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https://www.readbyqxmd.com/read/29236325/aml1-eto-trans-activates-c-kit-expression-through-the-long-range-interaction-between-promoter-and-intronic-enhancer
#1
Ying Tian, Genjie Wang, Qingzhu Hu, Xichun Xiao, Shuxia Chen
The AML1/ETO onco-fusion protein is crucial for the genesis of t(8;21) acute myeloid leukemia (AML) and is well documented as a transcriptional repressor through dominant-negative effect. However, little is known about the transactivation mechanism of AML1/ETO. Through large cohort of patient's expression level data analysis and a series of experimental validation, we report here that AML1/ETO transactivates c-KIT expression through directly binding to and mediating the long-range interaction between the promoter and intronic enhancer regions of c-KIT...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29235956/the-experience-of-korean-nurses-during-the-middle-east-respiratory-syndrome-outbreak
#2
Sook-Bin Im, Steven L Baumann, Mina Ahn, Hyunok Kim, Bock-Hui Youn, MinKyoung Park, Ok-Ja Lee
The authors in this article explore the experiences of eight South Korean nurses during an outbreak of the Middle East Respiratory Syndrome (MERS), which took place in the fall of 2015. These nurses were mandated to remain in isolation in an intensive care unit (ICU) dedicated to the treatment of the patients with the MERS virus for 7 days. Parse's humanbecoming theory was used to frame the discussion. Three themes found in the nurse's stories are discussed: feeling hopeless and cut off, feeling shame and overworked, and feeling pride in fulfilling a duty...
January 2018: Nursing Science Quarterly
https://www.readbyqxmd.com/read/29235516/leveraging-ectopic-hsp90-expression-to-assay-the-presence-of-tumor-cells-and-aggressive-tumor-phenotypes-in-breast-specimens
#3
Brian Crouch, Helen Murphy, Stella Belonwu, Amy Martinez, Jennifer Gallagher, Allison Hall, Mary Scott Soo, Marianne Lee, Philip Hughes, Timothy Haystead, Nirmala Ramanujam
Hsp90 has been studied extensively as a therapeutic target in breast cancer in pre-clinical and clinical trials, demonstrating a variety of roles in metastatic progression. The evidence to date suggests a compelling opportunity to leverage attributes of Hsp90 expression beyond therapeutics with potential applications in breast cancer diagnosis, prognosis, and recurrence risk assessment. In this study, we developed a completely non-destructive strategy using HS-27, a fluorescently-tethered Hsp90 inhibitor, to assay Hsp90 expression on intact tissue specimens with comparable contrast to in vivo administration routes, and demonstrate the feasibility of our approach in breast cancer patients...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235199/adaptation-of-the-bone-marrow-stroma-in-hematopoietic-malignancies-current-concepts-and-models
#4
REVIEW
Ben Doron, Mithila Handu, Peter Kurre
The bone marrow stroma maintains hematopoiesis and coordinately regulates regenerative responses through dynamic interactions with hematopoietic stem and progenitor cells. Recent studies indicate that stromal components in the bone marrow of leukemia patients undergo a process of successive adaptation that in turn exerts dramatic effects on the hematopoietic stem cell compartment and promotes leukemic drug resistance. Functional changes in discrete marrow stromal populations can therefore be considered an aspect of leukemia biogenesis in that they create an aberrant, self-reinforcing microenvironment...
December 13, 2017: Stem Cells
https://www.readbyqxmd.com/read/29234967/finding-efficient-swimming-strategies-in-a-three-dimensional-chaotic-flow-by-reinforcement-learning
#5
K Gustavsson, L Biferale, A Celani, S Colabrese
We apply a reinforcement learning algorithm to show how smart particles can learn approximately optimal strategies to navigate in complex flows. In this paper we consider microswimmers in a paradigmatic three-dimensional case given by a stationary superposition of two Arnold-Beltrami-Childress flows with chaotic advection along streamlines. In such a flow, we study the evolution of point-like particles which can decide in which direction to swim, while keeping the velocity amplitude constant. We show that it is sufficient to endow the swimmers with a very restricted set of actions (six fixed swimming directions in our case) to have enough freedom to find efficient strategies to move upward and escape local fluid traps...
December 14, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29234924/a-new-direction-in-anastomotic-research-should-we-redesign-the-angle-of-sorrow
#6
Omar E Aly
INTRODUCTION: Despite advances in oncological outcomes in colo-rectal surgery, rates of anastomotic leak have not improved. The precise mechanisms of anastomotic leak remain poorly understood. Current research has focused on anastomotic reinforcement to tackle anastomotic leak with little success. The 'Angle of Sorrow', the corner of the anastomosis is prone to anastomotic leak, but remains a persistent feature in the gastrointestinal anastomosis. The tendency for stress forces to concentrate in the vulnerable 'Angle of Sorrow' prompts the need for anastomotic design research...
December 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29234834/contributions-of-prolonged-contingent-and-non-contingent-cocaine-exposure-to-escalation-of-cocaine-intake-and-glutamatergic-gene-expression
#7
Kyle L Ploense, Philip Vieira, Lana Bubalo, Gema Olivarria, Amanda E Carr, Karen K Szumlinski, Tod E Kippin
Similar to the pattern observed in people with substance abuse disorders, laboratory animals will exhibit escalation of cocaine intake when the drug is available over prolonged periods of time. Here, we investigated the contribution of behavioral contingency of cocaine administration on escalation of cocaine intake and gene expression in the dorsal medial prefrontal cortex (dmPFC) in adult male rats. Rats were allowed to self-administer intravenous cocaine (0.25 mg/infusion) under either limited cocaine-(1 h/day), prolonged cocaine-(6 h/day), or limited cocaine-(1 h/day) plus yoked cocaine-access (5 h/day); a control group received access to saline (1 h/day)...
December 12, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29234746/short-implants-as-an-alternative-to-crestal-sinus-lift-a-3-year-multicentre-randomised-controlled-trial
#8
Giorgio Gastaldi, Pietro Felice, Roberto Pistilli, Carlo Barausse, Anna Trullenque-Eriksson, Marco Esposito
PURPOSE: To evaluate the efficacy of short (5 or 6 mm long) dental implants vs 10 mm or longer implants placed in crestally lifted sinuses. MATERIALS AND METHODS: Twenty partially edentulous patients with 5 to 7 mm of residual crestal height and at least 7 mm thickness below the maxillary sinuses as measured on computed tomography scans were randomised according to a parallel group design to receive either one to two 5 or 6 mm long implants (10 patients) or 10 mm long implants (10 patients) after crestal sinus lifting and grafting with anorganic bovine bone...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234676/healing-and-antisecretory-effects-of-aqueous-extract-of-eremomastax-speciosa-acanthaceae-on-unhealed-gastric-ulcers
#9
A P Amang, C Mezui, G T Siwe, J Emakoua, G Mbah, E Z Nkwengoua, G E Enow-Orock, P V Tan
Objective: This work investigated the healing and antisecretory effects of the aqueous extract of Eremomastax speciosa on "unhealed gastric ulcers" associated with gastric acid hypersecretion. Materials and Methods: "Unhealed gastric ulcers" were induced using indomethacin following the establishment of acetic-acid-induced chronic gastric ulcers. The extract (200 and 400 mg/kg, per os) was administered concomitantly with indomethacin (1 mg/kg, subcutaneously)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29234610/a-new-root-strengthening-technique-for-acute-aortic-dissection-with-a-weakened-aortic-root-the-neo-adventitia-technique
#10
Ji Yong Kim, In Ha Kim, Woon Heo, Ho-Ki Min, Do Kyun Kang, Youn-Ho Hwang, Hee Jae Jun
Background: Dissection flaps in acute type A aortic dissection typically extend into the root, most frequently into the non-coronary sinus (NCS). The weakened root can be susceptible not only to surgical trauma, but also to future dilatation because of its thinner layers. Herein, we describe a new technique that we named the "neo-adventitia" technique to strengthen the weakened aortic root. Methods: From 2012 to 2016, 27 patients with acute type A aortic dissection underwent supracommissural graft replacement using our neo-adventitia technique...
December 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29234199/prevalence-and-characteristics-of-hepatitis-delta-virus-infection-in-a-tertiary-hospital-setting-in-cameroon
#11
Henry N Luma, Servais A F B Eloumou, Cécile Okalla, Olivier Donfack-Sontsa, Ruth Koumitana, Agnes Malongue, Georges B Nko'Ayissi, Dominique N Noah
Background/Aims: Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection is associated with more severe liver disease than HBV alone. More knowledge on the epidemiology and clinical impact of HDV-infected individuals is needed in Cameroon.We aimed at determining the frequency of anti-HDV antibody testing in hepatitis B surface antigen (HBsAg) positive patients, the proportion of anti-HDV positivity, and the characteristics of anti-HDV positive compared to anti-HDV negative patients in a tertiary hospital setting in Cameroon...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234169/characterization-of-hybridization-within-a-secondary-contact-region-of-the-inshore-fish-bostrychus-sinensis-in-the-east-china-sea
#12
Shaoxiong Ding, Mrinal Mishra, Haohao Wu, Shuang Liang, Michael M Miyamoto
The northwest Pacific marginal seas are a primary center of phylogeographic and evolutionary research, because of their dynamic geographic history of falling and rising sea levels during the glaciations and interglaciations of the last one million years. Here we present new molecular and morphological data for geographic samples of the four-eyed sleeper (Bostrychus sinensis), which reinforce the evidence for secondary contact and hybridization between two phylogeographic lineages in the East China Sea. Specifically, we find that the secondary contact region is characterized by a low frequency of hybridization, where mitochondrial DNA introgression is relatively common, whereas F1 hybrids are correspondingly scarce...
January 2018: Heredity
https://www.readbyqxmd.com/read/29233885/a-perspective-on-na-and-k-channel-inactivation
#13
REVIEW
Clay M Armstrong, Stephen Hollingworth
We are wired with conducting cables called axons that rapidly transmit electrical signals (e.g., "Ouch!") from, for example, the toe to the spinal cord. Because of the high internal resistance of axons (salt water rather than copper), a signal must be reinforced after traveling a short distance. Reinforcement is accomplished by ion channels, Na channels for detecting the signal and reinforcing it by driving it further positive (to near 50 mV) and K channels for then restoring it to the resting level (near -70 mV)...
December 12, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29233422/implementation-of-a-virtual-dispensing-simulator-to-support-us-pharmacy-education
#14
Marcus Ferrone, Clark Kebodeaux, Jill Fitzgerald, Lisa Holle
INTRODUCTION: A key element for pharmacy practice defined by the Accreditation Council for Pharmacy Education (ACPE) is medication use systems management. A web-based community pharmacy simulation originally created for Australian pharmacy students was adapted for pharmacy students in the United States (US). The objective of this study was to collaboratively adapt an existing international simulation program for utility in the US and measure student perceptions of a web-based community pharmacy simulation program in three US schools of pharmacy...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233420/student-pharmacist-perceived-benefit-of-a-sequential-training-model-for-health-testing
#15
Tiffaney Threatt, Eileen Ward, Kayce Shealy, Amy Hynes, P Elizabeth Robinette
PURPOSE: This article describes the health testing training process used at Presbyterian College School of Pharmacy and evaluates perceptions of the sequential training model among students in their first, second, and third professional years. EDUCATIONAL ACTIVITY AND SETTING: After observing student deficiencies in the knowledge and skills necessary for performing health tests, despite receiving didactic training within the core curriculum, faculty members searched for supplemental training programs used by other schools of pharmacy...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233412/forecasting-academic-success-through-implementation-of-an-online-prerequisite-review-tutorials-program-for-first-year-pharmacy-students
#16
Brendan D Stamper, Amber V Buhler, John P Harrelson, Sigrid C Roberts, Ashim Malhotra, Fawzy A Elbarbry, Deepa Rao, Reza Karimi, R Brigg Turner, Catherine Marlow, Leslie L Devaud
OBJECTIVE: Online prerequisite review (OPR) tutorials were designed and implemented to reinforce foundational scientific material in order to protect in-class time, foster self-directed learning, and ensure all students have similar baseline knowledge. METHODS: Twenty-one tutorials covering undergraduate prerequisite material were developed by faculty and organized into six core modules, comprising basic biology, chemistry, and physiology topics. A quiz on this material was given on the first day of each course...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233408/structured-academic-discussions-through-an-online-education-specific-platform-to-improve-pharm-d-students-learning-outcomes
#17
Srikanth Kolluru, James T Varughese
OBJECTIVE: To facilitate active academic discussions using an online, education-centered platform and reinforce concepts, in order to improve overall course outcomes. MATERIALS AND METHODS: A third year integrated pharmacotherapy course was enrolled on an online searchable platform, Piazza®, to facilitate academic discussions. Students could ask, answer, and explore content, and build on submitted answers in wiki style in collaboration. Instructor posted learning objectives, endorsed student responses with correct answers and led follow-up discussions...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233402/the-use-of-twitter-to-facilitate-engagement-and-reflection-in-a-constructionist-learning-environment
#18
Shane P Desselle
OBJECTIVES: Determine students' self-reported use of Twitter in a health systems course and gauge their perceptions of its value and utility for self-guided supplementation of course material, and evaluate the quality of students' reflections from information they found on Twitter. METHODS: Students in a health systems course create a Twitter account to remain abreast of current developments in pharmacy and health systems. They were afforded the autonomy to follow organizations/individuals they chose and write reflective mini-papers on selected tweets from their Twitter feed prior to each course session...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233376/a-pharmacy-student-s-role-as-a-teaching-assistant-in-an-undergraduate-medicinal-chemistry-course-implementation-evaluation-and-unexpected-opportunities-for-educational-outreach
#19
Matthew J DellaVecchia, Alyssa M Claudio, Jamie L Fairclough
BACKGROUND AND PURPOSE: To describe 1) a pharmacy student's teaching assistant (TA) role in an undergraduate medicinal chemistry course, 2) an active learning module co-developed by the TA and instructor, and 3) the unexpected opportunities for pharmacy educational outreach that resulted from this collaboration. EDUCATIONAL ACTIVITY AND SETTING: Medicinal Chemistry (CHM3413) is an undergraduate course offered each fall at Palm Beach Atlantic University (PBA). As a TA for CHM3413, a pharmacy student from the Gregory School of Pharmacy (GSOP) at PBA co-developed and implemented an active learning module emphasizing foundational medicinal chemistry concepts as they pertain to performance enhancing drugs (PEDs)...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233374/curriculum-renewal-alignment-of-introductory-pharmacy-practice-experiences-with-didactic-course-content
#20
Wesley Nuffer, Sheila Botts, Kari Franson, Eric Gilliam, Randy Knutsen, Monika Nuffer, Elizabeth O'Brien, Joseph Saseen, Megan Thompson, Joseph Vande Griend, Robert Willis
BACKGROUND AND PURPOSE: The University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences (SSPPS) used the opportunity of curriculum renewal to integrate knowledge and skills learned from didactic courses into the introductory pharmacy practice experiences (IPPEs) occurring simultaneously. This paper describes and evaluates the meaningful application of course content into IPPEs, and evaluates the success using qualitative feedback. EDUCATIONAL ACTIVITY AND SETTING: Students entering the renewed curriculum starting in fall 2012 were provided a list of pharmacy skills and activities from didactic course directors that reinforced course content for that semester...
November 2017: Currents in Pharmacy Teaching & Learning
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