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https://www.readbyqxmd.com/read/28098776/distinguishing-benign-from-malignant-pancreatic-and-periampullary-lesions-using-combined-use-of-%C3%A2-h-nmr-spectroscopy-and-gas-chromatography-mass-spectrometry
#1
Yarrow J McConnell, Farshad Farshidfar, Aalim M Weljie, Karen A Kopciuk, Elijah Dixon, Chad G Ball, Francis R Sutherland, Hans J Vogel, Oliver F Bathe
Previous work demonstrated that serum metabolomics can distinguish pancreatic cancer from benign disease. However, in the clinic, non-pancreatic periampullary cancers are difficult to distinguish from pancreatic cancer. Therefore, to test the clinical utility of this technology, we determined whether any pancreatic and periampullary adenocarcinoma could be distinguished from benign masses and biliary strictures. Sera from 157 patients with malignant and benign pancreatic and periampullary lesions were analyzed using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS)...
January 13, 2017: Metabolites
https://www.readbyqxmd.com/read/28098165/combination-of-mometasone-furoate-and-oxymetazoline-for-the-treatment-of-adenoid-hypertrophy-concomitant-with-allergic-rhinitis-a-randomized-controlled-trial
#2
Wenlong Liu, Lifeng Zhou, Qingxiang Zeng, Renzhong Luo
In the clinic, approximately 30% of children with adenoid hypertrophy (AH) concomitant with allergic rhinitis (AR) report poor responses to intranasal steroids. To determine whether the combination of mometasone furoate (MF) and oxymetazoline (OXY) is more effective than either agent alone, we performed a two-stage, parallel, randomized, double-blind, double-dummy, clinical trial with 240 AH children with concomitant perennial AR. During the first stage, all children were randomly assigned to the MF or control group for six weeks of treatment...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28098056/follow-up-of-multicentric-hcc-according-to-the-mrecist-criteria-role-of-320-row-ct-with-semi-automatic-3d-analysis-software-for-evaluating-the-response-to-systemic-therapy
#3
M Telegrafo, G Dilorenzo, G Di Giovanni, I Cornacchia, A A Stabile Ianora, I Cornacchia, A A Stabile Ianora, G Angelelli, M Moschetta
AIM: To evaluate the role of 320-detector row computed tomography (MDCT) with 3D analysis software in follow up of patients affected by multicentric hepatocellular carcinoma (HCC) treated with systemic therapy by using modified response evaluation criteria in solid tumors (mRECIST). PATIENTS AND METHODS: 38 patients affected by multicentric HCC underwent MDCT. All exams were performed before and after iodinate contrast material intravenous injection by using a 320-detection row CT device...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28097902/mistreatment-of-medical-students-in-the-third-year-may-not-be-the-problem
#4
Stuart J Slavin, John T Chibnall
Mistreatment and abuse of medical students has been recognized as a significant problem in medical schools. We believe, however, that the problem of mistreatment has been viewed incorrectly. This misperception of mistreatment exists in two primary ways. First, mistreatment has tended to be viewed as a "diagnosis" of unprofessionalism of the perpetrator when it may be more appropriately viewed as a symptom with a range of possible underlying causes. The second misconception that appears to be prevalent is the belief that the link between mistreatment and student well-being, distress, and falling empathy is clear...
January 18, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28096304/antibiotic-cycling-and-antibiotic-mixing-which-one-best-mitigates-antibiotic-resistance
#5
R E Beardmore, R Pena-Miller, F Gori, J Iredell
Can we exploit our burgeoning understanding of molecular evolution to slow the progress of drug resistance? One role of an infection clinician is exactly that: to foresee trajectories to resistance during antibiotic treatment and to hinder that evolutionary course. But can this be done at a hospital-wide scale? Clinicians and theoreticians tried to when they proposed two conicting behavioural strategies that are expected to curb resistance evolution in the clinic, these are known as 'antibiotic cycling' and 'antibiotic mixing'...
January 17, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28095438/vh1-family-immunoglobulin-repertoire-sequencing-after-allogeneic-hematopoietic-stem-cell-transplantation
#6
Maya K Sethi, Felicitas Thol, Michael Stadler, Michael Heuser, Arnold Ganser, Christian Koenecke, Oliver Pabst
After allogeneic hematopoietic stem cell transplantation (HSCT), recovery of humoral immunity is essential to protect from life-threatening infections. However, monitoring the humoral immune system after transplantation with standard techniques in the clinical routine is imprecise. Here, we performed sequencing of mononuclear bone marrow cells to characterize the VH1-repertoire of switched B cells of healthy volunteers and patients undergoing HSCT. Analysis of healthy bone marrow donors and patients showed virtually no clonally related sequences between individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28094850/discriminating-solitary-cysts-from-soft-tissue-lesions-in-mammography-using-a-pretrained-deep-convolutional-neural-network
#7
Thijs Kooi, Bram van Ginneken, Nico Karssemeijer, Ard den Heeten
PURPOSE: It is estimated that 7% of women in the western world will develop palpable breast cysts in their lifetime. Even though cysts have been correlated with risk of developing breast cancer, many of them are benign and do not require follow-up. We develop a method to discriminate benign solitary cysts from malignant masses in digital mammography. We think a system like this can have merit in the clinic as a decision aid or complementary to specialised modalities. METHODS: We employ a deep Convolutional Neural Network (CNN) to classify cyst and mass patches...
January 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28094589/leucine-rich-%C3%AE-2-glycoprotein-as-the-acute-phase-reactant-to-detect-systemic-juvenile-idiopathic-arthritis-disease-activity-during-anti-interleukin-6-blockade-therapy-a-case-series
#8
Masaki Shimizu, Yasuo Nakagishi, Natsumi Inoue, Mao Mizuta, Akihiro Yachie
OBJECTIVES: To assess the role of leucine-rich α2-glycoprotein (LRG) as a biomarker for monitoring systemic juvenile idiopathic arthritis (s-JIA) disease activity during interleukin (IL)-6 blockade treatment. METHODS: We serially measured serum LRG levels in four s-JIA patients treated with the anti-IL-6 receptor antibody tocilizumab and determined the correlation between clinical symptoms and other inflammatory biomarkers and proinflammatory cytokines, including IL-18, IL-6, neopterin, and tumor necrosis factor-α receptor type I and II...
January 17, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28094167/seizures-and-antiseizure-medications-are-important-to-parents-of-newborns-with-seizures
#9
Elizabeth Hill, Hannah Cranley Glass, Kelli Kelley, Marty Barnes, Stephanie Rau, Linda S Franck, Renée A Shellhaas
BACKGROUND: Neonatal seizures and antiseizure medications both have potentially serious consequences on the developing brain. As such, optimal treatment of neonatal seizures remains unclear. Moreover, little is known about parental experiences, concerns, or unanswered questions. We conducted an online survey to assess parental perspectives regarding neonatal seizures and their management, along with their suggestions for specific high priority research topics. METHODS: Parents whose children had neonatal seizures were recruited through social media support groups to complete an online survey...
October 8, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/28093637/exploring-differences-in-adverse-symptom-event-grading-thresholds-between-clinicians-and-patients-in-the-clinical-trial-setting
#10
Thomas M Atkinson, Lauren J Rogak, Narre Heon, Sean J Ryan, Mary Shaw, Liora P Stark, Antonia V Bennett, Ethan Basch, Yuelin Li
PURPOSE: Symptomatic adverse event (AE) monitoring is essential in cancer clinical trials to assess patient safety, as well as inform decisions related to treatment and continued trial participation. As prior research has demonstrated that conventional concordance metrics (e.g., intraclass correlation) may not capture nuanced aspects of the association between clinician and patient-graded AEs, we aimed to characterize differences in AE grading thresholds between doctors (MDs), registered nurses (RNs), and patients using the Bayesian Graded Item Response Model (GRM)...
January 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28093576/synthetic-%C3%AE-hydroxytropolones-as-inhibitors-of-hiv-reverse-transcriptase-ribonuclease-h-activity
#11
Ryan P Murelli, Michael P D'Erasmo, Danielle R Hirsch, Christine Meck, Takashi Masaoka, Jennifer A Wilson, Baofeng Zhang, Rajat K Pal, Emilio Gallicchio, John A Beutler, Stuart F J Le Grice
HIV Reverse Transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development that has not been successfully targeted in the clinic. While the α-hydroxytropolone-containing natural products β-thujaplicinol and manicol have emerged as some of the most potent leads described to date, structure-function studies have been limited to the natural products and semi-synthetic derivatives of manicol. Thus, a library of α-hydroxytropolones synthesized through a convenient oxidopyrylium cycloaddition/ring-opening sequence have been tested in in vitro and cell-based assays, and have been analyzed using computational support...
September 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/28093049/efficient-variational-approach-to-multimodal-registration-of%C3%A2-anatomical%C3%A2-and%C3%A2-functional-intra-patient-tumorous-brain-data
#12
Alvar-Ginés Legaz-Aparicio, Rafael Verdú-Monedero, Jorge Larrey-Ruiz, Juan Morales-Sánchez, Fernando López-Mir, Valery Naranjo, Ángela Bernabéu
This paper addresses the functional localization of intra-patient images of the brain. Functional images of the brain (fMRI and PET) provide information about brain function and metabolism whereas anatomical images (MRI and CT) supply the localization of structures with high spatial resolution. The goal is to find the geometric correspondence between functional and anatomical images in order to complement and fuse the information provided by each imaging modality. The proposed approach is based on a variational formulation of the image registration problem in the frequency domain...
November 29, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28092318/opening-injection-pressure-is-higher-in-intraneural-compared-with-perineural-injections-during-simulated-nerve-blocks-of-the-lower-limb-in-fresh-human-cadavers
#13
Kris Vermeylen, Marlies Hermans, Filiep Soetens, Evie Vereecke, Thorsten Steinfeldt, Gerbrand Groen, Admir Hadzic, Marc Van de Velde
BACKGROUND AND OBJECTIVES: Needle-induced nerve trauma and intraneural injection can lead to neurologic injury during peripheral nerve blocks. In this study, we assessed the utility of opening injection pressure (OIP), time to OIP, and rate of rise to OIP in detecting needle-nerve contact and intraneural injection. METHODS: Five common ultrasound-guided blocks of the femoral, saphenous, subgluteal sciatic, tibial, and common peroneal nerves were simulated in 10 fresh cadavers...
January 13, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28092290/clinical-recommendations-of-cardiac-magnetic-resonance-part-ii-inflammatory-and-congenital-heart-disease-cardiomyopathies-and-cardiac-tumors-a-position-paper-of-the-working-group-applicazioni-della-risonanza-magnetica-of-the-italian-society-of-cardiology
#14
Gianluca Pontone, Gianluca Di Bella, Castelletti Silvia, Viviana Maestrini, Pierluigi Festa, Lamia Ait-Ali, Pier Giorgio Masci, Lorenzo Monti, Gabriella di Giovine, Manuel De Lazzari, Alberto Cipriani, Andrea I Guaricci, Santo Dellegrottaglie, Alessia Pepe, Martina Perazzolo Marra, Giovanni Donato Aquaro
The current document was developed by the working group on the 'application of cardiac magnetic resonance' of the Italian Society of Cardiology to provide a perspective on the current state of technical advances and clinical cardiac magnetic resonance applications and to inform cardiologists how to implement their clinical and diagnostic pathway with the introduction of this technique in the clinical practice. Appropriateness criteria were defined using a score system: score 1-3 = inappropriate (test is not generally acceptable and is not a reasonable approach for the indication), score 4-6 = uncertain (test may be generally acceptable and may be a reasonable approach for the indication but more research and/or patient information is needed to classify the indication definitively) and score 7-9 = appropriate (test is generally acceptable and is a reasonable approach for the indication)...
January 13, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28092107/rsv-associated-hospitalizations-in-children-in-karachi-pakistan-implications-for-vaccine-prevention-strategies
#15
Asad Ali, Mohammad Tahir Yousafzai, Rabbia Waris, Fatima Jafri, Fatima Aziz, Imran Naeem Abbasi, Anita Zaidi
Major progress is being made in vaccines against Respiratory Syncytial Virus (RSV), with multiple vaccine candidates currently in the clinical phase of development. Making an investment case for public sector financing of RSV vaccine will require estimation of burden, cost-effectiveness and impact. The aim of this study is to determine the proportion, age distribution and clinical spectrum of RSV associated hospitalizations in children in Karachi, Pakistan. A three years prospective study was conducted at the Aga Khan University hospital in Karachi, a city of 20 million in south Pakistan, from August 2009 to June 2012...
January 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28090764/incremental-and-infrequent-hemodialysis-a-new-paradigm-for-both-dialysis-initiation-and-conservative-management
#16
Connie M Rhee, Mehrdad Ghahremani-Ghajar, Yoshitsugu Obi, Kamyar Kalantar-Zadeh
Registry or national dialysis data show that a sizeable proportion of contemporary dialysis patients have substantial levels of residual kidney function especially upon transitioning to dialysis therapy. However, among incident hemodialysis patients, the prevailing paradigm has been to initiate "full-dose" thrice-weekly treatment schedules irrespective of native kidney function in most developed countries. Recognizing the benefits of residual kidney function upon the health and survival of dialysis patients, there has been growing interest in incremental hemodialysis, in which dialysis frequency and dose are tailored according to the degree of patients' residual kidney function...
January 13, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28090618/alan-blum-on-why-physicians-need-to-be-more-active-and-creative-in-the-clinic-classroom-and-community-in-smoking-prevention-and-cessation
#17
Alan Blum
No abstract text is available yet for this article.
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090471/hair-zinc-level-analysis-and-correlative-micronutrients-in-children-presenting-with-malnutrition-and-poor-growth
#18
Tae Hwan Han, Jin Lee, Yong Joo Kim
PURPOSE: Zinc deficiency can induce serious clinical problems in the gastrointestinal (GI) system and immune system and can affect growth and development. It is more severe in younger patients. Chronic zinc deficiency is reflected more precisely in hair than in serum. We studied hair zinc levels and other hair and serum micronutrients in chronic malnourished children to identify which micronutrients are affected or correlated with the other ones. METHODS: Hair mineral analyses were performed in 56 children (age, 1-15 years) presenting with malnutrition, poor growth, poor appetite, anorexia, with/without other GI symptoms (diarrhea, abdominal pain, constipation) from August 2012 to March 2015...
December 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28090465/does-intrauterine-injection-of-low-molecular-weight-heparin-improve-the-clinical-pregnancy-rate-in-intracytoplasmic-sperm-injection
#19
Ahmed Mohamed Kamel, Yahia El-Faissal, Mona Aboulghar, Ragaa Mansour, Gamal I Serour, Mohamed Aboulghar
OBJECTIVE: Heparin can modulate proteins, and influence processes involved in implantation and trophoblastic development. This study aimed to assess the improvement of clinical pregnancy and implantation rates after local intrauterine injection of low-molecular-weight heparin (LMWH) in patients undergoing intracytoplasmic sperm injection (ICSI). METHODS: A randomised case/control design was followed in women scheduled for ICSI. The study arm was injected with intrauterine LMWH during mock embryo transfer immediately following the ovum pickup procedure, while the control arm was given an intrauterine injection with a similar volume of tissue culture media...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28090463/efficacy-of-oxytocin-antagonist-infusion-in-improving-in-vitro-fertilization-outcomes-on-the-day-of-embryo-transfer-a-meta-analysis
#20
Seul Ki Kim, E-Jung Han, Sun Mie Kim, Jung Ryeol Lee, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim
OBJECTIVE: Uterine contraction induced by the embryo transfer (ET) process has an adverse effect on embryo implantation. The aim of this study was to determine the effect of oxytocin antagonist supplementation on the day of ET on in vitro fertilization outcomes via a meta-analysis. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs). Four online databases (Embase, Medline, PubMed, and Cochrane Library) were searched through May 2015 for RCTs that investigated oxytocin antagonist supplementation on the day of ET...
December 2016: Clinical and Experimental Reproductive Medicine
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