Suna Liu, Pu Yang, Shiyong Peng, Chenghao Zhu, Shengyu Cao, Jian Li, Jiangtao Sun
A gold-catalyzed sequential annulation reaction to prepare 3,4-fused bicyclic furan compounds has been realized by employing 2-(1-alkynyl)-2-alken-1-ones and 1,3,5-triazines as the starting materials under mild reaction conditions. This protocol features multiple bond formation in a single operation with the incorporation of two nitrogen and two carbon atoms into the final products. A mechanistic investigation reveals that the sequential annulations involved an unprecedented stepwise [3+2+2]-cycloaddition.
January 5, 2017: Chemical Communications: Chem Comm