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https://www.readbyqxmd.com/read/28346878/how-appropriate-are-the-english-language-test-requirements-for-non-uk-trained-nurses-a-qualitative-study-of-spoken-communication-in-uk-hospitals
#1
Carole Sedgwick, Mark Garner
BACKGROUND: Non-native speakers of English who hold nursing qualifications from outside the UK are required to provide evidence of English language competence by achieving a minimum overall score of Band 7 on the International English Language Testing System (IELTS) academic test. OBJECTIVES: To describe the English language required to deal with the daily demands of nursing in the UK. To compare these abilities with the stipulated levels on the language test. DESIGN: A tracking study was conducted with 4 nurses, and focus groups with 11 further nurses...
March 6, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28346757/commentary-extraordinary-environments-extreme-neuroplasticity-and-mental-disorder-reflections-on-pathways-from-adversity-to-mental-disorder-prompted-by-mccrory-gerin-and-viding-2017
#2
Edmund J S Sonuga-Barke
Neuroplasticity, the brain's capacity to be shaped in response to environmental experience, has been claimed to resemble a double-edged sword - potentiating growth and healing when individuals are exposed to normative, benign or therapeutic environments on the one hand, mediating mental disorder development in those exposed to adversity, on the other. However, questions about the scope and limits of neuroplasticity and, especially, its clinical significance, remain unanswered.
April 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28346697/car-t-cell-therapy-for-pancreatic-cancer
#3
REVIEW
Carl J DeSelm, Zachary E Tano, Anna M Varghese, Prasad S Adusumilli
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells pose hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T-cell therapy...
March 27, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28346511/is-manure-an-alternative-to-topsoil-in-road-embankment-restoration
#4
Begoña Peco, Desirée Rivera, Pablo García-Palacios, Berta M Jauregui
One of the main steps in road and railway embankment restoration is the spreading of previously removed topsoil, which provides an input of seeds, organic matter and microorganisms and encourages the establishment of a vegetation cover, essential to stabilise the embankment and blend it with the landscape. However, topsoil is a scarce resource, prompting the search for economic alternatives with similar results. The present study compares the results of spreading topsoil with an organic amendment (manure) for the soil's physico-chemical properties, erosion resistance and microbial activity, floristic richness and composition, and bare soil cover...
2017: PloS One
https://www.readbyqxmd.com/read/28346490/effect-of-hiv-and-malaria-parasites-co-infection-on-immune-hematological-profiles-among-patients-attending-anti-retroviral-treatment-art-clinic-in-infectious-disease-hospital-kano-nigeria
#5
Feyisayo Ebenezer Jegede, Tinuade Ibijoke Oyeyi, Surajudeen Abiola Abdulrahman, Henry Akwen Mbah, Titilope Badru, Chinedu Agbakwuru, Oluwasanmi Adedokun
BACKGROUND: Human immunodeficiency virus (HIV) and malaria co-infection may present worse health outcomes in the tropics. Information on HIV/malaria co-infection effect on immune-hematological profiles is critical for patient care and there is a paucity of such data in Nigeria. OBJECTIVE: To evaluate immune-hematological profiles among HIV infected patients compared to HIV/malaria co-infected for ART management improvement. METHODS: This was a cross sectional study conducted at Infectious Disease Hospital, Kano...
2017: PloS One
https://www.readbyqxmd.com/read/28346441/altering-the-threshold-of-an-excitable-signal-transduction-network-changes-cell-migratory-modes
#6
Yuchuan Miao, Sayak Bhattacharya, Marc Edwards, Huaqing Cai, Takanari Inoue, Pablo A Iglesias, Peter N Devreotes
The diverse migratory modes displayed by different cell types are generally believed to be idiosyncratic. Here we show that the migratory behaviour of Dictyostelium was switched from amoeboid to keratocyte-like and oscillatory modes by synthetically decreasing phosphatidylinositol-4,5-bisphosphate levels or increasing Ras/Rap-related activities. The perturbations at these key nodes of an excitable signal transduction network initiated a causal chain of events: the threshold for network activation was lowered, the speed and range of propagating waves of signal transduction activity increased, actin-driven cellular protrusions expanded and, consequently, the cell migratory mode transitions ensued...
March 27, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28346121/can-memories-of-traumatic-experiences-or-addiction-be-erased-or-modified-a-critical-review-of-research-on-the-disruption-of-memory-reconsolidation-and-its-applications
#7
Michael Treanor, Lily A Brown, Jesse Rissman, Michelle G Craske
Recent research suggests that the mere act of retrieving a memory can temporarily make that memory vulnerable to disruption. This process of "reconsolidation" will typically restabilize the neural representation of the memory and foster its long-term storage. However, the process of reconsolidating the memory takes time to complete, and during this limited time window, the original memory may be modified either by the presentation of new information or with pharmacological agents. Such findings have prompted rising interest in using disruption during reconsolidation as a clinical intervention for anxiety, posttraumatic stress, and substance use disorders...
March 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28346120/investigation-of-consensually-nonmonogamous-relationships
#8
Terri Conley, Jessica Matsick, Amy Catherine Moors, Ali Ziegler
We proposed that the premise that monogamy is the exemplary form of romantic partnership underlies much theory and research on relationship quality, and we addressed how this bias has prompted methodological issues that make it difficult to effectively address the quality of nonmonogamous relationships. Because the idea that consensually nonmonogamous (CNM) relationships are functional (i.e., satisfying and of high quality) is controversial, we included a basic study to assess, in a variety of ways, the quality of these relationships...
March 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28346081/pneumocystis-jiroveci-pneumonia-pjp-in-non-hiv-immunocompromised-individuals
#9
Kathleen Schoovaerts, Luc Dirix, Annemie Rutten, Jef Van Schaeren, Bruno Van Herendael, Sofie Van Grieken, Luc Heytens
OBJECTIVES: PJP is a major cause of morbidity and mortality in immunocompromised individuals. Diagnosing PJP is often difficult because respiratory signs might be minimal or absent and the sensitivity of a chest X-ray (CXR) is low. We studied the clinical risk factors in order to increase awareness and facilitate the diagnosis. METHODS: We studied a prospective case series over a one year period (from 1 January 2015 to 1 January 2016) and did a retrospective analysis (from 2013 to 2016) of all PJP positive bronchoalveolar lavage (BAL) analysis...
March 27, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28346007/lipid-emulsion-improves-survival-in-animal-models-of-local-anesthetic-toxicity-a-meta-analysis
#10
Michael R Fettiplace, Daniel J McCabe
INTRODUCTION: The Lipid Emulsion Therapy workgroup, organized by the American Academy of Clinical Toxicology, recently conducted a systematic review, which subjectively evaluated lipid emulsion as a treatment for local anesthetic toxicity. We re-extracted data and conducted a meta-analysis of survival in animal models. METHODS: We extracted survival data from 26 publications and conducted a random-effect meta-analysis based on odds ratio weighted by inverse variance...
February 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28345959/ventilatory-inefficiency-and-exertional-dyspnea-in-early-chronic-obstructive-pulmonary-disease
#11
J Alberto Neder, Danilo C Berton, Paulo de Tarso Müller, Amany F Elbehairy, Alcides Rocha, Paolo Palange, Denis E O'Donnell
Exertional dyspnea is present across the spectrum of chronic obstructive pulmonary disease (COPD) severity. However, without realizing it themselves, patients may decrease daily physical activity to avoid distressing respiratory sensations. Dyspnea also may be associated with deconditioning. Cardiopulmonary exercise testing can uncover exertional dyspnea and its physiological determinants in patients with preserved or only mildly-reduced FEV1. Dyspnea in mild COPD can largely be explained by increased "wasted" ventilation in the physiological dead space which heightens the drive to breathe and worsens the inspiratory mechanical constraints...
March 27, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28345491/a-comparison-of-toxicities-in-acute-myeloid-leukemia-patients-with-and-without-renal-impairment-treated-with-decitabine
#12
Lauren B Levine, Julianna Vf Roddy, Miryoung Kim, Junan Li, Gary Phillips, Alison R Walker
Purpose There are limited data regarding the clinical use of decitabine for the treatment of acute myeloid leukemia in patients with a serum creatinine of 2 mg/dL or greater. Methods We retrospectively evaluated 111 patients with acute myeloid leukemia who had been treated with decitabine and compared the development of toxicities during cycle 1 in those with normal renal function (creatinine clearance greater than or equal to 60 mL/min) to those with renal dysfunction (creatinine clearance less than 60 mL/min)...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28345475/understanding-bladder-management-on-a-palliative-care-unit-a-grounded-theory-study
#13
Iris Gutmanis, Melissa Hay, Joshua Shadd, Janette Byrne, Sarah McCallum, Kristen Bishop, Patricia Whitfield, Cathy Faulds
BACKGROUND: Research regarding factors associated with nursing-initiated changes to bladder management at end-of-life is sparse. OBJECTIVES: To explore the process of Palliative Care Unit (PCU) nurses' approach to bladder management changes. METHODS: Nursing staff from one PCU in London, Canada were interviewed regarding bladder management care practices. A constructivist grounded theory was generated. RESULTS: Four interconnected themes emerged: humanity (compassionate support of patients); journey (making the most of a finite timeline); health condition (illness, functional decline); and context (orders, policies, supplies)...
March 16, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28345398/challenges-in-the-surgical-management-of-ectopic-pregnancy-in-a-low-resource-setting-mpilo-central-hospital-bulawayo-zimbabwe
#14
Solwayo Ngwenya
Background Ectopic pregnancy contributes to maternal morbidity and mortality, especially in low-resourced countries with limited facilities for early diagnosis and treatment. It is a very challenging condition to diagnose. Patients may collapse and die while undergoing investigation. Aims To assess surgical treatment given to patients presenting at Mpilo Central Hospital, the challenges that are faced and the outcomes; and also to document how women survive this dangerous condition in a setting challenged by low resources...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28345375/the-chemo-prophylactic-efficacy-of-an-ethanol-moringa-oleifera-leaf-extract-against-hepatocellular-carcinoma-in-rats
#15
Kadry M Sadek, Tarek K Abouzed, Reham Abouelkhair, Sherif Nasr
CONTEXT: Hepatocellular carcinoma (HCC) is among the most well-known threatening tumours around the world, and the outlook remains bleak. Moringa oleifera Lam. (Moringaceae) exhibits antitumor, antioxidant and hepatoprotective properties. OBJECTIVES: To assess the chemo-prophylactic proficiency and other likely activities of Moringa oleifera leaf ethanol extract (MOLEE) against diethyl nitrosamine (DEN)-induced HCC. MATERIALS AND METHODS: Wistar rats were gastrogavaged with MOLEE (500 mg/kg) for one week and then gastrogavaged with MOLEE and DEN (10 mg/kg) for the following 16 weeks...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28345347/a-systematic-evaluation-of-the-n-f-bond-strength-of-electrophilic-n-f-reagents-hints-for-atomic-fluorine-donating-ability
#16
Jin-Dong Yang, Ya Wang, Xiao-Song Xue, Jin-Pei Cheng
The recent uncovering of the radical reactivity of a few traditionally electrophilic N-F reagents has sparked a renaissance of radical fluorination. A knowledge of the N-F bond dissociation enthalpies (BDE) of electrophilic N-F reagents is essential for the understanding of their reactivities. However, a thorough literature survey revealed that such information is extremely sparse. This prompted us to carry out the first systematic computation on the N-F BDEs of electrophilic N-F reagents. The calculated N-F BDE scale of 88 electrophilic N-F reagents ranges from 49...
March 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28345325/potential-role-of-e4-protein-in-human-papillomavirus-screening-a-review
#17
REVIEW
Aidy Irman Yajid, Mohd Azali Zakariah, Anani Aila Mat Zin, Nor Hayati Othman
In 2006, cervical cancer was reported as the second most common cancer in women of Malaysia. This type of cancer has been shown to correlate with persistent high risk human papillomavirus (HPV) infection. Although HPV is well known to induce cervical cancer, knowledge of pathways that link the latent stage of the viral replication cycle to precancerous and cancerous stages remains incomplete. However, it is interesting to note that the virus can be isolated from tissues ranging from normal to low-grade squamous intraepithelial lesions as well as high-grade intraepithelial lesions (HSILs), thus prompting scientists to develop HPV detection methods for screening...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345284/role-of-fine-needle-aspiration-cytology-in-the-diagnosis-of-a-rare-case-of-a-poorly-differentiated-synovial-sarcoma-with-rhabdoid-features-including-treatment-implications
#18
Bharat Rekhi, Omshree Shetty, Mukta Ramadwar, Venkatesh Rangarajan, Jyoti Bajpai
Synovial sarcoma is a high-grade, soft tissue sarcoma that is relatively chemosensitive. Its exact diagnosis is crucial, including differentiation from its closest diagnostic mimic, ie, Ewing sarcoma, in view of different treatment options, including chemotherapy regimens, for both these tumors. A 15-year-old girl presented with a recurrent soft tissue mass in her right popliteal region, which was diagnosed as Ewing sarcoma, based on positive immunoexpression of MIC2/CD99, Fli1 and negative expression of LCA and desmin...
March 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28344950/impalement-head-injury-with-a-spear
#19
B I Akhiwu, A S Adoga, O P Binitie, C C Ani, M Iweagwu, O Adetutu, T Ureme, D D George, P D Didamson, E Oseni-Momodu, B T Ugwu
Impalement injuries to the craniofacial region are uncommon due to the fact that the face is a smaller target in relation to the rest of the body. We report a case of a 26-year old man who was attacked on the face with a spear. He was promptly evaluated and resuscitated; the blade of the spear was successfully extracted under general anaesthesia. He was discharged home after 2 weeks hospitalization; he has been followed up for three months with good outcome.
April 2016: Journal of the West African College of Surgeons
https://www.readbyqxmd.com/read/28344900/temporal-patterns-and-geographic-heterogeneity-of-zika-virus-zikv-outbreaks-in-french-polynesia-and-central-america
#20
Ying-Hen Hsieh
BACKGROUND: Zika virus (ZIKV) transmission has been reported in 67 countries/territories in the Oceania region and the Americas since 2015, prompting the World Health Organization (WHO) to declare ZIKV as a Public Health Emergency of International Concern in February 2016, due to its strong association with medical complications such as microcephaly and Guillain-Barré Syndrome (GBS). However, a substantial gap in knowledge still exists regarding differing temporal pattern and potential of transmission of ZIKV in different regions of the world...
2017: PeerJ
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