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https://www.readbyqxmd.com/read/28732232/periodicity-and-stability-for-variable-time-impulsive-neural-networks
#1
Hongfei Li, Chuandong Li, Tingwen Huang
The paper considers a general neural networks model with variable-time impulses. It is shown that each solution of the system intersects with every discontinuous surface exactly once via several new well-proposed assumptions. Moreover, based on the comparison principle, this paper shows that neural networks with variable-time impulse can be reduced to the corresponding neural network with fixed-time impulses under well-selected conditions. Meanwhile, the fixed-time impulsive systems can be regarded as the comparison system of the variable-time impulsive neural networks...
June 29, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28727541/ic04750post-discharge-smoking-cessation-in-subgroups-of-hospitalized-smokers-a-latent-class-analysis
#2
Thomas Ylioja, Gerald Cochran, Yuchiao Chang, Hilary A Tindle, Nancy A Rigotti
CLEAN VERSION ABSTRACT Background: Hospitalization presents a window of opportunity to treat smoking, and hospital-initiated smoking treatment has demonstrated effectiveness. Despite effective interventions, not all smokers will discontinue use, highlighting the need to better understand which patients achieve cessation. Traditional regression methods may not capture the complexity of inpatient smoker subgroups. METHODS: We conducted latent class analysis (LCA) with data from 397 hospitalized adult cigarette smokers enrolled in a randomized trial...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28712882/perfusion-of-muscle-flaps-independent-of-the-anatomical-vascular-pedicle-pedicle-autonomy
#3
K Bradshaw, M Wagels
INTRODUCTION: Free muscle flaps are being used more commonly for complex lower limb reconstruction. Up to 33% of flaps used to reconstruct lower limb trauma will require an orthopaedic procedure after reconstruction. To date there have been only case reports detailing the variable survival of muscle flaps after actual or simulated pedicle injury and the process and timeframe of neovascularisation remains undefined. We aim to show that perfusion of a muscle flap is possible after injury to its anatomical vascular pedicle...
June 7, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28712617/cost-effectiveness-analysis-of-an-automated-medication-system-implemented-in-a-danish-hospital-setting
#4
Bettina Wulff Risør, Marianne Lisby, Jan Sørensen
OBJECTIVES: To evaluate the cost-effectiveness of an automated medication system (AMS) implemented in a Danish hospital setting. METHODS: An economic evaluation was performed alongside a controlled before-and-after effectiveness study with one control ward and one intervention ward. The primary outcome measure was the number of errors in the medication administration process observed prospectively before and after implementation. To determine the difference in proportion of errors after implementation of the AMS, logistic regression was applied with the presence of error(s) as the dependent variable...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28700805/efficacy-of-lisdexamfetamine-in-adults-with-moderate-to-severe-binge-eating-disorder-a-randomized-clinical-trial
#5
James I Hudson, Susan L McElroy, M Celeste Ferreira-Cornwell, Jana Radewonuk, Maria Gasior
Importance: The ability of pharmacotherapies to prevent relapse and maintain efficacy with long-term treatment in psychiatric conditions is important. Objective: To assess lisdexamfetamine dimesylate maintenance of efficacy in adults with moderate to severe binge-eating disorder. Design, Setting, and Participants: A multinational, phase 3, double-blind, placebo-controlled, randomized withdrawal study including 418 participants was conducted at 49 clinical research study sites from January 27, 2014, to April 8, 2015...
July 12, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28697385/quantitative-contamination-assessment-of-escherichia-coli-in-baby-spinach-primary-production-in-spain-effects-of-weather-conditions-and-agricultural-practices
#6
Ana Allende, Irene Castro-Ibáñez, Roland Lindqvist, María Isabel Gil, Mieke Uyttendaele, Liesbeth Jacxsens
A quantitative microbial contamination model of Escherichia coli during primary production of baby spinach was developed. The model included only systematic contamination routes (e.g. soil and irrigation water) and it was used to evaluate the potential impact of weather conditions, agricultural practices as well as bacterial fitness in soil on the E. coli levels present in the crop at harvest. The model can be used to estimate E. coli contamination of baby spinach via irrigation water, via soil splashing due to irrigation water or rain events, and also including the inactivation of E...
June 27, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28692121/molecular-analysis-of-the-gstt1-gene-polymorphism-in-patients-with-clinical-manifestation-of-atherosclerosis
#7
J V M Martins, D A Rodrigues, K S F Silva, I R Costa, M H Lagares, F L Campedelli, A M Barbosa, M P Morais, K K V O Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regulate endothelial function, coagulation, inflammation, metabolism of amino acids, lipids, and carbohydrates. Glutathione S-transferases (GST) are enzymes that catalyze the polymorphic detoxification of metabolites produced by oxidative stress within the cells, which is induced by reactive oxygen species...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28689327/in-utero-evidence-of-impaired-somatic-growth-in-hypoplastic-left-heart-syndrome
#8
Jourdan E Triebwasser, Marjorie C Treadwell
We hypothesized that fetuses with hypoplastic left heart syndrome (HLHS) have impaired growth compared to expected growth for gestational age. This is a retrospective cohort study including singleton fetuses with isolated HLHS identified from a single, referral center's ultrasound database. To account for variable timing of ultrasounds, z-scores for gestational age were assigned for each biometric parameter. We identified 169 fetuses, of which 96 had more than one ultrasound. The median number of ultrasound evaluations per fetus was 2 (range 1-5)...
July 8, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28676834/exponentially-modified-peak-functions-in-biomedical-sciences-and-related-disciplines
#9
A Golubev
In many cases relevant to biomedicine, a variable time, which features a certain distribution, is required for objects of interest to pass from an initial to an intermediate state, out of which they exit at random to a final state. In such cases, the distribution of variable times between exiting the initial and entering the final state must conform to the convolution of the first distribution and a negative exponential distribution. A common example is the exponentially modified Gaussian (EMG), which is widely used in chromatography for peak analysis and is long known as ex-Gaussian in psychophysiology, where it is applied to times from stimulus to response...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28638496/effect-of-early-follow-up-after-hospital-discharge-on-outcomes-in-patients-with-heart-failure-or-chronic-obstructive-pulmonary-disease-a-systematic-review
#10
(no author information available yet)
BACKGROUND: Transitions in care can increase patients' vulnerability to adverse events. In particular, patients admitted for heart failure or chronic obstructive pulmonary disorder (COPD) have high rates of readmission and return emergency department visits. Heart failure patients have the highest 30-day readmission rates in Canada, and COPD patients comprise the highest volume of readmissions. Combined, these two conditions account for the largest number of emergency department returns...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28623680/what-are-the-incidence-and-factors-associated-with-implant-fracture
#11
Reza Tabrizi, Hossein Behnia, Shahram Taherian, Nima Hesami
PURPOSE: Implant fracture is a serious complication, which leads to treatment failure. The purpose of this study is to estimate the incidence of implant fractures and identify factors associated with them. MATERIALS AND METHODS: In this retrospective cohort study, the sample was derived from 2 implant centers. The predictors were grouped into the following categories: demographic, location of implant, physical characteristic of implant, implant-abutment connection, type of prosthesis, type of retention, and outcome variable (time to implant fracture)...
May 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28616728/the-relationship-of-cancer-characteristics-and-patient-outcome-with-time-to-lung-cancer-diagnosis-after-an-abnormal-screening-ct
#12
Sushilkumar K Sonavane, Paul Pinsky, Jubal Watts, David S Gierada, Reginald Munden, Satinder P Singh, Hrudaya Nath
PURPOSE: The National Lung Screening Trial (NLST) demonstrated a reduction in lung cancer and all-cause mortality with low-dose CT (LDCT) screening. The aim of our study was to examine the time to diagnosis (TTD) of lung cancer in the LDCT arm of the NLST and assess its relationship with cancer characteristics and survival. METHODS: The subjects (N = 462) with a positive baseline screen and subsequent lung cancer diagnosis within 3 years were evaluated by data and image review to confirm the baseline abnormality...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28606624/-impact-of-education-program-and-clinical-posting-in-psychiatry-on-medical-students-stigmatizing-attitudes-towards-psychiatry-and-psychiatric-disorders
#13
N Simon, H Verdoux
OBJECTIVE: The aim of the study was to explore whether a medical student education program and clinical posting in psychiatry had an impact on medical students' stigmatizing attitudes towards psychiatry and psychiatric disorders. METHODS: Medical students from the University of Bordeaux were recruited during their 4-year course at the beginning of the academic education program in psychiatry. Medical students who were concomitantly in a clinical posting in wards of psychiatry or neurology were invited to participate in the study...
June 9, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28585873/a-simple-composite-metric-for-the-assessment-of-glycemic-status-from-continuous-glucose-monitoring-data-implications-for-clinical-practice-and-the-artificial-pancreas
#14
Irl B Hirsch, Andrew K Balo, Kevin Sayer, Arturo Garcia, Bruce A Buckingham, Thomas A Peyser
BACKGROUND: The potential clinical benefits of continuous glucose monitoring (CGM) have been recognized for many years, but CGM is used by a small fraction of patients with diabetes. One obstacle to greater use of the technology is the lack of simplified tools for assessing glycemic control from CGM data without complicated visual displays of data. METHODS: We developed a simple new metric, the personal glycemic state (PGS), to assess glycemic control solely from continuous glucose monitoring data...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28582395/mechanisms-of-generation-of-membrane-potential-resonance-in-a-neuron-with-multiple-resonant-ionic-currents
#15
David M Fox, Hua-An Tseng, Tomasz G Smolinski, Horacio G Rotstein, Farzan Nadim
Neuronal membrane potential resonance (MPR) is associated with subthreshold and network oscillations. A number of voltage-gated ionic currents can contribute to the generation or amplification of MPR, but how the interaction of these currents with linear currents contributes to MPR is not well understood. We explored this in the pacemaker PD neurons of the crab pyloric network. The PD neuron MPR is sensitive to blockers of H- (IH) and calcium-currents (ICa). We used the impedance profile of the biological PD neuron, measured in voltage clamp, to constrain parameter values of a conductance-based model using a genetic algorithm and obtained many optimal parameter combinations...
June 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28578041/microbiota-source-impact-in-vitro-metabolite-colonic-production-and-anti-proliferative-effect-of-spent-coffee-grounds-on-human-colon-cancer-cells-ht-29
#16
Angélica María Hernández-Arriaga, B Dave Oomah, Rocio Campos-Vega
Human gut flora-mediated non-digestible fraction of spent coffee grounds (hgf-NDSCG) was evaluated for its chemopreventive effect and molecular mechanisms involved on human colon adenocarcinoma HT-29 cell survival using two different microbiota source [lean (L) and overweight (OW)]. The source of human gut flora (hgf) (L or OW) affected the pH of hgf-NDSCG only minimally, but linearly reduced those of hgf-inulin. The variability between lean and overweight microbiota was characterized by the metabolism and/or bioaccessibility of different phenolic metabolites, their intermediate and end products as well as by variable time courses...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28572782/timing-of-gun-fire-influences-sprinters-multiple-joint-reaction-times-of-whole-body-in-block-start
#17
Mitsuo Otsuka, Toshiyuki Kurihara, Tadao Isaka
Experienced sprinters are specifically adapted to pre-planning an advanced motor program. Herein, sprinters are able to immediately accelerate their center of mass forward with a whole-body coordinated motion, following a steady state crouched position. We examined the effect of variable timing of reaction signals on multiple joint reaction times (RT) and whole-body RT for specialist sprinters. Twenty well-experienced male sprinters performed five start-dashes from a block start under five variable foreperiod (FP) length conditions (1...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28570587/non-standard-radiotherapy-fractionations-delay-the-time-to-malignant-transformation-of-low-grade-gliomas
#18
Araceli Henares-Molina, Sebastien Benzekry, Pedro C Lara, Marcial García-Rojo, Víctor M Pérez-García, Alicia Martínez-González
Grade II gliomas are slowly growing primary brain tumors that affect mostly young patients. Cytotoxic therapies (radiotherapy and/or chemotherapy) are used initially only for patients having a bad prognosis. These therapies are planned following the "maximum dose in minimum time" principle, i. e. the same schedule used for high-grade brain tumors in spite of their very different behavior. These tumors transform after a variable time into high-grade gliomas, which significantly decreases the patient's life expectancy...
2017: PloS One
https://www.readbyqxmd.com/read/28546040/early-carotid-endarterectomy-provides-a-better-neurological-outcome-in-symptomatic-patients-a-single-center-experience
#19
Gianfranco Varetto, Lorenzo Gibello, Francesca Sperti, Alessandra Trevisan, Edoardo Frola, Paolo Garneri, Pietro Rispoli
BACKGROUND: Many studies confirmed the role of early carotid endarterectomy (CEA) to prevent recurrent stroke or transient ischemic attack; however, the mid-long-term neurological benefit is still not completely investigated. The purpose of the study was to evaluate the role of early CEA on the perioperative and postoperative stroke/death complications of patients with a symptomatic carotid stenosis. METHODS: Ninety consecutive patients were referred to our center for a symptomatic carotid stenosis...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28542444/regional-brain-amyloid-%C3%AE-accumulation-associates-with-domain-specific-cognitive-performance-in-parkinson-disease-without-dementia
#20
Rizwan S Akhtar, Sharon X Xie, Yin J Chen, Jacqueline Rick, Rachel G Gross, Ilya M Nasrallah, Vivianna M Van Deerlin, John Q Trojanowski, Alice S Chen-Plotkin, Howard I Hurtig, Andrew D Siderowf, Jacob G Dubroff, Daniel Weintraub
Parkinson disease patients develop clinically significant cognitive impairment at variable times over their disease course, which is often preceded by milder deficits in memory, visuo-spatial, and executive domains. The significance of amyloid-β accumulation to these problems is unclear. We hypothesized that amyloid-β PET imaging by 18F-florbetapir, a radiotracer that detects fibrillar amyloid-β plaque deposits, would identify subjects with global cognitive impairment or poor performance in individual cognitive domains in non-demented Parkinson disease patients...
2017: PloS One
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