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https://www.readbyqxmd.com/read/28635497/desynchronisation-of-auditory-steady-state-responses-related-to-changes-in-interaural-phase-differences-an-objective-measure-of-binaural-hearing
#1
Charlotte Vercammen, Astrid van Wieringen, Jan Wouters, Tom Francart
OBJECTIVE: Binaural processing can be measured objectively as a desynchronisation of phase-locked neural activity to changes in interaural phase differences (IPDs). This was reported in a magnetoencephalography study for 40 Hz amplitude modulated tones. The goal of this study was to measure this desynchronisation using electroencephalography and explore the outcomes for different modulation frequencies. DESIGN: Auditory steady-state responses (ASSRs) were recorded to pure tones, amplitude modulated at 20, 40 or 80 Hz...
February 14, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28626013/sleep-disrupts-high-level-speech-parsing-despite-significant-basic-auditory-processing
#2
Shiri Makov, Omer Sharon, Nai Ding, Michal Ben-Shachar, Yuval Nir, Elana Zion Golumbic
The extent to which the sleeping brain processes sensory information remains unclear. This is particularly true for continuous and complex stimuli, such as speech, in which information is organized into hierarchically embedded structures. Recently, novel metrics for assessing the neural representation of continuous speech have been developed, using non-invasive brain recordings. Those were so far tested during wakefulness. Here we investigated, for the first time, the sleeping brain's capacity to process continuous speech at different hierarchical levels, using a newly developed Concurrent Hierarchical Tracking (CHT) approach that can online monitor the neural representation and processing-depth of continuous speech...
June 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28613191/collective-behaviors-of-mobile-robots-beyond-the-nearest-neighbor-rules-with-switching-topology
#3
Boda Ning, Qing-Long Han, Zongyu Zuo, Jiong Jin, Jinchuan Zheng
This paper is concerned with the collective behaviors of robots beyond the nearest neighbor rules, i.e., dispersion and flocking, when robots interact with others by applying an acute angle test (AAT)-based interaction rule. Different from a conventional nearest neighbor rule or its variations, the AAT-based interaction rule allows interactions with some far-neighbors and excludes unnecessary nearest neighbors. The resulting dispersion and flocking hold the advantages of scalability, connectivity, robustness, and effective area coverage...
June 8, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28611282/the-4-plus-2-rituximab-protocol-makes-maintenance-treatment-unneeded-in-patients-with-refractory-anca-associated-vasculitis-a-10-year-observation-study
#4
Dario Roccatello, Savino Sciascia, Daniela Rossi, Mirella Alpa, Carla Naretto, Massimo Radin, Roberta Fenoglio, Simone Baldovino, Elisa Menegatti
BACKGROUND: ANCA associated vasculitides (AAV) often present with a chronic relapsing course. Relapse leads to increased immunosuppressive exposure and consequent toxicity. While two randomized controlled trials have shown rituximab (RTX) to be the most effective induction treatment in patients with relapsing disease, the optimal treatment duration and RTX dose remain debated. Whether to administer a maintenance dose to every patient, at a fixed time interval or on the basis of B cell count and ANCA titre or only when disease manifestations do occur is still debated as well...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28601153/equine-chorionic-gonadotropin-increases-fertility-of-grazing-dairy-cows-that-receive-fixed-time-artificial-insemination-in-the-early-but-not-later-postpartum-period
#5
Alexandre B Prata, Guilherme C S Pontes, Pedro Leopoldo J Monteiro, Jéssica N Drum, Milo C Wiltbank, Roberto Sartori
This study evaluated effects of equine chorionic gonadotropin (eCG) on fertility of 679 crossbred (Bos taurus x Bos indicus) lactating grazing cows synchronized for fixed-time AI (FTAI). At a random day of the estrous cycle cows received an intravaginal progesterone (P4) implant, 2 mg estradiol benzoate (EB) and 100 μg gonadorelin (D0-AM). On D7-AM, cows received 0.5 mg sodium cloprostenol and were randomly assigned into two treatments: eCG (n = 340; 400 IU eCG on D7), or Control (n = 339; no eCG). On D8-PM, P4 implants were removed and cows received 0...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28591613/analysis-of-noise-mechanisms-in-cell-size-control
#6
Saurabh Modi, Cesar Augusto Vargas-Garcia, Khem Raj Ghusinga, Abhyudai Singh
At the single-cell level, noise arises from multiple sources, such as inherent stochasticity of biomolecular processes, random partitioning of resources at division, and fluctuations in cellular growth rates. How these diverse noise mechanisms combine to drive variations in cell size within an isoclonal population is not well understood. Here, we investigate the contributions of different noise sources in well-known paradigms of cell-size control, such as adder (division occurs after adding a fixed size from birth), sizer (division occurs after reaching a size threshold), and timer (division occurs after a fixed time from birth)...
June 6, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28588078/walking-as-a-window-to-risk-and-resiliency
#7
Karen P Alexander
Walking is fundamental to preserving health and independence. An individual's usual pace of walking is also recognized as an indicator of health, risk for dependency, and a predictor of long-term survival. Reducing gait speed by just 0.1m/sec provides important information about outcomes in older adults that goes beyond chronologic age, sex, comorbidity, and self-reported function combined. This small reduction in gate speed is significant because each individual sets the pace necessary to accommodate a host of integrated functions that allow him or her to walk...
June 6, 2017: Circulation
https://www.readbyqxmd.com/read/28583595/the-copper-transporter-slc31a1-ctr1-is-expressed-in-bovine-spermatozoa-and-oocytes-copper-in-ivf-medium-improves-sperm-quality
#8
J P Anchordoquy, J M Anchordoquy, A M Pascua, N Nikoloff, P Peral-García, C C Furnus
Adequate dietary intake of copper (Cu) is required for normal reproductive performance in cattle. The objective of this study was to investigate the pregnancy rates from cattle with deficient, marginal and adequate Cu plasma concentration at the beginning of artificial insemination protocol. Moreover, we determined Cu concentrations present in bovine oviductal fluid (OF), and the effects of Cu on fertilizing ability of bovine spermatozoa. Also, the presence of Cu transporter, SLC31A1 (also known as CTR1), in spermatozoa and in vitro matured oocyte were investigated...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28579759/a-randomized-trial-of-individual-versus-group-format-exercise-and-self-management-in-individuals-with-parkinson-s-disease-and-comorbid-depression
#9
Martha Sajatovic, Angela L Ridgel, Ellen M Walter, Curtis M Tatsuoka, Kari Colón-Zimmermann, Riane K Ramsey, Elisabeth Welter, Steven A Gunzler, Christina M Whitney, Benjamin L Walter
BACKGROUND: Depression is common in people with Parkinson's disease (PD), and exercise is known to improve depression and PD. However, lack of motivation and low self-efficacy can make exercise difficult for people with PD and comorbid depression (PD-Dep). A combined group exercise and chronic disease self-management (CDSM) program may improve the likeli-hood that individuals will engage in exercise and will show a reduction in depression symptoms. The purpose of this study was to compare changes in depression in PD-Dep between individual versus group exercise plus CDSM and to examine participant adherence and perception of the interventions...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28578044/comparison-of-static-and-dynamic-sensory-product-characterizations-based-on-check-all-that-apply-questions-with-consumers
#10
Florencia Alcaire, Lucía Antúnez, Leticia Vidal, Shari Zorn, Ana Giménez, John C Castura, Gastón Ares
The aim of the present work was to compare static and dynamic sensory product characterizations based on check-all-that-apply (CATA) questions with consumers. Three studies involving a total of 310 consumers were carried out. In each study, a between-subjects experimental design was used to compare static sensory characterizations obtained using CATA questions with dynamic characterizations over a relatively short time period using temporal CATA (TCATA). Three different product categories were evaluated (orange juice, strawberry yogurt, and vanilla milk desserts) using 6-11 sensory terms...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28539253/documenting-the-kinetic-time-course-of-lambda-cyhalothrin-metabolites-in-orally-exposed-volunteers-for-the-interpretation-of-biomonitoring-data
#11
Rania Khemiri, Jonathan Côté, Hamadi Fetoui, Michèle Bouchard
Lambda-cyhalothrin is a pyrethroid pesticide largely used in agriculture. Exposure assessment can be performed by measuring key urinary metabolites. For a proper use of biomonitoring data, it is however important to gain information on the toxicokinetics of these key biomarkers of exposure. A human volunteer study was performed to document the plasma and urinary time courses of major lambda-cyhalothrin metabolites. Seven volunteers ingested 0.025mgkg(-1) body weight of lambda-cyhalothrin. Blood samples were withdrawn prior to dosing and at fixed time periods over the 72 h-period following ingestion and complete urine voids were collected pre-exposure and at pre-established intervals over 84h post-dosing...
July 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28532243/transabdominal-ultrasonography-defined-optimal-and-definitive-bladder-filling-protocol-with-time-trends-during-pelvic-radiation-for-cervical-cancer
#12
Mahantshetty Umesh, Deepak P Kumar, Pranav Chadha, Rajiv Choudary, Seema Kembhavi, Meenakshi Thakur, Engineer Reena, Supriya Chopra, Shyamkishore Shrivastava
PURPOSE: Advanced radiotherapy techniques have emphasized on the importance of accurate target volume localization and delineation. The aim of this study was to determine time taken to achieve moderate bladder volume under physiological conditions, using transabdominal ultrasound. MATERIALS AND METHODS: Patients with cervical cancer undergoing radical radiation with or without concomitant chemotherapy underwent serial ultrasound to estimate bladder filling. With a strict bladder protocol of consuming 1000 mL of water orally over 30 minutes after emptying the bladder, ultrasound was done after 45 minutes from bladder emptying time and repeated at 15-minute interval till 300 (25) mL filling was achieved and repeated every week...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28531198/a-real-time-traffic-control-method-for-the-intersection-with-pre-signals-under-the-phase-swap-sorting-strategy
#13
Yiming Bie, Zhiyuan Liu, Yinhai Wang
To deal with the conflicts between left-turn and through traffic streams and increase the discharge capacity, this paper addresses the pre-signal which is implemented at a signalized intersection. Such an intersection with pre-signal is termed as a tandem intersection. For the tandem intersection, phase swap sorting strategy is deemed as the most effective phasing scheme in view of some exclusive merits, such as easier compliance of drivers, and shorter sorting area. However, a major limitation of the phase swap sorting strategy is not considered in previous studies: if one or more vehicle is left at the sorting area after the signal light turns to red, the capacity of the approach would be dramatically dropped...
2017: PloS One
https://www.readbyqxmd.com/read/28529387/cross-sectional-surveys-inferring-total-eventual-time-in-current-state-using-only-elapsed-time-to-date
#14
Richard C Larson
We focus on snapshot surveying of sub-populations whose members are in a temporary state and where one of the questions asked is the elapsed time already spent in that state. From these answers we develop probabilistic and statistical procedures to estimate the distribution of total time that will eventually be spent in that state by any random individual who enters the state. The method relies on a selection bias often found in temporal sampling, sometimes called "random incidence" or "longevity bias." We develop results for several types of sampling, including random and fixed times of surveying, random and fixed times of entering the state, and sampling only those who have already spent some minimal specified time in the targeted state...
March 2017: Socio-economic Planning Sciences
https://www.readbyqxmd.com/read/28521879/a-quick-simple-method-for-detecting-circulating-fluorescent-advanced-glycation-end-products-correlation-with-in-vitro-and-in-vivo-non-enzymatic-glycation
#15
Marika Villa, Mariacristina Parravano, Arianna Micheli, Lucia Gaddini, Andrea Matteucci, Cinzia Mallozzi, Francesco Facchiano, Fiorella Malchiodi-Albedi, Flavia Pricci
OBJECTIVE: Advanced glycation end-products (AGEs) constitute a highly heterogeneous family of compounds, relevant in the pathogenesis of diabetic complications, which could represent efficient biomarkers of disease progression and drug response. Unfortunately, due to their chemical heterogeneity, no method has been validated to faithfully monitor their levels in the course of the disease. In this study, we refine a procedure to quantitatively analyze fluorescent AGEs (fAGEs), a subset considered remarkably representative of the entire AGE family, and measure them in in vitro glycated BSA (gBSA) and in plasma and vitreous of diabetic rats, for testing its use to possibly quantify circulating AGEs in patients, as markers of metabolic control...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28521255/pharmacokinetics-of-ketamine-and-norketamine-enantiomers-after-racemic-or-s-ketamine-iv-bolus-administration-in-dogs-during-sevoflurane-anaesthesia
#16
Noemi Romagnoli, Rima N Bektas, Annette P Kutter, Andrea Barbarossa, Paola Roncada, Sonja Hartnack, Regula Bettschart-Wolfensberger
The aims of this study were to measure plasma levels of R- and S-ketamine and their major metabolites R- and S-norketamine following single intravenous bolus administration of racemic or S-ketamine in sevoflurane anaesthetised dogs and to calculate the relevant pharmacokinetic profiles. Six adult healthy beagle dogs were used in the study. An intravenous bolus of 4mg/kg racemic ketamine (RS-KET) or 2mg/kg S-ketamine (S-KET) was administered, with a three-weeks washout period between treatments. Venous blood samples were collected at fixed times until 900min and R- and S-ketamine as well as R- and S-norketamine plasma levels determined by liquid chromatography coupled with tandem mass spectrometry...
May 6, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28514324/use-of-the-fluid-challenge-in-critically-ill-adult-patients-a-systematic-review
#17
Antonio Messina, Federico Longhini, Corinne Coppo, Aline Pagni, Ramona Lungu, Chiara Ronco, Marco Ambrogio Cattaneo, Simone Dore, Giovanni Sotgiu, Paolo Navalesi
The fluid challenge (FC) aims at identifying patients in whom fluid administration improves hemodynamics. Although the FC has been extensively studied, the implementation and definition of improvement are not standardized. This systematic review of studies published between January 1, 1994 and December 31, 2014 characterizes these key components of the FC for critically ill adult patients, as described in the medical literature in the last 20 years. A literature search was performed using MEDLINE, Embase, and Cochrane...
May 12, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28513826/noncontingent-reinforcement-without-extinction-plus-differential-reinforcement-of-alternative-behavior-during-treatment-of-problem-behavior
#18
Jennifer N Fritz, Lynsey M Jackson, Nicole A Stiefler, Barbara S Wimberly, Amy R Richardson
The effects of noncontingent reinforcement (NCR) without extinction during treatment of problem behavior maintained by social positive reinforcement were evaluated for five individuals diagnosed with autism spectrum disorder. A continuous NCR schedule was gradually thinned to a fixed-time 5-min schedule. If problem behavior increased during NCR schedule thinning, a continuous NCR schedule was reinstated and NCR schedule thinning was repeated with differential reinforcement of alternative behavior (DRA) included...
May 17, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28501674/target-attainment-with-continuous-dosing-of-piperacillin-tazobactam-in-critical-illness-a-prospective-observational-study
#19
Heleen Aardema, Prashant Nannan Panday, Mireille Wessels, Kay van Hateren, Willem Dieperink, Jos G W Kosterink, Jan-Willem Alffenaar, Jan G Zijlstra
Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the unpredictable pharmacokinetic profile of this patient population. Several studies have shown intermittent dosing to often yield inadequate drug concentrations. Continuous dosing is an attractive alternative from a pharmacodynamic point of view. This study evaluated whether, during continuous dosing, piperacillin concentrations reached and maintained a pre-defined target in critically ill patients. Adult patients treated with piperacillin by continuous dosing in the intensive care unit of a university medical centre in The Netherlands were prospectively studied...
July 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28487444/the-longitudinal-transcriptional-response-to-neoadjuvant-chemotherapy-with-and-without-bevacizumab-in-breast-cancer
#20
Laxmi Silwal-Pandit, Silje Nord, Hedda von der Lippe Gythfeldt, Elen K Møller, Thomas Fleischer, Einar Rødland, Marit Krohn, Elin Borgen, Øystein Garred, Tone Olsen, Phuong Vu, Helle Skjerven, Anne Fangberget, Marit M Holmen, Ellen Schlichting, Elisabeth Wille, Mette Nordberg Stokke, Hans Kristian Moen Vollan, Vessela N Kristensen, Anita Langerød, Steinar Lundgren, Erik A Wist, Bjørn Naume, Ole Christian Lingjerde, Anne-Lise Borresen-Dale, Olav Engebraaten
Chemotherapy induced alterations to gene expression are due to transcriptional reprogramming of tumor cells or subclonal adaptations to treatment. The effect on whole-transcriptome mRNA expression was investigated in a randomized phase II clinical trial to assess the effect of neoadjuvant chemotherapy with the addition of bevacizumab. <br />Experimental Design: Tumor biopsies and whole-transcriptome mRNA profiles were obtained at three fixed time points with 66 patients in each arm.  Altogether, 358 specimens from 132 patients were available, representing the transcriptional state before treatment start, at 12 weeks and after treatment (25 weeks)...
May 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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