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https://www.readbyqxmd.com/read/28406522/inhibition-of-polyglutamine-aggregation-by-similar-huntingtin-n-terminal-sequences-prospective-molecules-for-preclinical-evaluation-in-huntington-s-disease
#1
Gunasekhar Burra, Ashwani Kumar Thakur
The mutant huntingtin protein (mHtt) fragments with expanded polyglutamine sequence forms microscopically visible aggregates in neurons, a hallmark of Huntington's disease (HD). The aggregation process and aggregates are possible targets of therapeutic intervention in HD. Due to lack of treatment and cure, the patients die within 15-20 years after the disease onset. Therefore, discovering therapeutic molecules that may either inhibit the aggregation mechanism or downregulate the toxic effects of mhtt are highly needed...
April 12, 2017: Biopolymers
https://www.readbyqxmd.com/read/28365524/pancreas-and-liver-uptake-of-new-radiolabeled-incretins-glp-1-and-exendin-4-in-models-of-diet-induced-and-diet-restricted-obesity
#2
Daniele Seo, Bluma Linkowski Faintuch, Erica Aparecida de Oliveira, Joel Faintuch
INTRODUCTION: Radiolabeled GLP-1 and its analog Exendin-4, have been employed in diabetes and insulinoma. No protocol in conventional Diet-Induced Obesity (DIO), and Diet-Restricted Obesity (DRO), has been identified. Aiming to assess pancreatic beta cell uptake in DIO and DRO, a protocol was designed. METHODS: GLP-1-βAla-HYNIC and HYNIC-βAla-Exendin-4 were labeled with technetium-99m. Four Swiss mouse models were adopted: Controls (C), Alloxan Diabetes Controls (ADC), DIO and DRO...
March 18, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28298676/dehulling-and-microwave-pretreatment-effects-on-the-physicochemical-composition-and-antioxidant-capacity-of-virgin-rapeseed-oil
#3
Agnieszka Rękas, Aleksander Siger, Małgorzata Wroniak, Iwona Ścibisz, Dorota Derewiaka, Andrzej Anders
The effect of microwave heating (800 W) of whole and dehulled rapeseeds for 2 to 8 min was investigated in order to evaluate the impact of dehulling in conjunction with microwaving on the nutritional value, antioxidant activity and physicochemical properties of virgin rapeseed oil. Control oil produced from dehulled seeds (DRO) had higher amounts of bioactive compounds, such as tocochromanols and phytosterols, lower content of pigments, and higher content of primary and secondary oxidation products compared to oil pressed from whole seeds (WRO)...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28192671/electron-deficient-dihydroindaceno-dithiophene-regioisomers-for-n-type-organic-field-effect-transistors
#4
Jean-David Peltier, Benoît Heinrich, Bertrand Donnio, Joëlle Rault-Berthelot, Emmanuel Jacques, Cyril Poriel
In this work, we wish to report the first member of a new family of organic semiconductors constructed on a meta dihydroindacenodithiophene core, that is, 2,2'-(2,8-dihexyl-4,6-dihydro-s-indaceno[1,2-b:7,6-b']dithiophene-4,6-diylidene)dimalononitrile (called meta-IDT(═C(CN)2)2). The properties of this molecule were studied in detail through a structure-properties relationship study with its regioisomer, that is, 2,2'-(2,7-dihexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene-4,9-diylidene)dimalononitrile (para-IDT(═C(CN)2)2) (see isomer structures in blue in Chart 2)...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28185463/-lymphoedema-following-regional-lymph-node-surgery-for-breast-cancer
#5
P Vrtělová, O Coufal, V Fait, L Gabrielová, O Zapletal
BACKGROUND: The treatment of breast cancer is based on the multimodal principle and surgery of regional lymph nodes is an inseparable part of this. Indication criteria are changing constantly folowing advances in other modalities. It is necessary to consider not only the diagnostic or therapeutic benefit but also to take into account adverse effects. Previous studies have demonstrated that axillary dissection (ALND) is burdened by a high frequency of chronic lymphoedema of the arm or chest wall; however, a considerable percentage of patients may also suffer from lymphoedema after sentinel lymph node biopsy (SLNB)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27740509/distributed-robust-optimization-in-networked-system
#6
Shengnan Wang, Chunguang Li
In this paper, we consider a distributed robust optimization (DRO) problem, where multiple agents in a networked system cooperatively minimize a global convex objective function with respect to a global variable under the global constraints. The objective function can be represented by a sum of local objective functions. The global constraints contain some uncertain parameters which are partially known, and can be characterized by some inequality constraints. After problem transformation, we adopt the Lagrangian primal-dual method to solve this problem...
October 11, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27739580/establishing-motion-control-in-children-with-autism-and-intellectual-disability-applications-for-anatomical-and-functional-mri
#7
Alison D Cox, Javier Virues-Ortega, Flavia Julio, Toby L Martin
Excessive motion makes magnetic resonance imaging (MRI) extremely challenging among children with autism spectrum disorder (ASD). The medical risks of sedation establish the need for behavioral interventions to promote motion control among children with ASD undergoing MRI scans. We present a series of experiments aimed at establishing both tolerance of the MRI environment and a level of motion control that would be compatible with a successful MRI. During Study 1, we evaluated the effects of prompting and contingent reinforcement on compliance with a sequence of successive approximations to an MRI using a mock MRI...
October 14, 2016: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/27734468/comparing-fixed-amount-and-progressive-amount-dro-schedules-for-tic-suppression-in-youth-with-chronic-tic-disorders
#8
Matthew R Capriotti, Jennifer E Turkel, Rachel A Johnson, Flint M Espil, Douglas W Woods
Chronic tic disorders (CTDs) involve motor and/or vocal tics that often cause substantial distress and impairment. Differential reinforcement of other behavior (DRO) schedules of reinforcement produce robust, but incomplete, reductions in tic frequency in youth with CTDs; however, a more robust reduction may be needed to affect durable clinical change. Standard, fixed-amount DRO schedules have not commonly yielded such reductions, so we evaluated a novel, progressive-amount DRO schedule, based on its ability to facilitate sustained abstinence from functionally similar behaviors...
October 13, 2016: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/27707594/the-positive-impact-of-radiologic-imaging-on-high-stage-cutaneous-squamous-cell-carcinoma-management
#9
Emily Stamell Ruiz, Pritesh S Karia, Frederick C Morgan, Chrysalyne D Schmults
BACKGROUND: There is limited evidence on the utility of radiologic imaging for prognostic staging of cutaneous squamous cell carcinoma (CSCC). OBJECTIVE: Review utilization of radiologic imaging of high-stage CSCCs to evaluate whether imaging impacted management and outcomes. METHODS: Tumors classified as Brigham and Women's Hospital (BWH) tumor (T) stage T2B or T3 over a 13-year period were reviewed to identify whether imaging was performed and whether results affected treatment...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27626237/life-cycle-of-petroleum-biodegradation-metabolite-plumes-and-implications-for-risk-management-at-fuel-release-sites
#10
Dawn A Zemo, Kirk T O'Reilly, Rachel E Mohler, Renae I Magaw, Catalina Espino Devine, Sungwoo Ahn, Asheesh K Tiwary
This paper summarizes the results of a 5-year research study of the nature and toxicity of petroleum biodegradation metabolites in groundwater at fuel release sites that are quantified as diesel-range "Total Petroleum Hydrocarbons" (TPH; aka TPHd, DRO, etc.), unless a silica gel cleanup (SGC) step is used on the sample extract prior to the TPH analysis. This issue is important for site risk management in regulatory jurisdictions that use TPH as a metric; the presence of these metabolites may preclude site closure even if all other factors can be considered "low-risk...
September 14, 2016: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/27622130/differential-reinforcement-of-other-behaviour-for-the-reduction-of-severe-nail-biting
#11
Louise Heffernan, Danielle Lyons
The effects of differential reinforcement of other behaviour (DRO) were investigated for the treatment of severe self-injurious nail biting in an individual diagnosed with autism. A functional behaviour assessment (FBA) identified that the behaviour was maintained by automatic reinforcement. Following the implementation of the DRO procedure and access to reinforcing stimuli that were believed to provide similar sensory feedback to that of the self-injurious nail biting, the results indicate that the nail biting was successfully reduced and maintained at near zero levels...
September 2016: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/27505124/helping-the-helpers-assisting-staff-and-volunteer-workers-before-during-and-after-disaster-relief-operations
#12
REVIEW
Randal P Quevillon, Brandon L Gray, Sara E Erickson, Elvira D Gonzalez, Gerard A Jacobs
Self-care strategies and system supports employed in preparation for, during, and after disaster relief operations (DROs) are crucial to relief worker well-being and the overall effectiveness of relief efforts. Relief organizations and management must structure DROs in a manner that promotes self-care and workers must implement proper self-care strategies. Proper self-care before, during, and after a DRO can reduce negative reactions to stressful emergency work and promote growth, mastery, and self-efficacy after the experience...
December 2016: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27497836/progesterone-attenuates-impulsive-action-in-a-go-no-go-task-for-sucrose-pellets-in-female-and-male-rats
#13
Natashia Swalve, John R Smethells, Marilyn E Carroll
Impulsivity, or a tendency to act without anticipation of future consequences, is associated with drug abuse. Impulsivity is typically separated into two main measures, impulsive action and impulsive choice. Given the association of impulsivity and drug abuse, treatments that reduce impulsivity have been proposed as an effective method for countering drug addiction. Progesterone has emerged as a promising treatment, as it is associated with decreased addiction-related behaviors and impulsive action. The goal of the present study was to determine the effects of progesterone (PRO) on impulsive action for food: a Go/No-Go task...
September 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27429473/determination-of-bendamustine-in-human-plasma-and-urine-by-lc-fl-methods-application-in-a-drug-monitoring
#14
Alina Plenis, Agnieszka Frolow, Natalia Rekowska, Ilona Olędzka, Piotr Kowalski, Ewa Bień, Małgorzata Anna Krawczyk, Elżbieta Adamkiewicz-Drożynska, Tomasz Bączek
Simple and sensitive liquid chromatography (LC) methods with fluorescence (FL) detection for the determination of bendamustine (BM) in human plasma and urine were developed and validated. The procedure of BM extraction from a plasma sample involved solid-phase extraction with a C18 SPE column, while liquid-liquid extraction with dichloromethane was applied for a urine sample. In both methods, cinoxacin was used as the internal standard. Chromatographic separations were performed on a Synergi Max-RP column, while FL detector was set at the excitation wavelength of 328 nm and the emission wavelength of 420 nm...
2016: Chromatographia
https://www.readbyqxmd.com/read/27401679/mmp2-mmp9-and-timp2-polymorphisms-affect-sperm-parameters-but-not-fertility-in-polish-males
#15
M Kurzawski, M Kaczmarek, M Kłysz, D Malinowski, A Kazienko, R Kurzawa, M Droździk
Proper function of the blood-testis barrier is pivotal to spermatogenesis. Synchronised action of matrix metalloproteinases (MMP) and their inhibitors (TIMP) is mandatory to maintain dynamic balance of the barrier. Therefore, the association of functional genetic variants of MMP-2, MMP-9 and TIMP-2 and male infertility was studied. A total of 416 infertile males and 421 healthy subjects were genotyped for 7 SNPs within MMP2, MMP9 and TIMP2 genes, along with the assessment of semen parameters (concentration, motility and morphology of spermatozoa)...
July 12, 2016: Andrologia
https://www.readbyqxmd.com/read/27398817/evaluating-a-humane-alternative-to-the-bark-collar-automated-differential-reinforcement-of-not-barking-in-a-home-alone-setting
#16
Alexandra Protopopova, Dmitri Kisten, Clive Wynne
The aim of this study was to develop a humane alternative to the traditional remote devices that deliver punishers contingent on home-alone dog barking. Specifically, we evaluated the use of remote delivery of food contingent on intervals of not barking during the pet owner's absence. In Experiment 1, 5 dogs with a history of home-alone nuisance barking were recruited. Using an ABAB reversal design, we demonstrated that contingent remote delivery of food decreased home-alone barking for 3 of the dogs. In Experiment 2, we demonstrated that it is possible to thin the differential-reinforcement-of-other-behavior (DRO) schedule gradually, resulting in a potentially more acceptable treatment...
December 2016: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/27374606/diagnosis-clinical-course-and-1-year-outcome-in-patients-hospitalized-for-heart-failure-with-preserved-ejection-fraction-from-the-polish-cohort-of-the-european-society-of-cardiology-heart-failure-long-term-registry
#17
Agnieszka Kapłon-Cieślicka, Agata Tymińska, Michał Peller, Paweł Balsam, Krzysztof Ozierański, Michalina Galas, Michał Marchel, Maria G Crespo-Leiro, Aldo Pietro Maggioni, Jarosław Drożdż, Krzysztof J Filipiak, Grzegorz Opolski
Compared with heart failure (HF) with reduced ejection fraction (HF-REF), the diagnosis of HF with preserved EF (HF-PEF) is more challenging. The aim of the study was to assess the prevalence of HF-PEF among patients hospitalized for HF, to evaluate the pertinence of HF-PEF diagnosis and to compare HF-PEF and HF-REF patients with respect to outcomes. The analysis included 661 Polish patients hospitalized for HF, selected from the European Society of Cardiology (ESC)-HF Long-Term Registry. Patients with an EF of ≥50% were included in the HF-PEF group and patients with an EF of <50% - in the HF-REF group...
August 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27355963/novel-solid-self-nanoemulsifying-drug-delivery-system-s-snedds-for-oral-delivery-of-olmesartan-medoxomil-design-formulation-pharmacokinetic-and-bioavailability-evaluation
#18
Ali Nasr, Ahmed Gardouh, Mamdouh Ghorab
The main purpose of this study was to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of Olmesartan (OLM) for enhancement of its solubility and dissolution rate. In this study, liquid SNEDDS containing Olmesartan was formulated and further developed into a solid form by the spray drying technique using Aerosil 200 as a solid carrier. Based on the preliminary screening of different unloaded SNEDDS formulae, eight formulae of OLM loaded SNEEDS were prepared using Capryol 90, Cremophor RH40 and Transcutol HP as oil, surfactant and cosurfactant, respectively...
June 27, 2016: Pharmaceutics
https://www.readbyqxmd.com/read/27355375/comprehensive-characterization-of-the-electronic-structure-of-u-4-in-uranium-iv-phosphate-chloride
#19
Anna Bronova, Thomas Droß, Robert Glaum, Heiko Lueken, Manfred Speldrich, Werner Urland
Emerald-green single crystals of U(PO4)Cl were grown by chemical vapor transport in a temperature gradient (1000 → 900 °C). The crystal structure of U(PO4)Cl (Cmcm, Z = 4, a = 5.2289(7) Å, b = 11.709(2) Å, c = 6.9991(8) Å) consists of a three-dimensional network of [PO4] tetrahedra and bicapped octahedral [U(IV)O6Cl2] groups. Polarized absorption spectra measured for two perpendicular polarization directions show a large number of well-resolved electronic transitions. These transitions can be fully assigned on the basis of a detailed ligand-field treatment within the framework of the angular overlap model...
July 18, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27334342/analysis-of-absorption-and-spreading-of-moisturizer-on-the-microscopic-region-of-the-skin-surface-with-near-infrared-imaging
#20
H Arimoto, M Yanai, M Egawa
BACKGROUND/PURPOSE: Near-infrared (NIR) light with high water absorption enables us to visualize the water content distribution appeared in the superficial skin layer. The light penetration depth with the wavelength of 1920 nm is almost 100 μm from the skin surface. Thus, the water distribution in the stratum corneum can be effectively imaged by detecting the wavelength band around 1920 nm. The aim of this article was to measure the time-lapse behavior of the tiny droplet of the moisturizer spreading on the skin surface by imaging in 1920 nm wavelength band for investigating the correlation with the traditional index of the skin condition such as the water content and transepidermal water loss (TEWL)...
November 2016: Skin Research and Technology
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