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Uric acid

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https://www.readbyqxmd.com/read/28432997/serum-uric-acid-level-is-linked-to-the-disease-progression-rate-in-male-patients-with-multiple-system-atrophy
#1
Jiro Fukae, Shinsuke Fujioka, Shosaburo Yanamoto, Akio Mori, Takahiro Nomi, Taku Hatano, Kousuke Fukuhara, Shinji Ouma, Nobutaka Hattori, Yoshio Tsuboi
OBJECTIVES: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder that may be caused in part by oxidative stress. Uric acid (UA) protects neurons in neurodegenerative disorders via antioxidative effects. The aim of this study was to investigate the relationship between the serum UA concentration and disease progression in MSA patients. PATIENTS AND METHODS: A total of 53 Japanese MSA patients were enrolled in this study. The disease progression rate was estimated by the rate of global disability scale change per year...
April 3, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28432733/variability-in-hba1c-blood-pressure-lipid-parameters-and-serum-uric-acid-and-risk-of-development-of-chronic-kidney-disease-in-type-2-diabetes
#2
Antonio Ceriello, Salvatore De Cosmo, Maria Chiara Rossi, Giuseppe Lucisano, Stefano Genovese, Roberto Pontremoli, Paola Fioretto, Carlo Giorda, Antonio Pacilli, Francesca Viazzi, Giuseppina Russo, Antonio Nicolucci
AIMS: Variability in HbA1c and blood pressure (BP) is associated with the risk of diabetic kidney disease (DKD). No evidence exists on the role of variability in lipids or serum uric acid (UA), or the interplay between the variability of different parameters, on renal outcomes. MATERIALS AND METHODS: Within the AMD Annals database we identified patients with ≥5 measurements of HbA1c, SBP and DBP, total-, HDL- and LDL- cholesterol, triglycerides, and UA. Patients were followed-up for up to 5 years...
April 21, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28432611/comparison-of-human-erythrocyte-purine-nucleotide-metabolism-and-blood-purine-and-pyrimidine-degradation-product-concentrations-before-and-after-acute-exercise-in-trained-and-sedentary-subjects
#3
Wioleta Dudzinska, M Suska, A Lubkowska, K Jakubowska, M Olszewska, K Safranow, D Chlubek
This study aimed at evaluating the concentration of erythrocyte purine nucleotides (ATP, ADP, AMP, IMP) in trained and sedentary subjects before and after maximal physical exercise together with measuring the activity of purine metabolism enzymes as well as the concentration of purine (hypoxanthine, xanthine, uric acid) and pyrimidine (uridine) degradation products in blood. The study included 15 male elite rowers [mean age 24.3 ± 2.56 years; maximal oxygen uptake (VO2max) 52.8 ± 4.54 mL/kg/min; endurance and strength training 8...
April 21, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28432550/estradiol-mitigates-ischemia-reperfusion-induced-acute-renal-failure-through-nmda-receptor-antagonism-in-rats
#4
Amrit Pal Singh, Nirmal Singh, Preet Mohinder Singh Bedi
In the present study, we investigated possible involvement of N-methyl-D-aspartate receptors (NMDAR) in estradiol mediated protection against ischemia reperfusion (I/R)-induced acute renal failure (ARF) in rats. Bilateral renal ischemia of 40 min followed by reperfusion for 24 h induced ARF in male wistar rats. Quantification of serum creatinine, creatinine clearance (CrCl), blood urea nitrogen (BUN), uric acid, potassium, fractional excretion of sodium (FeNa), and urinary microproteins was done to assess I/R-induced renal damage in rats...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28431608/relationship-between-serum-uric-acid-and-ischemic-stroke-in-a-large-type-2-diabetes-population-in-china-a-cross-sectional-study
#5
Lijun Wang, Wei Hu, Dandan Miao, Qin Zhang, Chuang Wang, Enchun Pan, Ming Wu
OBJECTIVE: To investigate the relationship of serum UA and ischemic stroke in type 2 diabetes patients in China. METHOD: We examined the above relationship using the data of the project "Comprehensive Research on the Prevention and Control of the Diabetes" (CRPCD) study. A total of 19,442 participants were enrolled in the cross-sectional study. The enrolled participants were divided into quintiles of the serum UA levels with cut off values for two age groups (<60 versus ≥60years)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28431065/cha2ds2-vasc-score-and-blood-biomarkers-to-identify-patients-with-atrial-high-rate-episodes-and-paroxysmal-atrial-fibrillation
#6
Paulina Wakula, Benjamin Neumann, Jens Kienemund, Eva Thon-Gutschi, Tatjana Stojakovic, Martin Manninger, Daniel Scherr, Hubert Scharnagl, Martin Kapl, Burkert Pieske, Frank R Heinzel
Aims: Paroxysmal atrial fibrillation (PAF) is often asymptomatic but nonetheless harmful. We evaluated the performance of disease-related blood biomarkers and CHA2DS2-VASc score to discriminate for PAF in patients with continuous rhythm monitoring. Methods and Results: Clinical data and blood samples were obtained from patients with dual-chamber pacemakers selected according to the absence (no_AHRE) or presence of Atrial High-Rate Episodes (AHRE) >6 min in recent device history (case-control approach)...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28429125/low-plasma-homoarginine-concentration-is-associated-with-high-rates-of-all-cause-mortality-in-renal-transplant-recipients
#7
Arslan Arinc Kayacelebi, Isidor Minović, Erik Hanff, Anne-Roos S Frenay, Martin H de Borst, Martin Feelisch, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas
In renal transplant recipients (RTR), we recently found that low urinary excretion of homoarginine (hArg) is associated with mortality and graft failure. However, it is not known whether such prospective associations also hold true for plasma concentrations of hArg. In the present study, we therefore determined plasma concentrations of hArg in the same cohort, i.e. in 687 RTR (functioning graft ≥1 year), and in 140 healthy donors, before and after kidney donation. Plasma hArg concentrations were significantly lower in RTR compared to healthy controls [1...
April 20, 2017: Amino Acids
https://www.readbyqxmd.com/read/28428988/polydatin-attenuates-potassium-oxonate-induced-hyperuricemia-and-kidney-inflammation-by-inhibiting-nf-%C3%AE%C2%BAb-nlrp3-inflammasome-activation-via-the-ampk-sirt1-pathway
#8
Lvyi Chen, Zhou Lan
This study was designed to investigate the effects of polydatin (PLD) on potassium oxonate-induced hyperuricemic rats. Hyperuricemic rats were treated with potassium oxonate (250 mg kg(-1)) intragastrically for 7 days, and polydatin (25, 50 mg kg(-1)) or allopurinol (5 mg kg(-1)) was administered to the rats 1 h after the potassium oxonate exposure. Polydatin administration decreased the levels of uric acid and creatinine in serum and urine, leading to inhibition of pro-inflammatory cytokine production in serum and kidney...
April 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28428699/putative-role-of-cardio-metabolic-risk-among-poorly-controlled-asthmatics-in-south-indian-population
#9
Murugaiyan Sathish Babu, K P Sreesoorya, Surendra K Menon, Subiman Saha, A R Srinivasan, S Arul Vijaya Vani, R Reeta, V Kuzhandai Velu
Mortality and morbidity attributed to asthma remains to be the biggest nightmare worldwide. Hence, the study was aimed to compare the cardio metabolic risk factors as assessed by Body mass index (BMI), waist hip ratio (WHR), serum triacylglycerol and uric acid in well controlled and poorly controlled asthmatics and to correlate these parameters with the severity of asthma. A case control study was conducted on 90 subjects who were segregated into well controlled asthmatics (n = 30) and poorly controlled asthmatics (n = 30) who were diagnosed based on Global initiative for Asthma management guidelines and healthy volunteers (n = 30)...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428698/circadian-periodicity-of-circulating-plasma-lipid-peroxides-uric-acid-and-ascorbic-acid-in-renal-stone-formers
#10
Rajeev Singh Kushwaha, R C Gupta, J P Sharma, Sumita Sharma, Raj Kumar Singh, Germaine Cornelissen
Circadian periodicity of plasma lipid peroxides and serum ascorbic acid and uric acid levels were studied in one hundred renal stone formers (55 women and 45 men; age 20-60 years) and 50 clinically healthy volunteers (21 women and 29 men; age 21-45 years) with diurnal activity from 06:00 to 22:00 and nocturnal rest. A marked circadian variation was demonstrated by population-mean-cosinor for all studied variables in stone formers and healthy subjects. By comparison to the healthy controls, parameter tests indicate that the stone formers had a higher MESOR (±SE) of MDA (2...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428691/relationship-between-xanthine-oxidase-ischemia-modified-albumin-nitric-oxide-with-antioxidants-in-non-pregnants-pre-and-post-delivery-of-normal-pregnants-and-preeclampsia
#11
Vanishree Bambrana, C D Dayanand, Pushpa Kotur
Preeclampsia is a multisystem disorder involves altered homeostasis of oxidants-antioxidants, inflammatory process and endothelial dysfunction. The present study aim was to determine the levels of oxidative stress parameters (malondialdehyde, protein carbonyl, ischemia modified albumin and xanthine oxidase), nutrient antioxidants (vitamin C and vitamin E), enzyme antioxidants (catalase, superoxide dismutase, glutathione peroxidase glutathione reductase), total antioxidant status (TAS) and its association with nitric oxide...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28427449/urolithiasis-analysis-in-a-multiethnic-population-at-a-tertiary-hospital-in-nairobi-kenya
#12
Francis K Wathigo, Alfred Hayombe, Daniel Maina
BACKGROUND: Urolithiasis is a global problem whose incidence is reported to be on the rise across the world. Previously, urolithiasis was reported as being rare among the indigenous African population but recent data suggest otherwise. This study reviewed the demographic and clinical characteristics of patients with urolithiasis seen at the Aga Khan University hospital Nairobi (AKUHN) as well as the chemical composition of the stones and the modalities of therapy used. METHODS: This was a retrospective study which utilized patients' clinical and laboratory records from 2013 to 2014...
April 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28426788/association-between-hemoglobin-glycation-index-with-insulin-resistance-and-carotid-atherosclerosis-in-non-diabetic-individuals
#13
Maria Adelaide Marini, Teresa Vanessa Fiorentino, Elena Succurro, Elisabetta Pedace, Francesco Andreozzi, Angela Sciacqua, Francesco Perticone, Giorgio Sesti
Hemoglobin glycation index (HGI), defined as the difference between the observed HbA1c value and the value of HbA1c predicted from plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with micro- and macro-vascular complications in subjects with type 2 diabetes. To investigate the pathophysiological abnormalities responsible for the increased cardiovascular risk of patients with higher HGI, we evaluated the association of HGI with cardio-metabolic characteristics in nondiabetic offspring of type 2 diabetic individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28425242/evaluation-of-serum-uric-acid-levels-in-psoriasis-vulgaris
#14
Emrah Yilmaz, Emine Tamer, Ferda Artüz, Seray Külcü Çakmak, Fürüzan Köktürk
BACKGROUND/AIM: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425024/lesinurad-a-review-in-hyperuricaemia-of-gout
#15
Emma D Deeks
Lesinurad (Zurampic(®)) is an oral selective inhibitor of the URAT1 and OAT4 uric acid (UA) transporters of the kidney, via which it inhibits UA reabsorption and thus increases renal UA excretion and lowers serum UA (sUA) levels. Lesinurad 200 mg once daily is indicated for use in combination with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in adults with gout who have not achieved target sUA levels with an XOI alone. Approval was based on three 12-month phase 3 trials that evaluated lesinurad in combination with allopurinol in adults with gout inadequately responsive to allopurinol (CLEAR 1 and 2) and in combination with febuxostat in adults with tophaceous gout (CRYSTAL)...
April 19, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28423036/metabolic-syndrome-serum-uric-acid-and-renal-risk-in-patients-with-t2d
#16
Francesca Viazzi, Pamela Piscitelli, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Paola Fioretto, Salvatore De Cosmo, Roberto Pontremoli
BACKGROUND AND AIMS: Metabolic Syndrome (Mets) and increased serum uric acid (SUA), are well known renal risk predictors and often coexist in patients with type 2 diabetes (T2D). Whether they independently contribute to the onset of CKD is at present unclear. METHODS AND RESULTS: Within the AMD Annals database we identified patients with T2D and normal renal function and urine albumin excretion at baseline and regular follow-up visits during a 4-year period. Blood pressure, BMI, HDL, triglycerides, and SUA were available in 14,267 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28422036/physicochemical-factors-of-the-urine-of-children-with-hypercalciuria
#17
Mercedes Ubetagoyena-Arrieta, Jorge Martínez Sáenz de Jubera, María Nieves Corera-Casty, Eduardo González Pérez-Yarza, Irati García-Albizua
OBJECTIVE: Hypercalciuria is a common lithogenic risk factor. The aim of this study was, first, to study the characteristics of urine biochemical factors of children with hypercalciuria (HC) and compare them with those of children without hypercalciuria. Second, to analyze the differences between children with HC and lithiasis (HCL) and children with HC and no lithiasis (HCNL). METHODS: The sample was composed by 111 cases with HC, divided into 2 groups: HCNL group, consisting of 93 cases with no personal history of kidney stones, and HCL group, 18 cases with personal history of kidney stones...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28421120/in-vitro-and-in-vivo-studies-on-quercus-acuta-thunb-fagaceae-extract-active-constituents-serum-uric-acid-suppression-and-xanthine-oxidase-inhibitory-activity
#18
In-Soo Yoon, Dae-Hun Park, Min-Suk Bae, Deuk-Sil Oh, Nan-Hui Kwon, Jung-Eun Kim, Chul-Yung Choi, Seung-Sik Cho
Quercus acuta Thunb. (Fagaceae) (QA) is cultivated as a dietary and ornamental plant in China, Japan, South Korea, and Taiwan. It has been widely used as the main ingredient of acorn tofu, a traditional food in China and South Korea. The aim of this study was to determine in vitro and in vivo xanthine oxidase (XO) inhibitory and antihyperuricemic activities of an ethyl acetate extract of QA leaf (QALE) and identify its active phytochemicals using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC) systems...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28420204/fructose-intake-serum-uric-acid-and-cardiometabolic-disorders-a-critical-review
#19
REVIEW
Cristiana Caliceti, Donato Calabria, Aldo Roda, Arrigo F G Cicero
There is a direct relationship between fructose intake and serum levels of uric acid (UA), which is the final product of purine metabolism. Recent preclinical and clinical evidence suggests that chronic hyperuricemia is an independent risk factor for hypertension, metabolic syndrome, and cardiovascular disease. It is probably also an independent risk factor for chronic kidney disease, Type 2 diabetes, and cognitive decline. These relationships have been observed for high serum UA levels (>5.5 mg/dL in women and >6 mg/dL in men), but also for normal to high serum UA levels (5-6 mg/dL)...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28420196/probe-sensor-using-nanostructured-multi-walled-carbon-nanotube-yarn-for-selective-and-sensitive-detection-of-dopamine
#20
Wed Al-Graiti, Zhilian Yue, Javad Foroughi, Xu-Feng Huang, Gordon Wallace, Ray Baughman, Jun Chen
The demands for electrochemical sensor materials with high strength and durability in physiological conditions continue to grow and novel approaches are being enabled by the advent of new electromaterials and novel fabrication technologies. Herein, we demonstrate a probe-style electrochemical sensor using highly flexible and conductive multi-walled carbon nanotubes (MWNT) yarns. The MWNT yarn-based sensors can be fabricated onto micro Pt-wire with a controlled diameter varying from 100 to 300 µm, and then further modified with Nafion via a dip-coating approach...
April 18, 2017: Sensors
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