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https://www.readbyqxmd.com/read/29344570/use-of-anticoagulant-or-antiplatelet-agents-is-not-related-to-epistaxis-in-patients-undergoing-transnasal-endoscopy
#1
Yoshiya Kobayashi, Yoshinori Komazawa, Mika Yuki, Hitomi Ishitobi, Makoto Nagaoka, Yoshiko Takahashi, Sayaka Nakashima, Toshihiro Shizuku, Yoshikazu Kinoshita
Background and study aims : Unsedated transnasal endoscopy (uTNE) has become accepted as a safe and tolerable method for upper gastrointestinal tact examinations. Epistaxis is 1 of the major complications of TNE, though its risk factors have not been elucidated. Generally, patients administered an anticoagulant or antiplatelet drug are considered to have an increased risk of epistaxis during TNE. Here, we investigated risk factors of epistaxis in patients undergoing uTNE, with focus on those who received antithrombotic agents...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29344269/early-and-partial-reduction-in-cd4-foxp3-regulatory-t-cells-during-colitis-associated-colon-cancer-induces-cd4-and-cd8-t-cell-activation-inhibiting-tumorigenesis
#2
Jonadab E Olguín, Itzel Medina-Andrade, Emmanuel Molina, Armando Vázquez, Thalia Pacheco-Fernández, Rafael Saavedra, Carlos Pérez-Plasencia, Yolanda I Chirino, Felipe Vaca-Paniagua, Luis E Arias-Romero, Emma B Gutierrez-Cirlos, Sonia A León-Cabrera, Miriam Rodriguez-Sosa, Luis I Terrazas
Colorectal cancer (CRC) is the second most commonly diagnosed cancer in women and the third in men in North America and Europe. CRC is associated with inflammatory responses in which intestinal pathology is caused by different cell populations including a T cell dysregulation that concludes in an imbalance between activated T (Tact) and regulatory T (Treg) cells. Treg cells are CD4+Foxp3+ cells that actively suppress pathological and physiological immune responses, contributing to the maintenance of immune homeostasis...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29249918/sphenoethmoid-cell-the-battle-for-places-inside-of-the-nose-between-a-posterior-ethmoid-cell-and-sphenoid-sinus-3d-volumetric-quantification
#3
Mehmet Senturk, Ibrahim Guler, Isa Azgin, Engin Umut Sakarya, Ramazan Ocal, Betul Agirgol, Necat Alatas, Ismet Tolu, Mehmet Kilinc
Background: Sphenoethmoid cells may be above the sphenoid sinus with/ or without con-tact to optical nerve. Although sphenoethmoid cells are theoretically considered to possibly influence the sphenoid sinus volume, we could not find any study in the literature on this issue. Aims: The aim of our study was to detect sphenoethmoid cells and measure the sphenoid sinus vol-ume using multiplanar computerized tomography and also investigate the correlation between the presence of sphenoethmoid cells and the sphenoid sinus volume...
November 2017: Current Medical Imaging Reviews
https://www.readbyqxmd.com/read/29240858/a-novel-multifactorial-approach-to-developing-mild-laundry-detergents-and-assessing-their-relative-mildnes
#4
Joseph F Fowler, Matthew J Zirwa J Zirwas, Lisa Napolitano, Meghan Russell, Janet Coope-Epstein
<p>INTRODUCTION: Dermatologists are becoming more aware of the irritant and allergic potential of laundry detergents that incorporate harsh surfactants and potentially sensitizing ingredients. It is difficult however for the physician to distinguish one laundry detergent from another because the only distinguishing feature advertised tends to be the lack of dyes and fragrances.</p> <p>DESIGN: A new objective method was developed for measuring the harshness of laundry detergents using a three-pronged laboratory testing approach consisting of zein, corneosurfametry, and cytokine testing...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29224648/effect-of-high-dose-oral-multivitamins-and-minerals-in-participants-not-treated-with-statins-in-the-randomized-trial-to-assess-chelation-therapy-tact
#5
RANDOMIZED CONTROLLED TRIAL
Omar M Issa, Rhonda Roberts, Daniel B Mark, Robin Boineau, Christine Goertz, Yves Rosenberg, Eldrin F Lewis, Erminia Guarneri, Jeanne Drisko, Allan Magaziner, Kerry L Lee, Gervasio A Lamas
IMPORTANCE: In a prespecified subgroup analysis of participants not on statin therapy at baseline in the TACT, a high-dose complex oral multivitamins and multimineral regimen was found to have a large unexpected benefit compared with placebo. The regimen tested was substantially different from any vitamin regimen tested in prior clinical trials. OBJECTIVE: To explore these results, we performed detailed additional analyses of participants not on statins at enrollment in TACT...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29199412/evaluation-of-a-halitosis-clinic-over-a-period-of-eleven-years
#6
Marie-Gabrielle Schumacher, Andrea Zürcher, Andreas Filippi
About every fourth individual suffers at leasttemporarily from oral malodor. The most frequentcause of it is the oral cavity, in particular thetongue coating. In professional halitosis clinics,findings and diagnoses are discussed with thepatients, and individual therapy concepts are designed. Currently, there are only few ev alua- tions of such clinics, which moreover are con- fined to a period of a few weeks or months. The aim of the present work was to evaluate the halitosis clinic of the University Center of Dental Medicine Basel o ver a period of eleven years...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/29179731/can-routine-data-be-used-to-support-cancer-clinical-trials-a-historical-baseline-on-which-to-build-retrospective-linkage-of-data-from-the-tact-cruk-01-001-breast-cancer-trial-and-the-national-cancer-data-repository
#7
Lucy Suzanne Kilburn, Maria Aresu, Jane Banerji, Peter Barrett-Lee, Paul Ellis, Judith Margaret Bliss
BACKGROUND: Randomised clinical trials (RCTs) are the gold standard for evaluating new cancer treatments. They are, however, expensive to conduct, particularly where long-term follow-up of participants is required. Tracking participants via routine datasets could provide a cost-effective alternative for ascertaining follow-up information required to evaluate disease outcomes. This project explores the potential for routine data to inform cancer trials, using, the historical National Cancer Data Repository (NCDR) for English NHS sites and, for validation, mature data available from the TACT trial...
November 23, 2017: Trials
https://www.readbyqxmd.com/read/29161012/top-down-proteomics-ready-for-prime-time
#8
Bifan Chen, Kyle A Brown, Ziqing Lin, Ying Ge
In the post-genomics era, the study of proteins is critical for understanding cellular functions at the molecular level.1-5 Beyond the genetic code, the human proteome is greatly diversified by various genetic variations, alternative splicing of RNA transcripts, and post-translational modifi-cations (PTMs).6,7 In 2013, the term "proteoform" was designated to describe "all of the different molecular forms in which the protein product of a single gene can be found",6 clearing up the confusion in nomenclature and joining research efforts to develop methodologies for pro-teoform characterization...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29129003/chelation-therapy-as-a-cardiovascular-therapeutic-strategy-the-rationale-and-the-data-in-review
#9
REVIEW
Roy O Mathew, Joshua Schulman-Marcus, Elizabeth L Nichols, Jonathan D Newman, Sripal Bangalore, Michael Farkouh, Mandeep S Sidhu
Chelation therapy, typically used to remove heavy metal toxins, has also been controversially used as a treatment for coronary artery disease. The first Trial to Assess Chelation Therapy (TACT) aimed to provide evidence on chelation therapy's potential for benefit or harm. Although TACT had some significant results, the trial does not provide enough evidence to recommend routine chelation therapy and has limitations. The second TACT was recently funded reigniting a discussion about the value of chelation therapy, its efficacy, and allocation of research resources...
November 11, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29111699/investigation-of-trimethyllysine-binding-by-the-hp1-chromodomain-via-unnatural-amino-acid-mutagenesis
#10
Stefanie A Baril, Amber L Koenig, Mackenzie W Krone, Katherine I Albanese, Cyndi Qixin He, Ga Young Lee, Kendall N Houk, Marcey L Waters, Eric M Brustad
Trimethyllysine (Kme3) reader proteins are targets for inhibition due to their role in mediating gene expression. Although all such reader proteins bind Kme3 in an aromatic cage, the driving force for binding may differ; some readers exhibit evidence for cation-π interactions whereas others do not. We report a general unnatural amino acid mutagenesis approach to quantify the contribution of individual tyrosines to cation binding using the HP1 chromodomain as a model system. We demonstrate that two tyrosines (Y24 and Y48) bind to a Kme3-histone tail peptide via cation-π interactions, but linear free energy trends suggest they do not contribute equally to binding...
November 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29105757/transforming-the-activation-of-clinical-trials
#11
Julie T Watters, Jason H Pitzen, Linda J Sanders, Virginia Nickie M Bruce, Alissa R Cornell, Gary C Cseko, Janice S Grace, Pamela S Kwon, Andrea K Kukla, Michael S Lee, Michelle D Monosmith, John D Myren, Rebecca S Kottschade, Marc N Shaft, Jennifer Jenny A Weis, Jane C Welter, Adil E Bharucha
The Institute of Medicine and US Food and Drug Administration (FDA) recognize that activating clinical trials in the United States is lengthy and inefficient. Downstream consequences include increased expense, suboptimal accrual, move of clinical trials overseas, and delayed availability of treatments for patients. An in-tandem processing initiative is here highlighted that transformed the activation of clinical trials (TACT), reduced the activation time by 70%, and offers a paradigm for enhanced translational readiness...
January 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29083460/language-sensitivity-the-respect-model-and-continuing-education
#12
Dawn M Aycock, Traci T Sims, Terri Florman, Karis T Casseus, Paula M Gordon, Regena G Spratling
Some words and phrases used by health care providers may be perceived as insensitive by patients, which could negatively affect patient outcomes and satisfaction. However, a distinct concept that can be used to describe and synthesize these words and phrases does not exist. The purpose of this article is to propose the concept of language sensitivity, defined as the use of respectful, supportive, and caring words with consideration for a patient's situation and diagnosis. Examples of how language sensitivity may be lacking in nurse-patient interactions are described, and solutions are provided using the RESPECT (Rapport, Environment/Equipment, Safety, Privacy, Encouragement, Caring/Compassion, and Tact) model...
November 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/29077540/toward-reduction-in-antibiotic-use-for-pediatric-otitis-media-predicting-parental-compliance-with-watchful-waiting-advice
#13
Erina L MacGeorge, Rachel A Smith, Emily P Caldes, Nicole M Hackman
"Watchful waiting" (WW) can reduce unnecessary antibiotic use in the treatment of pediatric otitis media (ear infection), but the utility of the strategy is impaired by underutilization and noncompliance. Guided by advice response theory (ART), the current study examines how parental compliance with WW and trust in the prescribing physician is predicted by evaluative and affective responses to the advice. Parents (N = 134) of at least one child aged 5 years or younger completed questionnaires that assessed responses to WW advice they received for their youngest child...
November 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/29021945/an-evaluation-of-instructive-feedback-to-teach-play-behavior-to-a-child-with-autism-spectrum-disorder
#14
Laura L Grow, Tiffany Kodak, Andrea Clements
Instructive feedback is used to expose learners to secondary targets during skill acquisition programs (Reichow & Wolery, in Journal of Applied Behavior Analysis, 44, 327-340, 2011; Werts, Wolery, Gast, & Holcombe, in Journal of Behavioral Education, 5, 55-75, 1995). Although unrelated feedback may have clinical utility in practice, very little research has evaluated unrelated instructive feedback, particularly for promoting play behavior (Colozzi, Ward, & Crotty, in Education and Training in Developmental Disabilities, 43, 226-248, 2008)...
September 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/28980796/mechanism-of-surface-enhanced-raman-scattering-based-on-3d-graphene-tio2-nanocomposites-and-application-to-real-time-monitoring-of-telomerase-activity-in-differentiation-of-stem-cells
#15
Tingting Zheng, Enduo Feng, Zhiqiang Wang, Xueqing Gong, Yang Tian
With a burst development of new nanomaterials for plasmon-free surface-enhanced Raman scattering (SERS), the understanding of chemical mechanism (CM) and further applications have become more and more attractive. Herein, a novel SERS platform was specially designed through electrochemical deposition of graphene onto TiO2 nanoarrays (EG-TiO2). The developed EG-TiO2 nanocomposite SERS platform possessed remarkable Raman activity using copper phthalocyanine (CuPc) as a probe molecule. X-ray photoelectron spectroscopy measurement revealed that the chemical bond Ti-O-C was formed at the interface between graphene and TiO2 in EG-TiO2 nanocomposites...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28976141/population-specific-genetic-variation-at-microrna-629-binding-site-in-the-3-utr-of-nbs1-gene-in-prostate-cancer-patients
#16
Ammad Ahmad Farooqi, Syed M Kamran Majeed, Qaisar Mansoor, Muhammad Ismail
OBJECTIVE: Prostate cancer is a genomically complex disease and recently emerging scientific evidence is adding new pieces of information into existing pool of knowledge of oncology. Prostate cancer cells tactfully rewire signaling cascades in presence or absence of androgen. We do not have finer proteome and genome based patient related information of our cancer patients. METHODOLOGY: In the present laboratory research, we studied 3' UTR C/T and A/G polymorphism in NBS1 gene in 100 prostate cancer patients and 100 healthy individuals without any previous clinical history, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28941941/novel-toxins-from-type-ii-toxin-antitoxin-systems-with-acetyltransferase-activity
#17
REVIEW
Dukas Jurėnas, Abel Garcia-Pino, Laurence Van Melderen
Type II toxin-antitoxin (TA) systems are widespread in bacterial and archeal genomes. These modules are very dynamic and participate in bacterial genome evolution through horizontal gene transfer. TA systems are commonly composed of a labile antitoxin and a stable toxin. Toxins appear to preferentially inhibit the protein synthesis process. Toxins use a variety of molecular mechanisms and target nearly every step of translation to achieve their inhibitory function. This review focuses on a recently identified TA family that includes acetyltransferase toxins...
September 20, 2017: Plasmid
https://www.readbyqxmd.com/read/28940365/teaching-metaphorical-extensions-of-private-events-through-rival-model-observation-to-children-with-autism
#18
Mark R Dixon, Jordan Belisle, Bridget E Munoz, Caleb R Stanley, Kyle E Rowsey
The study evaluated the efficacy of observational learning using the rival-model technique in teaching three children with autism to state metaphorical statements about emotions when provided a picture, as well as to intraverbally state an appropriate emotion when provided a scenario and corresponding metaphorical emotion. The results provide a preliminary evaluation of how an observational teaching strategy may be effective in teaching children with autism to correctly tact emotions when given metaphors.
October 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28868260/tpoab-and-thyroid-function-are-not-associated-with-breast-cancer-outcome-evidence-from-a-large-scale-study-using-data-from-the-taxotere-as-adjuvant-chemotherapy-trial-tact-cruk01-001
#19
Ilaria Muller, Lucy S Kilburn, Peter N Taylor, Peter J Barrett-Lee, Judith M Bliss, Paul Ellis, Marian E Ludgate, Colin M Dayan
BACKGROUND: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. OBJECTIVES: We aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). METHODS: TACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1-3a, pN0-1, M0), with stored plasma (n = 1,974), taken 15...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28852775/natural-agents-mediated-targeting-of-histone-deacetylases
#20
REVIEW
Ammad Ahmad Farooqi, Syed Kamran-Ul-Hassan Naqvi, Aliye Aras Perk, Onur Yanar, Sobia Tabassum, Muhammad Sheeraz Ahmad, Qaisar Mansoor, Mohamed S Ashry, Muhammad Ismail, George E Naoum, Waleed O Arafat
In the past few years, basic and clinical scientists have witnessed landmark achievements in many research projects, such as those conducted by the US National Institutes of Health Roadmap Epigenomics Mapping Consortium, the International Human Epigenome Consortium, The Cancer Genome Atlas Network and the International Cancer Genome Consortium, which have provided near-complete resolution of epigenetic landscape in different diseases. Furthermore, genome sequencing of tumors has provided compelling evidence related to frequent existence of mutations in readers, erasers and writers of epigenome in different cancers...
August 30, 2017: Archivum Immunologiae et Therapiae Experimentalis
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