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https://www.readbyqxmd.com/read/27869092/erratum-to-baumann-bc-bosch-wr-bahl-a-et-al-development-and-validation-of%C3%A2-consensus-contouring-guidelines-for-adjuvant-radiation-therapy-for-bladder-cancer-after-radical-cystectomy-int-j-radiat-oncol-biol-phys-2016-96-78-86
#1
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December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843035/consensus-contouring-guidelines-for-postoperative-stereotactic-body-radiation-therapy-for-metastatic-solid-tumor-malignancies%C3%A2-to-the-spine
#2
Kristin J Redmond, Scott Robertson, Simon S Lo, Scott G Soltys, Samuel Ryu, Todd McNutt, Samuel T Chao, Yoshiya Yamada, Amol Ghia, Eric L Chang, Jason Sheehan, Arjun Sahgal
PURPOSE: To develop consensus contouring guidelines for postoperative stereotactic body radiation therapy (SBRT) for spinal metastases. METHODS AND MATERIALS: Ten spine SBRT specialists representing 10 international centers independently contoured the clinical target volume (CTV), planning target volume (PTV), spinal cord, and spinal cord planning organ at risk volume (PRV) for 10 representative clinical scenarios in postoperative spine SBRT for metastatic solid tumor malignancies...
September 17, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27837120/recommendations-for-high-risk-clinical-target-volume-definition-with-computed-tomography-for-three-dimensional-image-guided-brachytherapy-in-cervical-cancer-patients
#3
Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Li, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-Ei Noda, Tomoko Kazumoto, Yoko Harima
Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) for 3D image-guided brachytherapy (3D-IGBT) for cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology initiated guideline development for CT-based CTVHR (based on a comprehensive literature review as well as clinical experience) in July 2014. Extensive discussions occurred during four face-to-face meetings and frequent email communication until a consensus was reached...
November 10, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27821378/prevalence-of-humeral-head-osteochondrosis-in-the-greater-swiss-mountain-dog-and-the-border-collie-in-switzerland
#4
S Ohlerth, S Senn, U Geissbühler, P Kircher, M Flückiger
Osteochondrosis (OC) is common in large-breed dogs. According to the breeding guidelines of the Swiss kennel clubs, the shoulder joints are included in the radiographic screening for joint diseases in the Greater Swiss Mountain dog (GSMD) and the Border Collie (BC) since 1993 and 2003, respectively. The aim of this study was to estimate the overall prevalence of humeral head OC in these 2 breeds in Switzerland based on the data of the Swiss National Dysplasia Committees. All radiographs were re-evaluated to assess single radiographic changes...
November 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27816539/feasibility-study-of-toxicity-outcomes-using-gec-estro-contouring-guidelines-on-ct-based-instead-of-mri-based-planning-in-locally-advanced-cervical-cancer-patients
#5
Vicky Koh, Bok Ai Choo, Khai Mun Lee, Teng Hwee Tan, Jen Hui Jeffrey Low, Soon Yau Joseph Ng, Arunachalam Ilancheran, Liang Shen, Johann Tang
PURPOSE: To report late rectal and bladder toxicity outcomes of a CT-based image-guided brachytherapy (IGBT) technique for treatment of cervical cancer. METHODS AND MATERIALS: Between 2008 and 2014, 95 women with International Federation of Gynecology and Obstetrics stage IB to IVA cervical carcinoma treated with definitive concurrent cisplatin-based chemotherapy and external beam radiation therapy 50.4 Gy in 28 fractions followed by planned prescription dose of 7 Gy × 4 fractions of high-dose-rate IGBT was retrospectively reviewed...
November 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27802505/diagnosis-of-gout-a-systematic-review-in-support-of-an-american-college-of-physicians-clinical-practice-guideline
#6
Sydne J Newberry, John D FitzGerald, Aneesa Motala, Marika Booth, Margaret A Maglione, Dan Han, Abdul Tariq, Claire E O'Hanlon, Roberta Shanman, Whitney Dudley, Paul G Shekelle
Background: Alternative strategies exist for diagnosing gout that do not rely solely on the documentation of monosodium urate (MSU) crystals. Purpose: To summarize evidence regarding the accuracy of clinical tests and classification algorithms compared with that of a reference standard of MSU crystals in joint aspirate for diagnosing gout. Data Sources: Several electronic databases from inception to 29 February 2016. Study Selection: 21 prospective cohort, cross-sectional, and case-control studies including participants with joint inflammation and no previous definitive gout diagnosis who had MSU analysis of joint aspirate...
November 1, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27797223/hippocampal-sparing-whole-brain-radiotherapy-and-integrated-simultaneous-boost-vs-stereotactic-radiosurgery-boost-a-comparative-dosimetric-planning-study
#7
Soon Keat Cheah, Thomas Matthews, Bin Sing Teh
BACKGROUND: Whole brain radiotherapy (WBRT) and stereotactic radiosurgery were frequently used to palliate patients with brain metastases. It remains controversial which modality or combination of therapy is superior especially in the setting of limited number of brain metastases. The availability of newer medical therapy that improves survival highlighted the importance of reducing long term radiation toxicity associated with WBRT. In this study, we aim to demonstrate the hippocampal sparing technique with whole brain and integrated simultaneous boost Materials and Methods: Planning data from 10 patients with 1-5 brain metastases treated with SRS were identified...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27771259/implementation-of-national-body-contouring-surgery-guidelines-following-massive-weight-loss-a-national-cross-sectional-survey-of-commissioning-in-england
#8
Jonathan A Dunne, Justin C R Wormald, Reshma Ghedia, Mark Soldin
INTRODUCTION: National guidelines for commissioning of body contouring surgery (BCS) following massive weight loss (MWL) in England were published in 2014. Nearly three-quarters of patients who have MWL seek BCS; however, access is known to vary according to the region. The aim of national guidelines was to standardise access. The purpose of this study was to determine implementation of the national guidelines by clinical commissioning groups (CCGs) in England. MATERIALS AND METHODS: A cross-sectional, web-based survey was sent to all CCG chairs in England...
September 21, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27756417/pancreatic-cancer-adjuvant-radiotherapy-target-volume-design-based-on-the-postoperative-local-recurrence-spatial-location
#9
Wei Yu, Wei Hu, Yongjie Shui, Xiaoyang Zhu, Chao Li, Xiaoqiu Ren, Xueli Bai, Risheng Yu, Li Shen, Tingbo Liang, Lei Zheng, Qichun Wei
OBJECTIVES: To explore the areas at highest risk for postoperative pancreatic cancer local recurrence according to the spatial location of local failures, with the aim to provide a precise target volume for pancreatic cancer adjuvant radiotherapy. METHODS: Patients with pancreatic cancer who had undergone surgery for the primary tumor in pancreas at our institution from January 2010 to August 2015 were retrospectively analyzed. All local recurrences were plotted on the computed tomography (CT) image of a representative patient according to their relative coordinates to superior mesenteric artery (SMA) or celiac axis (CA)...
October 19, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27748126/simple-diagrammatic-method-to-delineate-male-urethra-in-prostate-cancer-radiotherapy-an-mri-based-approach
#10
Tejinder Kataria, Deepak Gupta, Shikha Goyal, Shyam S Bisht, Ravi Chaudhary, Kushal Narang, Susovan Banerjee, Trinanjan Basu, Ashu Abhishek, Sasikumar Sambasivam, Nisha T Vishnu
Stereotactic body radiotherapy (SBRT) is being increasingly utilized in the treatment of prostate cancer. With the advent of high-precision radiosurgery systems, it is possible to obtain dose distributions akin to high-dose rate brachytherapy with SBRT. However, urethral toxicity has a significant impact on the quality of life in patients with prostate cancer. Contouring the male urethra on a CT scan is difficult in the absence of an indwelling catheter. In this pictorial essay, we have used the MRI obtained for radiotherapy planning to aid in the delineation of the male urethra and have attempted to define guidelines for the same...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27743888/heart-dose-is-an-independent-dosimetric-predictor-of-overall-survival-in-locally-advanced-non-small-cell-lung-cancer
#11
Christina K Speirs, Todd A DeWees, Sana Rehman, Alerson Molotievschi, Maria A Velez, Daniel Mullen, Sandra Fergus, Marco Trovo, Jeffrey D Bradley, Cliff G Robinson
INTRODUCTION: In the randomized trial of standard- versus high-dose chemoradiotherapy for locally advanced (LA) NSCLC (Radiation Therapy Oncology Group 0617), overall survival (OS) was worse in the high-dose arm. Although heart dose was suggested as a contributing factor, actionable parameters have not been established. We present an analysis of clinical and dosimetric parameters affecting OS in this patient population, focusing on heart dose. METHODS: Clinical data were collected on 416 patients with LA NSCLC treated at a single institution, with a subset of 333 available treatment plans recontoured using Radiation Therapy Oncology Group 0617 normal tissue guidelines...
October 12, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27692518/treatment-planning-strategy-for-whole-brain-radiotherapy-with-hippocampal-sparing-and-simultaneous-integrated-boost-for-multiple-brain-metastases-using-intensity-modulated-arc-therapy
#12
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Xinglei Shen, Christopher Lominska, Habeeb Saleh, Rajeev Badkul, Hongyu Jiang, Melissa Mitchell, Fen Wang
PURPOSE: To retrospectively evaluate the accuracy, plan quality and efficiency of intensity-modulated arc therapy (IMAT) for hippocampal sparing whole-brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB) in patients with multiple brain metastases (m-BM). MATERIALS AND METHODS: A total of 5 patients with m-BM were retrospectively replanned for HS-WBRT with SIB using IMAT treatment planning. The hippocampus was contoured on diagnostic T1-weighted magnetic resonance imaging (MRI) which had been fused with the planning CT image set...
September 27, 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27680524/solid-implants-in-facial-plastic-surgery-potential-complications-and-how-to-prevent-them
#13
Krishna Patel, Kathleyn Brandstetter
Allogenic implants are an effective alternative to autologous grafts in the reconstruction of facial defects. These implants are used to reconstruct a variety of bony and soft-tissue defects, including the frontal and temporal regions; internal orbit; infraorbital rim; malar, paranasal, and nasal regions; mandible; and chin. In comparison to their autologous counterparts, alloplastic materials are more readily available, lack donor-site morbidity, decrease surgical time and cost, and still have relatively good postoperative tissue tolerance...
October 2016: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/27679540/uncertainties-in-target-volume-delineation-in-radiotherapy-are-they-relevant-and-what-can-we-do-about-them
#14
Barbara Segedin, Primoz Petric
BACKGROUND: Modern radiotherapy techniques enable delivery of high doses to the target volume without escalating dose to organs at risk, offering the possibility of better local control while preserving good quality of life. Uncertainties in target volume delineation have been demonstrated for most tumour sites, and various studies indicate that inconsistencies in target volume delineation may be larger than errors in all other steps of the treatment planning and delivery process. The aim of this paper is to summarize the degree of delineation uncertainties for different tumour sites reported in the literature and review the effect of strategies to minimize them...
September 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27633327/peer-review-of-radiotherapy-planning-quantifying-outcomes-and-a-proposal-for-prospective-data-collection
#15
J Mackenzie, G Graham, I A Olivotto
AIMS: The Canadian Partnership for Quality Radiotherapy quality assurance guidelines recommend that radiation oncologist peer review of curative radiotherapy plans takes place ideally before the first fraction of treatment is delivered. This study documented and evaluated the outcomes of weekly, disease site-specific, radiotherapy peer review, quality assurance rounds at the Tom Baker Cancer Centre in Calgary, Canada with a view to making recommendations about the optimal timing and documentation of peer review during the radiotherapy planning processes...
September 12, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27623066/a-comprehensive-strategy-in-the-development-of-a-cyclodextrin-modified-microemulsion-electrokinetic-chromatographic-method-for-the-assay-of-diclofenac-and-its-impurities-mixture-process-variable-experiments-and-quality-by-design
#16
S Orlandini, B Pasquini, C Caprini, M Del Bubba, L Squarcialupi, V Colotta, S Furlanetto
A comprehensive strategy involving the use of mixture-process variable (MPV) approach and Quality by Design principles has been applied in the development of a capillary electrophoresis method for the simultaneous determination of the anti-inflammatory drug diclofenac and its five related substances. The selected operative mode consisted in microemulsion electrokinetic chromatography with the addition of methyl-β-cyclodextrin. The critical process parameters included both the mixture components (MCs) of the microemulsion and the process variables (PVs)...
September 30, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27608919/degradation-kinetics-study-of-alogliptin-benzoate-in-alkaline-medium-by-validated-stability-indicating-hptlc-method
#17
Shailesh Shah, Bhavin Marolia, Pintu Prajapati, Kunjan Bharatkumar Bodiwala, Jeenal Thakor
A rapid, sensitive, and stability-indicating high-performance thin-layer chromatographic method was developed and validated to study degradation kinetics of Alogliptin benzoate (ALG) in an alkaline medium. ALG was degraded under acidic, alkaline, oxidative, and thermal stress conditions. The degraded samples were chromatographed on silica gel 60F254-TLC plates, developed using a quaternary-solvent system (chloroform-methanol-ethyl acetate-triethyl amine, 9+1+1+0.5, v/v/v/v), and scanned at 278 nm. The developed method was validated per International Conference on Harmonization guidelines using validation parameters such as specificity, linearity and range, precision, accuracy, LOD, and LOQ...
September 7, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27569406/environmental-propagation-of-noise-in-mines-and-nearby-villages-a-study-through-noise-mapping
#18
Veena D Manwar, Bibhuti B Mandal, Asim K Pal
BACKGROUND: Noise mapping being an established practice in Europe is hardly practiced for noise management in India although it is mandatory in Indian mines as per guidelines of the Directorate General of Mines Safety (DGMS). As a pilot study, noise mapping was conducted in an opencast mine with three different models; one based on the baseline operating conditions in two shifts (Situation A), and two other virtual situations where either production targets were enhanced by extending working hours to three shifts (Situation B) or only by increased mechanization and not changing the duration of work (Situation C)...
July 2016: Noise & Health
https://www.readbyqxmd.com/read/27527506/high-risk-ctv-delineation-for-cervix-brachytherapy-application-of-gec-estro-guidelines-in-australia-and-new-zealand
#19
Shalini K Vinod, Karen Lim, Lauren Bell, Jacqueline Veera, Lucy Ohanessian, Ewa Juresic, Nira Borok, Phillip Chan, Raphael Chee, Viet Do, Geetha Govindarajulu, Swetha Sridharan, Carol Johnson, Daniel Moses, Sylvia Van Dyk, Lois Holloway
INTRODUCTION: Image-based brachytherapy for cervical cancer using MRI has been implemented in Australia and New Zealand. The aims of this study were to measure variability in High-risk CTV (HR-CTV) delineation and evaluate dosimetric consequences of this. METHODS: Nine radiation oncologists, one radiation therapist and two radiologists contoured HR-CTV on 3T MRI datasets from ten consecutive patients undergoing cervical brachytherapy at a single institution. Contour comparisons were performed using the Dice Similarity Coefficient (DSC) and Mean Absolute Surface Distance (MASD)...
August 16, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27511849/development-and-validation-of-consensus-contouring-guidelines-for-adjuvant-radiation-therapy-for-bladder-cancer-after-radical-cystectomy
#20
Brian C Baumann, Walter R Bosch, Amit Bahl, Alison J Birtle, Rodney H Breau, Amarnath Challapalli, Albert J Chang, Ananya Choudhury, Sia Daneshmand, Ali El-Gayed, Adam Feldman, Steven E Finkelstein, Thomas J Guzzo, Serena Hilman, Ashesh Jani, S Bruce Malkowicz, Constantine A Mantz, Viraj Master, Anita V Mitra, Vedang Murthy, Sima P Porten, Pierre M Richaud, Paul Sargos, Jason A Efstathiou, Libni J Eapen, John P Christodouleas
PURPOSE: To develop multi-institutional consensus clinical target volumes (CTVs) and organs at risk (OARs) for male and female bladder cancer patients undergoing adjuvant radiation therapy (RT) in clinical trials. METHODS AND MATERIALS: We convened a multidisciplinary group of bladder cancer specialists from 15 centers and 5 countries. Six radiation oncologists and 7 urologists participated in the development of the initial contours. The group proposed initial language for the CTVs and OARs, and each radiation oncologist contoured them on computed tomography scans of a male and female cystectomy patient with input from ≥1 urologist...
September 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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