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https://www.readbyqxmd.com/read/28545280/-impacts-of-early-metoprolol-intervention-on-connexin-43-and-phosphorylated-connexin-43-expression-in-rabbits-with-experimental-myocardial-infarction
#1
M Zhou, Q Lu, J Q Jiang, Z N Chen, Z G Gong, Z G Li, W W Fu, S F Ding
Objective: To investigate the early intervention effects of metoprolol on connexin 43(Cx43) and phosphorylated Cx43 (p-Cx43) expression in rabbits with post myocardial infarction. Methods: A total of 24 adult male New Zealand white rabbits were divided into sham group (n=6), early treatment group(n=6), routine treatment group(n=6), and myocardial infarction group(n=6) with a randomized block design blocked by weight. Myocardial infarction was induced by left anterior descending coronary artery (LAD) ligation...
April 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28545105/research-on-calibrating-rock-mechanical-parameters-with-a-statistical-method
#2
Zhen Liu, Ye Guo, Shuheng Du, Gengyu Wu, Mao Pan
Research on the modeling of rock mechanics parameters is of great significance to the exploration of oil and gas. The use of logging data with the Kriging interpolation to study rock mechanics parameters has been proven to be effective in reservoir prediction and other oilfield applications and can provide additional data. However, there will sometimes be a great deviation due to the limited samples and the strong heterogeneity of a layer. To solve this problem, a new approach was proposed to calibrate rock mechanical models through the statistical analysis of logging data...
2017: PloS One
https://www.readbyqxmd.com/read/28545068/automatically-tracking-neurons-in-a-moving-and-deforming-brain
#3
Jeffrey P Nguyen, Ashley N Linder, George S Plummer, Joshua W Shaevitz, Andrew M Leifer
Advances in optical neuroimaging techniques now allow neural activity to be recorded with cellular resolution in awake and behaving animals. Brain motion in these recordings pose a unique challenge. The location of individual neurons must be tracked in 3D over time to accurately extract single neuron activity traces. Recordings from small invertebrates like C. elegans are especially challenging because they undergo very large brain motion and deformation during animal movement. Here we present an automated computer vision pipeline to reliably track populations of neurons with single neuron resolution in the brain of a freely moving C...
May 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28544928/achieving-advanced-nitrogen-removal-for-small-flow-wastewater-using-a-baffled-bioreactor-bbr-with-intermittent-aeration
#4
Guoqiang Liu, Jianmin Wang
Nitrogen discharge from decentralized and onsite wastewater treatment systems, such as recirculating sand filters, stabilization ponds, and septic tanks, is an important source of groundwater and surface water contamination. This study demonstrated a simple baffled bioreactor (BBR) technology, operated with an intermittent aeration mode, that effectively removed nearly all nitrogen for small flow wastewater treatment. The BBR is characterized by an aeration zone, followed by an integrated internal settler, which automatically retains a high biomass concentration of approximately 6 g/L without using a separate sludge return device...
May 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28544685/dermal-abrasion-due-to-semi-automatic-intraosseous-device
#5
Hirokazu Takei, Osamu Nomura, Motoki Yasuda, Nobuaki Inoue
No abstract text is available yet for this article.
May 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28544583/improving-the-occupational-skills-of-students-with-intellectual-disability-by-applying-video-prompting-combined-with-dance-pads
#6
Mei-Lan Lin, Ming-Shan Chiang, Ching-Hsiang Shih, Meng-Fang Li
BACKGROUND: Individuals with intellectual disability (ID) are prone to inattention, are slow in learning and reaction, and have deficits in memory skills. Providing proper vocational education and training for individuals with intellectual disability is able to enhance their occupational skills. MATERIALS AND METHODS: This study applied video prompting to provide instructional prompts to help participants accurately perform an assigned occupational activity. A control system installed with developed software was used to turn a standard dance pad into a sensor to detect the participants' standing position and to automatically trigger video prompting...
May 24, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28544476/usefulness-of-a-decision-tree-model-for-the-analysis-of-adverse-drug-reactions-evaluation-of-a-risk-prediction-model-of-vancomycin-associated-nephrotoxicity-constructed-using-a-data-mining-procedure
#7
Shungo Imai, Takehiro Yamada, Kumiko Kasashi, Masaki Kobayashi, Ken Iseki
OBJECTIVES: Several publications concerning decision tree (DT) analysis in medical fields have recently demonstrated its usefulness for defining prognostic factors in various diseases. However, there are minimal reports on the predictors of adverse drug reactions. We attempted to use DT analysis to discover combinations of multiple risk factors that would increase the risk of nephrotoxicity associated with vancomycin (VCM). To demonstrate the usefulness of DT analysis, we compared its predictive performance with that of multiple logistic regression analysis...
May 23, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28543788/automated-verification-of-pulmonary-vein-isolation-in-radiofrequency-and-cryoballoon-guided-ablation
#8
Jan De Pooter, Thomas Phlips, Milad El Haddad, Frederic van Heuverswyn, Liesbeth Timmers, René Tavernier, Sebastien Knecht, Yves Vandekerckhove, Mattias Duytschaever
BACKGROUND: Verification of pulmonary vein isolation (PVI) can be challenging due to the coexistence of pulmonary vein potentials (PVP) and far field potentials. This study aimed to prospectively validate a novel algorithm for automated verification of PVI in radiofrequency-guided (RF) and cryoballoon-guided (CB) ablation strategies. METHODS: A dataset of 620 (RF: 516 EGMs and CB: 104 EGMs) bipolar electrograms (EGM), recorded by circular mapping catheter (CMC) placed at the left atrium-pulmonary vein (PV) junction, were prospectively analyzed by a two-step algorithm...
May 25, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28543787/accurate-determination-of-brain-metabolite-concentrations-using-eretic-as-external-reference
#9
Niklaus Zoelch, Andreas Hock, Susanne Heinzer-Schweizer, Nikolai Avdievitch, Anke Henning
Magnetic Resonance Spectroscopy (MRS) can provide in vivo metabolite concentrations in standard concentration units if a reliable reference signal is available. For (1) H MRS in the human brain, typically the signal from the tissue water is used as the (internal) reference signal. However, a concentration determination based on the tissue water signal most often requires a reliable estimate of the water concentration present in the investigated tissue. Especially in clinically interesting cases, this estimation might be difficult...
May 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28543725/tutorial-for-the-structure-elucidation-of-small-molecules-by-means-of-the-lsd-software
#10
Jean-Marc Nuzillard, Bertrand Plainchont
Automatic structure elucidation of small molecules by means of the "Logic for Structure Elucidation" software (LSD) is introduced in the context of the automatic exploitation of chemical shift correlation data and with minimal input from chemical shift values. The first step in solving a structural problem by means of LSD is the extraction of pertinent data from the 1D and 2D spectra. This operation requires the labeling of the resonances and of their correlations; its reliability highly depends on the quality of the spectra...
May 24, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28543091/intraoperative-localized-constrained-registration-in-navigated-bronchoscopy
#11
Erlend Fagertun Hofstad, Hanne Sorger, Janne Beate Lervik Bakeng, Lucian Gruionu, Håkon Olav Leira, Tore Amundsen, Thomas Langø
PURPOSE: One of the major challenges in electromagnetic navigated bronchoscopy is the navigation accuracy. An initial rigid image-to-patient registration may not be optimal for the entire lung volume, as the lung tissue anatomy is likely to have shifted since the time of computer tomography (CT) acquisition. The accuracy of the initial rigid registration will also be affected throughout the procedure by breathing, coughing, patient movement and tissue displacements due to pressure from bronchoscopy tools...
May 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28542248/the-detection-of-faked-identity-using-unexpected-questions-and-mouse-dynamics
#12
Merylin Monaro, Luciano Gamberini, Giuseppe Sartori
The detection of faked identities is a major problem in security. Current memory-detection techniques cannot be used as they require prior knowledge of the respondent's true identity. Here, we report a novel technique for detecting faked identities based on the use of unexpected questions that may be used to check the respondent identity without any prior autobiographical information. While truth-tellers respond automatically to unexpected questions, liars have to "build" and verify their responses. This lack of automaticity is reflected in the mouse movements used to record the responses as well as in the number of errors...
2017: PloS One
https://www.readbyqxmd.com/read/28542234/robust-auto-weighted-multi-view-subspace-clustering-with-common-subspace-representation-matrix
#13
Wenzhang Zhuge, Chenping Hou, Yuanyuan Jiao, Jia Yue, Hong Tao, Dongyun Yi
In many computer vision and machine learning applications, the data sets distribute on certain low-dimensional subspaces. Subspace clustering is a powerful technology to find the underlying subspaces and cluster data points correctly. However, traditional subspace clustering methods can only be applied on data from one source, and how to extend these methods and enable the extensions to combine information from various data sources has become a hot area of research. Previous multi-view subspace methods aim to learn multiple subspace representation matrices simultaneously and these learning task for different views are treated equally...
2017: PloS One
https://www.readbyqxmd.com/read/28541914/an-ultralow-power-sleep-spindle-detection-system-on-chip
#14
Saam Iranmanesh, Esther Rodriguez-Villegas
This paper describes a full system-on-chip to automatically detect sleep spindle events from scalp EEG signals. These events, which are known to play an important role on memory consolidation during sleep, are also characteristic of a number of neurological diseases. The operation of the system is based on a previously reported algorithm, which used the Teager energy operator, together with the Spectral Edge Frequency (SEF50) achieving more than 70% sensitivity and 98% specificity. The algorithm is now converted into a hardware analog based customized implementation in order to achieve extremely low levels of power...
May 24, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28541892/automatic-detection-of-retinal-lesions-for-screening-of-diabetic-retinopathy
#15
Sudeshna Sil Kar, Santi Maity
OBJECTIVE: Diabetic Retinopathy (DR) is characterized by the progressive deterioration of retina with the appearance of different types of lesions that include microaneurysms, hemorrhages, exudates etc. Detection of these lesions plays significant role for early diagnosis of DR. METHODS: To this aim, this paper proposes a novel and automated lesion detection scheme which consists of the four main steps: vessel extraction and optic disc removal, pre-processing, candidate lesion detection and post-processing...
May 24, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28541574/accuracy-of-size-specific-dose-estimate-calculation-from-center-slice-in-computed-tomography
#16
Johannes Boos, Patric Kröpil, Oliver Th Bethge, Joel Aissa, Christoph Schleich, Lino Morris Sawicki, Niklas Heinzler, Gerald Antoch, Christoph Thomas
To evaluate the accuracy of size-specific dose estimate (SSDE) calculation from center slice with water-equivalent diameter (Dw) and effective diameter (Deff). A total of 1812 CT exams (1583 adult and 229 pediatric) were included in this retrospective study. Dw and Deff were automatically calculated for all slices of each scan. SSDEs were calculated with two methods: (1) from the center slice; and (2) from all slices of the volume, which was regarded as the reference standard. Impact of patient weight, height and body mass index (BMI) on SSDE accuracy was assessed...
May 25, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28541493/identifying-reports-of-randomized-controlled-trials-rcts-via-a-hybrid-machine-learning-and-crowdsourcing-approach
#17
Byron C Wallace, Anna Noel-Storr, Iain J Marshall, Aaron M Cohen, Neil R Smalheiser, James Thomas
Objectives: Identifying all published reports of randomized controlled trials (RCTs) is an important aim, but it requires extensive manual effort to separate RCTs from non-RCTs, even using current machine learning (ML) approaches. We aimed to make this process more efficient via a hybrid approach using both crowdsourcing and ML. Methods: We trained a classifier to discriminate between citations that describe RCTs and those that do not. We then adopted a simple strategy of automatically excluding citations deemed very unlikely to be RCTs by the classifier and deferring to crowdworkers otherwise...
May 25, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28541278/sharing-data-under-the-21st-century-cures-act
#18
REVIEW
Mary A Majumder, Christi J Guerrini, Juli M Bollinger, Robert Cook-Deegan, Amy L McGuire
On 13 December 2016, President Obama signed the 21st Century Cures Act ("the Act") into law. Many of its provisions support the creation of an "Information Commons," an ecosystem of separate but interconnected initiatives that facilitate open and responsible sharing of genomic and other data for research and clinical purposes. For example, the Act supports the National Institutes of Health in mandating data sharing, provides funding and guidance for the large national cohort program now known as All of Us, expresses congressional support for a global pediatric study network, and strengthens patient access to health information...
May 25, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28541221/subspace-weighting-co-clustering-of-gene-expression-data
#19
Xiaojun Chen, Joshua Zhexue Huang, Qingyao Wu, Min Yang
Microarray technology enables the collection of vast amounts of gene expression data from biological experiments. Clustering algorithms have been successfully applied to exploring the gene expression data. Since a set of genes may be possible correlated to a subset of samples, it is useful to use co-clustering to recover co-clusters in the gene expression data. In this paper, we propose a novel algorithm, called Subspace Weighting Co-Clustering (SWCC), for high dimensional gene expression data. In SWCC, a gene subspace weight matrix is introduced to identify the contribution of gene objects in distinguishing different sample clusters...
May 18, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28541213/error-free-text-typing-performance-of-an-inductive-intra-oral-tongue-computer-interface-for-severely-disabled-individuals
#20
Lotte Andreasen Struijk, Bo Bentsen, Michael Gaihede, Eugen Lontis
For severely paralyzed individuals, alternative computer interfaces are becoming increasingly essential for everyday life as social and vocational activities are facilitated by information technology and as the environment becomes more automatic and remotely controllable. Tongue computer interfaces have proven to be desirable by the users partly due to their high degree of aesthetic acceptability, but so far the mature systems have shown a relatively low error-free text typing efficiency. This study evaluated the intra-oral inductive tongue computer interface (ITCI) in its intended use: Error-free text typing in a generally available text editing system, Word©...
May 19, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
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