disease-centred or biomarker-centred. A European multidisciplinary taskforce consisting of 22 experts from 11 European scientific societies set out to define the first patient-centred diagnostic workflow that aims to prioritise testing for available biomarkers in individuals attending memory clinics...
March 2024: Lancet Neurology
#12
RANDOMIZED CONTROLLED TRIAL
Claudia Cooper, Victoria Vickerstaff, Julie Barber, Rosemary Phillips, Margaret Ogden, Kate Walters, Iain Lang, Penny Rapaport, Vasiliki Orgeta, Kenneth Rockwood, Sara Banks, Marina Palomo, Laurie T Butler, Kathyrn Lord, Gill Livingston, Sube Banerjee, Jill Manthorpe, Briony Dow, Juanita Hoe, Rachael Hunter, Quincy Samus, Jessica Budgett
BACKGROUND: Although national guidelines recommend that everyone with dementia receives personalised post-diagnostic support, few do. Unlike previous interventions that improved personalised outcomes in people with dementia, the NIDUS-Family intervention is fully manualised and deliverable by trained and supervised, non-clinical facilitators. We aimed to investigate the effectiveness of home-based goal setting plus NIDUS-Family in supporting the attainment of personalised goals set by people with dementia and their carers...
February 2024: The Lancet. Healthy longevity
#13
JOURNAL ARTICLE
Nicola Coley, Henrik Zetterberg, Christelle Cantet, Sophie Guyonnet, Nicholas J Ashton, Bruno Vellas, Kaj Blennow, Sandrine Andrieu
BACKGROUND: It is unknown whether multidomain interventions, which might preserve late-life cognition, affect Alzheimer's disease pathology. Previous studies measured cerebrospinal fluid and imaging Alzheimer's disease biomarkers in small subsamples of multidomain trial participants. Newly developed assays enable the measurement of blood-based Alzheimer's disease biomarkers in larger samples. We aimed to assess whether plasma tau phosphorylated at threonine 181 (p-tau181) was able to detect or predict 3-year multidomain intervention effects...
February 2024: The Lancet. Healthy longevity
#14
JOURNAL ARTICLE
Qing-Wen Ren, Tiew-Hwa Katherine Teng, Yi-Kei Tse, Christopher Tze Wei Tsang, Si-Yeung Yu, Mei-Zhen Wu, Xin-Li Li, Denise Hung, Hung-Fat Tse, Carolyn S P Lam, Kai-Hang Yiu
BACKGROUND: Heart failure (HF) and dementia frequently co-exist with shared pathological mechanisms and risk factors. Our study aims to investigate the association between statin therapy and the risks of dementia and its subtypes among patients with HF. METHODS: The Hong Kong Clinical Data Analysis and Reporting System database was interrogated to identify patients with incident HF diagnosis from 2004 to 2018, using ICD 9/ICD 10 codes. Inverse probability of treatment weighting (IPTW) was used to balance baseline covariates between statin users (N = 54,004) and non-users (N = 50,291)...
March 2024: The Lancet Regional Health. Western Pacific
#15
JOURNAL ARTICLE
Marianne Chapleau, Renaud La Joie, Keir Yong, Federica Agosta, Isabel Elaine Allen, Liana Apostolova, John Best, Baayla D C Boon, Sebastian Crutch, Massimo Filippi, Giorgio Giulio Fumagalli, Daniela Galimberti, Jonathan Graff-Radford, Lea T Grinberg, David J Irwin, Keith A Josephs, Mario F Mendez, Patricio Chrem Mendez, Raffaella Migliaccio, Zachary A Miller, Maxime Montembeault, Melissa E Murray, Sára Nemes, Victoria Pelak, Daniela Perani, Jeffrey Phillips, Yolande Pijnenburg, Emily Rogalski, Jonathan M Schott, William Seeley, A Campbell Sullivan, Salvatore Spina, Jeremy Tanner, Jamie Walker, Jennifer L Whitwell, David A Wolk, Rik Ossenkoppele, Gil D Rabinovici
BACKGROUND: Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy in a large international cohort. METHODS: We searched PubMed between database inception and Aug 1, 2021, for all published research studies on posterior cortical atrophy and related terms...
February 2024: Lancet Neurology
#16
JOURNAL ARTICLE
Eric M Reiman, Jeffrey L Cummings, Jessica B Langbaum, Soeren Mattke, Robert C Alexander
No abstract text is available yet for this article.
February 2024: Lancet Neurology
#17
JOURNAL ARTICLE
Alexandre Bejanin, Nicolas Villain
No abstract text is available yet for this article.
February 2024: Lancet Neurology
#18
JOURNAL ARTICLE
Leiwen Fu, Tian Tian, Bingyi Wang, Zhen Lu, Junye Bian, Weijie Zhang, Xinsheng Wu, Xinyi Li, Richard C Siow, Evandro Fei Fang, Na He, Huachun Zou
BACKGROUND: Sexually active older adults are often more susceptible to HIV and other sexually transmitted infections (STIs) due to various health conditions (especially a weakened immune system) and low use of condoms. We aimed to assess the global, regional, and national burdens and trends of HIV and other STIs in older adults from 1990 to 2019. METHODS: We retrieved data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 on the incidence and disability-adjusted life-years (DALYs) of HIV and other STIs (syphilis, chlamydia, gonorrhoea, trichomoniasis, and genital herpes) for older adults aged 60-89 years in 204 countries and territories from 1990 to 2019...
January 2024: The Lancet. Healthy longevity
#19
JOURNAL ARTICLE
Rubén López-Bueno, Lin Yang, Emmanuel Stamatakis, Borja Del Pozo Cruz
BACKGROUND: Data for the dose-response associations of moderate physical activity (MPA) and vigorous physical activity (VPA) with Alzheimer's disease-related mortality are scarce. We aimed to examine the prospective associations of such activity with Alzheimer's disease-related mortality. METHODS: In this dose-response, population-based study, we pooled data from 22 consecutive waves of the US National Health Interview Survey (from 1997 to 2018). Participants aged 68 years or older were included in the study if they had full data for physical or muscle-strengthening activity, chronic conditions, functional limitations, marital status, education level, alcohol consumption, smoking status, and BMI, and follow-up time after study entry...
December 2023: The Lancet. Healthy longevity
#20
JOURNAL ARTICLE
Lucy A Cunningham, Filipa Landeiro, José Leal
BACKGROUND: Dementia and Alzheimer's disease are the leading cause of death in England, with prevalence estimated to rise with an ageing population. 2021 cost estimates were £25 billion, rising to an estimated £47 billion in 2050. Brain health clinics (BHC) offer patients with memory concerns access to higher quality memory assessment and imaging than memory clinics, which are the usual care. BHCs aim to offer patients a more accurate and timely diagnosis, resulting in more specific treatment options...
November 2023: Lancet
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