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High fructose diet

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https://www.readbyqxmd.com/read/27911087/%C3%AE-amyrin-attenuates-high-fructose-diet-induced-metabolic-syndrome-in-rats
#1
Pankaj Prabhakar, K H Reeta, Subir Kumar Maulik, Amit Kumar Dinda, Yogendra Kumar Gupta
This study investigated the effect of α-amyrin (a pentacyclic triterpene) on high-fructose diet (HFD)-induced metabolic syndrome in rats. Male Wistar rats were randomly distributed into different groups. The control group was fed normal rat chow diet. The HFD group was fed HFD (60%; w/w) for 42 days. Pioglitazone (10 mg/kg, orally, once daily) was used as a standard drug. α-Amyrin was administered in 3 doses (50, 100, and 200 mg/kg, orally, once daily along with HFD). Plasma glucose, total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-C) were estimated...
September 2, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27910784/hepatoprotective-effect-of-tricholoma-giganteum-agaricomycetes-in-a-nonalcoholic-fatty-liver-disease-rat-model
#2
Ramar Govindaraj, Michael Gabriel Paulraj, Erenius Toppo, Perumal Pandikumar, Savarimuthu Ignacimuthu, Naif Abdhullah Al-Dhabi
Different concentrations of standardized ethanolic extract from the basidiocarps of Tricholoma giganteum Massee (TgEtOH) were screened for hepatoprotective effects in an animal model of rats with nonalcoholic fatty liver disease (NAFLD) fed a high-fat and high-fructose diet. After 4 weeks of treatment with TgEtOH, the relative liver weights, serum lipid concentrations, and biochemical profiles were found to be normal in treated animals compared with those given a standard drug. The macroscopic and histopathological studies clearly indicated that 200 mg/kg of ethanolic extract was effective in ameliorating the abnormalities of NAFLD...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27909228/divergent-outcomes-of-fructose-consumption-on-exercise-capacity-of-rats-friend-or-foe
#3
Angela Sun, An Huang, Elizabeth Kertowidjojo, Su Song, Thomas H Hintze, Dong Sun
To test the hypothesis that high fructose (HF) consumption divergently affects exercise capability, as a function of feeding duration, rats were fed a normal (as control) or a normal caloric diet with HF for 3, 6, 10 and 30 days respectively, and run on a treadmill. Results show that running distance and work were significantly increased, associated with greater exercise oxygen consumption in rats fed HF for 3 (HF-3D) and 6 days, but were decreased in rats fed HF for 30 days (HF-30D) compared to their respective control rats...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27904687/high-fructose-causes-cardiac-hypertrophy-via-mitochondrial-signaling-pathway
#4
Yan-Bo Zhang, Yan-Hai Meng, Shuo Chang, Rong-Yuan Zhang, Chen Shi
High fructose diet can cause cardiac hypertrophy and oxidative stress is a key mediator for myocardial hypertrophy. Disruption of cystic fibrosis transmembrane conductance regulator (CFTR) leads to oxidative stress. This study aims to reveal mitochondrial oxidative stress-related signaling pathway in high fructose-induced cardiac hypertrophy. Mice were fed high fructose to develop cardiac hypertrophy. Fructose and H2O2 were used to induce cardiomyocyte hypertrophy in vitro. Mitochondria-targeted antioxidant SkQ1 was applied to investigate the possible role of mitochondrial reactive oxygen species (ROS)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27901349/curcumin-improves-the-metabolic-syndrome-in-high-fructose-diet-fed-rats-role-of-tnf-%C3%AE-nf-%C3%AE%C2%BAb-and-oxidative-stress
#5
Mohamed Elsayed Kelany, Tahir M Hakami, Adel H Omar
This study aimed to investigate effects of curcumin on high fructose diet (HFD)-induced metabolic syndrome (MetS) in rats and the possible mechanisms involved. MetS was induced in male albino rats (n = 20), over 8 weeks, by 65% HFD. For 8-week experiment period, rats were assigned to 2 equal groups: curcumin-treated rats received curcumin (200 mg/kg, p.o, once daily) along with HFD, and untreated rats were fed with HFD only. We evaluated body mass (BM), systolic blood pressure (SBP), homeostasis model assessment of insulin resistance (HOMA-IR), and serum levels of glucose, insulin, leptin, total cholesterol (TC), triglycerides (TGs), uric acid, malondialdehyde (MDA; lipid peroxidation product), and tumor necrosis factor-α (TNF-α; inflammatory cytokine), and serum catalase (endogenous antioxidant) activity and immunohistochemical expression of nuclear factor κB (NF-κB; inflammation-related transcription factor) in hepatocytes...
August 17, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27895989/diet-induced-obesity-skin-changes-monitored-by-in-vivo-shg-and-ex-vivo-cars-microscopy
#6
Dóra Haluszka, Kende Lőrincz, Norbert Kiss, Róbert Szipőcs, Enikő Kuroli, Nóra Gyöngyösi, Norbert M Wikonkál
Obesity related metabolic syndrome and type 2 diabetes have severe consequences on our skin. Latest developments in nonlinear microscopy allow the use of noninvasive, label free imaging methods, such as second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS), for early diagnosis of metabolic syndrome-related skin complications by 3D imaging of the skin and the connective tissue. Our aim was to study effects of various types of diet-induced obesity in mice using these methods. We examined mice on different diets for 32 weeks...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27895389/comparisons-of-dietary-intake-in-japanese-with-non-alcoholic-fatty-liver-disease-and-type-2-diabetes-mellitus
#7
Yukiko Kobayashi, Hina Tatsumi, Mikako Hattori, Hiroki Sugiyama, Sayori Wada, Masashi Kuwahata, Saiyu Tanaka, Kazuyuki Kanemasa, Yoshio Sumida, Yuji Naito, Michiaki Fukui, Yasuhiro Kido
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that involves a complex interaction between genetics, diet, and lifestyle, all of which combine to form the NAFLD phenotype. In Japan, medical nutrition therapy for NAFLD has not yet been established, so NAFLD patients are instructed in the dietary modifications used for type 2 diabetes mellitus (T2DM). Because points of difference may exist in the effects of dietary choices on NAFLD and T2DM, the present study aimed to compare and assess the dietary intake of Japanese individuals with NAFLD and T2DM...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27894971/aqueous-seed-extract-of-hunteria-umbellata-k-schum-hallier-f-apocynaceae-palliates-hyperglycemia-insulin-resistance-dyslipidemia-inflammation-and-oxidative-stress-in-high-fructose-diet-induced-metabolic-syndrome-in-rats
#8
T O Ajiboye, A A Hussaini, B Y Nafiu, O B Ibitoye
ETHNOPHARMACOLOGICAL RELEVANCE: Hunteria umbellata is used in the management and treatment of diabetes and obesity in Nigeria. This study evaluates the effect of aqueous seed extract of Hunteria umbellata on insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome. MATERIALS AND METHODS: Rats were randomized into seven groups (A-G). Control (group A) and group C rats received control diet for nine weeks while rats in groups B, D - G were placed on high-fructose diet for 9 weeks...
November 25, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27891351/evaluation-of-effect-of-nishamalaki-on-stz-and-hfhf-diet-induced-diabetic-neuropathy-in-wistar-rats
#9
Jayshree Shriram Dawane, Vijaya Anil Pandit, Madhura Shirish Kumar Bhosale, Pallawi Shashank Khatavkar
INTRODUCTION: Diabetic neuropathy is one of the most common complications affecting 50% of diabetic patients. Neuropathic pain is the most difficult types of pain to treat. There is no specific treatment for neuropathy. Nishamalaki (NA), combination of Curcuma longa and Emblica officinalis used to treat Diabetes Mellitus (DM). So, efforts were made to test whether NA is useful in prevention of diabetic neuropathy. AIM: To evaluate the effect of NA on diabetic neuropathy in type 2 diabetic wistar rats...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27882410/a-review-of-recent-evidence-relating-to-sugars-insulin-resistance-and-diabetes
#10
REVIEW
I A Macdonald
The potential impact on health of diets rich in free sugars, and particularly fructose, is of major concern. The focus of this review is the impact of these sugars on insulin resistance and obesity, and the associated risk of developing type 2 diabetes. Much of the concern is focussed on specific metabolic effects of fructose, which are argued to lead to increased fat deposition in the liver and skeletal muscle with subsequent insulin resistance and increased risk of diabetes. However, much of the evidence underpinning these arguments is based on animal studies involving very large intakes of the free sugars...
November 23, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27874078/glutamate-dehydrogenase-activator-bch-stimulating-reductive-amination-prevents-high-fat-high-fructose-diet-induced-steatohepatitis-and-hyperglycemia-in-c57bl-6j-mice
#11
Seung Jin Han, Sung-E Choi, Sang-A Yi, Jong Gab Jung, Ik-Rak Jung, Maureen Shin, Seok Kang, Hyunhee Oh, Hae Jin Kim, Dae Jung Kim, Ji Eun Kwon, Cheol Soo Choi, Kwan Woo Lee, Yup Kang
Individuals with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) induced by high calorie western diet are characterized by enhanced lipogenesis and gluconeogenesis in the liver. Stimulation of reductive amination may shift tricarboxylic acid cycle metabolism for lipogenesis and gluconeogenesis toward glutamate synthesis with increase of NAD+/NADH ratio and thus, ameliorate high calorie diet-induced fatty liver and hyperglycemia. Stimulation of reductive amination through glutamate dehydrogenase (GDH) activator 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) reduced both de novo lipogenesis and gluconeogenesis but increased the activities of sirtuins and AMP-activated kinase in primary hepatocytes...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27863346/a-diet-induced-sprague-dawley-rat-model-of-nonalcoholic-steatohepatitis-related-cirrhosis
#12
Mayuko Ichimura, Miki Masuzumi, Miku Kawase, Mika Sakaki, Shizuka Tamaru, Yasuo Nagata, Kazunari Tanaka, Kazuhito Suruga, Koichi Tsuneyama, Satoru Matsuda, Katsuhisa Omagari
Certain modified diets containing saturated fatty acids, cholesterol or fructose lead to the development of nonalcoholic steatohepatitis (NASH)-related fibrosis in rodents; however, progression to cirrhosis is rare. Experimental liver cirrhosis models have relied on genetic manipulation or administration of hepatotoxins. This study aimed to establish a reliable dietary model of NASH-related cirrhosis in a relatively short period. Male Sprague-Dawley rats (9 weeks of age) were randomly assigned to normal, high-fat (HF), or two types (1...
October 24, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27862118/prevention-of-hepatic-fibrosis-with-liver-microsomal-triglyceride-transfer-protein-deletion-in-liver-fatty-acid-binding-protein-null-mice
#13
Elizabeth P Newberry, Yan Xie, Susan M Kennedy, Mark J Graham, Rosanne M Crooke, Hui Jiang, Anping Chen, Daniel S Ory, Nicholas O Davidson
: Blocking hepatic very low density lipoprotein (VLDL) secretion via genetic or pharmacologic inhibition of microsomal triglyceride (TG) transfer protein (Mttp) causes hepatic steatosis, yet the risks for developing hepatic fibrosis are poorly understood. Here we report that liver-specific Mttp knockout mice (Mttp-LKO) exhibit both steatosis and fibrosis, which is exacerbated by a high trans fat, fructose diet. When crossed into germline Liver fatty acid binding protein null mice (Mttp-LKO, L-Fabp (-/-) , ie DKO mice) hepatic steatosis was greatly diminished and fibrosis prevented, on both low and high fat diets...
November 14, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27860326/docosapentaenoic-acid-and-docosahexaenoic-acid-positively-associate-with-insulin-sensitivity-in-rats-fed-high-fat-and-high-fructose-diets
#14
Jiung-Pang Huang, Mei-Ling Cheng, Cheng-Yu Hung, Chao-Hung Wang, Po-Shiuan Hsieh, Ming-Shi Shiao, Jan-Kan Chen, Dai-Er Li, Li-Man Hung
BACKGROUND: We compared the insulin resistance and metabolic alterations by using a global lipidomic approach. METHODS: Rats were fed with high-fat-diet (HFD) and high-fructose-diet (HFr) for 12 weeks to induced insulin resistance syndrome. RESULTS: Rats on both diets developed of insulin resistance syndrome, characterized by hypertension, hyperlipidemia, hyperinsulinemia, impaired fasting glucose, and insulin resistance. Compared with HFr rats, nonesterified-fatty-acid was lower, and body weight and plasma insulin level were markedly higher in the HFD animals...
November 8, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27858215/effects-of-amino-acid-supplementations-on-metabolic-and-physiological-parameters-in-atlantic-cod-gadus-morhua-under-stress
#15
Marcelino Herrera, María Antonia Herves, Inmaculada Giráldez, Kristin Skar, Hanne Mogren, Atle Mortensen, Velmurugu Puvanendran
The effects of tryptophan (Trp) and phenylalanine (Phe) diet supplementation on the stress and metabolism of the Atlantic cod have been studied. Fish were fed diet supplemented with Trp or Phe or control diet for 1 week. At the end of the feeding trial, fish were subjected to air exposure or heat shock. Following samples of blood, liver and muscle were taken from the fish and were analyzed for stress and metabolic indicators. After an air exposure, plasma cortisol levels in fish fed with Trp and Phe diets were lower compared to the fish fed the control diet...
November 17, 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/27832314/diets-high-in-fat-or-fructose-differentially-modulate-bone-health-and-lipid-metabolism
#16
Aditi Jatkar, Irwin J Kurland, Stefan Judex
Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we contrasted the effects of a high fat (HF) versus fructose-enriched carbohydrate (CH) versus regular chow (SC) diet on bone morphology, fat content and metabolic balance in BALB/cByJ mice over a 15-week period. For 13 weeks, there were no differences in body mass between groups with small differences in the last 2 weeks. Even without the potentially confounding factor of altered body mass and levels of load bearing, HF consumption was detrimental to bone in the distal femur with lower trabecular bone volume fraction and thinner cortices than controls...
November 10, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27818793/transient-decrease-in-circulatory-testosterone-and-homocysteine-precedes-the-development-of-metabolic-syndrome-features-in-fructose-fed-sprague-dawley-rats
#17
Anil Sakamuri, Sujatha Pitla, Uday Kumar Putcha, Sugeedha Jayapal, Sailaja Pothana, Sai Santosh Vadakattu, Nagabhushan Reddy Konapalli, Siva Sankara Vara Prasad Sakamuri, Ahamed Ibrahim
Background. Increased fructose consumption is linked to the development of metabolic syndrome (MS). Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels. Methods. Rats were divided into control and experimental groups and fed with diets containing 54.5% starch and fructose, respectively, for 4, 12, and 24 weeks. Plasma testosterone and homocysteine levels were measured along with insulin, glucose, and lipids...
2016: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/27813205/dietary-fructose-induced-hepatocellular-carcinoma-development-manifested-in-mice-lacking-apoptosis-inhibitor-of-macrophage-aim
#18
Takayuki Ozawa, Natsumi Maehara, Toshihiro Kai, Satoko Arai, Toru Miyazaki
The consumption of fructose, including the use of high-fructose corn syrup as a sweetener, has increased continuously in recent decades. Although the involvement of fructose in the development of metabolic diseases has been emphasized recently, whether fructose intake increases susceptibility to steatosis-associated hepatocellular carcinoma (HCC) is unclear. Here, we investigated this issue using mice lacking a circulating protein, apoptosis inhibitor of macrophage (AIM, encoded by cd5l). AIM does not induce carcinogenesis of hepatocytes, but provokes necrotic death specifically in AIM-bound cancer cells through complement cascade activation, thereby preventing HCC tumor development in wild-type mice...
November 4, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27803295/strong-antineoplastic-effects-of-metformin-in-preclinical-models-of-liver-carcinogenesis
#19
François Cauchy, Mouniya Mebarki, Benjamin Leporq, Samira Laouirem, Miguel Albuquerque, Simon Lambert, Pierre Bourgoin, Olivier Soubrane, Bernard van Beers, Sandrine Faivre, Pierre Bedossa, Valerie Paradis
Studies suggest that metformin, widely used for treating type 2 diabetes, possesses innate antineoplastic properties. For metabolic syndrome patients with hepatocellular carcinoma, metformin may provide antitumoral effects  We evaluated the impact of metformin on tumor growth and visceral fat composition using relevant preclinical models of metabolic syndrome.  EXPERIMENTAL DESIGN: Studies were performed in three hepatoma cell lines, in HepG2 xenograft mice fed with standard chow-diet (SC), 60% high-fat diet (HFD) or 30% fructose diet (FR), and an ex vivo model of human cultured hepatocellular carcinoma slices...
November 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27803186/metabolism-of-toxic-sugars-by-strains-of-the-bee-gut-symbiont-gilliamella-apicola
#20
Hao Zheng, Alex Nishida, Waldan K Kwong, Hauke Koch, Philipp Engel, Margaret I Steele, Nancy A Moran
: Social bees collect carbohydrate-rich food to support their colonies, and yet, certain carbohydrates present in their diet or produced through the breakdown of pollen are toxic to bees. The gut microbiota of social bees is dominated by a few core bacterial species, including the Gram-negative species Gilliamella apicola We isolated 42 strains of G. apicola from guts of honey bees and bumble bees and sequenced their genomes. All of the G. apicola strains share high 16S rRNA gene similarity, but they vary extensively in gene repertoires related to carbohydrate metabolism...
November 1, 2016: MBio
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