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https://www.readbyqxmd.com/read/29346828/dynamic-posterior-stabilization-versus-posterior-lumbar-intervertebral-fusion-a-matched-cohort-study-based-on-the-spine-tango-registry
#1
Kathrin S Bieri, Kelly Goodwin, Emin Aghayev, Hans-Joachim Riesner, Ralph Greiner-Perth
PURPOSE:  The primary aim of dynamic stabilization is to stabilize the spine and preserve function without overstressing adjacent segments, which is a potential risk of fusion surgery. However, direct comparative analyses of the two approaches are still limited, and little is known about the association of patient-reported outcomes with these treatment options. OBJECTIVE:  To compare the clinical outcomes of dynamic posterior stabilization using the DSS Stabilization System (Paradigm Spine, LLC, New York, New York, United States) versus posterior lumbar intervertebral fusion (PLIF) based on data from a spine registry...
January 18, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29346737/quantitative-and-qualitative-assessment-of-the-relative-arterial-contributions-to-the-calcaneus
#2
Johanna C E Donders, Craig E Klinger, Andre D Shaffer, Lionel E Lazaro, Ryan R Thacher, Jonathan P Dyke, David S Wellman, David L Helfet, Dean G Lorich
BACKGROUND: The purpose of this study was to quantitatively and qualitatively assess relative arterial contributions to the calcaneus. METHOD: Fourteen cadaveric ankle pairs were used. In each specimen, the posterior tibial artery, peroneal artery, and anterior tibial artery were cannulated and used for contrast-enhanced magnetic resonance imaging (MRI) and computed tomography (CT). Quantitative MRI analysis of the pre- and postcontrast MRI scans facilitated assessment of relative arterial contributions...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29346713/spark-generated-microbubble-cell-sorter-for-microfluidic-flow-cytometry
#3
Jingjing Zhao, Zheng You
High-speed and accurate cell sorting is of great significance for cell analysis regarding both bioresearch and clinical application. Different from the jet-in-air sorting of commercial flow cytometers, sorting in fully enclosed and disposal microfluidic chips can avoid aerosols and crosscontamination, thus contributing to the improvement of biosafety and test accuracy. However, current microfluidic sorters usually require complicated structures, or otherwise cannot attain high throughput. In this article, a sorting mechanism for microfluidics is proposed for the first time based on the jet flow induced by the spark-generated cavitation microbubble that can be easily realized by a pair of electrodes...
January 18, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29346618/evidence-of-adaptive-evolution-and-relaxed-constraints-in-sex-biased-genes-of-south-american-and-west-indies-fruit-flies-diptera-tephritidae
#4
Carlos Congrains, Emeline B Campanini, Felipe R Torres, Víctor B Rezende, Aline M Nakamura, Janaína L de Oliveira, André L A Lima, Samira Chahad-Ehlers, Iderval S Sobrinho, Reinaldo A de Brito
Several studies have demonstrated that genes differentially expressed between sexes (sex-biased genes) tend to evolve faster than unbiased genes, particularly in males. The reason for this accelerated evolution is not clear, but several explanations have involved adaptive and non-adaptive mechanisms. Furthermore, the differences of sex-biased expression patterns of closely related species are also little explored out of Drosophila. To address the evolutionary processes involved with sex-biased expression in species with incipient differentiation, we analyzed male and female transcriptomes of Anastrepha fraterculus and A...
January 15, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29346611/combined-roles-of-atp-and-small-hairpin-rna-in-the-activation-of-rig-i-revealed-by-solution-based-analysis
#5
Neelam Shah, Simone A Beckham, Jacqueline A Wilce, Matthew C J Wilce
RIG-I (retinoic acid inducible gene-I) is a cytosolic innate immune protein that senses viral dsRNA with a 5'-triphosphate overhang. Upon interaction with dsRNA a de-repression of the RIG-I CARD domains takes place that ultimately leads to the production of type I interferons and pro-inflammatory cytokines. Here we investigate the RIG-I conformational rearrangement upon interaction with an activating 5'-triphosphate-10-base pair dsRNA hairpin loop (10bp) compared with a less active 5'-triphosphate-8-base pair dsRNA hairpin loop (8bp)...
January 13, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29346531/doppler-assessment-of-aortic-stenosis-a-25-operator-study-demonstrating-why-reading-the-peak-velocity-is-superior-to-velocity-time-integral
#6
Stefania Sacchi, Niti M Dhutia, Matthew J Shun-Shin, Massoud Zolgharni, Nilesh Sutaria, Darrel P Francis, Graham D Cole
Aims: Measurements with superior reproducibility are useful clinically and research purposes. Previous reproducibility studies of Doppler assessment of aortic stenosis (AS) have compared only a pair of observers and have not explored the mechanism by which disagreement between operators occurs. Using custom-designed software which stored operators' traces, we investigated the reproducibility of peak and velocity time integral (VTI) measurements across a much larger group of operators and explored the mechanisms by which disagreement arose...
January 15, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29346513/pancancer-analysis-identifies-prognostic-high-apobec1-expression-level-implicated-in-cancer-in-frame-insertions-and-deletions
#7
Ahmadreza Niavarani, Asieh Shahrabi Farahani, Maryam Sharafkhah, Minoo Rassoulzadegan
Genome insertions and deletions (indels) show tremendous functional impacts despite they are much less common than single nucleotide variants, which are at the center of studies assessing cancer mutational signatures. We studied 8,891 tumor samples of 32 types from The Cancer Genome Atlas in order to explore those genes which are potentially implicated in cancer indels. Survival analysis identified in-frame indels as the most important variants predicting adverse outcome. Transcriptome-wide association study identified 16 genes overexpressed in both tumor samples and tumor types with high number of in-frame indels, of whom four (APOBEC1, BCL2L15, FOXL1, and PDX1) were identified with gene products distributed within the nucleus...
January 13, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29346437/tissue-specific-transcriptome-analyses-provide-new-insights-into-gpcr-signalling-in-adult-schistosoma-mansoni
#8
REVIEW
Steffen Hahnel, Nic Wheeler, Zhigang Lu, Arporn Wangwiwatsin, Paul McVeigh, Aaron Maule, Matthew Berriman, Timothy Day, Paula Ribeiro, Christoph G Grevelding
Schistosomes are blood-dwelling trematodes with global impact on human and animal health. Because medical treatment is currently based on a single drug, praziquantel, there is urgent need for the development of alternative control strategies. The Schistosoma mansoni genome project provides a platform to study and connect the genetic repertoire of schistosomes to specific biological functions essential for successful parasitism. G protein-coupled receptors (GPCRs) form the largest superfamily of transmembrane receptors throughout the Eumetazoan phyla, including platyhelminths...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29346428/revisiting-facial-resemblance-in-couples
#9
Yetta Kwailing Wong, Wing Wah Wong, Kelvin F H Lui, Alan C-N Wong
It is widely believed that couples look alike. Consistently, previous research reported higher facial similarity for couples than non-couples, and that facial similarity predicts marital satisfaction. However, it is unclear if facial similarity in couples shown in previous studies was solely driven by extrinsic features like hairstyle, glasses, etc. Also unclear is what attributes are perceived as similar from the faces of a couple. In three experiments, we showed that faces were considered more similar in couples than non-couples even without extrinsic features...
2018: PloS One
https://www.readbyqxmd.com/read/29346419/saxs-analysis-of-a-soluble-cytosolic-ngbr-construct-including-extracellular-and-transmembrane-domains
#10
Joshua Holcomb, Maysaa Doughan, Nicholas Spellmon, Brianne Lewis, Emerson Perry, Yingxue Zhang, Lindsey Nico, Junmei Wan, Srinivas Chakravarthy, Weifeng Shang, Qing Miao, Timothy Stemmler, Zhe Yang
The Nogo-B receptor (NgBR) is involved in oncogenic Ras signaling through directly binding to farnesylated Ras. It recruits farnesylated Ras to the non-lipid-raft membrane for interaction with downstream effectors. However, the cytosolic domain of NgBR itself is only partially folded. The lack of several conserved secondary structural elements makes this domain unlikely to form a complete farnesyl binding pocket. We find that inclusion of the extracellular and transmembrane domains that contain additional conserved residues to the cytosolic region results in a well folded protein with a similar size and shape to the E...
2018: PloS One
https://www.readbyqxmd.com/read/29346411/evaluation-of-hirst-type-spore-traps-in-outdoor-aspergillaceae-monitoring-during-large-demolition-work-in-hospital
#11
Sophie Tiphaine Loeffert, Philippe Vanhems, Estelle Tissot, Cédric Dananché, Pierre Cassier, Thomas Bénet, Michel Perraud, Michel Thibaudon, Marie-Paule Gustin
Demolition can generate fungal spore suspensions in association with various adverse health effects, such as high risk of invasive aspergillosis in immunocompromised patients. One block of Edouard Herriot Hospital was entirely demolished. The aim of the present study was to evaluate Hirst-type spore traps utility in monitoring outdoor Aspergillaceae (Aspergillus spp. + Penicillium spp.) spores in part of Edouard Herriot Hospital (Lyon, France) undergoing major demolition. Three periods were scheduled in 2015: (A) Gutting of building and asbestos removal, (B) Demolition of floors, (C) Excavation and earthwork...
2018: PloS One
https://www.readbyqxmd.com/read/29346387/inferring-the-risk-factors-behind-the-geographical-spread-and-transmission-of-zika-in-the-americas
#12
Lauren M Gardner, András Bóta, Karthik Gangavarapu, Moritz U G Kraemer, Nathan D Grubaugh
BACKGROUND: An unprecedented Zika virus epidemic occurred in the Americas during 2015-2016. The size of the epidemic in conjunction with newly recognized health risks associated with the virus attracted significant attention across the research community. Our study complements several recent studies which have mapped epidemiological elements of Zika, by introducing a newly proposed methodology to simultaneously estimate the contribution of various risk factors for geographic spread resulting in local transmission and to compute the risk of spread (or re-introductions) between each pair of regions...
January 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346327/enhanced-isotopic-ratio-outlier-analysis-iroa-peak-detection-and-identification-with-ultra-high-resolution-gc-orbitrap-ms-potential-application-for-investigation-of-model-organism-metabolomes
#13
Yunping Qiu, Robyn D Moir, Ian M Willis, Suresh Seethapathy, Robert C Biniakewitz, Irwin J Kurland
Identifying non-annotated peaks may have a significant impact on the understanding of biological systems. In silico methodologies have focused on ESI LC/MS/MS for identifying non-annotated MS peaks. In this study, we employed in silico methodology to develop an Isotopic Ratio Outlier Analysis (IROA) workflow using enhanced mass spectrometric data acquired with the ultra-high resolution GC-Orbitrap/MS to determine the identity of non-annotated metabolites. The higher resolution of the GC-Orbitrap/MS, together with its wide dynamic range, resulted in more IROA peak pairs detected, and increased reliability of chemical formulae generation (CFG)...
January 18, 2018: Metabolites
https://www.readbyqxmd.com/read/29346086/the-dynamics-of-a-serum-steroid-profile-after-stimulation-with-intravenous-acth
#14
Johanna M Lindner, Anna Catharina Suhr, Stefanie H Grimm, Patrick Möhnle, Michael Vogeser, Josef Briegel
BACKGROUND: Stimulation with intravenous adrenocorticotropic hormone (ACTH) is a widely used diagnostic procedure to characterize the adrenocortical function. Currently, the response of serum cortisol, mainly quantified by immunoassays, is the only established read-out of this test. By using liquid chromatography coupled with mass spectrometry (LC-MS/MS) simultaneous determination of several steroids that respond to ACTH stimulation is now possible. The aim of this study was to further characterize the typical effect of exogenous ACTH (250 mg) on a LC-MS/MS-serum steroid profile...
December 26, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29345924/domain-based-local-pair-natural-orbital-version-of-mukherjee-s-state-specific-coupled-cluster-method
#15
Jiri Brabec, Jakub Lang, Masaaki Saitow, Jiri Pittner, Frank Neese, Ondrej Demel
This article reports development of a local variant of Mukherjee's state specific multireference coupled cluster method based on the domain-based pair natural orbital approach (DLPNO-MkCC). The current implementation is restricted to connected single and double excitations and model space with up to biexcited references. The performance of the DLPNO-MkCCSD was tested on calculations of tetramethyleneethane. The results show that above 99.9% of correlation energy was recovered, with respect to the conventional MkCC method...
January 18, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29345917/anisotropic-assembly-of-ag52-and-ag76-nanoclusters
#16
Jia-Wei Liu, Lei Feng, Haifeng Su, Zhi Wang, Quan-Qin Zhao, Xingpo Wang, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
Although there has been an upsurge of interest in anisotropic assembly of inorganic nanoparticles, atomically precise self-assembly of anisotropic (nonspherical) high-nuclearity metal clusters is extremely rare. Herein, we presented two novel silver nanoclusters, Ag52 (SD/Ag23) and Ag76 (SD/Ag24), which are interiorly templated by five MoO42- and a pair of Mo6O228- anions, respectively, and co-protected by bridging RSH and terminal diphosphine ligands exteriorly. Regiospe-cific distribution diphosphine ligands on the surface and the arrangement of multiple molybdate templates within the nanoclusters synergetically tailor their shapes to anisotropic oblate spheroid and elongated rod, respectively, as opposed to isotropic nanospheres...
January 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29345700/abnormal-separation-of-the-silicon-oxygen-bond-in-the-liquid-layering-transition-of-silicon-dioxide-in-a-nanoslit
#17
Zhichao Wang, Tao Li, Yunrui Duan, Weikang Wu, Zhenyang Zhao, Yao Liu, Hui Li
We investigated the unusual layering transition (LT) in quasi-2D liquid silicon dioxide (SiO2) confined in a nanoslit. Our results indicate that the slit size and pressure induce the abnormal LT in liquid SiO2, accompanied by a rapid change in the density, diffusion coefficient, pair correlation function and average potential energy. The silicon and oxygen atoms are almost completely separated under the extremely strong confinement effect, which is the characteristic feature of the LT. The negative slope of the LT lines in the phase diagram at different pressures suggests that a confinement-induced LT occurs at high pressure and a pressure-induced LT occurs at low pressure...
January 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29345483/editorial-journal-article-reporting-standards
#18
Anne E Kazak
In this editorial, the author notes that this issue of American Psychologist features a pair of important articles related to newly updated standards for reporting research in psychology in scientific journals, covering both quantitative (Appelbaum et al., 2018) and qualitative (Levitt et al., 2018) research. The increasing breadth and complexity of research, and the importance of communicating it effectively, requires user-friendly resources that can be applied widely to scientific studies. These two articles are intended to serve that purpose, and to encourage thoroughness and accuracy in research reporting, for psychologists and other scientists in broader academic communities...
January 2018: American Psychologist
https://www.readbyqxmd.com/read/29345463/-%C3%A2-sativamides-a-and-b-two-pairs-of-racemic-nor-lignanamide-enantiomers-from-the-fruits-of-cannabis-sativa-hemp-seed
#19
Guo-Yuan Zhu, Ji Yang, Xiao-Jun Yao, Xing Yang, Jing Fu, Xin Liu, Li-Ping Bai, Liang Liu, Zhi-Hong Jiang
(±)-Sativamides A (1) and B (2), two pairs of nor-lignanamide enantiomers featuring a unique benzo-angular triquinane skeleton, were isolated from the fruits of Cannabis sativa (hemp seed). Their structures were elucidated by detailed spectroscopic analysis and ECD calculations. The resolution of (+)- and (-)-sativamides A and B were achieved by chiral HPLC. Pretreatment of neuroblastoma cells with 1 and 2 significantly reduced the endoplasmic reticulum (ER) stress-induced cytotoxicity.
January 18, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29345270/energetics-and-dynamics-of-the-non-natural-fluorescent-4ap-dap-base-pair
#20
Mohit Chawla, Ida Autiero, Romina Oliva, Luigi Cavallo
The fluorescent non-natural 4-aminophthalimide (4AP) base, when paired to the complementary 2,4-diaminopyrimidine (DAP) nucleobase, is accommodated in a B-DNA duplex being efficiently recognized and incorporated by DNA polymerases. To complement the experimental studies and rationalize the impact of the above non-natural bases on the structure, stability and dynamics of nucleic acid structures, we performed quantum mechanics (QM) calculations along with classical molecular dynamics (MD) simulations. QM calculations were initially focused on the geometry and energetics of the 4AP:DAP non-natural pair and of H-bonded base pairs between 4AP and all the natural bases in their classical Watson-Crick geometries...
January 18, 2018: Physical Chemistry Chemical Physics: PCCP
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