Read by QxMD icon Read


Mercedes G Vázquez, Pablo N Affranchino, Andrea Schon, Eduardo Otero, Pablo Young, Patricia Breyter
Goldbloom syndrome is a rare clinical entity, of unknown etiology that happens almost exclusively in pediatric population. It is a prolonged febrile syndrome with periosteal hyperostosis and dysproteinemia, and often simulates an hematooncology or lymphoproliferative disease. The diagnosis is to rule out the different causes of bone pain associated with hypergammaglobulinemia, hypoalbuminemia, high erythrocyte sedimentation rate and periostitis at the radiographies. Symptomatology, radiology and laboratory parameters refer in a variable time, usually from 3 to 12 months...
April 1, 2018: Archivos Argentinos de Pediatría
Jingyuan Xie, Jicheng Lv, Weiming Wang, Guisen Li, Zhangsuo Liu, Hongyu Chen, Feifei Xu, Jing Sun, Yan Ouyang, Xiaoyan Zhang, Meng Yang, Manman Shi, Wen Zhang, Hong Ren, Krzysztof Kiryluk, Hong Zhang, Nan Chen
BACKGROUND: The clinical course of immunoglobulin A (IgA) nephropathy (IgAN) is highly variable, making it difficult to predict which patients are at risk for rapid progression. The aim of this study was to develop and validate a kidney failure risk prediction equation for adults with IgAN. STUDY DESIGN: Multicenter retrospective cohort study of 2,155 Chinese patients with IgAN. CANDIDATE PREDICTORS: Clinical and histology variables. OUTCOMES: Time to end-stage renal disease (ESRD)...
March 16, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Arjang Talattof, Gordon L Amidon
Fasted-state gastrointestinal (GI) fluid transit is typically represented as a first-order, deterministic process (averaged and viewed as a continuous approximation). It is, however, most likely a discrete process involving fluid packets interrupted by variable time periods of little to no fluid emptying. In this report we present a physiologically based pulsed-packet gastric fluid emptying model and evaluate it with respect to recent gastrointestinal fluid volume emptying results, published gastric emptying of various dosage forms, and gastric fluid emptying as a function of GI motility...
March 5, 2018: Molecular Pharmaceutics
Isabel Cuesta-López, Marina Sánchez-Cuervo, Ángel Candela-Toha, Juana Benedí-González, Teresa Bermejo-Vicedo
OBJECTIVE: To evaluate the efficiency of the protocolization and centralization of  the preparation of intravenous vasoactive drug mixtures in the treatment of  critically ill patients. METHOD: A prospective interventional study (July 2012-December 2014) was  conducted to measure the impact of different vasoactive drug protocols on costs  in the treatment of critically ill patients. The economic impact was measured by  comparing the direct costs (fixed and variable) of the preparation of intravenous  vasoactive drug mixtures in the Pharmacy Department with their traditional  preparation in hospital care units...
March 1, 2018: Farmacia Hospitalaria
Ilse Haveman, Hanneke Fleurke-Rozema, Eduard J H Mulder, Manon Benders, Gideon du Marchie Sarvaas, Henriette Ter Heide, Roel H de Heus, Caterina M Bilardo
OBJECTIVES: There is evidence that in fetuses with congenital heart defects (CHD) head growth is affected. However, scanty data is available on longitudinal growth patterns of other biometric parameters such as abdominal circumference (AC) and femur length (FL). Aim was to evaluate growth patterns in fetuses with isolated CHD diagnosed prenatally in different categories of lesions. METHODS: Fetuses with isolated CHD seen between 2008 and 2013 at the Fetal Medicine Unit of two tertiary referral centers were retrospectively included in the study...
March 1, 2018: Prenatal Diagnosis
Denada Dibra, Xueqing Xia, Mihai Gagea, Guillermina Lozano, Shulin Li
Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model with which to study the biology of this disease and to develop therapeutics is lacking. One of the most accepted animal models for this disease uses HLA-B27/Hu-β2m transgenic rats; however, only 30%-50% of male HLA-B27/Hu-β2m rats develop spontaneous, clinically apparent spondylitis and have a variable time until disease onset. Here, we report a high-incidence, low-variation spontaneous mouse model that delineates how the combination of inflammatory cytokine interleukin-27 (IL-27) signaling deficiency and mitogenic signaling (mutant p53R172H) in vivo, leads to bone loss in the vertebral bodies and ossification of the cartilage in the intervertebral discs...
2018: PloS One
Satya Surbhi, Ilana Graetz, Jim Y Wan, Justin Gatwood, James E Bailey
BACKGROUND: Nonadherence to essential chronic medications has been identified as a potential driver of high health care costs in superutilizers of inpatient services. Few studies, however, have documented the levels of nonadherence and factors associated with nonadherence in this high-cost, vulnerable population. OBJECTIVE: To examine the factors associated with nonadherence to essential chronic medications, with special emphasis on mental illness and use of opioid medications...
March 2018: Journal of Managed Care & Specialty Pharmacy
Steven M Boker, Mike Martin
The 10 year anniversary of the COGITO Study provides an opportunity to revisit the ideas behind the Cattell data box. Three dimensions of the persons × variables × time data box are discussed in the context of three categories of researchers each wanting to answer their own categorically different question. The example of the well-known speed-accuracy tradeoff is used to illustrate why these are three different categories of statistical question. The 200 persons by 100 variables by 100 occasions of measurement COGITO data cube presents a challenge to integrate theories and methods across the dimensions of the data box...
February 26, 2018: Multivariate Behavioral Research
Kimberly D Tran, Nicolas A Yannuzzi, Nancy Si, Nimesh A Patel, Darlene Miller, Guillermo Amescua, Audina M Berrocal, Harry W Flynn
Purpose: To report the clinical features organisms and treatment outcomes in patients with endophthalmitis after penetrating keratoplasty (PK). Methods: Retrospective noncomparative case series. Results: Eleven eyes of 11 patients with culture positive endophthalmitis after PK were included. The time to diagnosis of endophthalmitis from last PK was less than 1 week in 3/11 (27%), between 1 and 4 weeks in 3/11 (27%), and greater than one month in 5/11 (46%) (range 2-924 days)...
March 2018: American Journal of Ophthalmology Case Reports
Hannah Hoseyni, Yan Xu, Honghui Zhou
Therapeutic drug monitoring (TDM), or the measurement of drug concentrations in blood and antidrug antibodies, for biologic therapies used to treat inflammatory bowel disease (IBD) is an area of growing interest within the IBD community. When there is a definable relationship between drug concentration and clinical effect, blood concentration of biologics (and antidrug antibodies assessment) could be used to predict patient response and to titrate the biologics to maximize therapeutic benefit. This dose individualization has been proven to be more efficacious and cost-effective than empiric dose adjustment and can better guide therapeutic decisions regarding therapy withdrawal or switch...
February 20, 2018: Journal of Clinical Pharmacology
Amanda R Smolock, Mircea M Cristescu, Audrey Hinshaw, Kaitlin M Woo, Shane A Wells, Timothy J Ziemlewicz, Meghan G Lubner, Prasad S Dalvie, J Louis Hinshaw, Christopher L Brace, Orhan S Ozkan, Fred T Lee, Paul Laeseke
PURPOSE: To compare transarterial chemoembolization (TACE) monotherapy to combination TACE and microwave ablation (MWA) for local control of 3- to 5-cm hepatocellular carcinoma (HCC). METHODS: Patients with HCC between 3 and 5 cm treated with TACE monotherapy or combination TACE + MWA at a single institution between 2007 and 2016 were retrospectively reviewed. Twenty-four HCCs (median diameter 3.8 cm) in 16 patients (13 males; median age 64 years) were treated using TACE monotherapy...
February 15, 2018: Abdominal Radiology
Benício Daniela Ferreira Araújo, Pereira Luciana Oliveira, Silva Izabel Cristina Rodrigues da, Azevedo Ricardo Bentes, Bezerra Ana Cristina Barreto
The aim of this study was to investigate the viability of human dental pulp cells from extracted teeth kept at standard room temperature and atmospheric pressure for different periods of time. Twenty-one healthy permanent teeth were used. They were divided into five groups according to the expected time from extraction to processing. One group was tested immediately after extraction; the other groups were each tested at one of the following time points: 30 minutes, 1 hour, 2 hours, and 5 hours post-extraction...
February 1, 2018: Brazilian Oral Research
Mateus Rossato, Rodolfo André Dellagrana, Raphael Luiz Sakugawa, Caetano Decian Lazzari, Bruno Manfredini Baroni, Fernando Diefenthaeler
The aim of this study was to identify the effects of two different time responses on fatigue of knee extensor. Sixteen male volunteers (26±6.0 years 81±12 kg, and 181±7.4 cm) participated of study. Participants performed the same protocol in five sessions, [control, placebo (placebo applied both 6 hours before and immediately before the test), 6h before + immediately before (PBMT applied both 6 hours before and immediately before the test), 6h before (PBMT applied 6 hours before and placebo applied immediately before the test), and immediately before (placebo applied 6 hours before and PBMT applied immediately before the test)]...
January 29, 2018: Journal of Strength and Conditioning Research
John Shen, Jason Chang, Melody Mendenhall, Grace Cherry, Jonathan W Goldman, Rajan P Kulkarni
Background: The anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies have shown exceptional activity in many cancers. However, these immunotherapies can also result in diverse adverse cutaneous eruptions that need to be better characterized for ongoing management. The objective was to provide clinical and histopathologic descriptions of the variety of cutaneous adverse events seen in patients who received anti-PD-1/PD-L1 treatment and discuss their management...
2018: Therapeutic Advances in Medical Oncology
E Cullen, M Fernández-Mazuecos, B J Glover
Background and Aims: Nectar spurs (tubular outgrowths of a floral organ which contain, or give the appearance of containing, nectar) are hypothesized to be a 'key innovation' which can lead to rapid speciation within a lineage, because they are involved in pollinator specificity. Despite the ecological importance of nectar spurs, relatively little is known about their development. We used a comparative approach to investigate variation in nectar spur length in a clade of eight Iberian toadflaxes...
January 23, 2018: Annals of Botany
Ross D Cranston, Jonathan R Baker, Aaron Siegel, Rhonda M Brand, Laura Janocko, Ian McGowan
BACKGROUND: Imiquimod can be used to treat internal anal high-grade squamous intraepithelial lesions. In HIV-1-infected individuals there is a theoretical concern for increased HIV replication in anorectal tissue secondary to imiquimod-induced mucosal inflammation. OBJECTIVE: The purpose of this study was to assess local virologic, immunologic, and pathologic effects of imiquimod treatment in HIV-infected individuals. DESIGN: This was a pilot study at a single academic center...
March 2018: Diseases of the Colon and Rectum
Audrey C Ford, Hannah Gramling, Samuel C Li, Jessica V Sov, Amrita Srinivasan, Lisa A Pruitt
Polycarbonate polyurethane has cartilage-like, hygroscopic, and elastomeric properties that make it an attractive material for orthopedic joint replacement application. However, little data exists on the cyclic loading and fracture behavior of polycarbonate polyurethane. This study investigates the mechanisms of fatigue crack growth in polycarbonate polyurethane with respect to time dependent effects and conditioning. We studied two commercially available polycarbonate polyurethanes, Bionate® 75D and 80A. Tension testing was performed on specimens at variable time points after being removed from hydration and variable strain rates...
January 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Elias P Casula, Isabella M S Mayer, Mahalekshmi Desikan, Sarah J Tabrizi, John C Rothwell, Michael Orth
BACKGROUND: In Huntington's disease there is evidence of structural damage in the motor system, but it is still unclear how to link this to the behavioral disorder of movement. One feature of choreic movement is variable timing and coordination between sequences of actions. We postulate this results from desynchronization of neural activity in cortical motor areas. OBJECTIVES: The objective of this study was to explore the ability to synchronize activity in a motor network using transcranial magnetic stimulation and to relate this to timing of motor performance...
January 22, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Fang Liang, Daniel J Browne, Megan J Gray, Kate H Gartlan, David D Smith, Ross T Barnard, Geoffrey R Hill, Simon R Corrie, Kate A Markey
Bloodstream infection is a significant clinical problem, particularly in vulnerable patient groups such as those undergoing chemotherapy and bone marrow transplantation. Clinical diagnostics for suspected bloodstream infection remain centered around blood culture (highly variable timing, in the order of hours to days to become positive), and empiric use of broad-spectrum antibiotics is therefore employed for patients presenting with febrile neutropenia. Gram-typing provides the first opportunity to target therapy (e...
January 31, 2018: ACS Infectious Diseases
Ana Beatriz D Grisolia, Christine C Nelson
Distichiasis is a challenging condition that may require multiple surgical interventions. Besides ophthalmologic concerns in children, distichiasis may be part of the lymphedema-distichiasis syndrome, which presents with lymphedema of variable time of onset. Other significant systemic disorders such as coarctation of the aorta and varicose veins have been reported in association with this syndrome and must be reviewed for proper patient care. The authors report the case of a 22-year-old male patient who had been treated for distichiasis and followed for 16 years...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"