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https://www.readbyqxmd.com/read/28441636/psychological-features-and-quality-of-life-in-50-adult-patients-with-epilepsy-and-their-caregivers-from-the-lecco-epilepsy-center-italy
#1
Alessandra Petruzzi, Andrea Rigamonti, Claudia Yvonne Finocchiaro, Paolo Borelli, Elena Lamperti, Antonio Silvani, Rossana Regazzoni, Lorenzo Stanzani, Andrea Salmaggi
Epilepsy is one of the most common neurological disorders. To the best of our knowledge, in Italy, the relationship between patients' and caregivers' psychological state has rarely been analyzed. Thus, we sought to evaluate both the psychological state of patients with epilepsy and that of their caregivers and the interrelationship between them. We also assessed the existing relation between psychological features and some clinical and demographic information, such as number of antiepileptic drugs (AEDs), epilepsy duration and education level of patients and their caregivers...
April 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28441518/learning-to-allocate-limited-time-to-decisions-with-different-expected-outcomes
#2
Arash Khodadadi, Pegah Fakhari, Jerome R Busemeyer
The goal of this article is to investigate how human participants allocate their limited time to decisions with different properties. We report the results of two behavioral experiments. In each trial of the experiments, the participant must accumulate noisy information to make a decision. The participants received positive and negative rewards for their correct and incorrect decisions, respectively. The stimulus was designed such that decisions based on more accumulated information were more accurate but took longer...
April 19, 2017: Cognitive Psychology
https://www.readbyqxmd.com/read/28441503/robust-uniform-and-highly-emissive-quantum-dot-polymer-films-and-patterns-using-thiol-ene-chemistry
#3
Markus Smith, Sidney T Malak, Jaehan Jung, Young Jun Yoon, Chun Hao Lin, Sunghan Kim, Kyung Min Lee, Ruilong Ma, Timothy J White, Timothy J Bunning, Zhiqun Lin, Vladimir V Tsukruk
This work demonstrates a facile and versatile method for generating low scattering crosslinked quantum dots (QD)-polymer composite films and patterned highly emissive structures with ultra-high QD loading, minimal phase-separation, and tunable mechanical properties. Uniform QD-polymer films are fabricated using thiol-ene chemistry, in which cross-linked polymer networks are rapidly produced in ambient conditions via fast UV polymerization in bulk to suppress QD aggregation. UV-controlled thiol-ene chemistry limits phase separation through producing highly QD loaded crosslinked composites with loading rate above majority of those reported in literature (<1%) and approaching 30%...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28441394/maternal-obese-type-gut-microbiota-differentially-impact-cognition-anxiety-and-compulsive-behavior-in-male-and-female-offspring-in-mice
#4
Annadora J Bruce-Keller, Sun-Ok Fernandez-Kim, R Leigh Townsend, Claudia Kruger, Richard Carmouche, Susan Newman, J Michael Salbaum, Hans-Rudolf Berthoud
Maternal obesity is known to predispose offspring to metabolic and neurodevelopmental abnormalities. While the mechanisms underlying these phenomena are unclear, high fat diets dramatically alter intestinal microbiota, and gut microbiota can impact physiological function. To determine if maternal diet-induced gut dysbiosis can disrupt offspring neurobehavioral function, we transplanted high fat diet- (HFD) or control low fat diet-associated (CD) gut microbiota to conventionally-housed female mice. Recipient mice were then bred and the behavioral phenotype of male and female offspring was tracked...
2017: PloS One
https://www.readbyqxmd.com/read/28441344/collagenous-extracellular-matrix-biomaterials-for-tissue-engineering-lessons-from-the-common-sea-urchin-tissue
#5
REVIEW
Kheng Lim Goh, David F Holmes
Scaffolds for tissue engineering application may be made from a collagenous extracellular matrix (ECM) of connective tissues because the ECM can mimic the functions of the target tissue. The primary sources of collagenous ECM material are calf skin and bone. However, these sources are associated with the risk of having bovine spongiform encephalopathy or transmissible spongiform encephalopathy. Alternative sources for collagenous ECM materials may be derived from livestock, e.g., pigs, and from marine animals, e...
April 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28440996/-quality-dimensions-focused-on-the-healthcare-protocol-infarction-code-c%C3%A3-digo-infarto
#6
Jesús Arriaga-Dávila, Gilberto Pérez-Rodríguez, Gabriela Borrayo-Sánchez
The Código Infarto (Infarction Code) strategy is part of the comprehensive care program "A Todo Corazón" (To All Heart), whose aim is to reinforce the prevention and health care of cardiovascular diseases. Mexico faces a big challenge, since it is the country with greater mortality secondary to acute myocardial infarction (AMI) in the first 30 days in patients of 45 years or older (28% compared with 7.9% of the average). In addition, Mexico's population has a high prevalence of risk factors (hypertension, diabetes, tobacco use, dyslipidemias, overweight, and obesity)...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28440812/biobehavioral-effects-of-baclofen-in-anxious-alcohol-dependent-individuals-a-randomized-double-blind-placebo-controlled-laboratory-study
#7
M Farokhnia, M L Schwandt, M R Lee, J W Bollinger, L A Farinelli, J P Amodio, L Sewell, T A Lionetti, D E Spero, L Leggio
Baclofen has been suggested as a potential pharmacotherapy for alcohol use disorder, but the clinical data are conflicting. Here we investigated the biobehavioral effects of baclofen in a sample of anxious alcohol-dependent individuals. This was a randomized, double-blind, placebo-controlled, human laboratory study in non-treatment seeking alcohol-dependent individuals with high trait anxiety (N=34). Participants received baclofen (30 mg per day) or placebo for at least 8 days, then performed an experimental session consisting of alcohol cue-reactivity followed by alcohol administration procedure (alcohol priming, then alcohol self-administration)...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28440810/naltrexone-modulates-dopamine-release-following-chronic-but-not-acute-amphetamine-administration-a-translational-study
#8
N Jayaram-Lindström, J Guterstam, J Häggkvist, M Ericson, T Malmlöf, B Schilström, C Halldin, S Cervenka, T Saijo, A-L Nordström, J Franck
The opioid antagonist naltrexone has been shown to attenuate the subjective effects of amphetamine. However, the mechanisms behind this modulatory effect are currently unknown. We hypothesized that naltrexone would diminish the striatal dopamine release induced by amphetamine, which is considered an important mechanism behind many of its stimulant properties. We used positron emission tomography and the dopamine D2-receptor radioligand [(11)C]raclopride in healthy subjects to study the dopaminergic effects of an amphetamine injection after pretreatment with naltrexone or placebo...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28440719/a-case-based-medical-curriculum-for-the-21st-century-the-use-of-innovative-approaches-in-designing-and-developing-a-case-on-mental-health
#9
Athanasios Hassoulas, Elizabeth Forty, Mathew Hoskins, James Walters, Stephen Riley
The introduction of case-based learning (CBL) by the School of Medicine at Cardiff University has encouraged innovation in medical teaching and learning. During years one and two of the modernized MBBCh program, students complete 17 cases as part of the newly developed C21 curriculum that emphasizes a patient-oriented and student-centered approach to learning. The mental health case, which is presented in year 2, incorporates a number of novel teaching resources that aim to enhance the students' learning experience and to further reinforce the patient-oriented and community-based philosophy of C21...
May 2017: Medical Teacher
https://www.readbyqxmd.com/read/28440486/synergistic-antitumor-effects-of-cdk-inhibitor-sns%C3%A2-032-and-an-oncolytic-adenovirus-co%C3%A2-expressing-trail-and-smac-in-pancreatic-cancer
#10
Yun Ge, Wen Lei, Yingyu Ma, Yigang Wang, Buyun Wei, Xiaoyi Chen, Guoqing Ru, Xianglei He, Xiaozhou Mou, Shibing Wang
Gene therapy using oncolytic adenoviruses is a novel approach for human cancer therapeutics. The current study aimed to investigate whether the combined use of an adenovirus expressing tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) and second mitochondria‑derived activator of caspase (Smac) upon caspase activation (ZD55‑TRAIL‑IETD‑Smac) and cyclin‑dependent kinase (CDK) inhibitor SNS‑032 will synergistically reinforce their anti‑pancreatic cancer activities. The experiments in vitro demonstrated that SNS‑032 enhances ZD55‑TRAIL‑IETD‑Smac‑induced apoptosis and causes marked pancreatic cancer cell death...
April 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440054/a-new-approach-to-obtain-cellulose-nanocrystals-and-ethanol-from-eucalyptus-cellulose-pulp-via-the-biochemical-pathway
#11
Thalita J Bondancia, Luiz Henrique C Mattoso, José M Marconcini, Cristiane S Farinas
The feasibility of integration of cellulosic ethanol production with the manufacture of cellulose nanofibers and cellulose nanocrystals was evaluated using eucalyptus cellulose pulp as feedstock and employing the biochemical route alone. For the enzymatic hydrolysis step, experimental central composite design (CCD) methodology was used as a tool to evaluate the effects of solids loading (SL) and enzymatic loading (EL) on glucose release and cellulose conversion. Glucose concentrations from 45 to 125 g/L were obtained after 24 h, with cellulose conversions from 35 to 96%...
April 25, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28440042/biodegradable-hydrogel-based-biomaterials-with-high-absorbent-properties-for-non-adherent-wound-dressing
#12
Alok Kumar, Xiang Wang, Krishna Chaitanya Nune, Rdk Misra
Dressing materials involve conventional gauzes and modern materials such as hydrogels and foam-based biomaterials. Although the choice of dressing material depends on the type of wound, a dressing material is expected to be non-cytotoxic. Additionally, moist dressing is considered appropriate to accelerate epithelialisation, while dry dressing may cause tissue damage during removal. An ideal dressing material is expected to provide a moist environment and degrade and release the drug for faster wound healing...
April 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28439289/bipolarity-and-suicidal-ideation-in-children-and-adolescents-a-systematic-review-with-meta-analysis
#13
REVIEW
Flórido Sampaio das Neves Peixoto, Danilo Ferreira de Sousa, Dayse Christina Rodrigues Pereira Luz, Nélio Barreto Vieira, Jucier Gonçalves Júnior, Gabriel Cabral Alencar Dos Santos, Flaviane Cristine Troglio da Silva, Modesto Leite Rolim Neto
BACKGROUND: Affective disorders in children and adolescents have received growing attention in the world scenario of mental health. Additionally, there has been an increasing prevalence of suicidal ideation in this population. OBJECTIVE: A systematic review with meta-analysis was conducted to demonstrate the main risk factors regarding the development of suicidal ideation in the bipolar disorder. METHODS: This is a systematic review with meta-analysis using the PRISMA protocol (http://www...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28439076/practice-makes-perfect-self-reported-adherence-a-positive-marker-of-inhaler-technique-maintenance
#14
Elizabeth Azzi, Pamela Srour, Carol Armour, Cynthia Rand, Sinthia Bosnic-Anticevich
Poor inhaler technique and non-adherence to treatment are major problems in the management of asthma. Patients can be taught how to achieve good inhaler technique, however maintenance remains problematic, with 50% of patients unable to demonstrate correct technique. The aim of this study was to determine the clinical, patient-related and/or device-related factors that predict inhaler technique maintenance. Data from a quality-controlled longitudinal community care dataset was utilized. 238 patients using preventer medications where included...
April 24, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28438480/educating-emergency-department-registered-nurses-edrns-in-screening-brief-intervention-and-referral-to-treatment-sbirt-changes-in-attitudes-and-knowledge-over-time
#15
Ann M Mitchell, Irene Kane, Dawn L Lindsay, Holly Hagle, Kathy Puskar, Jim Aiello, Lynn Boucek, Emily Knapp
Alcohol and other drug (AOD) diagnoses in the ED co-occur with injury-related presenting conditions including: falls, motor vehicle accidents, poisonings, and both intentional and unintentional injuries. Clinical attention to ED admissions resulting from hazardous AOD use can significantly improve patient care and reduce high cost utilization of ED visits and treatment. The EDRN-SBIRT project is designed to improve the knowledge and attitudes of ED nurses working in a large academic medical center to identify and address risky AOD use as it relates to an ED visit...
April 21, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28437762/public-attitudes-toward-depression-and-help-seeking-impact-of-the-ospi-europe-depression-awareness-campaign-in-four-european-regions
#16
Elisabeth Kohls, Evelien Coppens, Juliane Hug, Eline Wittevrongel, Chantal Van Audenhove, Nicole Koburger, Ella Arensman, András Székely, Ricardo Gusmão, Ulrich Hegerl
BACKGROUND: Public attitudes toward depression and help-seeking behaviour are important factors influencing depressed people to obtain professional help and adequate treatment. OSPI-Europe is a multi-level suicide prevention programme including a public awareness campaign. It was implemented in four regions of four European countries (Germany, Hungary, Ireland and Portugal). This paper reports the results of the evaluation of the campaign, including its visibility and effects of the campaign on stigma associated with depression and help-seeking behaviour...
April 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28437693/an-assessment-of-the-social-cognitive-predictors-of-exclusive-breastfeeding-behavior-using-the-health-action-process-approach
#17
J L Martinez-Brockman, F M Shebl, N Harari, R Pérez-Escamilla
RATIONALE: In the United States rates of exclusive breastfeeding duration remain exceedingly low. Exclusive breastfeeding is a complex learned behavior that is influenced by social cognitive, interpersonal, and structural factors. Interventions are needed that address factors at multiple levels of the social-ecological model. This study was designed to examine the social cognitive predictors of exclusive breastfeeding behavior in a sample of low-income women attending the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) breastfeeding peer counseling program and enrolled in the Lactation Advice Through Texting Can Help (LATCH) study...
April 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28437613/evaluating-the-role-of-multidrug-resistance-protein-3-mdr3-inhibition-in-predicting-drug-induced-liver-injury-using-125-pharmaceuticals
#18
Michael D Aleo, Falgun Shah, Kan He, Paul D Bonin, A David Rodrigues
The role of bile salt export protein (BSEP) inhibition in drug-induced liver injury (DILI) has been investigated widely, while inhibition of the canalicular multidrug resistant protein 3 (MDR3) has received less attention. This transporter plays a pivotal role in secretion of phospholipids into bile and functions coordinately with BSEP to mediate the formation of bile acid-containing biliary micelles. Therefore, inhibition of MDR3 in human hepatocytes was examined across 125 drugs (70 of Most- and 55 of No-DILI-concern)...
April 24, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28437226/first-report-of-prevalence-of-ctx-m-15-producing-escherichia-coli-o25b-st131-from-iran
#19
Mohammad Hasan Namaei, Masoud Yousefi, Masoud Ziaee, Alireza Salehabadi, Malaknaz Ghannadkafi, Elham Amini, Parvin Askari
The emergence of Escherichia coli sequence type 131 (ST131) as a multidrug-resistant and virulent pathogen represents a major challenge to public health globally. Recently, the O25b/ST131 E. coli producing CTX-M-15 with high virulence potential has been reported worldwide, but has received little attention in Iran. This study is the first in Iran to specifically determine the spread of the O25b/ST131 clone producing CTX-M-15 among E. coli isolates belonging to the B2 phylogenetic group. ST131 clone in phylogenetic group B2 was detected based on PCR detection of ST131-specific single-nucleotide polymorphisms in mdh and gyrB...
February 16, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28437221/the-effect-of-reinforcement-methods-with-knotted-and-knotless-sutures-comparison-of-burst-pressures
#20
Alper Yavuz, Hakan Buluş
Sleeve gastrectomy operations have become popular among restrictive obesity surgeons, due to its effectiveness for losing weight and acceptable complication rates. However, leakage is a significant problem in these operations. In this ex vivo study, we tried to understand mechanisms of leakage and to examine the effects of two different types of frequently referred reinforcement techniques using sutures. The resected gastric specimens that were removed during sleeve gastrectomy operations were used in this ex vivo study...
September 22, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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