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https://www.readbyqxmd.com/read/29054819/high-ambient-temperature-facilitates-the-acquisition-of-3-4-methylenedioxymethamphetamine-mdma-self-administration
#1
Shawn M Aarde, Pai-Kai Huang, Michael A Taffe
RATIONALE: MDMA alters body temperature in rats with a direction that depends on the ambient temperature (TA). The thermoregulatory effects of MDMA and TA may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. OBJECTIVE: To determine how body temperature responses under high and low TA influence MDMA IVSA. METHODS: Male Sprague-Dawley rats were trained to IVSA MDMA (1.0mg/kg/infusion; 2-h sessions; FR5 schedule of reinforcement) under TA 20°C or 30°C...
October 17, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29054591/us-alone-trials-presented-during-acquisition-do-not-disrupt-classical-eyeblink-conditioning-empirical-and-computational-findings
#2
M T Allen, C E Myers, D Williams, R J Servatius
Studies of partial reinforcement in eyeblink conditioning have typically shown slower learning of a CS-US association when paired CS-US trials are interleaved with CS-alone trials. However, recent work has shown that CS-US learning is not slowed by interleaved US-alone trials. This discrepancy is surprising since both partial reinforcement protocols reduce the total number of paired CS-US trials. Previously, Kimble et al. (1955) reported that inserting a block of US-alone trials during CS-US training did not disrupt eyeblink acquisition...
October 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29054400/barriers-to-delirium-assessment-in-the-intensive-care-unit-a-literature-review
#3
REVIEW
Gabby Rowley-Conwy
BACKGROUND: Delirium is a common syndrome that has both short and long-term negative outcomes for critically ill patients. Many studies over several years have found a knowledge gap and lack of evidence-based practice from critical care personnel, but there has been little exploration of the reasons for this. AIM: To identify the perceived barriers to delirium assessment and management among critical care nurses. METHOD: A literature review of published studies to examine barriers to effective delirium assessment using a comprehensive search strategy...
October 17, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29054366/simvastatin-accelerates-hematoma-resolution-after-intracerebral-hemorrhage-in-a-ppar%C3%AE-dependent-manner
#4
Yuelong Wang, Qianwei Chen, Qiang Tan, Zhou Feng, Zhenlin He, Jun Tang, Hua Feng, Gang Zhu, Zhi Chen
To date, the neuroprotective effects of statins on intracerebral hemorrhage (ICH) are not well established. This study explored the effect and potential mechanism of simvastatin treatment on ICH. In the present study, the effects of simvastatin on hematoma absorption, neurological outcome, CD36 expression and microglia polarization were examined in rat model of ICH model. In the meantime, inhibitory effect of PPARγ inhibitor GW9662 was investigated following ICH. Additionally, the effect of simvastatin on PPARγ activation was also investigated in rat ICH model and primary microglia culture...
October 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29054352/patient-related-risk-factors-for-infection-following-open-carpal-tunnel-release-an-analysis-of-over-450-000-medicare-patients
#5
Brian C Werner, Victor A Teran, D Nicole Deal
PURPOSE: To establish the rate of postoperative infection after open carpal tunnel release (CTR) on a national level using an administrative database and define relevant patient-related risk factors associated with its occurrence. METHODS: The PearlDiver patient records database was used to query the 100% Medicare Standard Analytic Files retrospectively from 2005 to 2012 for patients undergoing open CTR using Current Procedural Terminology code 64721. Postoperative infection within 90 days of surgery was assessed using both International Classification of Diseases, Ninth Revision codes for diagnoses of postoperative infection or pyogenic arthritis of the wrist and Current Procedural Terminology codes for procedures for these indications, including either open or arthroscopic irrigation and debridement...
October 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29054163/new-dental-and-postcranial-material-of-agerinia-smithorum-primates-adapiformes-from-the-type-locality-casa-retjo-1-early-eocene-iberian-peninsula
#6
Joan Femenias-Gual, Judit Marigó, Raef Minwer-Barakat, Salvador Moyà-Solà
New material attributed to Agerinia smithorum from Casa Retjo-1 (early Eocene, NE Iberian Peninsula), consisting of 13 isolated teeth and a fragment of calcaneus, is studied in this work. These fossils allow the first description of the calcaneus and the upper premolars for the genus Agerinia, as well as the first description of the P2 and M(2) for A. smithorum. The newly recovered lower teeth are virtually identical to the holotype of A. smithorum and are clearly distinguishable from the other species of Agerinia...
December 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29054124/historical-demography-and-colonisation-pathways-of-the-widespread-intertidal-seaweed-hormosira-banksii-phaeophyceae-in-southeastern-australia
#7
Rebecca Mueller, Jeffrey T Wright, Christopher J S Bolch
The palaeoceanography of southern Australia has been characterized by fluctuating sea levels during glacial periods, changing temperature regimes and modified boundary currents. Previous studies on genetic structuring of species in southeastern Australia have focused mainly on the differentiation of eastern and western populations while the potential role of Bass Strait as a region of overlap for three biogeographic provinces (Peronia, Maugea, and Flindersia) has been largely ignored. This study aimed to explore the likely roles of historic and contemporary factors in determining divergence patterns in the habitat-forming intertidal seaweed Hormosira banksii in southeastern Australia with a special focus on postglacial dispersal into Bass Strait...
October 20, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/29054024/social-skills-plus-relaxation-training-with-a-child-with-asd-in-the-schools
#8
Margaret T Floress, Kim Zoder-Martell, Rachel Schaub
A social skills plus relaxation training (SSRT) program was developed using direct training, relaxation training, and reinforcement principles. The aim was to examine the effectiveness of SSRT on increasing the frequency of three target behaviors for one 8-year-old, student classified with autism spectrum disorder (ASD). A multiple-baseline across behaviors design was used to evaluate the effects of SSRT. During baseline, intervention, and maintenance sessions the student's responses were videotaped and then subsequently viewed and coded after the session...
October 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29054012/the-role-of-long-noncoding-rnas-in-cancer-the-dark-matter-matters
#9
REVIEW
Xiaowen Hu, Anil K Sood, Chi V Dang, Lin Zhang
Sequencing technology has facilitated a new era of cancer research, especially in cancer genomics. Using next-generation sequencing, thousands of long noncoding RNAs (lncRNAs) have been identified as abnormally altered in the cancer genome or differentially expressed in tumor tissues. These lncRNAs are associated with imbalanced gene regulation and aberrant biological processes that contribute to malignant transformation. The functions and therapeutic potential of cancer-related lncRNAs have attracted considerable interest in the past few years...
October 17, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29053746/external-auditory-exostoses-and-hearing-loss-in-the-shanidar-1-neandertal
#10
Erik Trinkaus, Sébastien Villotte
The Late Pleistocene Shanidar 1 older adult male Neandertal is known for the crushing fracture of his left orbit with a probable reduction in vision, the loss of his right forearm and hand, and evidence of an abnormal gait, as well as probable diffuse idiopathic skeletal hyperostosis. He also exhibits advanced external auditory exostoses in his left auditory meatus and larger ones with complete bridging across the porus in the right meatus (both Grade 3). These growths indicate at least unilateral conductive hearing (CHL) loss, a serious sensory deprivation for a Pleistocene hunter-gatherer...
2017: PloS One
https://www.readbyqxmd.com/read/29053698/simultaneous-multi-surface-anodizations-and-stair-like-reverse-biases-detachment-of-anodic-aluminum-oxides-in-sulfuric-and-oxalic-acid-electrolyte
#11
Healin Im, Seok Hwan Jeong, Dong Hyuk Park, Sunkook Kim, Young Ki Hong
After reporting on the two-step anodization, nanoporous anodic aluminum oxides (AAOs) have been widely utilized in the versatile fields of fundamental sciences and industrial applications owing to their periodic arrangement of nanopores with relatively high aspect ratio. However, the techniques reported so far, which could be only valid for mono-surface anodization, show critical disadvantages, i.e., time-consuming as well as complicated procedures, requiring toxic chemicals, and wasting valuable natural resources...
October 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053681/a-performance-testing-platform-for-a-conduction-micropump-with-an-fr-4-copper-clad-electrode-plate
#12
Junyuan Feng, Zhenping Wan, Chen Feng, Wanyu Wen, Yong Tang
Here, a conduction micropump with symmetric planar electrode pairs prepared on flame-retardant glass-reinforced epoxy (FR-4) copper-clad laminate (CCL) is fabricated. It is used to investigate the influence of chamber dimensions on the performance of a conduction micropump and to determine the reliability of the conduction pump when acetone is used as the working fluid. A testing platform is set up to evaluate conduction micropump performance under different conditions. When the chamber height is 0.2 mm, the pump pressure reaches its peak value...
October 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053614/crack-monitoring-method-for-an-frp-strengthened-steel-structure-based-on-an-antenna-sensor
#13
Zhiping Liu, Kai Chen, Zongchen Li, Xiaoli Jiang
Fiber-reinforced polymer (FRP) has been increasingly applied to steel structures for structural strengthening or crack repair, given its high strength-to-weight ratio and high stiffness-to-weight ratio. Cracks in steel structures are the dominant hidden threats to structural safety. However, it is difficult to monitor structural cracks under FRP coverage and there is little related research. In this paper, a crack monitoring method for an FRP-strengthened steel structure deploying a microstrip antenna sensor is presented...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053415/low-concentration-of-5-fluorouracil-increases-the-effectiveness-of-tumor-rna-to-activate-murine-dendritic-cells
#14
Marcela Rodrigues de Camargo, Carolina Mendonça Gorgulho, Cecília Pessoa Rodrigues, Marcimara Penitenti, Juliana Cristina Longo Frederico, Maria Aparecida Marchesan Rodrigues, Ramon Kaneno
AIM: Considering the central role of dendritic cells (DCs) on the development of an antitumor immune response, in this study we used a murine model to evaluate how DC transfection with drug-treated tumor cell RNA changes their phenotype, and whether transfection enhances the in vivo effectiveness of a DC-based antitumor vaccine. MATERIALS AND METHODS: MC-38 colorectal tumor cells were pretreated with the minimum effective concentration of 5-fluorouracil (5-FU), then their total RNA was extracted and transfected into DCs...
October 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29053374/pedestrian-crossing-behavior-an-observational-study-in-the-city-of-ushuaia-argentina
#15
Fernando Martín Poó, Ruben Daniel Ledesma, Roberto Trujillo
OBJECTIVES: Pedestrian crashes are a critical problem in Latin American countries. However, little research has been published about pedestrians and even less about their behaviors in a naturalistic context. The objective of the present research was to explore risky pedestrian crossing behaviors in traffic intersections in an argentine city (Ushuaia). It is focused in different stages of the crossing process, traffic code violations, and other potentially risky behaviors such as distractions...
October 20, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29053283/localization-transition-induced-by-learning-in-random-searches
#16
Andrea Falcón-Cortés, Denis Boyer, Luca Giuggioli, Satya N Majumdar
We solve an adaptive search model where a random walker or Lévy flight stochastically resets to previously visited sites on a d-dimensional lattice containing one trapping site. Because of reinforcement, a phase transition occurs when the resetting rate crosses a threshold above which nondiffusive stationary states emerge, localized around the inhomogeneity. The threshold depends on the trapping strength and on the walker's return probability in the memoryless case. The transition belongs to the same class as the self-consistent theory of Anderson localization...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053052/effect-of-laser-etching-on-glass-fiber-posts-cemented-with-different-adhesive-systems
#17
Ozge Parlar Oz, Asli Secilmis, Cemal Aydin
BACKGROUND: Glass fiber-reinforced posts have been preferred frequently because of some physical properties similar to the dentin, chemically bonding to dentin, biocompatibility, and esthetics. OBJECTIVE: This study aimed to evaluate the microleakage and bond strength of glass fiber posts cemented with various adhesive systems on laser-etched root canal walls. METHODS: Roots of 120 human mandibular premolars were divided into two groups for push-out bond strength test and the microleakage test (n = 60)...
October 19, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29052960/treatment-and-outcomes-of-melanoma-in-asia-results-from-the-national-cancer-centre-singapore
#18
Yi Lin Teh, Wei Lin Goh, Sze Huey Tan, Grace Yong, Alisa Noor Hidayah Sairi, Khee Chee Soo, Johnny Ong, Claramae Chia, Grace Tan, Henry Soeharno, Mann Hong Tan, Michelle Chan, Selvarajan Sathiyamoorthy, Kesavan Sittampalam, Jonathan Teh, Francis Chin, Vijay Sethi, Melissa Teo, Richard Quek, Mohamad Farid
BACKGROUND: Acral melanoma (AM) and mucosal melanoma (MM) make up more than half of melanomas in Asia but comprise only 5% of cases in Caucasians, where cutaneous melanoma (CM) predominates. AM and MM are thought to be genetically and biologically distinct from CM. We report the characteristics and outcomes of melanoma patients from the National Cancer Centre Singapore. METHODS: Case records of 210 patients treated between 2002 and 2014 were reviewed. RESULTS: Median follow-up was 2...
October 20, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29052942/genealogies-of-recovery-the-framing-of-therapeutic-ambitions
#19
Brian Brown, Nick Manning
The notion of recovery has become prominent in mental healthcare discourse in the UK, but it is often considered as if it were a relatively novel notion, and as if it represented an alternative to conventional treatment and intervention. In this paper, we explore some of the origins of the notion of recovery in the early 20th century in movements such as Alcoholics Anonymous and Recovery Inc. Whilst these phenomena are not entirely continuous with recovery in the present day, some important antecedents of the contemporary notion can be detected...
October 20, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/29052910/cell-proliferation-is-associated-with-intensity-of-tumor-budding-in-oral-squamous-cell-carcinoma
#20
Helvécio Marangon Junior, Priscila Laiza Rubim Leão, Victória Vasconcellos Moreira Melo, Ângela Braga Caixeta, Paulo Eduardo Alencar Souza, Maria Cássia Ferreira de Aguiar, Martinho Campolina Rebello Horta
BACKGROUND: Tumor budding is a morphological marker of cancer invasion, defined as the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. This study aimed to evaluate the association between intensity of tumor budding and cell proliferation in oral squamous cell carcinoma (OSCC). METHODS: Immunohistochemistry was employed in 163 OSCC samples to detect the cell proliferation marker Ki-67 and multi-cytokeratin (to identify OSCC cells in tumor budding evaluation)...
October 20, 2017: Journal of Oral Pathology & Medicine
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