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https://www.readbyqxmd.com/read/28230828/chromosomal-mutagenesis-in-human-somatic-cells-30-year-cytogenetic-monitoring-after-chornobyl-accident
#1
M A Pilinska, G M Shemetun, O V Shemetun, S S Dybsky, O B Dybska, O O Talan, L R Pedan, D А Kurinnyi
In the lecture we have generalized and analyzed the data of cytogenetic laboratory of National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine on 30-year selective cytogenetic monitoring among the priority contingents of different ages exposed to radiation after Chornobyl accident in Ukraine. It is highlighted that not only targeted but also untargeted radiation-induced cytogenetic effects should be explored, especially in delayed terms following radiation exposure...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28228742/sleep-dependent-consolidation-of-rewarded-behavior-is-diminished-in-children-with-attention-deficit-hyperactivity-disorder-and-a-comorbid-disorder-of-social-behavior
#2
Christian D Wiesner, Ina Molzow, Alexander Prehn-Kristensen, Lioba Baving
Children suffering from attention-deficit hyperactivity disorder (ADHD) often also display impaired learning and memory. Previous research has documented aberrant reward processing in ADHD as well as impaired sleep-dependent consolidation of declarative memory. We investigated whether sleep also fosters the consolidation of behavior learned by probabilistic reward and whether ADHD patients with a comorbid disorder of social behavior show deficits in this memory domain, too. A group of 17 ADHD patients with comorbid disorders of social behavior aged 8-12 years and healthy controls matched for age, IQ, and handedness took part in the experiment...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28223921/epigenetic-modulation-of-stem-cells-in-neurodevelopment-the-role-of-methylation-and-acetylation
#3
REVIEW
Martyna Podobinska, Ilona Szablowska-Gadomska, Justyna Augustyniak, Ioanna Sandvig, Axel Sandvig, Leonora Buzanska
The coordinated development of the nervous system requires fidelity in the expression of specific genes determining the different neural cell phenotypes. Stem cell fate decisions during neurodevelopment are strictly correlated with their epigenetic status. The epigenetic regulatory processes, such as DNA methylation and histone modifications discussed in this review article, may impact both neural stem cell (NSC) self-renewal and differentiation and thus play an important role in neurodevelopment. At the same time, stem cell decisions regarding fate commitment and differentiation are highly dependent on the temporospatial expression of specific genes contingent on the developmental stage of the nervous system...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28222846/planning-for-the-leicester-city-football-club-victory-parade
#4
Martin Halse
This paper details the multiagency planning for and delivery of the Leicester City Football Club victory parade at the end of the 2015/16 football season to celebrate the team winning the Barclays Premier League. This is compared and contrasted with the planning and delivery of the reinterment of the mortal remains of King Richard III, which took place in Leicester a little more than 12 months prior. Both events were unprecedentedly high-profile for a comparatively small city and the routes involved had much in common...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#5
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28221237/ptsd-orientation-to-pain-and-pain-perception-in-ex-prisoners-of-war-who-underwent-torture
#6
Noga Tsur, Ruth Defrin, Karni Ginzburg
OBJECTIVE: Studies suggest that torture survivors often suffer long-term chronic pain and increased pain perception. However, it is unclear whether the actual experience of torture, or rather the subsequent posttraumatic stress disorder (PTSD), explains these pain problems. Furthermore, while catastrophic and fearful orientations to pain have been suggested to play a significant role in the association between trauma and pain, the underlying mechanisms remain unclear. This study examined whether chronic pain and pain perception among torture survivors are associated with torture experience or PTSD and whether catastrophic and fearful orientations mediate or moderate these associations...
February 17, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28220477/parent-child-learning-interactions-a-review-of-the-literature-on-scaffolding
#7
Roni Mermelshtine
BACKGROUND: Scaffolding can be observed during learning-based interactions, when interventions by parents are adjusted according to children's observed abilities, with the main goal of enabling the child to work independently (Wood et al., 1976, Journal of child psychology and psychiatry, 17, 89). Such contingent instruction behaviours occur from infancy, and are said to be relevant for children's development of executive function, language acquisition, and cognitive and academic abilities...
February 21, 2017: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/28220334/future-directions-in-personality-occupational-and-medical-selection-myths-misunderstandings-measurement-and-suggestions
#8
Eamonn Ferguson, Filip Lievens
This paper has two objectives: (1) presenting recent advances in personality theory whereby personality traits are conceptualized within a framework that focuses on the dynamic interactions of behaviour, biology, context, and states, and (2) discussing the implications of these developments for measurement and medical selection. We start by presenting evidence that traits are no longer regarded as stable deterministic predictors of behaviour. Instead, traits are found to change across generations, the life span, and in response to environmental contingencies...
February 20, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28219972/venomics-integrative-venom-proteomics-and-beyond
#9
REVIEW
Juan J Calvete
Venoms are integrated phenotypes that evolved independently in, and are used for predatory and defensive purposes by, a wide phylogenetic range of organisms. The same principles that contribute to the evolutionary success of venoms, contribute to making the study of venoms of great interest in such diverse fields as evolutionary ecology and biotechnology. Evolution is profoundly contingent, and nature also reinvents itself continuosly. Changes in a complex phenotypic trait, such as venom, reflect the influences of prior evolutionary history, chance events, and selection...
February 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28216120/no-impact-of-repeated-extinction-exposures-on-operant-responding-maintained-by-different-reinforcer-rates
#10
John Y H Bai, Christopher A Podlesnik
Greater rates of intermittent reinforcement in the presence of discriminative stimuli generally produce greater resistance to extinction, consistent with predictions of behavioral momentum theory. Other studies reveal more rapid extinction with higher rates of reinforcers - the partial reinforcement extinction effect. Further, repeated extinction often produces more rapid decreases in operant responding due to learning a discrimination between training and extinction contingencies. The present study examined extinction repeatedly with training with different rates of intermittent reinforcement in a multiple schedule...
February 16, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28215184/modes-of-relating-to-contingency-an-exploration-of-experiences-in-advanced-cancer-patients-erratum
#11
Renske Kruizinga, Iris D Hartog, Michael Scherer-Rath, Hans Schilderman, Hanneke Van Laarhoven
No abstract text is available yet for this article.
February 20, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28214661/contingent-self-worth-moderates-the-relationship-between-school-stressors-and-psychological-stress-responses
#12
Kenichiro Ishizu
This study examined the moderating role of contingent self-worth on the relationships between school stressors and psychological stress responses among Japanese adolescents. A total of 371 Japanese junior high school students (184 boys and 187 girls, Mage = 12.79 years, SD = 0.71) completed the Japanese version of the Self-Worth Contingency Questionnaire and a mental health checklist at two points separated by a two-month interval. Hierarchical multiple regression analyses were then used to determine whether contingent self-worth moderated the relationship between school stressors and psychological stress responses...
February 16, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28212966/estimating-preferences-for-complex-health-technologies-lessons-learned-and-implications-for-personalized-medicine
#13
Deborah A Marshall, Juan Marcos Gonzalez, Karen V MacDonald, F Reed Johnson
We examine key study design challenges of using stated-preference methods to estimate the value of whole-genome sequencing (WGS) as a specific example of genomic testing. Assessing the value of WGS is complex because WGS provides multiple findings, some of which can be incidental in nature and unrelated to the specific health concerns that motivated the test. In addition, WGS results can include actionable findings (variants considered to be clinically useful and can be acted on), findings for which evidence for best clinical action is not available (variants considered clinically valid but do not meet as high of a standard for clinical usefulness), and findings of unknown significance...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212470/-prediabetes-as-a-riskmarker-for-stress-induced-hyperglycemia-in-critically-ill-adults
#14
Diego Jesús García-Gallegos, Eliseo Luis-López
BACKGROUND: It is not known if patients with prediabetes, a subgroup of non-diabetic patients that usually present hyperinsulinemia, have higher risk to present stress-induced hyperglycemia. The objective was to determine if prediabetes is a risk marker to present stress-induced hyperglycemia. METHODS: Analytic, observational, prospective cohort study of non-diabetic critically ill patients of a third level hospital. We determined plasmatic glucose and glycated hemoglobin (HbA1c) at admission to diagnose stress-induced hyperglycemia (glucose ≥ 140 mg/dL) and prediabetes (HbA1c between 5...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28212065/children-s-knowledge-of-genital-anatomy-and-its-relationship-with-children-s-use-of-the-word-inside-during-questioning-about-possible-sexual-abuse
#15
Lisa J Milam, William R Nugent
This study was designed to examine the relationship between children's understanding of their genital anatomy and their use of the word "inside" in response to questions about genital touch during a forensic medical examination. This study involved a secondary data analysis of 674 records of children at a sexual abuse clinic in a large city in a southern state. Data were analyzed using contingency table, binary logistic, and multinomial logistic regression analysis methods. An association between children's understanding of genital anatomy and their use of the word "inside" to describe genital touch was found...
January 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28211949/internet-based-self-tailored-deposit-contracts-to-promote-smoking-reduction-and-abstinence
#16
Brantley P Jarvis, Jesse Dallery
Deposit contracting may reduce costs and increase efficacy in contingency management interventions. We evaluated two Internet-based deposit contract arrangements for smoking. In Experiment 1, nine participants deposited self-selected amounts that could be earned back for meeting goals. During treatment, participants were reimbursed for breath samples with less than or equal to 6 parts per million carbon monoxide and met the criterion for 47% of samples compared to 1% during baseline. In Experiment 2, 10 participants' deposits were matched up to $50...
February 17, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28207777/quantifying-the-value-of-perfect-information-in-emergency-vaccination-campaigns
#17
Naomi V Bradbury, William J M Probert, Katriona Shea, Michael C Runge, Christopher J Fonnesbeck, Matt J Keeling, Matthew J Ferrari, Michael J Tildesley
Foot-and-mouth disease outbreaks in non-endemic countries can lead to large economic costs and livestock losses but the use of vaccination has been contentious, partly due to uncertainty about emergency FMD vaccination. Value of information methods can be applied to disease outbreak problems such as FMD in order to investigate the performance improvement from resolving uncertainties. Here we calculate the expected value of resolving uncertainty about vaccine efficacy, time delay to immunity after vaccination and daily vaccination capacity for a hypothetical FMD outbreak in the UK...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28205448/association-between-red-meat-consumption-and-colon-cancer-a-systematic-review-of-experimental-results
#18
Nancy D Turner, Shannon K Lloyd
A role for red and processed meat in the development of colorectal cancer has been proposed based largely on evidence from observational studies in humans, especially in those populations consuming a westernized diet. Determination of causation specifically by red or processed meat is contingent upon identification of plausible mechanisms that lead to colorectal cancer. We conducted a systematic review of the available evidence to determine the availability of plausible mechanistic data linking red and processed meat consumption to colorectal cancer risk...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28201925/interdependent-group-contingencies-decrease-adolescents-disruptive-behaviors-during-group-therapy
#19
Kristen M Brogan, John Michael Falligant, John T Rapp
Adolescents who have been adjudicated for illegal sexual behavior may receive treatment that requires attending group therapy sessions and classes. For some adolescents, nonsexual problem behavior (e.g., verbal outbursts, noncompliance) interferes with their ability to participate in group treatment. Researchers used a multiple-baseline across groups design with an embedded changing criterion design to evaluate the effects of an interdependent group contingency for decreasing disruptive behavior in adolescents across two therapy groups...
February 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28199405/co-financing-for-viral-load-monitoring-during-the-course-of-antiretroviral-therapy-among-patients-with-hiv-aids-in-vietnam-a-contingent-valuation-survey
#20
Quyen Le Thi Nguyen, Long Hoang Nguyen, Bach Xuan Tran, Huong Thi Thu Phan, Huong Thi Le, Hinh Duc Nguyen, Tho Dinh Tran, Cuong Duy Do, Cuong Manh Nguyen, Vu Thi Minh Thuc, Carl Latkin, Melvyn W B Zhang, Roger C M Ho
BACKGROUND: Viral load testing is considered the gold standard for monitoring HIV treatment; however, given its high cost, some patients cannot afford viral load testing if this testing is not subsidized. Since foreign aid for HIV/AIDS in Vietnam is rapidly decreasing, we sought to assess willingness to pay (WTP) for viral load and CD4 cell count tests among HIV-positive patients, and identified factors that might inform future co-payment schemes. METHODS: A multi-site cross-sectional survey was conducted with 1133 HIV-positive patients on antiretroviral therapy (ART) in Hanoi and Nam Dinh...
2017: PloS One
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