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High fructose diet

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https://www.readbyqxmd.com/read/29210119/diets-rich-in-saturated-fat-and-fructose-induce-anxiety-and-depression-like-behaviours-in-the-rat-is-there-a-role-for-lipid-peroxidation
#1
Silvia Gancheva, Bistra Galunska, Maria Zhelyazkova-Savova
Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high-fat diet (HF) and rats fed high-fat and high-fructose diet (HFHF). HF and HFHF animals were also given a 10% fructose solution as drinking water...
December 6, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29201200/effect-of-a-stilbene-glycoside-rich-extract-from-polygoni-multiflori-radix-on-experimental-non-alcoholic-fatty-liver-disease-based-on-principal-component-and-orthogonal-partial-least-squares-discriminant-analysis
#2
Zhaohuan Lou, Bohou Xia, Jie Su, Jingjing Yu, Meiqiu Yan, Yuefang Huang, Guiyuan Lv
Polygoni Multiflori Radix is a traditional Chinese medicine used clinically to support the functions of the liver and kidneys and to treatment hyperlipidemia. In previous studies, an effective fraction, rich in 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside (TSG), was separated from Polygoni Multiflori Radix and demonstrated hypolipidemic activity. The present study aimed to systematically assess the effect of this fraction on non-alcoholic fatty liver disease (NAFLD). A NAFLD model was established by feeding Sprague-Dawley rats a high-fat diet with 10% fructose solution for 18 weeks...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201096/antihyperglycemic-effect-of-rosa-damascena-is-mediated-by-ppar-%C3%AE-gene-expression-in-animal-model-of-insulin-resistance
#3
Abbas Mohammadi, Hossein Fallah, Ahmad Gholamhosseinian
Insulin resistance is a condition in which insulin signaling and action are impaired in insulin sensitive tissues and result in hyperglycemia, hyperlipidemia, and type 2 diabetes mellitus. Our previous studies have shown that Rosa damascena has antihyperglycemic effects on diabetic and normal rats. Therefore, we conducted a study to evaluate the effect of this medicinal plant on insulin sensitivity in rats. This study was performed on high fructose diet insulin resistant rats and pioglitazone, an insulin sensitizing drug, was used as a positive control...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29196931/metabolic-syndrome-and-bone-pharmacologically-induced-diabetes-has-deleterious-effect-on-bone-in-growing-obese-rats
#4
Cedo M Bagi, Kristin Edwards, Edwin Berryman
Metabolic syndrome and osteoporosis share similar risk factors. Also, patients with diabetes have a higher risk of osteoporosis and fracture. Liver manifestations, such as non-alcoholic steatohepatitis (NASH), of metabolic syndrome are further aggravated in diabetics and often lead to liver failure. Our objective was to create a rat model of human metabolic syndrome and determine the long-term impact of early-onset T1D on bone structure and strength in obese growing rats. Male rats were given either standard chow and RO water (Controls) or a high-fat, high-cholesterol diet and sugar water containing 55% fructose and 45% glucose (HFD)...
December 1, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29196002/in-vitro-and-in-vivo-assessment-of-anti-hyperglycemic-and-antioxidant-effects-of-oak-leaves-quercus-convallata-and-quercus-arizonica-infusions-and-fermented-beverages
#5
Claudia I Gamboa-Gómez, Luis E Simental-Mendía, Rubén F González-Laredo, Esteban J Alcantar-Orozco, Victor H Monserrat-Juarez, Julio C Ramírez-España, Jose Alberto Gallegos-Infante, Martha R Moreno-Jiménez, Nuria E Rocha-Guzmán
The aim of this study was to evaluate the anti-hyperglycemic and antioxidant effects of oak leaves infusions and fermented beverages from Quercus convallata and Q. arizonica in vitro and in vivo. Female C57BL/6 mice fed with high saturated fat and fructose diet-induced obesity were treated with oak leaves beverages (200 μL/per day equivalent to 15mg of lyophilized sample/Kg of body weight for infusions and 31mg of lyophilized sample/Kg of body weight for fermented beverages) for 3months and an oral glucose tolerance test (OGTT) was performed...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29193741/energy-expenditure-and-hormone-responses-in-humans-after-overeating-high-fructose-corn-syrup-versus-whole-wheat-foods
#6
Mostafa Ibrahim, Susan Bonfiglio, Mathias Schlögl, Karyne L Vinales, Paolo Piaggi, Colleen Venti, Mary Walter, Jonathan Krakoff, Marie S Thearle
OBJECTIVE: This study sought to understand how the dietary source of carbohydrates, either high-fructose corn syrup (HFCS) or complex carbohydrates, affects energy expenditure (EE) measures, appetitive sensations, and hormones during 24 hours of overfeeding. METHODS: Seventeen healthy participants with normal glucose regulation had 24-hour EE measures and fasting blood and 24-hour urine collection during four different 1-day diets, including an energy-balanced diet, fasting, and two 75% carbohydrate diets (5% fat) given at 200% of energy requirements with either HFCS or whole-wheat foods as the carbohydrate source...
November 28, 2017: Obesity
https://www.readbyqxmd.com/read/29192848/effects-of-resveratrol-on-high-fructose-induced-testis-injury-in-rats
#7
Elif Guzel Meydanli, Asli Gumusel, Serbay Ozkan, Gamze Tanriverdi, M B Can Balci, Seval Develi Is, A Ismet Hazar, Mujdat Uysal, Seldag Bekpinar
This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible restoring effect in this sense. Fructose (30%; w/v) was administered to rats alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr group, destruction of the germinal epithelium led to the detection of immature germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters (p < 0.05), Johnsen's tubular biopsy score values (p < 0...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29191195/maternal-dietary-free-or-bound-fructose-diversely-influence-developmental-programming-of-lipogenesis
#8
Armagan Aytug Yuruk, Reyhan Nergiz-Unal
BACKGROUND: Maternal dietary choices throughout preconception, pregnancy, and lactation irreversibly affect the development of fetal tissues and organs, known as fetal programming. Recommendations tend to emphasize reducing added sugars. However, the impact of maternal dietary free or bound fructose in added sugars on developmental programming of lipogenesis is unknown. METHODS: Virgin Sprague-Dawley rats were randomly divided into five groups. Rats were given feed and plain water (control) or water containing maltodextrin (vehicle), fructose, high-fructose corn syrup (HFCS) containing 55% fructose, sucrose (20% w/v) for 12 weeks before mating and throughout the pregnancy and lactation periods...
December 1, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29168869/amentoflavone-improves-cardiovascular-dysfunction-and-metabolic-abnormalities-in-high-fructose-and-fat-diet-fed-rats
#9
Li Qin, Ying Zhao, Bin Zhang, Yan Li
Metabolic syndrome (MS) is a leading cause of mortality and morbidity in Western countries. Amentoflavone (AMF) is a polyphenolic compound which has been found to exhibit various biological activities. In this study, we investigated the protective effects of AMF against cardiovascular and liver dysfunction in high fructose and fat diet (HFFD)-induced MS rats. AMF could evidently inhibit the changes of general metabolic parameters, including body weight, fat mass, insulin level, and glucose tolerance activity...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29164049/polyphenols-treatment-in-patients-with-nonalcoholic-fatty-liver-disease
#10
Ludovico Abenavoli, Natasa Milic, Francesco Luzza, Luigi Boccuto, Antonino De Lorenzo
Nonalcoholic fatty liver disease (NAFLD) affects 25-30% of the general population worldwide and this high prevalence is linked with lifestyle and dietetic changes, not only in Western countries, but also in the urban areas of developing countries. Several pharmacological approaches were proposed in the treatment of NAFLD, but the reported results are inconclusive. International guidelines recommended the reduction of dietary fat and fructose, in association with some physical activity. In this context, it was reported that the protective effects of traditional Mediterranean diet, related to the high concentration of antioxidant compounds, particularly of polyphenols...
September 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29156529/alpinetin-improved-high-fat-diet-induced-non-alcoholic-fatty-liver-disease-nafld-through-improving-oxidative-stress-inflammatory-response-and-lipid-metabolism
#11
Yong Zhou, Yin-Lu Ding, Jian-Liang Zhang, Peng Zhang, Jin-Qing Wang, Zhao-Hua Li
The non-alcoholic fatty liver disease (NAFLD) has become a serious medical problem and an increasing threat to public health. It is characterized by the abnormal fat accumulation in liver without excessive alcohol intake. The concurrent NAFLD might up-regulate the risk of chronic kidney disease as well as the mortality rate. Though various drugs have been investigated to attenuate NAFLD, further study is still necessary to find new therapeutic strategy and to reveal the underlying molecular mechanism. In the present study, NAFLD animal models were induced by feeding with high fat (HF) diet for 8 weeks...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29151399/effect-of-neonatal-orally-administered-s-allyl-cysteine-in-high-fructose-diet-fed-wistar-rats
#12
B W Lembede, K H Erlwanger, P Nkomozepi, E Chivandi
S-allyl cysteine (SAC) has antioxidant, antidiabetic and antiobesity properties. We hypothesized that neonatal oral administration of SAC would protect rats against neonatal and adulthood high-fructose diet-induced adverse metabolic outcomes in adulthood. In total, 112 (males=56; females=56), 4-day-old Wistar rat pups were randomly allocated to groups and administered the following treatment regimens daily for 15 days from postnatal day (PND) 6-20: group I - 10 ml/kg distilled water, group II - 10 ml/kg 20% fructose solution (FS), group III - 150 mg/kg SAC and group IV - SAC+FS...
November 20, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29149647/dietary-fish-oil-differentially-ameliorates-high-fructose-diet-induced-hepatic-steatosis-and-hyperlipidemia-in-mice-depending-on-time-of-feeding
#13
Katsutaka Oishi, Tatsuya Konishi, Chiaki Hashimoto, Saori Yamamoto, Yoshinori Takahashi, Yasuhiko Shiina
Chrononutrition is the science of nutrition based on chronobiology. Numerous epidemiological studies have shown that fish oil (FO) reduces the risk of cardiovascular events through various actions such as lowering triglycerides. The present study aimed to determine the time of day when the hypertriglyceridemia-decreasing ability of FO is optimal in mice. A high-fructose diet (HFrD) that induces hyperlipidemia in mice was replaced with the same diet containing 4% FO (HFrD-4% FO) at different times of the day for 2 weeks as described below...
October 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29147484/berberis-integerrima-ameliorates-insulin-resistance-in-high-fructose-fed-insulin-resistant-rats
#14
Hossein Fallah, Hamed Akbari, Moslem Abolhassani, Abbas Mohammadi, Ahmad Gholamhosseinian
Objectives: This study was aimed to investigate the effect of Berberis integerrima (B. integerrima) extract on insulin sensitivity in high-fructose-fed insulin-resistant rats. Materials and Methods: Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for 8 weeks. After the first six weeks, the animals were treated with B. integerrima extract or pioglitazone for two weeks...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29141949/microvascular-insulin-resistance-in-skeletal-muscle-and-brain-occurs-early-in-the-development-of-juvenile-obesity-in-pigs
#15
T Dylan Olver, Zachary Ian Grunewald, Thomas J Jurrissen, Rebecca Ek MacPherson, Paul J LeBlanc, Teagan R Schnurbusch, Alana M Czajkowski, Maurice Harold Laughlin, R Scott Rector, Shawn B Bender, Eric M Walters, Craig A Emter, Jaume Padilla
BACKGROUND: Impaired microvascular insulin signaling may develop prior to overt indices of microvascular endothelial dysfunction and represent an early pathological feature of adolescent obesity. Using a translational porcine model of juvenile obesity, we tested the hypotheses that in the early stages of obesity development, impaired insulin signaling manifests in skeletal muscle (triceps), brain (prefrontal cortex) and corresponding vasculatures, and that depressed insulin-induced vasodilation is reversible with acute inhibition of protein kinase C beta (PKCβ)...
November 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29124251/trail-deletion-prevents-liver-but-not-adipose-tissue-inflammation-during-murine-diet-induced-obesity
#16
Petra Hirsova, Peggy Weng, Warda Salim, Steven F Bronk, Thomas S Griffith, Samar H Ibrahim, Gregory J Gores
Background & Aim: TNF-related apoptosis-inducing ligand (TRAIL) and its cognate receptor(s) are upregulated in human and murine nonalcoholic steatohepatitis (NASH). However, the consequence of this enhanced expression on NASH pathogenesis remains unclear. TRAIL may either accentuate liver injury by promoting hepatic steatosis and inflammation, or it may mitigate the disease process by improving systemic insulin resistance and averting hepatic fibrosis. Herein, we investigated the role of TRAIL in an obesity-induced murine model of NASH...
September 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29118995/added-fructose-as-a-principal-driver-of-non-alcoholic-fatty-liver-disease-a-public-health-crisis
#17
EDITORIAL
James J DiNicolantonio, Ashwin M Subramonian, James H O'Keefe
Fatty liver disease affects up to one out of every two adults in the western world. Data from animal and human studies implicate added sugars (eg, sucrose and high-fructose corn syrup) in the development of fatty liver disease and its consequences. Added fructose in particular, as a component of added sugars, may pose the greatest risk for fatty liver disease. Considering that there is no requirement for added sugars in the diet, dietary guidelines should recommend reducing the intake of added sugars to just 5% of total calories in order to decrease the prevalence of fatty liver disease and its related consequences...
2017: Open Heart
https://www.readbyqxmd.com/read/29117620/the-effects-of-a-modified-high-carbohydrate-high-fat-diet-on-metabolic-syndrome-parameters-in-male-rats
#18
Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana
Metabolic syndrome is a cluster of metabolic abnormalities including central obesity, hyperglycemia, hypertension, and dyslipidemia. A previous study has established that high-carbohydrate high-fat diet (HCHF) can induce MetS in rats. In this study, we modified components of the diet so that it resembled the diet of Southeast Asians. This study aimed to determine the effects of this modified HCHF diet on metabolic parameters in rats. Male Wistar rats (n=14) were randomised into two groups. The normal group was given standard rat chow...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29114945/hyperglycemia-induced-by-chronic-i-p-and-oral-glucose-loading-leads-to-hypertension-through-increased-na-retention-in-proximal-tubule
#19
Selim Fakhruddin, Wael A Alanazi, Hussain N Alhamami, Karen P Briski, Keith E Jackson
Feeding animals glucose, fructose, sucrose, and fat-enriched diets can lead to diet-induced hyperglycemia, severity of which largely depends on type and concentration of nutrients used and length of dietary intervention. As a strategy of dietary intervention, we adopted glucose-enriched diet, drinking water, and intraperitoneal (i.p.) glucose injection at the dose previously determined to be effective to establish a sustained hyperglycemia over a period of 2 weeks. In our current study, we used 4 groups of Sprague Dawley rats: control, glucose-treated, glucose+tempol, and glucose+captopril-treated groups...
November 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29113028/restoration-of-a-healthy-intestinal-microbiota-normalizes-portal-hypertension-in-a-rat-model-of-nonalcoholic-steatohepatitis
#20
Teresa García-Lezana, Imma Raurell, Miren Bravo, Manuel Torres-Arauz, María Teresa Salcedo, Alba Santiago, Andreu Schoenenberger, Chaysavanh Manichanh, Joan Genescà, María Martell, Salvador Augustin
Portal hypertension (PH) drives most of the clinical complications in chronic liver diseases. However, its progression in nonalcoholic steatohepatitis (NASH) and its association with the intestinal microbiota (IM) has been scarcely studied. Our aim was to investigate the role of IM in the mechanisms leading to PH in early NASH. The experimental design was divided in two stages: Stage 1: Sprague-Dawley rats were fed for 8 weeks with high-fat diet and high-glucose/fructose syrup (HFGFD) or control diet/water (CD)...
November 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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