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https://www.readbyqxmd.com/read/29329584/validity-of-the-school-setting-interview-for-students-with-special-educational-needs-in-regular-high-school-a-rasch-analysis
#1
Moa Yngve, Michaela Munkholm, Helene Lidström, Helena Hemmingsson, Elin Ekbladh
BACKGROUND: Participation in education is a vital component of adolescents' everyday life and a determinant of health and future opportunities in adult life. The School Setting Interview (SSI) is an instrument which assesses student-environment fit and reflects the potential needs for adjustments to enhance students' participation in school activities. The aim of the study was to investigate the psychometric properties of the SSI for students with special educational needs in regular high school...
January 12, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29323763/calcium-responsive-liposomes-via-a-synthetic-lipid-switch
#2
Jinchao Lou, Adam Carr, Alexa Watson, Samuel Mattern-Schain, Michael D Best
Liposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical composition using liposomes sensitized to calcium, a target chosen due to its key roles in biology and disease. To demonstrate this principle, we synthesized calcium responsive lipid switch 1, designed to undergo conformational changes upon calcium binding that perturb membrane integrity, thereby promoting release. This was shown through fluorescence-based release assays via dose-dependent response depending on the percentage of 1 in liposomes, with minimal background leakage in controls...
January 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29321512/phenotypic-responses-to-interspecies-competition-and-commensalism-in-a-naturally-derived-microbial-co-culture
#3
Nymul Khan, Yukari Maezato, Ryan S McClure, Colin J Brislawn, Jennifer M Mobberley, Nancy Isern, William B Chrisler, Lye Meng Markillie, Brett M Barney, Hyun-Seob Song, William C Nelson, Hans C Bernstein
The fundamental question of whether different microbial species will co-exist or compete in a given environment depends on context, composition and environmental constraints. Model microbial systems can yield some general principles related to this question. In this study we employed a naturally occurring co-culture composed of heterotrophic bacteria, Halomonas sp. HL-48 and Marinobacter sp. HL-58, to ask two fundamental scientific questions: 1) how do the phenotypes of two naturally co-existing species respond to partnership as compared to axenic growth? and 2) how do growth and molecular phenotypes of these species change with respect to competitive and commensal interactions? We hypothesized - and confirmed - that co-cultivation under glucose as the sole carbon source would result in competitive interactions...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313503/telemedicine-in-dermatology-during-external-operations
#4
J J Morand
Telemedicine makes it possible to refer clinical, laboratory, and radiological questions to distant experts, sometimes in real time. This study examines a selection of internet messages sent by physicians carrying out overseas missions or assigned to remote locations and analyzes the interest but also the limitations of teleconsultations in dermatology. The effectiveness of the response depended on the quality of the message, including correct symptom descriptions, thorough history-taking, and the definition of the attached images, as well as the field experience of the specialists receiving the message...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29313237/simians-in-the-shape-school-a-comparative-study-of-executive-attention
#5
Kristin French, Michael J Beran, Kimberly Andrews Espy, David A Washburn
Executive functions (EF) have been studied extensively in children and adults. However, EF tasks for young children can be difficult to administer and interpret. Espy (1997, Developmental Neuropsychology, 13, 495-499) designed the Shape School task to measure inhibition and switching in preschool-aged children. Shape School presents cartoon-like characters that children must flexibly name by their color, their shape, or both, depending on cues that indicate the appropriate rule. Shape School has been found to be age sensitive as well as predictive of performance on other EF tasks...
January 8, 2018: Learning & Behavior
https://www.readbyqxmd.com/read/29304428/approach-towards-the-porous-fibrous-structure-of-the-periodontal-ligament-using-micro-computerized-tomography-and-finite-element-analysis
#6
J Ortún-Terrazas, J Cegoñino, U Santana-Penín, U Santana-Mora, A Pérez Del Palomar
The periodontal ligament (PDL) is a porous and fibrous soft tissue situated around the tooth, which plays a key role in the transmission of loads from the tooth to the alveolar bone of the mandible. Although several studies have tried to characterize its mechanical properties, the behaviour of this tissue is not clear yet. In this study, a new simulation methodology based on a material model which considers the contribution of porous and fibrous structure with different material model formulations depending on the effort direction is proposed...
December 28, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29281320/sensory-behaviors-in-minimally-verbal-children-with-autism-spectrum-disorder-how-and-when-do-caregivers-respond
#7
Clare Harrop, Nicole Tu, Rebecca Landa, Ann Kasier, Connie Kasari
Sensory behaviors are widely reported in autism spectrum disorder (ASD). However, the impact of these behaviors on families remains largely unknown. This study explored how caregivers of minimally verbal children with ASD responded to their child's sensory behaviors. Using a mixed-methods approach, we examined two variables for each endorsed child behavior: (1) Did the caregiver respond/try to change the behavior? and (2) What response did they employ? Caregivers did not differ in the frequency of responses to hypo- or hyper-responsive behaviors but employed different responses...
January 2018: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29277715/direct-modification-of-the-5-ht3-receptor-current-by-some-anticancer-drugs
#8
Yukiko Nakamura, Yusuke Ishida, Makoto Kondo, Shoichi Shimada
The serotonin (5-hydroxytryptamine) type 3 (5-HT3) receptor is an important target in the control of emesis, and 5-HT3 receptor antagonists are effective against the early phase chemotherapy evoked vomiting. We recently reported that the anticancer drugs irinotecan and topotecan directly modulate the 5-HT-mediated 5-HT3 receptor current in vitro. In addition, the drug response depends on the 5-HT3 subunit composition. Here, we explored the effects of 35 anticancer drugs on the 5-HT3 receptor current. We microinjected Xenopus laevis oocytes with human 5-HT3A cRNA or a combination of human 5-HT3A and human 5-HT3B cRNA, and performed two-electrode voltage clamp recordings of 5-HT3A and 5-HT3AB receptor currents in the presence of each of the 35 drugs...
December 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29242034/dendritic-cells-in-the-regulation-of-immunity-and-inflammation
#9
REVIEW
Cheng Qian, Xuetao Cao
As potent antigen-presenting cells, dendritic cells (DCs) comprise the most heterogeneous cell population with significant cellular phenotypic and functional plasticity. They form a sentinel network to modulate immune responses, since intrinsic cellular mechanisms and complex external, environmental signals endow DCs with the distinct capacity to induce protective immunity or tolerance to self. Interactions between DCs and other cells of the immune system mediate this response. This interactive response depends on DC maturation status and subtype, as well as the microenvironment of the tissue location and DC-intrinsic regulators...
December 11, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29222473/hypoxia-inducible-factor-1%C3%AE-is-essential-for-macrophage-mediated-erythroblast-proliferation-in-acute-friend-retrovirus-infection
#10
Timm Schreiber, Theresa Quinting, Ulf Dittmer, Joachim Fandrey, Kathrin Sutter
Macrophages are the frontline of defence against foreign microorganisms, including bacteria, parasites, and viruses. During acute viral infection, macrophages must invade the inflamed tissue toward low oxygen concentrations, where genetic cellular responses depend on hypoxia-inducible factors (HIF). In the study reported here we investigated the role of HIF-1α in macrophage function during acute retroviral infection. Wild-type and myeloid cell-specific HIF-1α knockout mice were infected with Friend retrovirus (FV), and immune response was analysed 7 and 10 days after infection...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208313/pursuit-of-a-method-for-single-administration-of-pfsh-for-superstimulation-in-cattle-what-we-have-learned
#11
Gabriel A Bó, Dragan R Rogan, Reuben J Mapletoft
A single dose protocol of FSH for superstimulation in cattle may improve compliance and superovulatory response. A single subcutaneous (sc) administration of pFSH was efficacious, but response depended on body condition and injection site; the adipose tissue pad behind the shoulder was most efficacious. Inconsistent results in Holsteins were partially overcome by sc administration of 75% of the total pFSH dose behind the shoulder on the first day followed by 25% 48 h later. An alternative would be to combine FSH with polymers that cause it to be released slowly over several days...
September 28, 2017: Theriogenology
https://www.readbyqxmd.com/read/29194409/auxin-information-processing-partners-and-interactions-beyond-the-usual-suspects
#12
REVIEW
Thea van den Berg, Kirsten H Ten Tusscher
Auxin plays a major role in a variety of processes involved in plant developmental patterning and its adaptation to environmental conditions. Therefore, an important question is how specificity in auxin signalling is achieved, that is, how a single signalling molecule can carry so many different types of information. In recent years, many studies on auxin specificity have been published, unravelling increasingly more details on differential auxin sensitivity, expression domains and downstream partners of the auxin receptors (transport inhibitor response 1 (TIR1) and other auxin signaling F-box proteins (AFB)), transcriptional repressors that are degraded in response to auxin (AUX/IAA) and downstream auxin response factors (ARF) that together constitute the plant's major auxin response pathways...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29188106/non-invasive-assessment-of-human-cone-photoreceptor-function
#13
Robert F Cooper, William S Tuten, Alfredo Dubra, David H Brainard, Jessica I W Morgan
Vision begins when light isomerizes the photopigments within photoreceptors. Noninvasive cellular-scale observation of the structure of the human photoreceptor mosaic is made possible through the use of adaptive optics (AO) enhanced ophthalmoscopes, but establishing noninvasive objective measures of photoreceptor function on a similar scale has been more difficult. AO ophthalmoscope images acquired with near-infrared light show that individual cone photoreceptor reflectance can change in response to a visible stimulus...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29186797/carbon-nanofiber-cement-sensors-to-detect-strain-and-damage-of-concrete-specimens-under-compression
#14
(no author information available yet)
Cement composites with nano-additions have been vastly studied for their functional applications, such as strain and damage sensing. The capacity of a carbon nanofiber (CNF) cement paste has already been tested. However, this study is focused on the use of CNF cement composites as sensors in regular concrete samples. Different measuring techniques and humidity conditions of CNF samples were tested to optimize the strain and damage sensing of this material. In the strain sensing tests (for compressive stresses up to 10 MPa), the response depends on the maximum stress applied...
November 24, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29160562/aqueous-extract-of-yellow-maca-lepidium-meyenii-improves-sperm-count-in-experimental-animals-but-response-depends-on-hypocotyl-size-ph-and-routes-of-administration
#15
L Sanchez-Salazar, G F Gonzales
Lepidium meyenii, a Peruvian plant growing over 4000 m.a.s.l., has effects on nutrition and fertility. The purpose of this study was to evaluate the sperm count in 105 male mice receiving boiled aqueous extract of yellow maca hypocotyls from different sizes, under different pH conditions and using two different routes of administration. Five mice per group were treated daily for 3 days with vehicle (oral and intraperitoneal) or maca aqueous extracts (5 mg/0.5 ml/day) belonging to the first, second, third and fourth categories, according to their hypocotyl size...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29152417/assessing-mongolian-gerbil-emotional-behavior-effects-of-two-shock-intensities-and-response-independent-shocks-during-an-extended-inhibitory-avoidance-task
#16
Camilo Hurtado-Parrado, Camilo González-León, Mónica A Arias-Higuera, Angelo Cardona, Lucia G Medina, Laura García-Muñoz, Christian Sánchez, Julián Cifuentes, Juan Carlos Forigua, Andrea Ortiz, Cesar A Acevedo-Triana, Javier L Rico
Despite step-down inhibitory avoidance procedures that have been widely implemented in rats and mice to study learning and emotion phenomena, performance of other species in these tasks has received less attention. The case of the Mongolian gerbil is of relevance considering the discrepancies in the parameters of the step-down protocols implemented, especially the wide range of foot-shock intensities (i.e., 0.4-4.0 mA), and the lack of information on long-term performance, extinction effects, and behavioral patterning during these tasks...
2017: PeerJ
https://www.readbyqxmd.com/read/29150962/genotype-and-diet-affect-resistance-survival-and-fecundity-but-not-fecundity-tolerance
#17
Megan A M Kutzer, Joachim Kurtz, Sophie A O Armitage
Insects are exposed to a variety of potential pathogens in their environment, many of which can severely impact fitness and health. Consequently, hosts have evolved resistance and tolerance strategies to suppress or cope with infections. Hosts utilising resistance improve fitness by clearing or reducing pathogen loads and hosts utilising tolerance reduce harmful fitness effects per pathogen load. To understand variation in, and selective pressures on resistance and tolerance we asked to what degree they are shaped by host genetic background, whether plasticity in these responses depends upon dietary environment, and whether there are interactions between these two factors...
November 18, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29142017/modelling-the-effects-of-phylogeny-and-body-size-on-within-host-pathogen-replication-and-immune-response
#18
Soumya Banerjee, Alan S Perelson, Melanie Moses
Understanding how quickly pathogens replicate and how quickly the immune system responds is important for predicting the epidemic spread of emerging pathogens. Host body size, through its correlation with metabolic rates, is theoretically predicted to impact pathogen replication rates and immune system response rates. Here, we use mathematical models of viral time courses from multiple species of birds infected by a generalist pathogen (West Nile Virus; WNV) to test more thoroughly how disease progression and immune response depend on mass and host phylogeny...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29138480/nitric-oxide-contributes-to-high-salt-perception-in-a-blood-sucking-insect-model
#19
Agustina Cano, Gina Pontes, Valeria Sfara, Diego Anfossi, Romina B Barrozo
In all organisms, salts produce either appetitive or aversive responses depending on the concentration. While low-salt concentration in food elicits positive responses to ingest, high-salt triggers aversion. Still the mechanisms involved in this dual behavior have just started to be uncovered in some organisms. In Rhodnius prolixus, using pharmacological and behavioral assays, we demonstrated that upon high-salt detection in food a nitric oxide (NO) dependent cascade is activated. This activation involves a soluble guanylate cyclase (sGC) and the production of cyclic guanosine monophosphate (cGMP)...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29134295/rod-versus-cone-driven-ergs-at-different-stimulus-sizes-in-normal-subjects-and-retinitis-pigmentosa-patients
#20
Avinash J Aher, Declan J McKeefry, Neil R A Parry, John Maguire, I J Murray, Tina I Tsai, Cord Huchzermeyer, Jan Kremers
PURPOSE: To study how rod- and cone-driven responses depend on stimulus size in normal subjects and patients with retinitis pigmentosa (RP), and to show that comparisons between responses to full-field (FF) and smaller stimuli can be useful in diagnosing and monitoring disorders of the peripheral retina without the need for lengthy dark adaptation periods. METHOD: The triple silent substitution technique was used to isolate L-cone-, M-cone- and rod-driven ERGs with 19, 18 and 33% photoreceptor contrasts, respectively, under identical mean luminance conditions...
November 13, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
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