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Hobnail papillary thyroid

Luca Morandi, Alberto Righi, Francesca Maletta, Paola Rucci, Fabio Pagni, Marco Gallo, Sabrina Rossi, Leonardo Caporali, Anna Sapino, Ricardo V Lloyd, Sofia Asioli
Hobnail variant of papillary thyroid carcinoma (HPTC) represents a recently described, aggressive and rare group of thyroid tumors with poorly understood pathogenesis. Molecular data about this group of cancers are few, and a more detailed molecular characterization of these tumors is needed. The main objective of the study is to define a comprehensive molecular typing of HPTC. Eighteen patients affected by HPTC, including eighteen primary tumors and four lymph node metastases, were screened for NRAS, KRAS, HRAS, BRAF, TP53, PIK3CA, hTERT, PTEN, CDKN2A, EGFR, AKT1, CTNNB1 and NOTCH1 gene mutations...
February 2017: Endocrine-related Cancer
José M Cameselle-Teijeiro, Irene Rodríguez-Pérez, Ricardo Celestino, Catarina Eloy, Magalí Piso-Neira, Ihab Abdulkader-Nallib, Paula Soares, Manuel Sobrinho-Simões
The hobnail variant (HV) of papillary thyroid carcinoma (PTC) is an unusual entity recently proposed as an aggressive variant of PTC. We describe the pathologic and molecular features of 2 cases of HV of PTC. Both tumors presented in stage III (pT3 pN1a M0). The first case was diagnosed in a 62-year-old man, whereas the second was in a 53-year-old woman. Both patients were treated with total thyroidectomy and radioactive iodine. The primary tumors showed a hobnail/micropapillary pattern in ≥50% of the neoplasm, and positivity for TTF-1, TTF-2, thyroglobulin (TG), cyclin D1, and p53...
December 22, 2016: American Journal of Surgical Pathology
Antonio Ieni, Valeria Barresi, Roberta Cardia, Luana Licata, Flavia Di Bari, Salvatore Benvenga, Giovanni Tuccari
Papillary thyroid carcinoma (PTC) has a good prognosis with a 10-yr survival greater than 90%. Recently, a micro-papillary pattern with hobnail appearance (MPHC) in PTC has been indicated as associated with poor prognosis, but this suggestion is based only on a few cases from geographical areas different from ours. Two-hundred ninety-nine consecutive PTC cases were collected between the years of 1992 and 2014 at our institution. The corresponding histologic sections (at least 6 for each case) were stained with hematoxylin and eosin and reviewed independently by two pathologists to reach a consensus on the identification and quantification of the MPHC...
November 28, 2016: Reviews in Endocrine & Metabolic Disorders
Young Sub Lee, Yourha Kim, Sora Jeon, Ja Seong Bae, So Lyung Jung, Chan Kwon Jung
The hobnail variant of papillary thyroid carcinoma (PTC) is a rare, aggressive variant in which > 30% of the tumor cells have hobnail features. The clinical behavior and pathologic characteristics of these tumors are still unclear due to the rarity of the entity. The present study aimed to investigate cytologic, clinical, pathological, and molecular features of the hobnail variant from our data and from the literature. We retrospectively retrieved 10 cases of hobnail variant from 2,904 consecutive PTC patients...
2015: International Journal of Clinical and Experimental Pathology
Joerg Schwock, Gita Desai, Karen M Devon, Ozgur Mete, Valérie Dubé
No abstract text is available yet for this article.
December 2015: Diagnostic Cytopathology
Serpil Dizbay Sak
Classically characterized by its papillary appearance, papillary thyroid carcinoma is the most common malignant neoplasm of the thyroid. Several variants of papillary carcinoma have been described considering size (microcarcinoma); nature of the tumor boundaries (encapsulated); architecture (follicular, macrofollicular, cribriform-morular, solid, micropapillary); cellular characteristics (tall cell, columnar, oncocytic, clear cell, hobnail); additional tumor components (papillary carcinoma with focal insular component, papillary carcinoma with spindle and giant cell carcinoma, papillary carcinoma with squamous cell carcinoma, papillary carcinoma with mucoepidermoid carcinoma); stromal features (papillary carcinoma with fasciitis like stroma); or a combination of the abovementioned characteristics (diffuse sclerosing, Warthin-like)...
2015: Türk Patoloji Dergisi
Jianjun Xie, Yumin Wang, Jie Zhang, Renya Zhang
No abstract text is available yet for this article.
January 2015: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Changli Yue, Yong Zhang, Li Xing, Yihua Zhao, Jiamin Chen, Yulan Jin, Honggang Liu
OBJECTIVE: To explore the relationship between histomorphological factors and lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC). METHODS: A total of 153 paraffin-embedded specimens of PTC treated at Beijing Tongren Hospital, Capital Medical University were collected from January 1, 2006 to December 31, 2013 and assessed by hematoxylin and eosin staining. The tumor growth patterns (infiltrative tumor border, lateral tubular growth and intraglandular dissemination), histomorphological characteristics (hobnail features, loss of cohesiveness/polarity (LOCP) and micropapillary structures) and several clinicopathological parameters were evaluated for their values in LNM...
December 16, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Anne Marie Amacher, Bella Goyal, James S Lewis, Samir K El-Mofty, Rebecca D Chernock
Papillary thyroid carcinoma is the most common thyroid carcinoma and has a generally favorable prognosis. There are several well-characterized variants, some of which are associated with more aggressive clinical behavior. Hobnail is a recently described rare variant that appears to behave more aggressively. Initial reports characterizing this variant focused on primary tumors and excluded other recognized variants, as well as poorly differentiated and anaplastic thyroid carcinomas, from analysis. Here, we evaluate the frequency of hobnail features in both primary and metastatic papillary thyroid carcinomas, including in association with other known variants, and also in poorly differentiated and anaplastic thyroid carcinomas...
February 2015: American Journal of Surgical Pathology
Ayana Suzuki, Mitsuyoshi Hirokawa, Miyoko Higuchi, Naoki Yamao, Seiji Kuma, Hirotoshi Nakamura, Nobuyuki Amino, Akira Miyauchi
BACKGROUND: The cytological findings in conventional specimens (C-S) and liquid-based cytology specimens (LBC-S) are not quite same. The aim of this article is to clarify the cytological findings of papillary thyroid carcinoma (PTC) characteristic of LBC-S. METHODS: Out of 5,971 cases diagnosed in a single institution from March to September in 2012, 161 PTC cases with both C-S and LBC-S were reviewed. Additionally, we compared the findings with those in LBC-S of 55 adenomatous or hyperplastic nodule (AN) and 21 follicular neoplasm (FN) cases...
February 2015: Diagnostic Cytopathology
Carrie C Lubitz, Konstantinos P Economopoulos, Amanda C Pawlak, Kerry Lynch, Dora Dias-Santagata, William C Faquin, Peter M Sadow
BACKGROUND: Papillary thyroid carcinoma (PTC) is increasing in incidence while mortality is unchanged. Identifying patients with higher risk of recurrence and death is essential. Case series identify the hobnail variant of PTC (HVPTC), which is characterized by micropapillary architecture, apocrine features, and loss of cellular polarity. Herein, we describe the clinical course, pathologic features, and mutational profile of patients at our institution with HVPTC. METHODS: A query into the surgical pathologic database (2009-2012) was performed, and clinicopathologic data were collected on all patients carrying the diagnosis of HVPTC...
June 2014: Thyroid: Official Journal of the American Thyroid Association
Sofia Asioli, Francesca Maletta, Fabio Pagni, Donatella Pacchioni, Alice Vanzati, Sara Mariani, Nicola Palestini, Ricardo V Lloyd, Anna Sapino
Recent reports indicate that hobnail papillary thyroid carcinoma (HPTC) is a rare, but very aggressive variant of papillary thyroid carcinoma. The authors describe the cytological features of five HPTC on fine-needle aspiration biopsies (FNAB). Moreover, their immunophenotype and the presence of B-RAF mutation by pyrosequencing were investigated. The patients' (three females and two males) age ranged from 27 to 86 (mean 65) years. Tumor size ranged from 2 to 9 cm (mean 4.2 cm). FNAB were highly cellular with a bloody background and scant colloid...
January 2014: Diagnostic Cytopathology
N Takagi, M Hirokawa, Y Nobuoka, M Higuchi, S Kuma, A Miyauchi
BACKGROUND: A diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a rare variant and reports describing the cytological findings are few. PATIENTS AND METHODS: We studied 24 cytological samples from thyroid fine needle aspirates of 20 patients with DSV-PTC. The specimens were taken from 14 non-nodular lesions and 10 nodules. RESULTS: All aspirates taken from both non-nodular lesions and nodules had sufficient cellularity...
June 2014: Cytopathology: Official Journal of the British Society for Clinical Cytology
Soo Young Chung, Jae Seok Lee, Hyebin Lee, Sung Hee Park, Soo Jin Kim, Han Suk Ryu
OBJECTIVE: Preoperative fine needle aspiration biopsy (FNAB) has become the initial diagnostic method for papillary thyroid carcinoma (PTC). Identification of cytomorphologic factors predicting lymph node metastasis (LNM) is clinically important for determining the appropriate treatment regimen due to the high rate of lymph node involvement in PTC at the time of diagnosis. Hobnail features (HF) have previously been described as potential histomorphologic features in the histological examination of PTC...
2013: Acta Cytologica
Jae Seok Lee, Hee-Seung Choi, In Ae Park, Han Suk Ryu
OBJECTIVE: The morphological interpretation of liquid-based preparation (LBP) remains a diagnostic challenge due to altered cytomorphology with technical reason. Only a few published accounts of the cytopathological features needed for diagnosis of papillary thyroid carcinoma (PTC) on an LBP exist. We utilized the SurePath LBP system to evaluate conventional and newly recognized cytomorphologic features on histologically confirmed PTC to identify their potent diagnostic significance compared to benign follicular neoplasm (BFN)...
2013: Acta Cytologica
Yun J Chung, Jae S Lee, So Y Park, Hyo J Park, Bo Y Cho, Sung J Park, Sei Y Lee, Kyung-Ho Kang, Han S Ryu
AIMS: Few clinicopathological parameters have been identified as independent predictive factors for lymph node metastasis. This study evaluated the predictive ability of three histological characteristics of PTC in lymph node metastases: hobnail features, loss of cohesiveness/polarity (LOCP) and micropapillary structures. METHODS AND RESULTS: Tissue specimens from 153 patients with histologically confirmed PTC including 112 cases of papillary thyroid microcarcinoma (PTMC) were enrolled in this study...
March 2013: Histopathology
Grace C H Yang, Karen Fried, Theresa Scognamiglio
Primary thyroid tumors with extensive clear cell changes are extremely rare. More than 10,000 ultrasound-guided thyroid fine needle aspirations examined over a period of 17 years by the first author, only one of the 530 (<0.2%) papillary thyroid carcinomas (PTCs) and three of the 42 (7.1%) follicular thyroid carcinomas (FTCs) had extensive cytoplasmic clearing. Thyroidectomies were performed for these cases at four different hospitals in New York City. Final pathology was available for review in each of the four cases...
September 2013: Diagnostic Cytopathology
Claudio Bellevicine, Immacolata Cozzolino, Umberto Malapelle, Pio Zeppa, Giancarlo Troncone
BACKGROUND: Papillary thyroid carcinoma (PTC) with prominent hobnail features is a recently recognized PTC variant. Its histological hallmark is represented by elongated cells showing a high nuclear/cytoplasmic ratio and a hobnail appearance. Few histological studies have been performed showing aggressive clinical and pathological features. Thus, a better patient management might benefit from its early diagnosis on fine needle aspiration (FNA) samples. To date, the FNA cytology of PTC with prominent hobnail features has not been described...
2012: Acta Cytologica
Sofia Asioli, Lori A Erickson, Alberto Righi, Ricardo V Lloyd
Recent reports indicate that papillary thyroid carcinoma with hobnail features, also designated as micropapillary variant of papillary thyroid carcinoma, is a rare but very aggressive variant of papillary thyroid carcinoma. We examined the histopathologic and immunohistochemical features of 24 cases of papillary thyroid carcinoma with hobnail/micropapillary component to determine the prognostic significance of the amount of hobnail/micropapillary features in these tumors. The patients included 18 women and 6 men...
March 2013: Human Pathology
Leonardo Saúl Lino-Silva, Hugo R Domínguez-Malagón, Claudia Haydee Caro-Sánchez, Rosa Angélica Salcedo-Hernández
Micropapillary carcinoma is a histologic pattern, rather than an independent entity, that has an aggressive clinical behavior regardless of location. Histologically, it is characterized by papillary cell groups in clear spaces. The micropapillary pattern in the thyroid gland has not been studied until recently but under other names such as hobnail features or oncocytic and, therefore, is poorly understood, and reported cases are few. We report the clinicopathologic features of 7 cases obtained from a cohort of 496 papillary thyroid carcinomas, which corresponds to a prevalence of 1...
October 2012: Human Pathology
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