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https://www.readbyqxmd.com/read/29897007/an-economic-evaluation-of-tofacitinib-treatment-in-rheumatoid-arthritis-after-methotrexate-or-after-1-or-2-tnf-inhibitors-from-a-u-s-payer-perspective
#1
Lindsay Claxton, Matthew Taylor, Arif Soonasra, Jeffrey A Bourret, Robert A Gerber
BACKGROUND: Treatment cycling with biologic disease-modifying anti-rheumatic drugs, such as tumor necrosis factor inhibitors (TNFi), is common among patients with rheumatoid arthritis (RA) and can result in reduced clinical efficacy and increased economic burden. Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. OBJECTIVE: To evaluate and compare the economic effect of tofacitinib 5 mg twice daily (BID) treatment directly after methotrexate (MTX) in the MTX-inadequate responder population, or after MTX and 1 TNFi (adalimumab [ADA] or etanercept [ETN]) or 2 TNFi (ADA and ETN) in TNF-inadequate responder patients with RA, from a U...
June 13, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29738806/an-embedded-implementation-based-on-adaptive-filter-bank-for-brain-computer-interface-systems
#2
Kais Belwafi, Olivier Romain, Sofien Gannouni, Fakhreddine Ghaffari, Ridha Djemal, Bouraoui Ouni
BACKGROUND: Brain-computer interface (BCI) is a new communication pathway for users with neurological deficiencies. The implementation of a BCI system requires complex electroencephalography (EEG) signal processing including filtering, feature extraction and classification algorithms. Most of current BCI systems are implemented on personal computers. Therefore, there is a great interest in implementing BCI on embedded platforms to meet system specifications in terms of time response, cost effectiveness, power consumption, and accuracy...
May 5, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29582631/effect-of-an-educational-intervention-based-on-protection-motivation-theory-on-preventing-cervical-cancer-among-marginalized-women-in-west-iran
#3
Shabnam Malmir, Majid Barati, Ali Khani Jeihooni, Saeed Bashirian, Seyed Mohammad Mehdi Hazavehei
Objective: This study aimed to determine the effectiveness of an educational intervention to prevent cervical cancer among marginalized Iranianwomen based on the Protection Motivation Theory (PMT) as a theoretical framework. Methods: This quasi-experimental study was carried out on 143 women of Kermanshah City in western Iran during 2017. Participants were recruited through cluster and simple random sampling and randomly divided into experimental (n=72) and control groups (n=71). All completed a self-administered questionnaire including PMT constructs and demographic variables...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29572095/a-simple-diet-and-chemical-induced-murine-nash-model-with-rapid-progression-of-steatohepatitis-fibrosis-and-liver-cancer
#4
Takuma Tsuchida, Youngmin A Lee, Naoto Fujiwara, Maria Ybanez, Brittany Allen, Sebastiao Martins, M Isabel Fiel, Nicolas Goossens, Hsin-I Chou, Yujin Hoshida, Scott L Friedman
BACKGROUND AND AIMS: Although the majority of patients with non-alcoholic fatty liver disease (NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic steatohepatitis (NASH), which can lead to cirrhosis and hepatocellular carcinoma (HCC). Many established diet-induced mouse models for NASH require 24-52 weeks, which makes testing for drug response costly and time consuming. METHODS: We have sought to establish a murine NASH model with rapid progression of extensive fibrosis and HCC by using a western diet (WD), which is high-fat, high-fructose and high-cholesterol, combined with low weekly dose of intraperitoneal carbon tetrachloride (CCl4 ), which serves as an accelerator...
March 21, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29277649/musical-genre-dependent-behavioural-and-eeg-signatures-of-action-planning-a-comparison-between-classical-and-jazz-pianists
#5
R Bianco, G Novembre, P E Keller, A Villringer, D Sammler
It is well established that musical training induces sensorimotor plasticity. However, there are remarkable differences in how musicians train for proficient stage performance. The present EEG study outlines for the first time clear-cut neurobiological differences between classical and jazz musicians at high and low levels of action planning, revealing genre-specific cognitive strategies adopted in production. Pianists imitated chord progressions without sound that were manipulated in terms of harmony and context length to assess high-level planning of sequence-structure, and in terms of the manner of playing to assess low-level parameter specification of single acts...
April 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29191068/an-exploratory-cost-effectiveness-analysis-of-systemic-treatments-for-cutaneous-t-cell-lymphoma
#6
Larisa Geskin, Daniel C Malone
PURPOSE: To conduct an exploratory cost-effectiveness analysis of systemic treatment options for more advanced cutaneous T-cell lymphoma (CTCL). METHODS: A cost-effectiveness model compared systemic bexarotene, denileukin diftitox, interferon-α, methotrexate, pralatrexate, romidepsin, vorinostat, and extracorporeal photopheresis (ECP) treatment of CTCL. Treatment effectiveness data were extracted from published studies and/or US product labeling. Overall response, the primary effectiveness measure, was defined as the proportion of patients achieving complete or partial response...
December 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29080475/an-electrophysiological-investigation-of-reinforcement-effects-in-attention-deficit-hyperactivity-disorder-dissociating-cue-sensitivity-from-down-stream-effects-on-target-engagement-and-performance
#7
Georgia Chronaki, Fruzsina Soltesz, Nicholas Benikos, Edmund J S Sonuga-Barke
OBJECTIVE: Neural hypo-sensitivity to cues predicting positive reinforcement has been observed in ADHD using the Monetary Incentive Delay (MID) task. Here we report the first study using an electrophysiological analogue of this task to distinguish between (i) cue related anticipation of reinforcement and downstream effects on (ii) target engagement and (iii) performance in a clinical sample of adolescents with ADHD and controls. METHODS: Thirty-one controls and 32 adolescents with ADHD aged 10-16 years performed the electrophysiological (e)-MID task - in which preparatory cues signal whether a response to an upcoming target will be reinforced or not - under three conditions; positive reinforcement, negative reinforcement (response cost) and no consequence (neutral)...
December 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28968211/h2o2-sensing-through-electrochemically-deposited-thionine-coated-ito-thin-film
#8
P Singh, S Srivastava, S K Singh
Progression and initiation of different diseases including pulmonary diseases, alzheimer's and tumors are linked with the oxidative stress, an important cause of cell damage. Different antioxidant enzymes are involved in detoxifying reactive oxygen species including hydrogen peroxide (H2O2) that is generated in response to various stimuli and has important role in cell activation & bio-signaling processes. Herein, we developed hydrogen peroxide electrochemical sensor based on horseradish peroxidase (HRP) entrapped polymerized thionine (PTH) film...
July 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28956154/sources-of-interference-in-cross-modal-action-response-selection-crosstalk-and-general-dual-execution-costs
#9
Aleks Pieczykolan, Lynn Huestegge
Performing several actions simultaneously usually yields interference, which is commonly explained by referring to theoretical concepts such as crosstalk and structural limitations associated with response selection. While most research focuses on dual-task scenarios (involving two independent tasks), we here study the role of response selection and crosstalk for the control of cross-modal response compounds (saccades and manual responses) triggered by a single stimulus. In two experiments, participants performed single responses and spatially compatible versus incompatible dual-response compounds (crosstalk manipulation) in conditions with or without response selection requirements (i...
January 2018: Psychological Research
https://www.readbyqxmd.com/read/28926026/conceptual-models-underlying-economic-analysis-of-animal-health-and-welfare-with-the-inclusion-of-three-components-people-products-and-resources
#10
REVIEW
D A Hennessy
Infectious animal diseases can spill across farm boundaries, so effective management requires coordinated responses. Costs and benefits from the management of infectious diseases are such that those who make the decisions have weak incentives to act, the levels of goods and services produced from animal agriculture are probably smaller than is socially optimal and resources are likely wasted. This work provides an overview of the existing literature on conceptual economic models in animal disease management, paying particular attention to inadequate incentives to make the required biosecurity efforts...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28894554/exploring-the-adaptive-experiences-of-children-with-parents-of-myocardial-infarction-a-qualitative-study
#11
Tahere Hashemifard, Ali Akbar Vaezi, Seyed Saeed Mazloomy, Tahere Kamalikhah, Mehdi Khankolabi, Abbas Andishmand, Mohammad Hossein Baghianimoghadam
BACKGROUND: Cardiovascular diseases are the world's leading cause of mortality. These diseases are rooted in an unhealthy lifestyle. In order to confront this subject, it is essential to identify several risk factors that contribute to heart disease (HD) in people with different attitudes, values, beliefs, expectations and motivations. This study was therefore an attempt to explain the adaptive experiences of children whose parents were involved in myocardial infarction since they were more likely subjected to get the so-called disease...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28832876/addiction-potential-of-cigarettes-with-reduced-nicotine-content-in-populations-with-psychiatric-disorders-and-other-vulnerabilities-to-tobacco-addiction
#12
RANDOMIZED CONTROLLED TRIAL
Stephen T Higgins, Sarah H Heil, Stacey C Sigmon, Jennifer W Tidey, Diann E Gaalema, John R Hughes, Maxine L Stitzer, Hanna Durand, Janice Y Bunn, Jeff S Priest, Christopher A Arger, Mollie E Miller, Cecilia L Bergeria, Danielle R Davis, Joanna M Streck, Derek D Reed, Joan M Skelly, Lauren Tursi
Importance: A national policy is under consideration to reduce the nicotine content of cigarettes to lower nicotine addiction potential in the United States. Objective: To examine how smokers with psychiatric disorders and other vulnerabilities to tobacco addiction respond to cigarettes with reduced nicotine content. Design, Setting, and Participants: A multisite, double-blind, within-participant assessment of acute response to research cigarettes with nicotine content ranging from levels below a hypothesized addiction threshold to those representative of commercial cigarettes (0...
October 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28749603/protection-motivation-theory-in-predicting-intention-to-receive-cervical-cancer-screening-in-rural-chinese-women
#13
Yang Bai, Qing Liu, Xinguang Chen, Yanduo Gao, Huiyun Gong, Xiaodong Tan, Min Zhang, Jiyu Tuo, Yuling Zhang, Qunying Xiang, Fenghua Deng, Guiling Liu
OBJECTIVE: Despite the significance of cervical cancer screening, motivating more women to participate remains a challenge in resource-limited settings. In this study, we tested the protection motivation theory (PMT) in predicting screening intentions. METHODS: Participants were women from Wufeng, a typical rural county in China. Participants (n = 3000) with no cervical cancer history were recruited from 10 randomly selected villages. As mediating variables, 6 PMT constructs (Perceived Risk, Fear Arousal, Perceived Severity, Response Efficacy, Response Cost, and Self-Efficacy) were measured using the standardized questionnaire...
February 2018: Psycho-oncology
https://www.readbyqxmd.com/read/28747679/gambling-like-behavior-in-pigeons-jackpot-signals-promote-maladaptive-risky-choice
#14
Aaron P Smith, Joshua S Beckmann, Thomas R Zentall
Individuals often face choices that have uncertain outcomes and have important consequences. As a model of this environment, laboratory experiments often offer a choice between an uncertain, large reward that varies in its probability of delivery against a certain but smaller reward as a measure of an individual's risk aversion. An important factor generally lacking from these procedures are gambling related cues that may moderate risk preferences. The present experiment offered pigeons choices between unreliable and certain rewards but, for the Signaled group on winning choices, presented a 'jackpot' signal prior to reward delivery...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28737025/-influence-of-initial-protocolized-treatment-with-steroids-in-length-of-stay-and-costs-of-community-acquired-pneumonia
#15
J Gómez Gómez, J L Gómez Torres, A Hernández Torres, J A García Córdoba, M Canteras Jordana
OBJECTIVE: The aim of the study was to analyze the impact of steroid treatment in patients with community acquired pneumonia (CAP), both in length of stay and economical cost of admission at a clinical university hospital. METHODS: Prospective study of admitted patients with the diagnosis of CAP, both in Internal Medicine and Infectious diseases department. The study was conducted from January to march 2015; patients receiving steroids from diagnosis to end of antibiotic treatment were classified as group I; otherwise, they were considered in group II...
October 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28716966/hierarchically-organized-medial-frontal-cortex-basal-ganglia-loops-selectively-control-task-and-response-selection
#16
Franziska M Korb, Jiefeng Jiang, Joseph A King, Tobias Egner
Adaptive behavior requires context-sensitive configuration of task-sets that specify time-varying stimulus-response mappings. Intriguingly, response time costs associated with changing task-sets and motor responses are known to be strongly interactive: switch costs at the task level are small in the presence of a response-switch but large when accompanied by a response-repetition, and vice versa for response-switch costs. The reasons behind this well known interdependence between task- and response-level control processes are currently not well understood...
August 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28469437/predicting-adherence-to-aromatase-inhibitor-therapy-among-breast-cancer-survivors-an-application-of-the-protection-motivation-theory
#17
Monita Karmakar, Sharrel L Pinto, Timothy R Jordan, Iman Mohamed, Monica Holiday-Goodman
The purpose of this observational study was to determine if the Protection Motivation Theory could predict and explain adherence to aromatase inhibitor (AI) therapy among breast cancer survivors. Purposive sampling was used to identify 288 survivors who had been prescribed AI therapy. A valid and reliable survey was mailed to survivors. A total of 145 survivors completed the survey. The Morisky scale was used to measure adherence to AI. The survivors reported a mean score of 6.84 (±0.66) on the scale. Nearly 4 in 10 survivors (38%) were non-adherent...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28467688/effectiveness-and-cost-of-hepatitis-c-virus-cryoglobulinaemia-vasculitis-treatment-from-interferon-based-to-direct-acting-antivirals-era
#18
Patrice Cacoub, Mathieu Vautier, Anne Claire Desbois, Antoine Lafuma, David Saadoun
BACKGROUND: The net benefits of new hepatitis C virus (HCV) direct-acting antiviral drugs (DAA) in patients with cryoglobulinaemia vasculitis (CryoVas) are unknown. OBJECTIVE: To analyse the effectiveness and cost of all treatments used for HCV-CryoVas in the DAA vs pre-DAA era. METHODS: A chart review of all HCV-CryoVas patients who received antivirals from 1993 to 2016 in a tertiary centre was performed. Treatment effectiveness was analysed for clinical, immunological and virological responses...
December 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28439249/cross-modal-action-complexity-action-and-rule-related-memory-retrieval-in-dual-response-control
#19
Aleks Pieczykolan, Lynn Huestegge
Normally, we do not act within a single effector system only, but rather coordinate actions across several output modules (cross-modal action). Such cross-modal action demands can vary substantially with respect to their complexity in terms of the number of task-relevant response combinations and to-be-retrieved stimulus-response (S-R) mapping rules. In the present study, we study the impact of these two types of cross-modal action complexity on dual-response costs (i.e., performance differences between single- and dual-action demands)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28131395/an-expensive-adult-measles-outbreak-and-response-in-office-buildings-during-the-era-of-accelerated-measles-elimination-beijing-china
#20
Rui Ma, Li Lu, Luodan Suo, Xiaomei Li, Fan Yang, Tao Zhou, Lijun Zhai, Hongwei Bai, Xinghuo Pang
BACKGROUND: Few measles outbreaks among adults are reported in China, and outbreak response costs are seldom documented. We report an adult measles outbreak and response in 4 linked office buildings in Beijing and its associated costs. METHOD: The World Health Organization measles case definitions were used to determine suspected and confirmed measles cases. Surveillance data were used to describe the outbreak, and records and interviews of response staff were used to describe the response...
February 22, 2017: Vaccine
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