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https://www.readbyqxmd.com/read/28646186/magnetisation-switching-of-fept-nanoparticle-recording-medium-by-femtosecond-laser-pulses
#1
R John, M Berritta, D Hinzke, C Müller, T Santos, H Ulrichs, P Nieves, J Walowski, R Mondal, O Chubykalo-Fesenko, J McCord, P M Oppeneer, U Nowak, M Münzenberg
Manipulation of magnetisation with ultrashort laser pulses is promising for information storage device applications. The dynamics of the magnetisation response depends on the energy transfer from the photons to the spins during the initial laser excitation. A material of special interest for magnetic storage are FePt nanoparticles, for which switching of the magnetisation with optical angular momentum was demonstrated recently. The mechanism remained unclear. Here we investigate experimentally and theoretically the all-optical switching of FePt nanoparticles...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633605/controlling-response-dependence-in-the-measurement-of-change-using-the-rasch-model
#2
David Andrich
The advantages of using person location estimates from the Rasch model over raw scores for the measurement of change using a common test include the linearization of scores and the automatic handling of statistical properties of repeated measurements. However, the application of the model requires that the responses to the items are statistically independent in the sense that the specific responses to the items on the first time of testing do not affect the responses at a second time. This requirement implies that the responses to the items at both times of assessment are governed only by the invariant location parameters of the items at the two times of testing and the location parameters of each person each time...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28617999/adenosine-an-endogenous-mediator-in-the-pathogenesis-of-gynecological-cancer
#3
REVIEW
Amirhossein Bahreyni, Seyed Sattar Samani, Elnaz Ghorbani, Farzad Rahmani, Reza Khayami, Younes Toroghian, Reihane Behnam-Rassouli, Majid Khazaei, Mikhail Ryzhikov, Mohammad Reza Parizadeh, Malihe Hasanzadeh, Amir Avan, Seyed Mahdi Hassanian
Extracellular concentration of adenosine increases in the hypoxic tumor microenvironment. Adenosine signaling regulates apoptosis, angiogenesis, metastasis and immune suppression in cancer cells. Adenosine-induced cell responses depend upon different subtypes of adenosine receptors activation and type of cancer. Suppression of adenosine signaling via inhibition of adenosine receptors or adenosine generating enzymes including CD39 and CD73 on ovarian or cervical cancer cells is a potentially novel therapeutic approach for gynecological cancer patients...
June 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28584283/phytohormone-ethylene-responsive-arabidopsis-organ-growth-under-light-is-in-the-fine-regulation-of-photosystem-ii-deficiency-inducible-akin10-expression
#4
Geun-Don Kim, Young-Hee Cho, Sang-Dong Yoo
For photoautotrophic plants, light-dependent photosynthesis plays an important role in organismal growth and development. Under light, Arabidopsis hypocotyl growth is promoted by the phytohormone ethylene. Despite well-characterized ethylene signaling pathways, the functions of light in the hormone-inducible growth response still remain elusive. Our cell-based functional and plant-system-based genetic analyses with biophysical and chemical tools showed that a chemical blockade of photosystem (PS) II activity affects ethylene-induced hypocotyl response under light...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28583384/hydrocarbon-induced-changes-in-proteins-and-fatty-acids-profiles-of-raoultella-ornithinolytica-m03
#5
A Zdarta, J Tracz, M Luczak, U Guzik, E Kaczorek
Microorganisms can support environmental restoration by biodegradation of hydrocarbons but the mechanism of this process has been not described in detail yet. We present the effect of benzene derivatives on Raoultella ornithinolytica M03 cell composition. Comparison of the cell response after short-term and long-term stress revealed significant differences in surface properties, fatty acid composition and proteins profile. R. ornithinolytica M03 after long-term stress was characterized by lower cell surface hydrophobicity and much higher inner membrane permeability...
June 2, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28573821/overexpression-of-the-human-antigen-r-suppresses-the-immediate-paradoxical-proliferation-of-melanoma-cell-subpopulations-in-response-to-suboptimal-braf-inhibition
#6
Marylise Fernandez, Hedwig Sutterlüty-Fall, Christoph Schwärzler, Sylvain Lemeille, Wolf-Henning Boehncke, Rastine Merat
Tumor plasticity and the heterogeneous response of melanoma cells to targeted therapies are major limits for the long-term efficacy of this line of therapy. Targeting tumor plasticity is theoretically possible through the modulation of the expression of RNA-binding proteins which can affect many different compensatory mechanisms of the adaptive response of malignant cells to targeted therapies. Human antigen R (HuR) is a modulator of gene expression and a transacting factor in the mRNA-processing machinery used in the cell stress response, and is a potential target for reducing tumor plasticity...
June 1, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28567024/dissociating-attention-and-eye-movements-in-a-quantitative-analysis-of-attention-allocation
#7
Gene M Heyman, Jaime Montemayor, Katherine A Grisanzio
In a recent paper, we introduced a method and equation for inferring the allocation of attention on a continuous scale. The size of the stimuli, the estimated size of the fovea, and the pattern of results implied that the subjects' responses reflected shifts in covert attention rather than shifts in eye movements. This report describes an experiment that tests this implication. We measured eye movements. The monitor briefly displayed (e.g., 130 ms) two small stimuli (≈1.0° × 1.2°), situated one atop another...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28550019/measuring-ability-to-assess-claims-about-treatment-effects-a-latent-trait-analysis-of-items-from-the-claim-evaluation-tools-database-using-rasch-modelling
#8
Astrid Austvoll-Dahlgren, Øystein Guttersrud, Allen Nsangi, Daniel Semakula, Andrew D Oxman
BACKGROUND: The Claim Evaluation Tools database contains multiple-choice items for measuring people's ability to apply the key concepts they need to know to be able to assess treatment claims. We assessed items from the database using Rasch analysis to develop an outcome measure to be used in two randomised trials in Uganda. Rasch analysis is a form of psychometric testing relying on Item Response Theory. It is a dynamic way of developing outcome measures that are valid and reliable. OBJECTIVES: To assess the validity, reliability and responsiveness of 88 items addressing 22 key concepts using Rasch analysis...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28545523/l-mimosine-and-hypoxia-can-increase-angiogenin-production-in-dental-pulp-derived-cells
#9
Klara Janjić, Michael Edelmayer, Andreas Moritz, Hermann Agis
BACKGROUND: Angiogenin is a key molecule in the healing process which has been successfully applied in the field of regenerative medicine. The role of angiogenin in dental pulp regeneration is unclear. Here we aimed to reveal the impact of the hypoxia mimetic agent L-mimosine (L-MIM) and hypoxia on angiogenin in the dental pulp. METHODS: Human dental pulp-derived cells (DPC) were cultured in monolayer and spheroid cultures and treated with L-MIM or hypoxia. In addition, tooth slice organ cultures were applied to mimic the pulp-dentin complex...
May 25, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28543754/validating-the-european-health-literacy-survey-questionnaire-in-people-with-type-2-diabetes-latent-trait-analyses-applying-multidimensional-rasch-modelling-and-confirmatory-factor-analysis
#10
Hanne Søberg Finbråten, Kjell Sverre Pettersen, Bodil Wilde-Larsson, Gun Nordström, Anne Trollvik, Øystein Guttersrud
AIM: To validate the European Health Literacy Survey Questionnaire (HLS-EU-Q47) in people with type 2 diabetes mellitus. BACKGROUND: The HLS-EU-Q47 latent variable is outlined in a framework with four cognitive domains integrated in three health domains, implying 12 theoretically defined subscales. Valid and reliable health literacy measurers are crucial to effectively adapt health communication and education to individuals and groups of patients. DESIGN: Cross-sectional study applying confirmatory latent trait analyses...
May 24, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28531178/zebrafish-exposure-to-environmentally-relevant-concentration-of-depleted-uranium-impairs-progeny-development-at-the-molecular-and-histological-levels
#11
Olivier Armant, Kewin Gombeau, Sophia Murat El Houdigui, Magali Floriani, Virginie Camilleri, Isabelle Cavalie, Christelle Adam-Guillermin
Uranium is an actinide naturally found in the environment. Anthropogenic activities lead to the release of increasing amounts of uranium and depleted uranium (DU) in the environment, posing potential risks to aquatic organisms due to radiological and chemical toxicity of this radionucleide. Although environmental contaminations with high levels of uranium have already been observed, chronic exposures of non-human species to levels close to the environmental quality standards remain scarcely characterized. The present study focused on the identification of the molecular pathways impacted by a chronic exposure of zebrafish to 20 μg/L of DU during 10 days...
2017: PloS One
https://www.readbyqxmd.com/read/28530798/heterogeneous-molecular-catalysis-of-electrochemical-reactions-volcano-plots-and-catalytic-tafel-plots
#12
Cyrille Costentin, Jean-Michel Savéant
We analyze here, in the framework of heterogeneous molecular catalysis, the reasons for the occurrence or nonoccurrence of volcanoes upon plotting the kinetics of the catalytic reaction versus the stabilization free energy of the primary intermediate of the catalytic process. As in the case of homogeneous molecular catalysis or catalysis by surface-active metallic sites, a strong motivation of such studies relates to modern energy challenges, particularly those involving small molecules, such as water, hydrogen, oxygen, proton, and carbon dioxide...
June 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28529478/slow-and-fast-responses-two-mechanisms-of-trial-outcome-processing-revealed-by-eeg-oscillations
#13
Nikita A Novikov, Yulia M Nurislamova, Natalia A Zhozhikashvili, Evgenii E Kalenkovich, Anna A Lapina, Boris V Chernyshev
Cognitive control includes maintenance of task-specific processes related to attention, and non-specific regulation of motor threshold. Depending upon the nature of the behavioral tasks, these mechanisms may predispose to different kinds of errors, with either increased or decreased response time (RT) of erroneous responses relative to correct responses. Specifically, slow responses are related to attentional lapses and decision uncertainty, these conditions tending to delay RTs of both erroneous and correct responses...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28515351/local-immune-response-depends-on-p16ink4a-status-of-primary-tumor-in-vulvar-squamous-cell-carcinoma
#14
Jacek J Sznurkowski, Anton Żawrocki, Wojciech Biernat
BACKGROUND: The p16Ink4a is not a surrogate marker for high-risk human papilloma virus (HPV) genotypes but indicates better prognosis in vulvar squamous cell carcinoma patients. Our recent study confirmed substantial mismatch between p16Ink4a and high-risk HPV-status as well as revealed that p16Ink4a-overexpression itself is an independent prognostic factor for vulvar cancer. AIM: To determine significance of the tumor infiltrating immune cells and p16Ink4a-status for better outcome of patients with vulvar cancer...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514402/-psychoemotional-and-autonomic-states-in-patients-with-cholelithiasis
#15
Ya M Vakhrushev, N A Khokhlacheva, N N Sergeeva
AIM: To investigate the psychoemotional and autonomic states of patients with biliary system diseases and to determine their significance in the development of cholelithiasis. SUBJECTS AND METHODS: A total of 396 patients with stage 1 cholelithiasis were examined. The results of hepatobiliary ultrasonography, multifractional duodenal probing, followed by macroscopic, microscopic, and biochemical examinations of bile (the total concentration of bile acids and cholesterol, by subsequently calculating the cholate-cholesterol ratio) were used to verify the diagnosis...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28489826/a-rhodopsin-in-the-brain-functions-in-circadian-photoentrainment-in-drosophila
#16
Jinfei D Ni, Lisa S Baik, Todd C Holmes, Craig Montell
Animals partition their daily activity rhythms through their internal circadian clocks, which are synchronized by oscillating day-night cycles of light. The fruitfly Drosophila melanogaster senses day-night cycles in part through rhodopsin-dependent light reception in the compound eye and photoreceptor cells in the Hofbauer-Buchner eyelet. A more noteworthy light entrainment pathway is mediated by central pacemaker neurons in the brain. The Drosophila circadian clock is extremely sensitive to light. However, the only known light sensor in pacemaker neurons, the flavoprotein cryptochrome (Cry), responds only to high levels of light in vitro...
May 18, 2017: Nature
https://www.readbyqxmd.com/read/28470129/the-influence-of-environment-experiences-of-users-of-myoelectric-arm-prosthesis-a-qualitative-study
#17
Cathrine Widehammar, Ingvor Pettersson, Gunnel Janeslätt, Liselotte Hermansson
BACKGROUND: Prostheses are used to varying degrees; however, little is known about how environmental aspects influence this use. OBJECTIVES: To describe users' experiences of how environmental factors influence their use of a myoelectric arm prosthesis. STUDY DESIGN: Qualitative and descriptive. METHODS: A total of 13 patients previously provided with a myoelectric prosthetic hand participated. Their age, sex, deficiency level, etiology, current prosthesis use, and experience varied...
May 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28468885/rubicon-modulates-antiviral-type-i-ifn-signaling-by-targeting-irf3-dimerization
#18
Jae-Hoon Kim, Tae-Hwan Kim, Hyun-Cheol Lee, Chamilani Nikapitiya, Md Bashir Uddin, Min-Eun Park, Eun Seo Lee, Kiramage Chathuranga, Thilina U B Herath, W A Gayan Chathuranga, Jong-Soo Lee
Rubicon is a part of a Beclin-1-Vps34-containing autophagy complex. Rubicon induces antimicrobial responses upon TLR stimulation, and functions as a feedback inhibitor to prevent unbalanced proinflammatory responses depending on dectin-1 signaling. However, the role played by Rubicon during antiviral immune responses, particularly the type I interferon responses remains largely unknown. Here, we report that Rubicon acts as a negative regulator for virus-triggered IFN signaling. Knockdown of Rubicon promoted type I interferon signaling and inhibited virus replication, while overexpression of Rubicon has the opposite effect...
May 3, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28458071/understanding-the-impact-of-school-tobacco-policies-on-adolescent-smoking-behaviour-a-realist-review
#19
REVIEW
Michael Schreuders, Paulien A W Nuyts, Bas van den Putte, Anton E Kunst
BACKGROUND: Secondary schools increasingly implement school tobacco policies (STPs) to decrease adolescents' smoking. Recent studies suggested that STPs' impact depends on their implementation. We examined adolescents' cognitive and behavioural responses to STPs that impact adolescents' smoking and how these responses depend on elements of STPs' implementation. METHOD: To examine STPs and adolescent smoking, we performed a realist review, which is an explanatory approach that synthesizes existing evidence into a program theory that links elements of STPs' implementation to outcomes by specifying its underlying generative mechanisms...
June 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28454101/mir-146a-negatively-regulates-dectin-1-induced-inflammatory-responses
#20
Leilei Du, Xu Chen, Zhimin Duan, Caixia Liu, Rong Zeng, Qing Chen, Min Li
Dectin-1 is the critical sensor for β-glucan from Candida which is the most common human fungal pathogen and cause superficial and system infection. MicroRNAs (miRNAs) play crucial roles in regulating innate immunity. However, the functional role of miRNAs in inflammatory response dependent on the activation of dectin-1 pathway has not been defined. In the present study, we found insoluble β-glucan from the cell wall of Candida albicans (CaIG) was able to increase the production of of IL-6 and TNFα through Dectin-1-Syk-NF-κB and p38MAPK pathway...
June 6, 2017: Oncotarget
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