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https://www.readbyqxmd.com/read/29319190/effects-of-response-preference-on-resistance-to-change
#1
Joel E Ringdahl, Wendy K Berg, David P Wacker, Kayla Crook, Maggie A Molony, Kristina K Vargo, Jodi E Neurnberger, Karla Zabala, Christopher J Taylor
Treatments based on differential reinforcement of alternative behavior, such as functional communication training, are widely used. Research regarding the maintenance of related treatment effects is limited. Nevin and Wacker (2013) provided a conceptual framework, rooted in behavioral momentum theory, for the study of treatment maintenance that addressed two components: (a) reemergence of problem behavior, and (b) continued expression of appropriate behavior. In the few studies on this topic, focus has been on variables impacting the reemergence of problem behavior, with fewer studies evaluating the persistence of appropriate behavior...
January 10, 2018: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/29318608/functional-analysis-and-treatment-of-problem-behavior-related-to-mands-for-rearrangement
#2
REVIEW
Mariana Torres-Viso, Craig W Strohmeier, Jennifer R Zarcone
This study is a systematic replication of a functional analysis (FA) of the relation between mands and problem behavior. We extended treatment approaches for this problem behavior function, and describe the treatment of problem behavior related to mands for rearrangement demonstrated by a 12-year-old girl with autism spectrum disorder and Smith-Magenis syndrome. The mands consisted of requests for others to change their body positioning or proximity, or rearrange items back to their original position. An FA confirmed the relation between problem behavior and mand compliance, and functional communication training with extinction decreased problem behavior and increased functional communication responses...
January 10, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29317520/atm-directs-dna-damage-responses-and-proteostasis-via-genetically-separable-pathways
#3
Ji-Hoon Lee, Michael R Mand, Chung-Hsuan Kao, Yi Zhou, Seung W Ryu, Alicia L Richards, Joshua J Coon, Tanya T Paull
The protein kinase ATM is a master regulator of the DNA damage response but also responds directly to oxidative stress. Loss of ATM causes ataxia telangiectasia, a neurodegenerative disorder with pleiotropic symptoms that include cerebellar dysfunction, cancer, diabetes, and premature aging. We genetically separated the activation of ATM by DNA damage from that by oxidative stress using separation-of-function mutations. We found that deficient activation of ATM by the Mre11-Rad50-Nbs1 complex and DNA double-strand breaks resulted in loss of cell viability, checkpoint activation, and DNA end resection in response to DNA damage...
January 9, 2018: Science Signaling
https://www.readbyqxmd.com/read/29289162/new-products
#4
Andreas Mandelis
In order to supplement manufacturers' information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29216746/employing-a-fixed-lean-multiple-schedule-in-the-treatment-of-challenging-behavior-for-children-with-autism-spectrum-disorder
#5
Shaji S Haq, Wendy Machalicek, S Andrew Garbacz, Christine Drew
Despite its utility, there is limited applied research on employing fixed-lean (FL) schedules of reinforcement in treatment packages to address challenging behavior. One potential reason is that abrupt shifts to terminal schedules of reinforcement have been associated with immediate increases in challenging behavior before subsiding to clinically acceptable levels. The purpose of the present study was to (a) provide evidence demonstrating the utility of a FL multiple schedule (MS) in the treatment of challenging behavior in applied settings, (b) examine the potential effects of alternative stimuli on challenging behavior during a FL MS, and (c) assess the social validity of this treatment package with participants and caregivers...
December 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/29205605/coaching-parents-to-assess-and-treat-self-injurious-behaviour-via-telehealth
#6
S S Benson, A F Dimian, M Elmquist, J Simacek, J J McComas, F J Symons
The application of telehealth technology to conduct functional analysis (FA) and functional communication training (FCT) is emerging for children with developmental disabilities and behaviour support needs. The current study was designed to extend FA + FCT for self-injurious behaviour by using telehealth in home with parents as interventionists receiving real-time remote coaching. Two families with school-aged boys with developmental disabilities associated with intellectual disability participated, one with cerebral palsy and the other with autism spectrum disorder...
December 5, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29170495/first-trimester-vaginal-microbiome-diversity-a-potential-indicator-of-preterm-delivery-risk
#7
Mohammed Monzoorul Haque, Mitali Merchant, Pinna Nishal Kumar, Anirban Dutta, Sharmila S Mande
Preterm birth is a leading cause of global neonate mortality. Hospitalization costs associated with preterm deliveries present a huge economic burden. Existing physical/biochemical markers for predicting preterm birth risk are mostly suited for application at mid/late pregnancy stages, thereby leaving very short time (between diagnosis and delivery) for adopting appropriate intervention strategies. Recent studies indicating correlations between pre/full-term delivery and the composition of vaginal microbiota in pregnant women have opened new diagnostic possibilities...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29169788/stellate-ganglion-block-as-rescue-therapy-in-refractory-vasospasm-after-subarachnoid-hemorrhage
#8
J Sánchez Arguiano, M A Hernández-Hernández, R A Jáuregui Solórzano, S Maldonado-Vega, A González Mandly, J Burón Mediavilla
No abstract text is available yet for this article.
November 20, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29169242/lag-schedules-and-functional-communication-training-persistence-of-mands-and-relapse-of-problem-behavior
#9
Terry S Falcomata, Colin S Muething, Bryant C Silbaugh, Summer Adami, Katherine Hoffman, Cayenne Shpall, Joel E Ringdahl
We evaluated the effects of lag schedules of reinforcement and functional communication training (FCT) on mand variability and problem behavior in two children with autism spectrum disorder. Specifically, we implemented FCT with increasing lag schedules and compared its effects on problem behavior with baseline conditions. The results showed that both participants exhibited low rates of problem behavior during treatment relative to baseline during and following schedule thinning (up to a Lag 5 schedule arrangement)...
November 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/29163445/in-silico-analysis-of-putrefaction-pathways-in-bacteria-and-its-implication-in-colorectal-cancer
#10
Harrisham Kaur, Chandrani Das, Sharmila S Mande
Fermentation of undigested proteins in human gastrointestinal tract (gut) by the resident microbiota, a process called bacterial putrefaction, can sometimes disrupt the gut homeostasis. In this process, essential amino acids (e.g., histidine, tryptophan, etc.) that are required by the host may be utilized by the gut microbes. In addition, some of the products of putrefaction, like ammonia, putrescine, cresol, indole, phenol, etc., have been implicated in the disease pathogenesis of colorectal cancer (CRC). We have investigated bacterial putrefaction pathways that are known to be associated with such metabolites...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29133866/gastric-microbiome-of-indian-patients-with-helicobacter-pylori-infection-and-their-interaction-networks
#11
Anubhav Das, Verima Pereira, Shruti Saxena, Tarini Shankar Ghosh, D Anbumani, Satyabrata Bag, Bhabatosh Das, G Balakrish Nair, Philip Abraham, Sharmila S Mande
The gastric microbiome is suspected to have a role in the causation of diseases by Helicobacter pylori. Reports on their relative abundance vis-à-vis H. pylori are available from various ethnic and geographic groups, but little is known about their interaction patterns. Endoscopic mucosal biopsy samples from the gastric antrum and corpus of 39 patients with suspected H. pylori infection were collected and microbiomes were analyzed by 16S rDNA profiling. Four groups of samples were identified, which harbored Helicobacter as well as a diverse group of bacteria including Lactobacillus, Halomonas and Prevotella...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29128083/evolution-of-hepatocellular-carcinoma-epidemiology-in-c%C3%A3-te-d-ivoire
#12
REVIEW
Judith Didi-Kouko Coulibaly, Mireille Yeboua, Alphonsine Kouassi Mbengue, Emile Allah Kouadio, Henriette Anzouan-Kacou Kissi, Allah Yves-Omer Binan, Marie-Jeanne Lohoues Kouacou, Alain Attia, Dominique Yao N'Drin, Toussaint Toutou, Innocent Adoubi, Pascal Pineau
INTRODUCTION: Hepatocellular carcinoma is a major concern for Public health in West Africa. In Côte d'Ivoire, the bulk of our knowledge stems from studies conducted decades ago. Our aim was, thus, to assess whether the epidemiological features of this tumor changed recently. METHODS: Records from 863 patients diagnosed between 2007 and 2014 were analyzed. RESULTS: We observed major drifts concerning hepatocellular carcinoma with regards to the 1970-1980 period...
November 8, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29031415/usefulness-of-the-crt-score-for-shared-decision-making-in-cardiac-resynchronization-therapy-in-patients-with-a-left-ventricular-ejection-fraction-of-%C3%A2-35
#13
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29021932/an-evaluation-of-lag-schedules-of-reinforcement-during-functional-communication-training-effects-on-varied-mand-responding-and-challenging-behavior
#14
Summer Adami, Terry S Falcomata, Colin S Muething, Katherine Hoffman
We evaluated the effects of lag schedules of reinforcement during functional communication training (FCT) on the varied use of mands and challenging behavior by two individuals diagnosed with autism. Specifically, we compared the effects of Lag 0 and Lag 1 schedules of reinforcement during FCT. The results showed that each participant exhibited increases in varied mand responding during FCT with the Lag 1 schedule of reinforcement relative to Lag 0; challenging behavior remained low during both FCT lag conditions relative to baseline...
September 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/28991419/synergistic-interactions-between-a-variety-of-insecticides-and-an-ebi-fungicide-in-dietary-exposures-of-bumble-bees-bombus-terrestris-l
#15
Risto Raimets, Reet Karise, Marika Mänd, Tanel Kaart, Sally Ponting, Jimao Song, James E Cresswell
BACKGROUND: In recent years, concern has been raised over honey bee colony losses, and also among wild bees there is evidence for extinctions and range contractions in Europe and North America. Pesticides have been proposed as a potential cause of this decline. Bees are exposed simultaneously to variety of agrochemicals, which may cause synergistically detrimental impacts, which are incompletely understood. We investigated the toxicity of the fungicide imazalil in mixture with four common insecticides: fipronil (phenylpyrazoid); cypermethrin (pyrethroid); thiamethoxam; and imidacloprid (neonicotinoids)...
October 9, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28964242/new-products
#16
Andreas Mandelis
In order to supplement manufacturers' information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
September 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28956673/effects-of-a-lag-schedule-of-reinforcement-with-progressive-time-delay-on-topographical-mand-variability-in-children-with-autism
#17
Bryant C Silbaugh, Terry S Falcomata, Raechal H Ferguson
OBJECTIVE: Evaluate the effects of a Lag 1 schedule of reinforcement and progressive time delay (TD) on topographical mand variability in children with autism. METHODS: Using single-subject design methodology, a multiple baseline across behaviors with embedded reversal design was employed. During Lag 0, reinforcement was delivered contingent on any independent instances of manding. During Lag 1 + TD, prompts were faded and reinforcement was delivered contingent on independent or prompted variant mand topographies...
September 28, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28951022/influence-of-aging-on-level-and-layer-specific-left-ventricular-longitudinal-strain-in-subjects-without-structural-heart-disease
#18
Rachid Abou, Melissa Leung, Mand J H Khidir, Ron Wolterbeek, Martin J Schalij, Nina Ajmone Marsan, Jeroen J Bax, Victoria Delgado
Values for level- (apical, mid, and basal) and layer-based (endocardial, mid-myocardial, and epicardial) left ventricular (LV) longitudinal strain across age are scarce. The present study evaluates the effect of aging on level- and layer-specific LV longitudinal strain in subjects without structural heart disease. A total of 408 subjects (mean age 58 years [range 16 to 91]; 49% men) were evaluated retrospectively. Subjects were divided into equal groups based on age and gender. Subjects with evidence of structural heart disease or arrhythmias were excluded...
December 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28944244/inherited-2q23-1-microdeletions-involving-the-mbd5-locus
#19
Shereen Tadros, Rubin Wang, Jonathan J Waters, Christine Waterman, Amanda L Collins, Morag N Collinson, Joo W Ahn, Dragana Josifova, Ravi Chetan, Ajith Kumar
BACKGROUND: Microdeletions of 2q23.1 disrupting MBD5 and loss of function mutations of MBD5 cause MBD5-Associated Neurodevelopmental disorders (MAND). Nearly all reported patients have been isolated cases of de novo origin. METHODS: This study investigates three families with inherited MBD5 mutations from three different Regional Genetics Centres in the UK. RESULTS: Two of the parents in the study had MBD5 deletions in a mosaic form. The parent with an MBD5 deletion in an apparently nonmosaic form has a psychiatric disorder in the absence of developmental delay or dysmorphism...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28901545/teaching-children-with-autism-to-respond-to-disguised-mands
#20
Adel C Najdowski, Ryan Bergstrom, Jonathan Tarbox, Megan St Clair
Children with autism spectrum disorder (ASD) often have difficulty inferring the private events of others, including private verbal behavior (e.g., thoughts), private emotional responses, and private establishing operations, often referred to as "perspective taking" by the general psychology community. Children with ASD also have difficulty responding to disguised mands. Skinner's description of the "disguised mand" is verbal behavior wherein the speaker's mand directly describes neither its reinforcer nor the corresponding establishing operations...
October 2017: Journal of Applied Behavior Analysis
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