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High fructose diet

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https://www.readbyqxmd.com/read/29046729/long-term-feeding-of-high-fat-plus-high-fructose-diet-induces-isolated-impaired-glucose-tolerance-and-skeletal-muscle-insulin-resistance-in-miniature-pigs
#1
Meng-Chieh Hsu, Mu-En Wang, Yi-Fan Jiang, Hung-Chang Liu, Yi-Chen Chen, Chih-Hsien Chiu
BACKGROUND: During the prediabetic development, the changes in β-cell function and tissue-specific insulin resistance have been described. However, there are conflicting views in insulin secretory capacity between early clinical observation and recent proposed mathematical model. On the basis of digestive and metabolic similarities with humans, swine have great potential as an animal model to investigate the progressive mechanisms of prediabetes. The aim of this study was to investigate the insulin secretory response and tissue-specific insulin resistance in a dietary-induced prediabetic porcine model...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29034600/no-adverse-programming-by-post-weaning-dietary-fructose-of-body-weight-adiposity-glucose-tolerance-or-metabolic-flexibility
#2
Lianne M S Bouwman, José M S Fernández-Calleja, Hans J M Swarts, Inge van der Stelt, Annemarie Oosting, Jaap Keijer, Evert M van Schothorst
SCOPE: Metabolic programming can occur not only in the perinatal period, but also post-weaning. This study aimed to assess whether fructose, in comparison to glucose, in the post-weaning diet programs body weight, adiposity, glucose tolerance, metabolic flexibility and health at adult age. METHODS AND RESULTS: Three-week-old male and female C57BL6/JRccHsd mice were given an intervention diet with 32 en% glucose or fructose for only three weeks. Next, all animals were switched to the same 40 en% high fat diet for nine weeks...
October 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29025734/dietary-copper-fructose-interactions-alter-gut-microbial-activity-in-male-rats
#3
Ming Song, Xiaohong Li, Xiang Zhang, Hongxue Shi, Miriam B Vos, Xiaoli Wei, Yuhua Wang, Hong Gao, Eric C Rouchka, Xinmin Yin, Zhanxiang Zhou, Russell A Prough, Matthew C Cave, Craig J McClain
Dietary copper-fructose interactions contribute to the development of nonalcoholic fatty liver disease (NAFLD). Gut microbiota play critical roles in the pathogenesis of NAFLD. The aim of this study was to determine the effect of different dietary doses of copper and their interactions with high fructose on gut microbiome. Male weanling Sprague-Dawley rats were fed diets with adequate copper (6 ppm, CuA), marginal copper (1.5 ppm, CuM) (low-copper) or supplemented copper (20 ppm, CuS) (high-copper) for 4 weeks...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29023819/non-alcoholic-fatty-liver-disease-impairs-expression-of-the-type-ii-inositol-1-4-5-trisphosphate-receptor
#4
Tanaporn Khamphaya, Natsasi Chukijrungroat, Vitoon Saengsirisuwan, Kisha A Mitchell-Richards, Marie E Robert, Albert Mennone, Michael H Nathanson, Jittima Weerachayaphorn
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It may result in several types of liver problems including impaired liver regeneration, but the mechanism for this is unknown. Because liver regeneration depends on calcium signaling, we examined the effects of NAFLD on expression of the type II inositol 1,4,5-trisphosphate receptor (ITPR2), the principle calcium release channel in hepatocytes. ITPR2 promoter activity was measured in Huh7 and HepG2 cells. ITPR2 and c-Jun protein levels were evaluated in Huh7 cells, in liver tissue from a rat model of NAFLD and in liver biopsy specimens of patients with simple steatosis and non-alcoholic steatohepatitis (NASH)...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28974035/nutritional-and-health-related-effects-of-a-diet-containing-apple-seed-meal-in-rats-the-case-of-amygdalin
#5
Paulina M Opyd, Adam Jurgoński, Jerzy Juśkiewicz, Joanna Milala, Zenon Zduńczyk, Bogusław Król
Apple pomace includes seeds that are rich in protein, fiber, and oil, which can be extracted from them. However, they can also contain a significant amount of toxigenic amygdalin. We hypothesized that amygdalin is a compound that significantly reduces the nutritional and health quality of defatted apple seeds. An experiment was conducted on rats that were distributed into three groups and fed with high-fructose diets. In the control (C) and amygdalin (AMG) groups, cellulose and casein were the source of dietary fiber and protein, respectively; in the apple seed meal (ASM) group, dietary fiber and protein originated from the endosperm of apple seeds, which were previously defatted and ground...
October 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28972878/role-of-nutrition-gene-polymorphism-and-gut-microbiota-in-non-alcoholic-fatty-liver-disease
#6
Lingbo Kong, Yu Lu, Siyu Zhang, Yuemin Nan, Liang Qiao
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. The nutrients play important roles in the development and progression of NAFLD. High-calorie diet, especially the diet rich in saturated fatty acids and cholesterol, as well as sugary drinks with high fructose content, induces hepatic steatosis and triggers progression of steatohepatitis, fibrosis, and even hepatocellular carcinoma. Disordered micronutrient status and gut microbiota are also involved in the pathogenesis of NAFLD...
September 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28972610/fat-1-mice-prevent-high-fat-plus-high-sugar-diet-induced-non-alcoholic-fatty-liver-disease
#7
Xiao-Fei Guo, Jin-Long Gao, Jiao-Mei Li, Duo Li
High-fat and high-sugar (HFS) diets have been suggested to play a causal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate whether fat-1 transgenic mice with a higher tissue content of n-3 polyunsaturated fatty acids (PUFAs) could prevent HFS diet-induced NAFLD, compared with wild-type mice. The fat-1 and wild-type littermates had free access to a 15% fructose solution plus high-fat diet, a 15% glucose solution plus high-fat diet, or a 15% sucrose solution plus high-fat diet, respectively...
October 3, 2017: Food & Function
https://www.readbyqxmd.com/read/28972537/divergent-effects-of-glucose-and-fructose-on-hepatic-lipogenesis-and-insulin-signaling
#8
Samir Softic, Manoj K Gupta, Guo-Xiao Wang, Shiho Fujisaka, Brian T O'Neill, Tata Nageswara Rao, Jennifer Willoughby, Carole Harbison, Kevin Fitzgerald, Olga Ilkayeva, Christopher B Newgard, David E Cohen, C Ronald Kahn
Overconsumption of high-fat diet (HFD) and sugar-sweetened beverages are risk factors for developing obesity, insulin resistance, and fatty liver disease. Here we have dissected mechanisms underlying this association using mice fed either chow or HFD with or without fructose- or glucose-supplemented water. In chow-fed mice, there was no major physiological difference between fructose and glucose supplementation. On the other hand, mice on HFD supplemented with fructose developed more pronounced obesity, glucose intolerance, and hepatomegaly as compared to glucose-supplemented HFD mice, despite similar caloric intake...
October 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28970966/increased-utilization-of-fructose-has-a-positive-effect-on-the-development-of-breast-cancer
#9
Xiajing Fan, Hongru Liu, Miao Liu, Yuanyuan Wang, Li Qiu, Yanfen Cui
Rapid proliferation and Warburg effect make cancer cells consume plenty of glucose, which induces a low glucose micro-environment within the tumor. Up to date, how cancer cells keep proliferating in the condition of glucose insufficiency still remains to be explored. Recent studies have revealed a close correlation between excessive fructose consumption and breast cancer genesis and progression, but there is no convincing evidence showing that fructose could directly promote breast cancer development. Herein, we found that fructose, not amino acids, could functionally replace glucose to support proliferation of breast cancer cells...
2017: PeerJ
https://www.readbyqxmd.com/read/28970836/fructose-a-dietary-sugar-in-crosstalk-with-microbiota-contributing-to-the-development-and-progression-of-non-alcoholic-liver-disease
#10
REVIEW
Jessica Lambertz, Sabine Weiskirchen, Silvano Landert, Ralf Weiskirchen
Fructose is one of the key dietary catalysts in the development of non-alcoholic fatty liver disease (NAFLD). NAFLD comprises a complex disease spectrum, including steatosis (fatty liver), non-alcoholic steatohepatitis, hepatocyte injury, inflammation, and fibrosis. It is also the hepatic manifestation of the metabolic syndrome, which covers abdominal obesity, insulin resistance, dyslipidemia, glucose intolerance, or type 2 diabetes mellitus. Commensal bacteria modulate the host immune system, protect against exogenous pathogens, and are gatekeepers in intestinal barrier function and maturation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28967023/grape-pomace-reduced-reperfusion-arrhythmias-in-rats-with-a-high-fat-fructose-diet
#11
Diahann J Perdicaro, Cecilia Rodriguez Lanzi, Ariel R Fontana, Andrea Antoniolli, Patricia Piccoli, Roberto M Miatello, Emiliano R Diez, Marcela A Vazquez Prieto
Metabolic syndrome (MetS) is a risk factor for sudden cardiac death in humans, but animal models are needed for the study of this association. Grape pomace (GP), obtained from the winemaking process, contains phenolic compounds with potential cardioprotective effects. The aim of this study was to evaluate if a high-fat-fructose (HFF) diet facilitates the occurrence of arrhythmias during the reperfusion, and if a GP supplementation could counteract these effects. Wistar rats were fed with control (Ctrl), HFF diet and HFF plus GP (1 g kg(-1) day(-1)) for six weeks...
October 2, 2017: Food & Function
https://www.readbyqxmd.com/read/28961924/glycerol-and-testicular-activity-the-good-the-bad-and-the-ugly
#12
Luís Crisóstomo, Marco G Alves, Giuseppe Calamita, Mário Sousa, Pedro F Oliveira
Over the past decades, there have been several studies suggesting that semen quality is declining. Interestingly, these observations are paired with a significant increase in the number of individuals diagnosed with metabolic diseases, including obesity and diabetes mellitus. Hence, it is tempting to hypothesize that obesity and its associated comorbidities and risk factors (such as a hypercaloric diets) impair the homeostasis of the male reproductive health, with a possible direct effect on the testes. The blood and interstitial fluids of obese individuals usually have increased levels of glycerol, notably due to triglyceride and phospholipid catabolism and high fructose intake...
September 7, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28960302/nutritional-and-phytochemical-composition-of-vaccinium-padifolium-sm-wild-berries-and-radical-scavenging-activity
#13
Maria J Carvalho, Carla S Gouveia, Ana C Vieira, Ana C Pereira, Miguel  Carvalho, José C Marques
Blueberries have a well-deserved reputation as a potential functional food, supported by studies which have identified and quantified various nutrients and bioactive phytochemicals with known benefits for human diet and health. Wild blueberries have attracted particular attention due to the levels and concentrations of those phytonutrients. This study aims to evaluate for the first time the chemical composition of Madeira Island's endemic Vaccinium padifolium Sm wild berry. Results show that this fruit contains high values of total soluble phenolic content (around 4 g GAE kg(-1) FW), as well as significant values of total monomeric anthocyanin content (around 3 g eq...
September 29, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28946183/cardioprotective-effect-of-phyllanthus-amarus-against-high-fructose-diet-induced-myocardial-and-aortic-stress-in-rat-model
#14
Mallaiah Putakala, Sudhakara Gujjala, Srinivasulu Nukala, Sasi Bhusana Rao Bongu, Nagaraju Chintakunta, Saralakumari Desireddy
Increased number of population with heart stroke/attack is attributed to sedentary lifestyle and consumption of high-sugar diets, especially fructose. The objective of this study is to investigate the cardio-protective activity of aqueous extract of Phyllanthus amarus (PAAE) against high-fructose (HF) diet induced cardiac damage in Wistar rats. Male Wistar rats were randomly assigned into five groups of six animals each: Control (C), Control treated with PAAE (C+PAAE), High fructose diet fed (F), High fructose diet fed treated with PAAE (F+PAAE) and High fructose diet fed treated with Pioglitazone (F+Pio)...
September 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28944721/early-life-sugar-consumption-has-long-term-negative-effects-on-memory-function-in-male-rats
#15
Emily E Noble, Ted M Hsu, Joanna Liang, Scott E Kanoski
OBJECTIVES: Added dietary sugars contribute substantially to the diet of children and adolescents in the USA, and recent evidence suggests that consuming sugar-sweetened beverages (SSBs) during early life has deleterious effects on hippocampal-dependent memory function. Here, we test whether the effects of early-life sugar consumption on hippocampal function persist into adulthood when access to sugar is restricted to the juvenile/adolescent phase of development. METHODS: Male rats were given ad libitum access to an 11% weight-by-volume sugar solution (made with high fructose corn syrup-55) throughout the adolescent phase of development (post-natal day (PN) 26-56)...
September 25, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28939830/lack-of-nlrp3-inflammasome-leads-to-gut-liver-axis-derangement-gut-dysbiosis-and-a-worsened-phenotype-in-a-mouse-model-of-nafld
#16
Pierantonelli Irene, Rychlicki Chiara, Agostinelli Laura, Giordano Debora Maria, Gaggini Melania, Fraumene Cristina, Saponaro Chiara, Manghina Valeria, Sartini Loris, Mingarelli Eleonora, Pinto Claudio, Buzzigoli Emma, Trozzi Luciano, Giordano Antonio, Marzioni Marco, De Minicis Samuele, Uzzau Sergio, Cinti Saverio, Amalia Gastalderi, Svegliati-Baroni Gianluca
Non-Alcoholic Fatty Liver Disease (NAFLD) represents the most common form of chronic liver injury and can progress to cirrhosis and hepatocellular carcinoma. A "multi-hit" theory, involving high fat diet and signals from the gut-liver axis, has been hypothesized. The role of the NLRP3-inflammasome, which senses dangerous signals, is controversial. Nlrp3(-/-) and wild-type mice were fed a Western-lifestyle diet with fructose in drinking water (HFHC) or a chow diet. Nlrp3(-/-)-HFHC showed higher hepatic expression of PPAR γ2 (that regulates lipid uptake and storage) and triglyceride content, histological score of liver injury and greater adipose tissue inflammation...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28938434/fgf21-is-an-insulin-dependent-postprandial-hormone-in-adult-humans
#17
Ricardo J Samms, Jo E Lewis, Luke Norton, Francis B Stephens, Christopher J Gaffney, Tony Butterfield, Dennis Smith, Christine Cheng, James W Perfield, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
Context: Fibroblast growth factor 21 (FGF21) secretion has been shown to respond directly to carbohydrate consumption, with glucose, fructose and sucrose all reported to increase plasma levels of FGF21 in rodents and humans. However, carbohydrate consumption also results in secretion of insulin. Objective: The aim of this study was to examine the combined and independent effects of hyperglycemia and hyperinsulinemia on total and bioactive FGF21 in the postprandial period in humans, and determine whether this effect is attenuated in conditions of altered insulin secretion and action...
August 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28934253/xuezhikang-contributes-to-greater-triglyceride-reduction-than-simvastatin-in-hypertriglyceridemia-rats-by-up-regulating-apolipoprotein-a5-via-the-ppar%C3%AE-signaling-pathway
#18
Shui-Ping Zhao, Rong Li, Wen Dai, Bi-Lian Yu, Lu-Zhu Chen, Xian-Sheng Huang
Xuezhikang (XZK), an extract of Chinese red yeast rice, is recommended as an optimal choice for patients with coronary heart disease (CHD) with markedly elevated triglyceride (TG) levels. This study was designed to compare the hypotriglyceridemic effects between XZK and simvastatin. The role of apolipoprotein A5 (apoA5), a key regulator of TG metabolism and a target gene of peroxisome proliferator-activated receptor α (PPARα), was to be identified in XZK-related hypotriglyceridemic actions. For these goals, hypertriglyceridemia of rats was induced by a high-fructose diet...
2017: PloS One
https://www.readbyqxmd.com/read/28916335/troxerutin-abrogates-mitochondrial-oxidative-stress-and-myocardial-apoptosis-in-mice-fed-calorie-rich-diet
#19
Rajagopalan Geetha, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha
Mitochondrial oxidative stress plays a major role in the pathogenesis of myocardial apoptosis in metabolic syndrome (MS) patients. In this study, we investigated the effect of troxerutin (TX), an antioxidant on mitochondrial oxidative stress and apoptotic markers in heart of mice fed fat and fructose-rich diet. Adult male Mus musculus mice were fed either control diet or high fat, high fructose diet (HFFD) for 60 days to induce MS. Mice from each dietary group were divided into two on the 16th day and were either treated or untreated with TX (150 mg/kg bw, p...
September 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28911649/long-chain-bases-from-sea-cucumber-mitigate-endoplasmic-reticulum-stress-and-inflammation-in-obesity-mice
#20
Shiwei Hu, Jinhui Wang, Jingfeng Wang, Changhu Xue, Yuming Wang
Endoplasmic reticulum (ER) stress and inflammation can induce hyperglycemia. Long-chain bases (LCBs) from sea cucumber exhibit antihyperglycemic activities. However, their effects on ER stress and inflammation are unknown. We investigated the effects of LCBs on ER stress and inflammatory response in high-fat, fructose diet-induced obesity mice. Reactive oxygen species and free fatty acids were measured. Inflammatory cytokines in serum and their mRNA expressions in epididymal adipose tissues were investigated...
July 2017: Journal of Food and Drug Analysis
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