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Cannabis cancer

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https://www.readbyqxmd.com/read/28340421/cannabis-use-patterns-and-motives-a-comparison-of-younger-middle-aged-and-older-medical-cannabis-dispensary-patients
#1
Nancy A Haug, Claudia B Padula, James E Sottile, Ryan Vandrey, Adrienne J Heinz, Marcel O Bonn-Miller
INTRODUCTION: Medical cannabis is increasingly being used for a variety of health conditions as more states implement legislation permitting medical use of cannabis. Little is known about medical cannabis use patterns and motives among adults across the lifespan. METHODS: The present study examined data collected at a medical cannabis dispensary in San Francisco, California. Participants included 217 medical cannabis patients who were grouped into age-defined cohorts (younger: 18-30, middle-aged: 31-50, and older: 51-72)...
March 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28274851/emerging-therapeutic-targets-in-cancer-induced-bone-disease-a-focus-on-the-peripheral-type-2-cannabinoid-receptor
#2
REVIEW
Silvia Marino, Aymen I Idris
Skeletal complications are a common cause of morbidity in patients with primary bone cancer and bone metastases. The type 2 cannabinoid (Cnr2) receptor is implicated in cancer, bone metabolism and pain perception. Emerging data have uncovered the role of Cnr2 in the regulation of tumour-bone cell interactions and suggest that agents that target Cnr2 in the skeleton have potential efficacy in the reduction of skeletal complications associated with cancer. This review aims to provide an overview of findings relating to the role of Cnr2 receptor in the regulation of skeletal tumour growth, osteolysis and bone pain, and highlights the many unanswered questions and unmet needs...
March 6, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28263690/psychiatric-complications-of-cannabis-oil-use-in-cancer-patients-whose-responsibility-is-it-to-manage
#3
Raymond C Parrish, Hermioni N Lokko, David P Yuppa, Ilana M Braun, Fremonta L Meyer
No abstract text is available yet for this article.
March 6, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28250664/potential-of-cannabidiol-for-the-treatment-of-viral-hepatitis
#4
Henry I C Lowe, Ngeh J Toyang, Wayne McLaughlin
Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. While HBV has a vaccine, HCV has none at the moment. The risk of drug resistance, combined with the high cost of current therapies, makes it a necessity for cost-effective therapeutics to be discovered and developed. The recent surge in interest in Medical Cannabis has led to interest in evaluating and validating the therapeutic potentials of Cannabis and its metabolites against various diseases including viruses...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28174520/modulation-of-human-peripheral-blood-mononuclear-cell-signaling-by-medicinal-cannabinoids
#5
Wesley K Utomo, Marjan de Vries, Henri Braat, Marco J Bruno, Kaushal Parikh, Mònica Comalada, Maikel P Peppelenbosch, Harry van Goor, Gwenny M Fuhler
Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory properties of medical cannabis. Healthy volunteers were asked to ingest medical cannabis, and kinome profiling was used to generate comprehensive descriptions of the cannabis challenge on inflammatory signal transduction in the peripheral blood of these volunteers...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28120229/phytochemistry-of-cannabis-sativa-l
#6
Mahmoud A ElSohly, Mohamed M Radwan, Waseem Gul, Suman Chandra, Ahmed Galal
Cannabis (Cannabis sativa, or hemp) and its constituents-in particular the cannabinoids-have been the focus of extensive chemical and biological research for almost half a century since the discovery of the chemical structure of its major active constituent, Δ(9)-tetrahydrocannabinol (Δ(9)-THC). The plant's behavioral and psychotropic effects are attributed to its content of this class of compounds, the cannabinoids, primarily Δ(9)-THC, which is produced mainly in the leaves and flower buds of the plant...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28120116/urine-drug-screen-findings-among-ambulatory-oncology-patients-in-a-supportive-care-clinic
#7
Sherri Rauenzahn, Adam Sima, Brian Cassel, Danielle Noreika, Teny Henry Gomez, Lynn Ryan, Carl E Wolf, Luke Legakis, Egidio Del Fabbro
PURPOSE: Professional organizations provide no guidelines regarding assessment and management of opioid abuse risk in cancer. Universal precautions (UP) developed for non-cancer pain, include assessments for aberrant behavior, screening questionnaires, and urine drug screens (UDS). The role of UDS for identifying opioid abuse risk in cancer is uncertain. Our aim is to characterize inappropriate UDS, and identify a potential role for UDS in therapeutic decision-making. METHODS: An observational retrospective chart review of 232 consecutive supportive care clinic patients were seen during the study...
January 25, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28100841/cannabinoids-a-new-weapon-against-cancer
#8
Małgorzata Pokrywka, Joanna Góralska, Bogdan Solnica
Cannabis has been cultivated by man since Neolithic times. It was used, among others for fiber and rope production, recreational purposes and as an excellent therapeutic agent. The isolation and characterization of the structure of one of the main active ingredients of cannabis - Δ9 - tetrahydrocannabinol as well the discovery of its cannabinoid binding receptors CB1 and CB2, has been a milestone in the study of the possibilities of the uses of Cannabis sativa and related products in modern medicine. Many scientific studies indicate the potential use of cannabinoids in the fight against cancer...
December 29, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28077504/influence-of-history-of-cannabis-smoking-in-selected-donors-on-the-outcomes-of-lung-transplantation
#9
Prashant N Mohite, Mohamed Zeriouh, Diana G Sáez, Aron-Frederik Popov, Anton Sabashnikov, Bartlomiej Zych, Ashok Padukone, Levente Fazekas, Olga Ananiadou, Fabio De Robertis, Simona Soresi, Anna Reed, Martin Carby, André R Simon
OBJECTIVES: Cannabis is the most commonly abused illicit drug and the smokers are at the risk of lung infections, bullous emphysema and lung cancer. However, no evidence about the outcomes of lung transplantation (LTx) utilizing the lungs from such donors is available in the literature. METHODS: We retrospectively analysed lung 'organ offers' and LTx at our centre between January 2007 and November 2013. The outcomes of LTx utilizing lungs from donors with a history of cannabis smoking were compared with the outcomes of those with no such history using unadjusted model as well as propensity score matching...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27848262/bioactive-spirans-and-other-constituents-from-the-leaves-of-cannabis-sativa-f-sativa
#10
Tian-Tian Guo, Jian-Chun Zhang, Hai Zhang, Qing-Chao Liu, Yong Zhao, Yu-Fei Hou, Lu Bai, Li Zhang, Xue-Qiang Liu, Xue-Ying Liu, Sheng-Yong Zhang, Nai-Sheng Bai
In this paper, 17 compounds (1-17) were isolated from the leaves of Hemp (Cannabis sativa f. sativa). Among the isolates, two were determined to be new spirans: cannabispirketal (1), and α-cannabispiranol 4'-O-β-D-glucopyranose (2) by 1D and 2D NMR spectroscopy, LC-MS, and HRESIMS. The known compounds 7, 8, 10, 13, 15, and 16 were isolated from Hemp (C. sativa f. sativa) for the first time. Furthermore, compounds 8 and 13 were isolated from the nature for the first time. All isolated compounds were evaluated for cytotoxicity on different tissue-derived passage cancer cell lines through cell viability and apoptosis assay...
November 16, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27821713/quantitative-analyses-of-synergistic-responses-between-cannabidiol-and-dna-damaging-agents-on-the-proliferation-and-viability-of-glioblastoma-and-neural-progenitor-cells-in-culture
#11
Liting Deng, Lindsay Ng, Tatsuya Ozawa, Nephi Stella
Evidence suggests that the nonpsychotropic cannabis-derived compound, cannabidiol (CBD), has antineoplastic activity in multiple types of cancers, including glioblastoma multiforme (GBM). DNA-damaging agents remain the main standard of care treatment available for patients diagnosed with GBM. Here we studied the antiproliferative and cell-killing activity of CBD alone and in combination with DNA-damaging agents (temozolomide, carmustine, or cisplatin) in several human GBM cell lines and in mouse primary GBM cells in cultures...
January 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27802436/win-55-212-2-inhibits-the-epithelial-mesenchymal-transition-of-gastric-cancer-cells-via-cox-2-signals
#12
Xiangshu Xian, Liuye Huang, Bo Zhang, Chengrong Wu, Jun Cui, Zhihua Wang
BACKGROUND: Cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to reports that they can affect the tumor growth, migration, and metastasis. Previous studies showed that the cannabinoid agonist WIN 55,212-2 (WIN) was associated with gastric cancer (GC) metastasis, but the mechanisms were unknown. METHODS: The effects of WIN on GC cell migration and invasion were analyzed by the wound-healing assay and Transwell assay...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27789118/adverse-structural-and-functional-effects-of-marijuana-on-the-brain-evidence-reviewed
#13
REVIEW
David E Mandelbaum, Suzanne M de la Monte
The growing use and legalization of cannabis are leading to increased exposures across all age groups, including in adolescence. The touting of its medicinal values stems from anecdotal reports related to treatment of a broad range of illnesses including epilepsy, multiple sclerosis, muscle spasms, arthritis, obesity, cancer, Alzheimer disease, Parkinson disease, post-traumatic stress, inflammatory bowel disease, and anxiety. However, anecdotal data and the high level of interest in this treatment must not obscure objective assessments of any potential and realized short- and long-term adverse effects of cannabis, particularly with respect to age of onset and chronicity of exposure...
January 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/27757048/medical-cannabis-the-canadian-perspective
#14
REVIEW
Gordon D Ko, Sara L Bober, Sean Mindra, Jason M Moreau
Cannabis has been widely used as a medicinal agent in Eastern medicine with earliest evidence in ancient Chinese practice dating back to 2700 BC. Over time, the use of medical cannabis has been increasingly adopted by Western medicine and is thus a rapidly emerging field that all pain physicians need to be aware of. Several randomized controlled trials have shown a significant and dose-dependent relationship between neuropathic pain relief and tetrahydrocannabinol - the principal psychoactive component of cannabis...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27680736/the-grass-isn-t-always-greener-the-effects-of-cannabis-on-embryological-development
#15
REVIEW
Joseph Friedrich, Dara Khatib, Keon Parsa, Ariana Santopietro, G Ian Gallicano
With the increasing publicity of marijuana due to recent legislation, it is pertinent that the effects of fetal exposure to the drug are assessed. While in utero cannabis exposure has been associated with early pregnancy failure, birth defects and developmental delay, the mechanisms of such outcomes are largely unexplained. Furthermore, the use of cannabinoids in cancer treatment via growth inhibition and apoptosis may indicate how cannabis exposure likely harms a growing fetus. Cannabinoid signaling is required for proper pre-implantation development, embryo transport to the uterus, and uterine receptivity during implantation...
September 29, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27621706/evaluation-of-two-commercially-available-cannabidiol-formulations-for-use-in-electronic-cigarettes
#16
Michelle R Peace, Karen E Butler, Carl E Wolf, Justin L Poklis, Alphonse Poklis
Since 24 states and the District of Columbia have legalized marijuana in some form, suppliers of legal marijuana have developed Cannabis sativa products for use in electronic cigarettes (e-cigarettes). Personal battery powered vaporizers, or e-cigarettes, were developed to deliver a nicotine vapor such that smokers could simulate smoking tobacco without the inherent pathology of inhaled tobacco smoke. The liquid formulations used in these devices are comprised of an active ingredient such as nicotine mixed with vegetable glycerin (VG) and/or propylene glycol (PG) and flavorings...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27586579/cannabidiol-rather-than-cannabis-sativa-extracts-inhibit-cell-growth-and-induce-apoptosis-in-cervical-cancer-cells
#17
Sindiswa T Lukhele, Lesetja R Motadi
BACKGROUND: Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in various regions of Africa, however, over a quarter of a million women die of cervical cancer, annually. This makes it the most lethal cancer amongst black women and calls for urgent therapeutic strategies. In this study we compare the anti-proliferative effects of crude extract of Cannabis sativa and its main compound cannabidiol on different cervical cancer cell lines...
September 1, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27573646/damaging-effects-of-cannabis-use-on-the-lungs
#18
Josef Yayan, Kurt Rasche
Cannabis is the most widely smoked illicit substance in the world. It can be smoked alone in its plant form, marijuana, but it can also be mixed with tobacco. The specific effects of smoking cannabis are difficult to assess accurately and to distinguish from the effects of tobacco; however its use may produce severe consequences. Cannabis smoke affects the lungs similarly to tobacco smoke, causing symptoms such as increased cough, sputum, and hyperinflation. It can also cause serious lung diseases with increasing years of use...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27561826/the-gastrointestinal-tract-a-central-organ-of-cannabinoid-signaling-in-health-and-disease
#19
REVIEW
C Hasenoehrl, U Taschler, M Storr, R Schicho
BACKGROUND: In ancient medicine, extracts of the marijuana plant Cannabis sativa were used against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of the Cannabis plant has remarkably advanced enabling us to use a variety of herbal and synthetic cannabinoid (CB) compounds to study the endocannabinoid system (ECS), a physiologic entity that controls tissue homeostasis with the help of endogenously produced CBs and their receptors. After many anecdotal reports suggested beneficial effects of Cannabis in GI disorders, it was not surprising to discover that the GI tract accommodates and expresses all the components of the ECS...
December 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27530738/clinical-trials-of-medicinal-cannabis-for-appetite-related-symptoms-from-advanced-cancer-a-survey-of-preferences-attitudes-and-beliefs-among-patients-willing-to-consider-participation
#20
T Luckett, J Phillips, N Lintzeris, D Allsop, J Lee, N Solowij, J Martin, L Lam, R Aggarwal, N McCaffrey, D Currow, R Chye, M Lovell, I McGregor, M Agar
BACKGROUND: Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts. AIMS: To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite-related symptoms from advanced cancer. METHODS: A cross-sectional anonymous survey was administered from July to December 2015 online and in eight adult outpatient palliative care and/or cancer services...
November 2016: Internal Medicine Journal
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