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https://www.readbyqxmd.com/read/29677540/ameliorating-effect-of-berbamine-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-and-streptozotocin-induced-type-2-diabetic-rats
#1
Sankaranarayanan Chandrasekaran, Nishanthi Ramajayam, Pugalendi Pachaiappan
BACKGROUND: Aberrations in the activities of key enzymes of carbohydrate metabolism is well documented in diabetes mellitus. Previous studies have shown that active ingredients in the extracts of Berberis aristata exhibits diverse pharmacological activities in animal models. OBJECTIVE: The present study was undertaken to investigate whether berbamine (BBM), an alkaloid from the roots of Berberis aristata can ameliorate the altered activities of carbohydrate metabolic enzymes in high fat diet (HFD)/streptozotocin (STZ) induced diabetic rats...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677490/egfr-phosphorylated-platelet-isoform-of-phosphofructokinase-1-promotes-pi3k-activation
#2
Jong-Ho Lee, Rui Liu, Jing Li, Yugang Wang, Lin Tan, Xin-Jian Li, Xu Qian, Chuanbao Zhang, Yan Xia, Daqian Xu, Wei Guo, Zhiyong Ding, Linyong Du, Yanhua Zheng, Qianming Chen, Philip L Lorenzi, Gordon B Mills, Tao Jiang, Zhimin Lu
EGFR activates phosphatidylinositide 3-kinase (PI3K), but the mechanism underlying this activation is not completely understood. We demonstrated here that EGFR activation resulted in lysine acetyltransferase 5 (KAT5)-mediated K395 acetylation of the platelet isoform of phosphofructokinase 1 (PFKP) and subsequent translocation of PFKP to the plasma membrane, where the PFKP was phosphorylated at Y64 by EGFR. Phosphorylated PFKP binds to the N-terminal SH2 domain of p85α, which is distinct from binding of Gab1 to the C-terminal SH2 domain of p85α, and recruited p85α to the plasma membrane resulting in PI3K activation...
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29677105/the-chemical-composition-and-metabolic-effects-of-attalea-phalerata-nut-oil-in-hyperlipidemic-rats-induced-by-a-high-fructose-diet
#3
Débora da Silva Baldivia, Eliana Janet Sanjinez-Argandonã, Kátia Ávila Antunes, Izabel Cristina Freitas Moraes, Edson Lucas Dos Santos, Kely de Picoli Souza
The fatty acids found in nuts are important regulators of the metabolism. These acids are frequently associated with a reduction of serum cholesterol and body fat and a lower risk of developing cardiovascular disease. In this context, the aim of this study was to identify and quantify the nut oil fatty acids from Attalea phalerata and investigate their metabolic effects in rats with hyperlipidemia induced by a diet rich in fructose. Oleic and lauric acids were the major compounds found in the A. phalerata nut oil (APNO)...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29675004/the-fast-growing-brucella-suis-biovar-5-depends-on-phosphoenolpyruvate-carboxykinase-and-pyruvate-phosphate-dikinase-but-not-on-fbp-and-glpx-fructose-1-6-bisphosphatases-or-isocitrate-lyase-for-full-virulence-in-laboratory-models
#4
Amaia Zúñiga-Ripa, Thibault Barbier, Leticia Lázaro-Antón, María J de Miguel, Raquel Conde-Álvarez, Pilar M Muñoz, Jean J Letesson, Maite Iriarte, Ignacio Moriyón
Bacteria of the genus Brucella infect a range of vertebrates causing a worldwide extended zoonosis. The best-characterized brucellae infect domestic livestock, behaving as stealthy facultative intracellular parasites. This stealthiness depends on envelope molecules with reduced pathogen-associated molecular patterns, as revealed by the low lethality and ability to persist in mice of these bacteria. Infected cells are often engorged with brucellae without signs of distress, suggesting that stealthiness could also reflect an adaptation of the parasite metabolism to use local nutrients without harming the cell...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674390/consumption-of-sugars-sugary-foods-and-sugary-beverages-in-relation-to-adiposity-related-cancer-risk-in-the-framingham-offspring-cohort-1991-2013
#5
Nour Makarem, Elisa V Bandera, Yong Lin, Paul Jacques, Richard B Hayes, Niyati Parekh
BACKGROUND: Higher sugar consumption may increase cancer risk by promoting insulin-glucose dysregulation, oxidative stress, hormonal imbalances, and excess adiposity. This prospective study investigates the association between dietary sugars(fructose and sucrose) and sugary foods and beverages in relation to combined and site-specific (breast, prostate, colorectal) adiposity-associated cancers. METHODS: The analytic sample consisted of 3,184 adults, aged 26-84y, from the Framingham Offspring cohort...
April 19, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29674343/impacts-of-pre-and-postnatal-nutrition-on-glucagon-regulation-and-hepatic-signalling-in-sheep
#6
Bishnu Adhikari, Prabhat Khanal, Mette Olaf Nielsen
To evaluate the long-term impacts of early life nutritional manipulations on glucagon secretion and hepatic signalling, thirty-six twin pregnant ewes during their last trimester were exposed to NORM (fulfilling 100% of daily energy/protein requirements), HIGH (fulfilling 150/110% of daily energy/protein requirements) or LOW (50% of NORM) diets. Twin lambs were assigned after birth to a moderate (CONV) or high-carbohydrate-high-fat (HCHF) diet until six months. Then responses in plasma glucagon concentrations and glucagon ratios relative to previously reported values for insulin, glucose and lactate were determined after intravenous bolus injections of glucose or propionate (fed and 2-days fasting state)...
April 19, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29674185/associations-of-prenatal-and-child-sugar-intake-with-child-cognition
#7
Juliana F W Cohen, Sheryl L Rifas-Shiman, Jessica Young, Emily Oken
INTRODUCTION: Sugar consumption among Americans is above recommended limits, and excess sugar intake may influence cognition. The aim of this study was to examine associations of pregnancy and offspring sugar consumption (sucrose, fructose) with child cognition. Additionally, associations of maternal and child consumption of sugar-sweetened beverages (SSBs), other beverages (diet soda, juice), and fruit with child cognition were examined. METHODS: Among 1,234 mother-child pairs enrolled 1999-2002 in Project Viva, a pre-birth cohort, in 2017 diet was assessed during pregnancy and early childhood, and cognitive outcomes in early and mid-childhood (median ages 3...
April 9, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29670844/the-eeffect-of-metformin-combined-with-calcium-vitamin-d-3-against-diet-induced-nonalcoholic-fatty-liver-disease
#8
Sara Shojaei Zarghani, Samin Abbaszadeh, Mohammad Alizadeh, Maryam Rameshrad, Alireza Garjani, Hamid Soraya
Purpose: Metformin is one of the most popular drugs tested against nonalcoholic fatty liver disease (NAFLD). The present study aimed to investigate whether calcium-vitamin D3 cosupplementation will intensify the effect of metformin on the prevention of high-fat, high-fructose (HFFr) diet-induced hepatic steatosis. Methods: Male wistar rats (210±16 g) were assigned into the following seven groups: a Control group to receive a standard chow and six HFFr-fed groups to receive diets containing either normal (0...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670839/effects-of-postconditioning-with-fructose-on-arrhythmias-and-the-size-of-infarct-caused-by-global-ischemia-and-reperfusion-in-isolated-rat-heart
#9
Jila Haghi, Tahereh Eteraf-Oskouei, Moslem Najafi
Purpose: In the present study, postconditioning effect of fructose against ischemia/reperfusion (I/R)-induced arrhythmias and infarct size were investigated in isolated rat heart. Methods: The isolated hearts were divided into 7 groups, mounted on a Langendorff apparatus at constant pressure then subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, normal Krebs-Henseleit (K/H) solution was perfused into the hearts throughout the experiment. In two separate sets of experiments, the treatment groups received 12, 24 and 48 mM of fructose with/without normal glucose in K/H solution for 20 min at the beginning of reperfusion...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29669261/chrebp-deficiency-leads-to-diarrhea-predominant-irritable-bowel-syndrome
#10
Ah-Reum Oh, Seonyong Sohn, Junghoon Lee, Jong-Min Park, Ki Taek Nam, Ki-Baik Hahm, Young-Bum Kim, Ho-Jae Lee, Ji-Young Cha
OBJECTIVE: Fructose malabsorption is a common digestive disorder in which absorption of fructose in the small intestine is impaired. An abnormality of the main intestinal fructose transporter proteins has been proposed as a cause for fructose malabsorption. However the underlying molecular mechanism for this remains unclear. In this study, we investigated whether carbohydrate response element-binding protein (ChREBP) plays a role in intestinal fructose absorption through the regulation of genes involved in fructose transport and metabolism and ion transport...
April 15, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29667441/long-term-consumption-of-western-diet-contributes-to-endothelial-dysfunction-and-aortic-remodeling-in-rats-implication-of-rho-kinase-signaling
#11
Rania A Elrashidy, Jing Zhang, Guiming Liu
Western diet (WD), rich in saturated fat and sugars, has become a risk factor for obesity and metabolic syndrome, however, its effect on endothelial function and vascular remodeling is not fully elucidated. Recent evidence suggests cross-talk between Rho kinase (ROCK) pathway and cardiovascular system. We aimed to investigate the effect of WD on aortic remodeling and the contribution of ROCK signaling. Eight week old male Sprague-Dawley rats were fed either standard chow diet (SD) or high fructose/ high-fat diet, typically as in WD...
April 18, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29666864/a-selective-glucose-sensor-the-cooperative-effect-of-monoboronic-acid-modified-poly-amidoamine-dendrimers
#12
Ching-Hua Tsai, Yi-Hsuan Tang, Hui-Ting Chen, Yi-Wen Yao, Tun-Cheng Chien, Chai-Lin Kao
Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.
April 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29666524/comparison-of-high-pressure-and-high-temperature-short-time-processing-on-quality-of-carambola-juice-during-cold-storage
#13
Hsiao-Wen Huang, Bang-Yuan Chen, Chung-Yi Wang
This study validated high hydrostatic pressure processing (HPP) for achieving greater than 5-log reductions of Escherichia coli O157:H7 in carambola juice and determined shelf life of processed juice stored at 4 °C. Carambola juice processed at 600 MPa for 150 s was identified capable of achieving greater than 5.15-log reductions of E. coli O157:H7, and the quality was compared with that of high temperature short time (HTST)-pasteurized juice at 110 °C for 8.6 s. Aerobic, psychrotrophic, E. coli /coliform, and yeasts and moulds in the juice were reduced by HPP or HTST to levels below the minimum detection limit (< 1...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666514/taste-characteristics-of-chinese-bayberry-juice-characterized-by-sensory-evaluation-chromatography-analysis-and-an-electronic-tongue
#14
Haiyan Yu, Yan Zhang, Jie Zhao, Huaixiang Tian
To evaluate the taste characteristics of Chinese bayberry juice, four types of bayberry juice sourced from different origins and varieties were analysed using sensory evaluation, chromatography, spectroscopy analysis and an electronic tongue (E-tongue). Nine organic acids and three sugars were assessed using high performance liquid chromatography. Total polyphenols were measured by spectrophotometry. The overall taste profile was collected using the E-tongue. The four types of bayberry juice differed in the sensory attributes of sour, sweet, bitter, and astringent...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29664676/a-mathematical-analysis-of-adaptations-to-the-metabolic-fate-of-fructose-in-essential-fructosuria-subjects
#15
R J Allen, Cynthia J Musante
Fructose is a major component of Western diets and is implicated in the pathogenesis of obesity and type 2 diabetes. In response to an oral challenge, the majority of fructose is cleared during "first-pass" liver metabolism, primarily via phosphorylation by ketohexokinase (KHK). A rare benign genetic deficiency in KHK, called essential fructosuria (EF), leads to altered fructose metabolism. The only reported symptom of EF is the appearance of fructose in the urine following either oral or intravenous fructose administration...
April 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29663934/fructose-enhanced-antimicrobial-activity-of-silver-nanoparticle-embedded-polymersome-nanocarriers
#16
Ilia Gelfat, Benjamin M Geilich, Thomas J Webster
In recent years, an increasing body of research has indicated that the antimicrobial activity of certain antibiotic drugs can be enhanced by the addition of specific metabolites. This study aimed to incorporate these findings into polymersomes (novel polymer-based nanoscale drug delivery vehicles) which can be loaded with various therapeutic molecules and nanoparticles. Polymersome technology has shown promising results in treating antibiotic-resistant infections by co-encapsulating the antibiotic methicillin with silver nanoparticles...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29662847/impact-of-various-factors-on-color-stability-of-fresh-blueberry-juice-during-storage
#17
Hyo-Nam Song, So-Ae Ji, Hye-Rim Park, Ho-Hyoen Kim, Christer Hogstrand
The attractive purple color of blueberries ( Vaccinium spp.) is unstable and susceptible to degradation during food processing and storage. The effects of various factors on the color stability of fresh blueberry juice were investigated. Total soluble solid content, pH, and total anthocyanin content were measured. Heating at 30°C and 60°C for 300 min did not influence the color stability, but heating at 100°C drastically decreased it by 33.0%. Sugars decreased color in a concentration-dependent manner. However, glucose and galactose had significantly protective effects on the color disruption than fructose, maltose, and sucrose...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29662843/insulinotropic-effect-of-s-allyl-cysteine-in-rat-pups
#18
Busisani W Lembede, Jeanette Joubert, Pilani Nkomozepi, Kennedy H Erlwanger, Eliton Chivandi
S -Allyl cysteine (SAC) is found in garlic and has been reported to exert antidiabetic and antiobesity properties in drug-induced adult experimental models of metabolic dysfunction, but its potential beneficial effects in high-fructose diet neonatal rat models have not been determined. This study investigated the potential prophylactic effects of SAC in high-fructose diet fed suckling rat pups modelling human neonates fed a high-fructose diet. Four-day-old male (n=32) and female (n=32) Wistar rat pups, were randomly assigned to and administered the following treatment regimens daily for 15 days: group I, distilled water; group II, 20% fructose solution (FS); group III, SAC; group IV, SAC+FS...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29661258/liver-metabolism-in-adult-male-mice-offspring-consequences-of-a-maternal-paternal-or-both-maternal-and-paternal-high-fructose-diet
#19
P V Carapeto, F Ornellas, C A Mandarim-de-Lacerda, M B Aguila
The study aimed to evaluate the consequences of the consumption of a high-fructose diet (HFR; fructose was responsible for 45% of the energy from carbohydrates) by the mother, the father, or both on C57BL/6 adult male offspring. Non-consanguineous parents received the diet (HFR or control, C) from 8 weeks before mating until weaning (n=10 fathers and n=10 mothers on each diet). After weaning, only the C diet was offered to offspring. The groups were formed by one male randomly taken from each litter. The offspring groups were identified according to the mother's diet (the first letter), then the father's diet (the second letter), that is, C/C, C/HFR, HFR/C, HFR/HFR (n=10 per group)...
April 17, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29660339/glut5-increases-fructose-utilization-and-promotes-tumor-progression-in-glioma
#20
Chunhai Su, Hui Li, Wenbo Gao
Fructose is now such an important component of human diets, and several studies have found that some cancer cells could utilize fructose to overcome low glucose micro-environment, but the study on the role of fructose in glioma is rare. To explore the role of fructose in glioma, we detected the proliferation and colony formation ability of glioma cells in fructose medium, and found that the abilities of proliferation and colony formation of glioma cells in fructose medium were similar with abilities in glucose medium, however, fructose just partly restored proliferation ability of normal glial cells...
April 13, 2018: Biochemical and Biophysical Research Communications
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