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https://www.readbyqxmd.com/read/28645200/prognostic-awareness-prognostic-communication-and-cognitive-function-in-patients-with-malignant-glioma
#1
Eli L Diamond, Holly G Prigerson, Denise C Correa, Anne Reiner, Katherine Panageas, Maria Kryza-Lacombe, Justin Buthorn, Elizabeth C Neil, Alex M Miller, Lisa M DeAngelis, Allison J Applebaum
Background: Malignant glioma (MG) is a devastating neuro-oncologic disease with almost invariably poor prognosis. Prognostic awareness (PA) is the awareness of incurable disease and shortened life-expectancy (LE). Accurate PA is associated with favorable psychological outcomes at the end-of-life (EOL) for patients with cancer, however little is known about PA or prognostic communication in MG. Moreover, research has yet to evaluate the impact of cognitive impairment on PA and preferred forms of communication...
June 22, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28645043/in-vitro-and-in-vivo-behavior-of-dna-tetrahedrons-as-tumor-targeting-nanocarriers-for-doxorubicin-delivery
#2
Ji Hee Kang, Kyoung-Ran Kim, Hyukjin Lee, Dae-Ro Ahn, Young Tag Ko
Deoxyribonucleic acid (DNA) is a versatile material with high applicability and inherent biocompatibility. L-DNA, the perfect mirror form of the naturally occurring D-DNA, has been used in DNA nanotechnology. It has thermodynamically identical properties to D-DNA, is capable of self-assembly and bio-orthogonal base-pairing, and is resistant to nuclease activity. We previously constructed an L-DNA tetrahedron (L-Td) and found that this nanostructure has remarkably higher capacity for cell penetration than its natural counterpart (D-Td)...
June 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28645001/a-role-for-visceral-feedback-and-interoception-in-feelings-of-knowing
#3
Chris M Fiacconi, Jane E Kouptsova, Stefan Köhler
Guided by the framework that autonomic feedback shapes emotional experience and other feeling states, we asked whether feeling-of-knowing (FOK) judgments may be influenced by visceral information through interoception. Participants performed a FOK task for previously studied face-name pairs while changes in cardiovascular and facial muscle activity were recorded. Previously studied face cues for which the corresponding name could not be recalled elicited an increased cardiac rate relative to novel face cues...
June 20, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28644985/depressive-like-behavior-is-elevated-among-offspring-of-parents-exposed-to-dim-light-at-night-prior-to-mating
#4
Yasmine M Cissé, Kathryn L G Russart, Randy J Nelson
Rates of major depressive disorder (MDD) have steadily increased over the past 50 years. Many factors have been implicated in the etiology of depressive disorders and environmental influences are being increasingly recognized. The increase in depression rates has coincided with increased artificial nighttime lighting. Exposure to light at night (LAN) has been associated with increased depressive-like behavior in rodents and decreased mood in humans. However, relatively little is known on the multigenerational effects of dLAN on affect...
June 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28644944/change-in-the-distance-from-the-axillary-nerve-to-the-glenohumeral-joint-with-shoulder-external-rotation-or-abduction-position
#5
Juan Pablo Simone, Philipp N Streubel, Joaquin Sanchez-Sotelo, Scott P Steinmann, Julie E Adams
BACKGROUND: This study investigated whether axillary nerve (AN) distance to the inferior border of the humeral head and inferior glenoid would change while placing the glenohumeral joint in different degrees of external rotation and abduction. METHODS: A standard deltopectoral approach was performed on 10 fresh-frozen cadaveric specimens. The distance between AN and the inferior border of the humeral head and inferior glenoid while placing the shoulder in 0°, 45°, and 90° of external rotation or abduction was measured...
July 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28644873/circular-rna-expression-profiling-of-human-granulosa-cells-during-maternal-aging-reveals-novel-transcripts-associated-with-assisted-reproductive-technology-outcomes
#6
Jing Cheng, Jia Huang, Suzhen Yuan, Su Zhou, Wei Yan, Wei Shen, Yun Chen, Xi Xia, Aiyue Luo, Da Zhu, Shixuan Wang
Circular RNAs (circRNAs) are a unique class of endogenous RNAs which could be used as potential diagnostic and prognostic biomarkers of many diseases. Our study aimed to investigate circRNA profiles in human granulosa cells (GCs) during maternal aging and to uncover age-related circRNA variations that potentially reflect decreased oocyte competence. CircRNAs in GCs from in vitro fertilization (IVF) patients with young age (YA, ≤ 30 years) and advanced age (AA, ≥ 38 years) were profiled by microarray, and validated in 20 paired samples...
2017: PloS One
https://www.readbyqxmd.com/read/28644855/comparison-of-the-mirna-expression-profiles-in-fresh-frozen-and-formalin-fixed-paraffin-embedded-tonsillar-tumors
#7
Zuzana Vojtechova, Jiri Zavadil, Jan Klozar, Marek Grega, Ruth Tachezy
MicroRNAs are considered as promising prognostic and diagnostic biomarkers of human cancer since their profiles differ between tumor types. Most of the tumor profiling studies were performed on rarely available fresh frozen (FF) samples. Alternatively, archived formalin-fixed paraffin-embedded (FFPE) tissue samples are also well applicable to larger-scale retrospective miRNA profiling studies. The aim of this study was to perform systematic comparison of the miRNA expression profiles between FF and macrodissected FFPE tonsillar tumors using the TaqMan Low Density Array system, with the data processed by different software programs and two types of normalization methods...
2017: PloS One
https://www.readbyqxmd.com/read/28644832/parent-child-discrepancies-in-the-report-of-adolescent-emotional-and-behavioral-problems-in-taiwan
#8
Ying-Yeh Chen, Suk-Yin Ho, Pei-Chen Lee, Chia-Kai Wu, Susan Shur-Fen Gau
The majority of studies on parent-child discrepancies in the assessment of adolescent emotional and behavioral problems have been conducted in Western countries. It is believed that parent-adolescent agreement would be higher in societies with a strong culture of familism. We examined whether parent-adolescent discrepancies in the rating of adolescent emotional and behavioral problems are related to parental and family factors in Taiwan. Participants included 1,421 child-parent pairs of 7th-grade students from 12 middle schools in Northern Taiwan and their parents...
2017: PloS One
https://www.readbyqxmd.com/read/28644827/what-drives-cooperative-breeding
#9
Walter D Koenig
Cooperative breeding, in which more than a pair of conspecifics cooperate to raise young at a single nest or brood, is widespread among vertebrates but highly variable in its geographic distribution. Particularly vexing has been identifying the ecological correlates of this phenomenon, which has been suggested to be favored in populations inhabiting both relatively stable, productive environments and in populations living under highly variable and unpredictable conditions. Griesser et al. provide a novel approach to this problem, performing a phylogenetic analysis indicating that family living is an intermediate step between nonsocial and cooperative breeding birds...
June 23, 2017: PLoS Biology
https://www.readbyqxmd.com/read/28644806/discriminative-deep-metric-learning-for-face-and-kinship-verification
#10
Jiwen Lu, Junlin Hu, Yap-Peng Tan
This paper presents a new discriminative deep metric learning (DDML) method for face and kinship verification in wild conditions. While metric learning has achieved reasonably good performance in face and kinship verification, most existing metric learning methods aim to learn a single Mahalanobis distance metric to maximize the inter-class variations and minimize the intra-class variations, which cannot capture the nonlinear manifold where face images usually lie on. To address this, we propose a DDML method to train a deep neural network to learn a set of hierarchical nonlinear transformations to project face pairs into the same latent feature space, under which the distance of each positive pair is reduced and that of each negative pair is enlarged, respectively...
June 20, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28644798/joint-alignment-of-multiple-point-sets-with-batch-and-incremental-expectation-maximization
#11
Dimitrios Georgios Evangelidis, Radu Horaud
This paper addresses the problem of registering multiple point sets. Solutions to this problem are often approximated by repeatedly solving for pairwise registration, which results in an uneven treatment of the sets forming a pair: a model set and a data set. The main drawback of this strategy is that the model set may contain noise and outliers, which negatively affects the estimation of the registration parameters. In contrast, the proposed formulation treats all the point sets on an equal footing. Indeed, all the points are drawn from a central Gaussian mixture, hence the registration is cast into a clustering problem...
June 21, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28644636/path-controlled-time-reordering-of-paired-photons-in-a-dressed-three-level-cascade
#12
Samir Bounouar, Max Strauß, Alexander Carmele, Peter Schnauber, Alexander Thoma, Manuel Gschrey, Jan-Hindrik Schulze, André Strittmatter, Sven Rodt, Andreas Knorr, Stephan Reitzenstein
The two-photon dressing of a "three-level ladder" system, here the ground state, the exciton, and the biexciton of a semiconductor quantum dot, leads to new eigenstates and allows one to manipulate the time ordering of the paired photons without unitary postprocessing. We show that, after spectral postselection of the single dressed states, the time ordering of the cascaded photons can be removed or conserved. Our joint experimental and theoretical study demonstrates the high potential of a "ladder" system to be a versatile source of orthogonally polarized, bunched or antibunched pairs of photons...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644579/pairing-field-methods-to-improve-inference-in-wildlife-surveys-while-accommodating-detection-covariance
#13
John Clare, Shawn T McKinney, John E DePue, Cynthia S Loftin
It is common to use multiple field sampling methods when implementing wildlife surveys to compare method efficacy or cost-efficiency, integrate distinct pieces of information provided by separate methods, or evaluate method-specific biases and misclassification error. Existing models that combine information from multiple field methods or sampling devices permit rigorous comparison of method-specific detection parameters, enable estimation of additional parameters such as false-positive detection probability, and improve occurrence or abundance estimates, but with the assumption that the separate sampling methods produce detections independently of one another...
June 23, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28644567/reliability-of-surface-emg-measurements-from-the-suprahyoid-muscle-complex
#14
Mohit Kothari, Peter William Stubbs, Asger Roer Pedersen, Jim Jensen, Jørgen Feldbaek Nielsen
BACKGROUND: Assessment of swallowing musculature using motor evoked potentials (MEPs) can be used to evaluate neural pathways. However, recording of the swallowing musculature is often invasive, uncomfortable and unrealistic in normal clinical practise. OBJECTIVE: To investigate the possibility of using the suprahyoid muscle complex (SMC) using surface electromyography (sEMG) to assess changes to neural pathways by determining the reliability of measurements in healthy participants over days...
June 23, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28644563/gas-phase-dissociation-study-of-erythrinian-alkaloids-by-electrospray-ionization-mass-spectrometry-and-computational-methods
#15
T Guaratini, L G P Feitosa, D B Silva, N P Lopes, J L C Lopes, R Vessecchi
Alkaloids from plants of the genus Erythrina display important biological activities, including anxiolytic action. Characterization of these alkaloids by mass spectrometry (MS) has contributed to the construction of a spectral library, has improved understanding of their structures, and has supported the proposal of fragmentation mechanisms in light of density functional calculations (DFT). In this study, we have used low- and high-resolution MS(n) analyses to investigate the fragmentation patterns of erythrinian alkaloids; we have employed the B3LYP/6-31+G(d,p) model to obtain their reactive sites...
June 23, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28644540/cytokeratin-19-expression-in-early-oral-squamous-cell-carcinoma-and-their-metastasis-inadequate-biomarker-for-one-step-nucleic-acid-amplification-implementation-in-sentinel-lymph-node-biopsy-procedure
#16
Rob Noorlag, Robert J J van Es, Remco de Bree, Stefan M Willems
BACKGROUND: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step nucleic acid amplification rapidly detects cytokeratin 19 (CK19) RNA with high accuracy. Sensitivity and specificity of CK19 expression in OSCC was evaluated. METHODS: Immunohistochemical CK19 expression was done in 207 patients with OSCC with 65 cases of paired nodal metastases...
June 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28644497/novel-tunable-green-red-emitting-oxynitride-phosphors-co-activated-with-ce-3-tb-3-and-eu-3-photoluminescence-and-energy-transfer
#17
Jiansheng Huo, Langping Dong, Wei Lü, Baiqi Shao, Hongpeng You
A series of novel Ce(3+), Tb(3+) and Eu(3+) ion doped Y4SiAlO8N-based oxynitride phosphors were synthesized by the solid-state method and characterized by X-ray powder diffraction, scanning electron microscopy, photoluminescence, lifetimes and thermo-luminescence. The excitation of the Ce(3+)/Tb(3+) co-doped and Ce(3+)/Tb(3+)/Eu(3+) tri-doped phosphor with near-UV radiation results in strong linear Tb(3+) green and Eu(3+) red emission. The occurrence of Ce(3+)-Tb(3+) and Ce(3+)-Tb(3+)-Eu(3+) energy transfer processes is responsible for the bright green or red luminescence...
June 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28644488/linear-nonequilibrium-thermodynamics-of-reversible-periodic-processes-and-chemical-oscillations
#18
Thomas Heimburg
Onsager's phenomenological equations successfully describe irreversible thermodynamic processes. They assume a symmetric coupling matrix between thermodynamic fluxes and forces. It is easily shown that the antisymmetric part of a coupling matrix does not contribute to dissipation. Therefore, entropy production is exclusively governed by the symmetric matrix even in the presence of antisymmetric terms. In this paper we focus on the antisymmetric contributions which describe isentropic oscillations with well-defined equations of motion...
June 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28644440/lncrna-sarcc-suppresses-renal-cell-carcinoma-rcc-progression-via-altering-the-androgen-receptor-ar-mirna-143-3p-signals
#19
Wei Zhai, Yin Sun, Changcheng Guo, Guanghui Hu, Mingchao Wang, Jiayi Zheng, WanYing Lin, Qingbo Huang, Gonghui Li, Junhua Zheng, Chawnshang Chang
While the androgen receptor (AR) might promote renal cell carcinoma (RCC) initiation and progression, the molecular mechanisms involved remain largely unclear. Here, we discovered the novel LncRNA-SARCC, which was suppressed and associated with better prognosis in RCC. Preclinical studies using multiple RCC cells and in vivo mouse model indicated that LncRNA-SARCC could attenuate RCC cell invasion, migration and proliferation in vitro and in vivo. Mechanistically, LncRNA-SARCC bound and destabilized AR protein with an inhibition of AR function, which led to transcriptionally de-repress miR-143-3p expression, thus inhibition of its downstream signals including AKT, MMP-13, K-RAS and P-ERK...
June 23, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28644401/the-investigation-of-electrochemistry-behaviors-of-tyrosinase-based-on-directly-electrodeposited-grapheneon-choline-gold-nanoparticles
#20
Yaping He, Xiaohui Yang, Quan Han, Jianbin Zheng
A novel catechol (CA) biosensor was developed by embedding tyrosinase (Tyr) onto in situ electrochemical reduction graphene (EGR) on choline-functionalized gold nanoparticle (AuNPs-Ch) film. The results of UV-Vis spectra indicated that Tyr retained its original structure in the film, and an electrochemical investigation of the biosensor showed a pair of well-defined, quasi-reversible redox peaks with Epa = -0.0744 V and Epc = -0.114 V (vs. SCE) in 0.1 M, pH 7.0 sodium phosphate-buffered saline at a scan rate of 100 mV/s...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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