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https://www.readbyqxmd.com/read/27903655/random-versus-cell-cycle-regulated-replication-initiation-in-bacteria-insights-from-studying-vibrio-cholerae-chromosome-2
#1
REVIEW
Revathy Ramachandran, Jyoti Jha, Johan Paulsson, Dhruba Chattoraj
Bacterial chromosomes initiate replication at a fixed time in the cell cycle, whereas there is generally no particular time for plasmid replication initiation or chromosomal replication initiation from integrated plasmids. In bacteria with divided genomes, the replication system of one of the chromosomes typically resembles that of bacteria with undivided genomes, whereas the remaining chromosomes have plasmid-like replication systems. For example, in Vibrio cholerae, a bacterium with two chromosomes (chromosome 1 [Chr1] and Chr2), the Chr1 system resembles that of the Escherichia coli chromosome, and the Chr2 system resembles that of iteron-based plasmids...
March 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/27898921/using-estrus-detection-patches-to-optimally-time-insemination-improved-pregnancy-risk-in-suckled-beef-cows-enrolled-in-a-fixed-time-artificial-insemination-program
#2
S L Hill, D M Grieger, K C Olson, J R Jaeger, C R Dahlen, G A Bridges, F Dantas, J E Larson, A M Muth-Spurlock, J K Ahola, M C Fischer, G A Perry, E L Larimore, T L Steckler, W D Whittier, J F Currin, J S Stevenson
A multilocation study examined pregnancy risk (PR) after delaying AI in suckled beef cows from 60 to 75 h when estrus had not been detected by 60 h in response to a 7-d CO-Synch + progesterone insert (CIDR) timed AI (TAI) program (d -7: CIDR insert concurrent with an injection of GnRH; d 0: PGF injection and removal of CIDR insert; and GnRH injection at TAI [60 or 75 h after CIDR removal]). A total of 1,611 suckled beef cows at 15 locations in 9 states (CO, IL, KS, MN, MS, MT, ND, SD, and VA) were enrolled...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898908/gonadotropin-releasing-hormone-increased-pregnancy-risk-in-suckled-beef-cows-not-detected-in-estrus-and-subjected-to-a-split-time-artificial-insemination-program
#3
S L Hill, D M Grieger, K C Olson, J R Jaeger, C R Dahlen, M R Crosswhite, N Negrin Pereira, S R Underdahl, B W Neville, J Ahola, M C Fischer, G E Seidel, J S Stevenson
We hypothesized that GnRH would increase pregnancy risk (PR) in a split-time AI program for cows in which estrus was not detected. A total of 1,236 suckled beef cows at 12 locations in 3 states (Colorado, Kansas, and North Dakota) were enrolled. Before applying the fixed-time AI program, BCS was assessed. Cows were treated on d -7 with a progesterone insert concurrent with 100 μg GnRH and on d 0 with 25 mg PGF plus removal of the insert. Estrus-detection patches were affixed to cows at insert removal. Estrus was defined to have occurred when an estrus-detection patch was >50% colored (activated)...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898873/sire-line-of-pigs-affects-weaning-weight-growth-performance-and-carcass-characteristics-of-offspring
#4
L Vermeulen, S Van Beirendonck, A Bulens, J Van Thielen, B Driessen
Today, early weaning is more frequently applied by the modern pig breeder to obtain more litters per year. In addition, more and more European pig breeders apply a batch management system, which allows weaning to occur at fixed time points but entails that the offspring are treated at the litter level and not as individuals. Both evolutions might result in weaning lightweight piglets, which can cause, e.g., growth retardation of the offspring. Hence, the objective of this research was to improve the weaning weight of piglets of the same age by breeding with a highly conformed sire line...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27893278/expected-fitness-gains-of-randomized-search-heuristics-for-the-traveling-salesperson-problem
#5
Samadhi Nallaperuma, Frank Neumann, Dirk Sudholt
Randomized search heuristics are frequently applied to NP-hard combinatorial optimization problems. The runtime analysis of randomized search heuristics has contributed tremendously to their theoretical understanding. Recently, randomized search heuristics have been examined regarding their achievable progress within a fixed time budget. We follow this approach and present a fixed budget analysis for an NP-hard combinatorial optimization problem. We consider the well-known Traveling Salesperson problem (TSP) and analyze the fitness increase that randomized search heuristics are able to achieve within a given fixed time budget...
November 28, 2016: Evolutionary Computation
https://www.readbyqxmd.com/read/27871103/development-of-an-unbiased-validation-protocol-to-assess-the-biofidelity-of-finite-element-head-models-used-in-prediction-of-traumatic-brain-injury
#6
Chiara Giordano, Svein Kleiven
This study describes a method to identify laboratory test procedures and impact response requirements suitable for assessing the biofidelity of finite element head models used in prediction of traumatic brain injury. The selection of the experimental data and the response requirements were result of a critical evaluation based on the accuracy, reproducibility and relevance of the available experimental data. A weighted averaging procedure was chosen in order to consider different contributions from the various test conditions and target measurements based on experimental error...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27859323/no-association-between-frequent-apheresis-donation-and-risk-of-fractures-a-retrospective-cohort-analysis-from-sweden
#7
Katrine Grau, Senthil K Vasan, Klaus Rostgaard, Walter Bialkowski, Rut Norda, Henrik Hjalgrim, Gustaf Edgren
BACKGROUND: Citrate anticoagulation during apheresis induces transient alterations in calcium homeostasis. It is unknown whether the repeated, transient alterations in calcium homeostasis experienced by repeated apheresis donors affects bone turnover to increase fracture risk. Our aim was to investigate the risk of osteoporotic and nonosteoporotic fracture among voluntary, frequent apheresis donors. STUDY DESIGN AND METHODS: All apheresis donors were identified from the Scandinavian Donations and Transfusions database (SCANDAT2), which includes information on over 1...
November 18, 2016: Transfusion
https://www.readbyqxmd.com/read/27857684/spatial-localization-of-sources-in-the-rat-subthalamic-motor-region-using-an-inverse-current-source-density-method
#8
Kees J van Dijk, Marcus L F Janssen, Daphne G M Zwartjes, Yasin Temel, Veerle Visser-Vandewalle, Peter H Veltink, Abdelhamid Benazzouz, Tjitske Heida
Objective: In this study we introduce the use of the current source density (CSD) method as a way to visualize the spatial organization of evoked responses in the rat subthalamic nucleus (STN) at fixed time stamps resulting from motor cortex stimulation. This method offers opportunities to visualize neuronal input and study the relation between the synaptic input and the neural output of neural populations. Approach: Motor cortex evoked local field potentials and unit activity were measured in the subthalamic region, with a 3D measurement grid consisting of 320 measurement points and high spatial resolution...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27809882/comparative-effects-of-nebivolol-and-carvedilol-on-left-ventricular-diastolic-function-in-older-heart-failure-patients-with-preserved-ejection-fraction-study-protocol-for-a-randomized-controlled-trial
#9
Kyungil Park, Tae-Ho Park
BACKGROUND: Heart failure (HF) is a common and disabling condition in older people. Randomized clinical trials and meta-analyses have clearly demonstrated that the long-term use of β-Blockers improves the outcome of patients with HF. However, limited data are available on the treatment of older HF patients with preserved ejection fraction (EF). No study has specifically compared the relative effectiveness of carvedilol and nebivolol in treating HF in older patients with preserved EF...
November 3, 2016: Trials
https://www.readbyqxmd.com/read/27798025/views-of-patients-and-professionals-about-electronic-multicompartment-medication-devices-a-qualitative-study
#10
Jill Hall, Christine Bond, Moira Kinnear, Brian McKinstry
OBJECTIVES: To explore the perceived acceptability, advantages and disadvantages of electronic multicompartment medication devices. DESIGN: Qualitative study using 8 focus groups and 10 individual semistructured interviews. Recordings were transcribed and analysed thematically. Strategies were employed to ensure the findings were credible and trustworthy. PARTICIPANTS AND SETTING: Community pharmacists (n=11), general practitioners (n=9), community nurses (n=12) and social care managers (n=8) were recruited from the National Health Service (NHS) and local authority services...
October 17, 2016: BMJ Open
https://www.readbyqxmd.com/read/27782940/effects-of-obesity-and-leptin-deficiency-on-morphine-pharmacokinetics-in-a-mouse-model
#11
Nicholas M Dalesio, Craig W Hendrix, Douglas Hale McMichael, Carol B Thompson, Carlton K K Lee, Huy Pho, Rafael S Arias, Rachael Rzasa Lynn, Jeffrey Galinkin, Myron Yaster, Robert H Brown, Alan R Schwartz
BACKGROUND: Obesity causes multiorgan dysfunction, specifically metabolic abnormalities in the liver. Obese patients are opioid-sensitive and have high rates of respiratory complications after surgery. Obesity also has been shown to cause resistance to leptin, an adipose-derived hormone that is key in regulating hunger, metabolism, and respiratory stimulation. We hypothesized that obesity and leptin deficiency impair opioid pharmacokinetics (PK) independently of one another. METHODS: Morphine PK were characterized in C57BL/6J wild-type (WT), diet-induced obese (DIO), and leptin-deficient (ob/ob) mice, and in ob/ob mice given leptin-replacement (LR) therapy...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27775651/degree-of-suppression-of-mouse-myoblast-cell-line-c%C3%A2-c12-differentiation-varies-according-to-chondroitin-sulfate-subtype
#12
Katsuhiko Warita, Nana Oshima, Naoko Takeda-Okuda, Jun-Ichi Tamura, Yoshinao Z Hosaka
Chondroitin sulfate (CS), a type of glycosaminoglycan (GAG), is a factor involved in the suppression of myogenic differentiation. CS comprises two repeating sugars and has different subtypes depending on the position and number of bonded sulfate groups. However, the effect of each subtype on myogenic differentiation remains unclear. In this study, we spiked cultures of C₂C12 myoblasts, cells which are capable of undergoing skeletal muscle differentiation, with one of five types of CS (CS-A, -B, -C, -D, or -E) and induced differentiation over a fixed time...
October 21, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27774037/uptake-of-silver-nanoparticles-by-monocytic-thp-1-cells-depends-on-particle-size-and-presence-of-serum-proteins
#13
Katja Kettler, Christina Giannakou, Wim H de Jong, A Jan Hendriks, Petra Krystek
Human health risks by silver nanoparticle (AgNP) exposure are likely to increase due to the increasing number of NP-containing products and demonstrated adverse effects in various cell lines. Unfortunately, results from (toxicity) studies are often based on exposure dose and are often measured only at a fixed time point. NP uptake kinetics and the time-dependent internal cellular concentration are often not considered. Macrophages are the first line of defense against invading foreign agents including NPs. How macrophages deal with the particles is essential for potential toxicity of the NPs...
2016: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/27771115/comparing-strategies-to-synchronize-estrus-before-fixed-time-artificial-insemination-in-primiparous-2-year-old-beef-cows
#14
J M Abel, B E Bishop, J M Thomas, M R Ellersieck, S E Poock, M F Smith, D J Patterson
Two experiments evaluated controlled internal drug release (CIDR)-based protocols to synchronize estrus in primiparous 2-year-old beef cows. In each experiment, treatments were balanced according to body condition score and days postpartum. Experiment 1 compared the 14-day CIDR-PG (14-d) and 7-day CO-Synch + CIDR (7-d) protocols on the basis of estrous response, pregnancy rates after fixed-time artificial insemination (FTAI), and final pregnancy rate. Cows assigned to 14-d (n = 355) received a CIDR insert on Day 0 with removal on Day 14...
September 13, 2016: Theriogenology
https://www.readbyqxmd.com/read/27769851/effects-of-continuous-positive-airway-pressure-on-energy-intake-in-obstructive-sleep-apnea-a-pilot-sham-controlled-study
#15
Ari Shechter, Kyle Kovtun, Marie-Pierre St-Onge
Obesity is among the leading risk factors for obstructive sleep apnea (OSA). A reciprocal relationship between obesity and OSA has been proposed, which may be due to excessive food intake. We conducted a pilot study to test the effects of continuous positive airway pressure (CPAP) on energy intake (EI) in OSA patients using a sham-controlled crossover design. In-laboratory total daily EI was assessed after 2mo of active and sham CPAP. Four men were enrolled (age±SEM: 51.8±2.1y; body mass index: 31.5±1.5kg/m(2))...
October 18, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27765076/interspecific-interactions-between-two-tuta-absoluta-lepidoptera-gelechiidae-larval-parasitoids-with-contrasting-life-histories
#16
V Savino, M G Luna, N G Salas Gervassio, C E Coviella
Interspecific interactions between two larval parasitoids of Tuta absoluta (Meyrick) with partially overlapping host niches were studied: the idiobiont ectoparasitoid Dineulophus phthorimaeae De Santis, and the koinobiont endoparasitoid Pseudapanteles dignus (Muesebeck). T. absoluta is an important pest of tomato crops worldwide, and its management could be improved by understanding the competitive interactions and potential coexistence between these two parasitoids. Firstly, a 15-min fixed time laboratory test evaluated the host-searching ability of adult D...
October 21, 2016: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/27749859/demonstration-of-optical-rogue-waves-using-a-laser-diode-emitting-at-980%C3%A2-%C3%A2-nm-and-a-fiber-bragg-grating
#17
Min Won Lee, Fadwa Baladi, Jean-René Burie, Mauro A Bettiati, Azzedine Boudrioua, Alexis P A Fischer
Rogue waves are observed for the first time, to the best of our knowledge, in a 980 nm laser diode subject to filtered optical feedback via a fiber Bragg grating. By counting the number of rogue waves in a fixed time window, a rogue wave map is established experimentally as a function of both the optical feedback ratio and the laser current. The comparison with low frequency fluctuations (LFFs) reveals that the rogue waves observed in our system are, in fact, LFF jump-ups.
October 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27726060/short-term-dietary-concentrate-supplementation-during-estrus-synchronization-treatment-in-beef-cows-increased-igf-i-serum-concentration-but-did-not-affect-the-reproductive-response
#18
A M Rosales-Torres, Z B López-Cedillo, C G Hernández-Coronado, J V Rosete-Fernández, G D Mendoza, A Guzmán
The objective of this study was to evaluate if short-term dietary concentrate supplementation increased IGF-I serum concentration and resulted in a reproductive response during estrus synchronization treatment in non-lactating beef cows. Thirty non-lactating beef cows (Bos indicus × Bos taurus) were allocated to the same pastureland and fed native tropical grasses as a basal diet. Cows were synchronized using a 7-day CO-Synch plus controlled internal drug release (CIDR) protocol and received fixed time artificial insemination (FTAI)...
October 10, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27720321/continuous-alternating-inhaled-antibiotic-therapy-in-cf-a-single-center-retrospective-analysis
#19
C Van de Kerkhove, P C Goeminne, M Kicinski, T S Nawrot, N Lorent, P Van Bleyenbergh, K De Boeck, L J Dupont
INTRODUCTION: The efficacy of inhaled antibiotics to treat chronic Pseudomonas aeruginosa pulmonary infection in patients with cystic fibrosis (CF) has been well established. Few data are available on the value of continuous alternating inhaled antibiotic therapy (CAIT), a strategy increasingly used in the management of CF. OBJECTIVE: To investigate the effect of CAIT on clinical outcome in adult CF patients treated at the University Hospital Leuven. METHODS: Patients with a documented CF diagnosis who received inhaled antibiotics between March 2010 and January 2015 were retrospectively evaluated...
October 5, 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/27720155/physiological-predictors-of-ovulation-and-pregnancy-risk-in-a-fixed-time-artificial-insemination-program
#20
J S Stevenson
The objective of this study was to determine the relative importance and contribution of several physiological factors as predictors of pregnancy risk in an Ovsynch (GnRH-1 - 7 d - PGF2α - 56 h - GnRH-2 - 16 h - artificial insemination) timed artificial insemination program: (1) age of the corpus luteum (CL; original CL, new CL, or both in response to GnRH-1) and resulting progesterone concentrations as they affected luteolysis, ovulation after GnRH-2, and pregnancy risk; (2) progesterone concentration before GnRH-1 and GnRH-2 on subsequent ovulatory response to GnRH-1 and GnRH-2 as well as pregnancy risk; and (3) a combination of these factors in a multivariable logistic regression model to predict pregnancy risk...
October 5, 2016: Journal of Dairy Science
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