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https://www.readbyqxmd.com/read/28195515/targeting-cell-adhesion-molecules-with-nanoparticles-using-in%C3%A2-vivo-and-flow-based-in%C3%A2-vitro-models-of-atherosclerosis
#1
Khosrow Khodabandehlou, Jacqueline J Masehi-Lano, Christopher Poon, Jonathan Wang, Eun Ji Chung
Atherosclerosis is a leading cause of death worldwide; in addition to lipid dysfunction, chronic arterial wall inflammation is a key component of atherosclerosis. Techniques that target cell adhesion molecules, which are overexpressed during inflammation, are effective methods to detect and treat atherosclerosis. Specifically, research groups have identified vascular cell adhesion molecule-1, intercellular adhesion molecule-1, platelet endothelial cell adhesion molecule, and selectins (E-selectin and P-selectin) as correlated to atherogenesis...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28192363/combined-risk-assessment-of-nonstationary-monthly-water-quality-based-on-markov-chain-and-time-varying-copula
#2
Wei Shi, Jun Xia
Water quality risk management is a global hot research linkage with the sustainable water resource development. Ammonium nitrogen (NH3-N) and permanganate index (CODMn) as the focus indicators in Huai River Basin, are selected to reveal their joint transition laws based on Markov theory. The time-varying moments model with either time or land cover index as explanatory variables is applied to build the time-varying marginal distributions of water quality time series. Time-varying copula model, which takes the non-stationarity in the marginal distribution and/or the time variation in dependence structure between water quality series into consideration, is constructed to describe a bivariate frequency analysis for NH3-N and CODMn series at the same monitoring gauge...
February 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28191484/photoinduced-molecular-chirality-probed-by-ultrafast-resonant-x-ray-spectroscopy
#3
Jérémy R Rouxel, Markus Kowalewski, Shaul Mukamel
Recently developed circularly polarized X-ray light sources can probe the ultrafast chiral electronic and nuclear dynamics through spatially localized resonant core transitions. We present simulations of time-resolved circular dichroism signals given by the difference of left and right circularly polarized X-ray probe transmission following an excitation by a circularly polarized optical pump with the variable time delay. Application is made to formamide which is achiral in the ground state and assumes two chiral geometries upon optical excitation to the first valence excited state...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28176821/spatial-variation-and-inconsistency-between-estimates-of-onset-of-muscle-activation-from-emg-and-ultrasound
#4
Angela V Dieterich, Alberto Botter, Taian Martins Vieira, Anneli Peolsson, Frank Petzke, Paul Davey, Deborah Falla
Delayed onset of muscle activation can be a descriptor of impaired motor control. Activation onset can be estimated from electromyography (EMG)-registered muscle excitation and from ultrasound-registered muscle motion, which enables non-invasive measurements in deep muscles. However, in voluntary activation, EMG- and ultrasound-detected activation onsets may not correspond. To evaluate this, ten healthy men performed isometric elbow flexion at 20% to 70% of their maximal force. Utilising a multi-channel electrode transparent to ultrasound, EMG and M(otion)-mode ultrasound were recorded simultaneously over the biceps brachii muscle...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28158296/characteristics-of-cyclist-crashes-in-italy-using-latent-class-analysis-and-association-rule-mining
#5
Gabriele Prati, Marco De Angelis, Víctor Marín Puchades, Federico Fraboni, Luca Pietrantoni
The factors associated with severity of the bicycle crashes may differ across different bicycle crash patterns. Therefore, it is important to identify distinct bicycle crash patterns with homogeneous attributes. The current study aimed at identifying subgroups of bicycle crashes in Italy and analyzing separately the different bicycle crash types. The present study focused on bicycle crashes that occurred in Italy during the period between 2011 and 2013. We analyzed categorical indicators corresponding to the characteristics of infrastructure (road type, road signage, and location type), road user (i...
2017: PloS One
https://www.readbyqxmd.com/read/28157669/waiting-2%C3%A2-minutes-after-sucrose-administration-unnecessary
#6
Naomi Meesters, Sinno Simons, Joost van Rosmalen, Irwin Reiss, John van den Anker, Monique van Dijk
BACKGROUND: Worldwide, oral sucrose is standard of care in many neonatal intensive care units to relieve procedural pain in neonates. This study aims to determine if time interval between sucrose administration and heelstick correlates with pain scores. METHODS: Neonates were prospectively studied with variable time intervals and assessed with the Premature Infant Pain Profile-Revised (PIPP-R). RESULTS: 150 neonates were included with a median gestational age of 30(+6) (IQR 27(+6)-33(+2)) weeks and a median time interval of 72 (IQR 39-115) seconds between sucrose administration and heelstick...
March 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28129954/-reactive-arthritis-due-to-clostridium-difficile-report-of-two-cases-and-literature-review
#7
P Garrigues, T de Roux, E Georgilopoulos, E Wanono, A Mathieu
INTRODUCTION: Reactive arthritis due to Clostridium difficile infection is uncommon. CASE REPORTS: We report two cases of reactive arthritis associated with C. difficile infection that occurred in a 40-year-old woman and a 47-year-old man. The literature review between 1976 (date of first reported case) and 2016 retrieved 54 observations (including our two cases). Reactive arthritis occurs most frequently in young subjects after a variable time frame according to C...
January 24, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28125504/therapeutic-drug-monitoring-of-everolimus-comparability-of-concentrations-determined-by-two-immunoassays-and-a-lc-ms-ms-method
#8
Maria Shipkova, Sonja Rapp, Raül Rigo-Bonnin, Eberhard Wieland, Andreas Peter
BACKGROUND: Therapeutic drug monitoring (TDM) is recommended to guide therapy with the immunosuppressant Everolimus (EVL) in solid organ transplantation to prevent rejections and to limit toxicity. For TDM, pre-dose EVL concentrations are measured in whole blood mainly by liquid chromatography tandem mass spectrometry (LC-MS/MS). In addition, two immunoassays (QMS® Everolimus and Elecsys® Everolimus) are commercially available. The aim of this study was to evaluate the comparability of EVL results determined with the two immunoassays and a validated LC-MS/MS test using samples from kidney (KT)-liver (LT)- and heart (HT) transplant recipients...
January 24, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28119257/diagnosis-and-outcomes-of-collateral-arterial-formation-after-irreversible-early-hepatic-artery-thrombosis-in-pediatric-liver-recipients
#9
Li-Hong Gu, Feng-Hua Li, Qiang Xia, Hua Fang, Shi-Jun Zhang, Long-Zhi Han
BACKGROUND: Early hepatic artery thrombosis (eHAT) has been recognized as an important cause of graft loss and mortality. However, the incidence, etiology and outcome are not clear, especially for children. The present study was to investigate the formation of collateral artery flow after irreversible eHAT and its impact on patient's prognosis. METHODS: We analyzed eHAT after liver transplantation in children from October 2006 to April 2015 in our center, illustrated the formation of collateral hepatic artery flow after irreversible eHAT and explored the diagnosis, complications, treatment and prognosis...
February 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28118045/impact-of-a-paper-based-dynamic-insulin-infusion-protocol-on-glycemic-variability-time-in-target-and-hypoglycemic-risk-a-stepped-wedge-trial-in-medical-intensive-care-unit-patients
#10
Antoine Clergeau, Jean-Jacques Parienti, Yves Reznik, Deborah Clergeau, Amelie Seguin, Xavier Valette, Damien du Cheyron, Michael Joubert
BACKGROUND: Stress-induced hyperglycemia is a common feature of intensive care unit (ICU) patients. Besides mean blood glucose (BG) level, glucose variability and hypoglycemia have been highlighted as independent predictors of ICU and hospital mortality. Recent ICU recommendations suggest using insulin infusion protocols that can minimize glucose variability and hypoglycemic risk. Our aim was to assess the efficacy, safety, and acceptance by nurses of a paper-based simple dynamic insulin protocol compared with those by nurses of a paper-based static protocol...
February 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28105655/imperfect-de-convolution-may-introduce-spurious-psychophysiological-interactions-and-how-to-avoid-it
#11
Xin Di, Richard C Reynolds, Bharat B Biswal
Psychophysiological interaction (PPI) is a widely used regression-based method to study connectivity changes in different experimental conditions. A PPI effect is generated by point-by-point multiplication of a psychological variable (experimental design) and a physiological variable (time series of a seed region). If the psychological variable is non-centered with a constant component, the constant component will add a physiological variable to the PPI term. The physiological component would in theory be accounted for by the physiological main effect in the model...
January 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28098494/constant-and-variable-time-delays-of-synchrony-of-facial-expressions-in-dyadic-conversations
#12
M Joseph Meyer
No abstract text is available yet for this article.
January 18, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28097673/schoolyard-shade-and-sun-exposure-assessment-of-personal-monitoring-during-children-s-physical-activity
#13
Jennifer K Vanos, Grant R McKercher, Kylie Naughton, Marc Lochbaum
Childhood exposure to ultraviolet radiation (UVR) is a major risk factor for the development of melanoma later in life. However, it is challenging to accurately determine personal outdoor exposure to UVR, specifically erythemally-weighted UVR (UVEry ), due to technological constraints, variable time-activity patterns, and the influence of outdoor environmental design. To address this challenge, the current study utilized mobile and stationary techniques to examine the UVEry exposures of 14 children in a schoolyard in Lubbock, TX in spring 2016...
January 18, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28096408/rhythm-judgments-reveal-a-frequency-asymmetry-in-the-perception-and-neural-coding-of-sound-synchrony
#14
Magdalena Wojtczak, Anahita H Mehta, Andrew J Oxenham
In modern Western music, melody is commonly conveyed by pitch changes in the highest-register voice, whereas meter or rhythm is often carried by instruments with lower pitches. An intriguing and recently suggested possibility is that the custom of assigning rhythmic functions to lower-pitch instruments may have emerged because of fundamental properties of the auditory system that result in superior time encoding for low pitches. Here we compare rhythm and synchrony perception between low- and high-frequency tones, using both behavioral and EEG techniques...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28093579/progression-of-transsynaptic-retinal-degeneration-with-spectral-domain-optical-coherence-tomography
#15
Stephen G Schwartz, Armando Monroig, Harry W Flynn
PURPOSE: To illustrate the progression of retrograde transsynaptic retinal degeneration using spectral- domain optical coherence tomography (SD-OCT). OBSERVATIONS: A 60 year-old man with a stroke was followed over a 17-month period using SD-OCT of the macula, ganglion cell layer (GCC), and retinal nerve fiber layer. Transsynaptic retinal degeneration progressed over this time. CONCLUSIONS AND IMPORTANCE: Retrograde transsynaptic retinal degeneration may occur in patients with homonymous visual field loss caused by post-geniculate neurologic disease...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/28081533/eeg-monitoring-technique-influences-the-management-of-hypoxic-ischemic-seizures-in-neonates-undergoing-therapeutic-hypothermia
#16
Saber Jan, Frances J Northington, Charlamaine M Parkinson, Carl E Stafstrom
Electroencephalogram (EEG) monitoring techniques for neonatal hypoxia-ischemia (HI) are evolving over time, and the specific type of EEG utilized could influence seizure diagnosis and management. We examined whether the type of EEG performed affected seizure treatment decisions (e.g., the choice and number of antiseizure drugs [ASDs]) in therapeutic hypothermia-treated neonates with HI from 2007 to 2015 in the Johns Hopkins Hospital Neonatal Intensive Care Unit. During this period, 3 different EEG monitoring protocols were utilized: Period 1 (2007-2009), single, brief conventional EEG (1 h duration) at a variable time during therapeutic hypothermia treatment, i...
January 17, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28065378/difference-in-diaphragmatic-motion-during-tidal-breathing-in-a-standing-position-between-copd-patients-and-normal-subjects-time-resolved-quantitative-evaluation-using-dynamic-chest-radiography-with-flat-panel-detector-system-dynamic-x-ray-phrenicography
#17
Yoshitake Yamada, Masako Ueyama, Takehiko Abe, Tetsuro Araki, Takayuki Abe, Mizuki Nishino, Masahiro Jinzaki, Hiroto Hatabu, Shoji Kudoh
OBJECTIVES: To quantitatively compare diaphragmatic motion during tidal breathing in a standing position between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography. MATERIALS AND METHODS: Thirty-nine COPD patients (35 males; age, 71.3±8.4years) and 47 normal subjects (non-smoker healthy volunteers) (20 males; age, 54.8±9.8years) underwent sequential chest radiographs during tidal breathing using dynamic chest radiography with a flat panel detector system...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28050214/satisfaction-of-elderly-hearing-aid-users
#18
Lorena Kozlowski, Angela Ribas, Gleide Almeida, Idalina Luz
Introduction The impact of auditory sensory deprivation in the life of an individual is enormous because it not only affects one's ability to properly understand auditory information, but also the way people relate to their environment and their culture. The monitoring of adult and elderly subjects with hearing loss is intended to minimize the difficulties and handicaps that occur as a consequence of this pathology. Objective To evaluate the level of user satisfaction with hearing aids. Methods A clinical and experimental study involving 91 elderly hearing aid users...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28046980/we-fg-206-05-new-arterial-spin-labeling-method-for-simultaneous-estimation-of-arterial-cerebral-blood-volume-cerebral-blood-flow-and-arterial-transit-time
#19
M Johnston, H Liu, C Whitlow, Y Jung
PURPOSE: To demonstrate the feasibility of a novel Arterial Spin Labeling (ASL) method for simultaneously measuring cerebral blood flow (CBF), arterial transit time (ATT), and arterial cerebral blood volume (aCBV) without the use of a contrast agent. METHODS: A series of multi-TI ASL images were acquired from one healthy subject on a 3T Siemens Skyra, with the following parameters: PCASL labeling with variable TI [300, 400, 500, 600, 700, 800, 900, 1000, 1500, 2000, 2500, 3000, 3500, 4000] ms, labeling bolus 1400 ms when TI allows, otherwise 100 ms less than TI, TR was minimized for each TI, two sinc shaped pre-saturation pulses were applied in the imaging plane immediately before 2D EPI acquisition...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28001270/speech-language-pathology-assessment-for-tracheal-decannulation-in-patients-suffering-from-traumatic-brain-injury
#20
Isabel de Lima Zanata, Rosane Sampaio Santos, Jair Mendes Marques, Gisela Carmona Hirata, Daiane Aparecida Dos Santos
Purpose: To describe the effect of Speech-Language Pathology (SLP) management on the tracheal decannulation process in patients with traumatic brain injury (TBI). Methods: Prospective controlled clinical study. Two groups of patients with TBI confirmed by computed axial tomography were included in the study group (G1) and control group (G2) composed of 30 individuals each, with 25 (83.3%) male and 5 (16.7%) female individuals in both groups. Patients' age ranged from 18 to 53 years old - mean age was 32 years...
November 2016: CoDAS
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