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https://www.readbyqxmd.com/read/28737680/mapping-quantitative-trait-loci-qtl-for-resistance-to-late-blight-in-tomato
#1
Dilip R Panthee, Ann Piotrowski, Ragy Ibrahem
Late blight caused by Phytophthora infestans (Montagne, Bary) is a devastating disease of tomato worldwide. There are three known major genes, Ph-1, Ph-2, and Ph-3, conferring resistance to late blight. In addition to these three genes, it is also believed that there are additional factors or quantitative trait loci (QTL) conferring resistance to late blight. Precise molecular mapping of all those major genes and potential QTL is important in the development of suitable molecular markers and hence, marker-assisted selection (MAS)...
July 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28733296/a-unified-multi-level-model-approach-to-assessing-patient-responsiveness-including-return-to-normal-minimally-important-differences-and-minimal-clinically-important-improvement-for-patient-reported-outcome-measures
#2
Adrian Sayers, Vikki Wylde, Erik Lenguerrand, Rachael Gooberman-Hill, Jill Dawson, David Beard, Andrew Price, Ashley W Blom
OBJECTIVE: This article reviews and compares four commonly used approaches to assess patient responsiveness with a treatment or therapy (return to normal (RTN), minimal important difference (MID), minimal clinically important improvement (MCII), OMERACT-OARSI [Outcome Measures in Rheumatology-Osteoarthris Reseach Society International] (OO)) and demonstrates how each of the methods can be formulated in a multilevel modelling (MLM) framework. DESIGN: Cohort study...
July 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28730062/challenges-faced-by-women-with-disabilities-in-accessing-sexual-and-reproductive-health-in-zimbabwe-the-case-of-chitungwiza-town
#3
Tafadzwa Rugoho, France Maphosa
BACKGROUND: Women with disabilities in Zimbabwe face numerous challenges in accessing sexual and reproductive health. Cultural belief still regards them as not sexually active. The government has also failed to promote policies that facilitate access to sexual and reproductive services by women with disabilities. OBJECTIVES: The reseach objectives were to explore the challenges faced by women with disabilities in accessing sexual and reproductive health in Zimbabwe...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28646406/podocytes-and-the-quest-for-precision-medicines-for-kidney-diseases
#4
REVIEW
Peter Mundel
In this review, I describe a 30-year journey in the quest for precision medicines for patients with kidney diseases. In 1987, when I started my reseach career, most scientists studying glomerular disease biology were focused on mesangial cells. The crucial role of the podocyte in many kidney diseases characterized by proteinuria, including focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy, had not yet been recognized. We were not aware of genetic causes or drivers of kidney diseases nor of molecular markers and cell culture systems for mechanistic studies of podocyte biology...
August 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28497234/the-2017-caldar-summer-institute-and-international-conference-promoting-global-health-precision-research-in-substance-abuse-hiv-and-care
#5
Yih-Ing Hser, Ming D Li, Christine Grella, Lynn Brecht, Zhiwei Chen, Sulie L Chang, Linda Chang, Jacques Normand, Betty Tai
The 2017 CALDAR Summer Institute on Longituidnal Research and International Conference Series to Promote Global Health will take place in Los Angeles Universal City, CA, USA from August 15 to August 17, 2017. The conference will present a selection of the lastest and most current reseach in the areas of addiction, HIV, and related treatment.
May 11, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28245420/-reseach-advances-on-cancer-testis-antigens-in-multiple-myeloma-review
#6
Zhi-Rui Yang, Li Yu, Hai-Yan Zhu
Cancer-testis antigens (CTA) are a class of tumor-associated antigens, which are mainly located in X chromosome. CTA restrictively expressed in normal testis, ovary, placenta and so on. Their expression in other normal tissues is much lower, even can not be detected. However, their expressions are aberrantly high in human cancers. Based on CTA encoding immunogenic proteins, they can be regulated by epigentics, CTA provides very attractive targets for cancer immunotherapy. Multiple myeloma (MM) is incurable and has a low cureative rate and a high relapse rate...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27842600/immunogenicity-of-porcine-circovirus-type-2-nucleic-acid-vaccine-containing-cpg-motif-for-mice
#7
Jun Li, Jiang Yu, Shaojian Xu, Jianli Shi, Shengnan Xu, Xiaoyan Wu, Fang Fu, Zhe Peng, Lingling Zhang, Shuxuan Zheng, Xiaoyuan Yuan, Xiaoyan Cong, Wenbo Sun, Kaihui Cheng, Yijun Du, Jiaqiang Wu, Jinbao Wang
BACKGROUND: This study aimed at reseaching the immune effect of porcine circovirus type 2 (PCV2) DNA vaccine containing CpG motif on mice. METHODS: A total of 40 6-week-old female BALB/c mice were randomly divided into four groups which were immunized by 18CpG-pVAX1-ORF2, pVAX1-ORF2, pVAX1 and PBS, respectively, and immunized again 2 weeks later. All mice were challenged with 0.2 mL PCV2 cells virulent strain SD (10(6.0) TCID50/mL) after 4 weeks. Average daily gain, blood antibody levels, microscopic changes and viremia were detected to estimate the effect of DNA vaccine...
November 14, 2016: Virology Journal
https://www.readbyqxmd.com/read/27744009/challenges-with-identifying-indication-for-examination-in-breast-imaging-as-a-key-clinical-attribute-in-practice-research-and-policy
#8
Julie E Weiss, Martha Goodrich, Kimberly A Harris, Rachael E Chicoine, Marie B Synnestvedt, Steve J Pyle, Jane S Chen, Sally D Herschorn, Elisabeth F Beaber, Jennifer S Haas, Anna N A Tosteson, Tracy Onega
PURPOSE: To assess indication for examination for four breast imaging modalities and describe the complexity and heterogeneity of data sources and ascertainment methods. METHODS: Indication was evaluated among the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) breast cancer research centers (PRCs). Indication data were reported overall and separately for four breast imaging modalities: digital mammography (DM), digital breast tomosynthesis (DBT), ultrasound (US), and magnetic resonance imaging (MRI)...
February 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27531813/-reseach-progress-of-ki-67-in-acute-myeloid-leukemia-review
#9
REVIEW
Min Wang, Li-Ru Wang
Ki-67 antigen expression is closely associated with the cell cycle. Its expression is in almost the entire mitosis in cell cycle. Detection of Ki-67 antigen can reflect the cell proliferation activity in hematological malignancies. Detection of Ki-67 has been widely applied in staging, therapy effect monitoring and prognosis judgment in lymphoma. There has been a lot of studies investigating the expression of Ki-67 in acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL), and investigating the relevance between Ki-67 expression and therapy effect and prognosis...
August 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27400532/-study-on-soil-elements-detection-with-laser-induced-breakdown-spectroscopy-a-review
#10
Ke-qiang Yu, Yan-ru Zhao, Fei Liu, Ji-yu Peng, Yong He
Laser-induced breakdown spectroscopy (LIBS), as a kind of atomic emission spectroscopy, has been considered to be a future new tool for chemical analysis due to its unique features, such as no need of sample preparation, stand-off or remote analysis. What's more it can achieve fast and multi-element analysis. Therefore, LIBS technology is regarded as a future "SurperStar" in the field of chemical analysis and green analytical techniques. At present, rapid and accurate detection and prevention of soil contamination (mainly in pollutants of heavy metals and organic matter) is deemed to be a concerned and serious central issue in modern agriculture and agricultural sustainable development...
March 2016: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/27381556/clinical-relevance-of-vertebral-fractures-in-men
#11
Karine Briot, Jacques Fechtenbaum, Christian Roux
No abstract text is available yet for this article.
August 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27230843/-bone-disease-in-the-field-of-ckd-mbd
#12
Aiji Yajima, Ken Tsuchiya, Hiroki Yokota, Kosaku Nitta
The pathophysiology and treatment for renal bone disease have made remakable progress. Moreover, osteocyte reseach has made tremendous progress. In the clinical aspect, (1) hyperphosphatemia, (2) hyperparathyroid and hypoparathyroid bone disease in patients with chronic kidney disease, (3) increased serum level of fibroblast growth factor 23 (FGF-23) and(4) reduced level of Klotho should be taken into consideration when analyzing these conditions. On the other hand, hyperphosphatemia must be successfully treated...
June 2016: Clinical Calcium
https://www.readbyqxmd.com/read/26978905/-reseach-on-thz-time-domain-spectrum-of-photo-induced-insulator-metal-phase-transition-of-vo%C3%A2-films
#13
Chang-lei Wang, Shuai Wu, Yan-feng Li, Bo-wen Liu, Ming-lie Hu, Lu Chai, Qi-rong Xing, Qing-yue Wang
Vanadium dioxide (VO₂) film will be phase-transitioned from insulator into metal, accompanied with dramatic change on conductivity, which is named as photo-induced insulator-metal phase transition. Such phase transition of VO₂ film has important application potentials in modulators or other functional devices for terahertz waves. In this paper, the transmission spectrum variations before and after the photo-induced insulator-metal phase transition of vanadium dioxide film are investigated, and the phase transition properties in terahertz(THz) region are analyzed...
November 2015: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/26926946/a-new-method-for-studying-the-evolutionary-origin-of-the-sar11-clade-marine-bacteria
#14
Xin Zhao, Xiaogeng Wan, Rong L He, Stephen S-T Yau
The free-living SAR11 clade is a globally abundant group of oceanic Alphaproteobacteria, with small genome sizes and rich genomic A+T content. However, the taxonomy of SAR11 has become controversial recently. Some researchers argue that the position of SAR11 is a sister group to Rickettsiales. Other researchers advocate that SAR11 is located within free-living lineages of Alphaproteobacteria. Here, we use the natural vector representation method to identify the evolutionary origin of the SAR11 clade. This alignment-free method does not depend on any model assumptions...
May 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/26524918/-research-progress-of-study-on-function-of-t-cell-immunity-against-influenza-virus
#15
REVIEW
Wentao Yang, Shaohua Shi, Guilian Yang, Chunfeng Wang
The influenza A virus (IAV) belongs to the family Influenza Virus and subfamily Orthomyxoviridae. The IAV can cause acute infections of the lower respiratory in human and animals. Recently, many studies have been performed to reveal the lung CD4+ T cells, CD8+ T cells and Tregs via multiple effector and regulatory mechanisms to against IAV. In this paper, we review the state of progress with regards to various strategies of IAV escape from T cell responses, T cells and innate T cells immunity against influenza virus, which will provide a useful reference tool for future related reseach...
July 2015: Bing du Xue Bao, Chinese Journal of Virology
https://www.readbyqxmd.com/read/26514015/-one-case-of-human-nasal-myiasis
#16
Hongxia Su, Lei Liu, Yulin Zhao
Human myiasis is caused by the parasitic maggots of flies. We report a case of nasal myiasis in a 37-year-old woman in Henan. The patient presented with nasal foreign-body sensation, nansal itching sneezing, snuffle and such allergic symptoms in nasal cavity. Based on maggots that were bowed from the right nasal cavity, a detailed endoscopic examination, sinus CT scan and identification of the maggot's species done by parapsychologists of the parasitology teaching and reseach section of the Zhengzhou University School of Medicine, the diagnosis of human nasal infestation by oestrus ovis was definited...
June 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26483335/-diagnosis-and-treatment-of-leptomeningeal-metastasis-in-non-small-cell-lung-cancer
#17
REVIEW
Yan Xu, Longyun Li, Mengzhao Wang
Leptomeningeal metastasis (LM) is one of the disastrous events in managing advanced non-small cell lung cancer (NSCLC) due to severe clinical symptoms and a grave prognosis. Although intrathecal (IT) chemotherapy show some effects for LM in advanced NSCLC, the prognosis is still poor (12 wk-14 wk). A large majority (84%-97%) of the patients were found to have adenocarcinoma histology. Epidermal growth factor receptor (EGFR) senstive mutations were detected in 43.0%-70.5% adenocarcinoma patients with LM. EGFR tyrosine kinase inhibitors (TKIs) showed to be effective for LM in selected NSCLC patients in some reseaches, and confer a survival benefit...
October 20, 2015: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/26331494/the-ethics-in-qualitative-health-research-special-considerations
#18
Elizabeth Peter
A sound knowledge of the nature of qualitative research, along with an appreciation of some special ethical considerations, is needed for rigorous reviews to be conducted. The overall character of qualitative research is described with an emphasis on the tendency of qualitative researchers to explore sensitive topics using theoretically informed methods. A number of specific features of qualitative that require additional ethical attention and awareness are also examined including the following: 1) participants are frequently quite vulnerable and require protection because the data collection methods, such as in-depth interviews, can delve into personally and politically charged matters; 2) naturalistic observation can raise concerns regarding privacy and consent; 3) the potential for the identifiability of the results of this research may require extra efforts to maintain confidentiality...
September 2015: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/26175547/are-absence-epilepsy-and-nocturnal-frontal-lobe-epilepsy-system-epilepsies-of-the-sleep-wake-system
#19
REVIEW
Péter Halász
System epilepsy is an emerging concept interpreting major nonlesional epilepsies as epileptic dysfunctions of physiological systems. I extend here the concept of reflex epilepsy to epilepsies linked to input dependent physiological systems. Experimental and clinical reseach data were collected to create a coherent explanation of underlying pathomechanism in AE and NFLE. We propose that AE should be interpreted as epilepsy linked to the corticothalamic burst-firing mode of NREM sleep, released by evoked vigilance level oscillations characterized by reactive slow wave response...
2015: Behavioural Neurology
https://www.readbyqxmd.com/read/26132834/status-of-soluble-st2-levels-in-serum-of-htlv-1-infected-individuals
#20
Farnaz Zahedi Avval, Shadi Shomali, Mohammad Nadri, Reza Boostani, Lida Jarahi, Masoud Youssefi
ST2 is a member of IL-1 receptor family expressed on Th2 cells and regulates Th2 responces. The gene of ST2 encodes soluble ST2 (sST2) and the transmembrane ST2 (ST2L) isoforms through alternative mRNA splicing. The discovery of IL33/ ST2 signaling pathway, has drawn a great scientific attention to this system. sST2 has been shown to be an indacating factor in various infl ammatory conditions. This study aims to evaluate serum sST2 levels in HTLV-1 infected patients. This study included 49 HTLV-1 seropositive cases of which 14 were sympthomatic...
June 2015: Acta Microbiologica et Immunologica Hungarica
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