keyword
https://read.qxmd.com/read/38525767/an-aminoglycoside-sparing-regimen-with-double-beta-lactam-to-successfully-treat-granulicatella-adiacens-prosthetic-aortic-valve-endocarditis-time-to-change-paradigm
#21
Alberto Pagotto, Floriana Campanile, Paola Conti, Francesca Prataviera, Paola Della Siega, Sarah Flammini, Simone Giuliano, Luca Martini, Davide Pecori, Assunta Sartor, Maria Screm, Tosca Semenzin, Carlo Tascini
(1) Background: Granulicatella adiacens is a former nutritionally variant streptococci (NVS). NVS infective endocarditis (IE) is generally characterized by a higher rate of morbidity and mortality, partially due to difficulties in choosing the most adequate microbiological culture method and the most effective treatment strategy, and partially due to higher rates of complications, such as heart failure, peripheral septic embolism, and peri-valvular abscess, as well as a higher rate of valve replacement. Depending on the affected valve (native valve endocarditisNVE, or prosthetic valve endocarditisPVE), the American Heart Association (AHA) 2015 treatment guidelines (GLs) suggest penicillin G, ampicillin, or ceftriaxone plus gentamicin (2 weeks for NVE and up to 6 weeks for PVE), while vancomycin alone may be a reasonable alternative in patients who are intolerant of β-lactam therapy...
March 14, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38525608/targeted-gene-deletion-or-antagonism-of-the-prostaglandin-e2-ep3-receptor-protects-against-cardiac-injury-postmyocardial-infarction
#22
JOURNAL ARTICLE
Timothy D Bryson, Shaheen Y Bhat, Carlin Moore, David Taube, Jiang Xu, Edward Peterson, Pamela Harding
BACKGROUND: Prostaglandin E2 acts through 4 G-protein-coupled receptors (EP1-EP4). We previously reported that activation of the EP3 receptor reduces cardiac contractility, and its expression increases after a myocardial infarction (MI), mediating the reduction in cardiac function. In contrast, cardiac overexpression of the EP4 receptor in MI substantially improves cardiac function. Moreover, we recently reported that mice overexpressing EP3 have heart failure under basal conditions and worsened cardiac function after MI...
March 25, 2024: Circulation. Heart Failure
https://read.qxmd.com/read/38525190/case-report-of-belt-electrode-skeletal-muscle-electrical-stimulation-for-acute-heart-failure-with-severe-obesity-a-novel-therapeutic-option-for-acute-phase-rehabilitation
#23
Yuto Mochizuki, Takahiro Jimba, Syota Yasukawa, Aritomo Katsura, Akira Fukuda, Jiro Ando
BACKGROUND: Belt electrode skeletal muscle electrical stimulation (B-SES) is an emerging therapy anticipated to yield more favorable outcomes than conventional neuromuscular electrical stimulation (NMES), owing to its larger stimulation area. However, information on its efficacy and safety in patients with heart failure remains limited. CASE PRESENTATION: A 43-year-old man with a body mass index of 41 kg/m2 was admitted to our hospital for acute heart failure due to dilated cardiomyopathy...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38524995/percutaneous-balloon-dilation-of-the-pulmonary-valve-in-a-79-year-old-with-congenital-pulmonary-valve-stenosis
#24
Matthew C Schwartz, Jorge Alegria, Joseph Paolillo, Markus Scherer
• Congenital valvar PS is a rare cause of heart failure in the geriatric population. • Transcatheter PV dilation is an effective treatment of congenital PS in older adults. • Cardiac CT can be very useful in the evaluation of suspected valvar PS in adults.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524992/a-tale-of-three-chambers-cor-triatriatum-sinistrum
#25
Maliha Butt, Husban Halim, Ataul Qureshi, Ryan Koene, Su Aung, Tara Karamlou, Ashish Saini
• Cor triatriatum is an important cause of HF and atrial arrhythmias in young adults. • Misdiagnosis can cause inappropriate interventions and delay in surgical treatment. • Integrated imaging is useful in describing anatomy and associated abnormalities. • Collaboration between hospitals and cardiac specialties helps prevent poor outcomes.
March 2024: CASE: Cardiovascular Imaging Case Reports
https://read.qxmd.com/read/38524633/vericiguat-in-patients-with-heart-failure-across-the-spectrum-of-left-ventricular-ejection-fraction-a-patient-level-pooled-meta-analysis-of-vitality-hfpef-and-victoria
#26
REVIEW
Chao Chen, Jin Lv, Changzhao Liu
Vericiguat, the newest soluble guanylate cyclase (sGC) drug, is potentially beneficial in treating heart failure (HF). However, most studies have only confirmed the significant impact of sGC in patients with reduced left ventricular ejection fraction (LVEF). Therefore, the main objective of this meta-analysis was to comparatively analyze the effects of Vericiguat in the entire LVEF range based on previous studies. According to PubMed, Web of Science, Cochrane, and Embase databases, randomized controlled studies in the full LVEF stage range were screened, and two extensive clinical studies on Vericiguat, namely VICTORIA (LVEF<45%) and VITALITY-HFpEF (LVEF≥45%) were identified for analysis and systematic evaluation...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38524515/significant-risk-factors-for-intensive-care-unit-acquired-weakness-a-processing-strategy-based-on-repeated-machine-learning
#27
JOURNAL ARTICLE
Ling Wang, Deng-Yan Long
BACKGROUND: Intensive care unit-acquired weakness (ICU-AW) is a common complication that significantly impacts the patient's recovery process, even leading to adverse outcomes. Currently, there is a lack of effective preventive measures. AIM: To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment. METHODS: Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38524037/altered-mental-status-in-the-setting-of-thrombotic-thrombocytopenic-purpura-ttp-and-spontaneous-coronary-artery-dissection-scad-a-case-report-and-literature-review
#28
Esmirna Perez, Nehemias Guevara, Jordan Smith, Ricardo Velasquez
Altered mental status (AMS) is a common condition encountered in daily practice. Finding the cause is essential for treatment, but sometimes this may be challenging. Spontaneous coronary artery dissection (SCAD) is frequently underdiagnosed and is a potentially fatal cause of acute coronary syndrome. Clinical presentation depends on the extent of SCAD, ranging from unstable angina to sudden death. AMS has not been reported with this condition, but it may be possible in hypoperfusion states. Thrombotic thrombocytopenic purpura (TTP) is part of the microangiopathic hemolytic anemia (MAHA) spectrum, presenting with AMS as the cardinal symptom...
February 2024: Curēus
https://read.qxmd.com/read/38523985/clinical-features-and-treatment-of-patients-infected-with-sars-cov-2-omicron-variant-while-hospitalized-due-to-stroke-a-single-center-study-in-japan
#29
JOURNAL ARTICLE
Kazuki Miyazaki, Hiroshi Kanno, Sachiko Yamada, Yuuki Sagehashi, Shutaro Matsumoto, Satoru Takahashi, Yongson Kim, Keiko Namiki, Satoshi Fujii
BACKGROUND AND OBJECTIVE: In December 2019, COVID-19 spread rapidly across the globe. Throughout the pandemic, SARS-CoV-2 repeatedly mutated, transitioning from the alpha variant to the omicron variant. The severity and mortality of COVID-19 have been linked to age, sex, and the presence of underlying diseases (respiratory, cerebrovascular, cardiovascular, metabolic, and immune diseases, as well as cancer). The clinical features of patients infected with COVID-19 following a stroke, however, are fully unknown...
February 2024: Curēus
https://read.qxmd.com/read/38523465/prediction-of-cardiovascular-and-renal-risk-among-patients-with-apparent-treatment-resistant-hypertension-in-the-united-states-using-machine-learning-methods
#30
JOURNAL ARTICLE
George Bakris, Pei Paul Lin, Chang Xu, Cindy Chen, Veronica Ashton, Mukul Singhal
Apparent treatment-resistant hypertension (aTRH), defined as blood pressure (BP) that remains uncontrolled despite unconfirmed concurrent treatment with three antihypertensives, is associated with an increased risk of developing cardiovascular and renal complications compared with controlled hypertension. We aimed to identify the characteristics of aTRH patients with an elevated risk of major adverse cardiovascular events plus (MACE+; defined as stroke, myocardial infarction, or heart failure hospitalization) and end stage renal disease (ESRD)...
March 24, 2024: Journal of Clinical Hypertension
https://read.qxmd.com/read/38522861/successful-treatment-of-generalized-pustular-psoriasis-with-guselkumab
#31
JOURNAL ARTICLE
Martina Part
The purpose of the article: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory disease. Patients with GPP may develop life-threatening complications, including sepsis, acute renal failure, neutrophilic cholangitis, high-output congestive heart failure, acute respiratory distress syndrome and death. The therapy of GPP is very limited and the course of the disease is unpredictable. Materials and methods: We report a 60-year-old woman presenting with widespread and confluent erythematous-desquamative plaques with numerous small pustules covering almost 70% of the body surface area...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38522637/functional-mitral-regurgitation-and-heart-failure-with-preserved-ejection-fraction-clinical-implications-and-management
#32
REVIEW
M Riccardi, M Cikes, M Adamo, M Pagnesi, C M Lombardi, S D Solomon, M Metra, R M Inciardi
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and associated with worse cardiovascular outcomes. The pathophysiology of HFpEF mostly relies on the development of elevated left ventricle filling pressure, diastolic dysfunction, atrial dilatation and impairment. This dynamic process may eventually lead to the development of functional mitral regurgitation, characterized by mitral annular dilatation and consequent leaflet remodelling, in the context of preserved left ventricular ejection fraction...
March 22, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38522367/multiple-matrices-metabolomics-combined-with-serum-pharmacochemistry-for-discovering-the-potential-targets-and-active-constituents-of-qifu-decoction-against-heart-failure
#33
JOURNAL ARTICLE
Xingxing Zhang, Wenting Liao, Xin Ding, Ya Zhang, Cuiping Long, Qian Zhou, Yuwei Wang, Hong Wu, Guangguo Tan
Qifu decoction (QFD) is an ancient traditional Chinese medicine (TCM) prescription for the treatment of heart failure. However, the mechanisms and active constituents of QFD are poorly understood. In this study, multi-matrices metabolomics (serum, urine, and myocardial mitochondria) based on ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOFMS), were employed for exploring the mechanisms of QFD against heart failure in rat model. Twenty-one, seventeen, and fifteen endogenous metabolite biomarkers associated with heart failure were identified from serum, urine, and myocardial mitochondria datasets, respectively...
March 16, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38522242/diagnostic-accuracy-of-prehospital-lung-ultrasound-for-acute-decompensated-heart-failure-a-systematic-review-and-meta-analysis
#34
REVIEW
Frances M Russell, Nicholas E Harrison, Oliver Hobson, Nicholas Montelauro, Cecelia J Vetter, Daniel Brenner, Sarah Kennedy, Benton R Hunter
BACKGROUND: Lung ultrasound (LUS) reduces time to diagnosis and treatment of acute decompensated heart failure (ADHF) in emergency department (ED) patients with undifferentiated dyspnea. We conducted a systematic review to evaluate the diagnostic accuracy and clinical impact of LUS for ADHF in the prehospital setting. METHODS: We performed a keyword search of multiple databases from inception through June 1, 2023. Included studies were those enrolling prehospital patients with undifferentiated dyspnea or suspected ADHF, and specifically diagnostic studies comparing prehospital LUS to a gold standard and intervention studies with a non-US comparator group...
March 18, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38521855/nadph-oxidase-2-mediates-cardiac-sympathetic-denervation-and-myocyte-autophagy-resulting-in-cardiac-atrophy-and-dysfunction-in-doxorubicin-induced-cardiomyopathy
#35
JOURNAL ARTICLE
Yuan Ma, Hui-Ping Zhao, Li-Guo Yang, Lu Li, Ai-Lin Wang, Xiao-Juan Zhang, Ke Wang, Bin Yang, Zong-Feng Zhu, Pei-Jun Zhang, Jia-Pu Wang, Rui-Fang Chi, Bao Li, Fu-Zhong Qin, Zhi-Peng Wang
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated. In this study, we tested whether NADPH oxidase 2 (Nox2) mediates cardiac sympathetic nerve terminal abnormalities and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced heart failure. Nox2 knockout (KO) and wild-type (WT) mice were randomly assigned to receive a single injection of doxorubicin (15 mg/kg, i...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38521547/one-year-postprocedural-quality-of-life-following-mitral-valve-surgery-data-from-the-netherlands-heart-registration
#36
JOURNAL ARTICLE
Samuel Heuts, Jules R Olsthoorn, Saskia Houterman, Maaike M Roefs, Jos G Maessen, Peyman Sardari Nia
OBJECTIVES: The aim of surgical treatment of mitral valve disease is to reverse heart failure and to restore life expectancy and quality of life (QoL). In mitral valve surgery, QoL has not been studied extensively, especially regarding the surgical approach. The current study aimed to evaluate QoL after mitral valve surgery through full sternotomy and a minimally invasive approach (MIMVS). METHODS: All patients undergoing mitral valve surgery between 2013-2018 through sternotomy or a MIMVS approach (right anterolateral mini-thoracotomy, sternal-sparing), with or without concomitant tricuspid valve surgery, surgical ablation, or atrial septal defect closure were eligible for inclusion in this multicentre nationwide registry in the Netherlands...
March 23, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38521487/sulfide-catabolism-in-hibernation-and-neuroprotection
#37
JOURNAL ARTICLE
Fumito Ichinose, Allyson Hindle
The mammalian brain is exquisitely vulnerable to lack of oxygen. However, the mechanism underlying the brain's sensitivity to hypoxia is incompletely understood. In this narrative review, we present a case for sulfide catabolism as a key defense mechanism of the brain against acute oxygen shortage. We will examine literature on the role of sulfide in hypoxia/ischemia, deep hibernation, and leigh syndrome patients, and present our recent data that support the neuroprotective effects of sulfide catabolism and persulfide production...
March 21, 2024: Nitric Oxide: Biology and Chemistry
https://read.qxmd.com/read/38520626/patterns-of-comorbidities-and-prescribing-and-dispensing-of-non-steroidal-anti-inflammatory-drugs-nsaids-among-patients-with-osteoarthritis-in-the-usa-real-world-study
#38
JOURNAL ARTICLE
Joshua Ide, Azza Shoaibi, Kerstin Wagner, Rachel Weinstein, Kathleen E Boyle, Andrew Myers
BACKGROUND: Osteoarthritis (OA) is a major cause of chronic pain. Non-steroidal anti-inflammatory drugs (NSAIDs) are analgesics commonly used for musculoskeletal pain; however, NSAIDs can increase the risk of certain adverse events, such as gastrointestinal bleeding, edema, heart failure, and hypertension. OBJECTIVE: The objective of this study was to characterize existing comorbidities among patients with OA. For patients with OA with and without a coexisting medical condition of interest (CMCOI), we estimated the prevalence of prescribing and dispensing NSAIDs pre-OA and post-OA diagnosis...
March 23, 2024: Drugs & Aging
https://read.qxmd.com/read/38520434/mortality-benefit-among-primary-prevention-implantable-cardioverter-defibrillator-recipients-on-contemporary-heart%C3%A2-failure-treatment
#39
JOURNAL ARTICLE
Aamir Ahmed, Angelo Auricchio, Suneet Mittal, Robert A Pickett, Bruce L Wilkoff, Luke D Jacobsen, Anne K Marti, Reece W Holbrook, Dana M Soderlund, Anne B Curtis
BACKGROUND: Past clinical trials have shown the benefit of implantable cardioverter-defibrillators (ICDs) for reducing sudden cardiac death in at-risk patients. However, heart failure management and ICD technology have changed since these trials were first published. An updated assessment of ICD mortality benefit is needed. OBJECTIVES: The purpose of this study was to compare mortality rates between patients with a primary prevention (PP) indication for an ICD who did or did not receive an ICD using a contemporary, real-world data set...
February 24, 2024: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/38520316/ch-vad-left-ventricular-assist-implantation-combined-with-the-bentall-procedure-and-coronary-artery-bypass-grafting
#40
Shuanglei Zhao, Chongyang Liu, Jun Wang, Hong Wang, Tiange Luo, Xiaoyan Hao, Xian Yang, Mingxiu Wen, Jie Han, Hongjia Zhang, Ming Gong
Left ventricular assist device (LVAD) implantation is an effective alternative treatment to heart transplantation, especially for end-stage heart failure patients who are ineligible for or unable to await a heart transplant. This report describes a complex and innovative surgery where LVAD implantation was performed alongside multiple concomitant cardiac and aortic procedures. A 62-year-old male patient with complicated comorbidities developed acute myocardial infarction and subsequent refractory advanced heart failure...
March 23, 2024: ESC Heart Failure
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