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https://www.readbyqxmd.com/read/28351117/clinical-characteristics-of-patients-with-untreated-achalasia
#1
Han Ho Jeon, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jeffrey L Conklin
Background/Aims: Patients with untreated achalasia frequently complain of heartburn and regurgitation. The diagnosis of achalasia might be delayed because these symptoms are misinterpreted as gastroesophageal reflux. We aim to evaluate the clinical presentation, radiologic, and manometric findings in patient untreated achalasia. Methods: The records of patients diagnosed with primary achalasia between July 2004 and January 2012 at Gangnam Severance Hospital, Seoul, Korea were evaluated...
March 28, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28351091/plasma-betatrophin-levels-of-subjects-classified-with-normal-impaired-and-diabetic-glucose-tolerance-and-subjects-with-impaired-fasting-glucose
#2
Sibel Ozyazgan, Burak Onal, Eda Merve Kurtulus, Hafize Uzun, Gokhan Akkan, Dildar Konukoglu
This study was aimed to investigate whether betatrophin shows glucose intolerance or not. To access the plasma betatrophin levels after basal and glucose load, groups were classified as normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetic glucose tolerance (DGT) according to WHO 2012 criteria. An oral glucose tolerance test was performed on age-matched subjects (n=220) with a body mass index (BMI)<27 kg/m(2). Subjects were categorized as normoglycemic (n=55), IFG (n=50), IGT (n=60), and DM (n=55) according to the WHO criteria...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351088/premature-progesterone-rise-positively-correlates-with-clinical-pregnancy-rate-in-in-vitro-fertilization-ivf-and-intracytoplasmic-sperm-injection-icsi-patients-with-good-ovarian-response
#3
Na Cui, Jie Zhang, Yueming Xu, Lei Jiang, Aimin Yang, Guimin Hao
Infertility affects millions of couples worldwide resulting in distress and depression. In the past several decades, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been developed with high efficiency and success rate. The possible effects of gonadotropin administration on follicular metabolism have been discussed but the outcomes remain controversial. The aim of this study was to identify whether serum progesterone on the day of human chorionic gonadotropin (hCG) administration and the ratio of serum progesterone and the number of oocyte retrieved (P/O) had a predictive role for the outcomes of IVF/ICSI...
March 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351085/thyroid-function-and-metabolic-syndrome-a-population-based-thyroid-study
#4
Ladan Mehran, Atieh Amouzegar, Parnian Kheirkhah Rahimabad, Maryam Tohidi, Zhale Tahmasebinejad, Fereidoun Azizi
The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged≥20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5 422 subjects to be investigated...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28351071/neurologic-deficits-have-a-negative-impact-on-patient-related-outcomes-in-primary-presentation-adult-symptomatic-lumbar-scoliosis-surgical-treatment-at-one-year-follow-up
#5
Daniel G Kang, Christine Baldus, Steven D Glassman, Christopher I Shaffrey, Jon D Lurie, Keith H Bridwell
STUDY DESIGN: A retrospective analysis of prospective, multicenter National Institute of Health clinical trial. OBJECTIVE: The aim of this study was to assess the rate of neurologic complications and impact of new neurologic deficits on 1-year postoperative patient-reported outcomes (PROs). SUMMARY OF BACKGROUND DATA: There are limited studies evaluating the impact of new neurologic deficits on PROs following surgery for primary presentation adult lumbar scoliosis...
April 1, 2017: Spine
https://www.readbyqxmd.com/read/28351068/what-attitudes-and-values-are-incorporated-into-self-as-part-of-professional-identity-construction-when-becoming-a-surgeon
#6
Alexandra Cope, Jeff Bezemer, Stella Mavroveli, Roger Kneebone
PURPOSE: To make explicit the attitudes and values of a community of surgeons, with the aim of understanding professional identity construction within a specific group of residents. METHOD: Using a grounded theory method, the authors collected data from 16 postgraduate surgeons through interviews. They complemented these initial interview data with ethnographic observations and additional descriptive interviews to explore the attitudes and values learned by surgeons during residency training (2010-2013)...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351063/from-communication-skills-to-skillful-communication-a-longitudinal-integrated-curriculum-for-critical-care-medicine-fellows
#7
Amanda L Roze des Ordons, Christopher J Doig, Philippe Couillard, Jason Lord
PROBLEM: Communication with patients and families in critical care medicine (CCM) can be complex and challenging. A longitudinal curricular model integrating multiple techniques within classroom and clinical milieus may facilitate skillful communication across diverse settings. APPROACH: In 2014-2015, the authors developed and implemented a curriculum for CCM fellows at the Cumming School of Medicine, University of Calgary, to promote the longitudinal development of skillful communication...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351050/miscellaneous
#8
Catherine Creuzot-Garcher
This chapter provides the reader with practical information to be applied to the various remaining causes of macular edema. Some clinical cases of macular edema linked to ocular diseases like postradiotherapy for ocular melanomas remained of poor functional prognosis due to the primary disease. On the contrary, macular edema occurring after retinal detachment or after diverse systemic or local treatment use is often temporary. Macular edema associated with epiretinal membranes or vitreomacular traction is the main cause of poor functional recovery...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351022/reference-values-and-factors-associated-with-musculoskeletal-symptoms-in-healthy-adolescents-and-adults
#9
Jennifer N Baldwin, Marnee J McKay, Niamh Moloney, Claire E Hiller, Elizabeth J Nightingale, Joshua Burns
BACKGROUND: Insufficient attention has been given to individuals who report musculoskeletal symptoms yet experience minimal disability. OBJECTIVES: To examine musculoskeletal symptoms among healthy individuals, and compare demographic, psychological and physical factors between individuals with and without symptoms. DESIGN: Cross-sectional observational study. METHOD: Data were from the 1000 Norms Project which recruited 1000 individuals aged 3-101 years...
March 23, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28351019/online-microdialysis-ultra-performance-liquid-chromatography-mass-spectrometry-method-for-comparative-pharmacokinetic-investigation-on-iridoids-from-gardenia-jasminoides-ellis-in-rats-with-different-progressions-of-type-2-diabetic-complications
#10
Xueju Zhang, Lu Wang, Zhong Zheng, Zifeng Pi, Zhiqiang Liu, Fengrui Song
Iridoid glycosides consist the main bioactive constituents of Gardenia jasminoides Ellis (G. jasminoides), which is used alone or in combination with other medicine herbs for treatment of diabetes mellitus in China. This paper investigated for the first time comparative pharmacokinetics (PKs) of four unbound iridoids (including genipin, geniposide, gardenoside and geniposidic acid) in rat blood between healthy and type 2 diabetic groups with different disease progressions (9 or 13 weeks). Online microdialysis-ultra performance liquid chromatography-mass spectrometry (MD- UPLC-MS/MS) method was used after oral administration of iridoid extracts obtained from the fruits of G...
March 21, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28351013/dynamics-of-antibiotic-resistance-genes-in-microbial-fuel-cell-coupled-constructed-wetlands-treating-antibiotic-polluted-water
#11
Shuai Zhang, Hai-Liang Song, Xiao-Li Yang, Shan Huang, Zhe-Qin Dai, Hua Li, Yu-Yue Zhang
Microbial fuel cell-coupled constructed wetlands (CW-MFCs) use electrochemical, biological, and ecological functions to treat wastewater. However, few studies have investigated the risks of antibiotic resistance genes (ARGs) when using such systems to remove antibiotics. Therefore, three CW-MFCs were designed to assess the dynamics of ARGs in filler biofilm and effluent over 5000 h of operation. The experimental results indicated that relatively high steady voltages of 605.8 mV, 613.7 mV, and 541.4 mV were obtained at total influent antibiotic concentrations of 400, 1,000, and 1600 μg L(-1), respectively...
March 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28351009/the-influence-of-citrate-and-oxalate-on-99-tc-vii-cs-np-v-and-u-vi-sorption-to-a-savannah-river-site-soil
#12
D Montgomery, K Barber, N Edayilam, K Oqujiuba, S Young, T Biotidara, A Gathers, M Danjaji, N Tharayil, N Martinez, B Powell
Batch sorption experiments were conducted with 0.5-50 ppb (99)Tc, (133)Cs, (237)Np and U in the presence and absence of citrate and/or oxalate in a 25 g/L Savannah River Site (SRS) soil suspension. Citrate and oxalate were the ligands of choice due to their relevancy to plant exudates, the nuclides were selected for their wide range of biogeochemical behavior, and the soil from SRS was selected as a model Department of Energy (DOE) site soil. Batch samples were continually mixed on a rotary shaker and maintained at a pH of approximately 5...
March 25, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28351004/temporal-changes-in-the-prevalence-of-disordered-eating-behaviors-among-adolescents-living-in-the-metropolitan-area-of-rio-de-janeiro-brazil
#13
Danilo Dias Santana, Erica Guimarães Barros, Rosana Salles da Costa, Gloria Valeria da Veiga
To investigate temporal changes in the prevalence of disordered eating behaviors among adolescents, and their association with socio demographic factors and overweight. Using probability sampling, two population-based cross-sectional surveys were conducted: one in 2005 (n=511) and the other in 2010 (n=314). The frequency of disordered eating behaviors (binge eating, strict dieting or fasting and compensatory behaviors) was investigated using a self-administered questionnaire. The presence of binge eating increased by 18...
March 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28351002/significance-of-lipoprotein-a-levels-in-familial-hypercholesterolemia-and-coronary-artery-disease
#14
Sha Li, Na-Qiong Wu, Cheng-Gang Zhu, Yan Zhang, Yuan-Lin Guo, Ying Gao, Xiao-Lin Li, Ping Qing, Chuan-Jue Cui, Rui-Xia Xu, Jing Sun, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND AND AIMS: Patients with familial hypercholesterolemia (FH) are often characterized by premature coronary artery disease (CAD) with heterogeneity at onset. The aim of the present study was to investigate the associations of lipoprotein (a) [Lp(a)] with the FH phenotype, genotype and roles of Lp(a) in determining CAD risk among patients with and without FH. METHODS: We enrolled 8050 patients undergoing coronary angiography, from our Lipid clinic. Clinical FH was diagnosed using the Dutch Lipid Clinic Network criteria...
March 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28351001/sample-size-bias-in-retrospective-estimates-of-average-duration
#15
Andrew R Smith, Shanon Rule, Paul C Price
People often estimate the average duration of several events (e.g., on average, how long does it take to drive from one's home to his or her office). While there is a great deal of research investigating estimates of duration for a single event, few studies have examined estimates when people must average across numerous stimuli or events. The current studies were designed to fill this gap by examining how people's estimates of average duration were influenced by the number of stimuli being averaged (i.e., the sample size)...
March 25, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28350998/anticancer-copper-ii-phosphorus-dendrimers-are-potent-proapoptotic-bax-activators
#16
Serge Mignani, Nabil El Brahmi, Laure Eloy, Joel Poupon, Valérie Nicolas, Anke Steinmetz, Said El Kazzouli, Mosto M Bousmina, Mireille Blanchard-Desce, Anne-Marie Caminade, Jean-Pierre Majoral, Thierry Cresteil
A multivalent phosphorus dendrimer 1G3 and its corresponding Cu-complex, 1G3-Cu have been recently identified as agents retaining high antiproliferative potency. This antiproliferative capacity was preserved in cell lines overexpressing the efflux pump ABC B1, whereas cross-resistance was observed in ovarian cancer cell lines resistant to cisplatin. Theoretical 3D models were constructed: the dendrimers appear as irregularly shaped disk-like nano-objects of about 22 Å thickness and 49 Å diameter, which accumulated in cells after penetration by endocytosis...
March 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28350995/the-difference-in-association-between-aspirin-use-and-other-thrombocyte-aggregation-inhibitors-and-survival-in-patients-with-colorectal-cancer
#17
M A Frouws, E Rademaker, E Bastiaannet, M P P van Herk-Sukel, V E Lemmens, C J H Van de Velde, J E A Portielje, G J Liefers
BACKGROUND: Several studies have suggested that the association between aspirin and improved cancer survival is mediated through the mechanism of aspirin as thrombocyte aggregation inhibitors (TAI). The aim of this study was to provide epidemiological evidence for this mechanism assessing the association between overall survival and the use of aspirin and non-aspirin TAI in patients with colorectal cancer. METHODS: In this observational study, data from the Netherlands Comprehensive Cancer Organisation were linked to PHARMO Database Network...
March 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28350992/expression-of-circadian-core-clock-genes-in-fibroblasts-of-human-gingiva-and-periodontal-ligament-is-modulated-by-l-mimosine-and-hypoxia-in-monolayer-and-spheroid-cultures
#18
Klara Janjić, Christoph Kurzmann, Andreas Moritz, Hermann Agis
OBJECTIVE: The circadian clock is involved in a plethora of physiological processes including bone formation and tooth development. While expression of circadian core clock genes was observed in various tissues, their role in the periodontium is unclear. We hypothesized that periodontal cells express circadian core clock genes and that their levels are modulated by hypoxia mimetic agents and hypoxia. MATERIAL AND METHODS: Fibroblasts of human gingiva (GF) and periodontal ligament (PDLF) in monolayer and spheroid cultures were treated with the hypoxia mimetic agent L-Mimosine (L-MIM) or hypoxia...
March 14, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28350990/the-putative-drp1-inhibitor-mdivi-1-is-a-reversible-mitochondrial-complex-i-inhibitor-that-modulates-reactive-oxygen-species
#19
Evan A Bordt, Pascaline Clerc, Brian A Roelofs, Andrew J Saladino, László Tretter, Vera Adam-Vizi, Edward Cherok, Ahmed Khalil, Nagendra Yadava, Shealinna X Ge, T Chase Francis, Nolan W Kennedy, Lora K Picton, Tanya Kumar, Sruti Uppuluri, Alexandrea M Miller, Kie Itoh, Mariusz Karbowski, Hiromi Sesaki, R Blake Hill, Brian M Polster
Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here, we show that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350966/cationic-phosphorus-dendrimer-enhances-photodynamic-activity-of-rose-bengal-against-basal-cell-carcinoma-cell-lines
#20
Monika Dabrzalska, Anna Janaszewska, Maria Zablocka, Serge Mignani, Jean Pierre Majoral, Barbara Klajnert-Maculewicz
In the last couple of decades, photodynamic therapy emerged as a useful tool in the treatment of basal cell carcinoma. However, it still meets limitations due to unfavorable properties of photosensitizers, such as poor solubility or lack of selectivity. Dendrimers - polymers widely studied in biomedical field - may play a role as photosensitizer carriers and improve the efficacy of photodynamic treatment. Here, we describe the evaluation of an electrostatic complex of cationic phosphorus dendrimer and rose bengal in such aspects as singlet oxygen production, cellular uptake and phototoxicity against three basal cell carcinoma cell lines...
March 28, 2017: Molecular Pharmaceutics
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