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https://www.readbyqxmd.com/read/28926305/structural-relationships-among-the-revised-reinforcement-sensitivity-theory-and-grandiose-and-vulnerable-narcissism
#1
Christopher C Spencer, Joshua D Foster, Jeffrey S Bedwell
Research shows that grandiosity and vulnerability are distinct aspects of narcissism. The Contemporary Clinical Model (CCM) of narcissism suggests that individuals fluctuate between grandiose narcissism (GN) and vulnerable narcissism (VN). The authors examine the relative contributions of the Behavioral Approach System (BAS), the Behavioral Inhibition System (BIS), and the Fight-Flight-Freeze System (FFFS) in the Revised Reinforcement Sensitivity Theory of Personality (r-RST) to GN and VN. Few studies examine the r-RST, and even fewer examine the VN and GN distinction...
September 19, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28925963/on-the-role-of-processing-parameters-in-producing-recycled-aluminum-aa6061-based-metal-matrix-composite-mmc-alr-prepared-using-hot-press-forging-hpf-process
#2
Azlan Ahmad, Mohd Amri Lajis, Nur Kamilah Yusuf
Solid-state recycling, which involves the direct recycling of scrap metal into bulk material using severe plastic deformation, has emerged as a potential alternative to the conventional remelting and recycling techniques. Hot press forging has been identified as a sustainable direct recycling technique that has fewer steps and maintains excellent material performance. An experimental investigation was conducted to explore the hardness and density of a recycled aluminum-based metal matrix composite by varying operating temperature and holding time...
September 19, 2017: Materials
https://www.readbyqxmd.com/read/28925962/strengthening-of-existing-bridge-structures-for-shear-and-bending-with-carbon-textile-reinforced-mortar
#3
Martin Herbrand, Viviane Adam, Martin Classen, Dominik Kueres, Josef Hegger
Increasing traffic loads and changes in code provisions lead to deficits in shear and flexural capacity of many existing highway bridges. Therefore, a large number of structures are expected to require refurbishment and strengthening in the future. This projection is based on the current condition of many older road bridges. Different strengthening methods for bridges exist to extend their service life, all having specific advantages and disadvantages. By applying a thin layer of carbon textile-reinforced mortar (CTRM) to bridge deck slabs and the webs of pre-stressed concrete bridges, the fatigue and ultimate strength of these members can be increased significantly...
September 19, 2017: Materials
https://www.readbyqxmd.com/read/28925358/preconditioned-cues-have-no-value
#4
Melissa Sharpe, Hannah Batchelor, Geoffrey Schoenbaum
Sensory preconditioning has been used to implicate midbrain dopamine in model-based learning, contradicting the view that dopamine transients reflect model-free value. However, it has been suggested that model-free value might accrue directly to the preconditioned cue through mediated learning. Here, building on previous work (Sadacca et al., 2016), we address this question by testing whether a preconditioned cue will support conditioned reinforcement in rats. We found that while both directly conditioned and second-order conditioned cues supported robust conditioned reinforcement, a preconditioned cue did not...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28924520/complete-remission-in-locally-advanced-breast-cancer-what-comprehensive-multi-modality-treatment-has-to-offer-in-sub-saharan-africa
#5
Gaurav Bhattacharya, Susan C Msadabwe-Chikuni, Roanne Segal, Omkar Inamdar, Catherine K Mwaba
Locally advanced breast cancer presents as a heterogeneous disease, but it is often best treated with aggressive combined modality therapy.  Commonly, it carries a more guarded prognosis. Given the above, it can be a particularly challenging entity to treat in resource-limited settings. We identify one such case with a relative lack of hormone receptor positivity in the sub-Saharan country of Zambia. Management of the disease was hampered by the challenges of resource constraints and communication gaps that are especially acute in low- to middle-income nations as compared to Western societies...
July 6, 2017: Curēus
https://www.readbyqxmd.com/read/28924317/comparative-evaluation-of-anchorage-reinforcement-between-orthodontic-implants-and-conventional-anchorage-in-orthodontic-management-of-bimaxillary-dentoalveolar-protrusion
#6
S S Chopra, Manish Mukherjee, Rajat Mitra, Gagan Deep Kochar, Abhijeet Kadu
BACKGROUND: Increased upper lip procumbency is commonly associated with maxillary dentoalveolar protrusion with the major goal of reducing maxillary dentoalveolar protrusion. The treatment plan usually includes extraction of the maxillary first premolars, followed by retraction of anterior teeth with maximum anchorage. Dental implants have been widely accepted as successful adjuncts for obtaining maximum anchorage in orthodontic treatment. METHODS: 50 subjects between the ages of 13 and 17 years having bimaxillary dentoalveolar protrusion were included in the study...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28924151/dna-methylomes-reveal-biological-networks-involved-in-human-eye-development-functions-and-associated-disorders
#7
María Berdasco, Antonio Gómez, Marcos J Rubio, Jaume Català-Mora, Vicente Zanón-Moreno, Miguel Lopez, Cristina Hernández, Shigeo Yoshida, Takahito Nakama, Keijiro Ishikawa, Tatsuro Ishibashi, Amina M Boubekeur, Lotfi Louhibi, Miguel A Pujana, Sergi Sayols, Fernando Setien, Dolores Corella, Carmen de Torres, Andreu Parareda, Jaume Mora, Ling Zhao, Kang Zhang, Matilde E Lleonart, Javier Alonso, Rafael Simó, Josep M Caminal, Manel Esteller
This work provides a comprehensive CpG methylation landscape of the different layers of the human eye that unveils the gene networks associated with their biological functions and how these are disrupted in common visual disorders. Herein, we firstly determined the role of CpG methylation in the regulation of ocular tissue-specification and described hypermethylation of retinal transcription factors (i.e., PAX6, RAX, SIX6) in a tissue-dependent manner. Second, we have characterized the DNA methylome of visual disorders linked to internal and external environmental factors...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923924/near-atomic-structure-of-jasplakinolide-stabilized-malaria-parasite-f-actin-reveals-the-structural-basis-of-filament-instability
#8
Sabrina Pospich, Esa-Pekka Kumpula, Julian von der Ecken, Juha Vahokoski, Inari Kursula, Stefan Raunser
During their life cycle, apicomplexan parasites, such as the malaria parasite Plasmodium falciparum, use actomyosin-driven gliding motility to move and invade host cells. For this process, actin filament length and stability are temporally and spatially controlled. In contrast to canonical actin, P. falciparum actin 1 (PfAct1) does not readily polymerize into long, stable filaments. The structural basis of filament instability, which plays a pivotal role in host cell invasion, and thus infectivity, is poorly understood, largely because high-resolution structures of PfAct1 filaments were missing...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923857/metalnc9-facilitates-lung-cancer-metastasis-via-a-pgk1-activated-akt-mtor-pathway
#9
Ming Yao, Tao Yu, Ying-Jun Zhao, Zhixiang Hu, Jing Li, Dandan Chu, Jiwei Zhang, Zhe Li, Bing Chen, Xiao Zhang, Hongyu Pan, Shengli Li, Hechun Lin, Lei Liu, Mingxia Yan, Xianghuo He
Long non-coding RNAs participate in carcinogenesis and tumor progression in lung cancer. Here we report the identification of a lncRNA signature associated with metastasis of non-small cell lung cancer (NSCLC). In particular, elevated expression of LINC00963 (MetaLnc9) in human NSCLC specimens correlated with poor prognosis, promoted migration and invasion of NSCLC cells in vitro, and enhanced lung metastasis formation in vivo. Mechanistic investigations showed that MetaLnc9 interacted with the glycolytic kinase PGK1 and prevented its ubiquitination in NSCLC cells, leading to activation of the oncogenic AKT/mTOR signaling pathway...
September 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28923772/reference-intervals-of-citrated-native-whole-blood-thromboelastography-in-premature-neonates
#10
Mario Motta, Brunetta Guaragni, Elena Pezzotti, Carmen Rodriguez-Perez, Gaetano Chirico
BACKGROUND: Bleeding due to acquired coagulation disorders is a common complication in premature neonates. In this clinical setting, standard coagulation laboratory tests might be unsuitable to investigate the hemostatic function as they reflect the concentration of pro-coagulant proteins but not of anti-coagulant proteins. Thromboelastography (TEG), providing a more complete assessment of hemostasis, may be able to overcome some of these limitations. Unfortunately, experience on the use of TEG in premature neonates is very limited and, in particular in this population, reference ranges of TEG parameters have not been yet evaluated...
September 15, 2017: Early Human Development
https://www.readbyqxmd.com/read/28923547/how-oral-environment-simulation-affects-ceramic-failure-behavior
#11
Ediléia Lodi, Kátia R Weber, Paula Benetti, Pedro H Corazza, Álvaro Della Bona, Márcia Borba
STATEMENT OF PROBLEM: Investigating the mechanical behavior of ceramics in a clinically simulated scenario contributes to the development of new and tougher materials, improving the clinical performance of restorations. The optimal in vitro environment for testing is unclear. PURPOSE: The purpose of this in vitro study was to investigate the failure behavior of a leucite-reinforced glass-ceramic under compression loading and fatigue in different simulated oral environment conditions...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28923451/-code-of-ethics-for-nurses-and-territory-hospital-group
#12
Jane-Laure Danan, François Giraud-Rochon
The publication of the decree relating to the code of ethics for nurses means that the State is producing a text for all nursing professionals, whatever their sector or their mode of practice. However, faced with the standardisation of nursing procedures, the production of a new standard by a government is not a neutral issue. On the one hand, it could constitute a reinforcement of the professional credibility of this corporation; on the other this text becomes enforceable on all nurses and employers. Within a territory hospital group, this reflection must form part of nursing and managerial practices and the relationships with the hospital administration...
September 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28923450/-the-impact-of-the-code-of-ethics-on-training
#13
Catherine Tirand-Martin
The publication of the French code of ethics for nurses, in November 2016, has had an impact on the training of student nurses. In this context, appropriation of the code is clearly facilitated by the form and definition of the text which immediately reinforces students' commitment on the path to professionalization.
September 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28923448/-the-code-of-ethics-for-nurses-history-and-perspectives
#14
Yann de Kerguenec
The French decree of 25 November 2016 relating to the code of ethics for nurses reinforces the principles guiding their missions and the corresponding responsibilities. It is the fruit of a collaboration between nurses from all backgrounds heavily involved in the Order. Imbued with the nursing spirit, reflecting the sensitivities and concerns of professionals, it is a unique project and, in every regard, quite remarkable, as it has been produced by a profession which is often reluctant to put pen to paper to express its vision of health...
September 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28923360/when-theory-and-biology-differ-the-relationship-between-reward-prediction-errors-and-expectancy
#15
Chad C Williams, Cameron D Hassall, Robert Trska, Clay B Holroyd, Olave E Krigolson
Comparisons between expectations and outcomes are critical for learning. Termed prediction errors, the violations of expectancy that occur when outcomes differ from expectations are used to modify value and shape behaviour. In the present study, we examined how a wide range of expectancy violations impacted neural signals associated with feedback processing. Participants performed a time estimation task in which they had to guess the duration of one second while their electroencephalogram was recorded. In a key manipulation, we varied task difficulty across the experiment to create a range of different feedback expectancies - reward feedback was either very expected, expected, 50/50, unexpected, or very unexpected...
September 15, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28923347/sulforaphane-improves-disrupted-er-mitochondria-interactions-and-suppresses-exaggerated-hepatic-glucose-production
#16
Emily Tubbs, Annika S Axelsson, Guillaume Vial, Claes B Wollheim, Jennifer Reuisset, Anders H Rosengren
AIMS: Exaggerated hepatic glucose production is one of the hallmarks of type 2 diabetes. Sulforaphane (SFN) has been suggested as a new potential anti-diabetic compound. However, the effects of SFN in hepatocytes are yet unclear. Accumulating evidence points to the close structural contacts between the ER and mitochondria, known as mitochondria-associated ER membranes (MAMs), as important hubs for hepatic metabolism. We wanted to investigate whether SFN could affect hepatic glucose production and MAMs...
September 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28922943/differential-prevalence-of-antibodies-against-adeno-associated-virus-in-healthy-children-and-patients-with-mucopolysaccharidosis-iii-perspective-for-aav-mediated-gene-therapy
#17
Haiyan Fu, Aaron S Meadows, Ricardo J Pineda, Krista L Kunkler, Kristen V Truxal, Kim L McBride, Kevin Flanigan, Douglas M McCarty
Recombinant AAV vectors are promising gene therapy tools. However, pre-existing antibodies (Abs) to many useful AAV serotypes pose a critical challenge for the translation of gene therapies. As part of AAV gene therapy program for treating MPS III patients, we investigated the seroprevalence profiles of AAV1-9 and rh74 in MPS IIIA/IIIB patients and in healthy children. Using ELISA for αAAV-IgG, we observed significantly higher sero-prevalence for AAV1 and AAVrh74 in 2-7y-old MPS III patients than in healthy controls...
September 19, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28922928/differential-reinforcement-of-low-rate-schedules-reduce-severe-problem-behavior
#18
Andrew C Bonner, John C Borrero
Differential-reinforcement-of-low-rate (DRL) schedules are reinforcement contingencies designed to reduce response rates. A common variation of the DRL arrangement is known as full-session DRL ( f-DRL), in which a reinforcer is presented at the end of an interval if the response rate during that interval is below a predetermined criterion. Prior human operant research involving arbitrary mouse clicks has shown that the f-DRL is likely to reduce target responding to near zero rates. Similarly, applied research has shown that the f-DRL is likely to reduce minimally disruptive classroom behavior...
September 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28922395/an-analysis-of-equine-round-pen-training-videos-posted-online-differences-between-amateur-and-professional-trainers
#19
Erin Kydd, Barbara Padalino, Cathrynne Henshall, Paul McGreevy
Natural Horsemanship is popular among many amateur and professional trainers and as such, has been the subject of recent scientific enquiry. One method commonly adopted by Natural Horsemanship (NH) trainers is that of round pen training (RPT). RPT sessions are usually split into a series of bouts; each including two phases: chasing/flight and chasing offset/flight offset. However, NH training styles are heterogeneous. This study investigated online videos of RPT to explore the characteristics of RPT sessions and test for differences in techniques and outcomes between amateurs and professionals (the latter being defined as those with accompanying online materials that promote clinics, merchandise or a service to the public)...
2017: PloS One
https://www.readbyqxmd.com/read/28922262/sugar-in-infants-children-and-adolescents-a-position-paper-of-the-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-committee-on-nutrition
#20
Nataša Fidler Mis, Christian Braegger, Jiri Bronsky, Cristina Campoy, Magnus Domellöf, Nicholas D Embleton, Iva Hojsak, Jessie Hulst, Flavia Indrio, Alexandre Lapillonne, Walter Mihatsch, Christian Molgaard, Rakesh Vora, Mary Fewtrell
The consumption of sugars, particularly sugar-sweetened beverages (SSBs; beverages or drinks that contain added caloric sweeteners (i.e. sucrose, high-fructose corn syrup, fruit-juice concentrates), in European children and adolescents exceeds current recommendations. This is of concern because there is no nutritional requirement for free sugars, and infants have an innate preference for sweet taste, which may be modified and reinforced by pre- and postnatal exposures. Sugar containing beverages/free sugars increase the risk for overweight/obesity and dental caries, can result in poor nutrient supply and reduced dietary diversity and may be associated with increased risk of type 2 diabetes mellitus, cardiovascular risk, and other health effects...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
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