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https://www.readbyqxmd.com/read/29220877/increased-circulating-plasma-cells-detected-by-flow-cytometry-predicts-poor-prognosis-in-patients-with-plasma-cell-myeloma
#1
Mi Hyun Bae, Chan-Jeoung Park, Bo Hyun Kim, Young-Uk Cho, Seongsoo Jang, Dong-Hyun Lee, Eul-Ju Seo, Dok Hyun Yoon, Jung-Hee Lee, Cheolwon Suh
BACKGROUND: Flow cytometry (FC) is a reliable tool for diagnosing and monitoring of plasma cell myeloma (PCM). Recent studies used FC for quantifying plasma cells (PCs) in peripheral blood (PB) using various panels, and an adverse prognostic effect of circulating PCs (cPCs) has been reported. We investigated the prognostic implication of cPCs quantified using a simple panel in patients with PCM. METHODS: Bone marrow (BM) and PB of 85 patients with PCM were analyzed by five-color FC at time of diagnosis...
December 8, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29220859/single-and-double-tunnel-endoscopic-submucosal-tunnel-dissection-for-large-superficial-esophageal-squamous-cell-neoplasms
#2
Wengang Zhang, Yaqi Zhai, Ningli Chai, Enqiang Linghu, Huikai Li, Xiuxue Feng
Background and study aim Single-tunnel endoscopic submucosal tunnel dissection (ESTD) has shown promising preliminary efficacy for large superficial esophageal squamous cell neoplasms (SESCNs). This study reports the outcomes of both single- and double-tunnel ESTD for large SESCNs, and compares the efficiency of the two techniques for treating circumferential SESCNs. Patients and methods 46 patients with large SESCNs underwent ESTD at a single hospital between October 2011 and March 2016. Relevant clinical data were retrospectively collected and analyzed...
December 8, 2017: Endoscopy
https://www.readbyqxmd.com/read/29220828/prediction-of-radiation-esophagitis-in-non-small-cell-lung-cancer-using-clinical-factors-dosimetric-parameters-and-pretreatment-cytokine-levels
#3
Peter G Hawkins, Philip S Boonstra, Stephen T Hobson, James A Hayman, Randall K Ten Haken, Martha M Matuszak, Paul Stanton, Gregory P Kalemkerian, Theodore S Lawrence, Matthew J Schipper, Feng-Ming Spring Kong, Shruti Jolly
Radiation esophagitis (RE) is a common adverse event associated with radiotherapy for non-small cell lung cancer (NSCLC). While plasma cytokine levels have been correlated with other forms of radiation-induced toxicity, their association with RE has been less well studied. We analyzed data from 126 patients treated on 4 prospective clinical trials. Logistic regression models based on combinations of dosimetric factors [maximum dose to 2 cubic cm (D2cc) and generalized equivalent uniform dose (gEUD)], clinical variables, and pretreatment plasma levels of 30 cytokines were developed...
December 5, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29220820/application-of-an-in-situ-soil-sampler-for-assessing-subsurface-biogeochemical-dynamics-in-a-diesel-contaminated-coastal-site-during-soil-flushing-operations
#4
Man Jae Kwon, Edward J O'Loughlin, Baknoon Ham, Yunho Hwang, Moojoon Shim, Soonjae Lee
Subsurface biogeochemistry and contaminant dynamics during the remediation of diesel-contamination by in-situ soil flushing were investigated at a site located in a coastal region. An in-situ sampler containing diesel-contaminated soils separated into two size fractions (<0.063- and <2-mm) was utilized in two monitoring wells: DH1 (located close to the injection and extraction wells for in-situ soil flushing) and DH2 (located beyond sheet piles placed to block the transport of leaked diesel). Total petroleum hydrocarbon (TPH) concentrations and biogeochemical properties were monitored both in soil and groundwater for six months...
December 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29220815/influence-of-fermentation-liquid-from-waste-activated-sludge-on-anoxic-oxic-membrane-bioreactor-performance-nitrogen-removal-membrane-fouling-and-microbial-community
#5
Xiaomeng Han, Zhen Zhou, Xiaojie Mei, Yan Ma, Zhenfang Xie
In order to investigate effects of waste activated sludge (WAS) fermentation liquid on anoxic/oxic- membrane bioreactor (A/O-MBR), two A/O-MBRs with and without WAS fermentation liquid addition were operated in parallel. Results show that addition of WAS fermentation liquid clearly improved denitrification efficiency without deterioration of nitrification, while severe membrane fouling occurred. WAS fermentation liquid resulted in an elevated production of proteins and humic acids in bound extracellular polymeric substance (EPS) and release of organic matter with high MW fractions in soluble microbial product (SMP) and loosely bound EPS (LB-EPS)...
December 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29220812/bioethanol-potential-of-eucalyptus-obliqua-sawdust-using-gamma-valerolactone-fractionation
#6
Raymond M Trevorah, Tien Huynh, Tony Vancov, Maazuza Z Othman
Optimisation of conditions for gamma-valerolactone (GVL) pretreatment of Australian eucalyptus sawdust for high cellulose biomass and bioethanol production was demonstrated. Pretreatment parameters investigated included GVL concentrations of 35-50% w/w, temperatures of 120-180 °C and reaction durations of 0.5-2.0 h. Optimum conditions were determined using the response surface method (RSM) and central composite face-centred design. Cellulose content increased from 39.9% to a maximum of 89.3% w/w using treatments with 50% GVL at 156 °C for 0...
November 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29220743/the-cigarette-dependence-scale-and-heaviness-of-smoking-index-as-predictors-of-smoking-cessation-after-10weeks-of-nicotine-replacement-therapy-and-at-6-month-follow-up
#7
Laurie Zawertailo, Sabrina Voci, Peter Selby
INTRODUCTION: The reliability and validity of the Cigarette Dependence Scale (CDS) has been tested in online studies and compared with other tobacco dependence measures. Findings regarding its ability to predict smoking cessation have been mixed. We examined whether the CDS predicted cessation among a sample that received nicotine replacement therapy (NRT) at a community workshop and assessed the incremental predictive validity of the CDS-5 and CDS-12 over the 2-item Heaviness of Smoking Index (HSI)...
November 27, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29220729/comparison-of-dynamic-cervical-implant-versus-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-single-level-cervical-degenerative-disc-disease-a-five-year-follow-up
#8
Ce Zhu, Xi Yang, Lei Wang, Bo-Wen Hu, Li-Min Liu, Lin-Nan Wang, Hao Liu, Yue-Ming Song
OBJECTIVE: To compare clinical and radiographic outcomes of dynamic cervical implant(DCI) with anterior cervical discectomy and fusion(ACDF) in the treatment of single-level cervical degenerative disc disease (CDDD) 5 years after surgery. PATIENTS AND METHODS: Forty-three patients with DCI were matched one-to-one with patients with ACDF based on age, gender, and operative segment in this retrospective study. All patients had been followed up for more than 5 years...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29220717/microbial-electricity-driven-anoxic-ammonium-removal
#9
Anna Vilajeliu-Pons, Christin Koch, Maria D Balaguer, Jesús Colprim, Falk Harnisch, Sebastià Puig
Removal of nitrogen, mainly in form of ammonium (NH4+), in wastewater treatment plants (WWTPs) is a highly energy demanding process, mainly due to aeration. It causes costs of about half a million Euros per year in an average European WWTP. Alternative, more economical technologies for the removal of nitrogen compounds from wastewater are required. This study proves the complete anoxic conversion of ammonium (NH4+) to dinitrogen gas (N2) in continuously operated bioelectrochemical systems at the litre-scale...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29220716/self-accelerating-sulfur-reduction-via-polysulfide-to-realize-a-high-rate-sulfidogenic-reactor-for-wastewater-treatment
#10
Liang Zhang, Zefeng Zhang, Rongrong Sun, Shuang Liang, Guang-Hao Chen, Feng Jiang
Sulfur reduction is a promising alternative to sulfate reduction as it can generate sulfide at a low cost for the precipitation of heavy metals or autotrophic denitrification in wastewater treatment. However, the extremely low water solubility of elemental sulfur limits its bioavailability and results in a low sulfur-reduction rate. Polysulfide, which is naturally generated through reactions between sulfur and sulfide, can enhance the bioavailability of sulfur and thus contribute to high-rate sulfur reduction...
November 28, 2017: Water Research
https://www.readbyqxmd.com/read/29220511/unbiased-estimate-of-synonymous-and-non-synonymous-substitution-rates-with-non-stationary-base-composition
#11
Laurent Guéeguen, Laurent Duret
The measurement of synonymous and non-synonymous substitution rates (dS and dN) is useful for assessing selection operating on protein sequences or for investigating mutational processes affecting genomes. In particular, the ratio dNdS is expected to be a good proxy for ω, the ratio of fixation robabilities of non-synonymous mutations relative to that of neutral mutations. Standard methods for estimating dN, dS or ω rely on the assumption that the base composition of sequences is at the equilibrium of the evolutionary process...
December 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29220497/post-treatment-hrp2-clearance-in-patients-with-uncomplicated-plasmodium-falciparum-malaria
#12
Mateusz M Plucinski, Pedro Rafael Dimbu, Filomeno Fortes, Salim Abdulla, Saumu Ahmed, Julie Gutman, S Patrick Kachur, Aida Badiane, Daouda Ndiaye, Eldin Talundzic, Naomi Lucchi, Michael Aidoo, Venkatachalam Udhayakumar, Eric Halsey, Eric Rogier
Background: Response to antimalarial treatment is assessed using serial microscopy. New techniques for accurate measurement of the Plasmodium falciparum histidine rich protein 2 (HRP2) antigen have made monitoring antigen concentration over time a potential alternative for assessing treatment response. Methods: Post-treatment HRP2 concentration was measured in longitudinal samples from 537 participants with P. falciparum malaria from efficacy trials in Angola, Tanzania, and Senegal...
December 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29220494/soapnuke-a-mapreduce-acceleration-supported-software-for-integrated-quality-control-and-preprocessing-of-high-throughput-sequencing-data
#13
Yuxin Chen, Yongsheng Chen, Chunmei Shi, Zhibo Huang, Yong Zhang, Shengkang Li, Yan Li, Jia Ye, Chang Yu, Zhuo Li, Xiuqing Zhang, Jian Wang, Huanming Yang, Lin Fang, Qiang Chen
Quality Control (QC) and preprocessing are essential steps for sequencing data analysis to ensure the accuracy of results. However, existing tools cannot provide a satisfying solution with integrated comprehensive functions, proper architectures and highly-scalable acceleration. In this article, we demonstrate SOAPnuke as a tool with abundant functions for a "QC-Preprocess-QC" workflow and MapReduce acceleration framework. Four modules with different preprocessing functions are designed for processing datasets from genomic, small RNA (sRNA), Digital Gene Expression (DGE) and metagenomic experiments respectively...
December 4, 2017: GigaScience
https://www.readbyqxmd.com/read/29220430/postoperative-outcomes-in-ustekinumab-treated-patients-undergoing-abdominal-operations-for-crohn-s-disease
#14
Amy L Lightner, Nicholas P McKenna, Chung Sang Tse, Neil Hyman, Radhika Smith, Gayane Ovsepyan, Phillip Fleshner, Kristen Crowell, Walter Koltun, Marc Ferrante, Andre D'Hoore, Nathalie Lauwers, Bram Verstockt, Antonino Spinelli, Francesca DiCandido, Laura E Raffals, Kellie L Mathis, Edward V Loftus
Introduction: Ustekinumab, a monoclonal antibody targeting interleukins-12 and -23 is used to treat adults with Crohn's disease (CD). We determined the 30-day postoperative infectious complication rate among CD patients who received ustekinumab within 12 weeks prior to an abdominal operation as compared to patients who received anti-tumor necrosis factor (TNF) agents. Methods: A retrospective chart review of adults with CD who underwent an abdominal operation between 1/1/2015 and 5/1/2017 was performed across six sites...
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29220414/detection-of-spontaneous-pulse-using-the-acceleration-signals-acquired-from-cpr-feedback-sensor-in-a-porcine-model-of-cardiac-arrest
#15
Liang Wei, Gang Chen, Zhengfei Yang, Tao Yu, Weilun Quan, Yongqin Li
BACKGROUND: Reliable detection of return of spontaneous circulation with minimal interruptions of chest compressions is part of high-quality cardiopulmonary resuscitation (CPR) and routinely done by checking pulsation of carotid arteries. However, manual palpation was time-consuming and unreliable even if performed by expert clinicians. Therefore, automated accurate pulse detection with minimal interruptions of chest compression is highly desirable during cardiac arrest especially in out-of-hospital settings...
2017: PloS One
https://www.readbyqxmd.com/read/29220411/hexahydrocurcumin-protects-against-cerebral-ischemia-reperfusion-injury-attenuates-inflammation-and-improves-antioxidant-defenses-in-a-rat-stroke-model
#16
Piyawadee Wicha, Jiraporn Tocharus, Adchara Janyou, Jinatta Jittiwat, Chatchawan Changtam, Apichart Suksamrarn, Chainarong Tocharus
The purpose of the present experiment was to investigate whether hexahydrocurcumin (HHC) attenuates brain damage and improves functional outcome via the activation of antioxidative activities, anti-inflammation, and anti-apoptosis following cerebral ischemia/reperfusion (I/R). In this study, rats with cerebral I/R injury were induced by a transient middle cerebral artery occlusion (MCAO) for 2 h, followed by reperfusion. The male Wistar rats were randomly divided into five groups, including the sham-operated, vehicle-treated, 10 mg/kg HHC-treated, 20 mg/kg HHC-treated, and 40 mg/kg HHC-treated I/R groups...
2017: PloS One
https://www.readbyqxmd.com/read/29220407/respiratory-resistance-and-reactance-in-adults-with-sickle-cell-anemia-correlation-with-functional-exercise-capacity-and-diagnostic-use
#17
Cirlene de Lima Marinho, Maria Christina Paixão Maioli, Jorge Luis Machado do Amaral, Agnaldo José Lopes, Pedro Lopes de Melo
BACKGROUND: The improvement in sickle cell anemia (SCA) care resulted in the emergence of a large population of adults living with this disease. The mechanisms of lung injury in this new population are largely unknown. The forced oscillation technique (FOT) represents the current state-of-the-art in the assessment of lung function. The present work uses the FOT to improve our knowledge about the respiratory abnormalities in SCA, evaluates the associations of FOT with the functional exercise capacity and investigates the early detection of respiratory abnormalities...
2017: PloS One
https://www.readbyqxmd.com/read/29220401/contour-recognition-of-complex-leaf-shapes
#18
Giacomo Diaz
The leaf shape is an important taxonomic character. Compared to the classic morphological leaf features such as veins, margin indentations, sinuses, etc., the shape is simpler to obtain by using the 'magic wand' or other contouring tools that are available in most of imaging applications. The only exception is when leaves develop large lobes that get in touch or overlap each other, as the presence of hidden or closed portions of the leaf border precludes the application of automatic methods and forces the leaf contour to be traced manually...
2017: PloS One
https://www.readbyqxmd.com/read/29220372/the-monomeric-form-of-neisseria-dna-mimic-protein-dmp19-prevents-dna-from-binding-to-the-histone-like-hu-protein
#19
Ming-Fen Huang, Shin-Jen Lin, Tzu-Ping Ko, Yi-Ting Liao, Kai-Cheng Hsu, Hao-Ching Wang
DNA mimicry is a direct and effective strategy by which the mimic competes with DNA for the DNA binding sites on other proteins. Until now, only about a dozen proteins have been shown to function via this strategy, including the DNA mimic protein DMP19 from Neisseria meningitides. We have shown previously that DMP19 dimer prevents the operator DNA from binding to the transcription factor NHTF. Here, we provide new evidence that DMP19 monomer can also interact with the Neisseria nucleoid-associated protein HU...
2017: PloS One
https://www.readbyqxmd.com/read/29220356/color-doppler-ultrasonography-as-an-alternative-tool-for-postoperative-evaluation-of-collaterals-after-indirect-revascularization-surgery-in-moyamoya-disease
#20
Shin-Joe Yeh, Sung-Chun Tang, Li-Kai Tsai, Chung-Wei Lee, Ya-Fang Chen, Hon-Man Liu, Shih-Hung Yang, Meng-Fai Kuo, Jiann-Shing Jeng
The cerebral hypoperfusion caused by chronic progressive stenosis or occlusion of intracranial arteries in moyamoya disease can be treated by direct bypass or indirect revascularization procedures. The extent of collaterals from the external carotid artery (ECA) after indirect revascularization surgery is the key point of angiographic follow-up, and the invasiveness of angiography impelled us to investigate the role of ultrasonography in the evaluation of collaterals. We hypothesized that the collaterals shown on angiography might produce corresponding hemodynamic changes in color Doppler ultrasonography...
2017: PloS One
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