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https://www.readbyqxmd.com/read/28314191/robust-detection-and-segmentation-of-cell-nuclei-in-biomedical-images-based-on-a-computational-topology-framework
#1
Rodrigo Rojas-Moraleda, Wei Xiong, Niels Halama, Katja Breitkopf-Heinlein, Steven Dooley, Luis Salinas, Dieter W Heermann, Nektarios A Valous
The segmentation of cell nuclei is an important step towards the automated analysis of histological images. The presence of a large number of nuclei in whole-slide images necessitates methods that are computationally tractable in addition to being effective. In this work, a method is developed for the robust segmentation of cell nuclei in histological images based on the principles of persistent homology. More specifically, an abstract simplicial homology approach for image segmentation is established. Essentially, the approach deals with the persistence of disconnected sets in the image, thus identifying salient regions that express patterns of persistence...
March 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28302095/perceptions-of-community-based-field-workers-on-the-effect-of-a-longitudinal-biomedical-research-project-on-their-sustainable-livelihoods
#2
Christabelle S Moyo, Joseph Francis, Pascal O Bessong
BACKGROUND: Researchers involved in biomedical community-based projects rarely seek the perspectives of community fieldworkers, who are the 'foot soldiers' in such projects. Understanding the effect of biomedical research on community-based field workers could identify benefits and shortfalls that may be crucial to the success of community-based studies. The present study explored the perceptions of community-based field workers on the effect of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project" (MAL-ED) South Africa on their tangible and intangible capital which together comprise sustainable livelihoods...
March 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28301702/space-for-the-prisoner-s-point-of-view
#3
Laura Haupt
The lead article in this issue discusses a potentially free metaphorical space-that of decision-making-within the confines, tangible and intangible, of life in jail or prison. By interviewing prisoner-participants from six clinical studies, Paul Christopher and colleagues sought to find out how these men and women would answer open-ended questions about their decision to enroll in the research. What the interviewers heard was that none saw themselves as having been inappropriately pressured to do so. In fact, a significant percentage of the prisoners described being dissuaded from participating in the studies...
March 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28299562/gay-and-lesbian-sounding-auditory-cues-elicit-stereotyping-and-discrimination
#4
Fabio Fasoli, Anne Maass, Maria Paola Paladino, Simone Sulpizio
The growing body of literature on the recognition of sexual orientation from voice ("auditory gaydar") is silent on the cognitive and social consequences of having a gay-/lesbian- versus heterosexual-sounding voice. We investigated this issue in four studies (overall N = 276), conducted in Italian language, in which heterosexual listeners were exposed to single-sentence voice samples of gay/lesbian and heterosexual speakers. In all four studies, listeners were found to make gender-typical inferences about traits and preferences of heterosexual speakers, but gender-atypical inferences about those of gay or lesbian speakers...
March 15, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28293228/prevention-and-control-strategies-to-counter-zika-epidemic
#5
REVIEW
Irfan A Rather, Sanjay Kumar, Vivek K Bajpai, Jeongheui Lim, Yong-Ha Park
ZIKA virus (ZIKA) has now become a global phenomenon. Since 2007, evidence of ZIKA transmission has been reported over 72 countries and territories. The transmission of ZIKA has made World Health Organization to categorize the situation under the ambit of a health emergency. This situation is serious because there appears to be a highly tangible link between infection during pregnancy and the occurrence of microcephaly and Guillain-Barré syndrome. In the context of this emergency situation, this review article intends to discuss the prevention and control strategies such as avoiding travel to infected area, being careful from mosquito bites, take precautions to reduce the risk of sexual transmission, and seek medical care for any acute illness with rash or fever...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28283121/health-care-expenditures-associated-with-pollution-exploratory-methods-and-findings
#6
Alexander S Preker, Olusoji O Adeyi, Marisa Gil Lapetra, Diane-Charlotte Simon, Eric Keuffel
BACKGROUND: The research done for this paper is part of the background analysis undertaken to support the work of the Global Commission on Pollution, Health and Development, an initiative of The Lancet, the Global Alliance on Health and Pollution, and the Icahn School of Medicine at Mount Sinai. The paper expands on areas where the current literature has gaps in knowledge related to the health care cost of pollution. OBJECTIVES: This study aims to generate an initial estimate of total tangible health care expenditure attributable to man-made pollution affecting air, soil and water...
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28281790/the-exchange-of-social-support-on-online-bariatric-surgery-discussion-forums-a-mixed-methods-content-analysis
#7
Molly E Atwood, Aliza Friedman, Brad A Meisner, Stephanie E Cassin
Bariatric surgery patients often experience physical and psychosocial stressors, and difficulty adjusting to significant lifestyle changes. As a result, social support groups that provide patients with support, coping skills, and nutritional information are valuable components of bariatric care. Support group attendance at bariatric centers is associated with greater post-surgery weight loss; however, several barriers hinder attendance at in-person support groups (e.g., travel distance to bariatric centers)...
March 10, 2017: Health Communication
https://www.readbyqxmd.com/read/28277568/neurodevelopmental-perspectives-on-wnt-signaling-in-psychiatry
#8
REVIEW
Kimberly A Mulligan, Benjamin N R Cheyette
Mounting evidence indicates that Wnt signaling is relevant to pathophysiology of diverse mental illnesses including schizophrenia, bipolar disorder, and autism spectrum disorder. In the 35 years since Wnt ligands were first described, animal studies have richly explored how downstream Wnt signaling pathways affect an array of neurodevelopmental processes and how their disruption can lead to both neurological and behavioral phenotypes. Recently, human induced pluripotent stem cell (hiPSC) models have begun to contribute to this literature while pushing it in increasingly translational directions...
February 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/28275294/anatomical-resection-of-hepatocellular-carcinoma-a-critical-review-of-the-procedure-and-its-benefits-on-survival
#9
REVIEW
Koo Jeong Kang, Keun Soo Ahn
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the third most frequent cause of cancer-related death. Advances in preoperative assessment of HCC (e.g., imaging studies and liver function tests), surgical techniques, and postoperative care have improved the surgical outcomes and survival of patients who undergo hepatic resection for HCC. However, in the last 20 years, the long-term survival after hepatectomy has remained unsatisfactory owing to the high rates of local recurrence and multicentric occurrence...
February 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28274681/what-is-diabetes-distress-and-how-can-we-measure-it-a-narrative-review-and-conceptual-model
#10
REVIEW
Kathryn Dennick, Jackie Sturt, Jane Speight
BACKGROUND: Diabetes distress is the negative emotional impact of living with diabetes. It has tangible clinical importance, being associated with sub-optimal self-care and glycemic control. Diabetes distress has been operationalized in various ways and several measures exist. Measurement clarity is needed for both scientific and clinical reasons. OBJECTIVES: To clarify the conceptualization and operationalization of diabetes distress, identify and distinguish relevant measures, and evaluate their appropriateness for this purpose...
February 14, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28269399/building-blocks-system-for-a-prosthesis-training-of-a-child-with-congenital-amputee
#11
Tomoya Shimokakimoto, Tomoyuki Ueno, Nanao Akimichi, Kenji Suzuki
Our objective is to provide a novel habilitation experience using play to children with special needs, in particular to those with congenital defects of the upper limbs. Our concept is a device-assisted motivational training session using tangible building block devices. In order to verify the feasibility of our concept with used bioToys in a clinical training session with occupational therapists. Our participant was a one-year-old girl with congenital amputation of the right upper limb. We verified that bioToys could be used in clinical training for a prosthesis, and could assist with both playful training and quantitative therapeutic evaluation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264025/both-anti-tnf-and-ctla4-ig-treatments-attenuate-the-disease-severity-of-staphylococcal-dermatitis-in-mice
#12
Manli Na, Wanzhong Wang, Ying Fei, Elisabet Josefsson, Abukar Ali, Tao Jin
BACKGROUND: RA patients being treated with biologics are known to have an increased risk of infections. We recently demonstrated that both CTLA4 Ig and anti-TNF treatment aggravate systemic Staphylococcus aureus (S. aureus) infection in mice, but with distinct clinical manifestations. However, the effects of CTLA4 Ig and anti-TNF treatments on a local S. aureus infection (e.g., skin infection) might differ from their effects on a systemic infection. AIMS: The aim of this study was to examine the differential effects of anti-TNF versus CTLA4 Ig treatment on S...
2017: PloS One
https://www.readbyqxmd.com/read/28257998/the-battle-of-nano-paclitaxel
#13
REVIEW
Alexandros Marios Sofias, Michael Dunne, Gert Storm, Christine Allen
Paclitaxel (PTX) is one of the three most widely used chemotherapeutic agents, together with doxorubicin and cisplatin, and is first or second line treatment for several types of cancers. In 2000, Taxol, the conventional formulation of PTX, became the best selling cancer drug of all time with annual sales of 1.6 billion. In 2005, the introduction of the albumin-based formulation of PTX, known as Abraxane, ended Taxol's monopoly of the PTX market. Abraxane's ability to push the Taxol innovator and generic formulations aside attracted fierce competition amongst competitors worldwide to develop their own unique, new and improved formulation of PTX...
February 28, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28248555/people-are-more-generous-to-a-partner-who-pays-attention-to-them
#14
Yohsuke Ohtsubo, Chiaki Yamaguchi
People use relatively low-cost signals to maintain close relationships, in which they engage in costlier exchanges of tangible support. Paying attention to a partner allows an individual to communicate his or her interest in the relationship with the partner. Previous studies have revealed that when Person A pays attention to Person B, B's feeling of intimacy toward A increases. If social attention strengthens the bond between A and B, it is predicted that A's attention will also increase B's generous behavior toward A...
January 2017: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
https://www.readbyqxmd.com/read/28237190/providing-feedback-practical-skills-and-strategies
#15
REVIEW
David Sarkany, Lori Deitte
Feedback is an essential component of education. It is designed to influence, reinforce, and change behaviors, concepts, and attitudes in learners. Although providing constructive feedback can be challenging, it is a learnable skill. The negative consequences of destructive feedback or lack of feedback all together are far-reaching. This article summarizes the components of constructive feedback and provides readers with tangible skills to enhance their ability to give effective feedback to learners and peers...
February 22, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28227642/building-blocks-system-for-a-prosthesis-training-of-a-child-with-congenital-amputee
#16
Tomoya Shimokakimoto, Tomoyuki Ueno, Nanao Akimichi, Kenji Suzuki, Tomoya Shimokakimoto, Tomoyuki Ueno, Nanao Akimichi, Kenji Suzuki, Kenji Suzuki, Tomoya Shimokakimoto, Tomoyuki Ueno, Nanao Akimichi
Our objective is to provide a novel habilitation experience using play to children with special needs, in particular to those with congenital defects of the upper limbs. Our concept is a device-assisted motivational training session using tangible building block devices. In order to verify the feasibility of our concept with used bioToys in a clinical training session with occupational therapists. Our participant was a one-year-old girl with congenital amputation of the right upper limb. We verified that bioToys could be used in clinical training for a prosthesis, and could assist with both playful training and quantitative therapeutic evaluation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225441/big-data-more-than-just-big-and-more-than-just-data
#17
Gregory A Spencer
According to an report, 90 percent of the data in the world today were created in the past two years. This statistic is not surprising given the explosion of mobile phones and other devices that generate data, the Internet of Things (e.g., smart refrigerators), and metadata (data about data). While it might be a stretch to figure out how a healthcare organization can use data generated from an ice maker, data from a plethora of rich and useful sources, when combined with an organization's own data, can produce improved results...
January 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28223290/nephrologists-perspectives-on-defining-and-applying-patient-centered-outcomes-in-hemodialysis
#18
Allison Tong, Wolfgang C Winkelmayer, David C Wheeler, Wim van Biesen, Peter Tugwell, Braden Manns, Brenda Hemmelgarn, Tess Harris, Sally Crowe, Angela Ju, Emma O'Lone, Nicole Evangelidis, Jonathan C Craig
BACKGROUND AND OBJECTIVES: Patient centeredness is widely advocated as a cornerstone of health care, but it is yet to be fully realized, including in nephrology. Our study aims to describe nephrologists' perspectives on defining and implementing patient-centered outcomes in hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Face-to-face, semistructured interviews were conducted with 58 nephrologists from 27 dialysis units across nine countries, including the United States, the United Kingdom, Australia, Austria, Belgium, Canada, Germany, Singapore, and New Zealand...
March 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28220145/where-sepsis-and-antimicrobial-resistance-countermeasures-converge
#19
Timothy J J Inglis, Nadia Urosevic
The United Nations General Assembly debate on antimicrobial resistance (AMR) recognizes the global significance of AMR. Much work needs to be done on technology capability and capacity to convert the strategic intent of the debate into operational plans and tangible outcomes. Enhancement of the biomedical science-clinician interface requires better exploitation of systems biology tools for in-laboratory and point of care methods that detect sepsis and characterize AMR. These need to link sepsis and AMR data with responsive, real-time surveillance...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28217563/arthroscopic-treatment-of-the-atraumatic-shoulder-instability-a-case-series-with-two-year-follow-up-evaluation
#20
Enrico Gervasi, Enrico Sebastiani, Enrico Cautero, Alessandro Spicuzza
BACKGROUND: The purpose of this work is to evaluate the results of arthroscopic capsulolabroplasty in patients affected by atraumatic shoulder instability (ASI). METHODS: A retrospective review was performed of 10 patients (7 women and 3 men) who underwent arthroscopic treatment of symptomatic ASI. Mean age at evaluation was 27.9 (19-35) years and the mean follow-up was 23.3 (12-37) months. We evaluated recurrence rate, range of movement, apprehension and relocation tests, hyperlaxity, and sport activity...
October 2016: Muscles, Ligaments and Tendons Journal
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