Bing Zhao, Mengjiao Li, Wenwu Sun, Jian Li, Leshan Liu, Yihui Wang, Silei Sun, Lili Xu, Xing Qi, Mengqi Xie, Yuhua Zhou, Tongtian Ni, Yi Yao, Peili Chen, Meiling Yu, Weisong Jiang, Ning Ning, Huiqiu Sheng, Erzhen Chen, Ruilan Wang, Chaoyang Tong, Yu Cao, Mingwei Sun, Enqiang Mao
BACKGROUND: Sepsis is an inflammatory syndrome with life-threatening organ dysfunction and high mortality. In the recent 10 years, high-dose intravenous injection of vitamin C, the first-line antioxidant of humans, has received highlighted attention in the field of critical care. The study aims to examine the efficacy and safety of high-dose intravenous injection of vitamin C in the treatment of sepsis. METHODS AND DESIGN: Here, we are conducting a prospective, multi-centered, double-blinded, randomized, and placebo-controlled superiority study named High-Dose Vitamin C on Sepsis (HDVCOS)...
2022: Frontiers in Medicine