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Pieter van der Bijl, Mand Jh Khidir, Melissa Leung, Dilek Yilmaz, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
BACKGROUND: In heart failure (HF) patients, left ventricular mechanical dispersion (LVMD) reflects heterogeneous mechanical activation of the left ventricle. In HF patients, LVMD can be reduced after CRT. Whether lesser LVMD is associated with improved outcome is unknown. OBJECTIVE: To relate LVMD to long-term prognosis in a large cohort of HF patients after 6 months of cardiac resynchronization therapy (CRT). METHODS: Clinical, echocardiographic and ventricular arrhythmia (VA) data were analyzed from an ongoing registry of HF recipients of CRT...
May 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Alexander Melnikov, Liangjie Chen, Diego Ramirez Venegas, Koneswaran Sivagurunathan, Qiming Sun, Andreas Mandelis, Ignacio Rojas Rodriguez
Single-Frequency Thermal Wave Radar Imaging (SF-TWRI) was introduced and used to obtain quantitative thickness images of coatings on an aluminum block and on polyetherketone, and to image blind subsurface holes in a steel block. In SF-TWR, the starting and ending frequencies of a linear frequency modulation sweep are chosen to coincide. Using the highest available camera frame rate, SF-TWRI leads to a higher number of sampled points along the modulation waveform than conventional lock-in thermography imaging because it is not limited by conventional undersampling at high frequencies due to camera frame-rate limitations...
April 2018: Review of Scientific Instruments
Ellen Stuart-Haëntjens, Hans J De Boeck, Nathan P Lemoine, Pille Mänd, György Kröel-Dulay, Inger K Schmidt, Anke Jentsch, Andreas Stampfli, William R L Anderegg, Michael Bahn, Juergen Kreyling, Thomas Wohlgemuth, Francisco Lloret, Aimée T Classen, Christopher M Gough, Melinda D Smith
Extreme drought is increasing in frequency and intensity in many regions globally, with uncertain consequences for the resistance and resilience of ecosystem functions, including primary production. Primary production resistance, the capacity to withstand change during extreme drought, and resilience, the degree to which production recovers, vary among and within ecosystem types, obscuring generalized patterns of ecological stability. Theory and many observations suggest forest production is more resistant but less resilient than grassland production to extreme drought; however, studies of production sensitivity to precipitation variability indicate that the processes controlling resistance and resilience may be influenced more by mean annual precipitation (MAP) than ecosystem type...
April 27, 2018: Science of the Total Environment
Frank DeVilbiss, Aravinda Mandli, Doraiswami Ramkrishna
Diauxic growth of E. coli is driven by a host of internal, complex regulatory actions. In this classic scenario of cellular control, the cell employs a rational algorithm to modulate its metabolism in a competitive fashion. Cybernetic models of metabolism, whose development now spans three decades, were first formulated to describe regulation of cells in complex, multi-substrate environments. They modeled this scenario using the hypothesis that the formation of the enzymatic machinery is regulated to maximize a return on investment...
April 30, 2018: Biotechnology Progress
Mohammed Y Ansari, Shekhar C Mande
Chaperonins are a subclass of molecular chaperones that assist cellular proteins to fold and assemble into their native shape. Much work has been done on Type I chaperonins, which has elucidated their elegant mechanism. Some debate remains about the details in these mechanisms, but nonetheless the roles of these in helping protein folding have been understood in great depth. In this review we discuss the known functions of atypical Type I chaperonins, highlighting evolutionary aspects that might lead chaperonins to perform alternate functions...
2018: Frontiers in Molecular Biosciences
Jelmer M Samplonius, Lenka Bartošová, Malcolm D Burgess, Andrey V Bushuev, Tapio Eeva, Elena V Ivankina, Anvar B Kerimov, Indrikis Krams, Toni Laaksonen, Marko Mägi, Raivo Mänd, Jaime Potti, János Török, Miroslav Trnka, Marcel E Visser, Herwig Zang, Christiaan Both
Many organisms adjust their reproductive phenology in response to climate change, but phenological sensitivity to temperature may vary between species. For example, resident and migratory birds have vastly different annual cycles, which can cause differential temperature sensitivity at the breeding grounds, and may affect competitive dynamics. Currently, however, adjustment to climate change in resident and migratory birds have been studied separately or at relatively small geographical scales with varying time series durations and methodologies...
April 6, 2018: Global Change Biology
Teri L Hernandez, Archana Mande, Linda A Barbour
With the global rising prevalence of gestational diabetes (GDM), an adaptable, economical approach to nutrition therapy that effectively controls maternal glycemia while promoting normal fetal growth will have far-reaching implications. The conventional focus has been to rigidly limit all types of carbohydrate. While controlling glucose, this approach fosters maternal anxiety and is a primary barrier to adherence. Many mothers substitute fat for carbohydrate, which may unintentionally enhance lipolysis, promote elevated free fatty acids (FFA), and worsen maternal insulin resistance (IR)...
April 18, 2018: Diabetes Research and Clinical Practice
Xujing Li, Anfeng Liu, Mande Xie, Neal N Xiong, Zhiwen Zeng, Zhiping Cai
The quality of service (QoS) regarding delay, lifetime and reliability is the key to the application of wireless sensor networks (WSNs). Data aggregation is a method to effectively reduce the data transmission volume and improve the lifetime of a network. In the previous study, a common strategy required that data wait in the queue. When the length of the queue is greater than or equal to the predetermined aggregation threshold ( N t ) or the waiting time is equal to the aggregation timer ( T t ), data are forwarded at the expense of an increase in the delay...
April 16, 2018: Sensors
Disha Tandon, Mohammed Monzoorul Haque, Saravanan R, Shafiq Shaikh, Sriram P, Ashok Kumar Dubey, Sharmila S Mande
The human gut microbiome contributes to a broad range of biochemical and metabolic functions that directly or indirectly affect human physiology. Several recent studies have indicated that factors like age, geographical location, genetic makeup, and individual health status significantly influence the diversity, stability, and resilience of the gut microbiome. Of the mentioned factors, geographical location (and related dietary/socio-economic context) appears to explain a significant portion of microbiome variation observed in various previously conducted base-line studies on human gut microbiome...
2018: PloS One
Vaagn Andikyan, Annie Kim, Herbert F Gretz, Konstantin Zakashansky, Monica Prasad-Hayes, Ann-Marie Beddoe, Peter Dottino, John Mandeli, Linus Chuang
OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of laparoscopic assessment to determine the likelihood of achieving optimal cytoreduction (OC) in patients undergoing primary debulking surgery (PDS) for ovarian cancer. METHODS: All patients who underwent diagnostic laparoscopy and PDS at our institution from January 2008 to December 2013 were identified. We determined the likelihood of achieving optimal cytoreduction by laparoscopic assessment based on tumor site, pattern of spread, and disease burden...
April 5, 2018: American Journal of Clinical Oncology
Gabrielle Turner-McGrievy, Danielle E Jake-Schoffman, Camelia Singletary, Marquivieus Wright, Anthony Crimarco, Michael D Wirth, Nitin Shivappa, Trisha Mandes, Delia Smith West, Sara Wilcox, Clemens Drenowatz, Andrew Hester, Matthew J McGrievy
BACKGROUND: Wearable physical activity (PA) trackers are becoming increasingly popular for intervention and assessment in health promotion research and practice. The purpose of this article is to present lessons learned from four studies that used commercial PA tracking devices for PA intervention or assessment, present issues encountered with their use, and provide guidelines for determining which tools to use. METHOD: Four case studies are presented that used PA tracking devices (iBitz, Zamzee, FitBit Flex and Zip, Omron Digital Pedometer, Sensewear Armband, and MisFit Flash) in the field-two used the tools for intervention and two used the tools as assessment methods...
April 1, 2018: Health Promotion Practice
Mand J H Khidir, Rachid Abou, Dilek Yilmaz, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
BACKGROUND: Myocardial fibrosis (macroscopic scar or diffuse reactive fibrosis) is one of the determinants of impaired left ventricular (LV) global longitudinal strain (GLS) in heart failure (HF) patients. OBJECTIVES: The present study evaluated the prognostic value of LV GLS in HF patients treated with cardiac resynchronization therapy (CRT). METHODS: 829 HF patients (64.6±10.4 years, 72% men) treated with CRT were included. Prior to CRT implantation, LV GLS was assessed using 2-dimensional speckle tracking echocardiography...
March 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Jihane Mandli, Imane El Fatimi, Narjiss Seddaoui, Aziz Amine
ELISA/immunosensor were developed for a sensitive detection of pork adulteration in meat. Two formats of ELISA were performed. First, an extracted IgG was directly immobilized in the microplate. This assay allowed an identification of 0.01% as level of pork adulteration in 14 h15 min. In order to decrease the time of the assay, a competitive ELISA was developed by immobilizing IgG standard, which compete with the extracted IgG. This assay allowed a detection of 0.1% of pork adulteration in 45 min. Furthermore, two formats of electrochemical immunosensors were elaborated using the electro-entrapment of IgG in polymer modified graphite paste electrode...
July 30, 2018: Food Chemistry
M Alice Shillingsburg, Sarah E Frampton, Sarah C Wymer, Brittany Bartlett
We used procedures established within the mands for information literature to teach two children with autism to mand for social information. Establishing operation trials were alternated with abolishing operation trials to verify the function of the responses as mands. Use of the acquired information was evaluated by examining responding to questions about their social partner. Both participants acquired mands for social information and showed generalization to novel social partners.
March 2018: Behavior Analysis in Practice
Karin Nurme, Enno Merivee, Anne Must, Andrea Di Giulio, Maurizio Muzzi, Ingrid Williams, Marika Mänd
The main purpose of this study was to explain the internal fine structure of potential antennal thermo- and hygroreceptive sensilla, their innervation specifics, and responses of the sensory neurons to thermal and humidity stimuli in an elaterid beetle using focused ion beam scanning electron microscopy and electrophysiology, respectively. Several essential, high temperature induced turning points in the locomotion were determined using automated video tracking. Our results showed that the sensilla under study, morphologically, are identical to the dome-shaped sensilla (DSS) of carabids...
February 2018: Journal of Thermal Biology
Chandrani Das, Chaitanya Mokashi, Sharmila S Mande, Supreet Saini
The food-borne pathogen Salmonella typhimurium is a common cause of infections and diseases in a wide range of hosts. One of the major virulence factors associated to the infection process is flagella, which helps the bacterium swim to its preferred site of infection inside the host, the M-cells (Microfold cells) lining the lumen of the small intestine. The expression of flagellar genes is controlled by an intricate regulatory network. In this work, we investigate two aspects of flagella regulation and assembly: (a) distribution of the number of flagella in an isogenic population of bacteria and (b) dynamics of gene expression post cell division...
2018: Frontiers in Cellular and Infection Microbiology
Christian Waydhas, Markus Baake, Lars Becker, Boris Buck, Helena Düsing, Björn Heindl, Kai Oliver Jensen, Rolf Lefering, Carsten Mand, T Paffrath, Uwe Schweigkofler, Kai Sprengel, Heiko Trentzsch, Bernd Wohlrath, Dan Bieler
BACKGROUND: Trauma team activation (TTA) represents a considerable expenditure of trauma centre resources. It is mainly triggered by field triage criteria. The overall quality of the criteria may be evaluated based on the rate of over- and undertriage. However, there is no gold standard that defines which adult patients truly require a trauma team. The objective of this study was to develop consensus-based criteria defining the necessity for a trauma team. METHODS: A consensus group was formed by trauma specialists experienced in emergency and trauma care with a specific interest in field triage and having previously participated in guideline development...
February 21, 2018: World Journal of Surgery
Colin S Muething, Terry S Falcomata, Raechal Ferguson, Samantha Swinnea, Cayenne Shpall
Children with autism spectrum disorder and other developmental disabilities often exhibit invariant responding (i.e., restricted behavioral repertoires), deficits in communication, and challenging behavior. Approaches demonstrated in the basic and applied literature to increase response variability include extinction, lag schedules of reinforcement, and percentile schedules of reinforcement. Results of basic studies have also indicated that delays to reinforcement often produce increases in response variability...
April 2018: Journal of Applied Behavior Analysis
Krishanu D Baksi, Bhusan K Kuntal, Sharmila S Mande
Realization of the importance of microbiome studies, coupled with the decreasing sequencing cost, has led to the exponential growth of microbiome data. A number of these microbiome studies have focused on understanding changes in the microbial community over time. Such longitudinal microbiome studies have the potential to offer unique insights pertaining to the microbial social networks as well as their responses to perturbations. In this communication, we introduce a web based framework called 'TIME' (Temporal Insights into Microbial Ecology'), developed specifically to obtain meaningful insights from microbiome time series data...
2018: Frontiers in Microbiology
S Shanun Kunnavatana, Katie Wolfe, Alexandra N Aguilar
Functional communication training (FCT) is a common function-based behavioral intervention used to decrease problem behavior by teaching an alternative communication response. Therapists often arbitrarily select the topography of the alternative response, which may influence long-term effectiveness of the intervention. Assessing individual mand topography preference may increase treatment effectiveness and promote self-determination in the development of interventions. This study sought to reduce arbitrary selection of FCT mand topography by determining preference during response training and acquisition for two adults with autism who had no functional communication skills...
May 2018: Behavior Modification
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