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https://www.readbyqxmd.com/read/29444550/non-invasive-assessment-of-kidney-allograft-fibrosis-with-shear-wave-elastography-a-radiological-pathological-correlation-analysis
#1
Maggie Km Ma, Helen Kw Law, Kin Sun Tse, Kwok Wah Chan, Gary Cw Chan, Desmond Yh Yap, Maggie My Mok, Lorraine Py Kwan, Sydney Cw Tang, Bo Ying Choy, Tak Mao Chan
OBJECTIVES: To evaluate the use of shear wave elastography in assessment of kidney allograft tubulointerstitial fibrosis. METHODS: Shear wave elastography assessment was carried out by two independent operators in kidney transplant recipients who underwent allograft biopsy for clinical indications (i.e. rising creatinine >15% or proteinuria >1 g/day). Allograft biopsies were interpreted by the same pathologist according to the 2013 Banff Classification. RESULTS: A total of 40 elastography scans were carried out (median creatinine 172...
February 14, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29444541/functional-regions-of-the-medial-patellofemoral-ligament
#2
Gang Ji, Yifei Sun, Jiangfeng Lu, Yingzhen Niu, Fei Wang
The purpose of this study was to explore the anatomy and discuss functional regions of the medial patellofemoral ligament (MPFL). Twelve fresh-frozen knees specimens were dissected. All medial surfaces of knees were intact and did not have indication of injury. General feature of the MPFL were observed. All anatomical landmarks were carefully identified and marked. The length of the two functional regions were conducted and recorded. All data were obtained, described, and analyzed in the form of mean ± standard deviation...
February 14, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29444538/-effects-of-judo-specific-resistance-training-on-kinetic-and-electromyographic-parameters-of-pulling-exercises-in-judo-athletes
#3
Norman Helm, Olaf Prieske, Thomas Muehlbauer, Tom Krüger, Urs Granacher
BACKGROUND: In judo, rapid force production during pulling movements is an important component of athletic performance, which is why this capacity needs to be specifically exercised in judo. This study aimed at examining the effects of a judo-specific resistance training program using a judo ergometer system (PTJ) versus a traditional resistance training regime using a partner (PTP) on kinetics and muscle activity of judo-specific pulling exercises. METHOD: Twenty-four male judo athletes (age: 22 ± 4 years, training experience: 15 ± 3 years) were randomly assigned to two groups...
February 14, 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29444537/a-novel-patient-recruitment-strategy-patient-selection-directly-from-the-community-through-linkage-to-clinical-data
#4
Lindsay P Zimmerman, Satyender Goel, Shazia Sathar, Charon E Gladfelter, Alejandra Onate, Lindsey L Kane, Shelly Sital, Jasmin Phua, Paris Davis, Helen Margellos-Anast, David O Meltzer, Tamar S Polonsky, Raj C Shah, William E Trick, Faraz S Ahmad, Abel N Kho
OBJECTIVE:  This article presents and describes our methods in developing a novel strategy for recruitment of underrepresented, community-based participants, for pragmatic research studies leveraging routinely collected electronic health record (EHR) data. METHODS:  We designed a new approach for recruiting eligible patients from the community, while also leveraging affiliated health systems to extract clinical data for community participants. The strategy involves methods for data collection, linkage, and tracking...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29444515/comprehensive-mirna-analysis-of-human-umbilical-cord-derived-mesenchymal-stromal-cells-and-extracellular-vesicles
#5
Xiang-Yu Zou, Yongjiang Yu, Sihao Lin, Liang Zhong, Jie Sun, Guangyuan Zhang, Yingjian Zhu
BACKGROUND/AIMS: Mesenchymal stromal cells (MSCs) participate in the tissue-specific repair of many different organs, especially the kidney. Their effects are primarily mediated by the paracrine release of factors including extracellular vesicles (EVs), which are composed of micro-vesicles and exosomes. The corresponding microRNAs (miRNAs) of EVs are considered important for their biological functions. METHODS: MSCs were cultured from the human umbilical cord, and EVs were isolated from the medium...
February 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29444490/systematic-evaluation-of-matrix-effects-in-supercritical-fluid-chromatography-versus-liquid-chromatography-coupled-to-mass-spectrometry-for-biological-samples
#6
Vincent Desfontaine, Francesca Capetti, Raul Nicoli, Tiia Kuuranne, Jean-Luc Veuthey, Davy Guillarme
Matrix effects (ME) is acknowledged as being one of the major drawbacks of quantitative bioanalytical methods, involving the use of liquid chromatography coupled to mass spectrometry (LC-MS). In the present study, the incidence of ME in SFC-MS/MS and LC-MS/MS in the positive mode electrospray ionization (ESI+) was systematically compared for the analysis of urine and plasma samples using two representative sets of 40 doping agents and 38 pharmaceutical compounds, respectively. Three different SFC stationary phase chemistries were employed, to highlight the importance of the column in terms of selectivity...
February 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29444486/brook-trout-distributional-response-to-unconventional-oil-and-gas-development-landscape-context-matters
#7
Eric R Merriam, J Todd Petty, Kelly O Maloney, John A Young, Stephen P Faulkner, E Terrence Slonecker, Lesley E Milheim, Atesmachew Hailegiorgis, Jonathan Niles
We conducted a large-scale assessment of unconventional oil and gas (UOG) development effects on brook trout (Salvelinus fontinalis) distribution. We compiled 2231 brook trout collection records from the Upper Susquehanna River Watershed, USA. We used boosted regression tree (BRT) analysis to predict occurrence probability at the 1:24,000 stream-segment scale as a function of natural and anthropogenic landscape and climatic attributes. We then evaluated the importance of landscape context (i.e., pre-existing natural habitat quality and anthropogenic degradation) in modulating the effects of UOG on brook trout distribution under UOG development scenarios...
February 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29444477/the-microbiome-in-chronic-kidney-disease-patients-undergoing-hemodialysis-and-peritoneal-dialysis
#8
REVIEW
Liliana Simões-Silva, Ricardo Araujo, Manuel Pestana, Isabel Soares-Silva, Benedita Sampaio-Maia
Chronic kidney disease (CKD) is associated with an imbalanced human microbiome due not only to CKD-associated factors such as uremia, increased inflammation and immunosuppression, but also to pharmacological therapies and dietary restrictions. End-stage renal disease patients require renal replacement therapies commonly in the form of hemodialysis (HD) or peritoneal dialysis (PD). HD implies the existence of a vascular access, such as an arteriovenous fistula/graft or a venous catheter, whereas PD implies a long-term peritoneal catheter and the constant inflow of peritoneal dialysate...
February 11, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29444473/adhesive-properties-of-calcium-pectinate-gels-prepared-from-callus-cultures-pectins
#9
Elena A Günter, Anatoliy K Melekhin, Vladislav S Belozerov, Boris A Ananchenko, Ekaterina A Martinson, Sergey G Litvinets
The aim of this research is to investigate the influence of the surface morphology of the calcium pectinate gel (CaPG) beads as well as the physicochemical characteristics of pectins and the CaPG beads on the adhesive properties of gels against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Bacillus subtilis. The adhesion of the bacteria depends on the type of pectin and the surface morphology of the beads. The faster adhesion on CaPG beads appeared to be related to a lower degree of methyl esterification (DE), a higher molecular weight (Mw) and specific viscosity of the pectin and a higher gel strength...
February 11, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29444467/olfactory-function-in-systemic-lupus-erythematosus-and-systemic-sclerosis-a-longitudinal-study-and-review-of-the-literature
#10
REVIEW
Mariana Freschi Bombini, Fernando Augusto Peres, Aline Tamires Lapa, Nailú Angélica Sinicato, Beatriz Ricato Quental, Ágatha de Souza Melo Pincelli, Tiago Nardi Amaral, Caroline Cristina Gomes, Ana Paula Del Rio, João Francisco Marques-Neto, Lilian T L Costallat, Paula Teixeira Fernandes, Fernando Cendes, Leticia Rittner, Simone Appenzeller
BACKGROUND/PURPOSE: To evaluate olfactory function in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and healthy controls over a 2-year period, and to determine the association of olfactory dysfunction with age, disease activity, disease damage, treatment, anxiety and depression symptoms and limbic structures volumes. METHODS: Consecutive SLE and SSc patients were enrolled in this study. Clinical, laboratory disease activity and damage were assessed according to diseases specific guidelines...
February 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29444466/interference-and-problem-size-effect-in-multiplication-fact-solving-individual-differences-in-brain-activations-and-arithmetic-performance
#11
Alice De Visscher, Stephan E Vogel, Gernot Reishofer, Eva Hassler, Karl Koschutnig, Bert De Smedt, Roland H Grabner
In the development of math ability, a large variability of performance in solving simple arithmetic problems is observed and has not found a compelling explanation yet. One robust effect in simple multiplication facts is the problem size effect, indicating better performance for small problems compared to large ones. Recently, behavioral studies brought to light another effect in multiplication facts, the interference effect. That is, high interfering problems (receiving more proactive interference from previously learned problems) are more difficult to retrieve than low interfering problems (in terms of physical feature overlap, namely the digits, De Visscher and Noël, 2014)...
February 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29444454/assessing-the-blocking-of-occasion-setting
#12
Felipe Alfaro, Jorge Mallea, Mario A Laborda, Aracelli Cañete, Gonzalo Miguez
An occasion setter (OS) is a stimulus or context with the capacity to disambiguate an ambiguous conditioned stimulus (CS). Previous research has shown that OSs share some features with regular Pavlovian CSs. Amongst them, research has shown that OSs are subject to blocking; that is, a new OS exerts reduced behavioral control after training in compound with a previously established OS. Of additional interest, in Pavlovian blocking, it has been reported that a blocked CS comes to elicit conditioned responding after the extinction of the blocking CS...
February 11, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29444447/difference-between-observed-and-predicted-glycated-hemoglobin-at-baseline-and-treatment-response-to-vildagliptin-based-dual-oral-therapy-in-patients-with-type-2-diabetes
#13
Jun-Sing Wang, Yi-Jen Hung, Yung-Chuan Lu, Cheng-Lin Tsai, Wei-Shiung Yang, Ting-I Lee, Ya-Chun Hsiao, Wayne Huey-Herng Sheu
AIM: We aimed to investigate the association of difference between observed and predicted glycated hemoglobin (dopHbA1c) and HbA1c reduction after vildagliptin-based oral therapy in patients with type 2 diabetes (T2D). METHODS: This was a prospective observational study. Adults ≥20 years old with T2D and HbA1c ≧7% treated with oral anti-diabetic drugs (OADs) were eligible if their OADs were shifted to vildagliptin-based dual oral therapy. Fasting plasma glucose (FPG) and HbA1c were recorded at baseline, week 12, and week 24...
February 11, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29444444/vertical-disconjugacy-during-reading-in-dyslexic-and-non-dyslexic-children
#14
Nathalie Goulème, Cynthia Lions, Christophe-Loïc Gérard, Hugo Peyre, Hung Thai-Van, Maria Pia Bucci
PURPOSE: The objective of this study was to explore vertical binocular coordination in dyslexic and non-dyslexic children during saccades and post-saccadic fixation period while reading a text. METHODS: Binocular eye movements were recorded by an infrared system (Mobile T2 ® , SuriCog) in thirty-six dyslexic children from 7.3 to 13.6 years of age (mean age: 10.6 ± 0.3 years) who were asked to silently read a four-line text during binocular viewing. Data were compared to those of thirty-six age-matched non-dyslexic children...
February 11, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29444417/a-study-on-the-regenerative-effect-of-platelets-rich-plasma-on-experimentally-induced-hepatic-damage-in-albino-rats
#15
Heba Mamdoh Shoeib, Walaa Arafa Keshk, Abdallah Mahmoud Foda, Saad El-Deen Abd Elfatah Abo El Noeman
Hepatic fibrosis is a worldwide health problem with significant morbidity and mortality. Currently, there is no effective therapy for hepatic fibrosis. So that the present study was aimed to evaluate the possible regenerative effect of Platelet-rich plasma (PRP) against thioacetamide (TAA) induced hepatic damage. Eighty albino rats were included; 40 were used for PRP preparation and 40 were randomly divided into four groups. Group I (control group); group II (PRP control); group III (TAA- intoxicated in a dose of 200 mg ∕ kg body weight/twice weekly for 7 weeks, intra-peritoneal and group IV (TAA-intoxicated+ PRP treated)...
February 14, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29444416/structural-changes-in-the-cell-envelope-of-yarrowia-lipolytica-yeast-under-stress-conditions
#16
Anna Yurievna Arinbasarova, Andrey Valerievich Machulin, Elena Nikolaevna Biryukova, Vladimir Vladislavovich Sorokin, Alexander Grigorievich Medentsev, Nataliya Egorovna Suzina
The ultrastructural changes in the cell envelope of the yeast Yarrowia lipolytica as stress response were examined using electron microscopy technique. The formation of new cellular surface structures including membrane vesicles, pore channels and wall surface globules were shown for the first time under conditions of oxidative (endogenous and exogenous) or thermal stress. This demonstrates once again that under stress conditions the microorganisms reveal properties unknown for them before. Particularly noteworthy is the silicon accumulation, which was revealed at the surface globules with X-ray microanalysis of the elemental composition of cells' thin sections...
February 14, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29444414/no-individual-or-combined-effects-of-caffeine-and-beetroot-juice-supplementation-during-submaximal-or-maximal-running
#17
Johanna Oskarsson, Kerry McGawley
BACKGROUND: Dietary supplements such as caffeine and beetroot juice are used by athletes in an attempt to optimize performance and therefore gain an advantage in competition. AIM: To investigate the individual and combined effects of caffeine and beetroot-juice supplementation during submaximal and maximal treadmill running. METHODS: Seven males (VO<sub>2max</sub>: 59.0 ± 2.9 mL/kg/min) and two females (VO<sub>2max</sub>: 53...
February 14, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29444376/secukinumab-demonstrates-high-sustained-efficacy-and-a-favorable-safety-profile-in-patients-with-moderate-to-severe-psoriasis-through-5-years-of-treatment-sculpture-extension-study
#18
R Bissonnette, T Luger, D Thaçi, D Toth, A Lacombe, S Xia, R Mazur, M Patekar, P Charef, M Milutinovic, C Leonardi, U Mrowietz
BACKGROUND: Secukinumab, a fully human monoclonal antibody that selectively neutralizes IL-17A, has been shown to have significant efficacy and a favorable safety profile in the treatment of moderate to severe psoriasis and psoriatic arthritis. OBJECTIVE: To assess the efficacy and safety of secukinumab through 5 years of treatment in moderate to severe psoriasis. METHODS: In the core SCULPTURE study, Psoriasis Area and Severity Index (PASI) 75 responders at Week 12 continued receiving subcutaneous secukinumab until Year 1...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29444369/rotaviral-non-structural-protein-4-triggers-dynamin-related-protein-1-dependent-mitochondrial-fragmentation-during-infection
#19
Arpita Mukherjee, Upayan Patra, Rahul Bhowmick, Mamta Chawla-Sarkar
Dynamic equilibrium between mitochondrial fission and mitochondrial fusion serves as an important quality control system within cells ensuring cellular vitality and homeostasis. Viruses often target mitochondrial dynamics as a part of their obligatory cellular reprogramming. The present study was undertaken to assess the status and regulation of mitochondrial dynamics during rotavirus (RV) infection. Distinct fragmentation of mitochondrial syncytia was observed during late hours of RV (SA11, Wa, A5-13) infection...
February 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29444368/establishment-of-an-in-vivo-simulating%C3%A2-co-culture-assay-platform-for-genotoxicity-of-multi-walled-carbon-nanotubes
#20
Emi Fukai, Haruna Sato, Masatoshi Watanabe, Dai Nakae, Yukari Totsuka
Engineered nanomaterials (ENMs) are now used in a wide variety of fields, and thus their safety should urgently be assessed and secured. It has been suggested that inflammatory responses via the phagocytosis of ENMs by macrophages is a key mechanism for their genotoxicity. The present study was conducted to establish a mechanism-based assay to evaluate the genotoxicity of ENMs under conditions simulating an in vivo situation, featuring a co-culture system of murine lung resident cells (GDL1) and immune cells (RAW264...
February 14, 2018: Cancer Science
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