keyword
https://read.qxmd.com/read/38501238/survival-predictors-of-radioiodine-refractory-differentiated-thyroid-cancer-treated-with-lenvatinib-in-the-real-life
#1
JOURNAL ARTICLE
Vincenzo Marotta, Domenico Rocco, Anna Crocco, Maria Grazia Deiana, Ruggero Martinelli, Francesca Di Gennaro, Mariafelicia Valeriani, Luca Valvano, Alessia Caleo, Luciano Pezzullo, Antongiulio Faggiano, Mario Vitale, Salvatore Monti
CONTEXT: Lenvatinib is approved for the treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). The definition of predictive factors of survival is incomplete. OBJECTIVE: To identify pre- and post- treatment survival predictors in a real-life cohort of RR-DTC treated with lenvatinib. DESIGN: Multicenter, retrospective, cohort study. SETTING: Three Italian thyroid cancer referral centers. PARTECIPANTS: 55 RR-DTC treated with lenvatinib...
March 19, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38426846/differences-in-the-phenotypic-expression-of-posttraumatic-stress-disorder-symptoms-in-us-military-veterans-with-and-without-clinical-insomnia
#2
JOURNAL ARTICLE
Jason C DeViva, Elissa McCarthy, Ian Fischer, Robert H Pietrzak
STUDY OBJECTIVES: The goal of this study was to examine the phenotypic expression of posttraumatic stress disorder (PTSD) symptoms in veterans with probable PTSD and clinical insomnia relative to those with probable PTSD alone. METHODS: Data were analyzed from the 2019-2020 National Health and Resilience in Veterans Study, which surveyed a nationally representative sample of 4,069 US military veterans. RESULTS: A total of 3.9% of the full sample screened positive for probable PTSD and clinical insomnia and 3...
March 1, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/38418825/prediction-of-plasma-ctdna-fraction-and-prognostic-implications-of-liquid-biopsy-in-advanced-prostate-cancer
#3
JOURNAL ARTICLE
Nicolette M Fonseca, Corinne Maurice-Dror, Cameron Herberts, Wilson Tu, William Fan, Andrew J Murtha, Catarina Kollmannsberger, Edmond M Kwan, Karan Parekh, Elena Schönlau, Cecily Q Bernales, Gráinne Donnellan, Sarah W S Ng, Takayuki Sumiyoshi, Joanna Vergidis, Krista Noonan, Daygen L Finch, Muhammad Zulfiqar, Stacy Miller, Sunil Parimi, Jean-Michel Lavoie, Edward Hardy, Maryam Soleimani, Lucia Nappi, Bernhard J Eigl, Christian Kollmannsberger, Sinja Taavitsainen, Matti Nykter, Sofie H Tolmeijer, Emmy Boerrigter, Niven Mehra, Nielka P van Erp, Bram De Laere, Johan Lindberg, Henrik Grönberg, Daniel J Khalaf, Matti Annala, Kim N Chi, Alexander W Wyatt
No consensus strategies exist for prognosticating metastatic castration-resistant prostate cancer (mCRPC). Circulating tumor DNA fraction (ctDNA%) is increasingly reported by commercial and laboratory tests but its utility for risk stratification is unclear. Here, we intersect ctDNA%, treatment outcomes, and clinical characteristics across 738 plasma samples from 491 male mCRPC patients from two randomized multicentre phase II trials and a prospective province-wide blood biobanking program. ctDNA% correlates with serum and radiographic metrics of disease burden and is highest in patients with liver metastases...
February 28, 2024: Nature Communications
https://read.qxmd.com/read/38407136/multiple-sources-of-unconscious-information-processing-affect-a-single-response-independent-unconscious-priming-effects
#4
JOURNAL ARTICLE
Dingding Wang, Jiuhong Yan, Jun Li, Jerwen Jou, Jun Jiang, Jiang Qiu, Shen Tu
At present there is little knowledge on whether and how multiple pieces of unconscious information can simultaneously affect a single conscious response. In the present study, we manipulated the congruency relation between a masked prime arrow and the target arrow, as well as that between masked flankers and the target arrow. The results demonstrated that the masked prime and flankers produced independent unconscious priming effects on the response to the target. In the process of studying the above phenomenon, two secondary findings were made...
February 26, 2024: Journal of General Psychology
https://read.qxmd.com/read/38400344/a-combined-magnetoelectric-sensor-array-and-mri-based-human-head-model-for-biomagnetic-fem-simulation-and-sensor-crosstalk-analysis
#5
JOURNAL ARTICLE
Mesut-Ömür Özden, Giuseppe Barbieri, Martina Gerken
Magnetoelectric (ME) magnetic field sensors are novel sensing devices of great interest in the field of biomagnetic measurements. We investigate the influence of magnetic crosstalk and the linearity of the response of ME sensors in different array and excitation configurations. To achieve this aim, we introduce a combined multiscale 3D finite-element method (FEM) model consisting of an array of 15 ME sensors and an MRI-based human head model with three approximated compartments of biological tissues for skin, skull, and white matter...
February 11, 2024: Sensors
https://read.qxmd.com/read/38397397/proteomic-and-metabolomic-analysis-of-the-quercus-ilex-phytophthora-cinnamomi-pathosystem-reveals-a-population-specific-response-independent-of-co-occurrence-of-drought
#6
JOURNAL ARTICLE
Tamara Hernández-Lao, Marta Tienda-Parrilla, Mónica Labella-Ortega, Victor M Guerrero-Sánchez, María-Dolores Rey, Jesús V Jorrín-Novo, María Ángeles Castillejo-Sánchez
Holm oak ( Quercus ilex ) is considered to be one of the major structural elements of Mediterranean forests and the agrosilvopastoral Spanish "dehesa", making it an outstanding example of ecological and socioeconomic sustainability in forest ecosystems. The exotic Phytophthora cinnamomi is one of the most aggressive pathogens of woody species and, together with drought, is considered to be one of the main drivers of holm oak decline. The effect of and response to P. cinnamomi inoculation were studied in the offspring of mother trees from two Andalusian populations, Cordoba and Huelva...
January 29, 2024: Biomolecules
https://read.qxmd.com/read/38302791/binding-of-response-independent-task-rules
#7
JOURNAL ARTICLE
Moritz Schiltenwolf, David Dignath, Eliot Hazeltine
Binding theories claim that features of an episode are bound to each other and can be retrieved once these features are re-encountered. Binding effects have been shown in task-switching studies with a strong focus on bindings of observable features such as responses. In this study, we aimed to investigate whether task rules, translating stimulus information into motor output can be bound and subsequently retrieved even if they act independently from specific response codes. To address this question, we utilized a task-switching paradigm with varying visual context features...
February 1, 2024: Psychonomic Bulletin & Review
https://read.qxmd.com/read/38278364/plant-stanol-consumption-increases-anti-covid-19-antibody-responses-independent-of-changes-in-serum-cholesterol-concentrations-a-randomized-controlled-trial
#8
JOURNAL ARTICLE
Lieve van Brakel, Ronald P Mensink, Dieter Lütjohann, Jogchum Plat
BACKGROUND: People with overweight/obesity generally have impaired immune responses, resulting among others in increased risk of severe complaints and hospitalization after infections with severe acute respiratory syndrome coronavirus 2 (COVID-19), as well as decreased antibody production after vaccinations. Plant stanol ester previously increased the combined IgM/IgG antibody titers toward a hepatitis A vaccination in patients with allergic asthma, but the underlying mechanism is unknown...
January 24, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38215455/the-ability-of-artificial-intelligence-chatbots-chatgpt-and-google-bard-to-accurately-convey-pre-operative-information-for-patients-undergoing-ophthalmological-surgeries
#9
JOURNAL ARTICLE
Nikhil S Patil, Ryan Huang, Andrew Mihalache, Eli Kisilevsky, Jason Kwok, Marko M Popovic, Georges Nassrallah, Clara Chan, Ashwin Mallipatna, Peter J Kertes, Rajeev H Muni
INTRODUCTION: To determine whether the two popular artificial intelligence (AI) chatbots, ChatGPT and Bard, provide high-quality information concerning procedure description, risks, benefits, and alternatives of various ophthalmological surgeries. METHODS: ChatGPT and Bard were prompted with questions pertaining to the description, potential risks, benefits, alternatives, and implications of not proceeding with various surgeries in different subspecialties of ophthalmology...
January 9, 2024: Retina
https://read.qxmd.com/read/38213267/cardiorespiratory-fitness-is-linked-with-heart-rate-variability-during-stress-in-at-risk-adults
#10
JOURNAL ARTICLE
Anniina Salmio, Antti-Pekka E Rissanen, Jari L O Kurkela, Mirva Rottensteiner, Santtu Seipäjärvi, Joona Juurakko, Urho M Kujala, Jari A Laukkanen, Jan Wikgren
BACKGROUND: Physiological mechanisms explaining why cardiorespiratory fitness (CRF) predicts cardiovascular morbidity and mortality are incompletely understood. We examined if CRF modifies vagally mediated heart rate variability (HRV) during acute physical or psychosocial stress or night-time sleep in adults with cardiovascular risk factors. METHODS: Seventy-eight adults (age 56 years [IQR 50-60], 74% female, body mass index 28 kg/m2 [IQR 25-31]) with frequent cardiovascular risk factors participated in this cross-sectional study...
January 11, 2024: Journal of Sports Medicine and Physical Fitness
https://read.qxmd.com/read/38176866/use-of-oxygen-ozone-therapy-to-improve-the-effectiveness-of-antibiotic-treatment-on-infected-arthroplasty-protocol-for-a-superiority-open-label-multicentre-randomised-parallel-trial
#11
JOURNAL ARTICLE
Fidelia Cascini, Marianno Franzini, Arnaldo Andreoli, Alfonso Manzotti, Chiara Cadeddu, Gianluigi Quaranta, Andrea Gentili, Walter Ricciardi
INTRODUCTION: Surgical site infections still remain a major public health challenge and have become an increasing universal risk, especially for the implantation of orthopaedic devices.Unfortunately, the discovery and increasingly widespread use (especially the misuse) of antibiotics have led to the rapid appearance of antibiotic-resistant strains today; more and more infections are caused by microorganisms that fail to respond to conventional treatments.Oxygen-ozone therapy has been extensively used and studied for decades across various potential medical applications and has provided consistent effects with minimal side effects...
January 4, 2024: BMJ Open
https://read.qxmd.com/read/38169561/nrf2-promotes-radiation-resistance-by-cooperating-with-topbp1-to-activate-the-atr-chk1-signaling-pathway
#12
JOURNAL ARTICLE
Xiaohui Sun, Mingxin Dong, Jiale Li, Yuxiao Sun, Yu Gao, Yan Wang, Liqing Du, Yang Liu, Kaihua Ji, Ningning He, Jinhan Wang, Manman Zhang, Huijuan Song, Chang Xu, Qiang Liu
Background: Radiation resistance is the main limitation of the application of radiotherapy. Ionizing radiation (IR) kills cancer cells mainly by causing DNA damage, particularly double-strand breaks (DSBs). Radioresistant cancer cells have developed the robust capability of DNA damage repair to survive IR. Nuclear factor erythroid 2-related factor 2 (NRF2) has been correlated with radiation resistance. We previously reported a novel function of NRF2 as an ATR activator in response to DSBs. However, little is known about the mechanism that how NRF2 regulates DNA damage repair and radiation resistance...
2024: Theranostics
https://read.qxmd.com/read/38158140/genome-wide-transcriptomic-and-biochemical-profiling-of-major-depressive-disorder-unravelling-association-with-susceptibility-severity-and-antidepressant-response
#13
JOURNAL ARTICLE
Priyanka Singh, Ankit Srivastava, Lini Philip, Simranpreet Kaur Ahuja, Shivangi, Chitra Rawat, Rintu Kutum, Jyoti Yadav, Mamta Sood, Rakesh Kumar Chadda, Debasis Dash, Divya Vohora, Ritushree Kukreti
Identifying biomarkers for diagnosing Major Depressive Disorder (MDD), assessing its severity, and guiding treatment is crucial. We conducted whole genome transcriptomic study in North Indian population, and analyzed biochemical parameters. Our longitudinal study investigated gene-expression profiles from 72 drug-free MDD patients and 50 healthy controls(HCs) at baseline and 24 patients after 12-weeks of treatment. Gene expression analyses identified differentially expressed genes(DEGs) associated with MDD susceptibility, symptom severity and treatment response, independently validated by qPCR...
December 27, 2023: Genomics
https://read.qxmd.com/read/38142455/structure-of-the-wyl-domain-containing-transcription-activator-drid-in-complex-with-ssdna-effector-and-dna-target-site
#14
JOURNAL ARTICLE
Maria A Schumacher, Emily Cannistraci, Raul Salinas, Devin Lloyd, Ella Messner, Kevin Gozzi
Transcription regulators play central roles in orchestrating responses to changing environmental conditions. Recently the Caulobacter crescentus transcription activator DriD, which belongs to the newly defined WYL-domain family, was shown to regulate DNA damage responses independent of the canonical SOS pathway. However, the molecular mechanisms by which DriD and other WYL-regulators sense environmental signals and recognize DNA are not well understood. We showed DriD DNA-binding is triggered by its interaction with ssDNA, which is produced during DNA damage...
December 24, 2023: Nucleic Acids Research
https://read.qxmd.com/read/38107064/is-chatgpt-accurate-and-reliable-in-answering-questions-regarding-head-and-neck-cancer
#15
JOURNAL ARTICLE
Oğuz Kuşcu, A Erim Pamuk, Nilda Sütay Süslü, Sefik Hosal
BACKGROUND AND OBJECTIVE: Chat Generative Pre-trained Transformer (ChatGPT) is an artificial intelligence (AI)-based language processing model using deep learning to create human-like text dialogue. It has been a popular source of information covering vast number of topics including medicine. Patient education in head and neck cancer (HNC) is crucial to enhance the understanding of patients about their medical condition, diagnosis, and treatment options. Therefore, this study aims to examine the accuracy and reliability of ChatGPT in answering questions regarding HNC...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38067164/alteration-of-immunoregulatory-patterns-and-survival-advantage-of-key-cell-types-in-food-allergic-children
#16
JOURNAL ARTICLE
Kamal Ivory, Rossella Angotti, Mario Messina, Denise Bonente, Ferdinando Paternostro, Massimo Gulisano, Claudio Nicoletti
All allergic responses to food indicate the failure of immunological tolerance, but it is unclear why cow's milk and egg (CME) allergies resolve more readily than reactivity to peanuts (PN). We sought to identify differences between PN and CME allergies through constitutive immune status and responses to cognate and non-cognate food antigens. Children with confirmed allergy to CME ( n = 6) and PN ( n = 18) and non-allergic (NA) ( n = 8) controls were studied. Constitutive secretion of cytokines was tested in plasma and unstimulated mononuclear cell (PBMNC) cultures...
November 30, 2023: Cells
https://read.qxmd.com/read/38042893/cytosolic-actin-isoforms-form-networks-with-different-rheological-properties-that-indicate-specific-biological-function
#17
JOURNAL ARTICLE
Peter Nietmann, Kevin Kaub, Andrejus Suchenko, Susanne Stenz, Claas Warnecke, Mohan K Balasubramanian, Andreas Janshoff
The implications of the existence of different actins expressed in epithelial cells for network mechanics and dynamics is investigated by microrheology and confocal imaging. γ-actin predominately found in the apical cortex forms stiffer networks compared to β-actin, which is preferentially organized in stress fibers. We attribute this to selective interactions with Mg2+ -ions interconnecting the filaments' N-termini. Bundling propensity of the isoforms is different in the presence of Mg2+ -ions, while crosslinkers such as α-actinin, fascin, and heavy meromyosin alter the mechanical response independent of the isoform...
December 2, 2023: Nature Communications
https://read.qxmd.com/read/38011044/retraction-hypothalamic-inhibition-of-acetyl-coa-carboxylase-stimulates-hepatic-counter-regulatory-response-independent-of-ampk-activation-in-rats
#18
(no author information available yet)
No abstract text is available yet for this article.
2023: PloS One
https://read.qxmd.com/read/37982677/artificial-intelligence-versus-expert-plastic-surgeon-comparative-study-shows-chatgpt-wins-rhinoplasty-consultations-should-we-be-worried
#19
JOURNAL ARTICLE
K Kay Durairaj, Omer Baker, Dario Bertossi, Steven Dayan, Kian Karimi, Roy Kim, Sam Most, Enrico Robotti, Frank Rosengaus
Introduction: Large language models, such as ChatGPT, hold tremendous promise to bridge gaps in patient education and enhance the decision-making resources available online for patients seeking nasal surgery. Objective: To compare the performance of ChatGPT in answering preoperative and postoperative patient questions related to septorhinoplasty. Methods: Two sets of responses were collected for the questions: one from an expert rhinoplasty surgeon with over two decades of experience, and the other from ChatGPT-3...
November 20, 2023: Facial plastic surgery & aesthetic medicine
https://read.qxmd.com/read/37975429/visualizing-the-dynamics-of-plant-energy-organelles
#20
JOURNAL ARTICLE
Amanda M Koenig, Bo Liu, Jianping Hu
Plant organelles predominantly rely on the actin cytoskeleton and the myosin motors for long-distance trafficking, while using microtubules and the kinesin motors mostly for short-range movement. The distribution and motility of organelles in the plant cell are fundamentally important to robust plant growth and defense. Chloroplasts, mitochondria, and peroxisomes are essential organelles in plants that function independently and coordinately during energy metabolism and other key metabolic processes. In response to developmental and environmental stimuli, these energy organelles modulate their metabolism, morphology, abundance, distribution and motility in the cell to meet the need of the plant...
November 17, 2023: Biochemical Society Transactions
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