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https://www.readbyqxmd.com/read/27900245/image-analysis-assisted-study-of-mitotic-figures-in-oral-epithelial-dysplasia-and-squamous-cell-carcinoma-using-differential-stains
#1
Ankita Tandon, Narendra Nath Singh, V R Brave, Gadiputi Sreedhar
BACKGROUND: Mitosis is a process of cell division resulting in two genetically equivalent daughter cells. Excessive proliferation of cells due to mitosis is the hallmark in pre cancer and cancer. AIMS: This study was conducted to count the number of mitotic figures in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma in both Hematoxylin and Eosin (H&E) and Crystal Violet stained sections. Also the overall number of mitotic figures with both stains were compared along with the evaluation of staining efficacy of both the stains...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27899983/hur-and-podoplanin-expression-is-associated-with-a-high-risk-of-malignant-transformation-in-patients-with-oral-preneoplastic-lesions
#2
Umma Habiba, Tetsuya Kitamura, Aya Yanagawa-Matsuda, Fumihiro Higashino, Kyoko Hida, Yasunori Totsuka, Masanobu Shindoh
The risk of malignant transformation in oral preneoplastic lesions (OPLs) is challenging to assess. The objective of the present study was to determine the expression of ELAV like RNA binding protein 1 (HuR) and podoplanin in OPLs, and to evaluate the use of each protein as biomarkers for the risk assessment of malignant transformations. Immunohistochemistry for HuR and podoplanin was performed on the tissues of 51 patients with OPL, including cases of low grade dysplasia (LGD) and high grade dysplasia (HGD)...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27866683/interventional-laser-surgery-for-oral-potentially-malignant-disorders-a-longitudinal-patient-cohort-study
#3
P J Thomson, M L Goodson, K Cocks, J E Turner
Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Contemporary practice remains unable to predict lesion behaviour or quantify malignant transformation risk. No clear management guidelines exist and it is unclear from the literature whether early diagnosis and intervention prevents cancer...
November 17, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27860386/raman-spectroscopy-can-discriminate-between-normal-dysplastic-and-cancerous-oral-mucosa-a-tissue-engineering-approach
#4
Salman A Mian, Ceyla Yorucu, Muhammad Saad Ullah, Ihtesham U Rehman, Helen E Colley
Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Squamous cell carcinoma, the primary cause of HNC, evolves from normal epithelium through dysplasia before invading the connective tissue to form a carcinoma. However, less than 18% of suspicious oral lesions progress to cancer, with diagnosis currently relying on histopathological evaluation, which is invasive and time consuming. A non-invasive, real-time, point-of-care method could overcome these problems and facilitate regular screening...
November 10, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27849339/immunohistochemical-study-of-p21-and-bcl-2-in-leukoplakia-oral-submucous-fibrosis-and-oral-squamous-cell-carcinoma
#5
Rakesh V Sutariya, Bhari Sharanesha Manjunatha
BACKGROUND: Oral Squamous cell carcinoma (OSCC) results from genetic damage, leading to uncontrolled cell proliferation of damaged cells and the cell death. In the course of its progression, visible changes are taking place at the cellular level (atypical) and the resultant at the tissue level (epithelial dysplasia). OBJECTIVES: The Aim of the present study was to evaluate and compare the expressions of intensity of p21 and Bcl-2 in Leukoplakia, oralsubmucous fibrosis (OSMF) and oral squamous cell carcinoma...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27790587/immunohistochemical-expression-of-cyclin-b1-in-epithelial-hyperplasia-dysplasia-and-oral-squamous-cell-carcinomas-a-comparative-study
#6
Kochli Channappa Niranjan, Amsavardani Tayaar, G S Kumar, Rekha Krishnapillai, Kaveri Hallikeri, Santosh Hunasgi
INTRODUCTION: Cyclin B1 is important in the cell cycle progression from G2 to M phase. Cyclin B1 binds to CDC2, which then becomes dephosphorylated and gets relocated to the nucleus, ensuring the transition toward mitosis. AIM: Over expression of Cyclin B1, has been reported more recently in breast, colon, prostate, oral and esophageal carcinomas. Thus, the aim of the present study was to examine the expression of Cyclin B1 in hyperplasia, dysplasia and Oral Squamous Cell Carcinomas (OSCC)...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27734976/human-papillomavirus-and-head-and-neck-carcinomas-focus-on-evidence-in-the-babel-of-published-data
#7
P Morbini, M Benazzo
Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a well-defined entity mostly affecting young to middle-aged male non-smokers. It is generally associated with a favourable outcome, and for this reason a less intensive therapeutic approach has been proposed for this subset of patients. The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in most Western countries, but detailed epidemiological data are not available for the Italian population. Furthermore, among other head and neck regions, a smaller proportion of oral high-grade dysplasia and cancers seems to depend on HPV infection, whereas its role in laryngeal cancer is recognised as less relevant...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27721611/human-mutl-homolog-1-immunoexpression-in-oral-leukoplakia-and-oral-squamous-cell-carcinoma-a-prospective-study-in-indian-population
#8
Narendra T Chaudhari, Jagdish V Tupkari, Tabita Joy, Manisha S Ahire
BACKGROUND: Mammalian mismatch repair system is responsible for maintaining genomic stability during repeated duplications, and human MutL homolog 1 (hMLH1) protein constitutes an important part of it. Various isolated studies have reported the altered expression of hMLH1 in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). Research is lacking in the quantitative estimation and comparison of hMLH1 expression in OL and OSCC. AIMS: To evaluate, quantify and compare hMLH1 immunoexpression in normal oral mucosa, OL and OSCC...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27721610/caspase-3-expression-in-normal-oral-epithelium-oral-submucous-fibrosis-and-oral-squamous-cell-carcinoma
#9
Veeran Veeravarmal, Ravi David Austin, Nagini Siddavaram, Sambanthan Thiruneelakandan, Mohamed Hanifa Mohamed Nassar
CONTEXT: The epithelium atrophy, as the oral submucous fibrosis (OSMF) progresses, is believed to be an after effect of stromal fibrosis, hyalinization, decrease in vascularity and cellularity and is considered as "ischemic atrophy." Due to hypoxia, caspase-3 get activation and subsequent decrease in viable cell count can occur. AIMS AND OBJECTIVES: To determine caspase-3 expression in various grades of OSMF and oral squamous cell carcinoma (OSCC) to find out whether upregulation of apoptosis is responsible for the epithelial changes in OSMF...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27658890/a-randomized-phase-iib-trial-of-myo-inositol-in-smokers-with-bronchial-dysplasia
#10
Stephen Lam, Sumithra J Mandrekar, Yaron Gesthalter, Katie L Allen Ziegler, Drew K Seisler, David E Midthun, Jenny T Mao, Marie Christine Aubry, Annette McWilliams, Don D Sin, Tawimas Shaipanich, Gang Liu, Evan Johnson, Andrea Bild, Marc E Lenburg, Diana N Ionescu, John Mayo, Joanne Eunhee Yi, Henry Tazelaar, William S Harmsen, Judith Smith, Avrum E Spira, Jennifer Beane, Paul J Limburg, Eva Szabo
Previous preclinical studies and a phase I clinical trial suggested that myo-inositol may be a safe and effective lung cancer chemopreventive agent. We conducted a randomized, double blind, placebo-controlled phase IIb study to determine the chemopreventive effects of myo-inositol in smokers with bronchial dysplasia. Smokers with ≥1 site of dysplasia identified by autofluorescence bronchoscopy-directed biopsy were randomly assigned to receive oral placebo or myo-inositol, 9 g once a day for 2 weeks, and then twice a day for 6 months...
December 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27595730/oral-leukoplakia-clinicopathological-correlation-and-its-relevance-to-regional-tobacco-related-habit-index
#11
Prashanth Shetty, Shweta Hegde, K S Vinod, Salona Kalra, Prasoon Goyal, Mimansha Patel
INTRODUCTION: A case control study was carried out to evaluate the synergistic effects of habits quantified by habit index and its effect and severity on the clinicopathological features of oral leukoplakia in a cohort of 100 patients visiting Triveni Dental College, Bilaspur, Chhattisgarh, India. MATERIALS AND METHODS: One hundred patients indulging in tobacco-related habits (smoking and smokeless forms) were categorized into two groups: A case/experimental group consisting of 50 patients presenting with oral leukoplakia lesion and a control group consisting of 50 patients with no clinical signs of oral leukoplakia...
2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27531883/should-severe-epithelial-dysplasia-be-treated
#12
Lewei Zhang, Tarinee Lubpairee, Denise M Laronde, Miriam P Rosin
OBJECTIVE: To identify clinical features associated with progression of primary severe epithelial dysplasia into invasive squamous cell carcinoma (SCC). DESIGN: Longitudinal population-based study. SETTING: Oral dysplasia clinics. PATIENTS: This study involved 118 patients with 118 severe dysplasia who were prospectively enrolled between 1996 and 2014, and the lesions were either completely removed surgically (treated) or actively followed (untreated)...
September 2016: Oral Oncology
https://www.readbyqxmd.com/read/27529842/lamc2-is-a-predictive-marker-for-the-malignant-progression-of-leukoplakia
#13
Chi Thi Kim Nguyen, Takeshi Okamura, Kei-Ichi Morita, Satoshi Yamaguchi, Hiroyuki Harada, Yoshio Miki, Toshiyuki Izumo, Kou Kayamori, Akira Yamaguchi, Kei Sakamoto
BACKGROUND: LAMC2 plays an important role in cancer invasion. The aim of this study was to (i) compare the immunoexpression of LAMC2 in different stages of oral squamous cell carcinoma (OSCC), early and advanced, and (ii) to evaluate LAMC2 as a marker of malignant transformation in leukoplakia. MATERIALS AND METHODS: The expression of LAMC2 was examined by immunohistochemistry in 50 surgical specimens of advanced OSCC assembled as tissue microarrays, and by cDNA microarray in 43 surgical specimens of advanced OSCC...
August 16, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27508095/micrornas-208b-3p-204-5p-129-2-3p-and-3065-5p-as-predictive-markers-of-oral-leukoplakia-that-progress-to-cancer
#14
Elizabeth Philipone, Angela J Yoon, Shuang Wang, Jing Shen, Yen Chen Kevin Ko, Jill M Sink, Andrew Rockafellow, Nathanel A Shammay, Regina M Santella
Leukoplakia is the most common precursor lesion of oral squamous cell carcinoma (OSCC). Currently, the risk of progression to OSCC is assessed based on histopathologic examination alone. However, this method fails to identify the subset of microscopically innocuous leukoplakia that ultimately transforms to OSCC. The aim of this study was to determine if microRNAs (miRNAs) can be utilized to identify non- and low-grade dysplastic oral lesions at risk for cancer progression. A retrospective study of genome-wide miRNA expression level analyses was performed in the training cohort (n=20) using deep sequencing formalin-fixed paraffin embedded incisional biopsy tissues from patients with oral leukoplakic lesions diagnosed with non- or low-grade dysplasia and known clinical outcome...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27429590/expression-of-srsf3-is-correlated-with-carcinogenesis-and-progression-of-oral-squamous-cell-carcinoma
#15
Liu Peiqi, Guo Zhaozhong, Yin Yaotian, Jia Jun, Guo Jihua, Jia Rong
OBJECTIVE: Oral squamous cell carcinoma (OSCC) is the most common malignancy of head and neck with high mortality rates. The mechanisms of initiation and development of OSCC remain largely unknown. Dysregulated alternative splicing of pre-mRNA has been associated with OSCC. Splicing factor SRSF3 is a proto-oncogene and overexpressed in multiple cancers. The aim of this study was to uncover the relationship between SRSF3 and carcinogenesis and progression of oral squamous cell carcinoma...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27421772/subcellular-differential-expression-of-ep-icd-in-oral-dysplasia-and-cancer-is-associated-with-disease-progression-and-prognosis
#16
Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J Witterick, Paul G Walfish, Ranju Ralhan
BACKGROUND: Identification of patients with oral dysplasia at high risk of cancer development and oral squamous cell carcinoma (OSCC) at increased risk of disease recurrence will enable rigorous personalized treatment. Regulated intramembranous proteolysis of Epithelial cell adhesion molecule (EpCAM) resulting in release of its intracellular domain Ep-ICD into cytoplasm and nucleus triggers oncogenic signaling. We analyzed the expression of Ep-ICD in oral dysplasia and cancer and determined its clinical significance in disease progression and prognosis...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27401887/cost-effectiveness-analysis-of-using-loss-of-heterozygosity-to-manage-premalignant-oral-dysplasia-in-british-columbia-canada
#17
Ian Cromwell, Dean A Regier, Stuart J Peacock, Catherine F Poh
BACKGROUND: Management of low-grade oral dysplasias (LGDs) is complicated, as only a small percentage of lesions will progress to invasive disease. The current standard of care requires patients to undergo regular monitoring of their lesions, with intervention occurring as a response to meaningful clinical changes. Recent improvements in molecular technologies and understanding of the biology of LGDs may allow clinicians to manage lesions based on their genome-guided risk. METHODS: We used a decision-analytic Markov model to estimate the cost-effectiveness of risk-stratified care using a genomic assay...
September 2016: Oncologist
https://www.readbyqxmd.com/read/27356725/genetic-abnormalities-in-oral-leukoplakia-and-oral-cancer-progression
#18
Tae Jun Kil, Hyun Sil Kim, Hyung Jun Kim, Woong Nam, In-Ho Cha
BACKGROUND: The cancer progression of oral leukoplakia is an important watchpoint in the follow-up observation of the patients. However, potential malignancies of oral leukoplakia cannot be estimated by histopathologic assessment alone. We evaluated genetic abnormalities at the level of copy number variation (CNV) to investigate the risk for developing cancer in oral leukoplakias. MATERIALS AND METHODS: The current study used 27 oral leukoplakias with histological evidence of dysplasia...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27349317/aberrant-dkk3-expression-in-the-oral-leukoplakia-and-oral-submucous-fibrosis-a-comparative-immunohistochemical-study
#19
T Al-Dhohorah, M Mashrah, Z Yao, J Huang
We aimed to assess and compare the expression of Dickkopf homolog 3 (DKK3), a possible tumor suppressor gene (TSG), in oral leukoplakia (OLK) and oral submucous fibrosis (OSF) using immunohistochemistry. Seventy-five cases of normal oral mucosa (NOM), OLK, OSF, and squamous cell carcinoma (OSCC) were studied. DKK3 was expressed in all cases of NOM, OLK and OSCC. There was steady increases in the percentage of the positive cells progressing toward OSCC. The expression was localized in the cytoplasm and cell membrane of cell affected by OLK with mild dysplasia and OLK with severe dysplasia...
2016: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/27220821/towards-monitoring-dysplastic-progression-in-the-oral-cavity-using-a-hybrid-fiber-bundle-imaging-and-spectroscopy-probe
#20
Gage J Greening, Haley M James, Mary K Dierks, Nontapoth Vongkittiargorn, Samantha M Osterholm, Narasimhan Rajaram, Timothy J Muldoon
Intraepithelial dysplasia of the oral mucosa typically originates in the proliferative cell layer at the basement membrane and extends to the upper epithelial layers as the disease progresses. Detection of malignancies typically occurs upon visual inspection by non-specialists at a late-stage. In this manuscript, we validate a quantitative hybrid imaging and spectroscopy microendoscope to monitor dysplastic progression within the oral cavity microenvironment in a phantom and pre-clinical study. We use an empirical model to quantify optical properties and sampling depth from sub-diffuse reflectance spectra (450-750 nm) at two source-detector separations (374 and 730 μm)...
2016: Scientific Reports
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