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Reinforcers

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https://www.readbyqxmd.com/read/28732317/cross-lagged-relations-between-motives-and-substance-use-can-use-strengthen-your-motivation-over-time
#1
Christine A Lee, Karen J Derefinko, Heather A Davis, Richard Milich, Donald R Lynam
Motives for substance use have garnered considerable attention due to the strong predictive utility of this construct, both in terms of use and problems associated with use. The current study examined the cross-lagged relations between alcohol use and motives, and marijuana use and motives over three yearly assessment periods in a large sample (N=526, 48% male) of college students. The relations between substance use and motives were assessed at each time point, allowing for the examination of these inter-relations over time...
June 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28732247/repairing-sciatic-nerve-injury-with-an-epo-loaded-nerve-conduit-and-sandwiched-in-strategy-of-transplanting-mesenchymal-stem-cells
#2
Wei Zhang, Lihai Zhang, Jianheng Liu, Licheng Zhang, Jian Zhang, Peifu Tang
Transplantation of a biosynthetic nerve conduit carrying neuro-protective cytokines is promising for treating peripheral nerve injury. Here we developed a novel strategy for repairing sciatic nerve injury by EPO-loaded Chitosan nerve conduit (EPO/Chi) and sandwiched-in transplantation of mesenchymal stem cells (MSCs). Then, the beneficial effect of EPO/Chi + MSCs on nerve regeneration was also further investigated by in vitro cellular experiments. In vivo experiment showed that combination of EPO-loaded Chitosan nerve conduit with MSCs could significantly accelerate nerve healing and improve morphological repair...
July 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28732231/kernel-dynamic-policy-programming-applicable-reinforcement-learning-to-robot-systems-with-high-dimensional-states
#3
Yunduan Cui, Takamitsu Matsubara, Kenji Sugimoto
We propose a new value function approach for model-free reinforcement learning in Markov decision processes involving high dimensional states that addresses the issues of brittleness and intractable computational complexity, therefore rendering the value function approach based reinforcement learning algorithms applicable to high dimensional systems. Our new algorithm, Kernel Dynamic Policy Programming (KDPP) smoothly updates the value function in accordance to the Kullback-Leibler divergence between current and updated policies...
June 29, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28732152/secukinumab-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-a-review-of-the-literature
#4
M Abrouk, J Gandy, M Nakamura, K Lee, M Brodsky, R Singh, H Zhu, B Farahnik, T Bhutani, J Koo
While there are several commercially available treatment options for psoriasis and psoriatic arthritis, there remains a large number of individuals who are refractory to current modalities. In the recent past, there has been increasing evidence that interleukin (IL)-17 plays a vital role in the pathophysiology of psoriasis. Preclinical, phase II, and phase III studies of secukinumab (Cosentyx®) targeting IL-17 and its receptor have thus far proved to be promising. We reviewed the results of phase II and phase III clinical trials for secukinumab in the treatment of psoriasis and psoriatic arthritis...
July 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28732104/reciprocal-feedback-between-self-concept-and-goal-pursuit-in-daily-life
#5
Alexander E Wong, Robin R Vallacher
OBJECTIVE: We hypothesized that self-knowledge and goal-perseverance are mutually reinforcing because of the roles of self-knowledge in directing goal pursuit, and of goal pursuit in structuring the self-concept. METHOD: To test this hypothesis, we used a daily diary design with 97 college-aged participants for 40 days to assess whether daily self-concept clarity and grit predict one another's next day levels. Data were analyzed using multilevel cross-lagged panel modeling...
July 21, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28732032/individual-and-area-level-characteristics-associated-with-alcohol-related-mortality-among-adult-lithuanian-males-a-multilevel-analysis-based-on-census-linked-data
#6
Pavel Grigoriev, Domantas Jasilionis, Daumantas Stumbrys, Vladislava Stankūnienė, Vladimir M Shkolnikov
BACKGROUND: Although excessive alcohol-related mortality in the post-Soviet countries remains the major public health threat, determinants of this phenomenon are still poorly understood. AIMS: We assess simultaneously individual- and area-level factors associated with an elevated risk of alcohol-related mortality among Lithuanian males aged 30-64. METHODS: Our analysis is based on a census-linked dataset containing information on individual- and area-level characteristics and death events which occurred between March 1st, 2011 and December 31st, 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28732006/drivers-for-rift-valley-fever-emergence-in-mayotte-a-bayesian-modelling-approach
#7
Raphaëlle Métras, Guillaume Fournié, Laure Dommergues, Anton Camacho, Lisa Cavalerie, Philippe Mérot, Matt J Keeling, Catherine Cêtre-Sossah, Eric Cardinale, W John Edmunds
Rift Valley fever (RVF) is a major zoonotic and arboviral hemorrhagic fever. The conditions leading to RVF epidemics are still unclear, and the relative role of climatic and anthropogenic factors may vary between ecosystems. Here, we estimate the most likely scenario that led to RVF emergence on the island of Mayotte, following the 2006-2007 African epidemic. We developed the first mathematical model for RVF that accounts for climate, animal imports and livestock susceptibility, which is fitted to a 12-years dataset...
July 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28731982/peripheral-oxytocin-receptors-inhibit-the-nociceptive-input-signal-to-spinal-dorsal-horn-wide-dynamic-range-neurons
#8
Abimael González-Hernández, Alfredo Manzano-García, Guadalupe Martínez-Lorenzana, Irma A Tello-García, Martha Carranza, Carlos Arámburo, Miguel Condés-Lara
Oxytocin has emerged as a mediator of endogenous analgesia in behavioral and electrophysiological experiments. In fact, oxytocin receptors (OTRs) in the spinal dorsal horn participate in a selective inhibition of the neuronal activity mediated by Aδ- and C-fibers but not Aβ-fibers. This study shows that OTRs are expressed in the terminal nerve endings and are able to inhibit nociceptive neuronal firing. Indeed, local peripheral oxytocin blocked the first sensorial activity Aδ- and C-fibers recorded in the spinal cord neurons...
July 19, 2017: Pain
https://www.readbyqxmd.com/read/28731964/the-relationship-between-environmental-sound-awareness-and-speech-recognition-skills-in-experienced-cochlear-implant-users
#9
Michael S Harris, Lauren Boyce, David B Pisoni, Valeriy Shafiro, Aaron C Moberly
HYPOTHESIS: 1) Environmental sound awareness (ESA) and speech recognition skills in experienced, adult cochlear implant (CI) users will be highly correlated, and, 2) ESA skills of CI users will be significantly lower than those of age-matched adults with normal hearing. BACKGROUND: Enhancement of ESA is often discussed with patients with sensorineural hearing loss as a potential benefit of implantation and, in some cases, ESA may be a major motivating factor. Despite its ecological validity and patients' expectations, ESA remains largely a presumed skill...
July 20, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28731936/case-series-keratolimbal-allograft-as-a-patch-graft-for-glaucoma-drainage-devices
#10
Sarah F Ahmed, Mason Schmutz, Sameh Mosaed
PURPOSE: Tube exposure remains one of the most common complications after glaucoma drainage device (GDD) implantation, despite various types of patch grafts available today. We present a 4 patient case series following the effectivity of the keratolimbal allograft (KLAL) as a patch graft for cases of tube exposure. Given its inherent population of stem cells, our hypothesis was that this highly replicative, biological tissue would provide an adequate means of glaucoma tube coverage. The subset of patients chosen for the KLAL patch graft all had a history of abnormally scarred conjunctiva or thin sclera...
July 20, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28731839/cost-benefit-arbitration-between-multiple-reinforcement-learning-systems
#11
Wouter Kool, Samuel J Gershman, Fiery A Cushman
Human behavior is sometimes determined by habit and other times by goal-directed planning. Modern reinforcement-learning theories formalize this distinction as a competition between a computationally cheap but inaccurate model-free system that gives rise to habits and a computationally expensive but accurate model-based system that implements planning. It is unclear, however, how people choose to allocate control between these systems. Here, we propose that arbitration occurs by comparing each system's task-specific costs and benefits...
July 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28731580/rewiring-the-glucose-transportation-and-central-metabolic-pathways-for-overproduction-of-n-acetylglucosamine-in-bacillus-subtilis
#12
Yang Gu, Jieying Deng, Yanfeng Liu, Jianghua Li, Hyun-Dong Shin, Guocheng Du, Jian Chen, Long Liu
N-acetylglucosamine (GlcNAc) is an important amino sugar extensively used in the healthcare field. in a previous study, we constructed the recombinant Bacillus subtilis strain BSGN6-PxylA -glmS-pP43NMK-GNA1 (BN0-GNA1) for microbial production of GlcNAc by pathway design and modular optimization. Here, we further improved the production of GlcNAc by rewiring both the glucose transportation and central metabolic pathways. First, the phosphotransferase system (PTS) was blocked by deletion of three genes, yyzE (encoding the PTS system transporter subunit iiA YyzE), ypqE (encoding the PTS system transporter subunit iiA YpqE), and ptsG (encoding the PTS system glucose-specific EiiCBA component), resulting in 47...
July 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28731285/plant-infection-by-two-different-viruses-induce-contrasting-changes-of-vectors-fitness-and-behavior
#13
Quentin Chesnais, Aude Couty, Maryline Uzest, Véronique Brault, Arnaud Ameline
Insect-vectored plant viruses can induce changes in plant phenotypes, thus influencing plant-vector interactions in a way that may promote their dispersal according to their mode of transmission (i.e. circulative vs. non-circulative). This indirect vector manipulation requires host-virus-vector co-evolution and would thus be effective solely in very specific plant-virus-vector species associations. Some studies suggest this manipulation may depend on multiple factors relative to various intrinsic characteristics of vectors such as transmission efficiency...
July 21, 2017: Insect Science
https://www.readbyqxmd.com/read/28730159/antibiotic-prescribing-for-adults-hospitalized-in-the-etiology-of-pneumonia-in-the-community-study
#14
Sara Tomczyk, Seema Jain, Anna M Bramley, Wesley H Self, Evan J Anderson, Chris Trabue, D Mark Courtney, Carlos G Grijalva, Grant W Waterer, Kathryn M Edwards, Richard G Wunderink, Lauri A Hicks
BACKGROUND: Community-acquired pneumonia (CAP) 2007 guidelines from the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) recommend a respiratory fluoroquinolone or beta-lactam plus macrolide as first-line antibiotics for adults hospitalized with CAP. Few studies have assessed guideline-concordant antibiotic use for patients hospitalized with CAP after the 2007 IDSA/ATS guidelines. We examine antibiotics prescribed and associated factors in adults hospitalized with CAP...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28729803/anterosuperior-rehabilitation-with-metal-free-fixed-prosthesis-based-on-zirconia
#15
Sthelen Nayara Cenci, Igor Alessandro Gontarsky, Marcella Goetz Moro, Lidia Olga Bach Pinheiro, Adriana Postiglione Bührer Samra
The loss of upper front dental elements causes functional and psychosocial problems to the affected individuals. In this case report, the treatment planning considered hard and soft tissue loss for a complex fixed partial denture (FPD) rehabilitation. The six-element, all-ceramic FPD was manufactured using a computer-aided design/computer-aided manufacturing system with zirconia framework, veneered with leucite-reinforced ceramic. Ceramic artificial gum was also produced to guarantee tooth-facial proportions as well as lip support, promoting both esthetics and phonetics...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28729692/extensive-astrocyte-synchronization-advances-neuronal-coupling-in-slow-wave-activity-in-vivo
#16
Zsolt Szabó, László Héja, Gergely Szalay, Orsolya Kékesi, András Füredi, Kornélia Szebényi, Árpád Dobolyi, Tamás I Orbán, Orsolya Kolacsek, Tamás Tompa, Zsombor Miskolczy, László Biczók, Balázs Rózsa, Balázs Sarkadi, Julianna Kardos
Slow wave activity (SWA) is a characteristic brain oscillation in sleep and quiet wakefulness. Although the cell types contributing to SWA genesis are not yet identified, the principal role of neurons in the emergence of this essential cognitive mechanism has not been questioned. To address the possibility of astrocytic involvement in SWA, we used a transgenic rat line expressing a calcium sensitive fluorescent protein in both astrocytes and interneurons and simultaneously imaged astrocytic and neuronal activity in vivo...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729672/plasmodium-berghei-p47-is-essential-for-ookinete-protection-from-the-anopheles-gambiae-complement-like-response
#17
Chiamaka Valerie Ukegbu, Maria Giorgalli, Hassan Yassine, Jose Luis Ramirez, Chrysanthi Taxiarchi, Carolina Barillas-Mury, George K Christophides, Dina Vlachou
Malaria is a mosquito-borne disease affecting millions of people every year. The rodent parasite Plasmodium berghei has served as a model for human malaria transmission studies and played a pivotal role in dissecting the mosquito immune response against infection. The 6-cysteine protein P47, known to be important for P. berghei female gamete fertility, is shown to serve a different function in Plasmodium falciparum, protecting ookinetes from the mosquito immune response. Here, we investigate the function of P...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729439/striatal-gpr88-modulates-foraging-efficiency
#18
Aundrea Rainwater, Elisenda Sanz, Richard D Palmiter, Albert Quintana
The striatum is anatomically and behaviorally implicated in behaviors that promote efficient foraging. To investigate this function, we studied instrumental choice behavior in mice lacking GPR88, a striatum-enriched orphan G-protein-coupled receptor that modulates striatal medium spiny neuron (MSN) excitability. Our results reveal that hungry mice lacking GPR88 (KO mice) were slow to acquire food-reinforced lever-press, but could lever press similar to controls on a progressive-ratio schedule. Both WT and KO mice discriminated between reward and no-reward levers; however, KO mice failed to discriminate based on relative quantity- reward (1 versus 3 food pellets) or effort (3 versus 9 lever presses)...
July 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28729236/adolescents-perspectives-on-personalized-e-feedback-in-the-context-of-health-risk-behavior-screening-for-primary-care-qualitative-study
#19
Garret G Zieve, Laura P Richardson, Katherine Katzman, Heather Spielvogle, Sandy Whitehouse, Carolyn A McCarty
BACKGROUND: Electronic health screening tools for primary care present an opportunity to go beyond data collection to provide education and feedback to adolescents in order to motivate behavior change. However, there is limited research to guide feedback message development. OBJECTIVE: The aim of this study was to explore youth perceptions of and preferences for receiving personalized feedback for multiple health risk behaviors and reinforcement for health promoting behaviors from an electronic health screening tool for primary care settings, using qualitative methodology...
July 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28728645/elevated-behavioral-economic-demand-for-alcohol-in-a-community-sample-of-heavy-drinking-smokers
#20
Michael Amlung, James MacKillop, Peter M Monti, Robert Miranda
OBJECTIVE: Cigarette smokers are more likely to consume alcohol at higher levels and experience poorer response to treatment for alcohol problems than are nonsmokers. One previous study in university students suggests that a potential reason for the high overlap between alcohol and tobacco use is that concurrent smoking is associated with overvaluation of alcohol, as reflected in elevated behavioral economic demand. The present study sought to extend these initial findings in a community sample with heavier levels of alcohol and tobacco use...
May 2017: Journal of Studies on Alcohol and Drugs
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