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High fructose diet

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https://www.readbyqxmd.com/read/28430983/absence-of-endothelial-er%C3%AE-results-in-arterial-remodeling-and-decreased-stiffness-in-western-diet-fed-male-mice
#1
Camila Manrique-Acevedo, Francisco I Ramirez-Perez, Jaume Padilla, Victoria J Vieira-Potter, Annayya R Aroor, Brady J Barron, Dongqing Chen, Dominic Haertling, Cory Declue, James R Sowers, Luis A Martinez-Lemus
The role of estrogen receptor alpha (ERα) signaling in the vasculature of females has been described under different experimental conditions and our group recently reported that lack of endothelial ERα in female mice fed a Western diet (WD) results in amelioration of vascular stiffness. Conversely, the role of ERα in the male vasculature in this setting has not been explored. In conditions of over-nutrition and insulin resistance, augmented arterial stiffness, endothelial dysfunction and arterial remodeling contribute to the development of cardiovascular disease...
April 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28428736/simple-sugar-supplementation-abrogates-exercise-induced-increase-in-hepcidin-in-young-men
#2
Maja Tomczyk, Jakub Kortas, Damian Flis, Wojciech Skrobot, Rafal Camilleri, Jedrzej Antosiewicz
BACKGROUND: At present many young people experience too much body iron accumulation. The reason of this phenomenon is not clear. There is accumulating evidences that not proper diet and lack of exercise could be a main contributing factors. This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is hormone regulating iron metabolism. METHODS: A group of physically active young men completed an incremental exercise test before and after a 3-day diet supplemented with fructose (4 g/kg BM) or glucose (4 g/kg BM)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28420148/differential-effect-of-sucrose-and-fructose-in-combination-with-a-high-fat-diet-on-intestinal-microbiota-and-kidney-oxidative-stress
#3
Adriana Rosas-Villegas, Mónica Sánchez-Tapia, Azalia Avila-Nava, Victoria Ramírez, Armando R Tovar, Nimbe Torres
There is controversial information about the adverse effect of sucrose (S) or fructose (F) in the development of obesity. Thus, the purpose of the study was to evaluate the effect of S or F in a high fat diet (HF) on gut microbiota and renal oxidative stress. Rats were fed for four months with either high-fat + sucrose (HFS) or high-fat + fructose (HFF) or a control diet (C). Half of the HFS or HFF groups were maintained with the same diet and the other half were switched to the consumption of C. HFS and HFF groups increased 51% and 19% body weight, respectively, compared with the C group...
April 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28420091/dietary-sugars-and-endogenous-formation-of-advanced-glycation-endproducts-emerging-mechanisms-of-disease
#4
REVIEW
Manuela Aragno, Raffaella Mastrocola
The rapid increase in metabolic diseases, which occurred in the last three decades in both industrialized and developing countries, has been related to the rise in sugar-added foods and sweetened beverages consumption. An emerging topic in the pathogenesis of metabolic diseases related to modern nutrition is the role of Advanced Glycation Endproducts (AGEs). AGEs can be ingested with high temperature processed foods, but also endogenously formed as a consequence of a high dietary sugar intake. Animal models of high sugar consumption, in particular fructose, have reported AGE accumulation in different tissues in association with peripheral insulin resistance and lipid metabolism alterations...
April 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28412321/egcg-ameliorates-diet-induced-metabolic-syndrome-associating-with-the-circadian-clock
#5
Yashi Mi, Guoyuan Qi, Rong Fan, Xiaohua Ji, Zhigang Liu, Xuebo Liu
In response to the daily light-dark (LD) cycle, organisms on Earth have evolved with the approximately 24-h endogenous oscillations to coordinate behavioral and physiological processes, including feeding, sleep, and metabolism homeostasis. Circadian desynchrony triggered by an energy-dense diet rich in fats and fructose is intimately connected with a series of metabolic disorders. Previous studies revealed that (-)-Epigallocatechin-3-gallate (EGCG) could mitigate metabolic misalignment; however, only a few reports have focused on its potential effect on directly manipulating circadian rhythms to ameliorate metabolic syndrome...
April 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28408634/moderate-20-fructose-enriched-diet-stimulates-salt-sensitive-hypertension-with-increased-salt-retention-and-decreased-renal-nitric-oxide
#6
Kevin L Gordish, Kamal M Kassem, Pablo A Ortiz, William H Beierwaltes
Previously, we reported that 20% fructose diet causes salt-sensitive hypertension. In this study, we hypothesized that a high salt diet supplemented with 20% fructose (in drinking water) stimulates salt-sensitive hypertension by increasing salt retention through decreasing renal nitric oxide. Rats in metabolic cages consumed normal rat chow for 5 days (baseline), then either: (1) normal salt for 2 weeks, (2) 20% fructose in drinking water for 2 weeks, (3) 20% fructose for 1 week, then fructose + high salt (4% NaCl) for 1 week, (4) normal chow for 1 week, then high salt for 1 week, (5) 20% glucose for 1 week, then glucose + high salt for 1 week...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28398243/neonatal-citrulline-supplementation-and-later-exposure-to-a-high-fructose-diet-in-rats-born-with-a-low-birth-weight-a-preliminary-report
#7
Nhat-Thang Tran, Marie-Cécile Alexandre-Gouabau, Anthony Pagniez, Khadija Ouguerram, Clair-Yves Boquien, Norbert Winer, Dominique Darmaun
A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age...
April 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28397867/oxidative-stress-causes-hypertension-and-activation-of-nuclear-factor-%C3%AE%C2%BAb-after-high-fructose-and-salt-treatments
#8
Waleska C Dornas, Leonardo M Cardoso, Maísa Silva, Natália L S Machado, Deoclécio A Chianca-Jr, Andréia C Alzamora, Wanderson G Lima, Vincent Lagente, Marcelo E Silva
There is evidence that diets rich in salt or simple sugars as fructose are associated with abnormalities in blood pressure regulation. However, the mechanisms underlying pathogenesis of salt- and fructose-induced kidney damage and/or consequent hypertension yet remain largely unexplored. Here, we tested the role of oxidative state as an essential factor along with high salt and fructose treatment in causing hypertension. Fischer male rats were supplemented with a high-fructose diet (20% in water) for 20 weeks and maintained on high-salt diet (8%) associate in the last 10 weeks...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386998/metabolic-syndrome-induced-bladder-cannabinoid-receptor-changes-in-the-fructose-fed-rats
#9
I-Hung Chen, Juei-Tang Cheng, Yat-Ching Tong
OBJECTIVES: To investigate the effect of metabolic syndrome on the bladder cannabinoid receptors 1 and 2 (CB1/CB2) expression and function in the fructose-fed rats (FR). METHODS: Adult male Sprague-Dawley rats were divided into two groups: (i) Control rats fed with normal chow; and (ii) Rats fed with high-fructose diet (FR) for 9 weeks. The body weight, blood pressure, plasma sugar, insulin, triglyceride and cholesterol were measured. Bladder muscle strips were prepared in organ bath and pre-contracted with 1 µM/L acetylcholine (ACh) or 50 mM/L KCl...
April 6, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28380527/modulation-of-intestinal-cell-differentiation-in-growing-pigs-is-dependent-on-the-fiber-source-in-the-diet
#10
M Saqui-Salces, Z Huang, M Ferrandis Vila, J Li, J A Mielke, P E Urriola, G C Shurson
Feeding high-fiber diets decreases cost, but also caloric and nutritional efficiency by modifying intestinal morphology and function. We analyzed the changes in intestinal cell composition, nutrient transporters and receptors, and cell differentiation induced by fibers from different sources. Forty-six finishing pigs (BW 84 ± 7 kg) were fed 1 of 4 diets: corn-soybean (Control; = 12), 23% wheat straw (WS; = 11), 55% corn distillers dried grains with solubles (DDGS; = 11), and 30% soybean hulls (SBH; = 12). Pigs were fed 2 meals daily to an amount equivalent to 2...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28372462/polysaccharides-extraction-from-opuntia-stricta-and-their-protective-effect-against-hepg2-cell-death-and-hypolipidaemic-effects-on-hyperlipidaemia-rats-induced-by-high-fat-diet
#11
Bahira Harrabi, Khaled Athmouni, Latifa Hamdaoui, Lobna Ben Mahmoud, Ahmed Hakim, Abdelfattah El Feki, Khaled Zeghal, Hanéne Ghozzi
The aim of this study was to analyse cytoprotective effect of polysaccharides compound from Opuntia stricta (O. stricta) cladode (POS) in vitro including its radical scavenging activities and protective effects against hypercholesterolaemia. Our results showed that glucose was the dominant monosaccharides (30.35%). Arabinose, pyranose, fructose, galactose, glucose, sorbitol, S-inositol, M-inositol, trehalose and saccharose found in this species. O. stricta polysaccharides did not cause any cytotoxic effect on HepG2 cells within the range of concentrations tested (0-400 μgml(-1))...
April 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28371239/the-mediterranean-dietary-pattern-as-the-diet-of-choice-for-nafld-evidence-and-plausible-mechanisms
#12
Shira Zelber-Sagi, Federico Salomone, Liat Mlynarsky
Non-alcoholic fatty liver disease (NAFLD) has become a major global health burden, leading to increased risk for cirrhosis, hepatocellular carcinoma, type-2 diabetes and cardiovascular disease. Lifestyle intervention aiming at weight reduction is the most established treatment. However, changing the dietary composition even without weight loss can also reduce steatosis and improve metabolic alterations as insulin resistance and lipid profile. The Mediterranean diet (MD) pattern has been proposed as appropriate for this goal, and was recommended as the diet of choice for the treatment of NAFLD by the EASL-EASD-EASO Clinical Practice Guidelines...
April 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28363036/shrimp-oil-extracted-from-the-shrimp-processing-waste-reduces-the-development-of-insulin-resistance-and-metabolic-phenotypes-in-diet-induced-obese-rats
#13
Sandhya Nair, Jacques Gagnon, Claude Pelletier, Nadia Tchoukanova, Junzeng Zhang, H Stephen Ewart, Vanya Ewart, Guangling Jiao, Yanwen Wang
Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (60 kcal% fat) and 20% fructose-drinking water were divided into four groups and treated with the dietary replacement of 0, 10% (SO10), 15% (SO15), or 20% (SO20) of lard with shrimp oil for 10 weeks...
March 31, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28360082/adipose-tissue-supports-normalization-of-macrophage-and-liver-lipid-handling-in-obesity-reversal
#14
Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pacht, Tanya Tarnovsky, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan, Assaf Rudich
Adipose tissue inflammation and dysfunction are considered central in the pathogenesis of obesity-related dys-metabolism, but their role in the rapid metabolic recovery upon obesity reversal is less well-defined. We hypothesized that changes in adipose tissue endocrine and paracrine mechanisms may support the rapid improvement of obesity-induced impairment in cellular lipid handling. C57Bl-6J mice were fed ad-libitum either normal chow (NC) or high-fat diet (HFF) for 10 weeks. A dietary obesity reversal group was fed HFF for 8 weeks, then switched to NC for 2 weeks (HFFNC)...
March 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28356436/intestinal-barrier-function-and-the-gut-microbiome-are-differentially-affected-in-mice-fed-a-western-style-diet-or-drinking-water-supplemented-with-fructose
#15
Valentina Volynets, Sandrine Louis, Dominik Pretz, Lisa Lang, Maureen J Ostaff, Jan Wehkamp, Stephan C Bischoff
Background: The consumption of a Western-style diet (WSD) and high fructose intake are risk factors for metabolic diseases. The underlying mechanisms are largely unclear.Objective: To unravel the mechanisms by which a WSD and fructose promote metabolic disease, we investigated their effects on the gut microbiome and barrier function.Methods: Adult female C57BL/6J mice were fed a sugar- and fat-rich WSD or control diet (CD) for 12 wk and given access to tap water or fructose-supplemented water. The microbiota was analyzed with the use of 16S rRNA gene sequencing...
March 29, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28355557/liver-specific-activation-of-ampk-prevents-steatosis-on-a-high-fructose-diet
#16
Angela Woods, Jennet R Williams, Phillip J Muckett, Faith V Mayer, Maria Liljevald, Mohammad Bohlooly-Y, David Carling
AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the γ1 subunit (γ1(D316A)) that leads to activation of AMPK. We generated mice with this mutation to study the effect of chronic liver-specific activation of AMPK in vivo. Primary hepatocytes isolated from these mice have reduced gluconeogenesis and fatty acid synthesis, but there is no effect on fatty acid oxidation compared to cells from wild-type mice. Liver-specific activation of AMPK decreases lipogenesis in vivo and completely protects against hepatic steatosis when mice are fed a high-fructose diet...
March 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/28353042/beneficial-effects-of-phyllanthus-amarus-against-high-fructose-diet-induced-insulin-resistance-and-hepatic-oxidative-stress-in-male-wistar-rats
#17
Mallaiah Putakala, Sudhakara Gujjala, Srinivasulu Nukala, Saralakumari Desireddy
Insulin resistance (IR) is a characteristic feature of obesity, type 2 diabetes mellitus, and cardiovascular diseases. Emerging evidence suggests that the high-fructose consumption is a potential and important factor responsible for the rising incidence of IR. The present study investigates the beneficial effects of aqueous extract of Phyllanthus amarus (PAAE) on IR and oxidative stress in high-fructose (HF) fed male Wistar rats. HF diet (66% of fructose) and PAAE (200 mg/kg body weight/day) were given concurrently to the rats for a period of 60 days...
March 28, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28347724/metabolic-effects-of-intermittent-access-to-caloric-or-non-caloric-sweetened-solutions-in-mice-fed-a-high-caloric-diet
#18
Marion Soto, Catherine Chaumontet, Patrick C Even, Dalila Azzout-Marniche, Daniel Tomé, Gilles Fromentin
Human consumption of obesogenic diets and soft drinks, sweetened with different molecules, is increasing worldwide, and increases the risk of metabolic diseases. We hypothesized that the chronic consumption of caloric (sucrose, high-fructose corn syrup (HFCS), maltodextrin) and non-caloric (sucralose) solutions under 2-hour intermittent access, alongside the consumption of a high-fat high-sucrose diet, would result in differential obesity-associated metabolic abnormalities in mice. Male C57BL/6 mice had ad libitum access to an HFHS diet and to water (water control group)...
March 24, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28346343/lifetime-exposure-to-a-constant-environment-amplifies-the-impact-of-a-fructose-rich-diet-on-glucose-homeostasis-during-pregnancy
#19
Aleida Song, Stuart Astbury, Abha Hoedl, Brent Nielsen, Michael E Symonds, Rhonda C Bell
The need to refine rodent models of human-related disease is now being recognized, in particular the rearing environment that can profoundly modulate metabolic regulation. Most studies on pregnancy and fetal development purchase and transport young females into the research facility, which after a short period of acclimation are investigated (Gen0). We demonstrate that female offspring (Gen1) show an exaggerated hyperinsulinemic response to pregnancy when fed a standard diet and with high fructose intake, which continues throughout pregnancy...
March 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28344991/antibody-directed-glucocorticoid-targeting-to-cd163-in-m2-type-macrophages-attenuates-fructose-induced-liver-inflammatory-changes
#20
Pia Svendsen, Jonas H Graversen, Anders Etzerodt, Henrik Hager, Rasmus Røge, Henning Grønbæk, Erik I Christensen, Holger J Møller, Hendrik Vilstrup, Søren K Moestrup
Increased consumption of high-caloric carbohydrates contributes substantially to endemic non-alcoholic fatty liver disease in humans, covering a histological spectrum from fatty liver to steatohepatitis. Hypercaloric intake and lipogenetic effects of fructose and endotoxin-driven activation of liver macrophages are suggested to be essential to disease progression. In the present study, we show that a low dose of an anti-CD163-IgG-dexamethasone conjugate targeting the hemoglobin scavenger receptor CD163 in Kupffer cells and other M2-type macrophages has a profound effect on liver inflammatory changes in rats on a high-fructose diet...
March 17, 2017: Molecular Therapy. Methods & Clinical Development
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