Weimin Guo, Mingxue Chen, Zhenyong Wang, Yue Tian, Jinxuan Zheng, Shuang Gao, Yangyang Li, Yufeng Zheng, Xu Li, Jingxiang Huang, Wei Niu, Shuangpeng Jiang, Chunxiang Hao, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Zehao Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Libo Hao, Xifu Zheng, Shuyun Liu, Quanyi Guo
Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells, meniscus regeneration remains a great challenge in clinic. In this study, we found decellularized meniscal extracellular matrix (MECM) preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells. Moreover, MECM significantly promoted meniscal fibrochondrocytes viability and proliferation, increased the expression of type II collagen and proteoglycans in vitro...
October 2021: Bioactive Materials