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https://www.readbyqxmd.com/read/29133866/gastric-microbiome-of-indian-patients-with-helicobacter-pylori-infection-and-their-interaction-networks
#1
Anubhav Das, Verima Pereira, Shruti Saxena, Tarini Shankar Ghosh, D Anbumani, Satyabrata Bag, Bhabatosh Das, G Balakrish Nair, Philip Abraham, Sharmila S Mande
The gastric microbiome is suspected to have a role in the causation of diseases by Helicobacter pylori. Reports on their relative abundance vis-à-vis H. pylori are available from various ethnic and geographic groups, but little is known about their interaction patterns. Endoscopic mucosal biopsy samples from the gastric antrum and corpus of 39 patients with suspected H. pylori infection were collected and microbiomes were analyzed by 16S rDNA profiling. Four groups of samples were identified, which harbored Helicobacter as well as a diverse group of bacteria including Lactobacillus, Halomonas and Prevotella...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29128083/evolution-of-hepatocellular-carcinoma-epidemiology-in-c%C3%A3-te-d-ivoire
#2
REVIEW
Judith Didi-Kouko Coulibaly, Mireille Yeboua, Alphonsine Kouassi Mbengue, Emile Allah Kouadio, Henriette Anzouan-Kacou Kissi, Allah Yves-Omer Binan, Marie-Jeanne Lohoues Kouacou, Alain Attia, Dominique Yao N'Drin, Toussaint Toutou, Innocent Adoubi, Pascal Pineau
INTRODUCTION: Hepatocellular carcinoma is a major concern for Public health in West Africa. In Côte d'Ivoire, the bulk of our knowledge stems from studies conducted decades ago. Our aim was, thus, to assess whether the epidemiological features of this tumor changed recently. METHODS: Records from 863 patients diagnosed between 2007 and 2014 were analyzed. RESULTS: We observed major drifts concerning hepatocellular carcinoma with regards to the 1970-1980 period...
November 8, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29031415/usefulness-of-the-crt-score-for-shared-decision-making-in-cardiac-resynchronization-therapy-in-patients-with-a-left-ventricular-ejection-fraction-of-%C3%A2-35
#3
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29021932/an-evaluation-of-lag-schedules-of-reinforcement-during-functional-communication-training-effects-on-varied-mand-responding-and-challenging-behavior
#4
Summer Adami, Terry S Falcomata, Colin S Muething, Katherine Hoffman
We evaluated the effects of lag schedules of reinforcement during functional communication training (FCT) on the varied use of mands and challenging behavior by two individuals diagnosed with autism. Specifically, we compared the effects of Lag 0 and Lag 1 schedules of reinforcement during FCT. The results showed that each participant exhibited increases in varied mand responding during FCT with the Lag 1 schedule of reinforcement relative to Lag 0; challenging behavior remained low during both FCT lag conditions relative to baseline...
September 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/28991419/synergistic-interactions-between-a-variety-of-insecticides-and-an-ebi-fungicide-in-dietary-exposures-of-bumble-bees-bombus-terrestris-l
#5
Risto Raimets, Reet Karise, Marika Mänd, Tanel Kaart, Sally Ponting, Jimao Song, James E Cresswell
BACKGROUND: In recent years, concern has been raised over honey bee colony losses, and also among wild bees there is evidence for extinctions and range contractions in Europe and North America. Pesticides have been proposed as a potential cause of this decline. Bees are exposed simultaneously to variety of agrochemicals, which may cause synergistically detrimental impacts, which are incompletely understood. We investigated the toxicity of the fungicide imazalil in mixture with four common insecticides: fipronil (phenylpyrazoid); cypermethrin (pyrethroid); thiamethoxam; and imidacloprid (neonicotinoids)...
October 9, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28964242/new-products
#6
Andreas Mandelis
In order to supplement manufacturers' information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
September 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28956673/effects-of-a-lag-schedule-of-reinforcement-with-progressive-time-delay-on-topographical-mand-variability-in-children-with-autism
#7
Bryant C Silbaugh, Terry S Falcomata, Raechal H Ferguson
OBJECTIVE: Evaluate the effects of a Lag 1 schedule of reinforcement and progressive time delay (TD) on topographical mand variability in children with autism. METHODS: Using single-subject design methodology, a multiple baseline across behaviors with embedded reversal design was employed. During Lag 0, reinforcement was delivered contingent on any independent instances of manding. During Lag 1 + TD, prompts were faded and reinforcement was delivered contingent on independent or prompted variant mand topographies...
September 28, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28951022/influence-of-aging-on-level-and-layer-specific-left-ventricular-longitudinal-strain-in-subjectswithout-structural-heart-disease
#8
Rachid Abou, Melissa Leung, Mand J H Khidir, Ron Wolterbeek, Martin J Schalij, Nina Ajmone Marsan, Jeroen J Bax, Victoria Delgado
Values for level- (apical, mid, and basal) and layer-based (endocardial, mid-myocardial, and epicardial) left ventricular (LV) longitudinal strain across age are scarce. The present study evaluates the effect of aging on level- and layer-specific LV longitudinal strain in subjects without structural heart disease. A total of 408 subjects (mean age 58 years [range 16 to 91]; 49% men) were evaluated retrospectively. Subjects were divided into equal groups based on age and gender. Subjects with evidence of structural heart disease or arrhythmias were excluded...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28944244/inherited-2q23-1-microdeletions-involving-the-mbd5-locus
#9
Shereen Tadros, Rubin Wang, Jonathan J Waters, Christine Waterman, Amanda L Collins, Morag N Collinson, Joo W Ahn, Dragana Josifova, Ravi Chetan, Ajith Kumar
BACKGROUND: Microdeletions of 2q23.1 disrupting MBD5 and loss of function mutations of MBD5 cause MBD5-Associated Neurodevelopmental disorders (MAND). Nearly all reported patients have been isolated cases of de novo origin. METHODS: This study investigates three families with inherited MBD5 mutations from three different Regional Genetics Centres in the UK. RESULTS: Two of the parents in the study had MBD5 deletions in a mosaic form. The parent with an MBD5 deletion in an apparently nonmosaic form has a psychiatric disorder in the absence of developmental delay or dysmorphism...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28901545/teaching-children-with-autism-to-respond-to-disguised-mands
#10
Adel C Najdowski, Ryan Bergstrom, Jonathan Tarbox, Megan St Clair
Children with autism spectrum disorder (ASD) often have difficulty inferring the private events of others, including private verbal behavior (e.g., thoughts), private emotional responses, and private establishing operations, often referred to as "perspective taking" by the general psychology community. Children with ASD also have difficulty responding to disguised mands. Skinner's description of the "disguised mand" is verbal behavior wherein the speaker's mand directly describes neither its reinforcer nor the corresponding establishing operations...
October 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28898772/are-pesticide-residues-in-honey-related-to-oilseed-rape-treatments
#11
Reet Karise, Risto Raimets, Vadims Bartkevics, Iveta Pugajeva, Priit Pihlik, Indrek Keres, Ingrid H Williams, Haldja Viinalass, Marika Mänd
Pesticide treatments before and during the flowering of honey bee forage crops may lead to residues in honey. In northern regions oilseed rape belongs to the main forage crops that is mostly cultivated by means of intensive agriculture, including several pesticide treatments. However, in addition to the focal forage crops, pesticides from non-forage crops can spread to wild flowers around fields, and thus the residues in honey would reflect the whole range of pesticides used in the agricultural landscape. The aim of our study was to clarify which currently used pesticides are present in honey gathered from heterogeneous agricultural landscapes after the end of flowering of oilseed crops...
September 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28874590/discovery-of-peptide-ligands-through-docking-and-virtual-screening-at-nicotinic-acetylcholine-receptor-homology-models
#12
Abba E Leffler, Alexander Kuryatov, Henry A Zebroski, Susan R Powell, Petr Filipenko, Adel K Hussein, Juliette Gorson, Anna Heizmann, Sergey Lyskov, Richard W Tsien, Sébastien F Poget, Annette Nicke, Jon Lindstrom, Bernardo Rudy, Richard Bonneau, Mandë Holford
Venom peptide toxins such as conotoxins play a critical role in the characterization of nicotinic acetylcholine receptor (nAChR) structure and function and have potential as nervous system therapeutics as well. However, the lack of solved structures of conotoxins bound to nAChRs and the large size of these peptides are barriers to their computational docking and design. We addressed these challenges in the context of the α4β2 nAChR, a widespread ligand-gated ion channel in the brain and a target for nicotine addiction therapy, and the 19-residue conotoxin α-GID that antagonizes it...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28863701/new-products
#13
Andreas Mandelis
In order to supplement manufacturers' information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28764531/new-products
#14
Andreas Mandelis
In order to supplement manufacturers' information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
July 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28761465/absence-of-asymptomatic-malaria-infection-in-a-cross-sectional-study-in-iranshahr-district-iran-under-elimination-programmes
#15
Sakineh Pirahmadi, Sedigheh Zakeri, Ahmad Raeisi
BACKGROUND: Asymptomatic malaria infection provides a reservoir of parasites, causing the persistence of malaria transmission. It accounts an important challenge for successful management of the control, elimination, and eradication programmes in any malaria-endemic region. This investigation was designed to assess the presence and the prevalence of asymptomatic carriers in Iranshahr district of Sistan and Baluchistan Province (2013-2014), with a considerable population movement, during the malaria elimination phase in Iran...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28732056/inferring-microbial-interactions-in-thermophilic-and-mesophilic-anaerobic-digestion-of-hog-waste
#16
Grace Tzun-Wen Shaw, An-Chi Liu, Chieh-Yin Weng, Chu-Yang Chou, Daryi Wang
Anaerobic digestion (AnD) is a microbiological process that converts organic waste materials into biogas. Because of its high methane content, biogas is a combustible energy source and serves as an important environmental technology commonly used in the management of animal waste generated on large animal farms. Much work has been done on hardware design and process engineering for the generation of biogas. However, little is known about the complexity of the microbiology in this process. In particular, how microbes interact in the digester and eventually breakdown and convert organic matter into biogas is still regarded as a "black box...
2017: PloS One
https://www.readbyqxmd.com/read/28667989/new-products
#17
Andreas Mandelis
In order to supplement manufacturers' information, this Department will welcome the submission by our readers of brief communications reporting measurements on the physical properties of materials which supersede earlier data or suggest new research applications.
June 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28649408/ser-thr-protein-kinase-prkc-mediated-regulation-of-groel-is-critical-for-biofilm-formation-in-bacillus-anthracis
#18
Gunjan Arora, Andaleeb Sajid, Richa Virmani, Anshika Singhal, C M Santosh Kumar, Neha Dhasmana, Tanya Khanna, Abhijit Maji, Richa Misra, Virginie Molle, Dörte Becher, Ulf Gerth, Shekhar C Mande, Yogendra Singh
PrkC is a conserved Ser/Thr protein kinase encoded in Bacillus anthracis genome. PrkC is shown to be important for B. anthracis pathogenesis, but little is known about its other functions and phosphorylated substrates. Systemic analyses indicate the compelling role of PrkC in phosphorylating multiple substrates, including the essential chaperone GroEL. Through mass spectrometry, we identified that PrkC phosphorylates GroEL on six threonine residues that are distributed in three canonical regions. Phosphorylation facilitates the oligomerization of GroEL to the physiologically active tetradecameric state and increases its affinity toward the co-chaperone GroES...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28630616/a-plant-based-diet-for-overweight-and-obesity-prevention-and-treatment
#19
REVIEW
Gabrielle Turner-McGrievy, Trisha Mandes, Anthony Crimarco
The goal of this paper is to review the evidence related to the effect of plant-based dietary patterns on obesity and weight loss, including both observational and intervention trials. Literature from plant-based diets (PBDs) epidemiological and clinical trial research was used to inform this review. In addition, data on dietary quality, adherence, and acceptability were evaluated and are presented. Both clinical trials and observational research indicate an advantage to adoption of PBDs for preventing overweight and obesity and promoting weight loss...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28630214/patient-derived-interstitial-fluids-and-predisposition-to-aggressive-sporadic-breast-cancer-through-collagen-remodeling-and-inactivation-of-p53
#20
Timothy C Kenny, Hank Schmidt, Kerin Adelson, Yujin Hoshida, Anna P Koh, Nagma Shah, John Mandeli, Jess Ting, Doris Germain
Purpose: Despite the fact that interstitial fluid (IF) represents a third of our body fluid, it is the most poorly understood body fluid in medicine. Increased IF pressure is thought to result from the increased deposition of extracellular matrix in the affected tissue preventing its reabsorption. In the cancer field, increased rigidity surrounding a cancerous mass remains the main reason that palpation and radiologic examination, such as mammography, are used for cancer detection. While the pressure produced by IF has been considered, the biochemical composition of IF has not been considered in its effect on tumors...
September 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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