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Spirometry and lung function

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https://www.readbyqxmd.com/read/29782663/prospective-study-confirms-that-bronchiolitis-in-early-infancy-increases-the-risk-of-reduced-lung-function-at-10-13-years-of-age
#1
Riikka Riikonen, Eero Lauhkonen, Sari Törmänen, Katri Backman, Petri Koponen, Merja Helminen, Kirsi Nuolivirta, Matti Korppi
AIM: This study evaluated children hospitalised for bronchiolitis at less than six months of age to see if they had reduced lung function in early adolescence. METHODS: We have prospectively followed 166 children hospitalised for infant bronchiolitis in 2001-2004 at Tampere University Hospital, Finland. At 10-13 years of age, flow-volume spirometry was measured in 89 cases and 108 controls without infant bronchiolitis from the local population register. Parameters of flow-volume spirometry before and after bronchodilation were analysed...
May 21, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29769147/association-of-pulmonary-cardiovascular-and-hematologic-metrics-with-carbon-nanotube-and-nanofiber-exposure-among-u-s-workers-a-cross-sectional-study
#2
Mary K Schubauer-Berigan, Matthew M Dahm, Aaron Erdely, John D Beard, M Eileen Birch, Douglas E Evans, Joseph E Fernback, Robert R Mercer, Stephen J Bertke, Tracy Eye, Marie A de Perio
BACKGROUND: Commercial use of carbon nanotubes and nanofibers (CNT/F) in composites and electronics is increasing; however, little is known about health effects among workers. We conducted a cross-sectional study among 108 workers at 12 U.S. CNT/F facilities. We evaluated chest symptoms or respiratory allergies since starting work with CNT/F, lung function, resting blood pressure (BP), resting heart rate (RHR), and complete blood count (CBC) components. METHODS: We conducted multi-day, full-shift sampling to measure background-corrected elemental carbon (EC) and CNT/F structure count concentrations, and collected induced sputum to measure CNT/F in the respiratory tract...
May 16, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29768509/aging-related-trajectories-of-lung-function-in-the-general-population-the-doetinchem-cohort-study
#3
Sandra H van Oostrom, Peter M Engelfriet, W M Monique Verschuren, Maarten Schipper, Inge M Wouters, Marike Boezen, Henriëtte A Smit, Huib A M Kerstjens, H Susan J Picavet
The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards...
2018: PloS One
https://www.readbyqxmd.com/read/29755755/lung-volumes-identify-an-at-risk-group-in-persons-with-prolonged-secondhand-tobacco-smoke-exposure-but-without-overt-airflow-obstruction
#4
Mehrdad Arjomandi, Siyang Zeng, Jeroen Geerts, Rachel K Stiner, Bruce Bos, Ian van Koeverden, Jason Keene, Brett Elicker, Paul D Blanc, Warren M Gold
Introduction: Exposure to secondhand smoke (SHS) is associated with occult obstructive lung disease as evident by abnormal airflow indices representing small airway disease despite having preserved spirometry (normal forced expiratory volume in 1 s-to-forced vital capacity ratio, FEV1 /FVC). The significance of lung volumes that reflect air trapping in the presence of preserved spirometry is unclear. Methods: To investigate whether lung volumes representing air trapping could determine susceptibility to respiratory morbidity in people with SHS exposure but without spirometric chronic obstructive pulmonary disease, we examined a cohort of 256 subjects with prolonged occupational SHS exposure and preserved spirometry...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29752708/coexistence-of-chronic-bronchitis-in-chronic-obstructive-lung-disease
#5
Filip Mejza, Paweł Nastałek, Agnieszka Mastalerz-Migas, Zbigniew Doniec, Wojciech Skucha
The incidence of chronic obstructive pulmonary disease (COPD) is on the rise worldwide. Chronic bronchitis is a frequent accompaniment of COPD, which increases the burden of COPD in affected individuals. The aim of this study was to characterize the phenotype of chronic bronchitis in COPD patients. The study was based on the survey data retrospectively retrieved from the Action Health-Lung Cancer Prophylaxis and Health Care Improvement screening program that concerned all the inhabitants, aged over 40, of the Proszowice administrative region situated in the Lesser Poland Voivodeship in southern Poland...
May 12, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29751547/the-relationship-between-diabetes-mellitus-and-respiratory-function-in-patients-eligible-for-coronary-artery-bypass-grafting
#6
Aleksandra Szylińska, Mariusz Listewnik, Żaneta Ciosek, Magdalena Ptak, Anna Mikołajczyk, Wioletta Pawlukowska, Iwona Rotter
Introduction: Spirometry performed prior to surgery provides information on the types of lung disorders in patients. The purpose of this study was to look for a relationship between the prevalence of diabetes and spirometry parameters. Material and Methods: The study was conducted in patients with coronary artery disease who were eligible for an isolated coronary artery bypass graft in 2013. The study group included 367 patients (287 men and 80 women) aged 68.7 ± 8.4 years. They were divided into those with diagnosed diabetes (group I, n = 138, 37...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29748304/tobacco-smoke-exposure-in-early-life-and-adolescence-in-relation-to-lung-function
#7
Jesse D Thacher, Erica S Schultz, Jenny Hallberg, Ulrika Hellberg, Inger Kull, Per Thunqvist, Göran Pershagen, Per M Gustafsson, Erik Melén, Anna Bergström
Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure, and adolescent smoking on lung function at age 16 years.The BAMSE birth cohort collected information on participant's tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16. Participants performed spirometry and impulse oscillometry (IOS) at age 16 (n=2295)...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29742906/relationship-of-spirometric-body-plethysmographic-and-diffusing-capacity-parameters-to-emphysema-scores-derived-from-ct-scans
#8
Kathrin Kahnert, Bertram Jobst, Frank Biertz, Jürgen Biederer, Henrik Watz, Rudolf M Huber, Jürgen Behr, Philippe A Grenier, Peter Alter, Claus F Vogelmeier, Hans-Ulrich Kauczor, Rudolf A Jörres
Phenotyping of chronic obstructive pulmonary disease (COPD) with computed tomography (CT) is used to distinguish between emphysema- and airway-dominated type. The phenotype is reflected in correlations with lung function measures. Among these, the relative value of body plethysmography has not been quantified. We addressed this question using CT scans retrospectively collected from clinical routine in a large COPD cohort. Three hundred and thirty five patients with baseline data of the German COPD cohort COPD and Systemic Consequences-Comorbidities Network were included...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29734571/spirometry-and-oxidative-stress-after-rebreather-diving-in-warm-water
#9
Gerardo Bosco, Alex Rizzato, Silvia Quartesan, Enrico Camporesi, Simona Mrakic-Sposta, Sarah Moretti, Costantino Balestra, Alessandro Rubini
Introduction: Hyperbaric oxygen (HBO₂) therapy and use of enriched air can result in oxidative injury affecting the brain, lungs and eyes. HBO₂ exposure during diving can lead to a decrease in respiratory parameters. However, the possible effects of acute exposure to oxygen-enriched diving on subsequent spirometric performance and oxidative state in humans have not been recently described recently. We aim to investigate possible effects of acute (i) hyperbaric and (ii) hyperbaric hyperoxic exposure using scuba or closed-circuit rebreather (CCR) on subsequent spirometry and to assess the role of oxidative state after hyperoxic diving...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29732947/pulmonary-hypofunction-due-to-calcium-carbonate-nanomaterial-exposure-in-occupational-workers-a-cross-sectional-study
#10
Guoliang Li, Lihong Liang, Jingchao Yang, Lihai Zeng, Zhiwei Xie, Yizhou Zhong, Xiaolin Ruan, Ming Dong, Zhanhong Yang, Guanchao Lai, Weixin Huang, Aichu Yang, Jiabing Chen, Banghua Wu, Huaming Xu, Dezhi Meng, Shijie Hu, Lihua Xia, Xingfen Yang, Laiyu Li, Sahoko Ichihara, Gaku Ichihara, Hanlin Huang, Zhenlie Huang
Calcium carbonate nanomaterials (nano-CaCO3 ) are widely used in both manufacturing and consumer products, but their potential health hazards remain unclear. The objective of this study was to survey workplace exposure levels and health effects of workers exposed to nano-CaCO3 . Personal and area sampling, as well as real-time and dust monitoring, were performed to characterize mass exposure, particle size distribution, and particle number exposure. A total of 56 workers (28 exposed workers and 28 unexposed controls) were studied in a cross-sectional study...
May 6, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29725972/congruence-between-pulmonary-function-and-computed-tomography-imaging-assessment-of-cystic-fibrosis-severity
#11
Anna Rybacka, Joanna Goździk-Spychalska, Adam Rybacki, Tomasz Piorunek, Halina Batura-Gabryel, Katarzyna Karmelita-Katulska
In cystic fibrosis, pulmonary function tests (PFTs) and computed tomography are used to assess lung function and structure, respectively. Although both techniques of assessment are congruent there are lingering doubts about which PFTs variables show the best congruence with computed tomography scoring. In this study we addressed the issue by reinvestigating the association between PFTs variables and the score of changes seen in computed tomography scans in patients with cystic fibrosis with and without pulmonary exacerbation...
May 4, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29716705/evaluation-for-airway-obstruction-in-adult-patients-with-stable-ischemic-heart-disease
#12
M Mahendra, Sunil Kumar S, Nagaraj Desai, Jayaraj Bs, Mahesh Pa
BACKGROUND: Ischemic heart disease (IHD) and chronic airway disease (COPD and Asthma) are major epidemics accounting for significant mortality and morbidity. The combination presents many diagnostic challenges. Clinical symptoms and signs frequently overlap. There is a need for airway evaluation in these patients to plan appropriate management. METHODS: Consecutive stable IHD patients attending the cardiology OPD in a tertiary care centre were interviewed for collecting basic demographic information, brief medical, occupational, personal history and risk factors for coronary artery disease and airway disease, modified medical research centre (MMRC) grade for dyspnea, quality of life-St...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29713159/the-impact-of-exposure-to-biomass-smoke-versus-cigarette-smoke-on-inflammatory-markers-and-pulmonary-function-parameters-in-patients-with-chronic-respiratory-failure
#13
Birsen Ocakli, Eylem Acarturk, Emine Aksoy, Sinem Gungor, Fulya Ciyiltepe, Selahattin Oztas, Ipek Ozmen, Meltem Coban Agca, Cuneyt Salturk, Nalan Adiguzel, Zuhal Karakurt
Purpose: The aim of this study was to evaluate the impact of exposure to biomass smoke vs cigarette smoke on serum inflammatory markers and pulmonary function parameters in patients with chronic respiratory failure (CRF). Patients and methods: A total of 106 patients with CRF divided into age and gender-matched groups of cigarette-smoke exposure (n=55, mean [SD] age: 71.0 [12.0] years, 92.7% were females) and biomass smoke exposure (n=51, mean [SD] age: 73.0 [11...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29703608/influence-of-snps-in-genes-that-modulate-lung-disease-severity-in-a-group-of-mexican-patients-with-cystic-fibrosis
#14
Emiy Yokoyama, Margarita Chávez-Saldaña, Lorena Orozco, Francisco Cuevas, José Luis Lezana, Rosa María Vigueras-Villaseñor, Julio Cesar Rojas-Castañeda, Daniel Adrian Landero
BACKGROUND: The variation in cystic fibrosis (CF) lung disease not always is explained by the CFTR genotype, so it has become apparent that modifier genes must play a considerable role in the phenotypic heterogeneity of CF, so we investigated the association of allelic variants in modifier genes that modulate the severity of lung function in a group of Mexican patients diagnosed with CF. METHODS: We included 140 CF patients classified according to lung phenotype and analyzed 17 single nucleotide polymorphisms (SNPs) by TaqMan® allelic discrimination...
April 24, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29702682/restrictive-lung-disorder-is-common-in-patients-with-kidney-failure-and-associates-with-protein-energy-wasting-inflammation-and-cardiovascular-disease
#15
Hideyuki Mukai, Pei Ming, Bengt Lindholm, Olof Heimbürger, Peter Barany, Björn Anderstam, Peter Stenvinkel, Abdul Rashid Qureshi
BACKGROUND: Cardiovascular disease (CVD), protein-energy wasting (PEW), and inflammation are common interrelated features of chronic kidney disease (CKD). Less is known about lung dysfunction in CKD and its possible role in this context. We evaluated lung function and its association with estimated glomerular filtration rate (GFR), CVD, PEW, and inflammation in individuals with normal to severely reduced GFR. METHODS: In 404 individuals with GFR category G1 (n = 31; GFR >90mL/min/1...
2018: PloS One
https://www.readbyqxmd.com/read/29697074/air-pollution-and-environmental-risk-factors-for-altered-lung-function-among-adult-women-of-an-urban-slum-area-of-delhi-a-prevalence-study
#16
Shweta Arora, S K Rasania, D Bachani, Asha Gandhi, S K Chhabra
Background: Household and ambient air pollution are jointly responsible for about 7 million premature deaths annually. Women living in slums, with unhealthy environment, both indoors and outdoors, particularly those living close to industrial and/or vehicular pollution zones due to multiple sources of air pollution, are at the higher risk of having impaired lung function tests. Objective: The aim of this study was to estimate the prevalence of abnormal lung functions and to identify the environmental risk factors associated with them among adult women of 18-59 years...
May 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29692608/increased-matrix-metalloproteinase-9-to-tissue-inhibitor-of-metalloproteinase-1-ratio-in-smokers-with-airway-hyperresponsiveness-and-accelerated-lung-function-decline
#17
Chun-Yu Lo, Hung-Yu Huang, Jung-Ru He, Tzu-Ting Huang, Chih-Chen Heh, Te-Fang Sheng, Kian Fan Chung, Han-Pin Kuo, Chun-Hua Wang
Background: Airway hyperresponsiveness (AHR) is associated with airway inflammation and a rapid decline in lung function and is a predictor of future risk of COPD among smokers. Alveolar macrophages (AMs) from patients with COPD release a greater amount of matrix metalloproteinase (MMP)-9. We hypothesized that the imbalance between MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) is related to AHR in smokers. Patients and methods: Healthy smokers with AHR (AHR + S) or smokers without AHR (AHR - S; divided according to a methacholine challenge test) and nonsmokers without AHR (AHR - NS) were enrolled...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29690880/abnormal-pulmonary-function-tests-predict-the-development-of-radiation-induced-pneumonitis-in-advanced-non-small-cell-lung-cancer
#18
L Torre-Bouscoulet, W R Muñoz-Montaño, D Martínez-Briseño, F J Lozano-Ruiz, R Fernández-Plata, J A Beck-Magaña, C García-Sancho, A Guzmán-Barragán, E Vergara, M Blake-Cerda, L Gochicoa-Rangel, F Maldonado, M Arroyo-Hernández, O Arrieta
BACKGROUND: Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predict RP in non-small cell lung cancer (NSCLC) patients. METHODS: A prospective multi-institutional study was conducted with locally advanced and oligometastatic NSCLC patients...
April 24, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29686742/time-to-exhale-additional-value-of-expiratory-chest-ct-in-chronic-obstructive-pulmonary-disease
#19
Joshua Gawlitza, Frederik Trinkmann, Hans Scheffel, Andreas Fischer, John W Nance, Claudia Henzler, Nils Vogler, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Stefan O Schoenberg, Thomas Henzler
Objectives: Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients. We hypothesized that expiratory CT may be superior to demonstrate pathophysiological changes. The aim of this prospective study was to systematically compare lung function tests with quantified CT parameters in inspiration and expiration...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29683991/systemic-inflammation-immune-activation-and-impaired-lung-function-among-people-living-with-hiv-in-rural-uganda
#20
Crystal M North, Daniel Muyanja, Bernard Kakuhikire, Alexander C Tsai, Russell P Tracy, Peter W Hunt, Douglas S Kwon, David C Christiani, Samson Okello, Mark J Siedner
BACKGROUND: Although both chronic lung disease and HIV are inflammatory diseases common in sub-Saharan Africa, the relationship between systemic inflammation and lung function among people living with HIV (PLWH) in sub-Saharan Africa is not well described. METHODS: We measured lung function (using spirometry) and serum high sensitivity C-reactive protein, IL-6, sCD14 and sCD163 in 125 PLWH on stable antiretroviral therapy and 109 age and sex-similar HIV-uninfected controls in rural Uganda...
April 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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