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https://www.readbyqxmd.com/read/29055276/nonadiabatic-dynamics-simulation-of-photoisomerization-mechanism-of-the-second-stablest-isomer-of-n-salicilydenemethylfurylamine
#1
Aihua Gao, Jianpeng Li, Dehua Wang, Xiaoguang Ma, Meishan Wang
The photoisomerization processes of the second stablest isomer in the aromatic Schiff base, N-salicilydenemethylfurylamine, in the gas phase have been studied by static electronic structure calculations and surface-hopping dynamics simulations based on the Zhu-Nakamura theory. Various stable structures are obtained in the optimization because of different orientations of methyl-furyl part with respect to the salicylaldimine part and different orientations of hydroxy group with respect to the benzene ring. Upon photoexcitation into the first excited state, bond isomerization in the salicylaldimine part is completely suppressed until the strong excited-state hydrogen bond is broken...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055249/peptide-nucleic-acid-as-a-selective-recognition-element-for-electrochemical-determination-of-hg-2
#2
Agnieszka Bala, Łukasz Górski
A novel electrochemical PNA-based biosensor for the determination of Hg(2+) is described. The receptor layer, containing single strands of polythymine PNA (peptide nucleic acid), was formed at the surface of gold electrode. Due to the presence of thymine bases and peptide bonds, an interaction between Hg(2+) ion and receptor layer occurs. The influence of chain modification - PNA vs. DNA - and type of redox marker - anionic AQMS-Na (sodium salt of anthraquinone-2-sulfonic acid) and Fe(II/III) (potassium ferri/ferrocyanide) or cationic MB (methylene blue) and RuHex (hexaammineruthenium(III) chloride) - were studied...
October 12, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29055238/patterns-produced-by-dried-droplets-of-protein-binary-mixtures-suspended-in-water
#3
Yojana J P Carreón, Jorge González-Gutiérrez, M I Pérez-Camacho, Hilda Mercado-Uribe
Patterns formed by the evaporation of a drop containing biological molecules have provided meaningful information about certain pathologies. In this context, several works propose the study of protein solutions as a model to understand the formation of deposits of biological fluids. Generally, dry droplets of proteins in a saline solution create complex aggregates. Here, we present an experimental study on the formation of patterns produced by the evaporation of droplet suspensions containing a protein binary mixture...
October 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29055186/designed-inhibitors-with-hetero-linkers-for-gastric-proton-pump-h-k-atpase-steered-molecular-dynamics-and-metadynamics-studies
#4
Kalyanashis Jana, Tusar Bandyopadhyay, Bishwajit Ganguly
Acid suppressant SCH28080 and its derivatives reversibly reduce acid secretion activity of the H(+),K(+)-ATPase in a K(+) competitive manner. The results on homologation of the SCH28080 by varying the linker chain length suggested the improvement in efficacy. However, the pharmacokinetic studies reveal that the hydrophobic nature of the CH2 linker units may not help it to function as a better acid suppressant. We have exploited the role of linker unit to enhance the efficacy of such reversible acid suppressant drug molecules using hetero linker, i...
October 12, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29055099/regulation-of-glycosaminoglycan-biogenesis-is-critical-for-sensitive-period-dependent-vocal-ontogeny
#5
Caitlin P Mencio, Vy My Tran, Maritza V Quintero, Mamoru Koketsu, Franz Goller, Balagurunathan Kuberan
In the brain, the extracellular matrix (ECM) plays a central role during neural development and thus modulates critical-period regulated behavioral ontogeny. The major components of the ECM are glycosaminoglycans (GAGs) including chondroitin sulfate (CS). However, the specific roles of GAGs in behavioral development are largely unknown. It has been shown that xylosides affect the biological functions of GAGs through modulating GAG biosynthesis. Particularly, xylosides affect GAG biosynthesis through priming of GAG chains (priming activity), competing with endogenous core proteins that carry GAG initiation sites (decoy activity), or both...
October 21, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29055069/evidence-of-evolutionary-optimization-of-fatty-acid-length-and-unsaturation
#6
I Galván
The lipid composition of cell membranes exerts a crucial influence on cell physiology. Indeed, one double bond triggers membrane fluidity, essential for cell functionality, but additional double bonds increase the susceptibilty to peroxidation, which produces reactive compounds that impair the viability of cells. It has therefore been suggested, but never tested in an extensive comparative context, that the composition of membrane fatty acids has been optimized during evolution. A similar prediction has been made for fatty acid chain length, on which susceptibility to peroxidation also depends...
October 20, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29055027/pharmacological-and-gene-regulation-properties-point-to-the-slhak5-k-transporter-as-a-system-for-high-affinity-cs-uptake-in-tomato-plants
#7
Reyes Rodenas, Manuel Nieves-Cordones, Rosa María Rivero, Vicente Martinez, Francisco Rubio
Potassium (K(+) ) and Cesium (Cs(+) ) are chemically similar but while K(+) is an essential nutrient, Cs(+) can be toxic for living organisms, plants included. Two different situations could lead to problems derived from the presence of Cs(+) in agricultural systems: (1) presence of Cs(+) at high concentrations that could produce toxic effects on plants and (2) presence of micromolar concentrations of radiocesium, which can be accumulated in the plant and affect animal and human health through the food chain...
October 21, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29055017/new-generation-nanomedicines-constructed-from-self-assembling-small-molecule-prodrugs-alleviate-cancer-drug-toxicity
#8
Hangxiang Wang, Zhongjie Lu, Lijiang Wang, Tingting Guo, Jiaping Wu, Jianqin Wan, Liqian Zhou, Hui Li, Zhen Li, Donghai Jiang, Penghong Song, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng
The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing a drug molecule and using sequential drug-induced nanoassembly to fabricate supramolecular nanomedicines (SNM). Using cabazitaxel (CTX) as a target agent, we established that individual synthetic prodrugs tethered with polyunsaturated fatty acids were capable of recapitulating self-assembly behavior independent of exogenous excipients...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29055007/the-structure-of-the-mhc-class-i-molecule-of-bony-fishes-provides-insights-into-the-conserved-nature-of-the-antigen-presenting-system
#9
Zhaosan Chen, Nianzhi Zhang, Jianxun Qi, Rong Chen, Johannes M Dijkstra, Xiaoying Li, Zhenbao Wang, Junya Wang, Yanan Wu, Chun Xia
MHC molecules evolved with the descent of jawed fishes some 350-400 million years ago. However, very little is known about the structural features of primitive MHC molecules. To gain insight into these features, we focused on the MHC class I Ctid-UAA of the evolutionarily distant grass carp (Ctenopharyngodon idella). The Ctid-UAA H chain and β2-microglobulin (Ctid-β2m) were refolded in vitro in the presence of peptides from viruses that infect carp. The resulting peptide-Ctid-UAA (p/Ctid-UAA) structures revealed the classical MHC class I topology with structural variations...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29054962/expanded-alleles-of-the-fmr1-gene-are-related-to-unexplained-recurrent-miscarriages
#10
Xin-Hua Wang, Xiao-Hua Song, Tong Li, Xing-Hua Diao, Qing-Chun Li, Xiang-Hui Zhang, Yan-Lin Wang, Xiao-Hui Deng
Up to 50% of recurrent miscarriage cases in women occur without an underlying etiology. In the current prospective case-control study, we determined the impact of CGG trinucleotide expansions of the FMR1 gene in 49 women with unexplained recurrent miscarriages. Case group consisted of women with 2 or more unexplained consecutive miscarriages. Blood samples were obtained and checked for the presence of expanded alleles of the FMR1 gene using polymerase chain reaction. Patients harboring the expanded allele, with a threshold set to 40 repeats, were further evaluated by sequencing...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054925/platelet-mitochondrial-dysfunction-and-the-correlation-with-human-diseases
#11
REVIEW
Li Wang, Qiang Wu, Zhijia Fan, Rufeng Xie, Zhicheng Wang, Yuan Lu
The platelet is considered as an accessible and valuable tool to study mitochondrial function, owing to its greater content of fully functional mitochondria compared with other metabolically active organelles. Different lines of studies have demonstrated that mitochondria in platelets have function far more than thrombogenesis regulation, and beyond hemostasis, platelet mitochondrial dysfunction has also been used for studying mitochondrial-related diseases. In this review, the interplay between platelet mitochondrial dysfunction and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined...
October 20, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29054919/comparison-of-elevated-phosphorylated-neurofilament-heavy-chains-in-serum-and-cerebrospinal-fluid-of-patients-with-amyotrophic-lateral-sclerosis
#12
Maxim De Schaepdryver, Andreas Jeromin, Benjamin Gille, Kristl G Claeys, Victor Herbst, Britta Brix, Philip Van Damme, Koen Poesen
OBJECTIVE: Phosphorylated neurofilament heavy chain (pNfH) levels are elevated in cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). Instead of CSF, we explored blood as an alternative source to measure pNfH in patients with ALS. METHODS: In this single centre retrospective study, 85 patients with ALS, 215 disease controls (DC) and 31 ALS mimics were included. Individual serum pNfH concentrations were correlated with concentrations in CSF and with several clinical parameters...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29054876/the-canonical-biotin-synthesis-enzyme-8-amino-7-oxononanoate-synthase-biof-utilizes-different-acyl-chain-donors-in-bacillus-subtilis-and-escherichia-coli
#13
Miglena Manandhar, John E Cronan
BioF (8-amino-7-oxononanoate synthase) is a strictly conserved enzyme that catalyzes the first step in assembly of the fused heterocyclic rings of biotin. The BioF acyl chain donor has long been thought to be pimeloyl-CoA. Indeed, in vitro the Escherichia coli and Bacillus sphaericus enzymes have been shown to condense pimeloyl-CoA with L-alanine in a pyridoxal 5' -phosphate-dependent reaction with concomitant CoA release and decarboxylation of L-alanine. However, recent in vivo studies of E. coli and Bacillus subtilis suggested that the BioF proteins of the two bacteria could have different specificities for pimelate thioesters in that E...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054875/a-novel-steroid-coenzyme-a-ligase-from-novosphingobium-sp-strain-chol11-is-essential-for-an-alternative-degradation-pathway-for-bile-salts
#14
Onur Yücel, Johannes Holert, Kevin Christopher Ludwig, Sven Thierbach, Bodo Philipp
Bile salts such as cholate are steroid compounds with a C5 carboxylic side chain and occur ubiquitously in vertebrates. Upon their excretion into soils and waters bile salts can serve as growth substrates for diverse bacteria. Novosphingobium sp. strain Chol11 degrades 7-hydroxy bile salts via 3-keto-7-deoxy-Δ(4,6) metabolites by dehydration of the 7-hydroxyl group catalyzed by the 7α-hydroxysteroid dehydratase Hsh2. This reaction has not been observed in the well-studied 9-10-seco degradation pathway used by other steroid-degrading bacteria indicating that strain Chol11 uses an alternative pathway...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054800/aptamer-affinity-ligands-in-protein-chromatography
#15
REVIEW
Gérald Perret, Egisto Boschetti
The present review deals with the place of single chain oligonucleotide ligands (aptamers) in affinity chromatography applied to proteins. Aptamers are not the only affinity ligands available but they represent an emerging and highly promising route that advantageously competes with antibodies in immunopurification processes. A historical background of affinity chromatography from the beginning of the discipline to the most recent outcomes is first presented. Then the focus is centered on aptamers which represent the last step so far to the long quest for affinity ligands associating very high specificity, availability and strong stability against most harsh cleaning agents required in chromatography...
October 17, 2017: Biochimie
https://www.readbyqxmd.com/read/29054765/characterization-of-germline-mutations-in-familial-lung-cancer-from-the-chinese-population
#16
Madiha Kanwal, Xiao-Jie Ding, Zhans-Han Ma, Lian-Wei Li, Ping Wang, Ying Chen, Yun-Chao Huang, Yi Cao
Compared with numerous studies of somatic mutations using sporadic lung cancer, the research into germline mutations using familial lung cancer (FLC) is limited. In the present study, we used FLC samples obtained from the Chinese population in highly air-polluted regions to screen for novel germline mutations in lung cancer. Through a whole genome sequencing (WGS) analysis of the nine subjects (four lung cancer patients and five normal family members of FLC), we obtained a whole genome dataset of DNA alterations in FLC samples...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054763/association-of-genetic-variants-of-hemostatic-genes-with-myocardial-infarction-in-egyptian-patients
#17
Amal Ahmed Abd El-Fatah, Nermin Abdel Hamid Sadik, Heba Sedrak, Ahmed Battah, Mai Nabil
Hemostatic genes polymorphisms are well known to be associated with venous thrombosis, but their association with arterial thrombosis especially myocardial infarction (MI) remains to be clarified. We investigated the role of three hemostatic gene polymorphisms, prothrombin G20210A, factor XIII (FXIII) Val34Leu (G/T), and fibrinogen-β-455G/A and their coexistence in Egyptian patients with MI. The possible correlation of these polymorphisms with plasma fibrinogen level was also evaluated. The study included 120 patients with MI and 60 healthy volunteers...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054761/differential-expression-levels-of-plasma-microrna-in-hashimoto-s-disease
#18
Lijuan Zhao, Xin Zhou, Xia Shan, Lian-Wen Qi, Tongshan Wang, Jun Zhu, Danxia Zhu, Zebo Huang, Lan Zhang, Huo Zhang, Yin Yin, Zhiyan Wang, Wei Zhu, Wenfang Cheng, Lin Jiang
BACKGROUND: The altered expression of circulating miRNAs has been discovered in many autoimmune diseases (ADs). With rare existing research, it is still unclear in Hashimoto's thyroiditis (HT). We detected plasma miRNA expression of HT patients in this three-stage designed study. METHODS: Differently expressed miRNAs (4 HT pools vs. 1 normal control pool) were identified using quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel (miRCURY-Ready-to-Use- PCR-Human- panel-I+II-V1...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054758/cystic-fibrosis-transmembrane-regulator-haplotypes-in-households-of-patients-with-cystic-fibrosis
#19
Daniela Tenório Furgeri, Fernando Augusto Lima Marson, Cyntia Arivabeni Araújo Correia, José Dirceu Ribeiro, Carmen Sílvia Bertuzzo
INTRODUCTION: Nearly 2000 mutations in the cystic fibrosis transmembrane regulator (CFTR) gene have been reported. The F508del mutation occurs in approximately 50-65% of patients with cystic fibrosis (CF). However, molecular diagnosis is not always possible. Therefore, silent polymorphisms can be used to label the mutant allele in households of patients with CF. OBJECTIVE: To verify the haplotypes of four polymorphisms at the CFTR locus in households of patients with CF for pre-fertilization, pre-implantation, and prenatal indirect mutation diagnosis to provide better genetic counseling for families and patients with CF and to associate the genotypes/haplotypes with the F508del mutation screening...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054755/association-of-polymorphic-variants-in-il1b-gene-with-secretion-of-il-1%C3%AE-protein-and-inflammatory-markers-in-north-indian-rheumatoid-arthritis-patients
#20
Mohd Jahid, Rehan-Ul-Haq, Diwesh Chawla, Rajnish Avasthi, Rafat Sultana Ahmed
The proinflammatory cytokine interleukin-1beta (IL-1β) is a key mediator of inflammation which affects cell proliferation and differentiation. IL-1β is considered to contribute to the pathophysiology of rheumatoid arthritis (RA). Polymorphisms in cytokine genes are highly influenced by ethnicity. Hence, in this study polymorphism of the IL1B-511(C/T) within promoter region was analyzed by using polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP) in 187 RA patients and 214 controls...
October 17, 2017: Gene
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