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https://www.readbyqxmd.com/read/28623680/what-are-the-incidence-and-factors-associated-with-implant-fracture
#1
Reza Tabrizi, Hossein Behnia, Shahram Taherian, Nima Hesami
PURPOSE: Implant fracture is a serious complication, which leads to treatment failure. The purpose of this study is to estimate the incidence of implant fractures and identify factors associated with them. MATERIALS AND METHODS: In this retrospective cohort study, the sample was derived from 2 implant centers. The predictors were grouped into the following categories: demographic, location of implant, physical characteristic of implant, implant-abutment connection, type of prosthesis, type of retention, and outcome variable (time to implant fracture)...
May 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28616728/the-relationship-of-cancer-characteristics-and-patient-outcome-with-time-to-lung-cancer-diagnosis-after-an-abnormal-screening-ct
#2
Sushilkumar K Sonavane, Paul Pinsky, Jubal Watts, David S Gierada, Reginald Munden, Satinder P Singh, Hrudaya Nath
PURPOSE: The National Lung Screening Trial (NLST) demonstrated a reduction in lung cancer and all-cause mortality with low-dose CT (LDCT) screening. The aim of our study was to examine the time to diagnosis (TTD) of lung cancer in the LDCT arm of the NLST and assess its relationship with cancer characteristics and survival. METHODS: The subjects (N = 462) with a positive baseline screen and subsequent lung cancer diagnosis within 3 years were evaluated by data and image review to confirm the baseline abnormality...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28606624/-impact-of-education-program-and-clinical-posting-in-psychiatry-on-medical-students-stigmatizing-attitudes-towards-psychiatry-and-psychiatric-disorders
#3
N Simon, H Verdoux
OBJECTIVE: The aim of the study was to explore whether a medical student education program and clinical posting in psychiatry had an impact on medical students' stigmatizing attitudes towards psychiatry and psychiatric disorders. METHODS: Medical students from the University of Bordeaux were recruited during their 4-year course at the beginning of the academic education program in psychiatry. Medical students who were concomitantly in a clinical posting in wards of psychiatry or neurology were invited to participate in the study...
June 9, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28585873/a-simple-composite-metric-for-the-assessment-of-glycemic-status-from-continuous-glucose-monitoring-data-implications-for-clinical-practice-and-the-artificial-pancreas
#4
Irl B Hirsch, Andrew K Balo, Kevin Sayer, Arturo Garcia, Bruce A Buckingham, Thomas A Peyser
BACKGROUND: The potential clinical benefits of continuous glucose monitoring (CGM) have been recognized for many years, but CGM is used by a small fraction of patients with diabetes. One obstacle to greater use of the technology is the lack of simplified tools for assessing glycemic control from CGM data without complicated visual displays of data. METHODS: We developed a simple new metric, the personal glycemic state (PGS), to assess glycemic control solely from continuous glucose monitoring data...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28582395/mechanisms-of-generation-of-membrane-potential-resonance-in-a-neuron-with-multiple-resonant-ionic-currents
#5
David M Fox, Hua-An Tseng, Tomasz G Smolinski, Horacio G Rotstein, Farzan Nadim
Neuronal membrane potential resonance (MPR) is associated with subthreshold and network oscillations. A number of voltage-gated ionic currents can contribute to the generation or amplification of MPR, but how the interaction of these currents with linear currents contributes to MPR is not well understood. We explored this in the pacemaker PD neurons of the crab pyloric network. The PD neuron MPR is sensitive to blockers of H- (IH) and calcium-currents (ICa). We used the impedance profile of the biological PD neuron, measured in voltage clamp, to constrain parameter values of a conductance-based model using a genetic algorithm and obtained many optimal parameter combinations...
June 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28578041/microbiota-source-impact-in-vitro-metabolite-colonic-production-and-anti-proliferative-effect-of-spent-coffee-grounds-on-human-colon-cancer-cells-ht-29
#6
Angélica María Hernández-Arriaga, B Dave Oomah, Rocio Campos-Vega
Human gut flora-mediated non-digestible fraction of spent coffee grounds (hgf-NDSCG) was evaluated for its chemopreventive effect and molecular mechanisms involved on human colon adenocarcinoma HT-29 cell survival using two different microbiota source [lean (L) and overweight (OW)]. The source of human gut flora (hgf) (L or OW) affected the pH of hgf-NDSCG only minimally, but linearly reduced those of hgf-inulin. The variability between lean and overweight microbiota was characterized by the metabolism and/or bioaccessibility of different phenolic metabolites, their intermediate and end products as well as by variable time courses...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28572782/timing-of-gun-fire-influences-sprinters-multiple-joint-reaction-times-of-whole-body-in-block-start
#7
Mitsuo Otsuka, Toshiyuki Kurihara, Tadao Isaka
Experienced sprinters are specifically adapted to pre-planning an advanced motor program. Herein, sprinters are able to immediately accelerate their center of mass forward with a whole-body coordinated motion, following a steady state crouched position. We examined the effect of variable timing of reaction signals on multiple joint reaction times (RT) and whole-body RT for specialist sprinters. Twenty well-experienced male sprinters performed five start-dashes from a block start under five variable foreperiod (FP) length conditions (1...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28570587/non-standard-radiotherapy-fractionations-delay-the-time-to-malignant-transformation-of-low-grade-gliomas
#8
Araceli Henares-Molina, Sebastien Benzekry, Pedro C Lara, Marcial García-Rojo, Víctor M Pérez-García, Alicia Martínez-González
Grade II gliomas are slowly growing primary brain tumors that affect mostly young patients. Cytotoxic therapies (radiotherapy and/or chemotherapy) are used initially only for patients having a bad prognosis. These therapies are planned following the "maximum dose in minimum time" principle, i. e. the same schedule used for high-grade brain tumors in spite of their very different behavior. These tumors transform after a variable time into high-grade gliomas, which significantly decreases the patient's life expectancy...
2017: PloS One
https://www.readbyqxmd.com/read/28546040/early-carotid-endarterectomy-provides-a-better-neurological-outcome-in-symptomatic-patients-a-single-center-experience
#9
Gianfranco Varetto, Lorenzo Gibello, Francesca Sperti, Alessandra Trevisan, Edoardo Frola, Paolo Garneri, Pietro Rispoli
INTRODUCTION: Many studies confirmed the role of early carotid endarterectomy to prevent recurrent stroke or transient ischemic attack however the mid-long term neurological benefit is still not completely investigated. The purpose of the study is to evaluate the role of early carotid endarterectomy on the peri and post-operative stroke/death complications of patients with a symptomatic carotid stenosis Material and methods: ninety consecutive patients were referred to our center for a symptomatic carotid stenosis...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28542444/regional-brain-amyloid-%C3%AE-accumulation-associates-with-domain-specific-cognitive-performance-in-parkinson-disease-without-dementia
#10
Rizwan S Akhtar, Sharon X Xie, Yin J Chen, Jacqueline Rick, Rachel G Gross, Ilya M Nasrallah, Vivianna M Van Deerlin, John Q Trojanowski, Alice S Chen-Plotkin, Howard I Hurtig, Andrew D Siderowf, Jacob G Dubroff, Daniel Weintraub
Parkinson disease patients develop clinically significant cognitive impairment at variable times over their disease course, which is often preceded by milder deficits in memory, visuo-spatial, and executive domains. The significance of amyloid-β accumulation to these problems is unclear. We hypothesized that amyloid-β PET imaging by 18F-florbetapir, a radiotracer that detects fibrillar amyloid-β plaque deposits, would identify subjects with global cognitive impairment or poor performance in individual cognitive domains in non-demented Parkinson disease patients...
2017: PloS One
https://www.readbyqxmd.com/read/28539712/betulinic-acid-from-zizyphus-joazeiro-bark-using-focused-microwave-assisted-extraction-and-response-surface-methodology
#11
Fernanda Carolina Sousa Fonseca, Letícia Caribé Batista Reis, Jener David Gonçalves Dos Santos, Carla Rodrigues Cardoso Branco, Sergio Luis da Costa Ferreira, Jorge Mauricio David, Alexsandro Branco
BACKGROUND: The effect of the extraction time (min) and temperature (°C) on the yield of betulinic acid (BA) from Zizyphus joazeiro barks using focused microwave-assisted extraction was investigated. MATERIALS AND METHODS: The ethyl acetate was used as extractor solvent because it was shown to provide a betulinic acid-clean extract. A full two-level statistical factorial design was applied to determine the important effects and interactions of these independent variables upon the yield of BA...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28531419/current-practices-and-experience-of-transition-of-young-people-on-long-term-home-parenteral-nutrition-pn-to-adult-services-a-perspective-from-specialist-centres
#12
E Kyrana, S V Beath, S Gabe, M Small, S Hill
BACKGROUND: There has been an estimated fivefold increase in the number of children receiving parenteral nutrition (PN) at home in the past 10 years with some children approaching the age when they should be referred to adult services whilst still on treatment. Models of care for moving young people onto adult providers of PN at home are not yet well developed, and transition is a potentially dangerous time for young people with complex health needs. METHODS: A questionnaire to ascertain current experience and practices of transition in the context of home PN services was dispatched to 170 consultant gastroenterologists who were members of the British Association of Parenteral and Enteral Nutrition (BAPEN) and also to all 40 members of the Nutrition and IF working group of the British Society of Paediatric Gastroenterology and Nutrition (BSPGHAN)...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28523207/effects-and-satisfaction-of-medical-device-safety-information-reporting-system-using-electronic-medical-record
#13
Hye Jung Jang, Young Deuk Choi, Nam Hyun Kim
OBJECTIVES: This paper describes an evaluation study on the effectiveness of developing an in-hospital medical device safety information reporting system for managing safety information, including adverse incident data related to medical devices, following the enactment of the Medical Device Act in Korea. METHODS: Medical device safety information reports were analyzed for 190 cases that took place prior to the application of a medical device safety information reporting system and during a period when the reporting system was used...
April 2017: Healthcare Informatics Research
https://www.readbyqxmd.com/read/28513268/effects-of-volume-training-on-strength-and-endurance-of-back-muscles-a-randomized-controlled-trial
#14
Leonardo Shigaki, Cynthia Gobbi Alves Araújo, Mariane Guizeline Calderon, Thais Karoline Cezar Costa, Andreo Fernando Aguiar, Leonardo Oliveira Pena Costa, Rubens A da Silva
CONTEXT: Strength/resistance training volume has historically been supported in the American College of Sports Medicine recommendations. However, for the back muscles, exercise prescription related to the number of sets, such as single vs. multiple, is not well established in the literature. OBJECTIVE: The purpose of this study was to compare the effects of two training volumes on strength and endurance of back extensor muscles in untrained young participants, with regard to a repeated measures design...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28507321/pet-imaging-of-dopamine-d2-receptor-internalization-in-schizophrenia
#15
J J Weinstein, E van de Giessen, R J Rosengard, X Xu, N Ojeil, G Brucato, R B Gil, L S Kegeles, M Laruelle, M Slifstein, A Abi-Dargham
Recent genetic, molecular and post-mortem studies suggest impaired dopamine (DA)-D2 receptor (D2R) trafficking in patients with schizophrenia (SZ). Imaging and preclinical studies have shown agonist-induced D2R internalization can be imaged with positron emission tomography (PET) using D2R radiotracers combined with psychostimulant challenge. This is feasible if radiotracer binding is measured when postchallenge DA levels have returned to baseline, following the initial competition phase between DA and radiotracer for binding to D2R...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28482015/a-new-paradigm-for-evaluating-avoidance-escape-motivation
#16
Iku Tsutsui-Kimura, Youcef Bouchekioua, Masaru Mimura, Kenji F Tanaka
Backgrounds: Organisms have evolved to approach pleasurable opportunities and to avoid or escape from aversive experiences. These two distinct motivations are referred to as approach and avoidance/escape motivations and are both considered vital for survival. Despite several recent advances in understanding the neurobiology of motivation, most studies addressed approach but not avoidance/escape motivation. Here we develop a new experimental paradigm to quantify avoidance/escape motivation and examine the pharmacological validity...
May 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28465085/development-of-the-optical-sensor-for-discriminating-isomers-of-fatty-acids-based-on-emissive-network-polymers-composed-of-polyhedral-oligomeric-silsesquioxane
#17
Hayato Narikiyo, Takahiro Kakuta, Hiroki Matsuyama, Masayuki Gon, Kazuo Tanaka, Yoshiki Chujo
It was shown that water-soluble network polymers composed of polyhedral oligomeric silsesquioxane (POSS) had hydrophobic spaces inside the network because of strong hydrophobicity of the cubic silica cage. In this study, the water-soluble POSS network polymers connected with triphenylamine derivatives (TPA-POSS) were synthesized, and their functions as a sensor for discriminating the geometric isomers of fatty acids were investigated. Accordingly, in the photoluminescence spectra, different time-courses of intensity and peak wavelengths of the emission bands were detected from the TPA-POSS-containing solution in the presence of cis- or trans-fatty acids during incubation...
July 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28461029/-uncommon-dermatologic-disorders-triggered-by-radiation-therapy-of-breast-cancer-a-case-series
#18
C Dalmasso, É Tournier, B de Lafontan, A Modesto, F Dalenc, É Chantalat, L Gladieff, E Jouve, C Livideanu, F Izar, V Sibaud
Radiotherapy's main skin toxicities are now well-separated, acute (acute radiation dermatitis) or chronic complications (chronic radiation dermatitis, induced cutaneous carcinoma, aesthetic sequelae). Exceptionally, radiotherapy may induce, by isomorphic reaction or Koebner's phenomenon, some specific dermatosis. In this article, we report five new observations of these unusual complications of radiation therapy, occurring in very variable time after breast irradiation and remaining strictly localized in the irradiated field (cutaneous mastocytosis, Sweet syndrome, lichen planus, vitiligo)...
May 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28447151/rhythms-in-the-endocrine-system-of-fish-a-review
#19
REVIEW
Mairi Cowan, Clara Azpeleta, Jose Fernando López-Olmeda
The environment which living organisms inhabit is not constant and many factors, such as light, temperature, and food availability, display cyclic and predictable variations. To adapt to these cyclic changes, animals present biological rhythms in many of their physiological variables, timing their functions to occur when the possibility of success is greatest. Among these variables, many endocrine factors have been described as displaying rhythms in vertebrates. The aim of the present review is to provide a thorough review of the existing knowledge on the rhythms of the endocrine system of fish by examining the hormones that show rhythmicity, how environmental factors control these rhythms and the variation in the responses of the endocrine system depending on the time of the day...
April 26, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28431947/a-bout-analysis-of-operant-response-disruption
#20
Ryan J Brackney, Timothy H C Cheung, Federico Sanabria
Operant behavior appears to be organized in bouts of responses, whose parameters are differentially sensitive to various manipulations. This study investigated potential differential effects of three forms of operant response disruption-extinction (EXT), non-contingent reinforcement (NCR), and prefeeding (PRE)-on response bouts. In Experiment 1, Wistar Kyoto rats (WKY) were trained on a tandem variable-time (VT) 120s fixed-ratio (FR) 5 schedule of reinforcement; after stability was established, their responding was disrupted for three sessions with one of the three disrupters (EXT, NCR, or PRE)...
April 19, 2017: Behavioural Processes
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