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Cannabis cancer

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https://www.readbyqxmd.com/read/27848262/bioactive-spirans-and-other-constituents-from-the-leaves-of-cannabis-sativa-f-sativa
#1
Tian-Tian Guo, Jian-Chun Zhang, Hai Zhang, Qing-Chao Liu, Yong Zhao, Yu-Fei Hou, Lu Bai, Li Zhang, Xue-Qiang Liu, Xue-Ying Liu, Sheng-Yong Zhang, Nai-Sheng Bai
In this paper, 17 compounds (1-17) were isolated from the leaves of Hemp (Cannabis sativa f. sativa). Among the isolates, two were determined to be new spirans: cannabispirketal (1), and α-cannabispiranol 4'-O-β-D-glucopyranose (2) by 1D and 2D NMR spectroscopy, LC-MS, and HRESIMS. The known compounds 7, 8, 10, 13, 15, and 16 were isolated from Hemp (C. sativa f. sativa) for the first time. Furthermore, compounds 8 and 13 were isolated from the nature for the first time. All isolated compounds were evaluated for cytotoxicity on different tissue-derived passage cancer cell lines through cell viability and apoptosis assay...
November 16, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27821713/quantitative-analyses-of-synergistic-responses-between-cannabidiol-and-dna-damaging-agents-on-the-proliferation-and-viability-of-glioblastoma-and-neural-progenitor-cells-in-culture
#2
Liting Deng, Lindsay Ng, Tatsuya Ozawa, Nephi Stella
Evidence suggests that the non-psychotropic cannabis-derived compound, cannabidiol (CBD), has anti-neoplastic activity in multiple types of cancers, including glioblastoma multiforme (GBM). DNA-damaging agents remain the main standard of care treatment available for patients diagnosed with GBM. Here we studied the anti-proliferative and cell-killing activity of CBD alone and in combination with DNA-damaging agents (temozolomide, carmustine or cisplatin) in several human GBM cell lines and in mouse primary GBM cells in cultures...
November 7, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27802436/win-55-212-2-inhibits-the-epithelial-mesenchymal-transition-of-gastric-cancer-cells-via-cox-2-signals
#3
Xiangshu Xian, Liuye Huang, Bo Zhang, Chengrong Wu, Jun Cui, Zhihua Wang
BACKGROUND: Cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to reports that they can affect the tumor growth, migration, and metastasis. Previous studies showed that the cannabinoid agonist WIN 55,212-2 (WIN) was associated with gastric cancer (GC) metastasis, but the mechanisms were unknown. METHODS: The effects of WIN on GC cell migration and invasion were analyzed by the wound-healing assay and Transwell assay...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27789118/adverse-structural-and-functional-effects-of-marijuana-on-the-brain-evidence-reviewed
#4
REVIEW
David E Mandelbaum, Suzanne M de la Monte
The growing use and legalization of cannabis are leading to increased exposures across all age groups, including in adolescence. The touting of its medicinal values stems from anecdotal reports related to treatment of a broad range of illnesses including epilepsy, multiple sclerosis, muscle spasms, arthritis, obesity, cancer, Alzheimer disease, Parkinson disease, post-traumatic stress, inflammatory bowel disease, and anxiety. However, it is essential that anecdotal data and the high level of interest in this treatment not obscure objective assessments of any potential and realized short- and long-term adverse effects of cannabis, particularly with respect to age of onset and chronicity of exposure...
September 13, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27757048/medical-cannabis-the-canadian-perspective
#5
Gordon D Ko, Sara L Bober, Sean Mindra, Jason M Moreau
Cannabis has been widely used as a medicinal agent in Eastern medicine with earliest evidence in ancient Chinese practice dating back to 2700 BC. Over time, the use of medical cannabis has been increasingly adopted by Western medicine and is thus a rapidly emerging field that all pain physicians need to be aware of. Several randomized controlled trials have shown a significant and dose-dependent relationship between neuropathic pain relief and tetrahydrocannabinol - the principal psychoactive component of cannabis...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27680736/the-grass-isn-t-always-greener-the-effects-of-cannabis-on-embryological-development
#6
Joseph Friedrich, Dara Khatib, Keon Parsa, Ariana Santopietro, G Ian Gallicano
With the increasing publicity of marijuana due to recent legislation, it is pertinent that the effects of fetal exposure to the drug are assessed. While in utero cannabis exposure has been associated with early pregnancy failure, birth defects and developmental delay, the mechanisms of such outcomes are largely unexplained. Furthermore, the use of cannabinoids in cancer treatment via growth inhibition and apoptosis may indicate how cannabis exposure likely harms a growing fetus. Cannabinoid signaling is required for proper pre-implantation development, embryo transport to the uterus, and uterine receptivity during implantation...
September 29, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27621706/evaluation-of-two-commercially-available-cannabidiol-formulations-for-use-in-electronic-cigarettes
#7
Michelle R Peace, Karen E Butler, Carl E Wolf, Justin L Poklis, Alphonse Poklis
Since 24 states and the District of Columbia have legalized marijuana in some form, suppliers of legal marijuana have developed Cannabis sativa products for use in electronic cigarettes (e-cigarettes). Personal battery powered vaporizers, or e-cigarettes, were developed to deliver a nicotine vapor such that smokers could simulate smoking tobacco without the inherent pathology of inhaled tobacco smoke. The liquid formulations used in these devices are comprised of an active ingredient such as nicotine mixed with vegetable glycerin (VG) and/or propylene glycol (PG) and flavorings...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27586579/cannabidiol-rather-than-cannabis-sativa-extracts-inhibit-cell-growth-and-induce-apoptosis-in-cervical-cancer-cells
#8
Sindiswa T Lukhele, Lesetja R Motadi
BACKGROUND: Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in various regions of Africa, however, over a quarter of a million women die of cervical cancer, annually. This makes it the most lethal cancer amongst black women and calls for urgent therapeutic strategies. In this study we compare the anti-proliferative effects of crude extract of Cannabis sativa and its main compound cannabidiol on different cervical cancer cell lines...
September 1, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27573646/damaging-effects-of-cannabis-use-on-the-lungs
#9
Josef Yayan, Kurt Rasche
Cannabis is the most widely smoked illicit substance in the world. It can be smoked alone in its plant form, marijuana, but it can also be mixed with tobacco. The specific effects of smoking cannabis are difficult to assess accurately and to distinguish from the effects of tobacco; however its use may produce severe consequences. Cannabis smoke affects the lungs similarly to tobacco smoke, causing symptoms such as increased cough, sputum, and hyperinflation. It can also cause serious lung diseases with increasing years of use...
August 30, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27561826/the-gastrointestinal-tract-a-central-organ-of-cannabinoid-signaling-in-health-and-disease
#10
REVIEW
C Hasenoehrl, U Taschler, M Storr, R Schicho
BACKGROUND: In ancient medicine, extracts of the marijuana plant Cannabis sativa were used against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of the Cannabis plant has remarkably advanced enabling us to use a variety of herbal and synthetic cannabinoid (CB) compounds to study the endocannabinoid system (ECS), a physiologic entity that controls tissue homeostasis with the help of endogenously produced CBs and their receptors. After many anecdotal reports suggested beneficial effects of Cannabis in GI disorders, it was not surprising to discover that the GI tract accommodates and expresses all the components of the ECS...
December 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27530738/clinical-trials-of-medicinal-cannabis-for-appetite-related-symptoms-from-advanced-cancer-a-survey-of-preferences-attitudes-and-beliefs-among-patients-willing-to-consider-participation
#11
Tim Luckett, Jane Phillips, Nicholas Lintzeris, David Allsop, Jessica Lee, Nadia Solowij, Jennifer Martin, Lawrence Lam, Rajesh Aggarwal, Nicola McCaffrey, David Currow, Richard Chye, Melanie Lovell, Iain McGregor, Meera Agar
BACKGROUND: Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts. AIMS: To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite-related symptoms from advanced cancer. METHODS: A cross-sectional anonymous survey was administered from July to December 2015 in 8 adult outpatient palliative care and/or cancer services, and online...
August 17, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27530354/cannabidiolic-acid-mediated-selective-down-regulation-of-c-fos-in-highly-aggressive-breast-cancer-mda-mb-231-cells-possible-involvement-of-its-down-regulation-in-the-abrogation-of-aggressiveness
#12
Shuso Takeda, Taichi Himeno, Kazuhiro Kakizoe, Hiroyuki Okazaki, Tomoko Okada, Kazuhito Watanabe, Hironori Aramaki
The physiological activities of cannabidiolic acid (CBDA), a component of fiber-type cannabis plants, have been demonstrated and include its function as a protector against external invasion by inducing cannabinoid-mediated necrosis (Shoyama et al., Plant Signal Behav 3:1111-1112, 2008). The biological activities of CBDA have been attracting increasing attention. We previously identified CBDA as an inhibitor of the migration of MDA-MB-231 cells, a widely used human breast cancer cell line in cancer biology, due to its highly aggressive nature...
August 16, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27420392/storage-and-disposal-of-medical-cannabis-among-patients-with-cancer-assessing-the-risk-of-diversion-and-unintentional-digestion
#13
Sharon R Sznitman, Victoria Goldberg, Hedva Sheinman-Yuffe, Ezequiel Flechter, Gil Bar-Sela
BACKGROUND: Increasingly more jurisdictions worldwide are legalizing medical cannabis. Major concerns related to such policies are that improper storage and disposal arrangements may lead to the diversion and unintentional digestion of cannabis. These concerns are particularly acute among patients with cancer because they take home medical cannabis for extended periods and have high rates of treatment termination and mortality shortly after the onset of treatment with medical cannabis...
July 15, 2016: Cancer
https://www.readbyqxmd.com/read/27334611/cannabimimetic-drugs-recent-patents-in-central-nervous-system-disorders
#14
Roberta Ranieri, Daniela Marasco, Maurizio Bifulco, Anna Maria Malfitano
Agents acting via cannabinoid receptors have been widely developed; starting from the chemical structure of phytocannabinoids isolated from cannabis sativa plant, specific and selective compounds of these receptors have been produced ranging from partial to full agonists and /or antagonists endowed with different potency. The enhanced interest on developing such classes of drugs is due to the beneficial properties widely reported by both anecdotal reports and scientific studies describing the potential medicinal use of cannabinoids and their derivatives in numerous pathological conditions in both in vitro and in vivo models...
June 19, 2016: Recent Patents on CNS Drug Discovery
https://www.readbyqxmd.com/read/27208973/chromothripsis-and-epigenomics-complete-causality-criteria-for-cannabis-and-addiction-connected-carcinogenicity-congenital-toxicity-and-heritable-genotoxicity
#15
REVIEW
Albert Stuart Reece, Gary Kenneth Hulse
The recent demonstration that massive scale chromosomal shattering or pulverization can occur abruptly due to errors induced by interference with the microtubule machinery of the mitotic spindle followed by haphazard chromosomal annealing, together with sophisticated insights from epigenetics, provide profound mechanistic insights into some of the most perplexing classical observations of addiction medicine, including cancerogenesis, the younger and aggressive onset of addiction-related carcinogenesis, the heritability of addictive neurocircuitry and cancers, and foetal malformations...
July 2016: Mutation Research
https://www.readbyqxmd.com/read/27184693/phytocannabinoids-and-cannabimimetic-drugs-recent-patents-in-central-nervous-system-disorders
#16
Roberta Ranieri, Daniela Marasco, Maurizio Bifulco, Anna Maria Malfitano
BACKGROUND: Starting from the chemical structure of phytocannabinoids, isolated from Cannabis sativa plant, research groups designed numerous cannabimimetic drugs. These compounds according to their activities can be partial, full agonists and antagonists of cannabinoid receptors. Anecdotal reports and scientific studies described beneficial properties of cannabinoids and their derivatives in several pathological conditions like neurological and neuropsychiatric disorders, and in many other diseases ranging from cancer, atherosclerosis, stroke, hypertension, inflammatory related disorders, and autoimmune diseases...
May 17, 2016: Recent Patents on CNS Drug Discovery
https://www.readbyqxmd.com/read/27086601/endocannabinoid-system-a-multi-facet-therapeutic-target
#17
REVIEW
Rimplejeet Kaur, Sneha R Ambwani, Surjit Singh
Cannabis sativa is also popularly known as marijuana. It has been cultivated and used by man for recreational and medicinal purposes since many centuries. Study of cannabinoids was at bay for very long time and its therapeutic value could not be adequately harnessed due to its legal status as proscribed drug in most of the countries. The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve "protective role" in many medical conditions...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27022315/integrating-cannabis-into-clinical-cancer-care
#18
D I Abrams
Cannabis species have been used as medicine for thousands of years; only since the 1940s has the plant not been widely available for medical use. However, an increasing number of jurisdictions are making it possible for patients to obtain the botanical for medicinal use. For the cancer patient, cannabis has a number of potential benefits, especially in the management of symptoms. Cannabis is useful in combatting anorexia, chemotherapy-induced nausea and vomiting, pain, insomnia, and depression. Cannabis might be less potent than other available antiemetics, but for some patients, it is the only agent that works, and it is the only antiemetic that also increases appetite...
March 2016: Current Oncology
https://www.readbyqxmd.com/read/27022313/cannabis-and-cancer-toward-a-new-understanding
#19
M A Ware
No abstract text is available yet for this article.
March 2016: Current Oncology
https://www.readbyqxmd.com/read/27022310/in-vitro-and-in-vivo-efficacy-of-non-psychoactive-cannabidiol-in-neuroblastoma
#20
T Fisher, H Golan, G Schiby, S PriChen, R Smoum, I Moshe, N Peshes-Yaloz, A Castiel, D Waldman, R Gallily, R Mechoulam, A Toren
BACKGROUND: Neuroblastoma (nbl) is one of the most common solid cancers in children. Prognosis in advanced nbl is still poor despite aggressive multimodality therapy. Furthermore, survivors experience severe long-term multi-organ sequelae. Hence, the identification of new therapeutic strategies is of utmost importance. Cannabinoids and their derivatives have been used for years in folk medicine and later in the field of palliative care. Recently, they were found to show pharmacologic activity in cancer, including cytostatic, apoptotic, and antiangiogenic effects...
March 2016: Current Oncology
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