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https://www.readbyqxmd.com/read/28521879/a-quick-simple-method-for-detecting-circulating-fluorescent-advanced-glycation-end-products-correlation-with-in-vitro-and-in-vivo-non-enzymatic-glycation
#1
Marika Villa, Mariacristina Parravano, Arianna Micheli, Lucia Gaddini, Andrea Matteucci, Cinzia Mallozzi, Francesco Facchiano, Fiorella Malchiodi-Albedi, Flavia Pricci
OBJECTIVE: Advanced glycation end-products (AGEs) constitute a highly heterogeneous family of compounds, relevant in the pathogenesis of diabetic complications, which could represent efficient biomarkers of disease progression and drug response. Unfortunately, due to their chemical heterogeneity, no method has been validated to faithfully monitor their levels in the course of the disease. In this study, we refine a procedure to quantitatively analyze fluorescent AGEs (fAGEs), a subset considered remarkably representative of the entire AGE family, and measure them in in vitro glycated BSA (gBSA) and in plasma and vitreous of diabetic rats, for testing its use to possibly quantify circulating AGEs in patients, as markers of metabolic control...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28521255/pharmacokinetics-of-ketamine-and-norketamine-enantiomers-after-racemic-or-s-ketamine-iv-bolus-administration-in-dogs-during-sevoflurane-anaesthesia
#2
Noemi Romagnoli, Rima N Bektas, Annette P Kutter, Andrea Barbarossa, Paola Roncada, Sonja Hartnack, Regula Bettschart-Wolfensberger
The aims of this study were to measure plasma levels of R- and S-ketamine and their major metabolites R- and S-norketamine following single intravenous bolus administration of racemic or S-ketamine in sevoflurane anaesthetised dogs and to calculate the relevant pharmacokinetic profiles. Six adult healthy beagle dogs were used in the study. An intravenous bolus of 4mg/kg racemic ketamine (RS-KET) or 2mg/kg S-ketamine (S-KET) was administered, with a three-weeks washout period between treatments. Venous blood samples were collected at fixed times until 900min and R- and S-ketamine as well as R- and S-norketamine plasma levels determined by liquid chromatography coupled with tandem mass spectrometry...
May 6, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28514324/use-of-the-fluid-challenge-in-critically-ill-adult-patients-a-systematic-review
#3
Antonio Messina, Federico Longhini, Corinne Coppo, Aline Pagni, Ramona Lungu, Chiara Ronco, Marco Ambrogio Cattaneo, Simone Dore, Giovanni Sotgiu, Paolo Navalesi
The fluid challenge (FC) aims at identifying patients in whom fluid administration improves hemodynamics. Although the FC has been extensively studied, the implementation and definition of improvement are not standardized. This systematic review of studies published between January 1, 1994 and December 31, 2014 characterizes these key components of the FC for critically ill adult patients, as described in the medical literature in the last 20 years. A literature search was performed using MEDLINE, Embase, and Cochrane...
May 12, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28513826/noncontingent-reinforcement-without-extinction-plus-differential-reinforcement-of-alternative-behavior-during-treatment-of-problem-behavior
#4
Jennifer N Fritz, Lynsey M Jackson, Nicole A Stiefler, Barbara S Wimberly, Amy R Richardson
The effects of noncontingent reinforcement (NCR) without extinction during treatment of problem behavior maintained by social positive reinforcement were evaluated for five individuals diagnosed with autism spectrum disorder. A continuous NCR schedule was gradually thinned to a fixed-time 5-min schedule. If problem behavior increased during NCR schedule thinning, a continuous NCR schedule was reinstated and NCR schedule thinning was repeated with differential reinforcement of alternative behavior (DRA) included...
May 17, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28501674/target-attainment-with-continuous-dosing-of-piperacillin-tazobactam-in-critical-illness-a-prospective-observational-study
#5
Heleen Aardema, Prashant Nannan Panday, Mireille Wessels, Kay van Hateren, Willem Dieperink, Jos G W Kosterink, Jan-Willem Alffenaar, Jan G Zijlstra
Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the unpredictable pharmacokinetic profile of this patient population. Several studies have shown intermittent dosing to often yield inadequate drug concentrations. Continuous dosing is an attractive alternative from a pharmacodynamic point of view. This study evaluated whether, during continuous dosing, piperacillin concentrations reached and maintained a pre-defined target in critically ill patients. Adult patients treated with piperacillin by continuous dosing in the intensive care unit of a university medical centre in The Netherlands were prospectively studied...
May 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28487444/the-longitudinal-transcriptional-response-to-neoadjuvant-chemotherapy-with-and-without-bevacizumab-in-breast-cancer
#6
Laxmi Silwal-Pandit, Silje Nord, Hedda von der Lippe Gythfeldt, Elen K Møller, Thomas Fleischer, Einar Rødland, Marit Krohn, Elin Borgen, Øystein Garred, Tone Olsen, Phuong Vu, Helle Skjerven, Anne Fangberget, Marit M Holmen, Ellen Schlichting, Elisabeth Wille, Mette Nordberg Stokke, Hans Kristian Moen Vollan, Vessela N Kristensen, Anita Langerød, Steinar Lundgren, Erik A Wist, Bjørn Naume, Ole Christian Lingjerde, Anne-Lise Borresen-Dale, Olav Engebraaten
Chemotherapy induced alterations to gene expression are due to transcriptional reprogramming of tumor cells or subclonal adaptations to treatment. The effect on whole-transcriptome mRNA expression was investigated in a randomized phase II clinical trial to assess the effect of neoadjuvant chemotherapy with the addition of bevacizumab. <br />Experimental Design: Tumor biopsies and whole-transcriptome mRNA profiles were obtained at three fixed time points with 66 patients in each arm.  Altogether, 358 specimens from 132 patients were available, representing the transcriptional state before treatment start, at 12 weeks and after treatment (25 weeks)...
May 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28469566/identifying-the-best-times-for-cognitive-functioning-using-new-methods-matching-university-times-to-undergraduate-chronotypes
#7
M D R Evans, Paul Kelley, Jonathan Kelley
University days generally start at fixed times in the morning, often early morning, without regard to optimal functioning times for students with different chronotypes. Research has shown that later starting times are crucial to high school students' sleep, health, and performance. Shifting the focus to university, this study used two new approaches to determine ranges of start times that optimize cognitive functioning for undergraduates. The first is a survey-based, empirical model (SM), and the second a neuroscience-based, theoretical model (NM)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28464111/circulating-beta-hydroxybutyrate-concentration-may-be-a-predictive-measurement-for-young-cows-that-have-a-greater-probability-to-conceive-at-a-fixed-time-artificial-insemination
#8
J D Hobbs, S R Edwards, E R Cope, Z D McFarlane, K G Pohler, J T Mulliniks
Timing of conception, which has been indicated to be negatively influenced by metabolic dysfunctions, can influence lifetime productivity within the cow herd. Therefore, our objective was to analyze the association of milk production, serum metabolites as an indicator of nutrient status, cow BW and BW change, and calf BW with timing of pregnancy in 183 spring-calving beef cows. Cows were retrospectively classified by timing of pregnancy as cows that were diagnosed pregnant by timed AI (TAI; = 118) or natural breeding (NAT; = 65)...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28456404/effect-of-pre-and-postpartum-supplementation-with-lipid-encapsulated-conjugated-linoleic-acid-on-reproductive-performance-and-the-growth-hormone-insulin-like-growth-factor-i-axis-in-multiparous-high-producing-dairy-cows
#9
Z Csillik, V Faigl, M Keresztes, E Galamb, H M Hammon, A Tröscher, H Fébel, M Kulcsár, F Husvéth, Gy Huszenicza, W R Butler
The objective of the study was to evaluate the effect of prepartum and postpartum (PP) supplementation with 2 isomers of conjugated linoleic acid (CLA) on reproductive parameters and some related metabolic factors in dairy cows. High-producing, multiparous Holstein Friesian cows (n = 60) were allotted to 3 treatment groups: the CLA1 group (n = 20) was supplemented with 70 g of lipid-encapsulated CLA providing 7 g each of cis-9, trans-11 and trans-10, cis-12 CLA from d 21 (d 21) before expected calving until d 7 after artificial insemination (AI), that is, until 77 to 91 d PP; the CLA2 group (n = 20) was supplemented with the same amount of CLA beginning at calving until d 7 after AI; and the control group (n = 20) received an isocaloric, isonitrogenous, and isolipidic diet...
April 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28448064/changes-in-thyroid-hormone-concentrations-during-neonatal-extracorporeal-membrane-oxygenation
#10
L Leeuwen, A F J van Heijst, J van Rosmalen, Y B de Rijke, L W J E Beurskens, D Tibboel, E L T van den Akker, H IJsselstijn
OBJECTIVE: Thyroid hormone concentrations can be disturbed during critical illness. Our aim was to determine changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation (ECMO). STUDY DESIGN: We included 21 ECMO-treated neonates. Age-specific s.d. scores (SDS) of free and total thyroxine (FT4; TT4), reverse and total triiodothyronine (rT3; TT3), thyroid-stimulating hormone (TSH) and thyroxine-binding globulin (TBG) were determined at six fixed time-points...
April 27, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28419643/post-lunch-triglyceridaemia-associates-with-hdlc-and-insulin-resistance-in-fasting-normotriglyceridaemic-menopausal-women
#11
A Sanz-Paris, A Rodriguez-Valle, M A Navarro, J Puzo-Foncillas, J M Arbones-Mainar
OBJECTIVES: Post-prandial hypertriglyceridaemia (P-HTG) is associated with cardiovascular disease. This association is of paramount importance during menopause, which is also related to reduced high-density lipoprotein-cholesterol (HDLc) and elevated triglyceride (TG) levels. We aimed to provide a self-assesing tool to screen for P-HTG in menopausal women who were normotriglyceridaemic at fasting and adhered to a Mediterranean-style eating pattern. METHODS: We performed oral fat loading tests (OFLT) in combination with self-measurements of diurnal capillary TG at fixed time-points (DC-TG) in 29 healthy menopausal women...
April 17, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28415252/clogging-and-jamming-transitions-in-periodic-obstacle-arrays
#12
H T Nguyen, C Reichhardt, C J Olson Reichhardt
We numerically examine clogging transitions for bidisperse disks flowing through a two-dimensional periodic obstacle array. We show that clogging is a probabilistic event that occurs through a transition from a homogeneous flowing state to a heterogeneous or phase-separated jammed state where the disks form dense connected clusters. The probability for clogging to occur during a fixed time increases with increasing particle packing and obstacle number. For driving at different angles with respect to the symmetry direction of the obstacle array, we show that certain directions have a higher clogging susceptibility...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28409223/the-relationships-between-message-passing-pairwise-kermack-mckendrick-and-stochastic-sir-epidemic-models
#13
Robert R Wilkinson, Frank G Ball, Kieran J Sharkey
We consider a very general stochastic model for an SIR epidemic on a network which allows an individual's infectious period, and the time it takes to contact each of its neighbours after becoming infected, to be correlated. We write down the message passing system of equations for this model and prove, for the first time, that it has a unique feasible solution. We also generalise an earlier result by proving that this solution provides a rigorous upper bound for the expected epidemic size (cumulative number of infection events) at any fixed time [Formula: see text]...
April 13, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28408335/optimizing-delivery-of-a-behavioral-pain-intervention-in-cancer-patients-using-a-sequential-multiple-assignment-randomized-trial-smart
#14
Sarah A Kelleher, Caroline S Dorfman, Jen C Plumb Vilardaga, Catherine Majestic, Joseph Winger, Vicky Gandhi, Christine Nunez, Alyssa Van Denburg, Rebecca A Shelby, Shelby D Reed, Susan Murphy, Marie Davidian, Eric B Laber, Gretchen G Kimmick, Kelly W Westbrook, Amy P Abernethy, Tamara J Somers
BACKGROUND/AIMS: Pain is common in cancer patients and results in lower quality of life, depression, poor physical functioning, financial difficulty, and decreased survival time. Behavioral pain interventions are effective and nonpharmacologic. Traditional randomized controlled trials (RCT) test interventions of fixed time and dose, which poorly represent successive treatment decisions in clinical practice. We utilize a novel approach to conduct a RCT, the sequential multiple assignment randomized trial (SMART) design, to provide comparative evidence of: 1) response to differing initial doses of a pain coping skills training (PCST) intervention and 2) intervention dose sequences adjusted based on patient response...
April 11, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28406966/continuous-uniformly-finite-time-exact-disturbance-observer-based-control-for-fixed-time-stabilization-of-nonlinear-systems-with-mismatched-disturbances
#15
Junkang Ni, Chongxin Liu, Hang Liu
This paper presents a continuous composite control scheme to achieve fixed-time stabilization for nonlinear systems with mismatched disturbances. The composite controller is constructed in two steps: First, uniformly finite time exact disturbance observers are proposed to estimate and compensate the disturbances. Then, based on adding a power integrator technique and fixed-time stability theory, continuous fixed-time stable state feedback controller and Lyapunov functions are constructed to achieve global fixed-time system stabilization...
2017: PloS One
https://www.readbyqxmd.com/read/28388472/robust-fixed-time-synchronization-for-uncertain-complex-valued-neural-networks-with-discontinuous-activation-functions
#16
Xiaoshuai Ding, Jinde Cao, Ahmed Alsaedi, Fuad E Alsaadi, Tasawar Hayat
This paper is concerned with the fixed-time synchronization for a class of complex-valued neural networks in the presence of discontinuous activation functions and parameter uncertainties. Fixed-time synchronization not only claims that the considered master-slave system realizes synchronization within a finite time segment, but also requires a uniform upper bound for such time intervals for all initial synchronization errors. To accomplish the target of fixed-time synchronization, a novel feedback control procedure is designed for the slave neural networks...
June 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28364772/a-perturbation-theoretic-approach-to-lagrangian-flow-networks
#17
Naoya Fujiwara, Kathrin Kirchen, Jonathan F Donges, Reik V Donner
Complex network approaches have been successfully applied for studying transport processes in complex systems ranging from road, railway, or airline infrastructures over industrial manufacturing to fluid dynamics. Here, we utilize a generic framework for describing the dynamics of geophysical flows such as ocean currents or atmospheric wind fields in terms of Lagrangian flow networks. In this approach, information on the passive advection of particles is transformed into a Markov chain based on transition probabilities of particles between the volume elements of a given partition of space for a fixed time step...
March 2017: Chaos
https://www.readbyqxmd.com/read/28364661/fixed-time-stability-of-dynamical-systems-and-fixed-time-synchronization-of-coupled-discontinuous-neural-networks
#18
Cheng Hu, Juan Yu, Zhanheng Chen, Haijun Jiang, Tingwen Huang
In this paper, the fixed-time stability of dynamical systems and the fixed-time synchronization of coupled discontinuous neural networks are investigated under the framework of Filippov solution. Firstly, by means of reduction to absurdity, a theorem of fixed-time stability is established and a high-precision estimation of the settling-time is given. It is shown by theoretic proof that the estimation bound of the settling time given in this paper is less conservative and more accurate compared with the classical results...
May 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28355579/stability-of-bk-polyomavirus-igg-seroreactivity-and-its-correlation-with-preceding-viremia
#19
Herman F Wunderink, Els van der Meijden, Caroline S van der Blij-de Brouwer, Hans L Zaaijer, Aloys C M Kroes, Erik W van Zwet, Joris I Rotmans, Mariet C W Feltkamp
BACKGROUND: Recently we showed that the level of BK polyomavirus (BKPyV) IgG seroreactivity in kidney donors predicted viremia and BKPyV-associated nephropathy in kidney transplant recipients (KTRs). This observation could be explained by assuming a direct association between BKPyV seroreactivity and the amount of persistent infectious virus in the renal allograft. OBJECTIVES: Since the renal BKPyV reservoir is probably sowed by viremia during primary BKPyV infection, we systematically analysed the dynamics of BKPyV IgG seroreactivity in relation to preceding BKPyV viremia in KTRs and healthy individuals...
March 19, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28348920/a-new-kinetic-spectrophotometric-method-for-the-quantitation-of-amorolfine
#20
César Soto, Cristian Poza, David Contreras, Jorge Yáñez, Fallon Nacaratte, M Inés Toral
Amorolfine (AOF) is a compound with fungicide activity based on the dual inhibition of growth of the fungal cell membrane, the biosynthesis and accumulation of sterols, and the reduction of ergosterol. In this work a sensitive kinetic and spectrophotometric method for the AOF quantitation based on the AOF oxidation by means of KMnO4 at 30 min (fixed time), pH alkaline, and ionic strength controlled was developed. Measurements of changes in absorbance at 610 nm were used as criterion of the oxidation progress...
2017: Journal of Analytical Methods in Chemistry
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