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Petar S Djuric, Aleksandar Jankovic, Jovan Popovic, Jelena Tosic Dragovic, Ana Bulatovic, Zivka Djuric, Milos Mitrovic, Nada Dimkovic
INTRODUCTION:  Patients on dialysis have a high rate of death, mainly of cardiovascular cause. Nephrologists are actively looking for ways to improve patients' outcomes, and alternative dialysis strategies, such as long conventional hemodialysis and hemodiafiltration, are currently being investigated. The aim of this study was to compare anemia, nutrition, inflammation, mineral metabolism, and 3-year survival rates between patients treated with hemodiafiltration and prolonged high-flux hemodialysis (HFH)...
November 2016: Iranian Journal of Kidney Diseases
Deborah A DeMeester
BACKGROUND: The dedicated education unit (DEU) was developed as an innovation to increase enrollment capacity and secure stable clinical placement sites in units that provide an optimal learning environment. The purpose of this multisite study was to describe, interpret, and offer insight into the meanings of the lived experiences of nursing faculty who had transitioned to teaching in a DEU. METHOD: Semistructured private interviews were conducted using an interpretive phenomenological approach...
December 1, 2016: Journal of Nursing Education
Nooshin Mohandesi, Kamahldin Haghbeen, Omid Ranaei, Seyed Shahriar Arab, Sorour Hassani
Engineering of invertases has come to attention because of increasing demand for possible applications of invertases in various industrial processes. Due to the known physicochemical properties, invertases from micro-organisms such as Saccharomyces cerevisiae carrying SUC2 gene are considered as primary models. To improve thermostability and catalytic efficiency of SUC2 invertase (SInv), six influential residues with Relative Solvent Accessibility<5% were selected through multiple-sequence alignments, molecular modelling, structural and computational analyses...
January 2017: Enzyme and Microbial Technology
J Murgier, J-F Coste, E Cavaignac, X Bayle-Iniguez, P Chiron, P Bonnevialle, J-M Laffosse
INTRODUCTION: Cell-phones are the typical kind of object brought into the operating room from outside by hospital staff. A great effort is made to reduce the level of potentially contaminating bacteria in the operating room, and introducing these devices may run counter to good practice. The study hypothesis was that cell-phones are colonized by several strains of bacteria and may constitute a source of nosocomial contamination. The main study objective was to screen for bacterial colonies on the surfaces of cell-phones introduced in an orthopedic surgery room...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Deming Chen, Guobao Li, Xiangdong Fu, Pei Li, Jie Zhang, Lan Luo
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis (MTB), is one of the global public health catastrophes. Wnt signaling has recently been identified to exert immunoregulatory functions in a variety of inflammatory and infectious diseases, including tuberculosis. The opposite expression of Wnt5a in human and mice during MTB infection drives us to explore the roles and biological significances of reduced Wnt5a for MTB-treated mice. In our study, the reduction of WNT5A in MTB-treated mice lung tissues or MTB-infected mice bone marrow-derived macrophages (BM-Mø) was in a dose- and time-dependent manner...
November 9, 2016: DNA and Cell Biology
Ehimen C Aneni, Esteban Escolar, Gervasio A Lamas
Over the last few decades, there has been a growing body of epidemiologic evidence linking chronic toxic metal exposure to cardiovascular disease-related morbidity and mortality. The recent and unexpectedly positive findings from a randomized, double-blind, multicenter trial of metal chelation for the secondary prevention of atherosclerotic cardiovascular disease (Trial to Assess Chelation Therapy (TACT)) have focused the discussion on the role of chronic exposure to toxic metals in the development and propagation of cardiovascular disease and the role of toxic metal chelation therapy in the secondary prevention of cardiovascular disease...
December 2016: Current Atherosclerosis Reports
Maryam Rezazadeh, Hamid Baghchesaraei, Amir Peymani
OBJECTIVES: Escherichia coli is regarded as the most important etiological agent of urinary tract infections. Fluoroquinolones are routinely used in the treatment of these infections; however, in recent years, a growing rate of resistance to these drugs has been reported globally. The aims of this study were to detect plasmid-mediated qnrA, qnrB, and qnrS genes among the quinolone-nonsusceptible E. coli isolates and to investigate their clonal relatedness in Qazvin and Zanjan Provinces, Iran...
October 2016: Osong Public Health and Research Perspectives
Sher Bahader Khan, Shahid Ali Khan, Tahseen Kamal, Abdullah M Asiri, Kalsoom Akhtar
BACKGROUND: Potable, clean and safe water is the basic need for all human beings. Major portion of the earth is occupied by water, however, this is contaminated by rapid industrialization, improper sewage and natural calamities and man-made activates, which produce several water-borne and fetal diseases. In this review we presented some recent patent for environmental remediation. METHODS: Various technologies have been developed for the treatment of waste water consist of chemical, membrane, filtration, sedimentation, chlorination, disinfection, electrodialysis, electrolysis, reverse osmosis and adsorption...
October 25, 2016: Recent Patents on Nanotechnology
Wen-Chih Huang, Chien-Chen Tsai, Chih-Chieh Chan
BACKGROUND/PURPOSE: Cholangiocarcinoma (CC) is a fatal malignancy originating from biliary tracts and constitutes approximately 10-20% of hepatobiliary cancers. CC is characterized by a very poor prognosis. The definite molecular mechanisms leading to oncogenesis remain unclear. This study aimed to perform mutation analysis and copy number changes of KRAS and BRAF genes of CC in Taiwan. METHODS: A total of 182 cases of biliary tact CC were studied for point mutation and quantitative real-time polymerase chain reaction analysis of KRAS and BRAF genes...
October 10, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Christine Gonzales, Hikari A I Yoshihara, Nahzli Dilek, Julie Leignadier, Melita Irving, Pascal Mieville, Lothar Helm, Olivier Michielin, Juerg Schwitter
BACKGROUND: 19F-MRI and 19F-MRS can identify specific cell types after in-vitro or in-vivo 19F-labeling. Knowledge on the potential to track in-vitro 19F-labeled immune cells in tumor models by 19F-MRI/MRS is scarce. AIM: To study 19F-based MR techniques for in-vivo tracking of adoptively transferred immune cells after in-vitro 19F-labeling, i.e. to detect and monitor their migration non-invasively in melanoma-bearing mice. METHODS: Splenocytes (SP) were labeled in-vitro with a perfluorocarbon (PFC) and IV-injected into non-tumor bearing mice...
2016: PloS One
K Conallen, P Reed
BACKGROUND: Two procedures were developed to teach individuals with Autism Spectrum Disorders labels (tacts) for various private events (emotions): Study 1 attempted to distinguish them from pure tacts and mands (requests); and Study 2 attempted to train initiating a conversation with grammatically correct subject-verb-comment construction. METHODS: A multiple treatment reversal design was used in both studies, followed by a probe to see if the tacts were used across novel settings...
October 10, 2016: Journal of Intellectual Disability Research: JIDR
Marni S Crow, Krystal K Lum, Xinlei Sheng, Bokai Song, Ileana M Cristea
In mammalian cells, early defenses against infection by pathogens are mounted through a complex network of signaling pathways shepherded by immune-modulatory pattern-recognition receptors. As obligate parasites, the survival of viruses is dependent on the evolutionary acquisition of mechanisms that tactfully dismantle and subvert the cellular intrinsic and innate immune responses. Here, we review the diverse mechanisms by which viruses that accommodate DNA genomes are able to circumvent activation of cellular immunity...
September 21, 2016: Critical Reviews in Biochemistry and Molecular Biology
Dean P Smith, Svein Eikeseth, Sarah E Fletcher, Lisa Montebelli, Holly R Smith, Jennifer C Taylor
The purpose of the present study was to assess whether intraverbal behavior, in the form of answers to questions, emerges as a result of listener training for five children diagnosed with autism. Listener responses were targeted and taught using prompting and differential reinforcement. Following successful acquisition of listener responses, the intraverbal form of the response was probed. Data were evaluated via a nonconcurrent multiple-baseline design that included a control series. Results showed listener-to-intraverbal transfer for four of the five participants...
June 2016: Analysis of Verbal Behavior
Joseph Vedora, Erin Conant
Several researchers have compared the effectiveness of tact or textual prompts to echoic prompts for teaching intraverbal behavior to young children with autism. We extended this line of research by comparing the effectiveness of visual (textual or tact) prompts to echoic prompts to teach intraverbal responses to three young adults with autism. An adapted alternating treatments design was used with 2 to 3 comparisons for each participant. The results were mixed and did not reveal a more effective prompting procedure across participants, suggesting that the effectiveness of a prompting tactic may be idiosyncratic...
October 2015: Analysis of Verbal Behavior
James R Mellor, Clarissa S Barnes, Ruth Anne Rehfeldt
The current research investigated whether intraverbals would emerge following auditory tact instruction. Participants were first taught to tact auditory stimuli by providing the name of the item or animal that produces the sound (e.g., saying "eagle" when presented with the recording of an eagle cawing). Following test probes for simple intraverbals as well as intraverbal categorization participants were taught to tact what each auditory stimulus is (e.g., saying "caw" when presented with the recording of an eagle cawing)...
October 2015: Analysis of Verbal Behavior
Audrey A Pauwels, William H Ahearn, Stacy J Cohen
Foss (Journal of Experimental Psychology, 76, 450-459, 1968a; Journal of Experimental Psychology, 77, 341-344, 1968b) compared overlap and non-overlap instruction to promote recombinative response generalization using a matrix training procedure. In the present study, we used a similar set of procedures to teach tacting of kitchen items and prepositions (i.e., relational autoclitics) to three females ages 13-20, diagnosed with autism spectrum disorder. We taught some kitchen items/prepositions as tacts (e.g...
October 2015: Analysis of Verbal Behavior
Patricia M Santos, Monica L Ma, Caio F Miguel
The current study evaluated whether training intraverbal naming would be sufficient to establish visual-visual matching-to-sample (MTS) performances in college students. In the first experiment, we used a multiple-probe design across stimulus sets to assess whether six participants could match arbitrary visual stimuli (AB) after learning to tact their two experimentally defined classes (A' and B') and then intraverbally relate their names (i.e., "A' goes with B'"). All participants matched the stimuli accurately after training, as well as emitted the trained intraverbals...
October 2015: Analysis of Verbal Behavior
Nathaniel T Kim, Haixing Li, Latha Venkataraman, James L Leighton
A highly conducting electronic contact between a strained disilane and Au is demonstrated through scanning tunneling microscope-based single-molecule measurements. Conformationally locked cis diastereomers of bis(sulfide)-anchor-equipped 1,2-disilaacenaphthenes readily form high-conducting junctions in which the two sulfide anchors bind in a bipodal fashion to one gold electrode, providing enough stability for a stable electrical contact between the Si-Si σ bond and the other electrode.
September 14, 2016: Journal of the American Chemical Society
Patrick Müller, Vladimir Ivanov, Kaffer Kara, Oliver Klein-Wiele, Mathias Forkmann, Christopher Piorkowski, Christian Blockhaus, Dimitrios Dimitroulis, Shazia Afzal, Dong-In Shin, Malte Kelm, Hisaki Makimoto, Andreas Mügge
BACKGROUND: Insertable cardiac monitor (ICM) increases the detection rate of occult atrial fibrillation (AF) after cryptogenic stroke. The aim of this study was to evaluate the prognostic significance of total atrial conduction time (TACT) assessed by tissue Doppler imaging (PA-TDI interval) to predict AF presence in patients with cryptogenic stroke. METHODS: Ninety patients (57.7 ± 12.3 years, 48 % women) after acute cryptogenic stroke and ICM implantation were prospective recruited at four centers for continuous rhythm monitoring...
August 19, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
F Ahour, M K Ahsani
In this work, we tactfully constructed a novel label-free electrochemical aptasensor for rapid and facile detection of thrombin using graphene oxide (GO) and thrombin binding aptamer (TBA). The strategy relies on the preferential adsorption of single-stranded DNA (ssDNA) to GO over aptamer-target complexes. The TBA-thrombin complex formation was monitored by differential pulse voltammetry (DPV) using the guanine oxidation signal. In the absence of thrombin, the aptamers adsorbed onto the surface of GO leading to a strong background guanine oxidation signal...
December 15, 2016: Biosensors & Bioelectronics
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