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https://www.readbyqxmd.com/read/29148865/metronomic-therapy-has-low-toxicity-and-is-as-effective-as-current-standard-treatment-for-recurrent-high-risk-neuroblastoma
#1
Frank Berthold, Marc Hömberg, Inna Proleskovskaya, Pavel Mazanek, Margarita Belogurova, Angela Ernst, Jaroslav Sterba
The metronomic therapy concept uses low doses of continuously applied chemotherapeutic, anti-angiogenetic, and immunomodulating drugs. Twenty patients with recurrent and 3 with refractory high-risk neuroblastoma were treated by the metronomic concept using celecoxib, cyclophosphamide, vinblastine, and etoposide for up to 24 months. The outcome was compared to 274 matched patients with a first recurrence from stage 4 neuroblastoma using the variables time from diagnosis to first recurrence, number of organs involved, and MYCN amplification...
November 17, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29117533/late-arriving-signals-contribute-less-to-cell-fate-decisions
#2
Michael G Cortes, Jimmy T Trinh, Lanying Zeng, Gábor Balázsi
Gene regulatory networks are largely responsible for cellular decision-making. These networks sense diverse external signals and respond by adjusting gene expression, enabling cells to reach environment-dependent decisions crucial for their survival or reproduction. However, information-carrying signals may arrive at variable times. Besides the intrinsic strength of these signals, their arrival time (timing) may also carry information about the environment and can influence cellular decision-making in ways that are poorly understood...
November 7, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29114725/association-between-adolescent-preventive-care-and-the-role-of-the-affordable-care-act
#3
Sally H Adams, M Jane Park, Lauren Twietmeyer, Claire D Brindis, Charles E Irwin
Importance: Despite decades of adolescent preventive well visit and services promotion (Guidelines for Adolescent Preventive Services and Bright Futures), rates are below recommended levels and little is known of the effect of the Patient Protection and Affordable Care Act (ACA) implementation on these care rates. Objectives: To use Medical Expenditure Panel Survey data to determine (1) whether adolescent well visit rates increased from the pre-ACA period to post-ACA period, and (2) whether caregivers' reports of past-year preventive services delivery increased from the pre- to post-ACA period among adolescents with any past-year health care visit...
November 6, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29106901/robust-h%C3%A2-cost-guaranteed-integral-sliding-mode-control-for-the-synchronization-problem-of-nonlinear-tele-operation-system-with-variable-time-delay
#4
Saba Al-Wais, Suiyang Khoo, Tae Hee Lee, Lakshmanan Shanmugam, Saeid Nahavandi
This paper is devoted to the synchronization problem of tele-operation systems with time-varying delay, disturbances, and uncertainty. Delay-dependent sufficient conditions for the existence of integral sliding surfaces are given in the form of Linear Matrix Inequalities (LMIs). This guarantees the global stability of the tele-operation system with known upper bounds of the time-varying delays. Unlike previous work, in this paper, the controller gains are designed but not chosen, which increases the degree of freedom of the design...
October 27, 2017: ISA Transactions
https://www.readbyqxmd.com/read/29106303/dynamics-of-core-body-temperature-cycles-in-long-term-measurements-under-real-life-conditions-in-women
#5
D Ekhart, H Wicht, T Kersken, H Ackermann, M Kaczmarczyk, G Pretzsch, H Alexander, H W Korf
Studies under real life conditions become more and more relevant in chronobiological and chronomedical research. The present study aims to analyze one of the most prominent biological rhythms: the core body temperature (CBT) rhythm in the real world outside the laboratory. CBT was recorded continuously in 37 healthy women (age between 21 and 44 years, median 29 years) with a newly developed intravaginal temperature sensor for up to 102 days. Sleep logs were available from 23 participants. To quantify the daily dynamics of each individual CBT-curve, novel measurement parameters are introduced which permit the quantification of the phase and shape of the CBT rhythms as well as their relation to the sleep-wake cycle...
November 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29102856/validity-and-reliability-of-an-iphone-app-to-assess-time-velocity-and-leg-power-during-a-sit-to-stand-functional-performance-test
#6
Juan Diego Ruiz-Cárdenas, Juan José Rodríguez-Juan, Rowan R Smart, Jennifer M Jakobi, Gareth R Jones
The purposes of this study were: (i) Analyze the concurrent validity and reliability of an iPhone App for measuring time, velocity and power during a single sit-to-stand (STS) test compared with measurements recorded from a force plate; and (ii) Evaluate the relationship between the iPhone App measures with age and functional performance. Forty-eight healthy individuals (age range: 26-81 years) were recruited. All participants completed a STS test on a force plate with the movement recorded on an iPhone 6 at 240 frames-per-second...
October 31, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29090398/photobiomodulation-therapy-for-the-improvement-of-muscular-performance-and-reduction-of-muscular-fatigue-associated-with-exercise-in-healthy-people-a-systematic-review-and-meta-analysis
#7
REVIEW
Adriane Aver Vanin, Evert Verhagen, Saulo Delfino Barboza, Leonardo Oliveira Pena Costa, Ernesto Cesar Pinto Leal-Junior
Researches have been performed to investigate the effects of phototherapy on improving performance and reduction of muscular fatigue. However, a great variability in the light parameters and protocols of the trials are a concern to establish the efficacy of this therapy to be used in sports or clinic. The aim of this study is to investigate the effectiveness, moment of application of phototherapy within an exercise protocol, and which are the parameters optimally effective for the improvement of muscular performance and the reduction of muscular fatigue in healthy people...
October 31, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29075457/territory-surveillance-and-prey-management-wolves-keep-track-of-space-and-time
#8
Ulrike E Schlägel, Evelyn H Merrill, Mark A Lewis
Identifying behavioral mechanisms that underlie observed movement patterns is difficult when animals employ sophisticated cognitive-based strategies. Such strategies may arise when timing of return visits is important, for instance to allow for resource renewal or territorial patrolling. We fitted spatially explicit random-walk models to GPS movement data of six wolves (Canis lupus; Linnaeus, 1758) from Alberta, Canada to investigate the importance of the following: (1) territorial surveillance likely related to renewal of scent marks along territorial edges, to reduce intraspecific risk among packs, and (2) delay in return to recently hunted areas, which may be related to anti-predator responses of prey under varying prey densities...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29059066/transition-to-cancer-survivorship-a-concept-analysis
#9
Sylvia K Wood
Transition to cancer survivorship is frequent lexicon denoting the posttreatment phase of cancer treatment. The concept of being in transition to survivorship is not well defined. To critically analyze this concept, data sources (n = 63) (from 1985 to 2016) from nursing, sociology, medicine, and psychology were evaluated employing Rodgers evolutionary method. Transition to cancer survivorship is a turning point with a variable time period one passes through after treatment. It is an individualized experience with degrees of liminality, changes, and challenging consequences...
October 20, 2017: ANS. Advances in Nursing Science
https://www.readbyqxmd.com/read/29052841/cognitive-mechanisms-of-inhibitory-control-deficits-in-autism-spectrum-disorder
#10
Lauren M Schmitt, Stormi P White, Edwin H Cook, John A Sweeney, Matthew W Mosconi
BACKGROUND: Inhibitory control deficits are common in autism spectrum disorder (ASD) and associated with more severe repetitive behaviors. Inhibitory control deficits may reflect slower execution of stopping processes, or a reduced ability to delay the onset of behavioral responses in contexts of uncertainty. Previous studies have documented relatively spared stopping processes in ASD, but whether inhibitory control deficits in ASD reflect failures to delay response onset has not been systematically assessed...
October 20, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29050974/liquefaction-of-ground-tire-rubber-at-low-temperature
#11
Xiangyun Cheng, Pan Song, Xinyu Zhao, Zonglin Peng, Shifeng Wang
Low-temperature liquefaction has been investigated as a novel method for recycling ground tire rubber (GTR) into liquid using an environmentally benign process. The liquefaction was carried out at different temperatures (140, 160 and 180 °C) over variable time ranges (2-24 h) by blending the GTR with aromatic oil in a range from 0 to 100 parts per hundred rubber (phr). The liquefied GTR was separated into sol (the soluble fraction of rubber which can be extracted with toluene) and gel fractions (the solid fraction obtained after extraction) to evaluate the reclaiming efficiency...
October 16, 2017: Waste Management
https://www.readbyqxmd.com/read/29038992/-soft-tissue-sarcoma-how-can-posttreatment-alterations-be-distinguished-from-recurrences
#12
REVIEW
I-M Noebauer-Huhmann, T Grieser
The recognition of recurrent soft tissue sarcomas and the differentiation from post-treatment alterations is complex. This article aims to assist the clinical radiologist in the systematic evaluation of local follow-up imaging in soft tissue sarcoma patients. Soft tissue sarcomas encompass multiple entities with different recurrence rates and follow-up intervals. Approved and up to date recommendations are provided, including imaging techniques. The past medical history of the patient, the clinical situation and previous therapies should be known in detail, including surgery, radiation therapy and chemotherapy...
November 2017: Der Radiologe
https://www.readbyqxmd.com/read/29033299/unpredictable-pain-timings-lead-to-greater-pain-when-people-are-highly-intolerant-of-uncertainty
#13
Clémence Bélanger, Bernard Blais Morin, Andréanne Brousseau, Nicolas Gagné, Anne Tremblay, Kathya Daigle, Philippe Goffaux, Guillaume Léonard
BACKGROUND AND PURPOSE: Many psychological factors are known to influence pain perception. Among them, intolerance of uncertainty (IU) may play a key modulating role in situations where uncertainty prevails, especially uncertainty regarding the timing of painful events. The objective of this study was to explore the impact of individual differences in IU on pain perception during predictable and unpredictable stimulation timings. We hypothesized that people with high IU, as opposed to those with low IU, would perceive more pain when the timing of painful stimulations cannot be predicted, as compared to when they can...
October 12, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28974567/relative-and-combined-prognostic-importance-of-on-treatment-mean-and-visit-to-visit-blood-pressure-variability-in-ontarget-and-transcend-patients
#14
RANDOMIZED CONTROLLED TRIAL
Giuseppe Mancia, Helmut Schumacher, Michael Böhm, Josep Redon, Roland E Schmieder, Paolo Verdecchia, Peter Sleight, Koon Teo, Salim Yusuf
In 28 790 patients recruited for the ONTARGET (Ongoing Treatment Alone and in Combination With Ramipril Global End Point Trials) and TRANSCEND (Telmisartan Randomized Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease) trials, we investigated the prognostic value for cardiovascular events (primary outcome) of (1)on-treatment visit-to-visit systolic blood pressure (SBP) variability versus mean SBP and (2) the 2 measures together. SBP variability was measured by the coefficient of variation (CV) of mean SBP to which it was unrelated...
November 2017: Hypertension
https://www.readbyqxmd.com/read/28969761/role-of-nuclear-medicine-for-diagnosing-infection-of-recently-implanted-lower-extremity-arthroplasties
#15
REVIEW
Christopher J Palestro, Charito Love
Infection is an infrequent complication of lower extremity prosthetic joint surgery. Approximately one-third develop within 3 months (early), another third within 1 year (delayed), and the remainder more than 1 year (late) after surgery. Diagnosing prosthetic joint infection, especially in the early postoperative period during the first year, is challenging. Pain is almost always present. The presence of fever is variable, ranging from less than 5% to more than 40% of patients. Leukocytosis is a poor predictor of infection...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28950318/transcatheter-aortic-valve-thrombosis-incidence-clinical-presentation-and-long-term-outcomes
#16
Anna Franzone, Thomas Pilgrim, Alan G Haynes, Jonas Lanz, Masahiko Asami, Fabien Praz, Lorenz Räber, Eva Roost, Bettina Langhammer, Stephan Windecker, Stefan Stortecky
Aims: To assess the incidence, management and long-term outcomes of transcatheter heart valve thrombosis (THVT). Methods and results: Between August 2007 and February 2016, 1396 patients were included in the Bern TAVI Registry and prospectively followed-up through echocardiographic and clinical evaluation. THVT was suspected in case of: (i) a mean transvalvular pressure gradient greater than 20 mmHg at transthoracic echocardiography, or (ii) an increase of more than 50% of the mean transvalvular pressure gradient compared with previous measurements or (iii) new symptoms or signs of heart failure with the presence of thrombus documented by transoesophageal echocardiography or multi-slice computed tomography...
July 29, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28948390/factors-influencing-outcomes-after-cardiac-intervention-in-infants-with-trisomy-13-and-18
#17
Renuka Peterson, Nandini Calamur, Andrew Fiore, Charles Huddleston, Kimberly Spence
Cardiac intervention remains controversial in patients with trisomy 13 and 18 and little is known about factors that may affect outcomes. The goal of this study was to evaluate preoperative factors and surgical approach with respect to outcomes in these patients. Patients with congenital heart disease and trisomy 13 or 18 presenting to our institution from 2004 through 2015 were retrospectively reviewed. Patients were grouped into complete intervention, palliated intervention, and non-intervention. Pre-intervention variables, timing and type of intervention, post-intervention outcomes, and survival were recorded and comparisons were made between the groups...
September 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28936889/t2-relaxometry-mapping-in-demonstrating-layered-uterine-architecture-parameter-optimization-and-utility-in-endometrial-carcinoma-and-adenomyosis-a-feasibility-study
#18
Adarsh Ghosh, Tulika Singh, Rashmi Bagga, Radhika Srinivasan, Veenu Singla, Niranjan Khandelwal
OBJECTIVE: We evaluate the feasibility of T2 relaxometry mapping of the uterus and demonstrate its diagnostic utility in endometrial carcinoma and adenomyosis and discuss the optimum imaging parameters as used in our institute. METHODS: Institute review board approval was obtained and multispin echo (MSE) imaging of the pelvis was done with variable time to echo in three patients, two with endometrial carcinoma and one with adenomyosis. T2 parametric maps and curves were plotted and the T2 times of the diseased endometrium, superficial and deep myometrium were established...
October 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28880279/live-cell-confocal-microscopy-and-quantitative-4d-image-analysis-of-anchor-cell-invasion-through-the-basement-membrane-in-caenorhabditis-elegans
#19
Laura C Kelley, Zheng Wang, Elliott J Hagedorn, Lin Wang, Wanqing Shen, Shijun Lei, Sam A Johnson, David R Sherwood
Cell invasion through basement membrane (BM) barriers is crucial in development, leukocyte trafficking and the spread of cancer. The mechanisms that direct invasion, despite their importance in normal and disease states, are poorly understood, largely because of the inability to visualize dynamic cell-BM interactions in vivo. This protocol describes multichannel time-lapse confocal imaging of anchor-cell invasion in live Caenorhabditis elegans. Methods presented include outline-slide preparation and worm growth synchronization (15 min), mounting (20 min), image acquisition (20-180 min), image processing (20 min) and quantitative analysis (variable timing)...
October 2017: Nature Protocols
https://www.readbyqxmd.com/read/28855895/the-rhizosphere-bacterial-microbiota-of-vitis-vinifera-cv-pinot-noir-in-an-integrated-pest-management-vineyard
#20
Giorgia Novello, Elisa Gamalero, Elisa Bona, Lara Boatti, Flavio Mignone, Nadia Massa, Patrizia Cesaro, Guido Lingua, Graziella Berta
Microorganisms associated with Vitis vinifera (grapevine) can affect its growth, health and grape quality. The aim of this study was to unravel the biodiversity of the bacterial rhizosphere microbiota of grapevine in an integrated pest management vineyard located in Piedmont, Italy. Comparison between the microbial community structure in the bulk and rhizosphere soil (variable: space) were performed. Moreover, the possible shifts of the bulk and rhizosphere soil microbiota according to two phenological stages such as flowering and early fruit development (variable: time) were characterized...
2017: Frontiers in Microbiology
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