keyword
MENU ▼
Read by QxMD icon Read
search

Response-independent

keyword
https://www.readbyqxmd.com/read/28210781/adolescent-cocaine-exposure-enhances-goal-tracking-behavior-and-impairs-hippocampal-cell-genesis-selectively-in-adult-bred-low-responder-rats
#1
M Julia García-Fuster, Aram Parsegian, Stanley J Watson, Huda Akil, Shelly B Flagel
RATIONALE: Environmental challenges during adolescence, such as drug exposure, can cause enduring behavioral and molecular changes that contribute to life-long maladaptive behaviors, including addiction. Selectively bred high-responder (bHR) and low-responder (bLR) rats represent a unique model for assessing the long-term impact of adolescent environmental manipulations, as they inherently differ on a number of addiction-related traits. bHR rats are considered "addiction-prone," whereas bLR rats are "addiction-resilient," at least under baseline conditions...
February 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28195391/rig-i-is-a-key-antiviral-interferon-stimulated-gene-against-hepatitis-e-virus-dispensable-of-interferon-production
#2
Lei Xu, Wenshi Wang, Yunlong Li, Xinying Zhou, Yuebang Yin, Yijin Wang, Robert A de Man, Luc J W van der Laan, Fen Huang, Nassim Kamar, Maikel P Peppelenbosch, Qiuwei Pan
: Interferons (IFNs) are broad antiviral cytokines that exert their function by inducing the transcription of hundreds of interferon-stimulated genes (ISGs). However, little is known about the antiviral potential of these cellular effectors on hepatitis E virus (HEV) infection, the leading cause of acute hepatitis globally. In this study, we profiled the antiviral potential of a panel of important human ISGs on HEV replication in cell culture models by overexpression of individual ISG...
February 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28193847/dna-damage-response-independent-role-for-mdc1-in-maintaining-genomic-stability
#3
Zhiguo Li, Chen Shao, Yifan Kong, Colin Carlock, Nihal Ahmad, Xiaoqi Liu
MDC1 is a central player in checkpoint activation and subsequent DNA repair following DNA damage. Although MDC1 has been extensively studied, much of its known functions to date pertains to the DNA damage response (DDR) pathway. Herein, we report a novel function of phosphorylated MDC1, independent of ATM and DNA damage, which is required for proper mitotic progression and maintenance of genomic stability. We demonstrate that MDC1 is an in vivo target of Plk1 and that the phosphorylated MDC1 is dynamically localized to nuclear envelopes, centrosomes, kinetochores and the midbodies...
February 13, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28193764/shoot-removal-induces-chloroplast-development-in-roots-via-cytokinin-signaling
#4
Koichi Kobayashi, Ai Ohnishi, Daichi Sasaki, Sho Fujii, Akira Iwase, Keiko Sugimoto, Tatsuru Masuda, Hajime Wada
Development of plant chloroplasts is regulated by various developmental, environmental, and hormonal cues. In Arabidopsis thaliana, chloroplast development is repressed in roots via auxin signaling. However, roots develop chloroplasts when they are detached from the shoot. In contrast to auxin, cytokinin positively affects chloroplast development in roots, but the role and signaling pathway of cytokinin in the root greening response remain unclear. To understand the regulatory pathways of chloroplast development in the plant stress response, we examined the mechanisms underlying the conditional greening of detached roots...
February 13, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28177480/circulating-tumour-cells-and-pathological-complete-response-independent-prognostic-factors-in-inflammatory-breast-cancer-in-a-pooled-analysis-of-two-multicentre-phase-ii-trials-beverly-1-and-2-of-neoadjuvant-chemotherapy-combined-with-bevacizumab
#5
J-Y Pierga, F-C Bidard, A Autret, T Petit, F Andre, F Dalenc, C Levy, J-M Ferrero, G Romieu, J Bonneterre, F Lerebours, T Bachelot, P Kerbrat, M Campone, J-C Eymard, M-A Mouret-Reynier, J Gligorov, A-C Hardy-Bessard, A Lortholary, P Soulie, J-M Boher, C Proudhon, E Charafe-Jaufret, J Lemonnier, F Bertucci, P Viens
No abstract text is available yet for this article.
January 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28122715/primary-cilia-regulate-the-osmotic-stress-response-of-renal-epithelial-cells-through-trpm3
#6
Brian J Siroky, Nancy K Kleene, Steven J Kleene, Charles D Varnell, Raven G Comer, Jialiu Liu, Lu Lu, Nolan W Pachciarz, John J Bissler, Bradley P Dixon
Primary cilia sense environmental conditions including osmolality, but whether cilia participate in osmotic response in renal epithelial cells is not known. Transient receptor potential (TRP) channels TRPV4 and TRPM3 are osmoresponsive. TRPV4 localizes to cilia in certain cell types, while renal subcellular localization of TRPM3 is not known. We hypothesized that primary cilia are required for maximal activation of the osmotic response of renal epithelial cells, and that ciliary TRPM3 and TRPV4 mediate that response...
January 25, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28117243/patient-perceptions-of-integrated-care-and-their-relationship-to-utilization-of-emergency-inpatient-and-outpatient-services
#7
Ashley-Kay Fryer, Mark W Friedberg, Ryan W Thompson, Sara J Singer
BACKGROUND: Patients with multiple chronic conditions have garnered particular attention from policymakers and health service researchers because these patients utilize more services and contribute disproportionally to rising health care expenses. The growing prevalence of patients with multiple chronic conditions has increased the importance of achieving better health care integration for this patient population. Patients may be well positioned to assess integration of their care, but the relationship between patients' perceptions of care integration and use of health services has not been studied...
January 21, 2017: Healthcare
https://www.readbyqxmd.com/read/28094276/b7-h3-participates-in-the-development-of-asthma-by-augmentation-of-the-inflammatory-response-independent-of-tlr2-pathway
#8
Wenjing Gu, Xinxing Zhang, Yongdong Yan, Yuqing Wang, Li Huang, Meijuan Wang, Xuejun Shao, Zhengrong Chen, Wei Ji
B7-H3, a new member of the B7 superfamily, acts as both a T cell costimulator and coinhibitor. Recent studies identified B7-H3 plays a critical role in the development of asthma. But the definitive mechanism is not clear. In this study, we further report that B7-H3 participates in the development of OVA-induced asthma in a murine model. And study its mechanism through the vitro and vivo experiment. Exogenous administration of B7-H3 strongly amplified the inflammatory response and augmented proinflammatory cytokines in vitro and vivo...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081195/assessment-of-volumetric-versus-manual-measurement-in-disseminated-testicular-cancer-no-difference-in-assessment-between-non-radiologists-and-genitourinary-radiologist
#9
Çiğdem Öztürk, Ton Velleman, Alphons H H Bongaerts, L M Bergman, Robert J van Ginkel, Jourik A Gietema, Harald J Hoekstra
BACKGROUND: The aim of this study was to assess the feasibility and reproducibility of semi-automatic volumetric measurement of retroperitoneal lymph node metastases in testicular cancer (TC) patients treated with chemotherapy versus the standardized manual measurements based on RECIST criteria. METHODS: 21 TC patients with retroperitoneal lymph node metastases of testicular cancer were studied with a CT scan of chest and abdomen before and after cisplatin based chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28061843/sun-protection-to-improve-vaccine-effectiveness-in-children-in-a-high-ambient-ultraviolet-radiation-and-rural-environment-an-intervention-study
#10
Caradee Y Wright, Patricia N Albers, Angela Mathee, Zamantimande Kunene, Catherine D'Este, Ashwin Swaminathan, Robyn M Lucas
BACKGROUND: Vaccination is a mainstay of preventive healthcare, reducing the incidence of serious childhood infections. Ecological studies have demonstrated an inverse association between markers of high ambient ultraviolet (UV) radiation exposure (e.g., sunny season, low latitude of residence) and reduction in the vaccination-associated immune response. Higher sun exposure on the day prior to and spanning the day of vaccination has been associated with a reduced antigen-specific immune response independent of skin pigmentation...
January 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28018863/immunization-with-the-mipa-skp-or-etec_2479-antigens-confers-protection-against-enterotoxigenic-e-coli-strains-expressing-different-colonization-factors-in-a-mouse-pulmonary-challenge-model
#11
Michael P Hays, Amit Kumar, Francisco J Martinez-Becerra, Philip R Hardwidge
Achieving cross-protective efficacy against multiple bacterial strains or serotypes is an important goal of vaccine design. Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrheal disease in underdeveloped nations. We have been interested in identifying and characterizing ETEC antigens that generate protective immune responses independent of ETEC colonization factor (CF) expression. Our previous studies used proteomics to identify the ETEC MipA, Skp, and ETEC_2479 proteins as effective in protecting mice from homologous challenge with ETEC H10407 using a pulmonary inoculation model...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28013188/a-capture-method-based-on-the-vc1-domain-reveals-new-binding-properties-of-the-human-receptor-for-advanced-glycation-end-products-rage
#12
Genny Degani, Alessandra A Altomare, Mara Colzani, Caterina Martino, Angelica Mazzolari, Guenter Fritz, Giulio Vistoli, Laura Popolo, Giancarlo Aldini
The Advanced Glycation and Lipoxidation End products (AGEs and ALEs) are a heterogeneous class of compounds derived from the non-enzymatic glycation or protein adduction by lipoxidation break-down products. The receptor for AGEs (RAGE) is involved in the progression of chronic diseases based on persistent inflammatory state and oxidative stress. RAGE is a pattern recognition receptor (PRR) and the inhibition of the interaction with its ligands or of the ligand accumulation have a potential therapeutic effect...
December 18, 2016: Redox Biology
https://www.readbyqxmd.com/read/27966553/microbiota-metabolite-short-chain-fatty-acid-acetate-promotes-intestinal-iga-response-to-microbiota-which-is-mediated-by-gpr43
#13
W Wu, M Sun, F Chen, A T Cao, H Liu, Y Zhao, X Huang, Y Xiao, S Yao, Q Zhao, Z Liu, Y Cong
Intestinal IgA, which is regulated by gut microbiota, has a crucial role in maintenance of intestinal homeostasis and in protecting the intestines from inflammation. However, the means by which microbiota promotes intestinal IgA responses remain unclear. Emerging evidence suggests that the host can sense gut bacterial metabolites in addition to pathogen-associated molecular patterns and that recognition of these small molecules influences host immune response in the intestines and beyond. We reported here that microbiota metabolite short-chain fatty acid acetate promoted intestinal IgA responses, which was mediated by "metabolite-sensing" GPR43...
December 14, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27956580/visual-discomfort-from-flash-afterimages-of-riloid-patterns
#14
Louise O'Hare
Op-art-based stimuli have been shown to be uncomfortable, possibly due to a combination of fixational eye movements (microsaccades) and excessive cortical responses. Efforts have been made to measure illusory phenomena arising from these stimuli in the absence of microsaccades, but there has been no attempt thus far to decouple the effects of the cortical response from the effect of fixational eye movements. This study uses flash afterimages to stabilise the image on the retina and thus reduce the systematic effect of eye movements, in order to investigate the role of the brain in discomfort from op-art-based stimuli...
December 11, 2016: Perception
https://www.readbyqxmd.com/read/27932205/cold-induced-sympathetic-tone-modifies-the-impact-of-endothelium-dependent-vasodilation-in-the-finger-pulp
#15
Tone Kristin Bergersen, Maria Skytioti, Maja Elstad
OBJECTIVE: In thermoneutral and cold subjects, the sympathetic nervous system regulates skin blood flow by adjusting frequency of the tonic vasoconstrictor impulses. However, the way these thermoregulatory impulses influence the vascular endothelium is not well known. We studied how the sympathetic nervous system influences endothelium-dependent vasodilation (EDV) caused by shear stress in skin containing arteriovenous anastomoses (AVAs) and arterioles in healthy subjects. METHODS: Thirteen healthy subjects were exposed to thermoneutral (29°C) and cold (22°C) ambient temperatures on separate days...
November 30, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27931844/dendritic-cells-in-hematological-malignancies
#16
REVIEW
Domenico Galati, Gaetano Corazzelli, Rosaria De Filippi, Antonio Pinto
Dendritic cells (DCs) are bone-marrow-derived immune cells accounted for a crucial role in initiating and modulating the adaptive immune response and supporting the innate immune response independently from T cells. While functioning as the most effective antigen-presenting cells within the immune system, DCs can otherwise induce tolerance in central and peripheral lymphoid organs acting therefore as suppressors rather than stimulators of the immune response. Within mechanisms regulating antitumor immunity, DCs can capture antigens from viable or damaged tumor cells and present the processed peptides to T-cells to prompt the generation and maintenance of an effective tumor-specific T-cell response...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27906453/spleen-tyrosine-kinase-inhibition-blocks-airway-constriction-and-protects-from-th2-induced-airway-inflammation-and-remodeling
#17
C Tabeling, J Herbert, A C Hocke, D J Lamb, S L Wollin, K J Erb, E Boiarina, H Movassagh, J Scheffel, J M Doehn, S Hippenstiel, M Maurer, A S Gounni, W M Kuebler, N Suttorp, M Witzenrath
BACKGROUND: Spleen tyrosine kinase (Syk) is an intracellular nonreceptor tyrosine kinase, which has been implicated as central immune modulator promoting allergic airway inflammation. Syk inhibition has been proposed as a new therapeutic approach in asthma. However, the direct effects of Syk inhibition on airway constriction independent of allergen sensitization remain elusive. METHODS: Spectral confocal microscopy of human and murine lung tissue was performed to localize Syk expression...
December 1, 2016: Allergy
https://www.readbyqxmd.com/read/27905069/pavlovian-reward-learning-underlies-value-driven-attentional-capture
#18
Berno Bucker, Jan Theeuwes
Recent evidence shows that distractors that signal high compared to low reward availability elicit stronger attentional capture, even when this is detrimental for task-performance. This suggests that simply correlating stimuli with reward administration, rather than their instrumental relationship with obtaining reward, produces value-driven attentional capture. However, in previous studies, reward delivery was never response independent, as only correct responses were rewarded, nor was it completely task-irrelevant, as the distractor signaled the magnitude of reward that could be earned on that trial...
November 30, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27870107/stimulus-reinforcer-relations-established-during-training-determine-resistance-to-extinction-and-relapse-via-reinstatement
#19
John Y H Bai, C K Jonas Chan, Douglas Elliffe, Christopher A Podlesnik
The baseline rate of a reinforced target response decreases with the availability of response-independent sources of alternative reinforcement; however, resistance to disruption and relapse increases. Because many behavioral treatments for problem behavior include response-dependent reinforcement of alternative behavior, the present study assessed whether response-dependent alternative reinforcement also decreases baseline response rates but increases resistance to extinction and relapse. We reinforced target responding at equal rates across two components of a multiple schedule with pigeons...
November 2016: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/27819680/syndecan-1-increases-b-lymphoid-cell-extravasation-in-response-to-hiv-1-tat-via-%C3%AE-v%C3%AE-3-pp60src-pp125fak-pathway
#20
C Urbinati, E Grillo, P Chiodelli, C Tobia, F Caccuri, S Fiorentini, G David, M Rusnati
Syndecan-1 is a heparan sulfate proteoglycan (HSPG) commonly upregulated in AIDS-related B lymphoid malignancies. Tat is the main HIV-1 transactivating factor that has a major role in the pathogenesis of AIDS-related lymphomas (ARL) by engaging heparan sulfate proteoglycans (HSPGs), chemokine receptors and integrins at the lymphoid cell (LC) surface. Here B-lymphoid Namalwa cell clones that do not express or overexpress syndecan-1 (EV-Ncs and SYN-Ncs, respectively) were compared for their responsiveness with Tat: in the absence of syndecan-1, Tat induces a limited EV-Nc migration via C-X-C motif chemokine receptor 4 (CXCR4), G-proteins and Rac...
November 7, 2016: Oncogene
keyword
keyword
112565
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"