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https://www.readbyqxmd.com/read/29149658/evaluating-casama-contextualized-semantic-maps-for-summarization-of-lung-cancer-studies
#1
Jean I Garcia-Gathright, Nicholas J Matiasz, Carlos Adame, Karthik V Sarma, Lauren Sauer, Nova F Smedley, Marshall L Spiegel, Jennifer Strunck, Edward B Garon, Ricky K Taira, Denise R Aberle, Alex A T Bui
OBJECTIVE: It is crucial for clinicians to stay up to date on current literature in order to apply recent evidence to clinical decision making. Automatic summarization systems can help clinicians quickly view an aggregated summary of literature on a topic. Casama, a representation and summarization system based on "contextualized semantic maps," captures the findings of biomedical studies as well as the contexts associated with patient population and study design. This paper presents a user-oriented evaluation of Casama in comparison to a context-free representation, SemRep...
November 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29149614/risky-business-the-circuits-that-impact-stress-induced-decision-making
#2
Amy F T Arnsten, Daeyeol Lee, Christopher Pittenger
How does stress promote risky decision-making? Friedman et al. find that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animals insensitive to potential losses. This may help explain how stress contributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette syndrome.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29149433/predictive-values-of-pulse-pressure-variation-and-stroke-volume-variation-for-fluid-responsiveness-in-patients-with-pneumoperitoneum
#3
Marko Zlicar, Vesna Novak-Jankovic, Rok Blagus, Maurizio Cecconi
Animal studies suggest that dynamic predictors remain useful in patients with pneumoperitoneum, but human data is conflicting. Our aim was to determine predictive values of pulse pressure variation (PPV) and stroke volume variation (SVV) in patients with pneumoperitoneum using LiDCORapid™ haemodynamic monitor. Standardised fluid challenges of colloid were administered to patients undergoing laparoscopic procedures, one fluid challenge per patient. Intra-abdominal pressure was automatically held at 12 mmHg...
November 17, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29149210/development-and-validation-of-open-source-software-for-dna-mixture-interpretation-based-on-a-quantitative-continuous-model
#4
Sho Manabe, Chie Morimoto, Yuya Hamano, Shuntaro Fujimoto, Keiji Tamaki
In criminal investigations, forensic scientists need to evaluate DNA mixtures. The estimation of the number of contributors and evaluation of the contribution of a person of interest (POI) from these samples are challenging. In this study, we developed a new open-source software "Kongoh" for interpreting DNA mixture based on a quantitative continuous model. The model uses quantitative information of peak heights in the DNA profile and considers the effect of artifacts and allelic drop-out. By using this software, the likelihoods of 1-4 persons' contributions are calculated, and the most optimal number of contributors is automatically determined; this differs from other open-source software...
2017: PloS One
https://www.readbyqxmd.com/read/29149206/automatic-structural-scene-digitalization
#5
Rui Tang, Yuhan Wang, Darren Cosker, Wenbin Li
In this paper, we present an automatic system for the analysis and labeling of structural scenes, floor plan drawings in Computer-aided Design (CAD) format. The proposed system applies a fusion strategy to detect and recognize various components of CAD floor plans, such as walls, doors, windows and other ambiguous assets. Technically, a general rule-based filter parsing method is fist adopted to extract effective information from the original floor plan. Then, an image-processing based recovery method is employed to correct information extracted in the first step...
2017: PloS One
https://www.readbyqxmd.com/read/29149195/age-of-heart-disease-presentation-and-dysmorphic-nuclei-in-patients-with-lmna-mutations
#6
Jason Q Core, Mehrsa Mehrabi, Zachery R Robinson, Alexander R Ochs, Linda A McCarthy, Michael V Zaragoza, Anna Grosberg
Nuclear shape defects are a distinguishing characteristic in laminopathies, cancers, and other pathologies. Correlating these defects to the symptoms, mechanisms, and progression of disease requires unbiased, quantitative, and high-throughput means of quantifying nuclear morphology. To accomplish this, we developed a method of automatically segmenting fluorescently stained nuclei in 2D microscopy images and then classifying them as normal or dysmorphic based on three geometric features of the nucleus using a package of Matlab codes...
2017: PloS One
https://www.readbyqxmd.com/read/29148836/automatic-sex-liking-and-sex-failure-associations-in-men-with-sexual-dysfunction
#7
Jacques J D M van Lankveld, Peter J de Jong, Marcus J M J Henckens, Philip den Hollander, Anja J H C van den Hout, Peter de Vries
Current models of sexual functioning imply an important role for both automatic and controlled appraisals. Accordingly, it can be hypothesized that erectile dysfunction may be due to the automatic activation of negative appraisals at the prospect of sexual intercourse. However, previous research showed that men with sexual dysfunction exhibited relatively strong automatic sex-positive instead of sex-negative associations. This study tested the robustness of this unexpected finding and, additionally, examined the hypothesis that perhaps more specific sex-failure versus sex-success associations are relevant in explaining sexual dysfunction and distress...
November 17, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29147963/inappropriate-anticholinergic-drugs-prescriptions-in-older-patients-analysing-a-hospital-database
#8
Laurie Ferret, Gregoire Ficheur, Emeline Delaviez, Michel Luyckx, Sophie Quenton, Regis Beuscart, Emmanuel Chazard, Jean-Baptiste Beuscart
Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009-2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia...
November 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29147954/a-fully-automatic-end-to-end-method-for-content-based-image-retrieval-of-ct-scans-with-similar-liver-lesion-annotations
#9
A B Spanier, N Caplan, J Sosna, B Acar, L Joskowicz
PURPOSE: The goal of medical content-based image retrieval (M-CBIR) is to assist radiologists in the decision-making process by retrieving medical cases similar to a given image. One of the key interests of radiologists is lesions and their annotations, since the patient treatment depends on the lesion diagnosis. Therefore, a key feature of M-CBIR systems is the retrieval of scans with the most similar lesion annotations. To be of value, M-CBIR systems should be fully automatic to handle large case databases...
November 16, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29147835/automatic-localization-of-the-left-ventricular-blood-pool-centroid-in-short-axis-cardiac-cine-mr-images
#10
Li Kuo Tan, Yih Miin Liew, Einly Lim, Yang Faridah Abdul Aziz, Kok Han Chee, Robert A McLaughlin
In this paper, we develop and validate an open source, fully automatic algorithm to localize the left ventricular (LV) blood pool centroid in short axis cardiac cine MR images, enabling follow-on automated LV segmentation algorithms. The algorithm comprises four steps: (i) quantify motion to determine an initial region of interest surrounding the heart, (ii) identify potential 2D objects of interest using an intensity-based segmentation, (iii) assess contraction/expansion, circularity, and proximity to lung tissue to score all objects of interest in terms of their likelihood of constituting part of the LV, and (iv) aggregate the objects into connected groups and construct the final LV blood pool volume and centroid...
November 17, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29147817/only-efficient-emotional-stimuli-affect-the-content-of-working-memory-during-free-recollection-from-natural-scenes
#11
Arianna Buttafuoco, Tiziana Pedale, Tony W Buchanan, Valerio Santangelo
Emotional events are thought to have privileged access to attention and memory, consuming resources needed to encode competing emotionally neutral stimuli. However, it is not clear whether this detrimental effect is automatic or depends on the successful maintenance of the specific emotional object within working memory. Here, participants viewed everyday scenes including an emotional object among other neutral objects followed by a free-recollection task. Results showed that emotional objects-irrespective of their perceptual saliency-were recollected more often than neutral objects...
November 17, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/29147660/analytical-validation-of-a-new-enzymatic-and-automatable-method-for-d-xylose-measurement-in-human-urine-samples
#12
Israel Sánchez-Moreno, Carmen Monsalve-Hernando, Ana Godino, Luis Illa, María Jesús Gaspar, Guillermo Manuel Muñoz, Ana Díaz, José Luis Martín, Eduardo García-Junceda, Alfonso Fernández-Mayoralas, Carmen Hermida
Hypolactasia, or intestinal lactase deficiency, affects more than half of the world population. Currently, xylose quantification in urine after gaxilose oral administration for the noninvasive diagnosis of hypolactasia is performed with the hand-operated nonautomatable phloroglucinol reaction. This work demonstrates that a new enzymatic xylose quantification method, based on the activity of xylose dehydrogenase from Caulobacter crescentus, represents an excellent alternative to the manual phloroglucinol reaction...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29147635/global-and-targeted-pathway-impact-of-gliomas-on-white-matter-integrity-based-on-lobar-localization
#13
David R Ormond, Shawn D'Souza, John A Thompson
Primary brain tumors comprise 28% of all tumors and 80% of malignant tumors. Pathophysiology of high-grade gliomas includes significant distortion of white matter architecture, necrosis, the breakdown of the blood brain barrier, and increased intracranial pressure. Diffusion tensor imaging (DTI), a diffusion weighted imaging technique, can be used to assess white matter architecture. Use of DTI as a non-invasive pathophysiological tool to analyze glioma impact on white matter microstructure has yet to be fully explored...
September 7, 2017: Curēus
https://www.readbyqxmd.com/read/29147579/autoimage-multiple-heat-maps-for-projected-coordinates
#14
Joshua P French
Heat maps are commonly used to display the spatial distribution of a response observed on a two-dimensional grid. The autoimage package provides convenient functions for constructing multiple heat maps in unified, seamless way, particularly when working with projected coordinates. The autoimage package natively supports: 1. automatic inclusion of a color scale with the plotted image, 2. construction of heat maps for responses observed on regular or irregular grids, as well as non-gridded data, 3. construction of a matrix of heat maps with a common color scale, 4...
2017: R Journal
https://www.readbyqxmd.com/read/29147563/a-novel-microaneurysms-detection-approach-based-on-convolutional-neural-networks-with-reinforcement-sample-learning-algorithm
#15
Umit Budak, Abdulkadir Şengür, Yanhui Guo, Yaman Akbulut
Microaneurysms (MAs) are known as early signs of diabetic-retinopathy which are called red lesions in color fundus images. Detection of MAs in fundus images needs highly skilled physicians or eye angiography. Eye angiography is an invasive and expensive procedure. Therefore, an automatic detection system to identify the MAs locations in fundus images is in demand. In this paper, we proposed a system to detect the MAs in colored fundus images. The proposed method composed of three stages. In the first stage, a series of pre-processing steps are used to make the input images more convenient for MAs detection...
December 2017: Health Information Science and Systems
https://www.readbyqxmd.com/read/29147548/automaticity-in-stimulus-parity-synaesthesia
#16
Tsvetomira Dumbalska, Rebekah C White, Mihaela D Duta, Kate Nation
Automaticity is a defining characteristic of synaesthesia. Here, we assess for automaticity in stimulus-parity synaesthesia; a subtype that has been documented only 3 times in the literature. Synaesthete R experiences many (nonnumerical) stimuli as being odd or even. She described a toy shape-sorter, which paired odd shapes with even colour slots (and vice versa) and relayed difficulties with the incongruency created by this simple toy. Inspired by this anecdote, we devised a computerised task in which Synaesthete R (and 10 control participants) indicated the location of a target shape, which was presented on a coloured bar...
November 2017: I-Perception
https://www.readbyqxmd.com/read/29146561/recurrent-neural-networks-with-specialized-word-embeddings-for-health-domain-named-entity-recognition
#17
Iñigo Jauregi Unanue, Ehsan Zare Borzeshi, Massimo Piccardi
BACKGROUND: Previous state-of-the-art systems on Drug Name Recognition (DNR) and Clinical Concept Extraction (CCE) have focused on a combination of text "feature engineering" and conventional machine learning algorithms such as conditional random fields and support vector machines. However, developing good features is inherently heavily time-consuming. Conversely, more modern machine learning approaches such as recurrent neural networks (RNNs) have proved capable of automatically learning effective features from either random assignments or automated word "embeddings"...
November 13, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29146319/developing-a-machine-vision-system-for-simultaneous-prediction-of-freshness-indicators-based-on-tilapia-oreochromis-niloticus-pupil-and-gill-color-during-storage-at-4%C3%A2-c
#18
Ce Shi, Jianping Qian, Shuai Han, Beilei Fan, Xinting Yang, Xiaoming Wu
The study assessed the feasibility of developing a machine vision system based on pupil and gill color changes in tilapia for simultaneous prediction of total volatile basic nitrogen (TVB-N), thiobarbituric acid (TBA) and total viable counts (TVC) during storage at 4°C. The pupils and gills were chosen and color space conversion among RGB, HSI and L(∗)a(∗)b(∗) color spaces was performed automatically by an image processing algorithm. Multiple regression models were established by correlating pupil and gill color parameters with TVB-N, TVC and TBA (R(2)=0...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29146191/automatic-delineation-of-brain-regions-on-mri-and-pet-images-from-the-pig
#19
Jonas Villadsen, Hanne D Hansen, Louise M Jørgensen, Sune H Keller, Flemming L Andersen, Ida N Petersen, Gitte M Knudsen, Claus Svarer
BACKGROUND: The increasing use of the pig as a research model in neuroimaging requires standardized processing tools. For example, extraction of regional dynamic time series from brain PET images requires parcellation procedures that benefit from being automated. COMPARISON WITH EXISTING METHODS: Manual inter-modality spatial normalization to a MRI atlas is operator-dependent, time-consuming, and can be inaccurate with lack of cortical radiotracer binding or skull uptake...
November 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29145750/feasibility-of-on-line-temperature-based-hyperthermia-treatment-planning-to-improve-tumour-temperatures-during-locoregional-hyperthermia
#20
H P Kok, L Korshuize-van Straten, A Bakker, R de Kroon-Oldenhof, G H Westerveld, E Versteijne, L J A Stalpers, J Crezee
BACKGROUND: The effectiveness of hyperthermia is strongly dependent on the achieved tumour temperatures. Phased-array systems allow flexible power steering to realise good tumour heating while avoiding excessive heating in normal tissue, but the limited quantitative accuracy of pre-treatment planning complicates realising optimal tumour heating. On-line hyperthermia treatment planning could help to improve the heating quality. This paper demonstrates the feasibility of using on-line temperature-based treatment planning to improve the heating quality during hyperthermia in three patients...
November 16, 2017: International Journal of Hyperthermia
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