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https://www.readbyqxmd.com/read/28274575/relation-of-myocardial-contrast-enhanced-t1-mapping-by-cardiac-magnetic-resonance-to-left-ventricular-reverse-remodeling-after-cardiac-resynchronization-therapy-in-patients-with-nonischemic-cardiomyopathy
#1
Ulas Höke, Mand J H Khidir, Rob J van der Geest, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Myocardial scar is known to be associated with limited left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). However, the impact of diffuse myocardial interstitial fibrosis, as assessed with myocardial T1 mapping cardiac magnetic resonance (CMR), has not been studied in patients with CRT. Therefore, we aimed at evaluating the association between diffuse myocardial interstitial fibrosis, in nonischemic cardiomyopathy patients, and LV reverse remodeling after CRT. A total of 40 patients (61 ± 11 years) with nonischemic cardiomyopathy who underwent CMR before CRT implantation were included...
February 9, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28249491/new-products
#2
Andreas Mandelis
In order to supplement manufacturers' information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
February 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28231486/coded-excitation-waveform-engineering-for-high-frame-rate-synthetic-aperture-ultrasound-imaging
#3
Bahman Lashkari, Kaicheng Zhang, Edem Dovlo, Andreas Mandelis
Coded excitation was initially introduced to ultrasound imaging as a method for enhancing the signal-to-noise ratio (SNR). However, this method was also shown to be helpful in conjunction with synthetic aperture transmission for high frame rate imaging. Recently, we introduced two families of mismatched coded excitations based on frequency modulation chirp and combined frequency modulation and Golay code. Here "mismatched" indicates that the coded excitations generate very small cross-correlations among themselves while each has a very strong autocorrelation...
February 12, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28217309/qrs-duration-versus-morphology-and-survival-after-cardiac-resynchronization-therapy
#4
Mand J H Khidir, Victoria Delgado, Nina Ajmone Marsan, Martin J Schalij, Jeroen J Bax
AIMS: The prognostic implications of QRS duration and morphology in heart failure patients treated with cardiac resynchronization therapy (CRT) remains debated. The present evaluation investigated the association between QRS duration (<150 vs. ≥150 ms) and QRS morphology (left bundle brand block [LBBB] vs. non-LBBB) and long-term prognosis of a large cohort of unselected heart failure patients treated with CRT according to contemporary guidelines. METHODS AND RESULTS: Of 973 heart failure patients treated with CRT (mean age 66...
February 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28198891/photoacoustic-resonance-by-spatial-filtering-of-focused-ultrasound-transducers
#5
Dongyel Kang, Bahman Lashkari, Andreas Mandelis
The effect of a spherically focused ultrasound (US) transducer (TD) on photoacoustic (PA) measurements is analytically investigated using the concept of a virtual point detector. The derived analytical results indicate that the limited numerical aperture (NA) of the PA detector takes on the role of spatial filtering of the induced PA waves, which leads to the occurrence of a peak frequency in the PA spectrum. The mathematical description of this phenomenon is similar to the result of resonance peaks of light propagation in dielectrics...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28179138/the-interdigitating-loop-of-the-enolase-superfamily-as-a-specificity-binding-determinant-or-flying-buttress
#6
REVIEW
Stephen L Bearne
BACKGROUND: Enzymes of the enolase superfamily (ENS) are mechanistically diverse, yet share a common partial reaction (abstraction of the α-proton from a carboxylate substrate). While the catalytic machinery responsible for the deprotonation reaction has been conserved, divergent evolution has led to numerous ENS members that catalyze different overall reactions. This rich functional diversity has made the ENS an excellent model system for developing the approaches necessary to validate enzyme function...
February 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28176418/impact-of-qrs-complex-duration-and-morphology-on-left-ventricular-reverse-remodelling-and-left-ventricular-function-improvement-after-cardiac-resynchronization-therapy
#7
Pieter van der Bijl, Mand Khidir, Melissa Leung, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
AIMS: To evaluate the impact of the interaction of QRS duration and morphology on left ventricular (LV) reverse remodelling and LV functional improvement in heart failure (HF) patients treated with cardiac resynchronization therapy (CRT). METHODS AND RESULTS: From an ongoing registry of HF patients treated with CRT according to contemporary guidelines, demographic, clinical, electrocardiographic (ECG) and echocardiographic characteristics were analysed. Patients were divided according to QRS duration and morphology: <150 ms vs...
February 8, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28147683/new-products
#8
Andreas Mandelis
No abstract text is available yet for this article.
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28128451/teaching-complex-verbal-operants-to-children-with-autism-and-establishing-generalization-using-the-peak-curriculum
#9
Mark R Dixon, Jacqueline Peach, Jacob H Daar, Cindy Penrod
The present study evaluated the feasibility of the PEAK Relational Training System's Generalization Module (Dixon, 2014b) to teach and establish generalization of autoclitic mands, distorted tacts, and creative path finding in three children diagnosed with autism spectrum disorder. Using a multiple-baseline design across behaviors, each participant was provided with differential reinforcement and a least-to-most prompting hierarchy for correct responses to a subset of stimuli, and responses to other similar stimulus sets were probed for emergent generalization...
January 27, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28113418/high-frame-rate-synthetic-aperture-ultrasound-imaging-using-mismatched-coded-excitation-waveform-engineering-a-feasibility-study
#10
Bahman Lashkari, Kaicheng Zhang, Andreas Mandelis
Mismatched coded excitation can be employed to increase the frame rate of synthetic aperture ultrasound imaging. The high auto-correlation and low cross-correlation of the transmitted signals enables the identification and separation of the signal sources at the receiver. Thus, the method provides B-mode imaging with simultaneous transmission from several elements and capability of spatial decoding of the transmitted signals which makes the imaging process equivalent to consecutive transmissions. Each transmission generates its own image and the combination of all the images results in a image with a high lateral resolution...
April 14, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28092684/biallelic-mutations-in-the-3-exonuclease-toe1-cause-pontocerebellar-hypoplasia-and-uncover-a-role-in-snrna-processing
#11
Rea M Lardelli, Ashleigh E Schaffer, Veerle R C Eggens, Maha S Zaki, Stephanie Grainger, Shashank Sathe, Eric L Van Nostrand, Zinayida Schlachetzki, Basak Rosti, Naiara Akizu, Eric Scott, Jennifer L Silhavy, Laura Dean Heckman, Rasim Ozgur Rosti, Esra Dikoglu, Anne Gregor, Alicia Guemez-Gamboa, Damir Musaev, Rohit Mande, Ari Widjaja, Tim L Shaw, Sebastian Markmiller, Isaac Marin-Valencia, Justin H Davies, Linda de Meirleir, Hulya Kayserili, Umut Altunoglu, Mary Louise Freckmann, Linda Warwick, David Chitayat, Susan Blaser, Ahmet Okay Çağlayan, Kaya Bilguvar, Huseyin Per, Christina Fagerberg, Henrik T Christesen, Maria Kibaek, Kimberly A Aldinger, David Manchester, Naomichi Matsumoto, Kazuhiro Muramatsu, Hirotomo Saitsu, Masaaki Shiina, Kazuhiro Ogata, Nicola Foulds, William B Dobyns, Neil C Chi, David Traver, Luigina Spaccini, Stefania Maria Bova, Stacey B Gabriel, Murat Gunel, Enza Maria Valente, Marie-Cecile Nassogne, Eric J Bennett, Gene W Yeo, Frank Baas, Jens Lykke-Andersen, Joseph G Gleeson
Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg(2+)-dependent 3'-end RNases with substrate specificity that is mostly unknown. Pontocerebellar hypoplasia type 7 (PCH7) is a unique recessive syndrome characterized by neurodegeneration and ambiguous genitalia. We studied 12 human families with PCH7, uncovering biallelic, loss-of-function mutations in TOE1, which encodes an unconventional deadenylase...
March 2017: Nature Genetics
https://www.readbyqxmd.com/read/28086870/a-pilot-study-of-a-community-health-agent-led-type-2-diabetes-self-management-program-using-motivational-interviewing-based-approaches-in-a-public-primary-care-center-in-s%C3%A3-o-paulo-brazil
#12
Thais Moura Ribeiro do Valle Nascimento, Ken Resnicow, Marcia Nery, Alexandra Brentani, Elizabeth Kaselitz, Pooja Agrawal, Simanjit Mand, Michele Heisler
BACKGROUND: Rates of noncommunicable diseases (NCDs) such as type 2 diabetes are escalating in low and middle-income countries such as Brazil. Scalable primary care-based interventions are needed to improve self-management and clinical outcomes of adults with diabetes. This pilot study examines the feasibility, acceptability, and outcomes of training community health agents (CHAs) in Motivational Interviewing (MI)-based counseling for patients with poorly controlled diabetes in a primary care center in São Paulo, Brazil...
January 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28040907/new-products
#13
Andreas Mandelis
No abstract text is available yet for this article.
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27994578/comparative-in-silico-analysis-of-butyrate-production-pathways-in-gut-commensals-and-pathogens
#14
Swadha Anand, Harrisham Kaur, Sharmila S Mande
Biosynthesis of butyrate by commensal bacteria plays a crucial role in maintenance of human gut health while dysbiosis in gut microbiome has been linked to several enteric disorders. Contrastingly, butyrate shows cytotoxic effects in patients with oral diseases like periodontal infections and oral cancer. In addition to these host associations, few syntrophic bacteria couple butyrate degradation with sulfate reduction and methane production. Thus, it becomes imperative to understand the distribution of butyrate metabolism pathways and delineate differences in substrate utilization between pathogens and commensals...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27922889/pump-speed-optimization-in-stable-patients-with-a-left-ventricular-assist-device
#15
Lotte E Couperus, Victoria Delgado, Mand J H Khidir, Marijke P M Vester, Meindert Palmen, Marta Fiocco, Eduard R Holman, Laurens F Tops, Robert J M Klautz, Harriëtte F Verwey, Martin J Schalij, Saskia L M A Beeres
Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients. Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored. Hemodynamically stable patients (N=17, age 61 [interquartile range {IQR} 51-66]years; 13 [77%] male) underwent a routine speed ramp test. Echocardiographic images were obtained at incremental speed settings to determine optimal pump speed...
December 2, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27913101/a-growth-opportunity-thoracic-splenosis
#16
Abby Matthews, Michael Chesser, Jasminder Mand, Allen Thomas
No abstract text is available yet for this article.
November 29, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27910436/new-products
#17
Andreas Mandelis
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27850954/1318-biphasic-change-in-serum-potassium-using-potassium-free-replacement-fluid-during-cvvh
#18
William Peppard, Cole Lightfoot, Corinne Bertolaccini, Barrett Mand, Thomas Carver
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836600/a-novel-method-for-sensitive-microrna-detection-electropolymerization-based-doping
#19
Merve Kaplan, Tugba Kilic, Gunnur Guler, Jihane Mandli, Aziz Amine, Mehmet Ozsoz
In the proposed study, for the first time, sensitive electrochemical detection of a breast cancer biomarker microRNA (miRNA), mir-21 was achieved via electropolymerized polypyrrole (PPy) modified pencil graphite electrodes (PPy/PGE). The detection of hybridization of electrochemically doped probe miRNA, antimir-21, with its complementary target, mir-21 was monitored by either electrochemical impedance spectroscopy (EIS) via comparison of charge transfer resistance (Rct) values before and after hybridization or by electrochemical reduction signal of an hybridization indicator, Meldola's blue (MDB)...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27821311/breastfeeding-and-motor-development-a-longitudinal-cohort-study
#20
Tegan Grace, Wendy Oddy, Max Bulsara, Beth Hands
BACKGROUND: While there is a large body of work supporting the importance of early feeding practices on cognitive, immunity, behavioural and mental outcomes, few longitudinal studies have focused on motor development. The relationship between duration of breast feeding and motor development outcomes at 10, 14, and 17years were examined. METHODS: Data were obtained from the Western Australian Pregnancy (Raine) Study. There were 2868 live births recorded and children were examined for motor proficiency at 10 (M=10...
January 2017: Human Movement Science
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