keyword
https://read.qxmd.com/read/38547511/operating-properties-of-disease-activity-indices-in-pediatric-inflammatory-bowel-disease-a-systematic-review
#1
JOURNAL ARTICLE
Ruben J Colman, Virginia Solitano, John K MacDonald, Christopher Ma, Anne M Griffiths, Vipul Jairath, Eileen Crowley
BACKGROUND: Accurate, reliable, and responsive disease activity indices are important to streamline drug approval and treatment modalities for pediatric inflammatory bowel disease (pIBD). We aimed to identify all scoring indices used in pIBD randomized controlled trials (RCTs) and to evaluate their operating properties. METHODS: MEDLINE, EMBASE, and CENTRAL were searched on December 6, 2022, to identify studies evaluating clinical, endoscopic, imaging, or patient-reported outcome measures (PROMs) in pIBD including Crohn's disease (CD) and ulcerative colitis (UC)...
March 28, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38547508/comparison-of-polytech-mesmo-and-motiva-ergonomix-breast-implants-with-a-focus-on-displacement-issues-a-single-surgeon-s-experience-in-329-patients
#2
JOURNAL ARTICLE
Paolo Montemurro
BACKGROUND: Nanotextured breast implants (classified as smooth implants by the latest ISO 14607:2018) have been described as they may reduce major textured implant-related complications such as capsular contracture and breast implant-associated anaplastic large cell lymphoma. On the other hand, micro-textured breast implants benefit from an optimal safety profile based on a much larger body of literature. OBJECTIVES: To directly compare the incidence of complications between Motiva Ergonomix (Establishment Labs, Alajuela, Costa Rica) and Polytech MESMO (Polytech Health & Aesthetics GmbH, Dieburg, Germany) breast implants, especially regarding the displacement issues that might arise after breast augmentation...
March 28, 2024: Aesthetic Surgery Journal
https://read.qxmd.com/read/38547497/evaluating-chatgpt-4-0-s-data-analytic-proficiency-in-epidemiological-studies-a-comparative-analysis-with-sas-spss-and-r
#3
JOURNAL ARTICLE
Yeen Huang, Ruipeng Wu, Juntao He, Yingping Xiang
BACKGROUND: OpenAI's Chat Generative Pre-trained Transformer 4.0 (ChatGPT-4), an emerging artificial intelligence (AI)-based large language model (LLM), has been receiving increasing attention from the medical research community for its innovative 'Data Analyst' feature. We aimed to compare the capabilities of ChatGPT-4 against traditional biostatistical software (i.e. SAS, SPSS, R) in statistically analysing epidemiological research data. METHODS: We used a data set from the China Health and Nutrition Survey, comprising 9317 participants and 29 variables (e...
March 29, 2024: Journal of Global Health
https://read.qxmd.com/read/38547433/are-metal-ion-levels-elevated-after-dual-mobility-acetabular-systems-minimum-five-year-analyses
#4
JOURNAL ARTICLE
Daniel Hameed, Jeremy Dubin, Zhongming Chen, Nipun Sodhi, Michael A Mont, Steven F Harwin
INTRODUCTION: While dual mobility systems in total hip replacements have demonstrated reduced dislocation and revision occurrences, concerns persist about the potential elevation of metal ions in the bloodstream, leading to negative tissue reactions. Notably, there's a scarcity of research spanning over five years post-surgery that examines cobalt and chromium levels after such implants. This study aimed to delve into these metal ion concentrations after a five-year period, building on previous metal-ion findings...
March 7, 2024: Surgical Technology International
https://read.qxmd.com/read/38547432/true-confessions-of-neutral-mechanical-disciple-how-i-learned-to-love-a-patient-specific-target
#5
JOURNAL ARTICLE
Nathalie Willems, Kevin B Marchand, Christina Esposito, Daniele De Massari, Daniel Hameed, Gavin Clark, Robert Marchand, Michael A Mont, Michael Dunbar
INTRODUCTION: Classical neutral mechanical alignment in total knee arthroplasty (TKA) has been a standard paradigm, while more recently, other alignment schemas, such as kinematic, individualized, and functional, have been explored. This study aimed to investigate the effect of three-dimensional (3D) computed tomography (CT)-based surgical robotics inputs on a classically trained surgeon's TKA component positions and alignment targets over time. MATERIALS AND METHODS: Data from 1,394 consecutive robotically-assisted TKAs by a single surgeon from 2016 to 2020 were analyzed...
March 7, 2024: Surgical Technology International
https://read.qxmd.com/read/38547420/pyroptosis-derived-long-noncoding-rna-profiles-reveal-a-novel-signature-for-evaluating-the-prognosis-of-patients-with-lung-adenocarcinoma
#6
JOURNAL ARTICLE
Yuhao Ba, Shutong Liu, Zhengpan Wei, Nannan Zhao, Tong Qiao, Yuqing Ren, Lifeng Li, Yuyuan Zhang, Siyuan Weng, Hui Xu, Chunwei Li, Xiaoyong Ge, Xinwei Han
PURPOSE: Long noncoding RNAs (lncRNAs) were recently implicated in modifying pyroptosis. Nonetheless, pyroptosis-related lncRNAs and their possible clinical relevance persist largely uninvestigated in lung adenocarcinoma (LUAD). MATERIALS AND METHODS: A sum of 921 samples were collected from three independent data sets. We obtained pyroptosis-related genes from both the Molecular Signatures Database and relevant literature sources and used four machine learning techniques, comprising stepwise Cox, ridge regression, least absolute shrinkage and selection operator, and random forest...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38547416/characterizing-barriers-and-facilitators-of-metabolic-bariatric-surgery-tourism-a-systematic-review
#7
JOURNAL ARTICLE
Sharukh Zuberi, Abdullah Egiz, Hasan Iqbal, Periyathambi Jambulingam, Douglas Whitelaw, Tanveer Adil, Vigyan Jain, Omar Al-Taan, Aruna Munasinghe, Alan Askari, Mohamed K Aly, Fahad M Iqbal
BACKGROUND: Metabolic bariatric surgery tourism continues to rise and has become a growing concern for bariatric surgeons globally. With varying degrees of regulation, counselling and success, those that develop complications may have to deal with a multitude of challenges often distant from their country of operation. The aim of this study was to characterize the barriers and facilitators influencing individuals to undergo metabolic bariatric surgery tourism, in order to better understand the implications to the National Health Service and other healthcare systems...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38547415/an-overview-of-research-for-the-application-of-a-novel-biofilm-preventing-surgical-irrigation-system-for-total-joint-arthroplasty-procedures-in-order-to-reduce-the-risk-of-periprosthetic-infection
#8
JOURNAL ARTICLE
Sean B Sequeira, Matthew F Myntti, Jeanne Lee, Michael A Mont
Periprosthetic joint infection (PJI) is a serious postoperative complication in joint arthroplasty procedures that carries substantial morbidity and mortality associated with it. Several strategies have been developed both in the preoperative, perioperative, and postoperative periods to both combat and prevent the development of this devastating complication. Intraoperative irrigation is an important modality used during arthroplasty procedures prior to the implantation of final components that seeks to eradicate any biofilm formation...
March 28, 2024: Surgical Technology International
https://read.qxmd.com/read/38547413/telemedicine-for-potential-application-in-austere-military-environments-neurosurgical-support-for-a-decompressive-craniectomy
#9
JOURNAL ARTICLE
Pieter W Stark, O J F van Waes, John S Soria van Hoeve, Boudewijn L S Borger van der Burg, Rigo Hoencamp
INTRODUCTION: The main goal of this study was to assess the feasibility of a head-mounted display (HMD) providing telemedicine neurosurgical support during a decompressive craniectomy by a military surgeon who is isolated from readily available neurosurgical care. The secondary aim was to assess the usability perceived by the military surgeon and to evaluate technical aspects of the head-mounted display. MATERIALS AND METHODS: After a standard concise lecture, 10 military surgeons performed a decompressive craniectomy on a AnubiFiX-embalmed post-mortem human head...
March 28, 2024: Military Medicine
https://read.qxmd.com/read/38547410/the-science-of-stapling-staple-form
#10
JOURNAL ARTICLE
Prachi Rojatkar, Anil K Nalagatla, Crystal D Ricketts, Jeffrey W Clymer, Emily Yosh
Surgical stapling has evolved significantly over time, with the primary goal of improving patient outcomes. This study describes the technological advancements in surgical stapling from the perspective of staple and cartridge design, assessing the impact of staple design when it changes from the traditional B form (also known as 2D staple form) to a three-dimensional form (known as 3D staple form). The change in configuration helps compress a larger surface area of the tissue. The 3D configuration is designed to optimize compression not only underneath each staple but also across staples and multiple staple lines, including both stapled and unstapled regions of the tissue...
March 19, 2024: Surgical Technology International
https://read.qxmd.com/read/38547393/uniportal-video-assisted-thoracic-surgery-segmentectomy-versus-lobectomy-early-outcomes
#11
JOURNAL ARTICLE
Erik Sachs, Veronica Jackson, Mamdoh Al-Ameri, Ulrik Sartipy
OBJECTIVES: To assess the feasibility and safety of uniportal video-assisted thoracoscopic pulmonary segmentectomy compared with lobectomy by studying early postoperative outcomes. METHODS: We included all patients who underwent uniportal segmentectomy and lobectomy between 2017 and 2022 at Karolinska University Hospital. Early clinical outcomes were compared between the uniportal segmentectomy and lobectomy groups. Differences in baseline characteristics were addressed using inverse probability of treatment weighting...
March 28, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38547379/quantifying-f%C3%A3-rster-resonance-energy-transfer-from-single-perovskite-quantum-dots-to-organic-dyes
#12
JOURNAL ARTICLE
Leon G Feld, Simon C Boehme, Viktoriia Morad, Yesim Sahin, Christoph J Kaul, Dmitry N Dirin, Gabriele Rainò, Maksym V Kovalenko
Colloidal quantum dots (QDs) are promising regenerable photoredox catalysts offering broadly tunable redox potentials along with high absorption coefficients. QDs have thus far been examined for various organic transformations, water splitting, and CO2 reduction. Vast opportunities emerge from coupling QDs with other homogeneous catalysts, such as transition metal complexes or organic dyes, into hybrid nanoassemblies exploiting energy transfer (ET), leveraging a large absorption cross-section of QDs and long-lived triplet states of cocatalysts...
March 28, 2024: ACS Nano
https://read.qxmd.com/read/38547326/copper-catalyzed-radical-relay-1-3-carbocarbonylation-across-two-distinct-c%C3%A2-c-bonds
#13
JOURNAL ARTICLE
Nan-Nan Dai, Yue-Jiao Lu, Zhong-Qi Wu, Yu Zhou, Ying Tong, Keqi Tang, Qiang Li, Jun-Qi Zhang, Yu Liu, Wen-Ting Wei
The radical relay provides an effective paradigm for intermolecular assembly to achieve functionalization across remote chemical bonds. Herein, we report the first radical relay 1,3-carbocarbonylation of α-carbonyl alkyl bromides across two separate C═C bonds. The reaction is highly chemo- and regioselective, with two C(sp3 )-C(sp3 ) bonds and one C═O bond formed in a single orchestrated operation. In addition, the synthesis method under mild conditions and using inexpensive copper as the catalyst allows facile access to structurally diverse 1,3-carbocarbonylation products...
March 28, 2024: Organic Letters
https://read.qxmd.com/read/38547272/ai-in-africa-basics-over-buzz
#14
EDITORIAL
Rose M Mutiso
When Buti Manamela visited Lengau, Africa's fastest supercomputer, he had more prosaic technology in mind: electricity. South Africa's Deputy Minister of Higher Education, Science and Technology was at the Center for High Performance Computing in Cape Town for what should have been a showcase tour of a facility providing the country with the computing power needed to run and analyze the kinds of complex models and huge datasets that underpin artificial intelligence (AI) and machine learning (ML). But Manamela was there to better understand the impact of South Africa's rolling power blackouts on the center's operations...
March 29, 2024: Science
https://read.qxmd.com/read/38547258/qbnb-an-innovative-c2b2c2b2c-e-commerce-mode-for-integrated-on-demand-services
#15
JOURNAL ARTICLE
Yaoyao Wei, Cuiyin Yao, Wei-Fan Chen, Tian Xie, Jinzhao Yang
The traditional supply-side-driven e-commerce modes provide consumers with massive amounts of structured information about goods and services. Due to the lack of a tailor-made ability to describe, explain, and accurately understand unstructured service demands, existing technologies and service modes still struggle to fully explore, articulate, and meet the personalized, high-quality, and urgent service demands of the disadvantaged groups in e-commerce. This paper innovatively proposes the concept of "integrated services on demand" and develops its C2B2C2B2C-based "Qbnb" e-commerce mode, operation mechanism and intermediary platform architecture...
2024: PloS One
https://read.qxmd.com/read/38547231/compact-rover-surveying-and-laser-scanning-for-bim-development
#16
JOURNAL ARTICLE
Syed Riaz Un Nabi Jafri, Syed Murtaza Hussain, Asif Ahmed, Syed Asher Hussain Rizvi, Kumayl Hassan Kazmi, Jamshed Iqbal
This paper presents a custom made small rover based surveying, mapping and building information modeling solution. Majority of the commercially available mobile surveying systems are larger in size which restricts their maneuverability in the targeted indoor vicinities. Furthermore their functional cost is unaffordable for low budget projects belonging to developing markets. Keeping in view these challenges, an economical indigenous rover based scanning and mapping system has developed using orthogonal integration of two low cost RPLidar A1 laser scanners...
2024: PloS One
https://read.qxmd.com/read/38547215/national-clinical-and-financial-outcomes-associated-with-acute-kidney-injury-following-esophagectomy-for-cancer
#17
JOURNAL ARTICLE
Ayesha P Ng, Nikhil Chervu, Corynn Branche, Syed Shahyan Bakhtiyar, Mehrab Marzban, Paul A Toste, Peyman Benharash
BACKGROUND: Esophagectomy is a complex oncologic operation associated with high rates of postoperative complications. While respiratory and septic complications have been well-defined, the implications of acute kidney injury (AKI) remain unclear. Using a nationally representative database, we aimed to characterize the association of AKI with mortality, resource use, and 30-day readmission. METHODS: All adults undergoing elective esophagectomy with a diagnosis of esophageal or gastric cancer were identified in the 2010-2019 Nationwide Readmissions Database...
2024: PloS One
https://read.qxmd.com/read/38547199/prognostic-accuracy-of-early-warning-scores-for-predicting-serious-illness-and-in-hospital-mortality-in-patients-with-covid-19
#18
JOURNAL ARTICLE
Mehnaz Kamal, S M Tafsir Hasan, Monira Sarmin, Subhasish Das, Lubaba Shahrin, A S G Faruque, Mohammod Jobayer Chisti, Tahmeed Ahmed
A simple bedside triage tool is essential to stratify COVID-19 patients in the emergency department (ED). This study aimed to identify an early warning score (EWS) that could best predict the clinical outcomes in COVID-19 patients. Data were obtained from medical records of 219 laboratory-confirmed COVID-19 positive patients. We calculated 13 EWSs based on the admission characteristics of the patients. Receiver operating characteristic (ROC) curve analysis was used to assess the performance of the scores in predicting serious illness and in-hospital mortality...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547197/selection-of-presale-models-for-innovative-products-considering-channel-preferences-and-valuation-differences
#19
JOURNAL ARTICLE
Manman Jiang, Liping Qin, Wenjin Zuo, Qiang Hu
To reduce financial pressure and operational risk, and improve match between supply and demand, an increasing number of enterprises are adopting presales to launch new products. In this context, this paper investigates three presale models for innovative products, namely, the no-presale model, the manufacturer presale model and the retailer presale model. A Hotelling model is used to describe the impact of channel preferences and valuation differences on the two-stage competition between innovative products...
2024: PloS One
https://read.qxmd.com/read/38547151/institutional-investors-site-visits-and-investment-cash-flow-sensitivity-mitigating-financing-constraints-or-inhibiting-agent-conflicts
#20
JOURNAL ARTICLE
Jia Liao, Yun Zhan, Yu Yuan
Taking Chinese non-financial A-share companies listed on the Shenzhen Stock Exchange (SZSE) between 2003 and 2018 as a sample, this paper empirically examines whether and how institutional investors' site visits (SVs) affect corporate investment-cash flow sensitivity (ICFS). The results show that institutional investors' SVs can reduce ICFS, and this effect is more obvious for companies with fewer investment opportunities, larger sizes, higher internal cash flows, and higher agency costs, indicating that institutional investors' SVs primarily inhibit ICFS caused by agency conflicts rather than financing constraints...
2024: PloS One
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