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https://www.readbyqxmd.com/read/29793180/insulin-is-a-potential-antioxidant-for-diabetes-associated-cognitive-decline-via-regulating-nrf2-dependent-antioxidant-enzymes
#1
Ying Song, Wei Ding, Yun Bei, Yan Xiao, Hai-Da Tong, Li-Bo Wang, Li-Yao Ai
PURPOSE: To investigate the neuroprotective effects of insulin on diabetic encephalopathy and its mechanism. EXPERIMENTAL AND APPROACH: The diabetic model was established by injection of streptozotocin. Behavior examinations were conducted by the Morris water maze. Histopathological alterations were detected by HE staining. ROS, CAT levels and SOD activity were measured using a microplate reader. In vitro, the viability of wild type and knock-down PC12 cells was detected by MTT assay, the morphology of cells was monitored under a microscope...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793174/effect-of-ca-2-ion-concentration-on-adsorption-of-poly-carboxylate-ether-based-pce-superplasticizer-on-mica
#2
Bo Wu, Byong-Wa Chun, Le Gu, Tonya L Kuhl
HYPOTHESIS: Poly(carboxylate ether)-based (PCE) superplasticizers consist of a carboxylic acid backbone and grafted poly(ethylene glycol) (PEG) side chains. Ca2+ ion bridging mechanism is commonly purported to control PCE's adsorption on negatively charged cement particle surfaces in cement suspension, thus PCE was expected to adsorb on negatively charged surfaces in synthetic pore solutions via Ca2+ /COO- interactions. EXPERIMENTS: Adsorption behaviors of a commercial PCE on negatively charged mica were studied in aqueous electrolyte solutions by a surface forces apparatus...
May 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793164/childhood-socioeconomic-status-and-longitudinal-patterns-of-alcohol-problems-variation-across-etiological-pathways-in-genetic-risk
#3
Peter B Barr, Judy Silberg, Danielle M Dick, Hermine H Maes
Childhood socioeconomic status (SES) is an important aspect of early life environment associated with later life health/health behaviors, including alcohol misuse. However, alcohol misuse is modestly heritable and involves differing etiological pathways. Externalizing disorders show significant genetic overlap with substance use, suggesting an impulsivity pathway to alcohol misuse. Alcohol misuse also overlaps with internalizing disorders, suggesting alcohol is used to cope. These differing pathways could lead to different patterns over time and/or differential susceptibility to environmental conditions, such as childhood SES...
May 14, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29793157/energy-dissipation-in-quasi-linear-viscoelastic-tissues-cells-and-extracellular-matrix
#4
Behzad Babaei, A J Velasquez-Mao, Kenneth M Pryse, William B McConnaughey, Elliot L Elson, Guy M Genin
Characterizing how a tissue's constituents give rise to its viscoelasticity is important for uncovering how hidden timescales underlie multiscale biomechanics. These constituents are viscoelastic in nature, and their mechanics must typically be assessed from the uniaxial behavior of a tissue. Confounding the challenge is that tissue viscoelasticity is typically associated with nonlinear elastic responses. Here, we experimentally assessed how fibroblasts and extracellular matrix (ECM) within engineered tissue constructs give rise to the nonlinear viscoelastic responses of a tissue...
May 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29793156/mechanical-properties-of-the-human-scalp-in-tension
#5
Lisa Falland-Cheung, Mario Scholze, Pamela F Lozano, Benjamin Ondruschka, Darryl C Tong, Paul A Brunton, J Neil Waddell, Niels Hammer
Mechanical properties of the human scalp have not been investigated to a great extent with limited information available. The purpose of this study was to provide new baseline material data for human scalp tissue of various ages, which can be applied to experimental and constitutive models, such as in the area of impact biomechanics. This study used specimens from the left and right temporal, fronto-parietal and occipital regions of the human scalp. It investigated the tensile behavior of scalp tissue using tissues harvested from unfixed, fresh cadavers...
May 17, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29793154/juvenile-treatment-with-mglur2-3-agonist-prevents-schizophrenia-like-phenotypes-in-adult-by-acting-through-gsk3%C3%AE
#6
Bo Xing, Genie Han, Min-Juan Wang, Melissa A Snyder, Wen-Jun Gao
Prodromal memory deficits represent an important marker for the development of schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex (PFC). The mGluR2/3 agonist LY379268 (LY37) attenuates excitatory N-methyl-D-aspartate receptor (NMDAR)-induced neurotoxicity, a central pathological characteristic of glutamatergic hypofunction. We therefore hypothesized that early treatment with LY37 would rescue cognitive deficits and confer benefits for SZ-like behaviors in adults. To test this, we assessed whether early intervention with LY37 would improve learning outcomes in the Morris Water Maze for rats prenatally exposed to methylazoxymethanol acetate (MAM), a neurodevelopmental SZ model...
May 14, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29793111/desire-understanding-in-2-year-old-children-an-eye-tracking-study
#7
Amrisha Vaish, Robert Hepach, Tobias Grossmann
'Much research has investigated children's understanding of others' mental states in terms of beliefs, but far less is known about their understanding of others' desires. To fill this gap, we used an eye-tracking paradigm to test 2-year-old children's desire understanding by measuring their anticipatory looking behavior as well as changes in their internal arousal (i.e., changes in pupil dilation). Children showed increased pupil dilation when an adult reached for an object she had previously emoted negatively towards (the object incongruent with her desire)...
May 21, 2018: Infant Behavior & Development
https://www.readbyqxmd.com/read/29793102/joint-attention-in-down-syndrome-a-meta-analysis
#8
REVIEW
Laura J Hahn, Susan J Loveall, Madison T Savoy, Allie M Neumann, Toshikazu Ikuta
BACKGROUND: Some studies have indicated that joint attention may be a relative strength in Down syndrome (DS), but other studies have not. AIM: To conduct a meta-analysis of joint attention in DS to more conclusively determine if this is a relative strength or weakness when compared to children with typical development (TD), developmental disabilities (DD), and autism spectrum disorder (ASD). METHODS AND PROCEDURES: Journal articles published before September 13, 2016, were identified by using the search terms "Down syndrome" and "joint attention" or "coordinating attention"...
May 21, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29793084/subthreshold-depression-among-diabetes-patients-in-beijing-cross-sectional-associations-among-sociodemographic-clinical-and-behavior-factors
#9
Dandan Wang, Lintao Shi, Leling Li, Xiaohui Guo, Yufeng Li, Yuan Xu, Shinan Yin, Qiaozhen Wu, Yu Yang, Xiaoming Zhuang, Yingli Gai, Quanmin Li, Yanjun Liu
BACKGROUND: This study explores the prevalence of subthreshold depression (SubD) and its association with factors in type 2 diabetes mellitus (T2DM) patients. METHODS: This cross-sectional study involved 808 outpatients with T2DM from ten hospitals in Beijing between September 2015 and January 2016. All participants completed the Patient Health Questionnaire 9-item (PHQ-9) to evaluate depressive status, with scores between 5 and 14 considered SubD. Conditional logistic regression was conducted to investigate the variables associated with SubD in T2DM patients...
May 18, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29793078/comparison-of-performance-based-assessment-and-real-world-skill-in-people-with-serious-mental-illness-ecological-validity-of-the-test-of-grocery-shopping-skills
#10
Laura A Faith, Melisa V Rempfer
Valid functional measures are essential for clinical and research efforts that address recovery and community functioning in people with serious mental illness. Although there is a great deal of interest in functional assessment, there is limited research supporting how well current evaluation methods provide a true assessment of real world functioning or naturalistic behavior. To address this gap in the literature, the present study examined the performance of individuals with serious mental illness (i.e., diagnosis of schizophrenia-spectrum, bipolar disorder, or other depression/anxiety diagnoses and accompanying functional disability) on the Test of Grocery Shopping Skills (TOGSS), a performance-based naturalistic task...
May 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29793072/leveraging-semantic-labels-for-multi-level-abstraction-in-medical-process-mining-and-trace-comparison
#11
Giorgio Leonardi, Manuel Striani, Silvana Quaglini, Anna Cavallini, Stefania Montani
Many medical information systems record data about the executed process instances in the form of an event log. In this paper, we present a framework, able to convert actions in the event log into higher level concepts, at different levels of abstraction, on the basis of domain knowledge. Abstracted traces are then provided as an input to trace comparison and semantic process discovery. Our abstraction mechanism is able to manage non trivial situations, such as interleaved actions or delays between two actions that abstract to the same concept...
May 21, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29793042/aminergic-neuromodulation-of-associative-visual-learning-in-harnessed-honey-bees
#12
Nino Mancini, Martin Giurfa, Jean-Christophe Sandoz, Aurore Avarguès-Weber
The honey bee Apis mellifera is a major insect model for studying visual cognition. Free-flying honey bees learn to associate different visual cues with a sucrose reward and may deploy sophisticated cognitive strategies to this end. Yet, the neural bases of these capacities cannot be studied in flying insects. Conversely, immobilized bees are accessible to neurobiological investigation but training them to respond appetitively to visual stimuli paired with sucrose reward is difficult. Here we succeeded in coupling visual conditioning in harnessed bees with pharmacological analyses on the role of octopamine (OA), dopamine (DA) and serotonin (5-HT) in visual learning...
May 21, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29793014/calf-muscle-oxygen-saturation-during-six-minute-walk-test-and-its-relationship-with-walking-impairment-in-symptomatic-peripheral-artery-disease
#13
Aluísio Andrade-Lima, Gabriel G Cucato, Wagner J R Domingues, Antônio H Germano-Soares, Bruno R Cavalcante, Marilia A Correia, Glauco F Saes, Nelson Wolosker, Andrew W Gardner, Antônio E Zerati, Raphael M Ritti-Dias
OBJECTIVE: Impaired microcirculation is associated with poor walking capacity in symptomatic peripheral artery disease (PAD) patients during treadmill test, however, this test does not simulate the efforts of daily walking of these patients. Thus, the aim of the study was to describe the microcirculation responses during six-minute walk test (6MWT) and to analyze the relationship between microcirculation indicators and walking impairment in symptomatic PAD patients. METHODS: Thirty-four patients were included (mean age = 67...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792987/the-rheological-and-textural-characterization-of-soluplus-%C3%A2-vitamin-e-composites
#14
Ahmad Salawi, Sami Nazzal
Soluplus® is a graft amphiphilic copolymer that is frequently used as an excipient in solid dosage forms as a dissolution and a solubility enhancer. We discovered that Soluplus® can be dissolved in vitamin E. The result is a tacky and highly adhesive material. Our research objective was to evaluate the rheological, adhesive, and textural properties of the Soluplus® /Vitamin E composites. In this study, Soluplus® was dissolved under heat in vitamin E at increasing concentrations from 0 to 40% (by weight)...
May 21, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29792967/validated-reverse-phase-hplc-diode-array-method-for-the-quantification-of-intact-bevacizumab-infliximab-and-trastuzumab-for-long-term-stability-study
#15
Antonio Martínez-Ortega, Agustín Herrera, Antonio Salmerón-García, José Cabeza, Luis Cuadros-Rodríguez, Natalia Navas
The aim of the present study was to develop suitable and reliable method for quantification three of the most worldwide used therapeutic monoclonal antibodies (mAbs) -bevazizumab (BVZ), infliximab (INF) and trastuzumab (TTZ)- to be used in long-term stability studies. Reverse phase (RP) was selected by its greater sensibility and reproducibility comparing with other chromatographic modes. Then a high performance liquid chromatography with diode array detection (RP)HPLC/DAD method was checked. Since the three mAbs represent the active ingredient in the medicines in which they are formulated, the selected method was validated for each one in accordance with the International Conference on Harmonization (ICH) guidelines for pharmaceuticals for human use...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792958/impact-of-cooking-conditions-on-the-properties-of-rice-combined-temperature-and-cooking-time
#16
Meng He, Chen Qiu, Zhanghua Liao, Zhongquan Sui, Harold Corke
Changes in the properties of cooked rice under various cooking conditions were investigated. Waxy, low-, and high-amylose rice were subjected to treatment with different cooking temperatures (50, 70, 90 °C) for different cooking times (15, 30, 45 min). The results showed that cooking greatly increased the swelling behavior of waxy rice but decreased the swelling behavior and amylose leaching of low- and high-amylose rice. As the cooking temperature increased, rapidly digestible starch increased significantly for all rice products, whereas slowly digestible starch and resistant starch had a certain degree of reduction...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792941/in-situ-analysis-of-grain-rotation-and-lattice-strain-within-a-magnesium-polycrystal-based-on-synchrotron-polychromatic-x-ray-diffraction-technique-i-prior-to-twin
#17
Li Li, Yuanzhi Wu, Jie Wu
Hexagonal-close-packed structure aggregates exhibit complicated deformation behaviors, involving different slips and twinning. Synchrotron polychromatic X-ray microdiffraction (micro-XRD) was utilized to study in situ an extruded Mg-3Al-1Zn strip subjected to uniaxial tension. The evolution of grain rotation and lattice strain was analyzed under the load levels from 12 to 73 MPa. The micro-XRD data was used to map an area of 396 × 200 μm within the region of interest. The experimental set-up and X-ray diffraction microscopy in two dimensions allow the morphology, orientation and strain of the target grain to be determined at the submicron size...
May 17, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29792902/session-4-discussion-the-built-environment
#18
Blake Jones, Jayne Fulkerson, Michael Widner, Steve Douglas
The following is a transcript from "The Built Environment" session during the Ingestive Behavior Research Conference at Purdue University.
May 21, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29792892/beef-quality-labels-a-combination-of-sensory-acceptance-test-stated-willingness-to-pay-and-choice-based-conjoint-analysis
#19
Stephan G H Meyerding, Maria Gentz, Brianne Altmann, Lisa Meier-Dinkel
Consumer perspectives of beef quality are complex, leading to a market that is increasingly differentiating. Thus, ongoing monitoring and assessment of changes in consumer perspectives is essential to identify changing market conditions. Often only credence and search characteristics are evaluated in consumer studies; therefore the object of the present study is to examine consumer preferences and perceptions towards beef steaks, also including experience characteristics, using a mixed methods approach. For this reason, 55 consumers participated in an experiment in Germany, including a sensory acceptance test, stated willingness to pay, and choice-based conjoint analysis (CBCA)...
May 21, 2018: Appetite
https://www.readbyqxmd.com/read/29792891/pcl-eug-scaffolds-with-tunable-stiffness-can-regulate-macrophage-secretion-behavior
#20
REVIEW
Y Z B Xue, Yiming Niu, B Tang, C M Wang
Osteoarthritis (OA) is a prevalent joint disorder worldwide. Recent studies suggested that macrophages play an important role in the progression of OA. However, the detailed pathology related to macrophages is still ambiguous, especially those related to mechanotransduction. In this study, PCL/EUG composite scaffolds were first fabricated by electrospinning. The stiffness of as-fabricated scaffolds was controlled by adjusting the PCL-versus-EUG ratio. The mechanical properties, structural characterics and chemical composition of the scaffolds were investigated using various materials characterization techniques...
May 21, 2018: Progress in Biophysics and Molecular Biology
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