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Catherine Prouvot, François Golfier, Jérôme Massardier, Benoit You, Jean-Pierre Lotz, Sophie Patrier, Mojgan Devouassoux, Anne-Marie Schott, Touria Hajri, Pierre-Adrien Bolze
OBJECTIVE: The objective of this study was to evaluate the characteristics and outcomes of patients treated for gestational trophoblastic neoplasia (GTN) with second-line 5-day dactinomycin after failed first-line 8-day methotrexate. METHODS: From 1999 to 2017, patients with methotrexate resistant GTN treated with second line dactinomycin were identified at the French Trophoblastic Disease Reference Center. Using univariate and multivariate analysis, we identified significant predictive factors of second line dactinomycin failure...
April 6, 2018: International Journal of Gynecological Cancer
Austin R Horn, Charles Weijer, Jeremy Grimshaw, Jamie Brehaut, Dean Fergusson, Cory E Goldstein, Monica Taljaard
The SUPPORT trial highlights ethical challenges raised by comparative effectiveness randomized controlled trials (ceRCTs) involving one or more usual care interventions. Debate about the SUPPORT trial has focused on whether study interventions posed "reasonably foreseeable risks" to enrolled infants and, thereby, reflects a preoccupation with U.S. regulations. As ceRCTs are conducted globally, our analysis of the SUPPORT trial is grounded in internationally accepted ethical principles. We argue that the central ethical issue raised by the SUPPORT trial is the following: should the SUPPORT trial interventions be conceptualized as practice, or research? The answer to this question has important implications for "downstream" ethical requirements-including whether the usual care interventions in ceRCTs require research ethics committee review, undergo harm-benefit analysis, and are included in informed consent documents-and it is antecedent to the development of ethical guidance for ceRCTs...
2018: Kennedy Institute of Ethics Journal
Veronica Mary Maluwa, Elizabeth Gwaza, Betty Sakala, Esnath Kapito, Ruth Mwale, Clara Haruzivishe, Ellen Chirwa
BACKGROUND: Nurses are expected to provide comprehensive, holistic and ethically accepted care according to their code of ethics and practice. However, in Malawi, this is not always the case. This article analyses moral competence concept using the Walker and Avant's strategy of concept analysis. OBJECTIVE: The aim of this article is to analyse moral competence concept in relation to nursing practice and determine defining attributes, antecedents and consequences of moral competence in nursing practice...
January 1, 2018: Nursing Ethics
Andrea B Goldschmidt, Kathryn E Smith, Ross D Crosby, Hope K Boyd, Elizabeth Dougherty, Scott G Engel, Alissa Haedt-Matt
OBJECTIVES: Contextual factors related to maladaptive eating behavior in youth with overweight/obesity are poorly understood. This pilot study sought to elucidate immediate internal and external cues related to perceptions of overeating and loss of control (LOC) over eating in a heterogeneous sample of children and adolescents with overweight/obesity assessed in their natural environments. METHOD: Community-based youth [N = 40; 55% female (n = 22)], aged 8-14 y (M age = 11...
April 6, 2018: International Journal of Eating Disorders
Bertrand Lefrère, Alain Stepanian, Nathalie Itzhar-Baïkian, Perrine Charles, Arezki Hadj-Ali, Bérangère Joly, Martine Alhenc-Gelas, Ludovic Drouet, Agnès Veyradier, Virginie Siguret
Congenital disorders of glycosylation (CDG) are rare inborn diseases of glycan component of N-glycosylated proteins. We report here the case of a 28-year-old patient with CDG syndrome type Ia, who presented with a deep venous thrombosis in the left suro-popliteal vein with no known triggers or antecedents. The patient was treated with rivaroxaban for six months. Blood tests performed after discontinuing anticoagulant treatment showed multiple abnormalities affecting the proteins involved in haemostasis (both coagulation factors and inhibitors), i...
April 1, 2018: Annales de Biologie Clinique
Francesco Brigo, Veronica Tavernelli, Raffaele Nardone, Eugen Trinka
Idiopathic (genetic) generalized epilepsies (IGEs) are age-related epileptic syndromes with typical age onset in childhood or adolescence. We report a patient with de novo late-onset absence status epilepticus (ASE) occurring at the age of 64 years, with clinical and EEG features suggestive of late-onset IGE. We also discuss the relationship between de novo late-onset ASE and late-onset IGE, and provide a comprehensive and critical review of the available literature on late-onset (i.e. onset ≥60 years) IGE...
April 5, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
J Luo, H Weng, J C Morris, C Xiong
BACKGROUND: Clinical trials of investigational drugs for Alzheimer disease (AD) increasingly focus on the prodromal (symptomatic) stage of the illness and now its preclinical (asymptomatic) stage. Sensitive and specific cognitive and functional endpoints are needed to track subtle cognitive and functional changes in the early and preclinical stages to minimize sample sizes in these trials. OBJECTIVES: To identify informative items in a standard clinical assessment protocol and a psychometric battery that are predictive of onset of dementia symptom...
2018: Journal of Prevention of Alzheimer's Disease
Sofija Pajic, Magdalena Ulceluse, Gábor Kismihók, Stefan T Mol, Deanne N den Hartog
The goal of the current study was to investigate the relationships among psychological resources, career barriers, and job search self-efficacy in a sample of post-2014 Syrian refugees. Participants included 330 refugees in Greece and the Netherlands. Data were obtained using paper-based surveys, with all measures translated into Arabic. Drawing from career construction theory (Savickas, 2005), we hypothesized that adaptive readiness, operationalized in terms of psychological capital, would be positively related to job search self-efficacy through career adaptability...
April 2018: Journal of Vocational Behavior
Eva-Stina Edholm, Maureen Banach, Kun Hyoe Rhoo, Martin S Pavelka, Jacques Robert
The amphibian Xenopus laevis is to date the only species outside of mammals where a MHC class I-like (MHC-like) restricted innate-like (i) T cell subset (iVα6 T cells) reminiscent of CD1d-restricted iNKT cells has been identified and functionally characterized. This provides an attractive in vivo model to study the biological analogies and differences between mammalian iT cells and the evolutionarily antecedent Xenopus iT cell defense system. Here, we report the identification of a unique iT cell subset (Vα45-Jα1...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
Tareq Al-Shargabi, Daniel Reich, R B Govindan, Somya Shankar, Marina Metzler, Caitlin Cristante, Robert McCarter, Anthony D Sandler, Mariam Said, Adre du Plessis
BACKGROUND:  Necrotizing enterocolitis (NEC) is a complication of prematurity with a high mortality rate. Currently, there are no reliable biomarkers capable of identifying infants at risk for developing NEC. We sought to determine the autonomic nervous system antecedents of NEC in premature infants, using heart rate variability (HRV). MATERIALS AND METHODS:  HRV was quantified by retrieving archived electrocardiogram (EKG) data from 30 premature infants from 4 days prior, through 4 days after, the clinical NEC diagnosis...
April 2, 2018: American Journal of Perinatology
Federico Cipriano, Lycio U Dessoti, Alfredo José Rodrigues, Walter Vilella de Andrade Vicente, Fernando Chahud, Paulo Roberto B Evora
Lung cancers may extend along or grow through the pulmonary veins to invade or lie within the left atrium (LA). A 62-year-old man, previously healthy, presented with 1-month ventilatory-independent right hemithorax back pain, dry cough and large effort dyspnea. He also referred weight loss of 12 kg in 10 months and denied hemoptysis. As antecedents, he smoked for 40 years and moderate daily alcoholism. On physical examination, the patient was in good general condition, hydrated and regular respiration at rest [blood pressure (BP) =120/80 mmHg; heart rate (HR) =90 bpm; respiratory rate (RR) =16 rpm]...
January 2018: Journal of Thoracic Disease
Tammy M Brady, Amalia Stefani-Glücksberg, Giacomo D Simonetti
Over the last several decades, many seminal longitudinal cohort studies have clearly shown that the antecedents to adult disease have their origins in childhood. Hypertension (HTN), which has become increasingly prevalent in childhood, represents one of the most important risk factors for cardiovascular diseases (CVD) such as heart disease and stroke. With the risk of adult HTN much greater when HTN is manifest in childhood, the future burden of CVD worldwide is therefore concerning. In an effort to slow the current trajectory, professional societies have called for more rigorous, evidence-based guideline development to aid primary care providers and subspecialists in improving recognition, diagnosis, evaluation, and treatment of pediatric HTN...
March 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Jennifer A Cotter, Linda Szymanski, Catherine Karimov, Lara Boghossian, Ashley Margol, Girish Dhall, Benita Tamrazi, G Isaac Varaprasathan, David M Parham, Alexander R Judkins, Jaclyn A Biegel
Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome caused by germline alterations in the tumor suppressor gene TP53. LFS is associated with numerous malignancies including astrocytoma. Sanger sequencing and chromosomal microarray studies of blood and tumor tissue from a 4-year-old boy with glioblastoma demonstrated a germline TP53 mutation with loss of heterozygosity for the short arm of chromosome 17 as the second inactivating event in the tumor. There was no family history of LFS, but the child's mother had recently died from metastatic choriocarcinoma after antecedent normal term delivery of a then 6-month-old daughter...
March 26, 2018: Cold Spring Harbor Molecular Case Studies
Dana Maria Bichescu-Burian, Benjamin Grieb, Tilman Steinert, Carmen Uhlmann, Jürgen Steyer
This protocol offers a detailed description of a psychophysiological experiment using script-driven trauma-related imagery and standardized clinical instruments within a comparative design assessing physiological and psychopathological features of individuals with BPD. This method aims at studying the psychological and physiological effects of trauma-related dissociation. Since the psychodiagnostic classification of trauma-related disorders relies on the observation of evolutionarily determined responses to life-threat, an integrated assessment paradigm for the study of reactions to traumatic memories proposes a very appropriate methodological approach...
March 8, 2018: Journal of Visualized Experiments: JoVE
Raeann G LeBlanc, Cynthia S Jacelon
PURPOSE: The aim of this study was to clarify the concept of self-care among older people living with chronic health conditions. This concept clarification will assist nurses in addressing self-care among older people through research, policy and practice in offering an expanded conceptual model. BACKGROUND: Several policy influences over the past decade directly relate to the increased importance and economic necessity to require self-directed care for older people living with chronic health conditions to maintain their care at home in the community...
March 24, 2018: International Journal of Older People Nursing
Jashin J Wu, Aditya A Joshi, Shivani P Reddy, Michael Batech, Alexander Egeberg, Ole Ahlehoff, Nehal N Mehta
BACKGROUND: Psoriasis is a systemic chronic inflammatory condition associated with increased risk of cardiovascular disease. Data demonstrating that decreased skin inflammation reduces cardiovascular events in psoriasis patients may be generalizable to other chronic inflammatory states with heightened cardiovascular risk. OBJECTIVE: To determine whether tumor necrosis factor inhibitor (TNFi) therapy is associated with decreased major adverse cardiovascular events (MACE) in psoriasis patients...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Elodie Collinge, Sandrine Loron, Marie-Virginie Larcher, Mohamed Elhamri, Maël Heiblig, Alexandre Deloire, Sophie Ducastelle, Hélène Labussière, Fiorenza Barraco, Eric Wattel, Gilles Salles, Etienne Paubelle, Xavier Thomas
INTRODUCTION: Secondary acute myeloid leukemia (sAML) remains a therapeutic challenge. In elderly patients with AML, it is unclear whether sAML displays an inferior outcome compared with de novo AML. PATIENTS AND METHODS: We studied AML with an antecedent of hematologic disease, treatment-related AML, or AML occurring concurrently to another malignancy in a single-center cohort of patients aged 70 and older with AML. The study included 169 patients who were compared with a cohort of patients with de novo AML, without any prior history of malignant disorders, seen during the same period of time...
March 2, 2018: Clinical Lymphoma, Myeloma & Leukemia
Grant A Pignatiello, Richard J Martin, Ronald L Hickman
Decision fatigue is an applicable concept to healthcare psychology. Due to a lack of conceptual clarity, we present a concept analysis of decision fatigue. A search of the term "decision fatigue" was conducted across seven research databases, which yielded 17 relevant articles. The authors identified three antecedent themes (decisional, self-regulatory, and situational) and three attributional themes (behavioral, cognitive, and physiological) of decision fatigue. However, the extant literature failed to adequately describe consequences of decision fatigue...
March 1, 2018: Journal of Health Psychology
Bert N Uchino, Ryan Trettevik, Robert G Kent de Grey, Sierra Cronan, Jasara Hogan, Brian R W Baucom
OBJECTIVE: Social support and social integration have been linked to lower rates of morbidity and mortality. However, the biological mechanisms responsible for such links need greater attention to advance theory and unique intervention opportunities. The main aim of this article was to conduct a meta-analytic review of the association between social support-social integration and inflammatory cytokines (e.g., interleukin-6, C-reactive protein) and test several proposed moderators from prior qualitative reviews...
March 22, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Sara R Berzenski
Efforts to differentiate between the developmental sequelae of childhood emotional abuse and childhood emotional neglect are critical to both research and practice efforts. As an oft-identified mechanism of the effects of child maltreatment on later adjustment, emotion dysregulation represents a key potential pathway. The present study explored a higher order factor model of specific emotion regulation skills, and the extent to which these skill sets would indicate distinct developmental pathways from unique emotional maltreatment experiences to multidomain adjustment...
March 22, 2018: Development and Psychopathology
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