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https://www.readbyqxmd.com/read/28437755/an-in-vitro-study-of-cartilage-meniscus-tribology-to-understand-the-changes-caused-by-a-meniscus-implant
#1
Sara Ehsani Majd, Aditya Iman Rizqy, Hans J Kaper, Tannin A Schmidt, Roel Kuijer, Prashant K Sharma
Active lifestyles increase the risk of meniscal injury. A permanent meniscus implant of polycarbonate urethane (PCU) is a promising treatment to postpone/prevent total knee arthroplasty. Study of the changes in articular cartilage tribology in the presence of PCU is essential in developing the optimum meniscus implant. Therefore, a cartilage-meniscus reciprocating, sliding model was developed in vitro, mimicking the stance and swing phases of the gait cycle. The meniscus was further replaced with PCU and surface-modified PCUs (with C18 chains, mono-functional polydimethylsiloxane groups and mono-functional polytetrafluoroethylene groups) to study the changes...
April 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28437736/murine-diet-induced-obesity-remodels-cardiac-and-liver-mitochondrial-phospholipid-acyl-chains-with-differential-effects-on-respiratory-enzyme-activity
#2
E Madison Sullivan, Amy Fix, Miranda J Crouch, Genevieve C Sparagna, Tonya N Zeczycki, David A Brown, Saame Raza Shaikh
Cardiac phospholipids, notably cardiolipin, undergo acyl chain remodeling and/or loss of content in aging and cardiovascular diseases, which is postulated to mechanistically impair mitochondrial function. Less is known about how diet-induced obesity influences cardiac phospholipid acyl chain composition and thus mitochondrial responses. Here we first tested if a high fat diet remodeled murine cardiac mitochondrial phospholipid acyl chain composition and consequently disrupted membrane packing, supercomplex formation and respiratory enzyme activity...
April 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28437552/bcr-abl1-transcript-types-showed-distinct-laboratory-characteristics-in-patients-with-chronic-myeloid-leukemia
#3
A P Vasconcelos, I F Azevedo, F C B C Melo, W B Neves, A C A C Azevedo, R A M Melo
In chronic myeloid leukemia (CML) two main types of messenger RNA (e14a2 and e13a2) can be produced by BCR-ABL1 gene rearrangement. Due to conflicting results, the clinical value of these transcripts remains controversial. The aim of this study was to identify associations of e14a2 and e13a2 transcripts with laboratory variables and also the response to treatment. This study included 203 adult patients with CML treated with Imatinib as first-line drug in a reference hematology center in Northeast Brazil. Clinical and laboratory data were obtained after informed consent...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28437551/association-of-interleukin-6-gene-polymorphisms-and-circulating-levels-with-keloid-scars-in-a-chinese-han-population
#4
X J Zhu, W Z Li, H Li, C Q Fu, J Liu
The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay (ELISA). Results indicated that when the IL-6 -572 CC homozygote genotype was used as the reference group, the GG genotype was found to be associated with a significantly increased risk of KS (GG vs CC: OR = 2...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28437540/characterization-of-gene-expression-phenotype-in-amyotrophic-lateral-sclerosis-monocytes
#5
Weihua Zhao, David R Beers, Kristopher G Hooten, Douglas H Sieglaff, Aijun Zhang, Shanker Kalyana-Sundaram, Christopher M Traini, Wendy S Halsey, Ashley M Hughes, Ganesh M Sathe, George P Livi, Guo-Huang Fan, Stanley H Appel
Importance: Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by selective loss of upper and lower motor neurons. Patients with ALS have persistent peripheral and central inflammatory responses including abnormally functioning T cells and activated microglia. However, much less is known about the inflammatory gene profile of circulating innate immune monocytes in these patients. Objective: To characterize the transcriptomics of peripheral monocytes in patients with ALS...
April 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28437479/conformational-dynamics-of-bacterial-trigger-factor-in-apo-and-ribosome-bound-states
#6
Mehmet Tarik Can, Zeynep Kurkcuoglu, Gokce Ezeroglu, Arzu Uyar, Ozge Kurkcuoglu, Pemra Doruker
The chaperone trigger factor (TF) binds to the ribosome exit tunnel and helps cotranslational folding of nascent chains (NC) in bacterial cells and chloroplasts. In this study, we aim to investigate the functional dynamics of fully-atomistic apo TF and its complex with 50S. As TF accomodates a high percentage of charged residues on its surface, the effect of ionic strength on TF dynamics is assessed here by performing five independent molecular dynamics (MD) simulations (total of 1.3 micro-second duration) at 29 mM and 150 mM ionic strengths...
2017: PloS One
https://www.readbyqxmd.com/read/28437455/effect-of-a-probiotic-beverage-consumption-enterococcus-faecium-crl-183-and-bifidobacterium-longum-atcc-15707-in-rats-with-chemically-induced-colitis
#7
Larissa Sbaglia Celiberto, Raquel Bedani, Naiara Naiana Dejani, Alexandra Ivo de Medeiros, José Antonio Sampaio Zuanon, Luis Carlos Spolidorio, Maria Angela Tallarico Adorno, Maria Bernadete Amâncio Varesche, Fábio Carrilho Galvão, Sandro Roberto Valentini, Graciela Font de Valdez, Elizeu Antonio Rossi, Daniela Cardoso Umbelino Cavallini
BACKGROUND: Some probiotic strains have the potential to assist in relieving the symptoms of inflammatory bowel disease. The impact of daily ingestion of a soy-based product fermented by Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with the addition of Bifidobacterium longum ATCC 15707 on chemically induced colitis has been investigated thereof within a period of 30 days. METHODS: Colitis was induced by dextran sulfate sodium. The animals were randomly assigned into five groups: Group C: negative control; Group CL: positive control; Group CLF: DSS with the fermented product; Group CLP: DSS with the non-fermented product (placebo); Group CLS: DSS with sulfasalazine...
2017: PloS One
https://www.readbyqxmd.com/read/28437448/expression-profiling-of-chrysanthemum-crassum-under-salinity-stress-and-the-initiation-of-morphological-changes
#8
Zhiyong Guan, Yitong Feng, Aiping Song, Xiaomeng Shi, Yachao Mao, Sumei Chen, Jiafu Jiang, Lian Ding, Fadi Chen
Chrysanthemum crassum is a decaploid species of Chrysanthemum with high stress tolerance that allows survival under salinity stress while maintaining a relatively ideal growth rate. We previously recorded morphological changes after salt treatment, such as the expansion of leaf cells. To explore the underlying salinity tolerance mechanisms, we used an Illumina platform and obtained three sequencing libraries from samples collected after 0 h, 12 h and 24 h of salt treatment. Following de novo assembly, 154,944 transcripts were generated, and 97,833 (63...
2017: PloS One
https://www.readbyqxmd.com/read/28437439/landscape-and-environmental-influences-on-mycobacterium-ulcerans-distribution-among-aquatic-sites-in-ghana
#9
Shannon M Pileggi, Heather Jordan, Julie A Clennon, Ellen Whitney, M Eric Benbow, Richard Merritt, Mollie McIntosh, Ryan Kimbirauskas, Pamela Small, Daniel Boakye, Charles Quaye, Jiaguo Qi, Lindsay Campbell, Jenni Gronseth, Edwin Ampadu, William Opare, Lance A Waller
Buruli ulcer, caused by Mycobacterium ulcerans, is highly endemic in West Africa. While the mode of transmission is unknown, many studies associate Buruli ulcer with different types of water exposure. We present results from the largest study to date to test for M. ulcerans in aquatic sites and identify environmental attributes associated with its presence. Environmental samples from 98 aquatic sites in the Greater Accra, Ashanti, and Volta regions of Ghana were tested for the presence of M. ulcerans DNA by polymerase chain reaction...
2017: PloS One
https://www.readbyqxmd.com/read/28437282/inhibition-of-mid-chain-hetes-protects-against-angiotensin-ii-induced-cardiac-hypertrophy
#10
Samya Elkhatali, Zaid H Maayah, Ahmed A El-Sherbeni, Osama H Elshenawy, Ghada Abdelhamid, Sherif M Shoieb, Ayman O S El-Kadi
Recent data demonstrated the role of CYP1B1 in cardiovascular disease. It was, therefore, necessary to examine whether the inhibition of CYP1B1 and hence inhibiting the formation of its metabolites, using 2,4,3',5'-tetramethoxystilbene (TMS), would have a cardioprotective effect against angiotensin II (Ang II)-induced cardiac hypertrophy. For this purpose, male Sprague-Dawley rats were treated with Ang II with or without TMS (300 μg/kg every 3day3 i.p). Thereafter, cardiac hypertrophy and the formation of mid-chain HETEs and AA were assessed...
April 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28437231/capsular-polysaccharide-types-and-virulence-related-traits-of-epidemic-kpc-producing-klebsiella-pneumoniae-isolates-in-a-chinese-university-hospital
#11
Yang Liu, Pan-Pan Liu, Lian-Hui Wang, Dan-Dan Wei, La-Gen Wan, Wei Zhang
Klebsiella pneumoniae is an important human pathogen associated with a variety of diseases and the prevalence of blaKPC carrying K. pneumoniae (KPC-Kp) is rapidly increasing. Capsule is an important virulence factor in K. pneumoniae. In this study, we determined to first systematically characterize capsular polysaccharide (CPS) and virulence traits in KPC-Kp strains. A total of 56 KPC-Kp isolates were recovered from clinical samples in a Chinese hospital, which were assigned to clonal lineages by multilocus sequence typing (MLST)...
February 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28437230/high-diversity-of-antimicrobial-resistance-genes-class-1-integrons-and-genotypes-of-multidrug-resistant-escherichia-coli-in-beef-carcasses
#12
Chih-Ming Chen, Se-Chin Ke, Chia-Ru Li, Ying-Chen Wu, Ter-Hsin Chen, Chih-Ho Lai, Xin-Xia Wu, Lii-Tzu Wu
Multidrug-resistant Escherichia coli can contaminate food meat during processing and cause human infection. Phenotypic and genotypic characterization of the antimicrobial resistance were conducted for 45 multidrug-resistant E. coli isolates from 208 samples of beef carcasses. The mechanisms of resistance were evaluated using polymerase chain reaction and sequencing methods, and the clonal relationship among isolates was evaluated using multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE)...
February 23, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28437200/effects-of-dietary-macronutrient-composition-on-fndc5-and-irisin-in-mice-skeletal-muscle
#13
Simone Moreira de Macêdo, Deborah de Farias Lelis, Keila Lopes Mendes, Carlos Alberto de Carvalho Fraga, Igor V Brandi, Jonh David Feltenberger, Lucyana Conceição Farias, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Sérgio Henrique de Sousa Santos
BACKGROUND: Fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity. We aimed to investigate the association between muscle Irisin expression and dietary quality. METHODS: Twenty-eight female mice were divided into four groups and fed the following experimental diets for 60 days: standard diet (SD), high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD)...
February 23, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28437198/branched-chain-amino-acids-are-associated-with-insulin-resistance-independent-of-leptin-and-adiponectin-in-subjects-with-varying-degrees-of-glucose-tolerance
#14
Margery A Connelly, Justyna Wolak-Dinsmore, Robin P F Dullaart
BACKGROUND: Branched chain amino acids (BCAA) may be involved in the pathogenesis of insulin resistance and are associated with type 2 diabetes mellitus (T2DM) development. Adipokines such as leptin and adiponectin influence insulin resistance and reflect adipocyte dysfunction. We examined the extent to which the association of BCAA with insulin resistance is attributable to altered leptin and adiponectin levels in individuals with varying degrees of glucose tolerance. METHODS: BCAA were measured by nuclear magnetic resonance, whereas leptin and adiponectin were measured by immunoassay, in subjects with normal fasting glucose (n = 30), impaired fasting glucose (n = 25), and T2DM (n = 15)...
February 21, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28437195/home-health-chains-and-practice-patterns-evidence-of-2008-medicare-reimbursement-revision
#15
Sean Shenghsiu Huang, Hyunjee Kim
Home health agencies (HHAs) are known to exploit the Medicare reimbursement schedule by targeting a specific number of therapy visits. These targeting behaviors cause unnecessary medical spending. The Centers for Medicare & Medicaid Services estimates that during fiscal year 2015, Medicare made more than $10 billion in improper payments to HHAs. Better understanding of heterogeneous gaming behaviors among HHAs can inform policy makers to more effectively oversee the home health care industry. This article aims to study how home health chains adjust and adopt new targeting behaviors as compared to independent agencies under the new reimbursement schedule...
February 23, 2017: Population Health Management
https://www.readbyqxmd.com/read/28437165/survey-for-listeria-monocytogenes-in-and-on-ready-to-eat-foods-from-retail-establishments-in-the-united-states-2010-through-2013-assessing-potential-changes-of-pathogen-prevalence-and-levels-in-a-decade
#16
John B Luchansky, Yuhuan Chen, Anna C S Porto-Fett, Régis Pouillot, Bradley A Shoyer, Rachel Johnson-DeRycke, Denise R Eblen, Karin Hoelzer, William K Shaw, Jane M van Doren, Michelle Catlin, Jeehyun Lee, Rohan Tikekar, Daniel Gallagher, James A Lindsay, Sherri Dennis
A multiyear interagency Listeria monocytogenes Market Basket Survey was undertaken for selected refrigerated ready-to-eat foods purchased at retail in four FoodNet sites in the United States. Food samples from 16 food categories in six broad groups (seafood, produce, dairy, meat, eggs, and combination foods) were collected weekly at large national chain supermarkets and independent grocery stores in California, Maryland, Connecticut, and Georgia for 100 weeks between December 2010 and March 2013. Of the 27,389 total samples, 116 samples tested positive by the BAX PCR system for L...
April 24, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28437019/extending-unique-1d-borate-chains-to-3d-framework-by-introducing-metallic-nodes
#17
Guo-Yu Yang, Qi Wei, Shi-Jia Sun, Jie Zhang
Two novel alkali/alkaline-earth borates, Ba6[B6O9 (OH)6]2(H3BO3) (1) and Li7MAlB12O24 (M = Ba, Sr, Ca) (2a-c), with 1- and 3-D structures have been hydrothermally made and characterized. 1 features a rarely 1-D anionic chain built by hexaborate clusters of B6O11(OH)6 made of six BO4/ BO2(OH)2 tetrahedra. The anionic chains are embedded in the channels of Ba6-based wheel cluster open-framework. On the basis of the structural analyses of 1, by incorporating the rational Al atoms as the linkers and tuning the reaction conditions, the anhydrous borates 2a-c have been success-fully obtained, showing novel 3-D aluminoborates (ABOs) constructed from B6O14-based cluster chains and AlO6 octa-hedra...
April 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28437018/polar-side-chains-enhance-processability-electrical-conductivity-and-thermal-stability-of-a-molecularly-p-doped-polythiophene
#18
Renee Kroon, David Kiefer, Dominik Stegerer, Liyang Yu, Michael Sommer, Christian Müller
Molecular doping of organic semiconductors is critical for optimizing a range of optoelectronic devices such as field-effect transistors, solar cells, and thermoelectric generators. However, many dopant:polymer pairs suffer from poor solubility in common organic solvents, which leads to a suboptimal solid-state nanostructure and hence low electrical conductivity. A further drawback is the poor thermal stability through sublimation of the dopant. The use of oligo ethylene glycol side chains is demonstrated to significantly improve the processability of the conjugated polymer p(g4 2T-T)-a polythiophene-in polar aprotic solvents, which facilitates coprocessing of dopant:polymer pairs from the same solution at room temperature...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28436914/a-time-variant-log-linear-learning-approach-to-the-set-k-cover-problem-in-wireless-sensor-networks
#19
Changhao Sun
Toward the global optimality of the SET K-COVER problem in wireless sensor networks, we view each sensor node as a rational player and propose a time variant log-linear learning algorithm (TVLLA) that relies on local information only. By defining the local utility as the normalized area covered by one node alone, we formulate the problem as a spatial potential game. The resulting optimal Nash equilibria correspond to the optimal partition. Such equilibria are obtained by designing a time varying parameter β that approaches infinity with time...
April 19, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28436865/video-anomaly-detection-with-compact-feature-sets-for-online-performance
#20
Roberto Leyva, Victor Sanchez, Chang-Tsun Li
Over the past decade, video anomaly detection has been explored with remarkable results. However, research on methodologies suitable for online performance is still very limited. In this paper, we present an online framework for video anomaly detection. The key aspect of our framework is a compact set of highly descriptive features, which is extracted from a novel cell structure that helps to define support regions in a coarse-to-fine fashion. Based on the scene's activity, only a limited number of support regions are processed, thus limiting the size of the feature set...
April 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
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