Read by QxMD icon Read


Zhi-Rui Yang, Li Yu, Hai-Yan Zhu
Cancer-testis antigens (CTA) are a class of tumor-associated antigens, which are mainly located in X chromosome. CTA restrictively expressed in normal testis, ovary, placenta and so on. Their expression in other normal tissues is much lower, even can not be detected. However, their expressions are aberrantly high in human cancers. Based on CTA encoding immunogenic proteins, they can be regulated by epigentics, CTA provides very attractive targets for cancer immunotherapy. Multiple myeloma (MM) is incurable and has a low cureative rate and a high relapse rate...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
Jun Li, Jiang Yu, Shaojian Xu, Jianli Shi, Shengnan Xu, Xiaoyan Wu, Fang Fu, Zhe Peng, Lingling Zhang, Shuxuan Zheng, Xiaoyuan Yuan, Xiaoyan Cong, Wenbo Sun, Kaihui Cheng, Yijun Du, Jiaqiang Wu, Jinbao Wang
BACKGROUND: This study aimed at reseaching the immune effect of porcine circovirus type 2 (PCV2) DNA vaccine containing CpG motif on mice. METHODS: A total of 40 6-week-old female BALB/c mice were randomly divided into four groups which were immunized by 18CpG-pVAX1-ORF2, pVAX1-ORF2, pVAX1 and PBS, respectively, and immunized again 2 weeks later. All mice were challenged with 0.2 mL PCV2 cells virulent strain SD (10(6.0) TCID50/mL) after 4 weeks. Average daily gain, blood antibody levels, microscopic changes and viremia were detected to estimate the effect of DNA vaccine...
November 14, 2016: Virology Journal
Julie E Weiss, Martha Goodrich, Kimberly A Harris, Rachael E Chicoine, Marie B Synnestvedt, Steve J Pyle, Jane S Chen, Sally D Herschorn, Elisabeth F Beaber, Jennifer S Haas, Anna N A Tosteson, Tracy Onega
PURPOSE: To assess indication for examination for four breast imaging modalities and describe the complexity and heterogeneity of data sources and ascertainment methods. METHODS: Indication was evaluated among the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) breast cancer research centers (PRCs). Indication data were reported overall and separately for four breast imaging modalities: digital mammography (DM), digital breast tomosynthesis (DBT), ultrasound (US), and magnetic resonance imaging (MRI)...
February 2017: Journal of the American College of Radiology: JACR
Min Wang, Li-Ru Wang
Ki-67 antigen expression is closely associated with the cell cycle. Its expression is in almost the entire mitosis in cell cycle. Detection of Ki-67 antigen can reflect the cell proliferation activity in hematological malignancies. Detection of Ki-67 has been widely applied in staging, therapy effect monitoring and prognosis judgment in lymphoma. There has been a lot of studies investigating the expression of Ki-67 in acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL), and investigating the relevance between Ki-67 expression and therapy effect and prognosis...
August 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Ke-qiang Yu, Yan-ru Zhao, Fei Liu, Ji-yu Peng, Yong He
Laser-induced breakdown spectroscopy (LIBS), as a kind of atomic emission spectroscopy, has been considered to be a future new tool for chemical analysis due to its unique features, such as no need of sample preparation, stand-off or remote analysis. What's more it can achieve fast and multi-element analysis. Therefore, LIBS technology is regarded as a future "SurperStar" in the field of chemical analysis and green analytical techniques. At present, rapid and accurate detection and prevention of soil contamination (mainly in pollutants of heavy metals and organic matter) is deemed to be a concerned and serious central issue in modern agriculture and agricultural sustainable development...
March 2016: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
Karine Briot, Jacques Fechtenbaum, Christian Roux
No abstract text is available yet for this article.
August 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Aiji Yajima, Ken Tsuchiya, Hiroki Yokota, Kosaku Nitta
The pathophysiology and treatment for renal bone disease have made remakable progress. Moreover, osteocyte reseach has made tremendous progress. In the clinical aspect, (1) hyperphosphatemia, (2) hyperparathyroid and hypoparathyroid bone disease in patients with chronic kidney disease, (3) increased serum level of fibroblast growth factor 23 (FGF-23) and(4) reduced level of Klotho should be taken into consideration when analyzing these conditions. On the other hand, hyperphosphatemia must be successfully treated...
June 2016: Clinical Calcium
Chang-lei Wang, Shuai Wu, Yan-feng Li, Bo-wen Liu, Ming-lie Hu, Lu Chai, Qi-rong Xing, Qing-yue Wang
Vanadium dioxide (VO₂) film will be phase-transitioned from insulator into metal, accompanied with dramatic change on conductivity, which is named as photo-induced insulator-metal phase transition. Such phase transition of VO₂ film has important application potentials in modulators or other functional devices for terahertz waves. In this paper, the transmission spectrum variations before and after the photo-induced insulator-metal phase transition of vanadium dioxide film are investigated, and the phase transition properties in terahertz(THz) region are analyzed...
November 2015: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
Xin Zhao, Xiaogeng Wan, Rong L He, Stephen S-T Yau
The free-living SAR11 clade is a globally abundant group of oceanic Alphaproteobacteria, with small genome sizes and rich genomic A+T content. However, the taxonomy of SAR11 has become controversial recently. Some researchers argue that the position of SAR11 is a sister group to Rickettsiales. Other researchers advocate that SAR11 is located within free-living lineages of Alphaproteobacteria. Here, we use the natural vector representation method to identify the evolutionary origin of the SAR11 clade. This alignment-free method does not depend on any model assumptions...
May 2016: Molecular Phylogenetics and Evolution
Wentao Yang, Shaohua Shi, Guilian Yang, Chunfeng Wang
The influenza A virus (IAV) belongs to the family Influenza Virus and subfamily Orthomyxoviridae. The IAV can cause acute infections of the lower respiratory in human and animals. Recently, many studies have been performed to reveal the lung CD4+ T cells, CD8+ T cells and Tregs via multiple effector and regulatory mechanisms to against IAV. In this paper, we review the state of progress with regards to various strategies of IAV escape from T cell responses, T cells and innate T cells immunity against influenza virus, which will provide a useful reference tool for future related reseach...
July 2015: Bing du Xue Bao, Chinese Journal of Virology
Hongxia Su, Lei Liu, Yulin Zhao
Human myiasis is caused by the parasitic maggots of flies. We report a case of nasal myiasis in a 37-year-old woman in Henan. The patient presented with nasal foreign-body sensation, nansal itching sneezing, snuffle and such allergic symptoms in nasal cavity. Based on maggots that were bowed from the right nasal cavity, a detailed endoscopic examination, sinus CT scan and identification of the maggot's species done by parapsychologists of the parasitology teaching and reseach section of the Zhengzhou University School of Medicine, the diagnosis of human nasal infestation by oestrus ovis was definited...
June 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Yan Xu, Longyun Li, Mengzhao Wang
Leptomeningeal metastasis (LM) is one of the disastrous events in managing advanced non-small cell lung cancer (NSCLC) due to severe clinical symptoms and a grave prognosis. Although intrathecal (IT) chemotherapy show some effects for LM in advanced NSCLC, the prognosis is still poor (12 wk-14 wk). A large majority (84%-97%) of the patients were found to have adenocarcinoma histology. Epidermal growth factor receptor (EGFR) senstive mutations were detected in 43.0%-70.5% adenocarcinoma patients with LM. EGFR tyrosine kinase inhibitors (TKIs) showed to be effective for LM in selected NSCLC patients in some reseaches, and confer a survival benefit...
October 20, 2015: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Elizabeth Peter
A sound knowledge of the nature of qualitative research, along with an appreciation of some special ethical considerations, is needed for rigorous reviews to be conducted. The overall character of qualitative research is described with an emphasis on the tendency of qualitative researchers to explore sensitive topics using theoretically informed methods. A number of specific features of qualitative that require additional ethical attention and awareness are also examined including the following: 1) participants are frequently quite vulnerable and require protection because the data collection methods, such as in-depth interviews, can delve into personally and politically charged matters; 2) naturalistic observation can raise concerns regarding privacy and consent; 3) the potential for the identifiability of the results of this research may require extra efforts to maintain confidentiality...
September 2015: Ciência & Saúde Coletiva
Péter Halász
System epilepsy is an emerging concept interpreting major nonlesional epilepsies as epileptic dysfunctions of physiological systems. I extend here the concept of reflex epilepsy to epilepsies linked to input dependent physiological systems. Experimental and clinical reseach data were collected to create a coherent explanation of underlying pathomechanism in AE and NFLE. We propose that AE should be interpreted as epilepsy linked to the corticothalamic burst-firing mode of NREM sleep, released by evoked vigilance level oscillations characterized by reactive slow wave response...
2015: Behavioural Neurology
Farnaz Zahedi Avval, Shadi Shomali, Mohammad Nadri, Reza Boostani, Lida Jarahi, Masoud Youssefi
ST2 is a member of IL-1 receptor family expressed on Th2 cells and regulates Th2 responces. The gene of ST2 encodes soluble ST2 (sST2) and the transmembrane ST2 (ST2L) isoforms through alternative mRNA splicing. The discovery of IL33/ ST2 signaling pathway, has drawn a great scientific attention to this system. sST2 has been shown to be an indacating factor in various infl ammatory conditions. This study aims to evaluate serum sST2 levels in HTLV-1 infected patients. This study included 49 HTLV-1 seropositive cases of which 14 were sympthomatic...
June 2015: Acta Microbiologica et Immunologica Hungarica
Jinfeng Wang, Yuping Xie, Wei Ma
Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by repeated episodes of upper airway obstruction that results in brief periods of breathing cessation (apnea) or a marked reduction in airflow (hypopnea) during sleep. Asthma is a chronic inflammatory disease of the airways characterized by revesible air-flow obstruction and bronchial hyperresponsiveness. This article reviewed related reseaches progress of relationship between the obstructive sleep apnea hypopnea syndrom and asthma in the vascular endothelial growth factor, systemic inflammation, leptin, obesity, gastroesophageal reflux disease and upper airway diseases, excessive daytime sleepiness and asthma control...
February 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
V G Kondrashova, N S Dombrovskaya
The study involved 162 children with small anomalies of heart development (SAHD) in core group (children born to parents evacuated from the 30-km zone in childhood) and 39 children in the control group. Quality of life of adolescents was assessed by questionnaire MOS-SF-36 in the Russified version (changed by International reseach centre of life quality, Russia, St. Petersburg, 1998). In children of main group with SAHD, was established systemic pathological process involving not only the cardiovascular system, but also an autonomic nervous systems, hemostasis, upper gastro-intestinal tract, hepatobiliary, urinary system, musculoskeletal system and others, which causes polymorphic clinical picture...
January 2015: Likars'ka Sprava
Konstantinos Papoutsis, Christian Ukena, Martin Gottwik, Michael Böhm
AIMS: The present study investigates whether scientific abstracts, which were accepted for presentation at the annual meeting of the German Cardiac Society (DGK) will be published more frequently and with higher ranking than rejected abstracts. Additionally, we analyzed whether the current peer review process of the congress abstracts is able to identify research of high quality. METHODS: All abstracts submitted for the DGK meetings between 2006 and 2010 were anonymized and graded by 5-9 reviewers...
March 2015: Deutsche Medizinische Wochenschrift
Ralf Pröve
This article develops a comprehensive critique of historical research focussing on the mutual relations between social power and violence. According to the methodological initial hypothesis, due to the inadequate distinction between indigenious concept (from sources) and heuristic (from reseach) in the historical sciences, there have been very few valuable insights into these relations to date. In order to expand the research focus which is the objective of this article, the analysis draws on the two actor-centric reference systems of "certainty" and "order"...
2014: Revue de Synthèse
Mohammadkarim Bahadori, Khalil Momeni, Ramin Ravangard, Maryam Yaghoubi, Khalil Alimohammazdeh, Ehsan Teymourzadeh, Ali Mehrabi Tavana
BACKGROUND & AIM: Medical research institute is the main basis for knowledge production through conducting research, and paying attention to the research is one of the most important things in the scientific communities. At present, there is a large gap between knowledge production in Iran compared to that in other countries. This study aimed to identify the challenge of research system in a research institute of medical sciences in Iran. MATERIALS & METHODS: This was a descriptive and qualitative study conducted in the first 6 months of 2013...
2015: Global Journal of Health Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"